Pub Date : 2023-07-30DOI: 10.53346/wjbpr.2023.5.1.0056
David A Dawson
This literature review examines theoretical frameworks related to applying the principles of biomolecular psychology and psychoneuroimmunology to devise a nutraceutical protocol utilizing phytochemicals for the treatment of posttraumatic stress disorder with a particular focus on modulating the endocannabinoid system through the utilization of molecules inherent in chemovars of Cannabis sativa. It provides a psychosocial overview of posttraumatic stress disorder and the historically controversial and noncontroversial nature of the biologically derived molecules that have demonstrated efficacy in addressing the effects major stressors have on the biomolecular mechanisms that cause mood disorders that manifest themselves as symptoms of PTSD.
{"title":"Theoretical frameworks toward a nutraceutical approach to treating PTSD","authors":"David A Dawson","doi":"10.53346/wjbpr.2023.5.1.0056","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.1.0056","url":null,"abstract":"This literature review examines theoretical frameworks related to applying the principles of biomolecular psychology and psychoneuroimmunology to devise a nutraceutical protocol utilizing phytochemicals for the treatment of posttraumatic stress disorder with a particular focus on modulating the endocannabinoid system through the utilization of molecules inherent in chemovars of Cannabis sativa. It provides a psychosocial overview of posttraumatic stress disorder and the historically controversial and noncontroversial nature of the biologically derived molecules that have demonstrated efficacy in addressing the effects major stressors have on the biomolecular mechanisms that cause mood disorders that manifest themselves as symptoms of PTSD.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132779048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.53346/wjbpr.2023.4.2.0054
Carlos Henrique Marchiori
Bees of the Megachilidae family are solitary, they build their nests with pieces of leaves and vegetable remains or use holes in trunks. Bees of this family are found with high frequency, mainly in open areas. Frequent visitors to Asteraceae and Fabaceae flowers, the genus Megachile is the most diverse of the group. Megachilidae nests, built with pieces of plant leaves, are found inside the camera. Megachilidae bees cut the leaves of a plant to build their nests. The objective of this bibliographical production is to know the biology, ecology and taxonomic characteristics of the Megachilidae family. In terms of the type of research source, we worked with scientific articles published in national and international journals and other documents. This modality of production, in addition to being commonly the most valued in the set of bibliographic production, is the most easily accessed. Access to articles was through virtual libraries such as SciELO, ResearchGate, Hall, USP, UNB, CAPES, Qeios and LILACS.
{"title":"Bees of the Megachilidae family (Insecta: Hymenoptera)","authors":"Carlos Henrique Marchiori","doi":"10.53346/wjbpr.2023.4.2.0054","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.4.2.0054","url":null,"abstract":"Bees of the Megachilidae family are solitary, they build their nests with pieces of leaves and vegetable remains or use holes in trunks. Bees of this family are found with high frequency, mainly in open areas. Frequent visitors to Asteraceae and Fabaceae flowers, the genus Megachile is the most diverse of the group. Megachilidae nests, built with pieces of plant leaves, are found inside the camera. Megachilidae bees cut the leaves of a plant to build their nests. The objective of this bibliographical production is to know the biology, ecology and taxonomic characteristics of the Megachilidae family. In terms of the type of research source, we worked with scientific articles published in national and international journals and other documents. This modality of production, in addition to being commonly the most valued in the set of bibliographic production, is the most easily accessed. Access to articles was through virtual libraries such as SciELO, ResearchGate, Hall, USP, UNB, CAPES, Qeios and LILACS.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114530524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.53346/wjbpr.2023.4.2.0051
Desdiani Desdiani
One of the life-threatening multi-organ emergency conditions is Stevens-Johnson Syndrome (SJS). Although this is a rare disease and manifests as drug reactions, this condition can cause death.We present a case of a 63-year-old male with Diclofenac sodium and Allopurinol induced Stevens_Johnson Syndrome in pulmonary tuberculosis patients receiving intensive phase first-line antituberculosis drugs.The patient was undergoing outpatient TB treatment at the end of the first month. The patient comes to the emergency department of the hospital because of shortness of breath, fever, blistered skin, nasal and oral mucosa, cracks and wounds, visible pus, red eyes accompanied by erythematous rash all over the body after previously taking diclofenac sodium and allopurinol given by the doctor because felt joint pain all over body and uric acid increased. On physical examination of the lungs, crackles and wheezing were heard in both lung fields. The chest radiograph shows infiltrates in both lung fields. Laboratory results showed leukocytosis and the results of other blood laboratory tests were still within normal limits. Patient diagnosed Stevens-Johnson Syndrome based on clinical, laboratory, and radiology examination results. The patient was given treatments using nasal canule oxygen of 5 litres/minute, intravenous fluid dehydration D5% : NaCl 0.9%, ceftriaxone injection, gentamicin injection, dexamethasone injection, cetirizine ranitidine injection, compresses with 0.9% NaCl liquid, 2.5% hydrocortisone ointment. The patient was treated in the Intensive Care Unit for 8 days. The patient had no history of previous drug allergies. In this case, the likelihood of Diclofenac sodium and Allopurinol induced Stevens_Johnson Syndrome in pulmonary tuberculosis patients receiving intensive phase first-line antituberculosis drugs, needs to be a concerned, as well as the importance of evaluation and strict follow-up to prevent Stevens Johnson Syndrome disease.
{"title":"Diclofenac sodium and Allopurinol induced Stevens Johnson Syndrome in pulmonary tuberculosis patients receiving intensive phase first-line antituberculosis drugs","authors":"Desdiani Desdiani","doi":"10.53346/wjbpr.2023.4.2.0051","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.4.2.0051","url":null,"abstract":"One of the life-threatening multi-organ emergency conditions is Stevens-Johnson Syndrome (SJS). Although this is a rare disease and manifests as drug reactions, this condition can cause death.We present a case of a 63-year-old male with Diclofenac sodium and Allopurinol induced Stevens_Johnson Syndrome in pulmonary tuberculosis patients receiving intensive phase first-line antituberculosis drugs.The patient was undergoing outpatient TB treatment at the end of the first month. The patient comes to the emergency department of the hospital because of shortness of breath, fever, blistered skin, nasal and oral mucosa, cracks and wounds, visible pus, red eyes accompanied by erythematous rash all over the body after previously taking diclofenac sodium and allopurinol given by the doctor because felt joint pain all over body and uric acid increased. On physical examination of the lungs, crackles and wheezing were heard in both lung fields. The chest radiograph shows infiltrates in both lung fields. Laboratory results showed leukocytosis and the results of other blood laboratory tests were still within normal limits. Patient diagnosed Stevens-Johnson Syndrome based on clinical, laboratory, and radiology examination results. The patient was given treatments using nasal canule oxygen of 5 litres/minute, intravenous fluid dehydration D5% : NaCl 0.9%, ceftriaxone injection, gentamicin injection, dexamethasone injection, cetirizine ranitidine injection, compresses with 0.9% NaCl liquid, 2.5% hydrocortisone ointment. The patient was treated in the Intensive Care Unit for 8 days. The patient had no history of previous drug allergies. In this case, the likelihood of Diclofenac sodium and Allopurinol induced Stevens_Johnson Syndrome in pulmonary tuberculosis patients receiving intensive phase first-line antituberculosis drugs, needs to be a concerned, as well as the importance of evaluation and strict follow-up to prevent Stevens Johnson Syndrome disease.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132533649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.53346/wjbpr.2023.4.2.0044
Isabelly Da Mata, Castro Lima, Daniely de, Almeida Andrade, Maria Eduarda Oliveira, Luciano Ambrósio Ferreira
Introduction: Synovial Chondromatosis (SC) is a metaplastic rheumatologic condition that manifests itself in the Temporomandibular Joints (TMJs). This causes common symptoms related to Temporomandibular Disorders (TMD). Differential diagnosis is obtained through clinical and imaging evaluation. Objective: To clarify, through a systematic review, the manifestations that characterize, differentiate and relate SC in the TMJ from the point of view of clinical and imaging diagnosis. Material and methods: The PubMed database and the keywords were used: Synovial Chondromatosis, Clinical Diagnosis, Imaging Tests, TMD Patient, Healthy Patients, Signs and Symptoms. Inclusion criteria were: five years, English language, title covering the keywords and clinical and original research in humans, literature reviews and case reports. As exclusion criteria: cases that did not deal with SC in the ATM, articles that do not match the objective of the work. The characteristiSC, differences and relationships between TMD and SC were the main variables analyzed. Results: Initially, 335 articles were found, after application of filters, inclusion criteria and evaluation of abstracts, nine were selected. Five relevant publications were added. The signs and symptoms common to the alterations: localized joint pain, edema, limitation of mouth opening and joint noises. Magnetic resonance images, computed tomography and TMJ radiographs were fundamental for the differential diagnosis and indicated the presence of intraarticular fibrocartilaginous bodies in the SC. Conclusion: It is necessary to interpret the imaging tests in order to establish the differential diagnosis between TMD and SC.
{"title":"Clinical and imaginological characterization of synovial chondromatosis in the temporomandibular joint: A systematic review","authors":"Isabelly Da Mata, Castro Lima, Daniely de, Almeida Andrade, Maria Eduarda Oliveira, Luciano Ambrósio Ferreira","doi":"10.53346/wjbpr.2023.4.2.0044","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.4.2.0044","url":null,"abstract":"Introduction: Synovial Chondromatosis (SC) is a metaplastic rheumatologic condition that manifests itself in the Temporomandibular Joints (TMJs). This causes common symptoms related to Temporomandibular Disorders (TMD). Differential diagnosis is obtained through clinical and imaging evaluation. Objective: To clarify, through a systematic review, the manifestations that characterize, differentiate and relate SC in the TMJ from the point of view of clinical and imaging diagnosis. Material and methods: The PubMed database and the keywords were used: Synovial Chondromatosis, Clinical Diagnosis, Imaging Tests, TMD Patient, Healthy Patients, Signs and Symptoms. Inclusion criteria were: five years, English language, title covering the keywords and clinical and original research in humans, literature reviews and case reports. As exclusion criteria: cases that did not deal with SC in the ATM, articles that do not match the objective of the work. The characteristiSC, differences and relationships between TMD and SC were the main variables analyzed. Results: Initially, 335 articles were found, after application of filters, inclusion criteria and evaluation of abstracts, nine were selected. Five relevant publications were added. The signs and symptoms common to the alterations: localized joint pain, edema, limitation of mouth opening and joint noises. Magnetic resonance images, computed tomography and TMJ radiographs were fundamental for the differential diagnosis and indicated the presence of intraarticular fibrocartilaginous bodies in the SC. Conclusion: It is necessary to interpret the imaging tests in order to establish the differential diagnosis between TMD and SC.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123915409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.53346/wjbpr.2023.4.1.0048
Hadeel T AL-Hadithi, Zahira M AL-Khani
Efficacy of two types of contact lens disinfecting (CLD) solutions, most frequently purchased from Jordanian pharmacies by contact lens wearers, was investigated for reducing growth rate of methicillin resistant and methicillin sensitive Staphylococcus aureus, Serratia marcesence, S. liquefacience and Acinetobacter spp., previously isolated from In-use disinfecting solutions in CL cases. Each species was cultured in a clean and dirty conditions (to mimic real situation) of two fresh CLD solutions separately: A and B whose active agents are: Polyhexamethylene biguanide hydrochloride and Polyaminopropyl biguanide respectively. Log reduction of these bacteria have exceeded ISO 14729 acceptable criteria (3 log) and reached up to 5 log reduction. Dirty conditions have marked effect in reducing efficacy of CLD solution (A) to kill bacterial species under test. Biofilms produced by S. marcescens and S. liquefaciens were reduced by more than 50% after 24 hrs. using either CLD solutions, though it was less than that reduced after 4 hrs. Biofilm of methicillin resistant Staphylococcus aureus (MRSA) was the most affected by either CLD solutions after 4 hours. This study concluded that CL wearers should pay great consideration to cleaning and disinfection practices to decrease bacterial growth, reduce chances of biofilm formation.
{"title":"Efficacy of two contact lens disinfecting solutions in reducing growth rate of bacteria and eradication of biofilms","authors":"Hadeel T AL-Hadithi, Zahira M AL-Khani","doi":"10.53346/wjbpr.2023.4.1.0048","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.4.1.0048","url":null,"abstract":"Efficacy of two types of contact lens disinfecting (CLD) solutions, most frequently purchased from Jordanian pharmacies by contact lens wearers, was investigated for reducing growth rate of methicillin resistant and methicillin sensitive Staphylococcus aureus, Serratia marcesence, S. liquefacience and Acinetobacter spp., previously isolated from In-use disinfecting solutions in CL cases. Each species was cultured in a clean and dirty conditions (to mimic real situation) of two fresh CLD solutions separately: A and B whose active agents are: Polyhexamethylene biguanide hydrochloride and Polyaminopropyl biguanide respectively. Log reduction of these bacteria have exceeded ISO 14729 acceptable criteria (3 log) and reached up to 5 log reduction. Dirty conditions have marked effect in reducing efficacy of CLD solution (A) to kill bacterial species under test. Biofilms produced by S. marcescens and S. liquefaciens were reduced by more than 50% after 24 hrs. using either CLD solutions, though it was less than that reduced after 4 hrs. Biofilm of methicillin resistant Staphylococcus aureus (MRSA) was the most affected by either CLD solutions after 4 hours. This study concluded that CL wearers should pay great consideration to cleaning and disinfection practices to decrease bacterial growth, reduce chances of biofilm formation.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123559429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study was to investigate the activity of the hydroalcoholic extract ofBombacopsis glabra leaves in rat. The mucoprotector effect of B. glabra leaves hydroalcoholic extract was studied by evaluating its ability to protect the mucosa from aggression of repeated oral administration of indomethacin at a dose of 30 mg/kg while pylorus ligature was used to study its anti-secretory effect. The results show that hydroalcoholic extract of the leaves of B. glabra, at doses 300 and 600mg/kg, decrease the surface area of lesions induced by indomethacin from 6.2 observed in the control group animals to 2.51 and 1.19 0.073 mm² respectively, in the treated animals (p 0.05). The extract decreases gastric acidity by increasing the pH of the gastric content from 1.7 0.03 of the control animals to 2.27 3.59 0.11 of the animals that received the extract at dose 300 and 600mg/kg respectively (p<0.05). These results show that the hydroalcoholic extract of B. glabra leaves possesses an anti-secretory effect and acts as a mucoprotector, and therefore has an antiulcer activity. The alkaloids, flavonoids, tannins, or polysaccharides in the extract could be responsible for this activity.
{"title":"Antiulcer activity of hydroalcoholic extract of Bombacopsis glabra (Pasq.) A. Robyns. Leaves (Bombacaceae) in rat","authors":"Solofoniaina Gabriel ANDRIAMALALA, TianarilalainaTantely ANDRIAMAMPIANINA, Fanantenanirainy RANDIMBIVOLOLONA, Nathaniel QUANSAH, Patricia RANDRIANAVONY","doi":"10.53346/wjbpr.2023.4.1.0045","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.4.1.0045","url":null,"abstract":"The purpose of this study was to investigate the activity of the hydroalcoholic extract ofBombacopsis glabra leaves in rat. The mucoprotector effect of B. glabra leaves hydroalcoholic extract was studied by evaluating its ability to protect the mucosa from aggression of repeated oral administration of indomethacin at a dose of 30 mg/kg while pylorus ligature was used to study its anti-secretory effect. The results show that hydroalcoholic extract of the leaves of B. glabra, at doses 300 and 600mg/kg, decrease the surface area of lesions induced by indomethacin from 6.2 observed in the control group animals to 2.51 and 1.19 0.073 mm² respectively, in the treated animals (p 0.05). The extract decreases gastric acidity by increasing the pH of the gastric content from 1.7 0.03 of the control animals to 2.27 3.59 0.11 of the animals that received the extract at dose 300 and 600mg/kg respectively (p<0.05). These results show that the hydroalcoholic extract of B. glabra leaves possesses an anti-secretory effect and acts as a mucoprotector, and therefore has an antiulcer activity. The alkaloids, flavonoids, tannins, or polysaccharides in the extract could be responsible for this activity.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124788184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-30DOI: 10.53346/wjbpr.2023.4.1.0047
Maria Dalamagka
Word "pain" derives its origin from the Indo-European root aleg meaning to suffer. Word "pain" is later and comes from the Latin word "poena" meaning punishment. Since ancient times there has been disagreement regarding the perception of pain and its evaluation. Unlike sight, hearing and smell, pain does not seem to be a primary sensation, but rather an emotional experience. Most pain researchers view pain as a complex perception, induced by noxious stimuli. Although pain is the most frequent symptom in medicine and despite the enormous advances that have been made in the field of analgesia and anesthesia, the pathophysiological mechanisms involved in its generation and maintenance are not fully understood. Definition of pain was given in 1979 by the classification committee of the international association for the study of pain (IASP) "as an unpleasant aesthetic and emotional experience, associated with actual or potential tissue damage or described in terms of such damage". In other words, although physiology and anatomy determine a precise point of reference for the detection and transmission of messages interpreted as painful, what differentiates the experience of pain is the fact that there is always an emotional gradient to the experience of pain. The purpose of the review is to investigate the analgesic system. Pain signals can be blocked at their initial point of entry into the spinal cord. Analgesia system may also inhibit pain transmission elsewhere in the nociceptive pathway. Because most drugs that alter neuronal excitability act on synaptic receptors, it has been suggested that the "morphine receptors" of the analgesia system must actually be receptors for some morphine-like neurotransmitter that is secreted normally from the brain.
{"title":"Mechanism of Pain","authors":"Maria Dalamagka","doi":"10.53346/wjbpr.2023.4.1.0047","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.4.1.0047","url":null,"abstract":"Word \"pain\" derives its origin from the Indo-European root aleg meaning to suffer. Word \"pain\" is later and comes from the Latin word \"poena\" meaning punishment. Since ancient times there has been disagreement regarding the perception of pain and its evaluation. Unlike sight, hearing and smell, pain does not seem to be a primary sensation, but rather an emotional experience. Most pain researchers view pain as a complex perception, induced by noxious stimuli. Although pain is the most frequent symptom in medicine and despite the enormous advances that have been made in the field of analgesia and anesthesia, the pathophysiological mechanisms involved in its generation and maintenance are not fully understood. Definition of pain was given in 1979 by the classification committee of the international association for the study of pain (IASP) \"as an unpleasant aesthetic and emotional experience, associated with actual or potential tissue damage or described in terms of such damage\". In other words, although physiology and anatomy determine a precise point of reference for the detection and transmission of messages interpreted as painful, what differentiates the experience of pain is the fact that there is always an emotional gradient to the experience of pain. The purpose of the review is to investigate the analgesic system. Pain signals can be blocked at their initial point of entry into the spinal cord. Analgesia system may also inhibit pain transmission elsewhere in the nociceptive pathway. Because most drugs that alter neuronal excitability act on synaptic receptors, it has been suggested that the \"morphine receptors\" of the analgesia system must actually be receptors for some morphine-like neurotransmitter that is secreted normally from the brain.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131894243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-30DOI: 10.53346/wjbpr.2023.4.1.0046
FH RAKOTONJAFINIARIVO, S NIRY MANANTSOA, HJ HERINIAINA, MK RANAIVOSOA, A RASAMINDRAKOTROKA
Objective: To describe the epidemiological and biological profile and the cardiac troponin level of patients infected with SARS-CoV-2 who underwent troponinemia testing. Methods: Retrospective descriptive and analytical study during a period of 5 months in which were included all patients with COVID-19, hospitalized at the Joseph Ravoahangy Andrianavalona University Hospital (CHU-JRA) in Antananarivo Madagascar and having performed a high sensitive cardiac troponin (hs-cTn) determination at the Biochemistry Laboratory of the same Hospital. . Study parameters were demographics, reasons for admission, medical history, oxygen saturation and patient outcome and paraclinical parameters were troponin level, chest CT image. Results: Among the 103 cases collected, 46.6% had an elevated hs-cTn level and mostly patients aged 71 to 80 years. Of the 43 patients who died, 60.5% were men. Most had cardiovascular risk factors, oxygen desaturation and critical parenchymal damage on chest CT. There was a significant difference between hs-cTn positivity and female gender and that therapeutic management was corrected after the troponin result. Among the deceased patients, 28 (65,11%) have high troponin levels. Conclusion: Troponin testing is important in patients with COVID-19 to detect the risk of mortality due to cardiovascular complications.
{"title":"Troponin level in SARS-CoV-2 patients in a biochemistry lab in Antananarivo Madagascar","authors":"FH RAKOTONJAFINIARIVO, S NIRY MANANTSOA, HJ HERINIAINA, MK RANAIVOSOA, A RASAMINDRAKOTROKA","doi":"10.53346/wjbpr.2023.4.1.0046","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.4.1.0046","url":null,"abstract":"Objective: To describe the epidemiological and biological profile and the cardiac troponin level of patients infected with SARS-CoV-2 who underwent troponinemia testing. Methods: Retrospective descriptive and analytical study during a period of 5 months in which were included all patients with COVID-19, hospitalized at the Joseph Ravoahangy Andrianavalona University Hospital (CHU-JRA) in Antananarivo Madagascar and having performed a high sensitive cardiac troponin (hs-cTn) determination at the Biochemistry Laboratory of the same Hospital. . Study parameters were demographics, reasons for admission, medical history, oxygen saturation and patient outcome and paraclinical parameters were troponin level, chest CT image. Results: Among the 103 cases collected, 46.6% had an elevated hs-cTn level and mostly patients aged 71 to 80 years. Of the 43 patients who died, 60.5% were men. Most had cardiovascular risk factors, oxygen desaturation and critical parenchymal damage on chest CT. There was a significant difference between hs-cTn positivity and female gender and that therapeutic management was corrected after the troponin result. Among the deceased patients, 28 (65,11%) have high troponin levels. Conclusion: Troponin testing is important in patients with COVID-19 to detect the risk of mortality due to cardiovascular complications.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128363726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.53346/wjbpr.2022.3.2.0040
Gogichadze TG, Gedenidze SA, Gogichadze GK
Normal somatic cells sensitive to carcinogenic effects and capable of proliferation form firstly a binuclear cells (dikaryons) and then hybrid cells (mononucleated synkaryons) by means of fusion with another cells of the same organism, in particular with differentiated and non-differentiated cells of corresponding tissue or with cells capable to migrate. In all probability, during the perforation of the plasma membrane, i.e., after the formation of pores, induced by different carcinogenic (and noncarcinogenic) agents and factors, the total negative charge of plasma membrane changes (decreases) and the cells develop the ability to come closer to each other, which will probably be the prerequisite to a fusion process. On the other hand, it is not excluded that perforation can assist the fusion of only neighboring cells. Initially, a set of chromosomes in a precancerous cell retains, even for a short time, the condition of tetraploidy. Because of cell fusion generates tetraploidy, it potentially might cause chromosomal instability. The article emphasizes a possibility of using the fusion process in different aspects of carcinogenesis (therapy, prevention, etc.).
{"title":"Perspectives of using of somatic cells fusion process in some aspects of car¬cino¬ge-nesis","authors":"Gogichadze TG, Gedenidze SA, Gogichadze GK","doi":"10.53346/wjbpr.2022.3.2.0040","DOIUrl":"https://doi.org/10.53346/wjbpr.2022.3.2.0040","url":null,"abstract":"Normal somatic cells sensitive to carcinogenic effects and capable of proliferation form firstly a binuclear cells (dikaryons) and then hybrid cells (mononucleated synkaryons) by means of fusion with another cells of the same organism, in particular with differentiated and non-differentiated cells of corresponding tissue or with cells capable to migrate. In all probability, during the perforation of the plasma membrane, i.e., after the formation of pores, induced by different carcinogenic (and noncarcinogenic) agents and factors, the total negative charge of plasma membrane changes (decreases) and the cells develop the ability to come closer to each other, which will probably be the prerequisite to a fusion process. On the other hand, it is not excluded that perforation can assist the fusion of only neighboring cells. Initially, a set of chromosomes in a precancerous cell retains, even for a short time, the condition of tetraploidy. Because of cell fusion generates tetraploidy, it potentially might cause chromosomal instability. The article emphasizes a possibility of using the fusion process in different aspects of carcinogenesis (therapy, prevention, etc.).","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121667933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Diarrheal infections associated to multidrug resistant bacteria are a public health problem, particularly in the tropics. Objective: The aim of this study was to describe a Multidrug resistant strain of Escherichia coli (E. coli) isolated from diarrheal stools. Patients and methods: A sample of diarrheal stools from a 30 years old housekeeper patient was analysed at China-Guinea Friendship Hospital of Kipé/Conakry. Parasitological examination by optical microscopy, followed by bacteriological analysis were done. Cultures were carried out on different agar media. Bacterial identification, antibiograms and minimum inhibitory concentrations (MIC) were performed using the Vitek 2 System. Results: The isolated E. coli strain was sensitive only to 4 of 29 antibiotics tested including imipenem, ertapenem, amikacin and nitrofurantoin. Intermediate sensitivity was detected towards minocycline. In contrast, this strain was resistant to piperacillin, cefuroxime, cefuroxime axetil, cefixime, ceftriaxone, cefepime, aztreonam, meropenem, levofloxacin, ofloxacin, tetracycline, tigecycline, chloramphenicol, trimethoprim, ampicillin, amoxicillin/clavulanic acid, ticarcillin, piperacillin/tazobactam, cephalothin, cefotaxime, ceftazidime, gentamicin, tobramycin, nalidixic acid, ciprofloxacin, ofloxacin and trimethoprim/sulfamethoxazole with high MICs. Conclusion: The treatment of this multidrug-resistant Escherichia coli diarrheal infection requires appropriate antibiotic therapy, based on the results of an accurate antibiogram to be performed with rapid means for better patient care.
{"title":"A multidrug- resistance pattern of an Escherichia coli strain isolated from diarrheal stools at the China-Guinea Friendship Hospital of Kipé in Conakry","authors":"Abdoulaye Makanéra, Mariam Condé, Taliby Dos Camara, Mamadou Alpha Diallo, Mariama Condé, Daouda Camara, Alpha Oumar Barry, Tiguidanké Diakité, Oumar Souaré","doi":"10.53346/wjbpr.2022.3.2.0043","DOIUrl":"https://doi.org/10.53346/wjbpr.2022.3.2.0043","url":null,"abstract":"Introduction: Diarrheal infections associated to multidrug resistant bacteria are a public health problem, particularly in the tropics. Objective: The aim of this study was to describe a Multidrug resistant strain of Escherichia coli (E. coli) isolated from diarrheal stools. Patients and methods: A sample of diarrheal stools from a 30 years old housekeeper patient was analysed at China-Guinea Friendship Hospital of Kipé/Conakry. Parasitological examination by optical microscopy, followed by bacteriological analysis were done. Cultures were carried out on different agar media. Bacterial identification, antibiograms and minimum inhibitory concentrations (MIC) were performed using the Vitek 2 System. Results: The isolated E. coli strain was sensitive only to 4 of 29 antibiotics tested including imipenem, ertapenem, amikacin and nitrofurantoin. Intermediate sensitivity was detected towards minocycline. In contrast, this strain was resistant to piperacillin, cefuroxime, cefuroxime axetil, cefixime, ceftriaxone, cefepime, aztreonam, meropenem, levofloxacin, ofloxacin, tetracycline, tigecycline, chloramphenicol, trimethoprim, ampicillin, amoxicillin/clavulanic acid, ticarcillin, piperacillin/tazobactam, cephalothin, cefotaxime, ceftazidime, gentamicin, tobramycin, nalidixic acid, ciprofloxacin, ofloxacin and trimethoprim/sulfamethoxazole with high MICs. Conclusion: The treatment of this multidrug-resistant Escherichia coli diarrheal infection requires appropriate antibiotic therapy, based on the results of an accurate antibiogram to be performed with rapid means for better patient care.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125527466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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