In this problem, an unsteady magnetohydrodynamic heat and mass transfer study of hybrid nanofluid flow through porous media over a stretched sheet is performed. Additionally, the impacts of thermal radiation and chemical reactions are examined. Alumina (Al2O3) and titanium oxide (TiO2) nanoparticles are mixed, and water is used as the base fluid to create hybrid nanoparticles. The strategy of nonlinear partial differential equations that govern the deconstruction of liquid flow has been diverted into an approach of ordinary differential equations via similitude changeovers and non-dimensional variables. Then, they were solved numerically utilizing the Rung-Kutta fourth-order strategy and miscellaneous firing techniques. The consequence of the derived physical characteristics on the disbandment of momentum, temperature, and concentration of micro particles has also been researched, employing illustrated representations to assign physical meanings to each parameter. This research was conducted to determine the effects of the physical parameters. It should be noted that heat and mass transfer on magnetohydrodynamic flows through porous media, considering the effect of chemical reactions, appears in many natural and artificial transport processes in several branches of science and engineering applications. This phenomenon plays a vital role in the chemical, power, and cooling industries for drying, chemical vapor deposition on surfaces, cooling of nuclear reactors, and petroleum industries. The effects of thermal radiation, mass, and heat transfer are used in many situations in biomedical engineering and aerospace engineering.