Roya Abbasi Natajomrani, D. Qujeq, R. Hajihosseini, V. Hosseini
Background: Lipids are usually crucial to develop tumors, and dyslipidemia is correlated with the high chance of colon and colorectal cancer (CRC). Steroid hormones such as estrogen and progesterone can decrease the risk of colorectal cancer development. Objectives: The present study aimed to compare the serum levels of lipid profile and steroid hormones in patients with CRC and healthy controls. Methods: The present study included 40 consecutive adult patients with CRC in the Mazandaran Cancer Center, Sari, Iran, between 2017 and 2020.The diagnosis of CRC was evaluated based on colonoscopy with biopsy and CT scan. Also, the diagnosis of CRC was based on NCCN clinical practice guidelines in oncology. Blood samples were taken before treatment during routine testing. A 5 mL of peripheral blood was collected from each patient. All patients signed the written consent for the study. Also, a total of 40 healthy subjects were selected as healthy controls from the same area during a routine physical examination, which was also confirmed by screening colonoscopy and pathology. Serum TCh and TG levels were quantitatively determined by the colorimetric method. LDL-C and HDL-C were determined by the turbidimetric immunoassay. Steroid hormones were quantitatively determined by the Enzyme-linked immunosorbent assay (ELISA) according to the reagent manufacturer’s instruction. To analyze data, the SPSS software package (version 21) was applied. Results: Among all the indicators studied, the (mean ± SD) of testosterone, FSH and LH levels was higher (1.85 ± 1.63 ng/ml, 15.35 ± 0.13mIU/l, 12.42 ± 0.12.16mIU/ml) in patients with CRC than (mean ± SD) healthy controls (0.40 ± 0.21ng/ml, 6.27 ± 0.50mIU/ml, 2.89 ± 0.20mIU/ml, P < 0.05), respectively. Also, the results in subgroups showed that the mean testosterone (0.91 ± 1.2ng/l), FSH (19.11 ± 16mIU/ml), LH (14.49 ± 14mIU/ml) levels in the woman patients with CRC was higher than healthy female controls and had more statistical significance (p = 0.02, 0.00, 0.00), respectively. The area under the AUC cure (Figure 1) of the testosterone, FSH, and LH indicates positive test (0.670, 0.726 and 0.775). Conclusions: Changes in the levels of steroid hormones and lipids could correlate with the elevated chance of CRC. Therefore, assessment of multiple markers might overcome and provide better judgment in patients with CRC.
背景:脂质通常对肿瘤的发生至关重要，而血脂异常与结直肠癌(CRC)的高发病几率相关。类固醇激素如雌激素和黄体酮可以降低患结直肠癌的风险。目的:本研究旨在比较结直肠癌患者和健康对照者的血脂和类固醇激素水平。方法:本研究纳入了2017年至2020年在伊朗萨里Mazandaran癌症中心连续收治的40例成年结直肠癌患者。结直肠癌的诊断基于结肠镜活检和CT扫描。此外，CRC的诊断是基于肿瘤学NCCN临床实践指南。在治疗前进行常规检测时采集血样。每位患者采集外周血5ml。所有患者都签署了这项研究的书面同意书。同时，从同一地区选取40名健康受试者作为常规体检的健康对照，并通过结肠镜筛查和病理检查确认。用比色法定量测定血清TCh和TG水平。用免疫比浊法测定LDL-C和HDL-C。根据试剂制造商的说明，用酶联免疫吸附试验(ELISA)定量测定类固醇激素。采用SPSS软件包(version 21)进行数据分析。结果:在所研究的各项指标中，结直肠癌患者睾酮、FSH和LH水平(平均±SD)(1.85±1.63 ng/ml、15.35±0.13mIU/l、12.42±0.12.16mIU/ml)高于健康对照组(平均±SD)(0.40±0.21ng/ml、6.27±0.50mIU/ml、2.89±0.20mIU/ml, P < 0.05)。亚组结果显示，女性结直肠癌患者睾酮(0.91±1.2ng/l)、卵泡刺激素(19.11±16mIU/ml)、LH(14.49±14mIU/ml)水平均高于健康女性对照组，差异有统计学意义(p = 0.02, 0.00, 0.00)。睾酮、FSH、LH的AUC曲线下面积(图1)为阳性(0.670、0.726、0.775)。结论:类固醇激素和脂质水平的变化可能与结直肠癌发病率升高有关。因此，多种标志物的评估可能会克服并为结直肠癌患者提供更好的判断。
{"title":"Serum Lipid Profile and Steroid Hormone Levels in Patients with Colorectal Cancer","authors":"Roya Abbasi Natajomrani, D. Qujeq, R. Hajihosseini, V. Hosseini","doi":"10.5812/hmj.102085","DOIUrl":"https://doi.org/10.5812/hmj.102085","url":null,"abstract":"Background: Lipids are usually crucial to develop tumors, and dyslipidemia is correlated with the high chance of colon and colorectal cancer (CRC). Steroid hormones such as estrogen and progesterone can decrease the risk of colorectal cancer development. Objectives: The present study aimed to compare the serum levels of lipid profile and steroid hormones in patients with CRC and healthy controls. Methods: The present study included 40 consecutive adult patients with CRC in the Mazandaran Cancer Center, Sari, Iran, between 2017 and 2020.The diagnosis of CRC was evaluated based on colonoscopy with biopsy and CT scan. Also, the diagnosis of CRC was based on NCCN clinical practice guidelines in oncology. Blood samples were taken before treatment during routine testing. A 5 mL of peripheral blood was collected from each patient. All patients signed the written consent for the study. Also, a total of 40 healthy subjects were selected as healthy controls from the same area during a routine physical examination, which was also confirmed by screening colonoscopy and pathology. Serum TCh and TG levels were quantitatively determined by the colorimetric method. LDL-C and HDL-C were determined by the turbidimetric immunoassay. Steroid hormones were quantitatively determined by the Enzyme-linked immunosorbent assay (ELISA) according to the reagent manufacturer’s instruction. To analyze data, the SPSS software package (version 21) was applied. Results: Among all the indicators studied, the (mean ± SD) of testosterone, FSH and LH levels was higher (1.85 ± 1.63 ng/ml, 15.35 ± 0.13mIU/l, 12.42 ± 0.12.16mIU/ml) in patients with CRC than (mean ± SD) healthy controls (0.40 ± 0.21ng/ml, 6.27 ± 0.50mIU/ml, 2.89 ± 0.20mIU/ml, P < 0.05), respectively. Also, the results in subgroups showed that the mean testosterone (0.91 ± 1.2ng/l), FSH (19.11 ± 16mIU/ml), LH (14.49 ± 14mIU/ml) levels in the woman patients with CRC was higher than healthy female controls and had more statistical significance (p = 0.02, 0.00, 0.00), respectively. The area under the AUC cure (Figure 1) of the testosterone, FSH, and LH indicates positive test (0.670, 0.726 and 0.775). Conclusions: Changes in the levels of steroid hormones and lipids could correlate with the elevated chance of CRC. Therefore, assessment of multiple markers might overcome and provide better judgment in patients with CRC.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133407115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Payandeh, M. Peeri, M. Azarbayjani, S. Hosseini
Background: A healthy lifestyle, nutrition, and exercise can improve bone mass via several mechanisms. Objectives: This study assessed the effects of four weeks of palm pollen consumption along with resistance training on protein and gene expression levels of Runt-related transcription factor 2 (Runx2) in bone tissue of rats. Methods: Thirty-six rats were selected and assigned into six groups, including (1) training + testosterone, (2) training + palm pollen, (3) testosterone, (4) palm pollen, (5) training and (6) sham. Then, 100 mg/kg of palm pollen was prescribed five days per week. Resistance training was performed five sessions per week, and 2 mg/kg of testosterone propionate was prescribed peritoneally. Gene expression and protein levels of Runx2 were measured via the real-time PCR and Western blot methods. Results: Training had a significant effect on the increase in Runx2 protein levels (P ≤ 0.05). Training + testosterone, training + palm pollen, testosterone, and palm pollen had significant effects on gene expression and protein levels of Runx2 (P ≤ 0.05). Training + testosterone and training + palm pollen had more favorable effects on the increase of gene expression and protein levels of Runx2 than had testosterone, palm pollen, and training (P ≤ 0.05). Conclusions: Although training, palm pollen, and testosterone alone could increase the Runx2 protein levels in the bone tissue of rats, training with palm pollen and training with testosterone appeared to have more favorable effects on the increase of gene expression and protein levels of Runx2 than either alone.
{"title":"Effect of Resistance Training with Palm Pollen and Testosterone on Runx2 Protein and Gene Expression Levels in Bone Tissue of Adult Male Rats","authors":"N. Payandeh, M. Peeri, M. Azarbayjani, S. Hosseini","doi":"10.5812/hmj.105332","DOIUrl":"https://doi.org/10.5812/hmj.105332","url":null,"abstract":"Background: A healthy lifestyle, nutrition, and exercise can improve bone mass via several mechanisms. Objectives: This study assessed the effects of four weeks of palm pollen consumption along with resistance training on protein and gene expression levels of Runt-related transcription factor 2 (Runx2) in bone tissue of rats. Methods: Thirty-six rats were selected and assigned into six groups, including (1) training + testosterone, (2) training + palm pollen, (3) testosterone, (4) palm pollen, (5) training and (6) sham. Then, 100 mg/kg of palm pollen was prescribed five days per week. Resistance training was performed five sessions per week, and 2 mg/kg of testosterone propionate was prescribed peritoneally. Gene expression and protein levels of Runx2 were measured via the real-time PCR and Western blot methods. Results: Training had a significant effect on the increase in Runx2 protein levels (P ≤ 0.05). Training + testosterone, training + palm pollen, testosterone, and palm pollen had significant effects on gene expression and protein levels of Runx2 (P ≤ 0.05). Training + testosterone and training + palm pollen had more favorable effects on the increase of gene expression and protein levels of Runx2 than had testosterone, palm pollen, and training (P ≤ 0.05). Conclusions: Although training, palm pollen, and testosterone alone could increase the Runx2 protein levels in the bone tissue of rats, training with palm pollen and training with testosterone appeared to have more favorable effects on the increase of gene expression and protein levels of Runx2 than either alone.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131623832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Yousefi, Fariba Asadi Noghabi, Samere Farhani Nejad, Mohsen yousefi
Background: The velocity of providing services in health centers is crucial to reduce mortality and adverse outcomes. Objectives: The present study aimed at determining the waiting time from entering the emergency department (ED) up to physician visiting based on congestion in the triple shift at Shahid Mohammadi Hospital in Bandar Abbas, Iran. Methods: The current cross-sectional, analytical study was conducted in 2019 on 1285 subjects selected from three shifts. The data collection tools included demographic data and standard triage forms, as well as a timetable with a stopwatch. The time between patient arrival and physician visit was recorded. SPSS software version 21 was employed to analyze the data. Results: The highest percentage of patients, 65.1% (n = 837), was non-traumatic, 38.98% (n = 501) referred during the evening shift, and 47.54% (n = 611) were related to the triage level 3. The maximum average waiting time from the beginning to the end of the triage was 4.46, and up to the physician, the visit was 12.8 minutes. Waiting time from entering ED up to physician first visit in terms of gender, refer to ED, and cause of referral statistically divulged a significant difference (P < 0.05). Estimation of the maximum congestion in the department was from 16:00 to 20:00, which showed a significant difference with other day times (P < 0.05). Conclusions: The average waiting time for patients was higher than the global standard. The interventions based on the maximum congestion in ED can be effective in reducing patient waiting time.
{"title":"Evaluation of Patient Flow and Waiting Time for the First Physician Visit in an Overcrowded Emergency Department","authors":"H. Yousefi, Fariba Asadi Noghabi, Samere Farhani Nejad, Mohsen yousefi","doi":"10.5812/hmj.96215","DOIUrl":"https://doi.org/10.5812/hmj.96215","url":null,"abstract":"Background: The velocity of providing services in health centers is crucial to reduce mortality and adverse outcomes. Objectives: The present study aimed at determining the waiting time from entering the emergency department (ED) up to physician visiting based on congestion in the triple shift at Shahid Mohammadi Hospital in Bandar Abbas, Iran. Methods: The current cross-sectional, analytical study was conducted in 2019 on 1285 subjects selected from three shifts. The data collection tools included demographic data and standard triage forms, as well as a timetable with a stopwatch. The time between patient arrival and physician visit was recorded. SPSS software version 21 was employed to analyze the data. Results: The highest percentage of patients, 65.1% (n = 837), was non-traumatic, 38.98% (n = 501) referred during the evening shift, and 47.54% (n = 611) were related to the triage level 3. The maximum average waiting time from the beginning to the end of the triage was 4.46, and up to the physician, the visit was 12.8 minutes. Waiting time from entering ED up to physician first visit in terms of gender, refer to ED, and cause of referral statistically divulged a significant difference (P < 0.05). Estimation of the maximum congestion in the department was from 16:00 to 20:00, which showed a significant difference with other day times (P < 0.05). Conclusions: The average waiting time for patients was higher than the global standard. The interventions based on the maximum congestion in ED can be effective in reducing patient waiting time.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130115587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nahid Davoodian, Maryam Arab Firouzjaei, A. Negahi
: The novel Coronavirus Disease 2019 (COVID-19) is a highly contagious virus that has caused tremendous chaos in the world. Generally, respiratory symptoms are dominant manifestations in patients with COVID-19. However, the involvement of other organs, such as the nervous system has also been reported, which elucidates the capability of the virus to induce multi-organ failure. In this regard, the presentation of neurological symptoms in infected patients has raised the concern regarding the neuroinvasive potential of COVID-19. As of today, there is emerging evidence that supports the susceptibility of the nervous system to COVID-19. Undoubtedly, the awareness of these findings can result in the timely management and treatment of patients. In the present article, we documented a brief overview of neurological manifestations, possible neuroinvasion mechanisms of COVID-19, and the management of neurological symptoms in infected patients.
{"title":"Neurological Involvement of Patients with COVID-19: Proposed Neuroinvasive Mechanisms and Management","authors":"Nahid Davoodian, Maryam Arab Firouzjaei, A. Negahi","doi":"10.5812/HMJ.107977","DOIUrl":"https://doi.org/10.5812/HMJ.107977","url":null,"abstract":": The novel Coronavirus Disease 2019 (COVID-19) is a highly contagious virus that has caused tremendous chaos in the world. Generally, respiratory symptoms are dominant manifestations in patients with COVID-19. However, the involvement of other organs, such as the nervous system has also been reported, which elucidates the capability of the virus to induce multi-organ failure. In this regard, the presentation of neurological symptoms in infected patients has raised the concern regarding the neuroinvasive potential of COVID-19. As of today, there is emerging evidence that supports the susceptibility of the nervous system to COVID-19. Undoubtedly, the awareness of these findings can result in the timely management and treatment of patients. In the present article, we documented a brief overview of neurological manifestations, possible neuroinvasion mechanisms of COVID-19, and the management of neurological symptoms in infected patients.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"367 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131640383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Rahkar Farshi, M. Jabraeili, N. Moharrami, J. Malakouti
Introduction: Children are sensitive at any age to coronavirus disease 2019 (COVID-19) and are at risk of being infected. The prevalence of this disease in children under ten years of age is reported to be 1%. The most common clinical manifestation of COVID-19 in children is acute respiratory distress syndrome (ARDS). Nursing management is an important part of the treatment in children with ARDS. Owing to the emergence of COVID-19 and less focus on studies in pediatrics, the present study reports a case of COVID-19 in an 8-year-old child and its caring issues. Case Presentation: This report describes an 8-year-old boy who was referred to Tabriz Children’s Hospital with respiratory symptoms such as fever, cough, and dyspnea. He was admitted to the pediatric intensive care unit. Diagnosis of COVID-19 was made based on the PCR test on the second day of hospitalization. In chest X-ray imaging, in the left lung, consolidation, and glass-opacity was observed. Conclusions: Caring for a child with COVID-19 was a new experience for PICU nurses. The most important caring issues of a child with COVID-19 were continuous monitoring of respiratory status, paying more attention to family informational and emotional support owing to visitation bans, transmission of infection, and the difficulty of caring activities due to the limitations of the use of personal protective equipment.
{"title":"Nursing Care in a Child with Coronavirus Disease 2019: A Case Study","authors":"M. Rahkar Farshi, M. Jabraeili, N. Moharrami, J. Malakouti","doi":"10.5812/HMJ.108040","DOIUrl":"https://doi.org/10.5812/HMJ.108040","url":null,"abstract":"Introduction: Children are sensitive at any age to coronavirus disease 2019 (COVID-19) and are at risk of being infected. The prevalence of this disease in children under ten years of age is reported to be 1%. The most common clinical manifestation of COVID-19 in children is acute respiratory distress syndrome (ARDS). Nursing management is an important part of the treatment in children with ARDS. Owing to the emergence of COVID-19 and less focus on studies in pediatrics, the present study reports a case of COVID-19 in an 8-year-old child and its caring issues. Case Presentation: This report describes an 8-year-old boy who was referred to Tabriz Children’s Hospital with respiratory symptoms such as fever, cough, and dyspnea. He was admitted to the pediatric intensive care unit. Diagnosis of COVID-19 was made based on the PCR test on the second day of hospitalization. In chest X-ray imaging, in the left lung, consolidation, and glass-opacity was observed. Conclusions: Caring for a child with COVID-19 was a new experience for PICU nurses. The most important caring issues of a child with COVID-19 were continuous monitoring of respiratory status, paying more attention to family informational and emotional support owing to visitation bans, transmission of infection, and the difficulty of caring activities due to the limitations of the use of personal protective equipment.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"165 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121032278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Mani, Leila Khabir, Laya Ahmadzadeh, S. Soltani, Shohre Asadollahi
Background: Binge eating is the consumption of a large amount of food, with the feeling of loss of control. Unhealthy eating behaviors, especially binge eating disorder, may be a form of coping strategies to control the negative and unpleasant feelings. Objectives: The present study was conducted to investigate the differences in avoidance coping strategies among female college students with binge eating disorder and healthy controls. Methods: A cross-sectional study was conducted on 200 female students who entered Shiraz University of Medical Sciences in 2011. Data were obtained via the Binge Eating scale (BES) and Lazarus’ ways of the coping questionnaire. We collected the demographic characteristics of the students, such as age, year of the entrance, living place, and mean score of the last semester from the checklist. We used descriptive statistics and independent t-test to evaluate the overeating and normal groups of collegian students. Results: The mean age of the participants was 22.94 ± 1.94 years. In this study, 75% of the individuals were normal, and the remainder was in the overeating group. Based on Lazarus’ ways of the coping questionnaire, confronting coping (P < 0.02) and escape-avoidance (P < 0.01), subscales showed a significant difference between the overeating and normal groups. In both subscales, the overeating group had lower scores. In the end, the mean scores of the overeating and normal groups were significantly different (P < 0.001). Conclusions: The use of inefficient coping strategies increased the negative outcomes such as binge eating disorder in students. Avoidance coping strategy can be an essential mechanism used to reduce the pressures in stressful situations.
{"title":"Comparison of Avoidance Coping Strategies Among Female College Students with Binge Eating and Healthy Controls","authors":"A. Mani, Leila Khabir, Laya Ahmadzadeh, S. Soltani, Shohre Asadollahi","doi":"10.5812/HMJ.102641","DOIUrl":"https://doi.org/10.5812/HMJ.102641","url":null,"abstract":"Background: Binge eating is the consumption of a large amount of food, with the feeling of loss of control. Unhealthy eating behaviors, especially binge eating disorder, may be a form of coping strategies to control the negative and unpleasant feelings. Objectives: The present study was conducted to investigate the differences in avoidance coping strategies among female college students with binge eating disorder and healthy controls. Methods: A cross-sectional study was conducted on 200 female students who entered Shiraz University of Medical Sciences in 2011. Data were obtained via the Binge Eating scale (BES) and Lazarus’ ways of the coping questionnaire. We collected the demographic characteristics of the students, such as age, year of the entrance, living place, and mean score of the last semester from the checklist. We used descriptive statistics and independent t-test to evaluate the overeating and normal groups of collegian students. Results: The mean age of the participants was 22.94 ± 1.94 years. In this study, 75% of the individuals were normal, and the remainder was in the overeating group. Based on Lazarus’ ways of the coping questionnaire, confronting coping (P < 0.02) and escape-avoidance (P < 0.01), subscales showed a significant difference between the overeating and normal groups. In both subscales, the overeating group had lower scores. In the end, the mean scores of the overeating and normal groups were significantly different (P < 0.001). Conclusions: The use of inefficient coping strategies increased the negative outcomes such as binge eating disorder in students. Avoidance coping strategy can be an essential mechanism used to reduce the pressures in stressful situations.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130461845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Hejazi, Seyyed Reza Attarzadeh Hosseini, M. Fathi, Mohammad Mosaferi Ziaaldini
Background: The lack of physical activity and obesity causes mild chronic inflammation that is associated with increased plasma levels of inflammatory markers. Evidence suggests that physical activity can reduce inflammatory markers. Objectives: The purpose of this study was to determine the effects of eight weeks of aerobic training with two intensities on levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and insulin resistance in obese Wistar rats. Methods: Twenty-four Wistar male rats (fourteen weeks old and weighing 250 - 300 g, body mass index > 30 g/cm2) were used. After two weeks of familiarity with the laboratory environment, the animals were randomly divided into three groups: (1) high-intensity aerobic exercise (n = 8); (2) moderate-intensity aerobic exercise (n = 8), and control (n = 8). The rats in moderate and high-intensity aerobic exercise groups were performed an increasing training for eight weeks and five days a week and one session per day for 60 minutes running at different speeds on a rodent motor-driven treadmill. Data were analyzed by paired sample t-test and repeated measures (ANOVA) for the inter-group and intra-group comparison of the variance changes. Results: Significant differences were found in serum TNF-α levels (P = 0.027 and F = 3.42), IL-6 levels (P = 0.043 and F = 2.99), and insulin resistance index (P = 0.008 and F = 4.69) between the moderate, high-intensity aerobic exercises, and control groups. The levels of TNF-α concentration was significantly different between moderate-intensity and control group (P = 0.01) and between the high-intensity and control groups (P = 0.01). The insulin resistance index in MI (P = 0.01) and HI (P = 0.01) groups significantly decreased compared to the control group. Conclusions: The results of the present study show that both types of moderate-intensity and high-intensity aerobic exercise lead to the reduction of TNF-α, interleukin-6, and insulin resistance index compared to the control group. Further studies are needed to shed light on the effects of different types of exercise on such indices, especially the use of long-term training sessions.
{"title":"Inflammatory Markers in Response to Different Intensity of Aerobic Exercise in Obese Male Wistar Rats","authors":"K. Hejazi, Seyyed Reza Attarzadeh Hosseini, M. Fathi, Mohammad Mosaferi Ziaaldini","doi":"10.5812/hmj.101699","DOIUrl":"https://doi.org/10.5812/hmj.101699","url":null,"abstract":"Background: The lack of physical activity and obesity causes mild chronic inflammation that is associated with increased plasma levels of inflammatory markers. Evidence suggests that physical activity can reduce inflammatory markers. Objectives: The purpose of this study was to determine the effects of eight weeks of aerobic training with two intensities on levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and insulin resistance in obese Wistar rats. Methods: Twenty-four Wistar male rats (fourteen weeks old and weighing 250 - 300 g, body mass index > 30 g/cm2) were used. After two weeks of familiarity with the laboratory environment, the animals were randomly divided into three groups: (1) high-intensity aerobic exercise (n = 8); (2) moderate-intensity aerobic exercise (n = 8), and control (n = 8). The rats in moderate and high-intensity aerobic exercise groups were performed an increasing training for eight weeks and five days a week and one session per day for 60 minutes running at different speeds on a rodent motor-driven treadmill. Data were analyzed by paired sample t-test and repeated measures (ANOVA) for the inter-group and intra-group comparison of the variance changes. Results: Significant differences were found in serum TNF-α levels (P = 0.027 and F = 3.42), IL-6 levels (P = 0.043 and F = 2.99), and insulin resistance index (P = 0.008 and F = 4.69) between the moderate, high-intensity aerobic exercises, and control groups. The levels of TNF-α concentration was significantly different between moderate-intensity and control group (P = 0.01) and between the high-intensity and control groups (P = 0.01). The insulin resistance index in MI (P = 0.01) and HI (P = 0.01) groups significantly decreased compared to the control group. Conclusions: The results of the present study show that both types of moderate-intensity and high-intensity aerobic exercise lead to the reduction of TNF-α, interleukin-6, and insulin resistance index compared to the control group. Further studies are needed to shed light on the effects of different types of exercise on such indices, especially the use of long-term training sessions.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132075485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Anxiety in patients admitted at the Intensive Care Unit (ICU) is common and usually moderate or severe. Anxiety affects endocrine and physiological responses. Objectives: This study aimed to determine the effect of aromatherapy by rose essence on anxiety and physiological indices of conscious patients admitted at ICU. Methods: In this clinical trial, 60 conscious patients admitted at ICU wards in Ali Ibn Abi Talib Hospital of Rafsanjan were selected and randomly allocated into two groups of intervention and control. In the intervention group, three drops of 10% rose essence were poured on the gauze and placed 20 cm from the patients’ nose on their shirt, and the patients inhaled it for 20 minutes three times a day. In the control group, three drops of distilled water were used likewise. Data collection tools included Spielberger State-Trait Anxiety Inventory (STAI) and the demographic questionnaire. Data were analyzed using SPSS V.18. Results: According to the results, in the intervention group, the systolic and diastolic blood pressure significantly increased (paired t-test, P < 0.05) in the second time after the intervention and significantly decreased (paired t-test, P < 0.05) in the third time. The mean oxygen saturation of arterial blood also significantly increased in the second time in this group after the intervention (paired t-test, P = 0.001). However, there was no significant difference in anxiety score before and after the intervention in each group. Conclusions: Although aromatherapy using rose essence was statistically significant on some of the physiological indices of conscious patients in ICU, these differences were not clinically significant.
背景:在重症监护病房(ICU)住院的患者中，焦虑是常见的，通常是中度或重度。焦虑影响内分泌和生理反应。目的:探讨玫瑰香薰对ICU清醒患者焦虑及生理指标的影响。方法:选取拉夫桑詹市Ali Ibn Abi Talib医院ICU病房收治的神志清醒患者60例，随机分为干预组和对照组。干预组将10%玫瑰香精滴3滴在纱布上，放置在距患者鼻子20厘米处的衬衫上，患者每天吸入3次，每次20分钟。在对照组中，同样使用三滴蒸馏水。数据收集工具包括Spielberger状态-特质焦虑量表(STAI)和人口统计问卷。数据采用SPSS V.18进行分析。结果:干预组患者干预后第二次收缩压、舒张压显著升高(配对t检验，P < 0.05)，第三次收缩压显著降低(配对t检验，P < 0.05)。干预后，本组第二次动脉血平均氧饱和度显著升高(配对t检验，P = 0.001)。但各组干预前后焦虑评分差异无统计学意义。结论:玫瑰香精芳香疗法对ICU清醒患者的部分生理指标有统计学意义，但临床差异无统计学意义。
{"title":"The Effect of Aromatherapy by Rose Essence on Anxiety and Physiological Indices of Conscious Patients Admitted at Intensive Care Units","authors":"N. Zare, M. Shahabinejad, T. Sadeghi","doi":"10.5812/hmj.101124","DOIUrl":"https://doi.org/10.5812/hmj.101124","url":null,"abstract":"Background: Anxiety in patients admitted at the Intensive Care Unit (ICU) is common and usually moderate or severe. Anxiety affects endocrine and physiological responses. Objectives: This study aimed to determine the effect of aromatherapy by rose essence on anxiety and physiological indices of conscious patients admitted at ICU. Methods: In this clinical trial, 60 conscious patients admitted at ICU wards in Ali Ibn Abi Talib Hospital of Rafsanjan were selected and randomly allocated into two groups of intervention and control. In the intervention group, three drops of 10% rose essence were poured on the gauze and placed 20 cm from the patients’ nose on their shirt, and the patients inhaled it for 20 minutes three times a day. In the control group, three drops of distilled water were used likewise. Data collection tools included Spielberger State-Trait Anxiety Inventory (STAI) and the demographic questionnaire. Data were analyzed using SPSS V.18. Results: According to the results, in the intervention group, the systolic and diastolic blood pressure significantly increased (paired t-test, P < 0.05) in the second time after the intervention and significantly decreased (paired t-test, P < 0.05) in the third time. The mean oxygen saturation of arterial blood also significantly increased in the second time in this group after the intervention (paired t-test, P = 0.001). However, there was no significant difference in anxiety score before and after the intervention in each group. Conclusions: Although aromatherapy using rose essence was statistically significant on some of the physiological indices of conscious patients in ICU, these differences were not clinically significant.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134423122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: A sedentary lifestyle can result in chronic inflammation, which is a risk factor for Cardiovascular Disease (CVD). Lifestyle modifications, including physical activity and herbal supplements, may have health benefits. Objectives: The present study aimed to investigate the effect of regular exercise and garlic consumption on some inflammatory biomarkers in sedentary overweight individuals. Methods: Forty-four sedentary overweight male participants (20 - 30 years) were randomized to the following groups: Exercise + garlic (ES), exercise + placebo (E), garlic (G), and placebo (P). The training protocol included 20 - 45 minutes of walking/running at 60 to 75% of the maximum heart rate, three sessions per week for eight weeks. Participants consumed two capsules containing 500 milligrams of garlic powder or placebo (starch) per day. Before and 48 h after the exercise intervention and supplement administration, blood samples were collected to assess the hs-CRP and TNF-α serum levels. One-way ANOVA and Tukey’s post hoc tests were used to analyze the data at a significance level of P < 0.05. Results: A significant difference was observed between the groups regarding the hs-CRP and TNF-α levels after the experimental period (P < 0.05). There was a significant difference between EG and placebo groups (P < 0.05). Conclusions: Based on the findings, garlic consumption, along with exercise training could exert anti-inflammatory properties in overweight subjects.
{"title":"Anti-Inflammatory Effects of Garlic Consumption and Regular Exercise in Sedentary Overweight Individuals","authors":"F. Gholami, J. Bashiri, Naser Amanollahi","doi":"10.5812/hmj.103143","DOIUrl":"https://doi.org/10.5812/hmj.103143","url":null,"abstract":"Background: A sedentary lifestyle can result in chronic inflammation, which is a risk factor for Cardiovascular Disease (CVD). Lifestyle modifications, including physical activity and herbal supplements, may have health benefits. Objectives: The present study aimed to investigate the effect of regular exercise and garlic consumption on some inflammatory biomarkers in sedentary overweight individuals. Methods: Forty-four sedentary overweight male participants (20 - 30 years) were randomized to the following groups: Exercise + garlic (ES), exercise + placebo (E), garlic (G), and placebo (P). The training protocol included 20 - 45 minutes of walking/running at 60 to 75% of the maximum heart rate, three sessions per week for eight weeks. Participants consumed two capsules containing 500 milligrams of garlic powder or placebo (starch) per day. Before and 48 h after the exercise intervention and supplement administration, blood samples were collected to assess the hs-CRP and TNF-α serum levels. One-way ANOVA and Tukey’s post hoc tests were used to analyze the data at a significance level of P < 0.05. Results: A significant difference was observed between the groups regarding the hs-CRP and TNF-α levels after the experimental period (P < 0.05). There was a significant difference between EG and placebo groups (P < 0.05). Conclusions: Based on the findings, garlic consumption, along with exercise training could exert anti-inflammatory properties in overweight subjects.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"222 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134119433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Do Public People Need to Use Mask in the Fight Against COVID-19?","authors":"A. Tajvar, Ali Mouseli, Hamid Reza Ghaffari","doi":"10.5812/hmj.106060","DOIUrl":"https://doi.org/10.5812/hmj.106060","url":null,"abstract":"<jats:p />","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128578164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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