Mahmood Hosseinpoor, Sajjad Fekrijaski, S. Zare, M. Soleimani-Ahmadi
Background: Currently, Iran has entered the malaria elimination phase, and no malaria cases have been observed in this country during the last two consecutive years. Continuous monitoring and analysis of the malaria situation are necessary to achieve the elimination goals set to be achieved in 2025. This study aimed to determine the malaria situation analysis during the implementation of the elimination programme in Jask county, one of the most important malaria foci in Iran. Methods: This descriptive-analytical study was conducted in Jask county of Hormozgan province in the southeast of Iran from 2010 to 2020. Data were collected from the national malaria surveillance system and special forms that were completed by malaria focal points in Jask county. Data were analyzed using SPSS 21 software and descriptive statistics. Results: A total of 347 confirmed malaria cases were recorded, and the total number of cases was found to decrease from 114 cases in 2010 to 11 in 2020. The mean age of the patients was 23.4±19.6 years, and most cases (74.06%) belonged to 15-year-old or older people. Plasmodium vivax was the most prevalent species (83.86%). Based on the results, males were more infected (81.84%) than females, and the majority of the patients were from rural areas (86.4%). Conclusion: Malaria incidence has significantly decreased during the past eleven years in Jask county. The considerable drop in the incidence of malaria may be related to the implementation of comprehensive malaria control measures and intensive entomological and parasitological monitoring.
{"title":"Analysis of Malaria Situation in Jask County During the Implementation of the Elimination Programme in 2010-2020","authors":"Mahmood Hosseinpoor, Sajjad Fekrijaski, S. Zare, M. Soleimani-Ahmadi","doi":"10.34172/hmj.2023.3030","DOIUrl":"https://doi.org/10.34172/hmj.2023.3030","url":null,"abstract":"Background: Currently, Iran has entered the malaria elimination phase, and no malaria cases have been observed in this country during the last two consecutive years. Continuous monitoring and analysis of the malaria situation are necessary to achieve the elimination goals set to be achieved in 2025. This study aimed to determine the malaria situation analysis during the implementation of the elimination programme in Jask county, one of the most important malaria foci in Iran. Methods: This descriptive-analytical study was conducted in Jask county of Hormozgan province in the southeast of Iran from 2010 to 2020. Data were collected from the national malaria surveillance system and special forms that were completed by malaria focal points in Jask county. Data were analyzed using SPSS 21 software and descriptive statistics. Results: A total of 347 confirmed malaria cases were recorded, and the total number of cases was found to decrease from 114 cases in 2010 to 11 in 2020. The mean age of the patients was 23.4±19.6 years, and most cases (74.06%) belonged to 15-year-old or older people. Plasmodium vivax was the most prevalent species (83.86%). Based on the results, males were more infected (81.84%) than females, and the majority of the patients were from rural areas (86.4%). Conclusion: Malaria incidence has significantly decreased during the past eleven years in Jask county. The considerable drop in the incidence of malaria may be related to the implementation of comprehensive malaria control measures and intensive entomological and parasitological monitoring.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122300253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Javad Parniani, Zeynab Shahsavari, S. Jafari, Mohammad Zamani Rarani, Reza Afzalipour
Background: Although radiography tests are beneficial in diagnosing various diseases, they have some risks for patients and radiology staff, which will be minimized if observing radiation protection standards. The purpose of this study was to evaluate the knowledge, attitude, and performance of radiographers regarding radiation protection in the radiology departments of Bandar Abbas. Methods: This work was performed as a descriptive-analytical study. A questionnaire consisting of 38 items was distributed among all radiographers in Bandar Abbas. Information obtained from the questionnaires was analyzed by appropriate nonparametric tests and Spearman’s correlation coefficient. The Kolmogorov-Smirnov test was used to normalize the distribution of scores. Finally, linear regression was employed to determine the effect of each independent variable on the knowledge score. Results: The participation rate of radiographers was 53.9%. The means and standard deviations of scores assigned to attitude, knowledge, and performance in the field of radiation protection were 65.36±27.11, 36.36±17.72, and 46.66±19.60, respectively. The relationship between age and experience of radiographers with their attitude, knowledge, and practice was significant (P>0.05). In addition, there was a significant difference between their attitudes in terms of the place of service (P<0.05). Conclusion: The results of this study revealed that radiographers with different levels of age, education, and work experience have almost the same level of knowledge, attitude, and practice. They had an appropriate attitude and practice in the field of radiation protection.
{"title":"Assessing the Level of Knowledge, Attitude, and Performance of Radiographers About Radiation Protection in Bandar Abbas, Iran","authors":"Javad Parniani, Zeynab Shahsavari, S. Jafari, Mohammad Zamani Rarani, Reza Afzalipour","doi":"10.34172/hmj.2023.1975","DOIUrl":"https://doi.org/10.34172/hmj.2023.1975","url":null,"abstract":"Background: Although radiography tests are beneficial in diagnosing various diseases, they have some risks for patients and radiology staff, which will be minimized if observing radiation protection standards. The purpose of this study was to evaluate the knowledge, attitude, and performance of radiographers regarding radiation protection in the radiology departments of Bandar Abbas. Methods: This work was performed as a descriptive-analytical study. A questionnaire consisting of 38 items was distributed among all radiographers in Bandar Abbas. Information obtained from the questionnaires was analyzed by appropriate nonparametric tests and Spearman’s correlation coefficient. The Kolmogorov-Smirnov test was used to normalize the distribution of scores. Finally, linear regression was employed to determine the effect of each independent variable on the knowledge score. Results: The participation rate of radiographers was 53.9%. The means and standard deviations of scores assigned to attitude, knowledge, and performance in the field of radiation protection were 65.36±27.11, 36.36±17.72, and 46.66±19.60, respectively. The relationship between age and experience of radiographers with their attitude, knowledge, and practice was significant (P>0.05). In addition, there was a significant difference between their attitudes in terms of the place of service (P<0.05). Conclusion: The results of this study revealed that radiographers with different levels of age, education, and work experience have almost the same level of knowledge, attitude, and practice. They had an appropriate attitude and practice in the field of radiation protection.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123017480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyed Amir Hosain Diba Hosaini, Morvarid Vafaee, B. Abedi
Background: Irisin is a myokine suggested to exert anti-obesity benefits. On the other hand, paraxonase-1 (PON 1) is one of the most important free radical scavenging enzymes and is among the main protectors of lipoproteins against oxidizing compounds. This study aimed to evaluate the effect of 8 weeks of concurrent training on serum levels of irisin, PON 1, lipid profile, and insulin resistance in men with metabolic syndrome. Methods: In this quasi-experimental study, 30 men with metabolic syndrome (aged 25-35 years and with body mass>25 kg.m-2) were purposefully selected and randomly divided into two groups of concurrent training (n=15) and control (n=15). Three sessions of the training program were held per week over an 8-week interval. Concurrent training included warm-up, resistance (20 minutes of resistance training), and endurance (25 minutes of activity on a stationary bike with an intensity of 50%-80% of maximum heart rate). Blood samples were collected before and 24 hours after exercise to measure serum levels of variables. Data were analyzed using independent and dependent t-tests. Results: At baseline, serum levels of PON 1, irisin, and high-density lipoprotein (HDL) were higher in the concurrent training group. The results of the study also indicated that 8 weeks of concurrent training significantly reduced the levels of insulin resistance, triglycerides (TG), cholesterol, low-density lipoprotein (LDL), systolic, and diastolic blood pressure in men with metabolic syndrome. Conclusion: Eight weeks of concurrent training improves the levels of irisin, insulin resistance, PON 1, and lipid profile of men with metabolic syndrome.
{"title":"The Effect of Eight Weeks of Concurrent Training on Serum Levels of Paraxonase-1, Irisin, Lipid Profile, and Insulin Resistance in Men With Metabolic Syndrome","authors":"Seyed Amir Hosain Diba Hosaini, Morvarid Vafaee, B. Abedi","doi":"10.34172/hmj.2022.8188","DOIUrl":"https://doi.org/10.34172/hmj.2022.8188","url":null,"abstract":"Background: Irisin is a myokine suggested to exert anti-obesity benefits. On the other hand, paraxonase-1 (PON 1) is one of the most important free radical scavenging enzymes and is among the main protectors of lipoproteins against oxidizing compounds. This study aimed to evaluate the effect of 8 weeks of concurrent training on serum levels of irisin, PON 1, lipid profile, and insulin resistance in men with metabolic syndrome. Methods: In this quasi-experimental study, 30 men with metabolic syndrome (aged 25-35 years and with body mass>25 kg.m-2) were purposefully selected and randomly divided into two groups of concurrent training (n=15) and control (n=15). Three sessions of the training program were held per week over an 8-week interval. Concurrent training included warm-up, resistance (20 minutes of resistance training), and endurance (25 minutes of activity on a stationary bike with an intensity of 50%-80% of maximum heart rate). Blood samples were collected before and 24 hours after exercise to measure serum levels of variables. Data were analyzed using independent and dependent t-tests. Results: At baseline, serum levels of PON 1, irisin, and high-density lipoprotein (HDL) were higher in the concurrent training group. The results of the study also indicated that 8 weeks of concurrent training significantly reduced the levels of insulin resistance, triglycerides (TG), cholesterol, low-density lipoprotein (LDL), systolic, and diastolic blood pressure in men with metabolic syndrome. Conclusion: Eight weeks of concurrent training improves the levels of irisin, insulin resistance, PON 1, and lipid profile of men with metabolic syndrome.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116024120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Majid Najafi-Asl, S. Hosseini Teshnizi, Maryam Sarani, M. Teremahi Ardestani, K. Sharifi-Sarasiabi
Background: Diarrheal diseases are the major causes of morbidity and mortality in developing countries and the second most common cause of death in children under five years. The main objective of the study was to determine the prevalence of intestinal parasites in diarrheal patients in Bandar Abbas, Southern Iran. Methods: This cross-sectional study was conducted to assess the prevalence of intestinal parasitic infections and associated factors among patients with diarrhea in the major hospitals of Bandar Abbas. A single fecal specimen was collected from 170 diarrheic patients from October 2018 to May 2019. The diagnosis was made based on the direct wet mount and formalin-ether concentration method. Trichrome and modified acid-fast staining methods were used for the better detection of protozoa. The collected data were analyzed using SPSS software. Results: A total of 170 stool specimens were collected from diarrheic patients. Of these, 57.6% were males and 42.4% were females. The overall prevalence of intestinal parasites was 12.9%. The most prevalent parasite was Blastocystis spp. 10 (5.9%), followed by Giardia lamblia 7 (4.1%), Cryptosporidium spp. 3 (1.8%), Entamoeba coli 1 (0.6%), and Hymenolepis nana 1 (0.6%). Conclusion: Overall, the results showed that intestinal parasites, especially helminth infections, have significantly decreased in recent years.
{"title":"Intestinal Parasites in Diarrheal Patients in Bandar Abbas, Southern Iran","authors":"Majid Najafi-Asl, S. Hosseini Teshnizi, Maryam Sarani, M. Teremahi Ardestani, K. Sharifi-Sarasiabi","doi":"10.34172/hmj.2022.970","DOIUrl":"https://doi.org/10.34172/hmj.2022.970","url":null,"abstract":"Background: Diarrheal diseases are the major causes of morbidity and mortality in developing countries and the second most common cause of death in children under five years. The main objective of the study was to determine the prevalence of intestinal parasites in diarrheal patients in Bandar Abbas, Southern Iran. Methods: This cross-sectional study was conducted to assess the prevalence of intestinal parasitic infections and associated factors among patients with diarrhea in the major hospitals of Bandar Abbas. A single fecal specimen was collected from 170 diarrheic patients from October 2018 to May 2019. The diagnosis was made based on the direct wet mount and formalin-ether concentration method. Trichrome and modified acid-fast staining methods were used for the better detection of protozoa. The collected data were analyzed using SPSS software. Results: A total of 170 stool specimens were collected from diarrheic patients. Of these, 57.6% were males and 42.4% were females. The overall prevalence of intestinal parasites was 12.9%. The most prevalent parasite was Blastocystis spp. 10 (5.9%), followed by Giardia lamblia 7 (4.1%), Cryptosporidium spp. 3 (1.8%), Entamoeba coli 1 (0.6%), and Hymenolepis nana 1 (0.6%). Conclusion: Overall, the results showed that intestinal parasites, especially helminth infections, have significantly decreased in recent years.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128744641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Khademi, Elham Imani, Manigeh Sayadi Manghalati
Background: In the context of the coronavirus disease 2019 (COVID-19) pandemic, frontline nurses were active in this event and faced numerous challenges. This study aimed to discover the emotional challenges nurses faced on shifts in COVID-19 wards. Methods: In this phenomenological qualitative research, purposive sampling was used to collect the data. A phone interview was conducted with nurses who worked in COVID-19 wards in five Medical Science Universities in Iran in 2020. Then, the recorded interviews were written down. Findings were analyzed using a 6-step thematic analysis guided by Van Manen’s hermeneutic phenomenological approach. The validity and reliability of the study were assessed based on the four criteria proposed by Lincoln and Guba: credibility, dependability, confirmability, and transformability of data. Results: According to analyzed data obtained from interviews with 15 nurses working in the COVID-19 ward, the age average of participants was about 32±5.05. The thematic analysis consisted of four themes, including unpleasant reception (subthemes of limited resources, lack of knowledge, and unpreparedness to deal with the crisis), full involvement and various conflicts (subthemes of extreme fatigue, affected family life, uncontrollable fear, and career change), mental or psychological tortures (subthemes of unexpected incidents, distressing observations, and performance dissatisfaction), and patients’ emotional deprivation (subthemes of disappointment and frustration, communication disorder, and isolation). Conclusion: This study described the experiences of nurses working in COVID-19 wards facing four emotional challenges. It is suggested to provide psychological support for nurses, meet their needs, and boost their morale as effective measures to expand the quality of care and society’s satisfaction with healthcare services.
{"title":"Shifts in COVID-19 Wards and Emotional Challenges for Nurses: A Qualitative Study","authors":"Z. Khademi, Elham Imani, Manigeh Sayadi Manghalati","doi":"10.34172/hmj.2023.947","DOIUrl":"https://doi.org/10.34172/hmj.2023.947","url":null,"abstract":"Background: In the context of the coronavirus disease 2019 (COVID-19) pandemic, frontline nurses were active in this event and faced numerous challenges. This study aimed to discover the emotional challenges nurses faced on shifts in COVID-19 wards. Methods: In this phenomenological qualitative research, purposive sampling was used to collect the data. A phone interview was conducted with nurses who worked in COVID-19 wards in five Medical Science Universities in Iran in 2020. Then, the recorded interviews were written down. Findings were analyzed using a 6-step thematic analysis guided by Van Manen’s hermeneutic phenomenological approach. The validity and reliability of the study were assessed based on the four criteria proposed by Lincoln and Guba: credibility, dependability, confirmability, and transformability of data. Results: According to analyzed data obtained from interviews with 15 nurses working in the COVID-19 ward, the age average of participants was about 32±5.05. The thematic analysis consisted of four themes, including unpleasant reception (subthemes of limited resources, lack of knowledge, and unpreparedness to deal with the crisis), full involvement and various conflicts (subthemes of extreme fatigue, affected family life, uncontrollable fear, and career change), mental or psychological tortures (subthemes of unexpected incidents, distressing observations, and performance dissatisfaction), and patients’ emotional deprivation (subthemes of disappointment and frustration, communication disorder, and isolation). Conclusion: This study described the experiences of nurses working in COVID-19 wards facing four emotional challenges. It is suggested to provide psychological support for nurses, meet their needs, and boost their morale as effective measures to expand the quality of care and society’s satisfaction with healthcare services.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132134636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akhtar Sayadi, Z. Hosseini, Ali Mouseli, Saeideh Shahsavari, Somayeh Hoseinvandtabar
Background: Hypertension during pregnancy, along with proteinuria and organ dysfunction, causes preeclampsia, which can lead to several complications, even death in some cases for both the mother and her fetus. This study aimed to compare the risk factors of preeclampsia incidence in multipara women in Bandar Abbas. Methods: This case-control study reviewed 215 medical records of pregnant women referring to the Persian Gulf Hospital of Bandar Abbas, Iran from April 2019 to March 2020. They reviewed the records after their classification into the case (with preeclampsia) and control (without preeclampsia) groups. Both groups were matched, and after gathering the main variables and demographic factors, the data were analyzed by SPSS, version 22. Results: The mean age of the participants was 31.43 ± 5.04 years. There was a significant relationship between preeclampsia and chronic blood pressure (BP) (P=0.0001) with an odds ratio of 14.77. However, no significant association was found between liver disease (P=1.00), heart disease (P=0.095), diabetes (P=0.053), and kidney disease (P=0.76) with preeclampsia. In addition, the comparison results revealed a significant relationship between demographic variables and preeclampsia, systolic blood pressure (SBP) (P=0.001), and diastolic blood pressure (DBP) (P=0.001) with the incidence of preeclampsia. Conclusion: The results showed that even though there was no significant relationship between diabetes, heart disease, and kidney disease with preeclampsia, patients with these diseases were 2.27, 1.21, and 6.3 times more likely to develop preeclampsia, respectively.
{"title":"Risk Factors Associated With the Occurrence of Preeclampsia in Southern Iran","authors":"Akhtar Sayadi, Z. Hosseini, Ali Mouseli, Saeideh Shahsavari, Somayeh Hoseinvandtabar","doi":"10.34172/hmj.2023.945","DOIUrl":"https://doi.org/10.34172/hmj.2023.945","url":null,"abstract":"Background: Hypertension during pregnancy, along with proteinuria and organ dysfunction, causes preeclampsia, which can lead to several complications, even death in some cases for both the mother and her fetus. This study aimed to compare the risk factors of preeclampsia incidence in multipara women in Bandar Abbas. Methods: This case-control study reviewed 215 medical records of pregnant women referring to the Persian Gulf Hospital of Bandar Abbas, Iran from April 2019 to March 2020. They reviewed the records after their classification into the case (with preeclampsia) and control (without preeclampsia) groups. Both groups were matched, and after gathering the main variables and demographic factors, the data were analyzed by SPSS, version 22. Results: The mean age of the participants was 31.43 ± 5.04 years. There was a significant relationship between preeclampsia and chronic blood pressure (BP) (P=0.0001) with an odds ratio of 14.77. However, no significant association was found between liver disease (P=1.00), heart disease (P=0.095), diabetes (P=0.053), and kidney disease (P=0.76) with preeclampsia. In addition, the comparison results revealed a significant relationship between demographic variables and preeclampsia, systolic blood pressure (SBP) (P=0.001), and diastolic blood pressure (DBP) (P=0.001) with the incidence of preeclampsia. Conclusion: The results showed that even though there was no significant relationship between diabetes, heart disease, and kidney disease with preeclampsia, patients with these diseases were 2.27, 1.21, and 6.3 times more likely to develop preeclampsia, respectively.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124330759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: There is evidence that chronic neuroinflammation is involved in the pathogenesis of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. In this regard, animal models are considered important tools for the study of neuroinflammation associated with these diseases. The injection of lipopolysaccharide (LPS) is the most commonly used approach for inducing neuroinflammation in animal models. However, there are limited and inconsistent studies regarding the effect of the chronic administration of LPS on behavioral parameters. Accordingly, this experimental study aimed to compare the effect of the chronic injection of LPS in two different doses on behavioral alterations, including spatial learning and working memory in mice. Methods: Thirty-six male BALB/c mice were used in this study. After acclimatization for a week, mice were randomly divided into three groups. Control mice were intraperitoneally (IP) injected with saline for seven consecutive days, and mice of the second group received 250 μg/kg LPS (IP) dissolved in saline for a week. Finally, mice of the third group were administered 750 μg/kg LPS (IP) dissolved in saline for a week. Morris water maze (MWM) and Y-maze were performed to assess spatial learning and working memory alterations in treated mice, respectively. Results: It was found that LPS treatment with a high dose (750 μg/kg) results in working memory impairment (P=0.0024) and cognitive dysfunction (P=0.0030) based on Y-maze and MWM test results. Conclusion: Our findings suggest that the LPS-induced model of chronic neuroinflammation can be used as an important tool for the investigation of the pathomechanisms of neurodegenerative disorders and the development of new pharmacotherapeutic options.
{"title":"Chronic Neuroinflammation Induced by Systemic Administration of Lipopolysaccharide Leads to Behavioral Impairments in Mice","authors":"M. Ghasemi-Kasman, Nahid Davoodian","doi":"10.34172/hmj.2023.938","DOIUrl":"https://doi.org/10.34172/hmj.2023.938","url":null,"abstract":"Background: There is evidence that chronic neuroinflammation is involved in the pathogenesis of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. In this regard, animal models are considered important tools for the study of neuroinflammation associated with these diseases. The injection of lipopolysaccharide (LPS) is the most commonly used approach for inducing neuroinflammation in animal models. However, there are limited and inconsistent studies regarding the effect of the chronic administration of LPS on behavioral parameters. Accordingly, this experimental study aimed to compare the effect of the chronic injection of LPS in two different doses on behavioral alterations, including spatial learning and working memory in mice. Methods: Thirty-six male BALB/c mice were used in this study. After acclimatization for a week, mice were randomly divided into three groups. Control mice were intraperitoneally (IP) injected with saline for seven consecutive days, and mice of the second group received 250 μg/kg LPS (IP) dissolved in saline for a week. Finally, mice of the third group were administered 750 μg/kg LPS (IP) dissolved in saline for a week. Morris water maze (MWM) and Y-maze were performed to assess spatial learning and working memory alterations in treated mice, respectively. Results: It was found that LPS treatment with a high dose (750 μg/kg) results in working memory impairment (P=0.0024) and cognitive dysfunction (P=0.0030) based on Y-maze and MWM test results. Conclusion: Our findings suggest that the LPS-induced model of chronic neuroinflammation can be used as an important tool for the investigation of the pathomechanisms of neurodegenerative disorders and the development of new pharmacotherapeutic options.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123574818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Psoriasis is an autoimmune and common disease that affects 1 to 3% of the world’s population. The appearance and progress of psoriasis are influenced by genetic and environmental factors. Topical steroids have remained the first-line treatment for psoriasis. Long-term use of topical corticosteroids is associated with the risk of side effects. The purpose of this study was to compare the complications and efficacy of topical clobetasol ointment with Salvia officinalis ointment in the treatment of plaque psoriasis. Methods: A topical ointment containing 20% Salvia officinalis was prepared in the pharmaceutical laboratory of Hormozgan University of Medical Sciences. After standardization, this experimental study was performed on 84 voluntary patients with mild plaque psoriasis for two weeks. One group was treated with the prepared S. officinalis ointment twice daily and the other group was treated with topical clobetasol ointment twice daily. In each group, psoriasis severity was assessed using the Psoriasis Area Severity Index (PASI) at determined time points including baseline and one and two weeks after treatment initiation. Results: At the end of treatment (2 weeks), the mean PASI score changed from 2.36 to 1.55 in patients who received topical clobetasol ointment and this score reduced from 2.74 to 2.23 in patients who applied topical S. officinalis ointment. After 14 days of treatment, the mean percentage decrease in mean PASI score was greater in patients who applied topical clobetasol ointment. Conclusion: This study provides evidence that topical clobetasol ointment is more effective than 20% S. officinalis ointment in the treatment of psoriasis. However, S. officinalis ointment can be used as an adjuvant therapy to the main treatments of mild plaque psoriasis.
{"title":"Comparison of the Complications and Efficacy of Topical Clobetasol Ointment with Salvia officinalis Ointment in the Treatment of Plaque Psoriasis","authors":"S. Tavakoli, Amir Hossein Mosalman Haghighi","doi":"10.34172/hmj.2023.8176","DOIUrl":"https://doi.org/10.34172/hmj.2023.8176","url":null,"abstract":"Background: Psoriasis is an autoimmune and common disease that affects 1 to 3% of the world’s population. The appearance and progress of psoriasis are influenced by genetic and environmental factors. Topical steroids have remained the first-line treatment for psoriasis. Long-term use of topical corticosteroids is associated with the risk of side effects. The purpose of this study was to compare the complications and efficacy of topical clobetasol ointment with Salvia officinalis ointment in the treatment of plaque psoriasis. Methods: A topical ointment containing 20% Salvia officinalis was prepared in the pharmaceutical laboratory of Hormozgan University of Medical Sciences. After standardization, this experimental study was performed on 84 voluntary patients with mild plaque psoriasis for two weeks. One group was treated with the prepared S. officinalis ointment twice daily and the other group was treated with topical clobetasol ointment twice daily. In each group, psoriasis severity was assessed using the Psoriasis Area Severity Index (PASI) at determined time points including baseline and one and two weeks after treatment initiation. Results: At the end of treatment (2 weeks), the mean PASI score changed from 2.36 to 1.55 in patients who received topical clobetasol ointment and this score reduced from 2.74 to 2.23 in patients who applied topical S. officinalis ointment. After 14 days of treatment, the mean percentage decrease in mean PASI score was greater in patients who applied topical clobetasol ointment. Conclusion: This study provides evidence that topical clobetasol ointment is more effective than 20% S. officinalis ointment in the treatment of psoriasis. However, S. officinalis ointment can be used as an adjuvant therapy to the main treatments of mild plaque psoriasis.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127328253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Negahi, Ahmad Tamoradi, Behnam Ahmadi, A. Piroozan, Saeed Hosseini Tashnizi
Background: Although diet-induced migraines affect many people, the triggering foodstuffs are not fully identified yet. Detecting migraine-triggering foods and susceptible individuals assist in effective headache management. The aim of this study was to determine the relationship between eating allergens and developing or exacerbating migraine. Methods: This was a descriptive-analytical cross-sectional study with 230 migraine patients referring to the neurology clinic of Shahid Mohammadi hospital in Bandar Abbas. They were selected through purposive sampling. After obtaining informed consent from the patients, the required data were collected and then underwent analysis. Results: Overall, 52.4% and 47.6% of participants were females and males, respectively. Their mean age was 40.57±14.04. Based on the results, 61.9% of participants were married, and 60.3% of them had a family history of migraine. The average number of headaches per month and the duration of each headache were 3.16-4.19 times and 3.76-4.41 hours, respectively. Based on the findings, sausages (55.6%), carbonated beverages (0.54%), peanuts (0.46%), beef (44.4%), and canned food, coffee, and eggs (41.3%) are the most common foodstuffs that cause or exacerbate migraines. On the other hand, chicken (15.9%), strawberry, rice, and wheat (17.5%) had the least impact on the onset and exacerbation of migraine headaches. Conclusion: According to the results, identifying food allergens and eliminating them from patients’ diets can be effective in the prognosis of migraine and individuals’ quality of life.
{"title":"The Relationship Between Food Allergens and Migraine Among Patients With Migraine Referring to Shahid Mohammadi Neurology Clinic","authors":"A. Negahi, Ahmad Tamoradi, Behnam Ahmadi, A. Piroozan, Saeed Hosseini Tashnizi","doi":"10.34172/hmj.2023.8163","DOIUrl":"https://doi.org/10.34172/hmj.2023.8163","url":null,"abstract":"Background: Although diet-induced migraines affect many people, the triggering foodstuffs are not fully identified yet. Detecting migraine-triggering foods and susceptible individuals assist in effective headache management. The aim of this study was to determine the relationship between eating allergens and developing or exacerbating migraine. Methods: This was a descriptive-analytical cross-sectional study with 230 migraine patients referring to the neurology clinic of Shahid Mohammadi hospital in Bandar Abbas. They were selected through purposive sampling. After obtaining informed consent from the patients, the required data were collected and then underwent analysis. Results: Overall, 52.4% and 47.6% of participants were females and males, respectively. Their mean age was 40.57±14.04. Based on the results, 61.9% of participants were married, and 60.3% of them had a family history of migraine. The average number of headaches per month and the duration of each headache were 3.16-4.19 times and 3.76-4.41 hours, respectively. Based on the findings, sausages (55.6%), carbonated beverages (0.54%), peanuts (0.46%), beef (44.4%), and canned food, coffee, and eggs (41.3%) are the most common foodstuffs that cause or exacerbate migraines. On the other hand, chicken (15.9%), strawberry, rice, and wheat (17.5%) had the least impact on the onset and exacerbation of migraine headaches. Conclusion: According to the results, identifying food allergens and eliminating them from patients’ diets can be effective in the prognosis of migraine and individuals’ quality of life.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129262080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shideh Rafati, L. Hassani, M. Tamaddondar, A. Sabili
Background: Hemodialysis is a method for removing excess fluid and uremic waste from the body of chronic renal failure (CRF) patients. It stops death in patients with CRF. Various factors can affect the survival of patients undergoing hemodialysis treatment. The current study aimed to determine some factors affecting hemodialysis patients’ survival using the LASSO-Cox approach. Methods: This cross-sectional study examined 252 patients undergoing hemodialysis from 2010 to 2016 in all hospitals of Bandar Abbas, Iran, whose data had been recorded in the hemodialysis unit, or it was possible to obtain their files. The Cox model under the LASSO variable selection technique (LASSO-Cox) was applied for data analysis. The collected data were analyzed using SPSS 23.0 (IBM) software and glmnet and survival packages in R software, version 3.5.1. Results: Overall, 35 (13.9%) death events were observed in this study. The mean follow-up time of 252 patients was equal to 10.93±7.82 years. Based on the results of the Cox-Lasso method, the risk of mortality for patients with a diploma was 49% lower than that of the illiterate group (HR=0.51; 95% CI: 0.02, 0.57; P=0.021). The risk of death for unemployed patients and farmers was 0.66 (HR=1.66; 95% CI: 1.51, 25.79; P=0.004) and 0.29 (HR=1.29; 95% CI: 1.14, 27.40; P=0.005) higher than that of employees, respectively. Further, by an increase in the frequency of dialysis per week, the risk of death was reduced by 0.34 (HR=0.66; 95% CI: 0.04, 0.82; P=0.022), and one unit increase in the duration of dialysis per hour increased the risk of death by 2.23 times (HR=2.23; 95% CI: 1.41, 27.1; P=0.010). Conclusion: Education level, job, frequency of hemodialysis per week, and duration of hemodialysis per hour were the most important variables in the survival of hemodialysis patients. As a result, it seems that more education for nurses working in hemodialysis wards and the involved patients can be useful to heed the recommendations of physicians in terms of the required duration for hemodialysis per hour and the number of sessions per week.
{"title":"Identification of Effective Factors on the Survival of Hemodialysis Patients Using the LASSO-Cox Approach","authors":"Shideh Rafati, L. Hassani, M. Tamaddondar, A. Sabili","doi":"10.34172/hmj.2023.4115","DOIUrl":"https://doi.org/10.34172/hmj.2023.4115","url":null,"abstract":"Background: Hemodialysis is a method for removing excess fluid and uremic waste from the body of chronic renal failure (CRF) patients. It stops death in patients with CRF. Various factors can affect the survival of patients undergoing hemodialysis treatment. The current study aimed to determine some factors affecting hemodialysis patients’ survival using the LASSO-Cox approach. Methods: This cross-sectional study examined 252 patients undergoing hemodialysis from 2010 to 2016 in all hospitals of Bandar Abbas, Iran, whose data had been recorded in the hemodialysis unit, or it was possible to obtain their files. The Cox model under the LASSO variable selection technique (LASSO-Cox) was applied for data analysis. The collected data were analyzed using SPSS 23.0 (IBM) software and glmnet and survival packages in R software, version 3.5.1. Results: Overall, 35 (13.9%) death events were observed in this study. The mean follow-up time of 252 patients was equal to 10.93±7.82 years. Based on the results of the Cox-Lasso method, the risk of mortality for patients with a diploma was 49% lower than that of the illiterate group (HR=0.51; 95% CI: 0.02, 0.57; P=0.021). The risk of death for unemployed patients and farmers was 0.66 (HR=1.66; 95% CI: 1.51, 25.79; P=0.004) and 0.29 (HR=1.29; 95% CI: 1.14, 27.40; P=0.005) higher than that of employees, respectively. Further, by an increase in the frequency of dialysis per week, the risk of death was reduced by 0.34 (HR=0.66; 95% CI: 0.04, 0.82; P=0.022), and one unit increase in the duration of dialysis per hour increased the risk of death by 2.23 times (HR=2.23; 95% CI: 1.41, 27.1; P=0.010). Conclusion: Education level, job, frequency of hemodialysis per week, and duration of hemodialysis per hour were the most important variables in the survival of hemodialysis patients. As a result, it seems that more education for nurses working in hemodialysis wards and the involved patients can be useful to heed the recommendations of physicians in terms of the required duration for hemodialysis per hour and the number of sessions per week.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127521456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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