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Deleterious Effects of Exposure to 900 MHz Radiofrequency Waves on Brain Trace Elements Improved by Administration of Vitamins 暴露于900兆赫射频波对大脑微量元素的有害影响通过服用维生素得到改善
Pub Date : 2022-03-29 DOI: 10.34172/hmj.2022.06
Mansour Azimzadeh, G. Jelodar
Background: There is an increasing public concern about the harmful effect of exposure to electromagnetic radiation emitted from base transceiver stations (BTS). Objectives: This study was carried out to evaluate the impact of exposure to 900 MHz radiofrequency (RF) on the concentration of brain trace elements (TEs), including zinc (Zn), manganese (Mn), copper (Cu), and iron (Fe), as well as the protective effect of vitamins (C and E) supplementation. Methods: In this study, 30 male rats were assigned into three non-exposed groups, including sham I, II, and III receiving saline, vitamin C, and vitamins C+E, respectively, and three exposed groups, including sham-exposed (saline), test I (vitamin C), and test II (vitamins C+E). The exposed groups were exposed to RF for one month (4 h/day) and the brain TE levels were measured using atomic absorption spectrophotometry. Results: Compared with the non-exposed groups (I, II, and III), a remarkable elevation in the concentration of Mn, Fe, Cu, and Cu/Zn ratio accompanied by a significantly lower level of Zn was noticed in the rats’ brain of the sham-exposed group (P<0.05). However, pretreatment with both vitamins C and C+E improved the evaluated TE imbalances caused by exposure to 900 MHz RF with no significant difference between the two test groups (P>0.05). Conclusion: Disruption of brain TEs homeostasis caused by the exposure to 900 MHz RF improved and normalized by pretreatment with vitamins C and E+C.
背景:公众越来越关注暴露于基站收发器(BTS)发射的电磁辐射的有害影响。目的:本研究旨在评估暴露于900 MHz射频(RF)对脑微量元素(TEs)(包括锌(Zn)、锰(Mn)、铜(Cu)和铁(Fe))浓度的影响,以及补充维生素(C和E)的保护作用。方法:将30只雄性大鼠分为未暴露组(假1、假2、假3)和暴露组(假1、假2、假3),分别给予生理盐水、维生素C和维生素C+E;暴露组(假1、试验1、试验2)。暴露组暴露于射频下1个月(4小时/天),用原子吸收分光光度法测定脑TE水平。结果:与未暴露组(ⅰ、ⅱ、ⅲ)比较,假暴露组大鼠脑内Mn、Fe、Cu浓度和Cu/Zn比值显著升高,Zn水平显著降低(P0.05)。结论:维生素C和E+C预处理可改善和恢复900 MHz射频暴露引起的脑TEs稳态破坏。
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引用次数: 0
The Impact of Intervention Based on Protection Motivation Theory on Treatment Adherence in Patients with Ischemic Heart Disease 基于保护动机理论的干预对缺血性心脏病患者治疗依从性的影响
Pub Date : 2022-03-29 DOI: 10.34172/hmj.2022.07
Masoomeh Zakipoor, Kobra Hajalizadeh, M. Seirafi, Marziyeh Nikparvar, S. Abedini
Background: Patients with ischemic heart disease (IHD) gradually reduce their follow-up treatment due to the vulnerable physical condition and high involvement with the disease-related treatment process. The purpose of this research was to investigate the effect of intervention based on the protection motivation theory (PMT) on treatment adherence in patients with IHD. Methods: This quasi-experimental research used a pretest-posttest design with a control group. The statistical population included all patients with IHD referred to the Payambar Azam hospital in Bandar Abbas, Iran for more than once between March 2019 and May 2020. A total of 16 patients were selected through the matched targeted sampling and randomly assigned into two equal groups of experimental and control (n = 8 each). The test group received an intervention based on the PMT in six 90-minute sessions within 45 days. We used the Modanloo Treatment Adherence Questionnaire (TAQ), and the data were analyzed using the analysis of covariance (ANCOVA) in the SPSS23 statistical software. Results: The results of ANCOVA showed that the intervention based on the PMT significantly increased the treatment adherence and its subscales in patients with IHD (P<0.001). Conclusion: Intervention based on the PMT can be used as an effective intervention to increase treatment adherence in patients with IHD, depending on proper nutrition training, self-care skills, awareness-raising, and relaxation exercises.
背景:缺血性心脏病(IHD)患者由于身体状况脆弱,对疾病相关治疗过程的参与度高,随访治疗逐渐减少。本研究旨在探讨基于保护动机理论(PMT)的干预对IHD患者治疗依从性的影响。方法:准实验研究采用前测后测设计,并设对照组。统计人群包括2019年3月至2020年5月期间不止一次转诊到伊朗阿巴斯港Payambar Azam医院的所有IHD患者。通过匹配的目标抽样,共选择16例患者,随机分为实验组和对照组两组,每组8例。试验组在45天内接受6次90分钟的PMT干预。采用Modanloo治疗依从性问卷(TAQ),在SPSS23统计软件中采用协方差分析(ANCOVA)对数据进行分析。结果:ANCOVA结果显示,基于PMT的干预显著提高了IHD患者的治疗依从性及其亚量表(P<0.001)。结论:基于PMT的干预可以作为一种有效的干预措施来提高IHD患者的治疗依从性,这取决于适当的营养训练、自我保健技能、意识提高和放松练习。
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引用次数: 1
The Psychological Impact of Coronavirus Disease 2019 Pandemic in the Iranian Population: A Cross-sectional Study 2019冠状病毒病大流行对伊朗人群的心理影响:一项横断面研究
Pub Date : 2022-03-29 DOI: 10.34172/hmj.2022.04
Mohammad Reza Golzarfeshalami, M. Mahmoodi, Nasrin Davari Dolatabadi
Background: Coronavirus disease 2019 (COVID-19) outbreak was first detected in China in 2019 and it has become a global threat affecting many countries. This study aimed to investigate the psychological impacts of COVID-19 pandemic, including anxiety, depression, and stress in the Iranian population. Methods: In this cross-sectional study, an online survey was designed using the simple random sampling technique. A total of 1091 online surveys were completed during 10-18 May, 2020. The collected data included demographics, physical symptoms, history of COVID-19, information and attitudes toward COVID-19, as well as precautions and protection measures against the disease. Psychological impacts were evaluated using the Impact of Event Scale–Revised (IES-R), and mental health status by the Depression, Anxiety, and Stress Scale (DASS-21). Linear regression was used to analyze the associations. Results: According to the results, 47.7% of the respondents demonstrated moderate to severe psychological impacts caused by the COVID-19 pandemic, of whom 28.3%, 24%, and 22.3% suffered from moderate to severe depression, anxiety, and stress symptoms, respectively. Also, female gender, decrease or cessation of income, and having chronic diseases were associated with more psychological impacts and higher scores of DASS-21 subscales. Conclusion: Approximately, a quarter of the participants reported moderate to high levels of stress, anxiety, and depression, and half of the participants indicated moderate to severe psychological impacts. In this study, we successfully identified the vulnerable individuals to determine appropriate interventions and control the psychological consequences.
背景:2019冠状病毒病(COVID-19)疫情于2019年在中国首次发现,已成为影响许多国家的全球性威胁。本研究旨在调查COVID-19大流行对伊朗人口的心理影响,包括焦虑、抑郁和压力。方法:本研究采用简单随机抽样的方法,设计了一项在线调查。2020年5月10日至18日期间,共完成了1091份在线调查。收集的数据包括人口统计学、身体症状、新冠肺炎病史、对新冠肺炎的信息和态度、预防措施和保护措施。使用事件影响量表(IES-R)评估心理影响,使用抑郁、焦虑和压力量表(DASS-21)评估心理健康状况。采用线性回归分析相关性。结果:47.7%的受访者表现出中至重度的新冠肺炎大流行心理影响,其中28.3%、24%和22.3%的受访者表现出中至重度的抑郁、焦虑和压力症状。此外,女性、收入减少或停止以及患有慢性疾病与更大的心理影响和更高的DASS-21分量表得分有关。结论:大约四分之一的参与者报告了中度到高度的压力、焦虑和抑郁,一半的参与者表现出中度到严重的心理影响。在本研究中,我们成功地识别了弱势个体,以确定适当的干预措施和控制心理后果。
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引用次数: 0
Antioxidant Effect of Swimming Training and Royal Jelly Consumption in the Hippocampus Tissue of Rats With Alzheimer’s Disease 游泳训练和蜂王浆对阿尔茨海默病大鼠海马组织的抗氧化作用
Pub Date : 2022-03-29 DOI: 10.34172/hmj.2022.11
Awat Hasanloei, Khalid Mohamadzadeh Salamat, S. Hosseini
Background: As an age-related disease, Alzheimer’s disease (AD) is characterized by memory loss and cognitive impairment. Although oxidative stress factors increase in AD, exercise and nutrition can have protective and antioxidant effects. This study aimed to explore the antioxidant effects of swimming training (ST) and royal jelly (RJ) consumption in the hippocampus tissue of rats with AD. Methods: In this experimental study, 20 rats with AD were selected and divided into four groups, including control, ST, RJ, and ST+RJ. In order to probe the effects of AD induction on superoxide dismutase (SOD) and glutathione peroxidase (GPx), five healthy rats were assigned into the healthy control group. For eight weeks, the ST groups performed ST three times per week (5 minutes in the first week to 60 minutes in the last week), and the RJ groups received 100 mg/kg RJ per day. The Shapiro-Wilk, independent samples t test, and two-way analysis of variance (ANOVA) tests were used to analyze the findings (P≤0.05). Results: AD induction had a significant effect on increasing SOD (P=0.04) and decreasing GPx (P=0.001). Also, ST (P=0.001) and RJ (P=0.01) had a significant effect on increasing GPx; ST (P=0.001) and RJ (P=0.001) had a significant effect on decreasing SOD. Furthermore, ST with RJ had an interactive effect on increasing GPx (P=0.03) and decreasing SOD (P=0.001). Conclusion: In general, ST and RJ appear to simultaneously improve the gene expression of antioxidants in the hippocampus tissue of AD rats. In addition, the antioxidant effects of ST were more favorable than those of RJ. It appears that different doses of RJ should also be considered.
背景:作为一种与年龄相关的疾病,阿尔茨海默病(AD)以记忆丧失和认知障碍为特征。虽然氧化应激因子在AD中增加,但运动和营养可以起到保护和抗氧化作用。本研究旨在探讨游泳训练(ST)和蜂王浆(RJ)消耗对AD大鼠海马组织的抗氧化作用。方法:本实验选取20只AD大鼠,将其分为对照组、ST组、RJ组、ST+RJ组。为探讨AD诱导对超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPx)的影响,选择5只健康大鼠作为健康对照组。连续8周,ST组每周进行3次ST(第一周5分钟至最后一周60分钟),RJ组每天接受100 mg/kg RJ。采用Shapiro-Wilk检验、独立样本t检验和双因素方差分析(ANOVA)检验对结果进行分析(P≤0.05)。结果:AD诱导大鼠血清SOD升高(P=0.04), GPx降低(P=0.001)。此外,ST (P=0.001)和RJ (P=0.01)对GPx的增加有显著影响;ST (P=0.001)和RJ (P=0.001)对降低SOD有显著作用。此外,ST与RJ对GPx升高(P=0.03)和SOD降低(P=0.001)有交互作用。结论:总的来说,ST和RJ似乎可以同时改善AD大鼠海马组织中抗氧化剂的基因表达。此外,ST的抗氧化作用优于RJ。似乎还应该考虑不同剂量的RJ。
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引用次数: 1
Effect of Endurance Training and High-Fat Diet on Serum Interleukin-6 and 17 Levels in Male Wistar Rats 耐力训练和高脂饮食对雄性Wistar大鼠血清白细胞介素-6和17水平的影响
Pub Date : 2022-03-29 DOI: 10.34172/hmj.2022.03
Peyman Nayebpoor, J. Bashiri, F. Gholami
Background: High-fat diet (HFD) can cause several health problems and chronic inflammation. The aim of the study was to examine the effect of endurance training along with HFD on serum levels of interleukin-6 (IL-6) and IL-17 in male Wistar rats. Methods: In an experimental-controlled study, 36 male Wistar rats were randomly assigned to four groups of HFD, training (T), HFD + training (HFDT), and control (C). Exercise training consisted of 40 minutes of running on treadmill at the maximum speed of 55%-65%, five sessions per week for four weeks. Forty-eight hours following the last intervention, serum IL-6 and IL-17 levels were measured. Data analysis was conducted by one-way analysis of variance (ANOVA) and Tukey’s post hoc test at P<0.05. Results: The results showed that serum IL-6 and IL-17 levels significantly increased as a result of HFD (P=0.001). Endurance training decreased IL-6 and IL-17 levels and there was a significant difference between training and HFD groups (P=0.001). However, based on the difference between HFDT and control groups, the variables did not return to baseline values. Conclusion: According to the results, HFD induced inflammation in a short duration of four weeks manifested by elevated inflammatory indices. In contrast, endurance training ameliorated HFD-induced elevation of IL-6 and IL-17 and these levels did not return to baseline values.
背景:高脂肪饮食(HFD)会导致多种健康问题和慢性炎症。本研究的目的是研究耐力训练和HFD对雄性Wistar大鼠血清白细胞介素-6 (IL-6)和IL-17水平的影响。方法:在实验对照研究中,36只雄性Wistar大鼠随机分为四组:HFD组、训练组(T)、HFD +训练组(HFDT)和对照组(C)。运动训练包括在跑步机上以55%-65%的最高速度跑步40分钟,每周5次,持续4周。最后一次干预48小时后,测定血清IL-6和IL-17水平。数据分析采用单因素方差分析(ANOVA)和Tukey事后检验,P<0.05。结果:HFD组血清IL-6、IL-17水平显著升高(P=0.001)。耐力训练降低了IL-6和IL-17水平,训练组和HFD组之间差异有统计学意义(P=0.001)。然而,基于HFDT和对照组之间的差异,变量没有返回到基线值。结论:结果显示,HFD在短时间4周内诱导炎症,表现为炎症指标升高。相比之下,耐力训练改善了hfd引起的IL-6和IL-17的升高,这些水平没有回到基线值。
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引用次数: 0
Management of Patients With Drug Packet Ingestion (Body Packers): A Narrative Review 药物包摄入(Body Packers)患者的管理:叙述性回顾
Pub Date : 2022-01-01 DOI: 10.34172/hmj.2022.28
Mehrdad Sayadinia, Bahram Nateghi, Mahan Sayadinia
Context: Due to the increased freight traffic and illicit movement of drug packages disguised inside the body, as well as the shortage of adequate surgical textbook references regarding the management, we aimed to utilize our clinical experience and collect relevant content to present a plausible solution. Evidence Acquisition: The PubMed, Scopus, Web of Sciences, and Google Scholar databases were systematically searched for related articles. Results: Of the overall 294 retrieved articles, 37 articles remained for review after the exclusion of duplicates and unrelated papers. Imaging is beneficial in several cases of body packing. Abdominopelvic computed tomography without contrast, which is likely the best diagnostic tool for identifying the existence and quantity of packets in these patents, can help doctors avoid common diagnostic mistakes. Whether it be opioids, cocaine, or amphetamines, each drug class should have a customized course of action. Conclusion: Although conservative treatment is often employed for these individuals, early surgical intervention for packet removal is advised in the cases of ingesting cocaine and amphetamine packets due to the lack of an appropriate antagonist.
背景:由于药物包装伪装在体内的货运量增加和非法流动,以及缺乏足够的外科教科书参考管理,我们旨在利用我们的临床经验,收集相关内容,提出一个合理的解决方案。证据获取:系统地检索PubMed、Scopus、Web of Sciences和Google Scholar数据库查找相关文章。结果:在总共294篇被检索的文献中,排除重复和不相关的文献后,有37篇文献被保留。在某些情况下,成像是有益的。不加对比的腹部骨盆计算机断层扫描,可能是最好的诊断工具,可以识别这些专利中包的存在和数量,可以帮助医生避免常见的诊断错误。无论是阿片类药物、可卡因还是安非他明,每一类药物都应该有一个定制的作用过程。结论:尽管保守治疗通常用于这些个体,但由于缺乏适当的拮抗剂,建议在摄入可卡因和安非他明包的情况下,早期手术干预去除包。
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引用次数: 0
The Efficacy of Mindfulness-based Stress Reduction on Health Control and Self-care in Women With Hypertension: A Randomized-controlled Trial 正念减压对高血压妇女健康控制和自我护理的疗效:一项随机对照试验
Pub Date : 2022-01-01 DOI: 10.34172/hmj.2022.26
M. Ashrafi, F. Jomehri, M. Niknam, Amin Rafieipour
Background: It is necessary to help people with hypertension solve the related problems by identifying factors affecting their health control and self-care, which can be improved using different approaches. This study aimed to determine the effectiveness of mindfulness-based stress reduction (MBSR) therapy in improving health control and self-care in women with hypertension. Methods: The statistical population of this randomized controlled trial study included all women with hypertension referred to the Farshchian Specialized Cardiovascular Clinic (Hamadan, Iran) in 2019. The sample size consisted of 30 subjects who were selected by the convenience sampling method and randomly assigned to two experimental and control groups each containing 15 subjects. The MBSR group was trained in eight 90-minute sessions, while the control group received no intervention. Data were analyzed using repeated-measure analysis of variance by SPSS 22. Results: The results revealed that MBSR significantly affected health control (P<0.001) and self-care (P<0.001) in women with hypertension. Conclusion: Overall, MBSR could effectively improve health control and self-care in women with hypertension, thus it may be used for decreasing psychological problems in this group of women.
背景:有必要通过识别影响高血压患者健康控制和自我保健的因素,帮助高血压患者解决相关问题,并通过不同的途径加以改善。本研究旨在确定正念减压(MBSR)疗法在改善高血压女性健康控制和自我保健方面的有效性。方法:本随机对照试验研究的统计人群包括2019年到伊朗哈马丹Farshchian心血管专科诊所就诊的所有高血压女性。样本量为30例,采用方便抽样法随机分为实验组和对照组各15例。正念减压组接受了8次90分钟的训练,而对照组则没有接受任何干预。数据分析采用SPSS 22重复测量方差分析。结果:正念减压对高血压妇女的健康控制(P<0.001)和自我保健(P<0.001)有显著影响。结论:总体而言,正念减压疗法能有效改善高血压妇女的健康控制和自我保健,可用于减少高血压妇女的心理问题。
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引用次数: 0
COVID-19 Inpatients in Sothern Iran: A Time Series Forecasting for 2020-2021 伊朗南部COVID-19住院患者:2020-2021年的时间序列预测
Pub Date : 2021-12-29 DOI: 10.34172/hmj.2021.21
Maryam Soleimani Movahed, F. Khorrami, A. Sheikhtaheri, Mehdi Hasaniazad, Abdollah Gharibzadeh, M. Kamali, Nader Alishan Karami
Background: The rapid spread of coronavirus disease 2019 (COVID-19) turned into a global pandemic and has already plunged health systems all over the world into an unprecedented crisis. The start of the third wave in the fall of 2020 is likely to trigger a higher prevalence in the upcoming months. This article analyzed the inpatients’ time series data in Hormozgan province to forecast the trend of COVID-19 inpatients using time series modelling. Methods: To forecast COVID-19 inpatients in Hormozgan province (Iran), this time series study included data related to the daily new cases of 1) confirmed inpatients, 2) suspected inpatients, 3) deaths, 4) alive discharged patients, 5) admitted cases to intensive care units (ICUs), 6) ICU discharged cases, and 7) ICU inpatient service day were collected from 22 hospitals in the province from 20 February to 13 November 2020. Autoregressive integrated moving average (ARIMAX) and Prophet methods were applied for forecasting the trend of inpatient indicators to the end of the Iranian official calendar year. We used the Python programming language for data analysis. Results: Based on the findings of this study which proved the outperformance of Prophet to ARIMAX, it can be concluded that time series of suspected inpatients, confirmed inpatients, recovered cases, deaths, and ICU-inpatient service day followed a downward trend while ICU-admission and discharge time series are likely taking an upward trend in Hormozgan to the end of the current Iranian calendar year. Conclusion: Prophet outperformed ARIMAX for inpatient forecasting. By forecasting and taking appropriate prevention, diagnostic and treatment, educational, and supportive measures, healthcare policy makers could be able to control COVID-19 inpatient indicators.
背景:2019冠状病毒病(COVID-19)的迅速传播已演变为全球大流行,并已使世界各地的卫生系统陷入前所未有的危机。2020年秋季第三波疫情的开始可能会在未来几个月引发更高的流行率。本文对霍尔木兹甘省住院患者时间序列数据进行分析,采用时间序列模型预测新冠肺炎住院患者趋势。方法:为预测伊朗霍尔木兹甘省2019冠状病毒病住院病例,本时间序列研究收集该省22家医院2020年2月20日至11月13日每日新增确诊住院病例1)、疑似住院病例2)、死亡病例3)、活出院病例4)、重症监护病房(ICU)住院病例5)、ICU出院病例6)和ICU住院服务日相关数据。采用自回归综合移动平均(ARIMAX)和Prophet方法预测伊朗官方日历年结束时住院指标的趋势。我们使用Python编程语言进行数据分析。结果:本研究结果证明Prophet优于ARIMAX,因此可以得出结论,霍尔木兹甘地区到当前伊朗日历年底,疑似住院患者、确诊住院患者、康复病例、死亡病例和icu住院天数时间序列呈下降趋势,而icu入院和出院时间序列可能呈上升趋势。结论:Prophet在住院患者预测方面优于ARIMAX。通过预测和采取适当的预防、诊断和治疗、教育和支持措施,卫生保健政策制定者可以控制COVID-19住院指标。
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引用次数: 0
Assessment of Parental Performance of Children with Chronic Kidney Disease in Ahvaz 阿瓦士地区慢性肾病患儿家长表现评估
Pub Date : 2021-12-29 DOI: 10.34172/hmj.2021.24
Zainab Eydivandi, Fatemeh Jafari Naleshkenani, Rahim Pendar
Background: Children with chronic kidney disease (CKD) experience many complications such as anemia, growth failure, stress and emotional problems. The responsibility for providing these children with proper health care is their family. The way parents of a child with CKD act is very important in the care of their child. We aimed to evaluate the level of performance of parents with children with CKD in Ahvaz. Method: In this descriptive cross-sectional study, census method was used for sampling. After completing the demographic questionnaires, the Family Assessment Device questionnaire (in general performance dimensions, communication, problem solving, role, emotional responsiveness, emotional involvement, behavior control) was used to assess parental performance of these children. Results: The study involved 42 parents of children with CKD. The mean±SD age of the children was 9.85±1.22 and the mean±SD duration of illness was 11.18±9.38 months. The results showed that the scores related to general performance (P=0.001), performance communication (P=0.001), problem-solving function (P=0.024), performance role (P=0.038), emotional performance response (P=0.001), emotional performance involvement (P=0.001), performance behavior control (P=0.001) of the study population was significantly higher than the permissible value set by the questionnaire providers, indicating worse performance. Conclusion: The results showed that parents of children with CKD did not have a sufficient level of performance in caring for their children. Therefore, it seems necessary to provide training programs for this group.
背景:慢性肾脏疾病(CKD)的儿童会经历许多并发症,如贫血、生长衰竭、压力和情绪问题。向这些儿童提供适当保健的责任在于他们的家庭。CKD患儿的父母的行为方式对照顾他们的孩子非常重要。我们的目的是评估阿瓦士CKD患儿家长的表现水平。方法:采用描述性横断面研究,采用人口普查方法进行抽样。在完成人口统计问卷后,采用家庭评估装置问卷(一般表现维度、沟通、问题解决、角色、情绪反应、情绪投入、行为控制)对这些儿童的父母表现进行评估。结果:本研究涉及42名CKD患儿家长。患儿平均±SD年龄为9.85±1.22岁,平均±SD病程为11.18±9.38个月。结果显示,研究人群在一般绩效(P=0.001)、绩效沟通(P=0.001)、问题解决功能(P=0.024)、绩效角色(P=0.038)、情绪绩效反应(P=0.001)、情绪绩效投入(P=0.001)、绩效行为控制(P=0.001)等方面的得分均显著高于问卷提供者设定的允许值,表现较差。结论:结果显示CKD患儿家长在照顾孩子方面表现不佳。因此,似乎有必要为这一群体提供培训计划。
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引用次数: 0
Aerobic Training Improves Symptoms of Neuropathy and Quality of Life in Patients with Diabetic Peripheral Neuropathy 有氧训练改善糖尿病周围神经病变患者的神经病变症状和生活质量
Pub Date : 2021-12-29 DOI: 10.34172/hmj.2021.23
F. Gholami
Background: Painful symptoms of diabetic peripheral neuropathy (DPN) is common in patients with type 2 diabetes mellitus (T2DM), which can reduce the quality of life. The effect of aerobic training on neuropathic symptoms and quality of life in people with type 2 diabetes with peripheral neuropathy was investigated in the present study. Methods: Twenty-four patients with DPN participated in this randomized controlled study. Participants were randomly assigned to the experimental or control groups. The experimental group underwent exercise training consisting of 20-45 minutes aerobic training on the treadmill at 50%-70% of heart rate reserve over three months. Before and after the experimental period, blood samples were taken in a fasting state, and Michigan Diabetic Neuropathy Score (MDNS), monofilament test and quality of life (QOL), and sleep quality (SQ) questionnaires were completed. Data analysis was performed using repeated-measures ANOVA. Results: In the experimental group MDNS score significantly improved compared with the control condition (P<0.05). There was a significant difference between groups regarding 10 g monofilament test score (P<0.05). Moreover, QOL and SQ significantly improved in the experimental group with a significant inter-group difference (P<0.05). Hemoglobin A1c (HbA1c) level decreased by 7.4% in the experimental group, which was statistically different from the control group (P<0.05). Pearson’s correlation indicated a significant correlation between HbA1c level and monofilament score. Conclusion: Regular aerobic training over a short period potentially improves symptoms of DPN and QOL. Lowered levels of HbA1c were correlated with improved foot sensation.
背景:糖尿病周围神经病变(DPN)疼痛症状在2型糖尿病(T2DM)患者中很常见,可降低生活质量。本研究探讨了有氧训练对伴有周围神经病变的2型糖尿病患者的神经病变症状和生活质量的影响。方法:对24例DPN患者进行随机对照研究。参与者被随机分为实验组和对照组。实验组在三个月内以50%-70%的心率储备在跑步机上进行20-45分钟的有氧训练。实验前后空腹采血,完成密歇根糖尿病神经病变评分(MDNS)、单丝测试及生活质量(QOL)、睡眠质量(SQ)问卷。数据分析采用重复测量方差分析。结果:实验组患者MDNS评分较对照组显著提高(P<0.05)。10 g单丝试验评分组间差异有统计学意义(P<0.05)。实验组患者的生活质量和SQ均显著改善,组间差异有统计学意义(P<0.05)。实验组患者糖化血红蛋白(HbA1c)水平降低7.4%,与对照组比较差异有统计学意义(P<0.05)。Pearson相关提示HbA1c水平与单丝评分有显著相关性。结论:短期有规律的有氧训练可能改善DPN的症状和生活质量。HbA1c水平降低与足部感觉改善相关。
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引用次数: 0
期刊
Hormozgan Medical Journal
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