Background: Clinical studies have indicated that exercise activity and supplementation may have different effects on the immune system and health. The present study aimed to determine the effect of sesame and interval training on heat shock protein 70 (HSP70) gene expression and light chain 3-I (LC3-I) proteins among inactive, middle-aged men. Methods: In this randomized clinical trial and quasi-experimental study which was conducted in fall, 2019, 60 middle-aged inactive men who had the habit of going to the parks in Karaj, Iran were selected as the study’s statistical subject and, then, were randomly divided into four groups (i.e., sesame supplement, interval training, sesame supplement+interval training, control). Sesame, and sesame supplement+interval training groups received sesame. The training protocol lasted for 12 weeks. HSP70 gene expression and LC3-I were measured before and after study using the enzymatic method. As for the homogeneity of variances, the Levene’s test and the Shapiro–Wilk test were used to investigate the natural distribution. Analysis of variance was used to investigate differences in four groups. Results: Significant differences were found regarding LC3-I (P<0.001) and HSP70 (P<0.001). According to the results of the Tukey post hoc test, there was a significant difference between the training+sesame group and controls (P≤0.05). Conclusion: It was concluded that high interval intensity training with sesame reduced HSP70 gene expression and LC3-I. The novelty of this study lay in the fact that it found consuming supplementation and training capable of synergistically reducing chaperone protein and autophagy indicator.
{"title":"Randomized Clinical Trial Effect of Sesame and Training on Heat Shock Protein 70 Gene Expression and Light Chain 3-I Proteins of Inactive Middle-Aged Men","authors":"F. Nameni","doi":"10.34172/hmj.2022.17","DOIUrl":"https://doi.org/10.34172/hmj.2022.17","url":null,"abstract":"Background: Clinical studies have indicated that exercise activity and supplementation may have different effects on the immune system and health. The present study aimed to determine the effect of sesame and interval training on heat shock protein 70 (HSP70) gene expression and light chain 3-I (LC3-I) proteins among inactive, middle-aged men. Methods: In this randomized clinical trial and quasi-experimental study which was conducted in fall, 2019, 60 middle-aged inactive men who had the habit of going to the parks in Karaj, Iran were selected as the study’s statistical subject and, then, were randomly divided into four groups (i.e., sesame supplement, interval training, sesame supplement+interval training, control). Sesame, and sesame supplement+interval training groups received sesame. The training protocol lasted for 12 weeks. HSP70 gene expression and LC3-I were measured before and after study using the enzymatic method. As for the homogeneity of variances, the Levene’s test and the Shapiro–Wilk test were used to investigate the natural distribution. Analysis of variance was used to investigate differences in four groups. Results: Significant differences were found regarding LC3-I (P<0.001) and HSP70 (P<0.001). According to the results of the Tukey post hoc test, there was a significant difference between the training+sesame group and controls (P≤0.05). Conclusion: It was concluded that high interval intensity training with sesame reduced HSP70 gene expression and LC3-I. The novelty of this study lay in the fact that it found consuming supplementation and training capable of synergistically reducing chaperone protein and autophagy indicator.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132179531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Azadeh Amirimoghadam Shirvan, M. Nikoogoftar, H. Ahadi
Background: Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal diseases that affects a significant part of the community. This study aimed to evaluate the effectiveness of schema therapy on the somatic symptom experience, medication adherence, and perceived stress in patients with IBS. Methods: The research method was a quasi-experimental research with pre-test, post-test, and follow-up and a control group. The statistical population of this study consisted of all patients with IBS who referred to medical centers and neurologists between November and January 2017. The study sample included 30 patients with IBS who were randomly divided into equal schema therapy and control groups. The intervention lasted two months. Perceived Stress Scale (PSS-14), Somatic Symptom Experience Questionnaire (BSS-FS), and Medication Adherence Questionnaire (MMAS-8) were used to collect data. In this study, means and standard deviations and analysis of variance with repeated measures were employed for descriptive statistics and the inferential analysis of results, respectively, using SPSS, version 22. Results: The results showed that schema therapy was effective on somatic symptom experience (P < 0.001), medication adherence (P < 0.001), and perceived stress (P < 0.001) in patients with IBS. Conclusion: It can be concluded that schema therapy was effective on somatic symptom experience, medication adherence, and perceived stress in patients with IBS; thus, it can be used to reduce psychological problems in patients with IBS.
{"title":"The Effectiveness of Schema Therapy Intervention on Somatic Symptom Experience, Medication Adherence, and Perceived Stress in Patients With Irritable Bowel Syndrome","authors":"Azadeh Amirimoghadam Shirvan, M. Nikoogoftar, H. Ahadi","doi":"10.34172/hmj.2022.18","DOIUrl":"https://doi.org/10.34172/hmj.2022.18","url":null,"abstract":"Background: Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal diseases that affects a significant part of the community. This study aimed to evaluate the effectiveness of schema therapy on the somatic symptom experience, medication adherence, and perceived stress in patients with IBS. Methods: The research method was a quasi-experimental research with pre-test, post-test, and follow-up and a control group. The statistical population of this study consisted of all patients with IBS who referred to medical centers and neurologists between November and January 2017. The study sample included 30 patients with IBS who were randomly divided into equal schema therapy and control groups. The intervention lasted two months. Perceived Stress Scale (PSS-14), Somatic Symptom Experience Questionnaire (BSS-FS), and Medication Adherence Questionnaire (MMAS-8) were used to collect data. In this study, means and standard deviations and analysis of variance with repeated measures were employed for descriptive statistics and the inferential analysis of results, respectively, using SPSS, version 22. Results: The results showed that schema therapy was effective on somatic symptom experience (P < 0.001), medication adherence (P < 0.001), and perceived stress (P < 0.001) in patients with IBS. Conclusion: It can be concluded that schema therapy was effective on somatic symptom experience, medication adherence, and perceived stress in patients with IBS; thus, it can be used to reduce psychological problems in patients with IBS.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117248887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Afshin Bahadori, Maryam Kalhornia Golkar, Sara Pashang
Background: Helping people with obesity as well as identifying the factors affecting their weight, body image, and self-esteem have become health necessities. Schema therapy is an effective method of third-wave psychotherapy for reducing the problems of obese people. This study aimed to determine the effectiveness of schema therapy in watching body weight as well as improving body image and self-esteem in patients with obesity. Methods: The present study was a randomized controlled trial. The study’s statistical population included all obese people referring to Mehr Counseling and Psychology Center in Tehran (Iran) in 2019. Out of the given population, 32 individuals were selected by adopting convenience sampling method and, then, were randomly divided into schema therapy (n=16) and control (n=16) groups. Data were obtained using body mass index (BMI), Cooper Smith self-esteem questionnaire, and body image questionnaire. The data were analyzed by using repeated-measures analysis of variance and SPSS 22 software. The significance level of the tests was set at 0.05. Results: The results showed that schema therapy had a significant effect on the weight (P<0.001), body image (P<0.001), and self-esteem (P<0.001) compared to the control group. The results also revealed that BMI and self-esteem were significantly improved by schema therapy training (P<0.001). Conclusion: It was concluded that schema therapy had a positive effect on weight, body image, and selfesteem in people with obesity.
{"title":"The Effectiveness of Schema Therapy Intervention in Weight, Body Image and Self-esteem of Obese People: A Randomized Controlled Trial","authors":"Afshin Bahadori, Maryam Kalhornia Golkar, Sara Pashang","doi":"10.34172/hmj.2022.14","DOIUrl":"https://doi.org/10.34172/hmj.2022.14","url":null,"abstract":"Background: Helping people with obesity as well as identifying the factors affecting their weight, body image, and self-esteem have become health necessities. Schema therapy is an effective method of third-wave psychotherapy for reducing the problems of obese people. This study aimed to determine the effectiveness of schema therapy in watching body weight as well as improving body image and self-esteem in patients with obesity. Methods: The present study was a randomized controlled trial. The study’s statistical population included all obese people referring to Mehr Counseling and Psychology Center in Tehran (Iran) in 2019. Out of the given population, 32 individuals were selected by adopting convenience sampling method and, then, were randomly divided into schema therapy (n=16) and control (n=16) groups. Data were obtained using body mass index (BMI), Cooper Smith self-esteem questionnaire, and body image questionnaire. The data were analyzed by using repeated-measures analysis of variance and SPSS 22 software. The significance level of the tests was set at 0.05. Results: The results showed that schema therapy had a significant effect on the weight (P<0.001), body image (P<0.001), and self-esteem (P<0.001) compared to the control group. The results also revealed that BMI and self-esteem were significantly improved by schema therapy training (P<0.001). Conclusion: It was concluded that schema therapy had a positive effect on weight, body image, and selfesteem in people with obesity.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131773013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Exercise training has been shown to induce transient changes in immunity responses. Researchers have reported conflicting results about the effect of vigorous exercise training on immunoglobulins levels. Due to the lack of consistent existing findings as well as the lack of sufficient studies to clarify some of the ambiguities associated with scientific inconsistencies, this study aimed to examine the effect of short-term beta-hydroxy-beta-methyl butyrate (HMB) supplementation on serum immunoglobulin A (IgA) and immunoglobulin G (IgG) levels in male wrestlers after an exhaustive exercise. Methods: In this randomized clinical trial conducted at the IKIU Sports Physiology Laboratory in Qazvin, Iran, January 2019, 16 wrestlers completed an informed consent form and, then, were randomly divided into two groups (i.e., the supplement group (n=8) and the control group (n=8)). The supplement group received daily 40 mg/kg body weight HMB supplement over two weeks (about 3 g/day). As for the control group, starch was used as a placebo. Blood samples were obtained from the subjects to measure the serum immunoglobulin in five phases, including the pre-supplementation, before, immediately after, 1 hour after, and 24 hours after the exercise protocol. "Bruce test until exhaustion" was adopted as the exercise protocol in this study. Data analysis was performed by using repeated measure analysis and SPSS 24 software. Results: The results showed that there was no significant difference between the groups regarding the effects of supplementation of HMB on IgG (P=0.75) and IgA (P=0.56) levels. However, significant changes were observed in the levels of IgA (P=0.049) and IgG (P=0.001) in the groups. Conclusion: According to the study results, It was suggested that the use of HMB supplementation at the dose used in this study may not have significantly affected the IgG and IgA levels after an exhaustive activity. However, it was recommended that further studies be carried out in this area to produce more consistent findings and clarify the ambiguities about the given issue.
背景:运动训练已被证明可以诱导免疫反应的短暂变化。关于剧烈运动训练对免疫球蛋白水平的影响，研究人员报告了相互矛盾的结果。由于缺乏一致的现有研究结果，以及缺乏足够的研究来澄清与科学不一致性相关的一些歧义，本研究旨在研究短期补充β -羟基- β -丁酸甲酯(HMB)对男性摔跤运动员在彻底运动后血清免疫球蛋白A (IgA)和免疫球蛋白G (IgG)水平的影响。方法:这项随机临床试验于2019年1月在伊朗Qazvin的IKIU运动生理学实验室进行，16名摔跤运动员填写知情同意书，然后随机分为两组(即补充组(n=8)和对照组(n=8))。添加组每天添加40 mg/kg体重的HMB，持续2周(约3 g/d)。至于对照组，淀粉被用作安慰剂。采集受试者血样，分补充前、运动前、运动后、运动后1小时、运动后24小时五个阶段测定血清免疫球蛋白。本研究采用“Bruce test until exhaustion”作为运动方案。数据分析采用重复测量分析和SPSS 24软件。结果:各组间添加HMB对仔猪IgG (P=0.75)和IgA (P=0.56)水平的影响无显著差异。然而，各组IgA (P=0.049)和IgG (P=0.001)水平有显著变化。结论:根据研究结果，本研究中使用的剂量的HMB补充剂在穷尽活动后可能不会显著影响IgG和IgA水平。但是，有人建议在这方面进行进一步的研究，以得出更一致的结论，并澄清有关这一问题的含糊之处。
{"title":"The Effect of Short-term Beta-hydroxy Beta-methylbutyrate Supplementation on Serum Immunoglobulin A and G Levels in Male Wrestlers Following an Exhaustive Exercise: A Randomized Clinical Trial","authors":"Mona Madelat, A. Sadeghi, Ali Hematti Afif","doi":"10.34172/hmj.2022.16","DOIUrl":"https://doi.org/10.34172/hmj.2022.16","url":null,"abstract":"Background: Exercise training has been shown to induce transient changes in immunity responses. Researchers have reported conflicting results about the effect of vigorous exercise training on immunoglobulins levels. Due to the lack of consistent existing findings as well as the lack of sufficient studies to clarify some of the ambiguities associated with scientific inconsistencies, this study aimed to examine the effect of short-term beta-hydroxy-beta-methyl butyrate (HMB) supplementation on serum immunoglobulin A (IgA) and immunoglobulin G (IgG) levels in male wrestlers after an exhaustive exercise. Methods: In this randomized clinical trial conducted at the IKIU Sports Physiology Laboratory in Qazvin, Iran, January 2019, 16 wrestlers completed an informed consent form and, then, were randomly divided into two groups (i.e., the supplement group (n=8) and the control group (n=8)). The supplement group received daily 40 mg/kg body weight HMB supplement over two weeks (about 3 g/day). As for the control group, starch was used as a placebo. Blood samples were obtained from the subjects to measure the serum immunoglobulin in five phases, including the pre-supplementation, before, immediately after, 1 hour after, and 24 hours after the exercise protocol. \"Bruce test until exhaustion\" was adopted as the exercise protocol in this study. Data analysis was performed by using repeated measure analysis and SPSS 24 software. Results: The results showed that there was no significant difference between the groups regarding the effects of supplementation of HMB on IgG (P=0.75) and IgA (P=0.56) levels. However, significant changes were observed in the levels of IgA (P=0.049) and IgG (P=0.001) in the groups. Conclusion: According to the study results, It was suggested that the use of HMB supplementation at the dose used in this study may not have significantly affected the IgG and IgA levels after an exhaustive activity. However, it was recommended that further studies be carried out in this area to produce more consistent findings and clarify the ambiguities about the given issue.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134547234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nahid Soltani, P. Jafari, M. Bagheri, Nader Gholi Ghorchian
Background: Universities of medical sciences, as organizations that ensure the progress of society in the fields of health, treatment, and medical education, have been considered in many ways. The first important goal in these universities is student satisfaction and promotion strategies. Therefore, in this study we presented a model of satisfaction promotion among the students of Hormozgan University of Medical Sciences, Iran. Methods: The population of this applied quantitative research included students of Hormozgan University of Medical Sciences. A total of 380 people were selected by multi-stage cluster sampling. The data collection tool included a researcher-made questionnaire whose validity and reliability were confirmed. Decision making trial and evaluation laboratory (DEMATEL) method, importance-performance analysis (IPA), as well as MATLAB and Excel software were used for quantitative data analysis. Results: The results of IPA showed that the research dimension was of great importance for students and the performance of the university was appropriate in this dimension. Welfare and management dimensions were of little importance, but the performance of the university was high in these dimensions. The administrative component of this dimension was not very important and the university’s performance was not good in it. The support services dimension was very important for students’ satisfaction but the performance of the university was at a low level. As a result, support services had the highest priority for improvement and the welfare, managerial, educational, research and administrative dimensions were in the next ranks for improvement, respectively. The results of causal relationships between dimensions showed that the managerial dimension had the most interaction (impact and effectiveness), followed by research, welfare, education, supportive, and administrative dimensions. The management dimension was the most effective one. According to R-J values, educational and research dimensions were the most effective dimensions, respectively. Conclusion: The results of the present study showed that university policy-makers and administrators need to recognize the basic needs of students in various fields such as education, research, welfare, etc. before taking policy actions, decision-making, and future orientations.
{"title":"A Model of Satisfaction Promotion for Students of Hormozgan University of Medical Sciences in Iran","authors":"Nahid Soltani, P. Jafari, M. Bagheri, Nader Gholi Ghorchian","doi":"10.34172/hmj.2022.08","DOIUrl":"https://doi.org/10.34172/hmj.2022.08","url":null,"abstract":"Background: Universities of medical sciences, as organizations that ensure the progress of society in the fields of health, treatment, and medical education, have been considered in many ways. The first important goal in these universities is student satisfaction and promotion strategies. Therefore, in this study we presented a model of satisfaction promotion among the students of Hormozgan University of Medical Sciences, Iran. Methods: The population of this applied quantitative research included students of Hormozgan University of Medical Sciences. A total of 380 people were selected by multi-stage cluster sampling. The data collection tool included a researcher-made questionnaire whose validity and reliability were confirmed. Decision making trial and evaluation laboratory (DEMATEL) method, importance-performance analysis (IPA), as well as MATLAB and Excel software were used for quantitative data analysis. Results: The results of IPA showed that the research dimension was of great importance for students and the performance of the university was appropriate in this dimension. Welfare and management dimensions were of little importance, but the performance of the university was high in these dimensions. The administrative component of this dimension was not very important and the university’s performance was not good in it. The support services dimension was very important for students’ satisfaction but the performance of the university was at a low level. As a result, support services had the highest priority for improvement and the welfare, managerial, educational, research and administrative dimensions were in the next ranks for improvement, respectively. The results of causal relationships between dimensions showed that the managerial dimension had the most interaction (impact and effectiveness), followed by research, welfare, education, supportive, and administrative dimensions. The management dimension was the most effective one. According to R-J values, educational and research dimensions were the most effective dimensions, respectively. Conclusion: The results of the present study showed that university policy-makers and administrators need to recognize the basic needs of students in various fields such as education, research, welfare, etc. before taking policy actions, decision-making, and future orientations.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"353 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132299097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kimia Seddighi, A. Rahimi, A. Azarbad, Ali Salimi Asl, Masoomeh Mahmoudi, Saba Khanjani Moaf, Hesamaddin Kamal Zadeh Takhti, Masoumeh Kheirandish
Background: According to the evidence, coronavirus disease 2019 (COVID-19) is associated with significant mortality among hospitalized patients. Corticosteroid drugs have had different effects on disease-associated fatality. This study aimed to evaluate the corticosteroid-associated mortality rate and its related risk factors in the southern Iranian population infected by COVID-19. Methods: A retrospective study was conducted on the adult population aged≥20 years admitted to Shahid Mohammadi hospital in Bandar Abbas, Iran between February 2020 and October 2020. All subjects were confirmed for COVID-19 by reverse transcriptase-polymerase chain reaction (RT-PCR). Results: Among 1610 included cases, 150 (9.3%) died. Also, 58.5% and 58.7% of the total hospitalized and mortality cases were male, respectively. The mortality rate in subjects older than 60 years was 2.5 times higher than patients aged 40 years, which was statistically significant (P<0.001). The results of logistic regression analysis revealed that age was the most significant risk factor for mortality. The elderly patients (>60) had nearly ten times higher chance of fatality than patients aged less than 40 years (adjusted odds ratio [aOR]: 9.79, 95% CI: 4.41-21.74). Using corticosteroids independently increased the chance of mortality by 50% (aOR: 1.53, 95% CI: 1.06-2.22). Low oxygen saturation (<93%) raised mortality rate by more than 3.5 times compared to oxygen saturation≥93% (aOR: 3.67, CI 95: 2.54-5.31). In addition, ischemic heart disease (IHD) was another remarkable predictor of death (aOR: 2.85, 95% CI: 1.88-4.31). Conclusion: According to our results, corticosteroids had no benefits for reducing the mortality rates among COVID-19 patients. Further randomized clinical trials are suggested to evaluate the effects of corticosteroids on COVID-19-related mortality.
{"title":"Association between Administration of Corticosteroids and Mortality among Iranian Patients with COVID-19, A Retrospective Study","authors":"Kimia Seddighi, A. Rahimi, A. Azarbad, Ali Salimi Asl, Masoomeh Mahmoudi, Saba Khanjani Moaf, Hesamaddin Kamal Zadeh Takhti, Masoumeh Kheirandish","doi":"10.34172/hmj.2022.10","DOIUrl":"https://doi.org/10.34172/hmj.2022.10","url":null,"abstract":"Background: According to the evidence, coronavirus disease 2019 (COVID-19) is associated with significant mortality among hospitalized patients. Corticosteroid drugs have had different effects on disease-associated fatality. This study aimed to evaluate the corticosteroid-associated mortality rate and its related risk factors in the southern Iranian population infected by COVID-19. Methods: A retrospective study was conducted on the adult population aged≥20 years admitted to Shahid Mohammadi hospital in Bandar Abbas, Iran between February 2020 and October 2020. All subjects were confirmed for COVID-19 by reverse transcriptase-polymerase chain reaction (RT-PCR). Results: Among 1610 included cases, 150 (9.3%) died. Also, 58.5% and 58.7% of the total hospitalized and mortality cases were male, respectively. The mortality rate in subjects older than 60 years was 2.5 times higher than patients aged 40 years, which was statistically significant (P<0.001). The results of logistic regression analysis revealed that age was the most significant risk factor for mortality. The elderly patients (>60) had nearly ten times higher chance of fatality than patients aged less than 40 years (adjusted odds ratio [aOR]: 9.79, 95% CI: 4.41-21.74). Using corticosteroids independently increased the chance of mortality by 50% (aOR: 1.53, 95% CI: 1.06-2.22). Low oxygen saturation (<93%) raised mortality rate by more than 3.5 times compared to oxygen saturation≥93% (aOR: 3.67, CI 95: 2.54-5.31). In addition, ischemic heart disease (IHD) was another remarkable predictor of death (aOR: 2.85, 95% CI: 1.88-4.31). Conclusion: According to our results, corticosteroids had no benefits for reducing the mortality rates among COVID-19 patients. Further randomized clinical trials are suggested to evaluate the effects of corticosteroids on COVID-19-related mortality.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131180275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Javad Shafahi, M. Salesi, Rasoul Rezaei, F. Daryanoosh
Background: Nuclear factor-erythroid-2-related factor 2 (Nrf2) is an inducible transcription factor that improves redox balance through stimulating antioxidant gene expression. Objectives: Studies have shown that Nrf2 can be modulated by physical exercise. However, the impact of resistance training and coenzyme Q10 supplementation has never been investigated. The aim of this study was to evaluate the effects of two months of resistance exercise and coenzyme Q10 supplementation on the expression of Nrf2 and NAD(P)quinone acceptor oxidoreductase 1 (NQO1) in young male rats. Methods: In this semi-experimental study, a total of 36 male and young Sprague Dawley rats (age: 8 weeks) were randomly assigned into six groups as follows: resistance training (RT), training and supplementation of 200 mg/kg of rat weight (RT + Q200), training and supplementation and 300 mg/kg (RT + Q300), supplementary group with the value of 200 mg/kg (Q200), supplementary group with the value of 300 mg/ kg (Q300), and control. The resistance training protocol consisted of three set of five repetitions of trained rats climbing a vertical ladder with an extra load attached to the tail, representing 30–100% of total body mass three times per week for eight weeks. The proteins levels of Nrf2 and NQO1 were measured by Western blotting technique. One-way analysis of variance (ANOVA), and in case of statistically significant difference, Tukey’s post-hoc test were used to determine the difference between groups. Results: The results showed that the expression of Nrf2 and NQO1 levels changed in the groups after the end of the period. While the expression of Nrf2 and NQO1 significantly increased in the RT and RT + Q200 groups (P<0.001). Conclusion: The results of present study showed that resistance training provides a beneficial adaptation to Nrf2 and NQO1 activity, which can be further enhanced by Q10 supplementation with antioxidant effects.
背景:核因子-红细胞2相关因子2 (Nuclear factor-erythroid-2-related factor 2, Nrf2)是一种通过刺激抗氧化基因表达来改善氧化还原平衡的诱导性转录因子。目的:研究表明，Nrf2可以通过体育锻炼调节。然而，阻力训练和辅酶Q10补充的影响从未被研究过。本研究的目的是评估两个月的阻力运动和辅酶Q10补充对年轻雄性大鼠Nrf2和NAD(P)醌受体氧化还原酶1 (NQO1)表达的影响。方法:采用半实验方法，将36只8周龄雄性和幼龄Sprague Dawley大鼠随机分为6组:阻力训练组(RT)、训练并补充大鼠体重200 mg/kg (RT + Q200)、训练并补充300 mg/kg (RT + Q300)、补充组(Q200)、补充组(300 mg/kg)和对照组。阻力训练方案包括三组，每组五次重复，训练大鼠爬一个垂直梯子，尾巴附加额外的负荷，每周三次，占总体重的30-100%，持续八周。Western blotting检测Nrf2和NQO1蛋白表达水平。采用单因素方差分析(ANOVA)，若差异有统计学意义，采用Tukey’s事后检验确定组间差异。结果:实验结束后，各组Nrf2和NQO1表达水平发生变化。而RT和RT + Q200组Nrf2、NQO1的表达显著升高(P<0.001)。结论:本研究结果表明，抗阻训练对Nrf2和NQO1活性具有有益的调节作用，并可通过补充辅酶Q10进一步增强其抗氧化作用。
{"title":"The Impact of Resistance Training With Coenzyme Q10 Supplementation on Antioxidant Value of Nuclear Factor-Erythroid-2-Related Factor 2 in Young Male Rats","authors":"Mohammad Javad Shafahi, M. Salesi, Rasoul Rezaei, F. Daryanoosh","doi":"10.34172/hmj.2022.02","DOIUrl":"https://doi.org/10.34172/hmj.2022.02","url":null,"abstract":"Background: Nuclear factor-erythroid-2-related factor 2 (Nrf2) is an inducible transcription factor that improves redox balance through stimulating antioxidant gene expression. Objectives: Studies have shown that Nrf2 can be modulated by physical exercise. However, the impact of resistance training and coenzyme Q10 supplementation has never been investigated. The aim of this study was to evaluate the effects of two months of resistance exercise and coenzyme Q10 supplementation on the expression of Nrf2 and NAD(P)quinone acceptor oxidoreductase 1 (NQO1) in young male rats. Methods: In this semi-experimental study, a total of 36 male and young Sprague Dawley rats (age: 8 weeks) were randomly assigned into six groups as follows: resistance training (RT), training and supplementation of 200 mg/kg of rat weight (RT + Q200), training and supplementation and 300 mg/kg (RT + Q300), supplementary group with the value of 200 mg/kg (Q200), supplementary group with the value of 300 mg/ kg (Q300), and control. The resistance training protocol consisted of three set of five repetitions of trained rats climbing a vertical ladder with an extra load attached to the tail, representing 30–100% of total body mass three times per week for eight weeks. The proteins levels of Nrf2 and NQO1 were measured by Western blotting technique. One-way analysis of variance (ANOVA), and in case of statistically significant difference, Tukey’s post-hoc test were used to determine the difference between groups. Results: The results showed that the expression of Nrf2 and NQO1 levels changed in the groups after the end of the period. While the expression of Nrf2 and NQO1 significantly increased in the RT and RT + Q200 groups (P<0.001). Conclusion: The results of present study showed that resistance training provides a beneficial adaptation to Nrf2 and NQO1 activity, which can be further enhanced by Q10 supplementation with antioxidant effects.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129770704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Dehghani, Hoda Soofi, I. Shahramian, A. Bazi, N. Honar, A. Mani, A. Erjaee
Background: Functional constipation (FC) is one of the most common complaints in childhood. The aim of this study was the evaluation of the quality of life in children with chronic FC and their family members. Methods: In this study, 100 children from 2-18 years of age (57 males, 43 females) with chronic FC were selected. The Child Health Questionnaire - Parent Form 50 questionnaire was used for quality of life assessment in children and their family members. Quality of life scores were compared with 100 healthy children from 2-18 years of age. The questionnaire consists of 15 domains, each of which ranges in score from zero to 100. A higher score represents a better quality of life. Results: Quality of life scores in all 15 domains were significantly lower in children with FC than in healthy children (P<0.001). Scores of physical functioning, behavior, and mental health were lower in children with FC and fecal incontinence compared to children with FC alone (P<0.05). Conclusion: FC impacts on quality of life of the affected children and their family members. Practitioners should be aware of its effects on quality of life to improve the disease course with early assessment and treatment.
{"title":"Quality of Life in Children With Chronic Functional Constipation and Their Family Members","authors":"S. Dehghani, Hoda Soofi, I. Shahramian, A. Bazi, N. Honar, A. Mani, A. Erjaee","doi":"10.34172/hmj.2022.09","DOIUrl":"https://doi.org/10.34172/hmj.2022.09","url":null,"abstract":"Background: Functional constipation (FC) is one of the most common complaints in childhood. The aim of this study was the evaluation of the quality of life in children with chronic FC and their family members. Methods: In this study, 100 children from 2-18 years of age (57 males, 43 females) with chronic FC were selected. The Child Health Questionnaire - Parent Form 50 questionnaire was used for quality of life assessment in children and their family members. Quality of life scores were compared with 100 healthy children from 2-18 years of age. The questionnaire consists of 15 domains, each of which ranges in score from zero to 100. A higher score represents a better quality of life. Results: Quality of life scores in all 15 domains were significantly lower in children with FC than in healthy children (P<0.001). Scores of physical functioning, behavior, and mental health were lower in children with FC and fecal incontinence compared to children with FC alone (P<0.05). Conclusion: FC impacts on quality of life of the affected children and their family members. Practitioners should be aware of its effects on quality of life to improve the disease course with early assessment and treatment.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125547957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Cardiovascular disease (CVD), a chronic and debilitating physical condition, is one of the most common causes of death. Complications of CVD, such as decreased physical and mental health along with its chronic, progressive, and irreversible nature have numerous negative consequences for patients. This study aimed to investigate the mediating role of perceived stress in the relationship between psychological hardiness and quality of life (QoL) in cardiovascular patients. Methods: The present study was a descriptive-correlational and structural equation modeling. The statistical population included all patients with CVD referred to heart hospitals and cardiac rehabilitation centers in Tehran, Iran in 2019. Using purposeful sampling method, a total of 151 individuals were selected. Data collection tools included a Kobasa Psychological Hardiness Questionnaire, Cohen’s Perceived Stress Questionnaire, and Quality of Life Scale (SF-36). To analyze the data, Pearson’s correlation coefficient and path analysis with SPSS.22 and Amos.22 software were used. Results: The results showed that negative perception of stress and positive perception of stress had a significant negative and positive relationship with dimensions of QoL, respectively (P<0.001). Psychological hardiness had a significant positive relationship with dimensions of QoL (P<0.001). Also, perceived stress had a mediating role in the relationship between psychological hardiness and QoL dimensions (P<0.001). Conclusion: The results of the present study indicated a correlation between psychological hardiness and increased QoL and the inverse relationship between perceived stress and QoL in cardiovascular patients.
{"title":"The Mediating Role of Perceived Stress in the Relationship Between Psychological Hardiness and Quality of Life in Cardiovascular Patients","authors":"Monir Javer, A. Rafiepoor, M. Sabet","doi":"10.34172/hmj.2022.01","DOIUrl":"https://doi.org/10.34172/hmj.2022.01","url":null,"abstract":"Background: Cardiovascular disease (CVD), a chronic and debilitating physical condition, is one of the most common causes of death. Complications of CVD, such as decreased physical and mental health along with its chronic, progressive, and irreversible nature have numerous negative consequences for patients. This study aimed to investigate the mediating role of perceived stress in the relationship between psychological hardiness and quality of life (QoL) in cardiovascular patients. Methods: The present study was a descriptive-correlational and structural equation modeling. The statistical population included all patients with CVD referred to heart hospitals and cardiac rehabilitation centers in Tehran, Iran in 2019. Using purposeful sampling method, a total of 151 individuals were selected. Data collection tools included a Kobasa Psychological Hardiness Questionnaire, Cohen’s Perceived Stress Questionnaire, and Quality of Life Scale (SF-36). To analyze the data, Pearson’s correlation coefficient and path analysis with SPSS.22 and Amos.22 software were used. Results: The results showed that negative perception of stress and positive perception of stress had a significant negative and positive relationship with dimensions of QoL, respectively (P<0.001). Psychological hardiness had a significant positive relationship with dimensions of QoL (P<0.001). Also, perceived stress had a mediating role in the relationship between psychological hardiness and QoL dimensions (P<0.001). Conclusion: The results of the present study indicated a correlation between psychological hardiness and increased QoL and the inverse relationship between perceived stress and QoL in cardiovascular patients.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129667123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Urinary tract infection (UTI) is among the most common infections in children and acute pyelonephritis (APN) is the most important type of UTI. Late diagnosis and treatment of APN can result in severe complications. This study aimed to evaluate the effect of vitamin E on renal scars in children aged three months to 14 years. Methods: This single-blinded randomized clinical trial (RCT) included all children aged three months to 14 years admitted to tBandar Abbas Children’s Hospital, Bandar Abbas, Iran due to APN in 2017-2018. Patients with renal scars were alternately randomized into two groups. The control group included 41 patients who received 50-75 mg/kg/d intravenous ceftriaxone during hospital stay and the intervention group included 37 cases who received 20 U/kg/d vitamin E tablets in addition to the previous treatment for a total duration of 4 months. Dimercaptosuccinic acid (DMSA) scan was performed at baseline and at the end of 4 months. Results: Out of a total of 78 patients, 34 (43.6%) were boys. Participants of both groups were comparable regarding age and gender. The median of decrease in photopenic areas was insignificantly higher in girls in the vitamin E group compared to girls in the control group (1.26 vs. 1.17, P=0.459). Regardless of gender, decrease in photopenic areas was insignificantly higher in patients aged 1-3 years in the vitamin E group compared to those in the control group (1.40 vs. 1.22, P=0.451). Conclusion: Treatment with vitamin E for at least 4 months may reduce renal scarring in children aged 1-3 years and girls with APN.
背景:尿路感染(UTI)是儿童最常见的感染之一，急性肾盂肾炎(APN)是最重要的尿路感染类型。APN的晚期诊断和治疗可导致严重的并发症。本研究旨在评估维生素E对3个月至14岁儿童肾瘢痕的影响。方法:该单盲随机临床试验(RCT)纳入2017-2018年伊朗阿巴斯港阿巴斯儿童医院因APN入院的所有3个月至14岁儿童。肾瘢痕患者交替随机分为两组。对照组41例患者住院期间静脉注射头孢曲松50 ~ 75 mg/kg/d;干预组37例患者在既往治疗基础上静脉注射维生素E片20 U/kg/d，疗程共4个月。在基线和4个月结束时进行二巯基琥珀酸(DMSA)扫描。结果:78例患者中，34例(43.6%)为男孩。两组参与者的年龄和性别具有可比性。与对照组相比，维生素E组女孩的光斑面积减少的中位数没有显著提高(1.26 vs. 1.17, P=0.459)。不论性别，1-3岁的患者中，维生素E组的光衰区减少量均不显著高于对照组(1.40 vs. 1.22, P=0.451)。结论:维生素E治疗至少4个月可减少1-3岁APN患儿和女童肾瘢痕形成。
{"title":"Effect of Vitamin E on Renal Scarring in Children With Acute Pyelonephritis: A Randomized Controlled Clinical Trial","authors":"K. Ghasemi, Maryam Esteghamati, Khatereh Arjeh","doi":"10.34172/hmj.2022.05","DOIUrl":"https://doi.org/10.34172/hmj.2022.05","url":null,"abstract":"Background: Urinary tract infection (UTI) is among the most common infections in children and acute pyelonephritis (APN) is the most important type of UTI. Late diagnosis and treatment of APN can result in severe complications. This study aimed to evaluate the effect of vitamin E on renal scars in children aged three months to 14 years. Methods: This single-blinded randomized clinical trial (RCT) included all children aged three months to 14 years admitted to tBandar Abbas Children’s Hospital, Bandar Abbas, Iran due to APN in 2017-2018. Patients with renal scars were alternately randomized into two groups. The control group included 41 patients who received 50-75 mg/kg/d intravenous ceftriaxone during hospital stay and the intervention group included 37 cases who received 20 U/kg/d vitamin E tablets in addition to the previous treatment for a total duration of 4 months. Dimercaptosuccinic acid (DMSA) scan was performed at baseline and at the end of 4 months. Results: Out of a total of 78 patients, 34 (43.6%) were boys. Participants of both groups were comparable regarding age and gender. The median of decrease in photopenic areas was insignificantly higher in girls in the vitamin E group compared to girls in the control group (1.26 vs. 1.17, P=0.459). Regardless of gender, decrease in photopenic areas was insignificantly higher in patients aged 1-3 years in the vitamin E group compared to those in the control group (1.40 vs. 1.22, P=0.451). Conclusion: Treatment with vitamin E for at least 4 months may reduce renal scarring in children aged 1-3 years and girls with APN.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122724000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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