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2007 IEEE Biomedical Circuits and Systems Conference最新文献

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Visualizing Genetic Circuits Using Concepts Borrowed from Electronics 利用借用电子学的概念可视化遗传电路
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463324
S. Davies
Biology features genetic circuits that are analogous to electronic circuits. A major goal of synthetic biology is the engineering of new genetic circuits. Inspired by electronic circuit diagrams, this paper proposes a means of representing these genetic circuits that facilitates analysis and effectively communicates circuit properties.
生物学的特点是遗传电路类似于电子电路。合成生物学的一个主要目标是设计新的遗传电路。受电子电路图的启发,本文提出了一种表示这些遗传电路的方法,便于分析和有效地传达电路特性。
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引用次数: 2
Design of Low-Power Low-Voltage Biomedical Amplifier for Electrocardiogram Signal Recording 用于心电图信号记录的低功率低压生物医学放大器的设计
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463341
E.C.M. Lim, X. Zou, Yuanjin Zheng, Jun‐Kai Tan
The demand for health-monitoring products is increasing worldwide. Low-power and low-voltage attributes are important concerns that need to be addressed in circuits used for personal health-monitoring applications, to achieve a long battery life. In this paper, a biomedical amplifier is designed for electrocardiogram (ECG) signal detection. The design comprises of a high pass filter (HPF), an operational transconductance amplifier (OTA), two dB-linear variable gain amplifiers, three low pass filters (LPF), and an operational transresistance amplifier (ORA). In particular, the VGA and the LPF uses the log companding technique. The bio-amplifier consumes less than 20 muW of power from a 1 V single supply. The circuit is implemented in 0.18 mum CMOS technology.
全球对健康监测产品的需求正在增加。在用于个人健康监测应用的电路中,低功耗和低电压属性是需要解决的重要问题,以实现较长的电池寿命。本文设计了一种用于心电信号检测的生物医学放大器。该设计包括一个高通滤波器(HPF)、一个运算跨导放大器(OTA)、两个db线性变增益放大器、三个低通滤波器(LPF)和一个运算跨阻放大器(ORA)。特别是VGA和LPF使用了日志扩展技术。生物放大器从1v单电源中消耗的功率小于20muw。该电路采用0.18 μ m CMOS技术实现。
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引用次数: 10
Assistive Technology for Promoting Physical and Mental Exercise to Delay Progression of Cognitive Degeneration in Patients with Dementia 促进身心锻炼以延缓痴呆患者认知退化进展的辅助技术
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463352
Naveen Chilukoti, Kenneth Early, Sarvinder Sandhu, Cheryl Riley-Doucet, D. Debnath
Alzheimer's disease is one of the top ten leading causes of death in the United States. A recent study by The Johns Hopkins University estimated that by 2050, one in 85 people worldwide will be living with Alzheimer's disease. According to the study, if intervention could delay the progression of the disease by a modest one year, there would be about 3.7 million fewer patients with the disease who require high level of care such as a nursing home in 2050. Research suggests that the combination of physical and mental exercise reduces the progression of cognitive degeneration. The paper focuses on creating an assistive technology system to promote both physical exercise and cognitive stimulation for patients suffering from Alzheimer's disease and other dementias. The system incorporates a portable mini stationary bike and an interactive visual multiple choice question game. Physical exercise is provided by the bike while cognitive stimulation is provided by the game that targets areas such as memory, judgment, problem solving, recollection, and matching, to impede dementia. Research has shown that certain multi-sensory stimulants such as fiber optic lights and selective colors can be used to relax and control agitation of patients with dementia. By incorporating these stimulants into the design, we have created a safe and fun way for patients with dementia to complete physical and mental exercise.
阿尔茨海默病是美国十大主要死亡原因之一。约翰霍普金斯大学最近的一项研究估计,到2050年,全球每85人中就有一人患有阿尔茨海默病。根据这项研究,如果干预可以将疾病的进展稍微推迟一年,那么到2050年,需要高水平护理(如养老院)的患者将减少约370万。研究表明,身体和精神锻炼的结合可以减少认知退化的进展。本文的重点是创建一个辅助技术系统,以促进阿尔茨海默病和其他痴呆症患者的体育锻炼和认知刺激。该系统包括一个便携式迷你固定自行车和一个交互式视觉选择题游戏。自行车提供体育锻炼,而游戏提供认知刺激,以记忆、判断、解决问题、回忆和匹配等领域为目标,以防止痴呆症。研究表明,某些多感官刺激物,如光纤光和选择性颜色,可以用来放松和控制痴呆症患者的躁动。通过将这些兴奋剂融入设计中,我们为痴呆症患者创造了一种安全有趣的方式来完成身体和精神锻炼。
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引用次数: 31
A Differential Pressure Approach to Spirometry 肺量测定的压差法
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463295
R. Carta, D. Turgis, B. Hermans, P. Jourand, R. Onclin, R. Puers
This paper presents the design, implementation and measurements of a spirometer based on differential pressure sensing. A system which fulfills the last medical standard specifications has been designed exploiting the Venturi tube principle. A fully operating prototype has been tested, and data have been subsequently analyzed. Air flows up to 14 L/s can be measured with an accuracy of 0.2 L/s. Data acquisition software and user interface were developed.
本文介绍了一种基于差压传感的肺活量计的设计、实现和测量。利用文丘里管原理,设计了一个符合最新医疗标准规范的系统。一个完全运行的原型机已经进行了测试,随后对数据进行了分析。可测量高达14升/秒的空气流量,精度为0.2升/秒。开发了数据采集软件和用户界面。
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引用次数: 20
Long-term monitoring of electrochemical parameters from stimulated neural tissues 长期监测受刺激神经组织的电化学参数
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463300
F. Mounaim, G. Lesbros, M. Sawan
The electrode-tissues interface (ETI) is one of the key issues for the safety, reliability and efficiency of implantable devices such as stimulators and sensors. The aim of this paper is to report an implantable telemetry device, based on a full custom integrated circuit (IC) to monitor the ETI. The proposed system performs various types of measurements, such as impedance spectroscopy, cyclic voltammetry, and galvanostatic double pulse method. Hence, the evolution of various electrochemical parameters of the ETI such as complex impedance, faradic resistance, double layer capacity, rheobase current, and chronaxy time, could be monitored long time after implantation. The full custom IC has been designed and fabricated with the CMOS 0.18 mum technology. The circuit occupies a silicon area of 2 mm2, and consumes less than 3 mW. Characterisation and in-vitro experimental results validate the full functionalities of the implantable monitoring system including the custom IC.
电极-组织界面(ETI)是影响刺激器和传感器等植入式设备安全性、可靠性和效率的关键问题之一。本文的目的是报道一种植入式遥测装置,基于一个完整的定制集成电路(IC)来监测ETI。所提出的系统执行各种类型的测量,如阻抗谱,循环伏安法和恒流双脉冲法。因此,可以在植入后很长一段时间内监测ETI的复杂阻抗、faradic电阻、双层容量、流变电流、时序时间等各种电化学参数的演变。完整的定制IC已设计和制造CMOS 0.18 mum技术。该电路占用的硅面积为2 mm2,功耗小于3 mW。表征和体外实验结果验证了包括定制IC在内的可植入监测系统的全部功能。
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引用次数: 3
MicroLEAP: Energy-aware Wireless Sensor Platform for Biomedical Sensing Applications MicroLEAP:生物医学传感应用的能量感知无线传感器平台
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463333
L. Au, W.H. Wu, M. Batalin, D. Mclntire, W. Kaiser
Extended system lifetime is a critical requirement for wearable sensor platforms. However, these platforms must also accommodate local data processing, data storage, and broadband wireless communications. Since compact battery storage capacity is constrained, there exists a fundamental tradeoff between energy optimization and performance. Furthermore, biomedical transducers may also demand high peak power dissipation during active operations. Energy management, therefore, must be introduced through new hardware architecture and enabled through software in the overall system design. To effectively optimize energy dissipation for biomedical sensing applications, a new wearable sensor platform, MicroLEAP, has been developed. The MicroLEAP platform supports per-task real-time energy profiling to permit adaptive applications that select platform components to best match dynamically-varying measurement requirements. MicroLEAP design, implementation, and example of energy-aware operation are demonstrated.
延长系统寿命是可穿戴传感器平台的关键要求。然而,这些平台还必须适应本地数据处理、数据存储和宽带无线通信。由于紧凑型电池的存储容量受到限制,因此在能量优化和性能之间存在一个基本的权衡。此外,生物医学换能器在主动操作期间也可能需要高峰值功耗。因此,能源管理必须通过新的硬件架构引入,并在整个系统设计中通过软件实现。为了有效优化生物医学传感应用的能量耗散,开发了一种新的可穿戴传感器平台MicroLEAP。MicroLEAP平台支持逐任务实时能量分析,允许自适应应用选择平台组件,以最佳地匹配动态变化的测量要求。演示了MicroLEAP的设计、实现和能耗感知操作示例。
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引用次数: 61
A Low-Noise, Non-Contact EEG/ECG Sensor 一种低噪声、非接触式EEG/ECG传感器
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463332
Thomas J. Sullivan, S. Deiss, G. Cauwenberghs
Typical electroencephalogram (EEG) and electrocardiogram (ECG) sensors require conductive gel to ensure low-impedance electrical contact between the sensor and skin, making set-up time-consuming and long-term recording problematic. We present a gel-free, non-contact EEG/ECG sensor with on-board electrode that capacitively couples to the skin. Active shielding of the high-impedance input significantly reduces noise pickup, and reduces variations in gain as a function of gap distance. The integrated sensor combines amplification, bandpass filtering, and analog-to-digital conversion within a 1 inch diameter enclosure. The measured input-referred noise, over 1-100 Hz frequency range, is 2 muVrms at 0.2 mm sensor distance, and 17 muVrms at 3.2 mm distance. Experiments coupling the sensor to human scalp through hair and to chest through clothing produce clear EEG and ECG recorded signals.
典型的脑电图(EEG)和心电图(ECG)传感器需要导电凝胶来确保传感器和皮肤之间的低阻抗电接触,这使得设置耗时且长期记录存在问题。我们提出了一种无凝胶,非接触式EEG/ECG传感器,其板载电极与皮肤电容耦合。主动屏蔽的高阻抗输入显著降低噪声拾取,并减少增益的变化作为间隙距离的函数。集成传感器在直径1英寸的外壳内结合放大、带通滤波和模数转换。在1- 100hz频率范围内,测量到的输入参考噪声在0.2 mm传感器距离处为2 muVrms,在3.2 mm距离处为17 muVrms。实验通过头发将传感器连接到人的头皮,通过衣服将传感器连接到胸部,产生清晰的脑电图和心电图记录信号。
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引用次数: 191
A software assistant for the design and analysis of neuromuscular tests 用于设计和分析神经肌肉测试的软件助手
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463320
C. O'Reilly, R. Plamondon
An interactive software assistant (SimScript) has been developed to help in the design of neuromuscular tests and in the analysis of data gathered from these tests. The tool is based on the Kinematic Theory of rapid human movements and its Sigma-Lognormal (SigmaLambda) model. It allows the manipulation of the movement kinematics using analytical expressions. Although the project is still exploratory, current work focuses on three long term objectives: improvement of clinical rehabilitation results from stroke-impaired patients, lowering medical cost by helping in the development of at-home rehabilitation exercises and the development of a deeper understanding of the human neuromuscular kinematics properties. This paper briefly summarizes the SigmaLambda model, presents the properties and possibilities of SimScript and presents an example of practical application.
一种交互式软件助手(SimScript)已经开发出来,以帮助设计神经肌肉测试和分析从这些测试中收集的数据。该工具基于人体快速运动的运动学理论及其Sigma-Lognormal (SigmaLambda)模型。它允许使用解析表达式操纵运动运动学。虽然该项目仍处于探索性阶段,但目前的工作主要集中在三个长期目标上:改善中风受损患者的临床康复效果,通过帮助发展家庭康复练习来降低医疗成本,以及对人类神经肌肉运动学特性的深入了解。本文简要总结了SigmaLambda模型,介绍了SimScript的特性和可能性,并给出了一个实际应用的例子。
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引用次数: 7
Current-Mode Temporal Difference CMOS Imager for Capsule Endoscopy 用于胶囊内窥镜的电流模时间差CMOS成像仪
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463348
Ho Yeung Chan, Jie Yuan
A current-mode temporal difference imager for wireless capsule-endoscopy is introduced. The new imager generates low output data rate. Wide dynamic range image can be recovered from the low-rate data at the receiver side. To reduce the circuit charge injection error of the difference imager, a calibration technique for the pixel is developed, and introduced in the paper. The image restoration error is found to be bounded for our calibration scheme. With a designed estimation function, the restoration error is suppressed below 0.1 pA, which enables the imager with 95 dB dynamic range. The hardware cost of the decoder for the calibration scheme is moderate.
介绍了一种用于无线胶囊内窥镜的电流模式时间差成像仪。新的成像仪产生低输出数据速率。从接收端的低速率数据中可以恢复出宽动态范围的图像。为了减小差分成像仪的电路电荷注入误差,本文提出了一种像元校正技术。发现我们的校正方案的图像恢复误差是有界的。通过设计的估计函数,恢复误差被抑制在0.1 pA以下,使成像仪具有95 dB的动态范围。该校准方案的解码器硬件成本适中。
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引用次数: 4
Network Characteristics of Urban Environments for Wireless BAN 城市环境无线BAN网络特性研究
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463338
M. Motani, Kok-Kiong Yap, A. Natarajan, B. de Silva, Siquan Hu, K. Chua
The fast growing elderly population has rendered a need for cheaper and better healthcare. Answering this call are advances in information technology and medical sciences. At the information technology end, wireless body area networks (WBAN) are being developed to support continuous and ubiquitous monitoring of patients. In our previous work, we identified the importance of the environment in the design of WBAN. Therefore, we characterize the effects of the urban environment on networking with these low power communication devices. We begin by observing the effects of some less studied factors, such as height of devices and impact of human contact on the antenna. We then present results on the characterization of two environments, namely residential housing and the university campus. Our results show that despite WiFi being omnipresent, its impact on reception probability is not significant. Thus, there is no preferred channel to operate a WBAN.
快速增长的老年人口使人们需要更便宜、更好的医疗保健。响应这一号召的是信息技术和医学科学的进步。在信息技术方面,无线体域网络(WBAN)正在发展,以支持对患者的连续和无处不在的监测。在我们之前的工作中,我们确定了WBAN设计中环境的重要性。因此,我们描述了城市环境对这些低功耗通信设备联网的影响。我们首先观察一些研究较少的因素的影响,如设备的高度和人类接触对天线的影响。然后,我们提出了两种环境的表征结果,即住宅和大学校园。我们的研究结果表明,尽管WiFi无处不在,但它对接收概率的影响并不显著。因此,不存在操作WBAN的首选信道。
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引用次数: 13
期刊
2007 IEEE Biomedical Circuits and Systems Conference
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