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2007 IEEE Biomedical Circuits and Systems Conference最新文献

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Breast Lesions Classification Using Modified Non-Recursive Discrete Biorthogonal Wavelet Transform 基于改进非递归离散双正交小波变换的乳腺病变分类
Pub Date : 2007-12-01 DOI: 10.1109/BIOCAS.2007.4463349
Hsieh-Wei Lee, S. Lei, K. Hung, Bin-Da Liu
Infiltrative nature on ultrasound images is a significant feature implying a malignant breast lesion. Characterizing the infiltrative nature with high effective and computationally inexpensive features is crucial for realizing computer-aided diagnosis. In this paper, the infiltrative nature is sighted as irregularly local variance in a 1-D signal, which is induced due to the existence of some high octave energies. These energies are extractable by a modified 1-D non-recursive discrete biorthogonal wavelet transform. The experimental results show that the proposed wavelet-based features have high individual feature efficacy and the capability of improving combined feature performance.
超声图像的浸润性是乳腺恶性病变的重要特征。高效且计算成本低廉的浸润性质表征是实现计算机辅助诊断的关键。本文将浸润性看作是一维信号中由于某些高倍频能量的存在而引起的不规则局部方差。这些能量可通过改进的一维非递归离散双正交小波变换提取。实验结果表明,所提出的小波特征具有较高的个体特征有效性和提高组合特征性能的能力。
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引用次数: 2
Feasibility Study of Printed Capsule Antennas for Medication Compliance Monitoring 打印胶囊天线用于药物依从性监测的可行性研究
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463304
Hong Yu, G. Flores, S. Reza, G. Irby, C. Batich, R. Bashirullah, V. Meka, D. M. Peterson, N. Euliano
This paper presents a feasibility study of printed capsule antennas for medication compliance monitoring. During clinical trials, it is important to know with certainty a patient's compliance to a medication regimen, because without it, the results cannot be interpreted accurately. Small antennas printed directly onto the surface of standard capsule can potentially serve as a cost-effective method of validating medication compliance via electronic detection of a swallowed pill in the digestive tract. In this paper, we investigate various aspects of these "electronics pills," including printing methods, conductive inks and radiation characteristics of electrically small antennas inside the human body. We employ realistic antenna models and electromagnetic simulations based on the finite difference time domain method to determine the radiated field intensities for sources in the body. Phantoms solutions with electrical properties that are approximately equivalent to biological tissue are used to experimentally validate simulated results and characterize signal attenuation of electrically small radiation sources in the human torso.
本文对打印胶囊天线用于药物依从性监测的可行性进行了研究。在临床试验中,确切地了解患者对药物治疗方案的依从性是很重要的,因为没有它,就不能准确地解释结果。直接印在标准胶囊表面的小天线有可能作为一种经济有效的方法,通过电子检测消化道中吞下的药丸来验证药物依从性。在本文中,我们研究了这些“电子药丸”的各个方面,包括印刷方法、导电油墨和人体内电子小天线的辐射特性。我们采用真实的天线模型和基于时域有限差分法的电磁模拟来确定体内源的辐射场强。具有近似等效于生物组织的电学特性的幻影溶液用于实验验证模拟结果并表征人体躯干中电小辐射源的信号衰减。
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引用次数: 3
High Throughput Algorithm for Leukemia Cell Population Statistics on a Hemocytometer 血细胞计白血病细胞群统计的高通量算法
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463329
B. Prasad, Wael Badawy
This paper presents a high throughput cell count and cluster classification algorithm to quantify population statistics of leukemia cell lines on a conventional hemocytometer. The algorithm has been designed, implemented and tested on test images that vary in image quality. The proposed algorithm uses a recursively segmented, median filtered and a boosted Prewitt gradient mask to generate a boundary box that encloses all the identified cells. Intensity profile plots acting as signature plots further assist in classifying a single isolated cell from a cell cluster. Processed results compared manually by a biological expert resulted in an accuracy of 95 % for even low quality images with a computational time ranging between 8-12sec. Improved performance from the proposed algorithm could be observed when compared with other conventional image analysis tools.
本文提出了一种高通量细胞计数和聚类分类算法,用于在常规血细胞计上量化白血病细胞系的种群统计。该算法已经设计、实现并在不同图像质量的测试图像上进行了测试。该算法使用递归分割、中值滤波和增强的Prewitt梯度掩码生成一个包围所有已识别细胞的边界框。作为特征图的强度分布图进一步有助于从细胞簇中对单个孤立细胞进行分类。处理后的结果由生物专家手动比较,即使是低质量的图像,计算时间在8-12秒之间,准确率也达到95%。与其他传统图像分析工具相比,该算法的性能有所提高。
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引用次数: 13
Impulse Radio technology for Biomedical applications 生物医学应用脉冲无线电技术
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463310
T. Lande, H. A. Hjortland
Improving quality of service in wireless communication links is of vital importance in biomedical applications. Current wireless technology is far from satisfactory conveying vital signs in personalized healthcare. Nevertheless current technology like Bluetooth and ZigBee is explored even for critical monitoring of patients, both in hospital environments and homecare. In this paper we are exploring impulse radio as a feasible technology for health monitoring. By exploring advanced technology and novel architectures, improved quality of service may be granted. Additional interesting biomedical functionality of impulse radio is detached body sensors (short-range medical radar).
提高无线通信链路的服务质量在生物医学应用中至关重要。目前的无线技术还不能满足个性化医疗中生命体征的传输。然而,目前的技术,如蓝牙和ZigBee,甚至是在医院环境和家庭护理中对病人进行关键监控的探索。本文探讨脉冲无线电作为一种可行的健康监测技术。通过探索先进的技术和新颖的架构,可以提高服务质量。脉冲无线电的另一个有趣的生物医学功能是分离的身体传感器(短程医疗雷达)。
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引用次数: 7
Low-Power VLSI Architecture for Neural Data Compression Using Vocabulary-based Approach 基于词汇表方法的神经数据压缩低功耗VLSI架构
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463327
S. Narasimhan, Yu Zhou, H. Chiel, S. Bhunia
Modern-day bio-implantable chips for neural prostheses cannot monitor a large number of electrodes at the same time since they suffer from excessively high data rates. Hence, it is imperative to design area and power-efficient digital circuits for appropriate conditioning of the recorded neural signal in order to remain within the bandwidth constraint. Previously, we have proposed an algorithm for neural data compression, which incorporates the concept of creating and maintaining a dynamic vocabulary of neural spike waveforms represented as wavelet transform coefficients. In this paper, we propose an appropriate architecture for low-power and area-efficient VLSI implementation of the scheme. Based on simulation results, the hardware consumes 3.55 muW and 0.36 mW power using 0.18 mum CMOS technology for 1-channel and 100-channel neural recording applications, respectively.
现代用于神经假体的生物植入芯片由于数据速率过高,无法同时监测大量电极。因此,必须设计面积和功率效率高的数字电路,以适当地调节所记录的神经信号,以保持在带宽限制内。之前,我们提出了一种神经数据压缩算法,该算法包含了创建和维护以小波变换系数表示的神经尖峰波形动态词汇表的概念。在本文中,我们提出了一种适合低功耗和面积高效的VLSI实现方案的架构。基于仿真结果,采用0.18 μ m CMOS技术的硬件功耗分别为3.55 μ w和0.36 μ w,用于1通道和100通道神经记录应用。
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引用次数: 7
Wireless Data Links for Biomedical Implants: Current Research and Future Directions 生物医学植入物的无线数据链路:当前研究和未来方向
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463297
C. Charles
This paper outlines the requirements for high-rate implantable data links as would be used in applications such as visual prostheses. Methods used in current research are categorized and recently reported implementations are discussed and compared. The most significant shortcoming of current implementations is in their data rates which are limited to several Mb/s, while rates of several tens of Mb/s are envisioned to be necessary for a functional visual prosthesis. Several promising methods for achieving increased data rates are discussed, including ultra-wide band signaling, infrared transmission, and body conduction techniques.
本文概述了高速率可植入数据链的要求,这些数据链将用于视觉假肢等应用。对当前研究中使用的方法进行了分类,并对最近报道的实现进行了讨论和比较。当前实现的最大缺点是数据速率限制在几Mb/s,而几十Mb/s的速率被认为是功能性视觉假体所必需的。讨论了几种有希望实现增加数据速率的方法,包括超宽带信号,红外传输和体传导技术。
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引用次数: 20
Fully Integrated Impedance Spectroscopy Systems for Biochemical Sensor Array 用于生化传感器阵列的全集成阻抗光谱系统
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463299
Chao Yang, D. Rairigh, Andrew J. Mason
With rapid progress in the miniaturization of biosensors, array microsystems utilizing impedance spectroscopy (IS) are of emerging interest. Focused on the electronics portion of such IS microsystems, this paper analyzes FFT-based and frequency response analyzer (FRA)-based approaches and compares them for hardware efficiency in array applications. For the chosen FRA-based approach, two possible systems are described and their circuit-level realizations are presented, one targeting high accuracy applications and the other prioritizing rapid interrogation.
随着生物传感器小型化的快速发展,利用阻抗谱技术的阵列微系统引起了人们的广泛关注。本文着重于这些IS微系统的电子部分,分析了基于fft和基于频率响应分析仪(FRA)的方法,并比较了它们在阵列应用中的硬件效率。对于所选择的基于fra的方法,描述了两种可能的系统并给出了它们的电路级实现,一种针对高精度应用,另一种优先考虑快速审讯。
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引用次数: 16
On the Swept-threshold Sampling in UWB Medical Radar 超宽带医疗雷达扫描阈值采样研究
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463308
Lars Erik Solberg, I. Balasingham
The non-invasive techniques to measure vital signs have received much attention lately. They exhibit several advantages compared to the traditional invasive techniques. One such technique can be based on radar principles. In this paper we scrutinize the statistical properties of a medical radar developed on a single CMOS chip, which operates in the ultra wideband from 3.1 GHz to 10.6 GHz. A key part of the chip is based on a new technique for sampling at very high frequencies called swept- threshold sampling. This is based on multiple pulse emissions, accumulation and range-gating. We derive expressions for the bias and variance of swept-threshold sampling and show that the bias is a strong function of noise power and input value, but independent of the swept-threshold parameters for a fixed input range. The variance is shown to be proportional to the quantization step size and standard deviation of the noise process. Finally, simulation results are provided as proof of concept, and they show that the derived theoretical equations for bias and mean square error are valid.
近年来,无创生命体征测量技术受到了广泛的关注。与传统的侵入性技术相比,它们有几个优点。一种这样的技术可以基于雷达原理。在本文中,我们仔细研究了在单一CMOS芯片上开发的医疗雷达的统计特性,该芯片工作在3.1 GHz至10.6 GHz的超宽带范围内。该芯片的关键部分是基于一种新的高频采样技术,称为扫频阈值采样。这是基于多脉冲发射,积累和距离门控。我们推导了扫描阈值采样的偏置和方差的表达式,并表明偏置是噪声功率和输入值的强函数,但在固定的输入范围内与扫描阈值参数无关。方差显示为与量化步长和噪声过程的标准差成正比。最后,给出了仿真结果作为概念验证,结果表明推导出的偏差和均方误差的理论方程是有效的。
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引用次数: 3
A Mixed-Signal Multi-Chip Neural Recording Interface with Bandwidth Reduction 一种带宽降低的混合信号多芯片神经记录接口
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463306
B. Gosselin, A. E. Ayoub, M. Sawan
We present the design of a multi-chip neural interface intended for multi-channel neural recording. The design features a mixed-signal part that handles neural signal conditioning, digitization and time-division multiplexing, and a digital part that provides control, bandwidth reduction, and serial communications towards a host interface. The two CMOS 0.18-mum fabricated embedded circuits that implement both parts are directly mounted on the back of a medical-grade stainless steel microelectrodes array and wire-bonded to its post-processed base. The presented neural interface integrates 16 channels for validation; however, the proposed approach is scalable to larger channel counts. In fact, it is suitable to implement microsystems including several hundreds of recording channels. The performance of the implemented multi-channel interface was validated with real neural waveforms.
我们提出了一种用于多通道神经记录的多芯片神经接口的设计。该设计具有处理神经信号调理、数字化和时分多路复用的混合信号部分,以及提供控制、带宽减少和对主机接口的串行通信的数字部分。实现这两个部分的两个CMOS 0.18 mum制造嵌入式电路直接安装在医疗级不锈钢微电极阵列的背面,并通过导线粘合到其后处理底座上。该神经接口集成了16个通道进行验证;然而,所提出的方法可扩展到更大的信道计数。实际上,它适用于实现包含数百个记录通道的微系统。用真实神经网络波形验证了所实现的多通道接口的性能。
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引用次数: 16
An Ultra-low-Power Quadrature PLL in 130nm CMOS for Impulse Radio Receivers 脉冲无线电接收机用130nm CMOS超低功耗正交锁相环
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463309
N. V. Helleputte, G. Gielen, Kasteelpark Arenberg
This paper discusses an architecture for an integrated ultra-low power impulse radio receiver for low data rate applications such as biomedical sensor networks. Choosing a proper system architecture allows to implement a receiver with relaxed specifications for the typical building blocks which results in a low-power implementation. Furthermore a design in 130 nm CMOS of a fully integrated ultra-low power PLL, a critical block of such receivers, is presented. The PLL serves a double purpose. It acts as the master clock generator for the receiver and it is also used to generate a template waveform for pulse reception. The latter requires the PLL to have quadrature outputs since the receiver uses I/Q reception. Because rather relaxed specifications in terms of phase-noise are required, a differential ring VCO with an even amount of stages is a suitable topology. The VCO has a measured center frequency of 568 MHz and a tuning range of 23%. It achieves a phase-noise of -91 dBc/Hz @ 1 MHz offset. The PLL employs a divide-by-8 and locks to an externally applied 75 MHz clock. Measurements show a total power consumption less than 200 muW with an rms jitter of 24 ps on an output clock of 600 MHz.
本文讨论了用于生物医学传感器网络等低数据速率应用的集成超低功率脉冲无线电接收机的体系结构。选择合适的系统架构可以实现具有典型构建块宽松规格的接收器,从而实现低功耗实现。此外,本文还设计了一种完全集成的超低功耗锁相环,该锁相环是这种接收器的关键模块。锁相环有双重用途。它作为接收机的主时钟发生器,也用于生成脉冲接收的模板波形。后者要求锁相环具有正交输出,因为接收器使用I/Q接收。因为在相位噪声方面要求相当宽松的规格,具有均匀级数的差动环压控振荡器是一种合适的拓扑结构。VCO的测量中心频率为568 MHz,调谐范围为23%。它实现了-91 dBc/Hz的相位噪声@ 1 MHz偏移。锁相环采用除以8,并锁定到外部应用的75 MHz时钟。测量结果表明,在600 MHz的输出时钟上,总功耗小于200 muW,有效值抖动为24 ps。
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引用次数: 14
期刊
2007 IEEE Biomedical Circuits and Systems Conference
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