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2007 IEEE Biomedical Circuits and Systems Conference最新文献

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A Handheld Fluorometer for UV Excitable Fluorescence Assays 一种用于紫外激发荧光测定的手持式荧光计
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463321
N. Nelson, S. Prakash, D. Sander, M. Dandin, A. Sarje, Honghao Ji, P. Abshire
We report the development of a handheld fluorometer for UV excitable fluorescence assays. The handheld detector serves as a demonstration platform for an integrated fluorescence sensor and comprises a CMOS detector coated with a polymer based optical filter and placed in close proximity to a UV LED which is used as an excitation source. The sensor function has been validated for metabolic activity and cytotoxicity assays. The fluorometer was able to determine NADH concentration as low as 17 muM and was able to track NADH production in live yeast cells over time and as the yeast cell concentration varied. The sensor was also used to discriminate the viability of human intestinal adenocarcinoma cells (Caco-2 cell line) using a live/dead stain after exposure to toxic and benign nanoparticles. The integrated fluorescence sensor is suitable for microscale fluorescence detection in lab-on-a-chip applications.
我们报告了一种手持式荧光仪的发展,用于紫外激发荧光测定。手持式探测器作为集成荧光传感器的演示平台,包括一个涂有聚合物光学滤光片的CMOS探测器,并放置在靠近用作激发源的UV LED的位置。该传感器功能已在代谢活性和细胞毒性试验中得到验证。荧光仪能够测定低至17 muM的NADH浓度,并能够随着时间的推移和酵母细胞浓度的变化跟踪活酵母细胞中NADH的产生。该传感器还被用于鉴别暴露于有毒和良性纳米颗粒后的人肠腺癌细胞(Caco-2细胞系)的活/死染色。该集成荧光传感器适用于芯片实验室应用中的微尺度荧光检测。
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引用次数: 5
A Scalable Architecture for Event-Based Cross-Correlation 基于事件的相互关联的可伸缩架构
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463314
J. Tapson, C. Jin, A. van Schaik
We present an architecture for a bio-inspired circuit that implements a wide-range cross-correlation. The circuit implements a stochastic approximation to mathematical cross-correlation. The basic circuit element is a noise-driven oscillator consisting of an integrator, a Schmitt inverter, and a switch which switches between the two signals to be cross-correlated. These elements can be developed into an NxN array which extends the cross-correlation range and improves the speed and accuracy of the approximation.
我们提出了一种实现大范围互相关的生物启发电路的架构。该电路实现了对数学互相关的随机逼近。基本电路元件是一个噪声驱动振荡器,由一个积分器、一个施密特逆变器和一个开关组成,该开关在两个要交叉相关的信号之间切换。这些元素可以发展成一个NxN阵列,扩展互相关范围,提高近似的速度和精度。
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引用次数: 4
A Wearable Inertial Sensing Technology for Clinical Assessment of Tremor 一种用于临床评估震颤的可穿戴惯性传感技术
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463296
H. Powell, M. Hanson, J. Lach
TEMPO (Technology-Enabled Medical Precision Observation) 1.0 is a novel, first-generation, wearable data collection and analysis platform for assessment of a variety of human movement disorders, including tremor. It enables quantitative, objective, and continuous measurement of movement with minimal invasiveness and inconvenience to the patient and clinician, respectively. This system meets requirements for wearability, data storage, sampling rate, number of sensors, interface methods, and form factor, which are necessary for applications on person. In addition to the design and development of a basic data acquisition device, various circuits and systems were engineered to interface wearable, triaxial MEMS inertial sensors. Furthermore, custom data analysis software that processes datasets collected from the device and sensors, was created, and has demonstrated clinical utility in the analysis of tremor. Data processing techniques include a unique filtering scheme and a novel application of cross-correlation. The analysis was conducted pre- and post-operatively, in conjunction with the University of Virginia's Department of Neurosurgery, for a study of deep brain stimulation efficacy. This paper presents the engineering of and experimental results obtained with TEMPO 1.0 technology in the clinical assessment of tremor.
TEMPO (Technology-Enabled Medical Precision Observation) 1.0是一种全新的第一代可穿戴数据收集和分析平台,用于评估包括震颤在内的各种人类运动障碍。它能够定量、客观和连续地测量运动,对患者和临床医生分别具有最小的侵入性和不便。该系统在可穿戴性、数据存储、采样率、传感器数量、接口方式、外形尺寸等方面满足了人体应用的要求。除了设计和开发基本的数据采集设备外,还设计了各种电路和系统来连接可穿戴的三轴MEMS惯性传感器。此外,定制数据分析软件,处理从设备和传感器收集的数据集,被创建,并已证明在临床应用分析震颤。数据处理技术包括独特的滤波方案和互相关的新应用。这项分析是与弗吉尼亚大学神经外科联合进行的,目的是研究深部脑刺激的效果。本文介绍了TEMPO 1.0技术在震颤临床评价中的工程原理和实验结果。
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引用次数: 20
A Low Power Fully Programmable 1MHz Resolution 2.4GHz CMOS PLL Frequency Synthesizer 低功耗全可编程1MHz分辨率2.4GHz CMOS锁相环频率合成器
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463340
M. Vamshi Krishna, J. Xie, W. M. Lim, M. Do, K. Yeo, C. Boon
This paper presents a low power, high resolution 2.4 GHz CMOS frequency synthesizer for low power wireless LAN applications. The PLL frequency synthesizer consists of a fully programmable frequency divider with a resolution of 1 MHz in the range of 2.4 GHz-2.484 GHz.The measured results showed that the programmable divider consumes 946 uA and Quadrature VCO consumes 1.57 mA and produces output swing of 650-700 mVpp. The complete synthesizer is designed using the Chartered RF 0.18 um process and synthesizer consumes 2.7 mA.
提出了一种低功耗、高分辨率的2.4 GHz CMOS频率合成器,适用于低功耗无线局域网。锁相环频率合成器由一个完全可编程分频器组成,在2.4 GHz-2.484 GHz范围内分辨率为1 MHz。测量结果表明,可编程分频器的功耗为946 uA,正交压控振荡器的功耗为1.57 mA,输出摆幅为650-700 mVpp。完整的合成器采用特许RF 0.18 um工艺设计,合成器消耗2.7 mA。
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引用次数: 15
High-Quality Image Compression for Gastrointestinal Endoscope 胃肠内窥镜的高质量图像压缩
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463330
Lan-Rong Dung, Tsung-Hsi Chiang
This paper proposes an efficient framework of high-quality image compression method for upper Gastrointestinal tract endoscopy images. The proposed DEWC coding method saves traditional image preprocessing computations, such as demosaicking and color-space transformation, and directly utilizes raw image data acquired from CMOS sensor. R, G and B band image are then separately encoded by wavelet-based SPECK coding. In a cardinal GI tract environment, the spatial frequency distribution of red component is lower than green or blue, and green component is relatively high while compared to blue and red components. DEWC coding saves more bits on red band while allocating more bits on green and blue bands. Therefore, under a fixed compression ratio, such non-uniform bit-rate allocation may earn a better image quality. To measure quality-loss in non-uniform bit-rate allocation, a quality quantified measurement called color-distortion based on CIE94 color-difference formula is also proposed. By using analytical result of color-distortion in bit-rate and bit-rate-difference analysis, an optimal/suboptimal bit-rate allocation scheme can be found by solving linear equations derived from the relationship of color-distortion and bit-rate-difference. When comparing to general JPEG2000 compression standard, the experimental result shows that proposed DEWC coding has a better image quality in color-distortion measurement and more efficient performance in execution time.
提出了一种高效的上消化道内窥镜图像高质量压缩方法框架。本文提出的DEWC编码方法省去了传统的图像预处理计算,如去马赛克和色彩空间变换,直接利用从CMOS传感器获取的原始图像数据。然后用基于小波的SPECK编码分别对R、G、B波段图像进行编码。在基数胃肠道环境中,红色分量的空间频率分布低于绿色或蓝色,而绿色分量相对于蓝色和红色分量相对较高。DEWC编码在红色频带上节省更多的比特,在绿色和蓝色频带上分配更多的比特。因此,在固定的压缩比下,这种不均匀的比特率分配可以获得更好的图像质量。为了测量非均匀比特率分配中的质量损失,提出了一种基于CIE94色差公式的质量量化测量方法——颜色失真。利用码率和码率差分析中颜色失真的分析结果,通过求解由颜色失真和码率差关系导出的线性方程,找到最优/次优码率分配方案。实验结果表明,与通用的JPEG2000压缩标准相比,本文提出的DEWC编码在色彩失真测量方面具有更好的图像质量,在执行时间上具有更高的性能。
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引用次数: 0
A Bidirectional Wireless Link for Neural Prostheses that Minimizes Implanted Power Consumption 一种用于神经假体的双向无线链路,可将植入的能量消耗降至最低
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463305
S. Mandal, R. Sarpeshkar
We describe a bidirectional impedance-modulation wireless data link for implanted neural prostheses. The link uses near-field inductive coupling between the implanted system and an external transceiver. It is designed to minimize power consumption in the implanted system and support high data rates in the uplink direction (from the implanted to the external system). Experimental results demonstrate data transfer rates up to 5.8 Mbps in the uplink direction and 300 kbps in the downlink direction at a link distance of 2 cm. The link dissipates 100 muW in the implanted system and 2.5 mW in the external system, making it among the most power-efficient inductive data links reported.
我们描述了一种用于植入式神经假体的双向阻抗调制无线数据链路。该链路在植入系统和外部收发器之间使用近场感应耦合。它的设计是为了最小化植入系统的功耗,并支持上行方向(从植入到外部系统)的高数据速率。实验结果表明,在2 cm的链路距离下,上行方向的数据传输速率可达5.8 Mbps,下行方向的数据传输速率可达300 kbps。该链路在植入系统中耗散100毫瓦,在外部系统中耗散2.5毫瓦,使其成为报告中最节能的感应数据链路之一。
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引用次数: 18
Reliable Computation in Noisy Backgrounds Using Real-Time Neuromorphic Hardware 基于实时神经形态硬件的噪声背景下的可靠计算
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463311
Hsi-Ping Wang, E. Chicca, G. Indiveri, T. Sejnowski
Spike-time based coding of neural information, in contrast to rate coding, requires that neurons reliably and precisely fire spikes in response to repeated identical inputs, despite a high degree of noise from stochastic synaptic firing and extraneous background inputs. We investigated the degree of reliability and precision achievable in various noisy background conditions using real-time neuromorphic VLSI hardware which models integrate-and-fire spiking neurons and dynamic synapses. To do so, we varied two properties of the inputs to a single neuron, synaptic weight and synchrony magnitude (number of synchronously firing pre-synaptic neurons). Thanks to the realtime response properties of the VLSI system we could carry out extensive exploration of the parameter space, and measure the neurons firing rate and reliability in real-time. Reliability of output spiking was primarily influenced by the amount of synchronicity of synaptic input, rather than the synaptic weight of those synapses. These results highlight possible regimes in which real-time neuromorphic systems might be better able to reliably compute with spikes despite noisy input.
与频率编码相比,基于峰值时间的神经信息编码要求神经元可靠而精确地响应重复的相同输入,尽管随机突触放电和外来背景输入的噪声很高。我们研究了在各种噪声背景条件下,使用实时神经形态VLSI硬件实现的可靠性和精度,该硬件模拟了集成和发射尖峰神经元和动态突触。为此,我们改变了单个神经元输入的两个属性,突触权重和同步幅度(同步发射突触前神经元的数量)。由于超大规模集成电路系统的实时响应特性,我们可以对参数空间进行广泛的探索,并实时测量神经元的放电速率和可靠性。输出峰值的可靠性主要受突触输入的同步性数量的影响,而不是受这些突触的突触权重的影响。这些结果突出了实时神经形态系统在有噪声输入的情况下能够更好地可靠地计算峰值的可能机制。
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引用次数: 7
FPGA Based Silicon Spiking Neural Array 基于FPGA的硅脉冲神经阵列
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463312
A. Cassidy, S. Denham, P. Kanold, A. Andreou
Rapid design time, low cost, flexibility, digital precision, and stability are characteristics that favor FPGAs as a promising alternative to analog VLSI based approaches for designing neuromorphic systems. High computational power as well as low size, weight, and power (SWAP) are advantages that FPGAs demonstrate over software based neuromorphic systems. We present an FPGA based array of Leaky-Integrate and Fire (LIF) artificial neurons. Using this array, we demonstrate three neural computational experiments: auditory Spatio-Temporal Receptive Fields (STRFs), a neural parameter optimizing algorithm, and an implementation of the Spike Time Dependant Plasticity (STDP) learning rule.
快速的设计时间、低成本、灵活性、数字精度和稳定性是fpga作为基于模拟VLSI的神经形态系统设计方法的有前途的替代品的特点。与基于软件的神经形态系统相比,高计算能力以及低尺寸、重量和功耗(SWAP)是fpga的优势。我们提出了一种基于FPGA的泄漏集成和火灾(LIF)人工神经元阵列。利用该阵列,我们演示了三个神经计算实验:听觉时空感受场(strf)、神经参数优化算法和峰值时间依赖可塑性(STDP)学习规则的实现。
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引用次数: 65
A Portable MIDI Controller Using EMG-Based Individual Finger Motion Classification 一种便携式MIDI控制器,使用基于肌电图的单个手指运动分类
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463328
F. Bitar, N. Madi, E. Ramly, M. Saghir, F. Karameh
Classifying the motion of the five fingers of the hand using non-invasive bio-signal readings from the forearm is still an unsolved research challenge. Its solution is relevant to hands-free remote control devices, on-stage live performances, consumer entertainment, the video game industry, and most importantly the design of hand prosthetics for amputees. This paper proposes a solution that uses the continuous wavelet transform (CWT) decompositions of electromyography (EMG) signals from the forearm muscles, and Support Vector Machines (SVM) classification. The resulting design is a low cost, low power and low complexity portable embedded system that is strapped to the arm, where it collects EMG signals, classifies them in real-time, and sends the resulting class labels via Bluetooth to a remote interface. These labels are then converted into musical instrument digital interface (MIDI) commands that can be used to control any MIDI-controllable device. While the design is still at the prototype stage at best, it provides a proof-of-concept of non-invasive finger motion classification solely based on EMG readings from the forearm muscles. Experimental simulation of the expected system achieved 91% accuracy.
利用前臂的非侵入性生物信号读数对手的五个手指的运动进行分类仍然是一个未解决的研究挑战。它的解决方案适用于免提遥控设备、舞台现场表演、消费娱乐、视频游戏行业,最重要的是,适用于截肢者的假肢设计。本文提出了一种利用连续小波变换(CWT)对前臂肌肉肌电信号进行分解和支持向量机(SVM)分类的解决方案。最终的设计是一个低成本、低功耗、低复杂性的便携式嵌入式系统,它被绑在手臂上,在那里它收集肌电信号,实时分类,并通过蓝牙将结果分类标签发送到远程接口。然后将这些标签转换为乐器数字接口(MIDI)命令,可用于控制任何MIDI可控设备。虽然该设计充其量还处于原型阶段,但它提供了一个概念验证,即仅根据前臂肌肉的肌电图读数进行非侵入性手指运动分类。预期系统的实验仿真精度达到91%。
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引用次数: 6
Optimization criteria in the design of medical UWB radars in compliance with the regulatory masks 医用超宽频雷达设计的优化准则是否符合监管要求
Pub Date : 2007-11-01 DOI: 10.1109/BIOCAS.2007.4463307
E. Staderini, G. Varotto
A general method is described to select an optimal set of parameters to design a pulse radar system [1] for heart motion detection [2,3]- Relating to the tracking of heart wall movement, the required acquisition time and sampling frequency are determined and subsequently pulse repetition frequency, pulse echo averaging and pulse power are obtained under regulatory mask power limitations defined for UWB emissions [4,5]. Although essentially theoretical and sometimes quite trivial, the reported model may be used as a reference for the parameters setting in the design of UWB radars for the acquisition of the temporal motion signal of internal body organs [6,7].
本文描述了一种选择一组最优参数来设计用于心脏运动检测的脉冲雷达系统的一般方法[1][2,3]。与心脏壁运动跟踪有关,确定所需的采集时间和采样频率,然后在UWB发射定义的调节掩模功率限制下获得脉冲重复频率、脉冲回波平均和脉冲功率[4,5]。虽然该模型本质上是理论性的,有时甚至相当琐碎,但该模型可作为超宽带雷达设计参数设置的参考,用于获取人体内部器官的时间运动信号[6,7]。
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引用次数: 14
期刊
2007 IEEE Biomedical Circuits and Systems Conference
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