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Consideraciones éticas, aspectos geriátricos y de cuidados paliativos relativos a la asistencia clínica en situación de crisis sanitaria. Hospital Clínico Universidad de Chile (marzo 2020) 与健康危机情况下的临床护理有关的伦理考虑、老年病学方面和姑息治疗。智利大学临床医院(2020年3月)
Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69903
Domingo Castillo S., R. Cornejo R, Nivia Estuardo A., Jaime Hidalgo F., Alejandra Palma B., S. Valenzuela P.
Este documento es una guía general para técnicos y profesionales de la salud. Su contenido ha sido adecuado al contexto asistencial del Hospital Clínico Universidad de Chile (HCUCH) e incluye especificaciones atingentes a la pandemia Covid-19 que estamos viviendo a nivel mundial. Este documento no pretende ni debe ser considerado un sustituto a consultas al Comité de Ética Asistencial o a cualquier otra entidad o profesional que se requiera para entregar una atención óptima a los pacientes y familias que concurran a nuestra institución. El contenido de este documento podrá ser modificado en la medida en que el desarrollo de los acontecimientos sanitarios genere la necesidad de actualizar o complementar la información.Debemos enfatizar la necesidad de agotar todos los esfuerzos por maximizar las medidas de seguridad y minimizar el riesgo de Covid-19 de pacientes, familiares y funcionarios de la salud en todo momento.
本文件是技术人员和卫生专业人员的一般指南。它的内容适合智利大学临床医院(HCUCH)的护理背景,包括与我们正在全球经历的Covid-19大流行有关的规范。本文件不打算也不应被视为替代医疗道德委员会或任何其他实体或专业人员的咨询,这些实体或专业人员需要为来到我们机构的患者和家属提供最佳护理。如果卫生事件的发展需要更新或补充信息,本文件的内容可予以修改。我们必须强调,必须尽一切努力,在任何时候最大限度地采取安全措施,最大限度地降低患者、家属和卫生官员的Covid-19风险。
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引用次数: 0
Enfrentamiento a una masa cervical no tiroidea en Atención Primaria 在初级保健中处理非甲状腺宫颈肿块
Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69840
T. González A., L. Fuenzalida M., P. Gac E., F. Rodríguez M., P. Cabané T., D. Rappoport W.
The clinical approach to non-thyroid cervical masses in primary care has always been considered a diagnostic challenge. In the absence of specific diagnostic methods, the general practitioner must rely on clinic and general tests in order to achieve a suspected diagnosis and timely referral. On initial approach to cervical masses, one must first analyze each case according to patient age, associating an exhaustive anamnesis focused on the growth pattern and aggregate symptoms, along with a physical examination focused on signs of malignancy. Once completed, the etiology of the mass can be classified as probable congenital, inflammatory or tumoral origin. And also try to determine localization, temporality and discriminate between benign and malignant causes. Once the clinical interrogation has been completed, basic complementary tests and/or directed test according to suspicion can be requested. The foregoing allows the primary care physician a proper referral to specialist and/or initiation of appropriate treatment.
临床途径非甲状腺宫颈肿块在初级保健一直被认为是一个诊断的挑战。在缺乏具体诊断方法的情况下,全科医生必须依靠临床和一般检查来实现疑似诊断和及时转诊。在对宫颈肿块进行初步检查时,必须首先根据患者的年龄对每个病例进行分析,并结合以生长模式和总体症状为重点的详尽记忆,以及以恶性肿瘤征象为重点的体格检查。一旦完成,肿块的病因可以分类为可能的先天性,炎性或肿瘤起源。并试图确定局部,时间和区分良性和恶性的原因。临床审讯完成后,可要求根据怀疑情况进行基本补充检查和/或直接检查。上述允许初级保健医生适当转诊到专科和/或开始适当的治疗。
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引用次数: 0
Caracterización clínica y angiográfica según sexo de pacientes con síndrome coronario agudo sin supradesnivel del segmento ST 无ST段抬高的急性冠状动脉综合征患者的临床和血管造影特征
Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69927
H. Ugalde P., Pablo Romero A., Ignacio Cifuentes R.
Ischemic Heart Disease is the leading cause of death and of potential years of life lost in Chile. The most frequent acute presentation of this group of pathologies is the Acute Coronary Syndrome (ACS) without ST segment elevation. According to the literature, there is a proportion of patients with non-ST elevated ACS in which coronary angiography reveals a mild coronary lesion or even shows no detectable lesion at all. This scenario is more common in women than in men. Compared with men, women with non-ST elevated ACS are older than men and more frequently have hypertension. Furthermore, women are less likely to have previous cardiac diseases, and are less common to present serum troponin rise at admission. In Chile, there are no previous studies about the differences between sexes in this disease. The objective of this study is to determine if there are major differences between sexes in aspects like clinical and angiographic findings in patients with non-ST elevated ACS. The study used a database of 1900 consecutive patients who were submitted for coronary angiography and had been previously diagnosticated with non-ST elevated ACS, between the years 2001-2017. Clinical assessment, laboratory and angiographic results were collected and analyzed to establish major differences considering p
在智利,缺血性心脏病是导致死亡和潜在寿命损失的主要原因。这组病理最常见的急性表现是无ST段抬高的急性冠脉综合征(ACS)。根据文献,有一部分非st段升高的ACS患者冠脉造影显示冠脉有轻微病变,甚至没有可检测到的病变。这种情况在女性中比在男性中更常见。与男性相比,女性非st段升高的ACS患者年龄大于男性,并且更容易出现高血压。此外,女性既往患心脏病的可能性更小,入院时血清肌钙蛋白升高的情况也更少。在智利,以前没有关于这种疾病的性别差异的研究。本研究的目的是确定非st段升高的ACS患者在临床和血管造影表现等方面是否存在主要的性别差异。该研究使用了一个数据库,该数据库包含1900名连续患者,这些患者在2001年至2017年期间接受了冠状动脉造影,之前曾被诊断为非st段升高的ACS。收集并分析临床评估、实验室和血管造影结果,以确定考虑p
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引用次数: 0
Caracterización de indicadores de detección de glaucoma con los equipos OCT Spectralis y campímetro Humphrey II en pacientes altos miopes y altos miopes glaucomatosos del Hospital Clínico Universidad de Chile 智利大学临床医院中高近视和高近视青光眼患者中OCT光谱设备和Humphrey II campmeter青光眼检测指标的特征
Pub Date : 2019-07-01 DOI: 10.5354/2735-7996.2019.70044
Felipe Rojas B., Mauricio Aguilar V., Karl Meza M., Catalina Pinto C., Paula Verdugo H.
Purpose: Characterize and describe glaucoma index parameters of the results of visual exams, Optical Coherence Tomography and Visual Field, in high myopic subjects with and without the pathology. Method: Cross sectional and observational study of 39 eyes, 15 high myopic with glaucoma y 24 high myopic without it. Visual Field (VF) were performed, where the global index between both groups were analyzed; Mean Deviation (MD), Model Standard Deviation (MSD) and Visual Field Index (VFI), beside Optical Coherence Tomography (OCT), in which the thickness of the ganglion cells layer (GCL) inside 3 central mm was compared. Results: The results were satisfactory, demonstrating different characteristics between the high myopic group with glaucoma and without it, both in VF and OCT exams. It was obtained in the VF analysis difference in average MD of -4,92 dB + 3,71 (p0,05) and VFI with Friedman Test 10,29 (p>0,05). The statistical OCT analysis, when comparing GCL, observed that the Temporary sector (T) had a statistically significant decrease (p
目的:描述高度近视患者的视力检查、光学相干断层扫描和视野检查结果的青光眼指数参数。方法:对39只眼进行横断面观察研究,高度近视伴青光眼15只,高度近视不伴青光眼24只。进行视野(VF),分析两组之间的全局指数;光学相干断层扫描(OCT)的平均偏差(MD)、模型标准差(MSD)和视野指数(VFI),比较3中心mm内神经节细胞层(GCL)的厚度。结果:高度近视伴青光眼组与非高度近视青光眼组在VF和OCT检查中表现出不同的特征,结果令人满意。VF分析得到平均MD为-4,92 dB + 3,71 (p0,05)与VFI弗里德曼检验10,29 (p> 0.05)的差异。统计OCT分析,在比较GCL时,观察到临时区(T)有统计学上显著的减少(p
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引用次数: 0
Infecciones profundas del cuello 颈部深部感染
Pub Date : 2019-07-01 DOI: 10.5354/2735-7996.2019.70052
Rodrigo Jiménez Y., D. Rappoport W., E. Ramírez, P. Gac E., F. Rodríguez M., P. Cabané T.
Deep neck infections (DNIs) are special entities among infectious diseases for their versatility and potential for severe complications. Complex head and neck anatomy often makes early recognition of DNIs challenging, and a high index of suspicion is necessary to avoid any delay in treatment. The diagnosis is made by clinical history, physical examination findings and imaging studies. The treatment consists in securing the airway, intravenous antibiotics and surgical drainage, when needed. To make decisions the surgeon must understand the anatomy of the region, the etiology of infection, appropriate diagnostic tools, and medical and surgical management. This article provides a review of these pertinent topics.
深颈部感染(DNIs)因其多功能性和潜在的严重并发症而成为传染病中的特殊实体。复杂的头颈部解剖结构往往使早期识别DNIs具有挑战性,高度怀疑是必要的,以避免任何延误治疗。诊断依据临床病史、体格检查和影像学检查。治疗包括固定气道、静脉注射抗生素和必要时的手术引流。为了做出决定,外科医生必须了解该区域的解剖结构,感染的病因,适当的诊断工具,以及医疗和手术管理。本文对这些相关主题进行了回顾。
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引用次数: 0
Síndrome de hiperémesis por cannabinoides: caso clínico 大麻素充血综合征:临床病例
Pub Date : 2019-07-01 DOI: 10.5354/2735-7996.2019.70048
Daniela Benavides A., Daniela Valle S., Carlos Ibáñez P.
Background. The cannabinoid hyperemesis syndrome (CHS) was first described in 2004. It is considered as a functional gastrointestinal syndrome characterized by the presence of nausea, severe and cyclic morning vomiting, epigastric abdominal pain, hot water bathing for symptom relief, in patients that use cannabis regularly and has a resolution of the syndrome after cessation of cannabis consumption. Clinical Case. Report of a 29 year old male, with daily consumption of cannabis, with history of intense epigastric abdominal pain and recurrent vomiting that partially responded to the use of antispasmodics. After 4 visits to the emergency department he was hospitalized for study and treatment. Laboratory and image exploration are carried out without positive results for organic disease. Therefore, a functional gastrointestinal syndrome is thought, and a cannabinoid hyperemesis syndrome was suspected. A psychiatric evaluation is carried out, diagnosing a cannabis use disorder. Discussion and conclusion. CHS is a syndrome that has been described recently and is not usually considered as a differential diagnosis for patients with hyperemesis. However, the current high prevalence of cannabis consumption, will probably lead to a more frequent presentation of the syndrome at different health providers. Therefore, it is important to diffuse and update the knowledge about this syndrome to recognize it and develop a timely treatment, avoiding medical complications from invasive exploratory methods and the use of unnecessary resources.
背景。大麻素剧吐综合征(CHS)于2004年首次被描述。它被认为是一种功能性胃肠综合征,其特征是经常使用大麻的患者出现恶心、严重和周期性晨吐、上腹部疼痛、热水浴以缓解症状,并且在停止吸食大麻后症状得到缓解。临床病例。报告一名29岁男性,每日吸食大麻,有强烈的上腹部疼痛和反复呕吐史,部分对使用抗痉挛药物有反应。到急诊科就诊4次后,住院学习治疗。对器质性疾病进行实验室和图像探查,未见阳性结果。因此,功能性胃肠综合征被认为是,大麻素呕吐综合征被怀疑。进行了精神评估,诊断为大麻使用障碍。讨论与结论。CHS是一种最近被描述的综合征,通常不被认为是呕吐患者的鉴别诊断。然而,目前大麻消费的高流行率可能会导致更频繁地在不同的保健提供者处出现这种综合症。因此,传播和更新有关该综合征的知识,及时识别和治疗,避免侵入性探查方法的医疗并发症和使用不必要的资源是很重要的。
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引用次数: 0
El corazón de la mujer 女人的心
Pub Date : 2019-07-01 DOI: 10.5354/2735-7996.2019.70051
J. Arocha R.
In the vast majority of cardiovascular diseases (CVDs), there are well-described differences between women and men in epidemiology, pathophysiology, clinical manifestations, effects of therapy, and outcomes. These differences arise on one hand from biological differences among women and men, which are called sex differences, due to differences in gene expression from the sex chromosomes and subsequent differences in sexual hormones leading to differences in gene expression and function in the CV system, In contrast, gender differences are unique to the human. They arise from sociocultural processes, such as different behaviours of women and men; exposure to specific influences of the environment; different forms of nutrition, lifestyle, or stress; or attitudes towards treatments and prevention. The scientific societies are at the forefront of implementing the knowledge in research and healthcare strategies with more proactive attitude for a feminine centered approaches may lead to a more specific and effective use of resources in CVD prevention and therapy in women.
在绝大多数心血管疾病(cvd)中,女性和男性在流行病学、病理生理学、临床表现、治疗效果和结局方面存在明显差异。这些差异一方面来自于女性和男性之间的生物学差异,这被称为性别差异,这是由于性染色体基因表达的差异以及随后性激素的差异导致了CV系统中基因表达和功能的差异。相反,性别差异是人类所独有的。它们产生于社会文化进程,例如男女的不同行为;暴露于环境的特定影响;不同形式的营养、生活方式或压力;或者对治疗和预防的态度。科学协会在实施研究和医疗保健策略方面的知识方面处于最前沿,对以女性为中心的方法采取更积极的态度,可能会导致在女性心血管疾病预防和治疗中更具体和有效地利用资源。
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引用次数: 0
Prevención no farmacológica de las exacerbaciones en la EPOC: efecto antiinflamatorio de la actividad física 慢性阻塞性肺病加重的非药物预防:体育活动的抗炎作用
Pub Date : 2019-07-01 DOI: 10.5354/2735-7996.2019.70050
L. Mendoza i, Julia Guerrero P.
The chronic obstructive pulmonary disease (COPD) is the chronic respiratory condition most prevalent in adults, caused mainly by smoking. Its burden is progressively increasing and, according to the World Health Organization, is one of the main causes of mortality and disability around the world. Patients with COPD present acute worsening of the disease, defined as acute exacerbations, which are the main cause of hospitalizations and deaths. Therefore, it is crucial to identify effective interventions focused in their prevention. Patients with COPD present dyspnoea and intolerance to exercise responsible for a progressive reduction in the level of physical activity, which is an independent risk factor for future exacerbations and mortality. On the other hand, it has been demonstrated that COPD patients with low level of physical activity present higher marker levels of systemic inflammation. Interventions able to increase the level of physical activity in COPD patients have demonstrated positive effects in quality of life and a few clinical trials suggest that improving physical activity is able to prevent exacerbations. We hypothesize that these effects could be explained by changes in systemic inflammation secondary to an increase of physical activity.
慢性阻塞性肺疾病(COPD)是成人中最常见的慢性呼吸系统疾病,主要由吸烟引起。它的负担正在逐渐增加,据世界卫生组织称,它是世界各地死亡和残疾的主要原因之一。慢性阻塞性肺病患者表现为疾病的急性恶化,定义为急性恶化,这是住院和死亡的主要原因。因此,确定有效的预防措施至关重要。慢性阻塞性肺病患者存在呼吸困难和运动不耐受,导致身体活动水平逐渐降低,这是未来病情恶化和死亡的独立危险因素。另一方面,已经证明低体力活动水平的COPD患者存在更高的全身性炎症标志物水平。能够提高慢性阻塞性肺病患者体力活动水平的干预措施已被证明对生活质量有积极影响,一些临床试验表明,改善体力活动能够预防病情恶化。我们假设这些影响可以通过继发于体力活动增加的全身性炎症变化来解释。
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引用次数: 0
Manejo de la enfermedad tiroídea en el embarazo y puerperio 妊娠和产褥期甲状腺疾病的管理
Pub Date : 2019-07-01 DOI: 10.5354/2735-7996.2019.70053
Paula Vergara U., Verónica Araya Q., Álvaro Sepúlveda-Martínez, Mauro Parra-Cordero
1. Conocer los valores normales de TSH durante el embarazo y las últimas recomendaciones según sociedades internacionales. 2. Conocer el seguimiento y manejo de la enfermedad tiroídea durante el embarazo. 3. Conocer las modificaciones que se debe realizar al tratamiento de la enfermedad tiroídea previamente diagnosticada, al conocerse el estado de embarazo. 4. Conocer los fármacos recomendados para el manejo de la enfermedad tiroídea durante el embarazo y puerperio. 5. Conocer la utilidad de la pesquisa de anticuerpos antitiroídeos en el embarazo y a quién solicitarlos. 6. Conocer el seguimiento ecográfico adecuado del feto cuya madre está afectada por alguna patología tiroídea.
1. 了解怀孕期间TSH的正常值和国际社会的最新建议。2. 了解怀孕期间甲状腺疾病的监测和管理。3. 了解在怀孕状态已知后,对先前诊断的甲状腺疾病的治疗应作出的修改。4. 了解孕期和产褥期甲状腺疾病治疗的推荐药物。5. 了解妊娠期抗甲状腺抗体研究的有用性和向谁申请。6. 了解母亲受甲状腺疾病影响的胎儿的适当超声随访。
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引用次数: 0
Programa de autopsias virtuales o “virtuopsias” en el Hospital Clínico Universidad de Chile. Un importante eslabón para la generación de nuevo conocimiento y mejoramiento continuo. 智利大学临床医院的虚拟尸检项目或“virtuopsias”。是产生新知识和持续改进的重要环节。
Pub Date : 2019-03-16 DOI: 10.5354/2735-7996.2019.69995
Patricia Gómez M., María Elena Zúñiga G.
Most of today´s medical knowledge of current advances in medicine are based on autopsy findings and patological studies conducted during the 19th century. At the end of the 60s, autopsies began to decline in many countries, for multivariate reasons. Nowadays, autopsies are almost no longer performed unless legal reasons are present. The so important and didactic Pathological Anatomy Meetings are not being held anymore either. These instances played a particularly important role, bringing together and gathering experts and apprentices from different medical areas and disciplines. Unfortunately they have been disappearing from hospitals. However, physicians still seem to need them, as many times there is urgent need to get reliable information about the etiology of thepatients’ symptoms and the ultimate causes that led him or her to death. The relevance of this information for generating new knowledge and proposing new diagnostic or therapeutic tools for continuous improvement, both in the field of healthcare and training is indisputable. Unfortunately, we still face situations in which a patient dies in the midst of many doubts regarding the ultimate cause of death. At the University of Chile Clinical Hospital, a so-called Adverse Event Meetings have been held every Thursday for several years. A lot of time is spent trying to elucidate what could have happened, in an attempt to detect errors that could have been corrected A team of doctors, midwives and nurses, analyze all the adverse events reported, step by step. In spite of this, there are situations where doubts still persist, once the meeting is over. Currents advances in imaging, immune-histochemistry, molecular and genetic study techniques can make possible today to obtain most important information without the need for a traditional autopsy. These technologies, appear then as a substitute for traditional autopsies, since the realization of some of these post-mortem studies would allow to elucidate many diagnostic doubts, improving diagnostic.
当今医学进展的大部分医学知识都是基于19世纪进行的尸检发现和病理学研究。60年代末,由于多种原因,尸检在许多国家开始减少。如今,除非有合法的理由,否则几乎不再进行尸体解剖。如此重要和说教的病理解剖会议也不再举行了。这些实例发挥了特别重要的作用,将来自不同医学领域和学科的专家和学徒聚集在一起。不幸的是,他们已经从医院消失了。然而,医生似乎仍然需要它们,因为很多时候迫切需要获得有关患者症状的病因和导致他或她死亡的最终原因的可靠信息。在医疗保健和培训领域,这些信息对于产生新知识和提出新的诊断或治疗工具以持续改进的相关性是无可争议的。不幸的是,我们仍然面临这样的情况:病人在对最终死因有许多疑问的情况下死亡。在智利大学临床医院,几年来每周四都会召开所谓的不良事件会议。医生、助产士和护士组成的团队一步一步地分析所有报告的不良事件,他们花了很多时间试图阐明可能发生的事情,试图发现本可以纠正的错误。尽管如此,在某些情况下,一旦会议结束,怀疑仍然存在。目前在成像、免疫组织化学、分子和遗传研究技术方面的进步,使今天不需要传统的尸检就能获得最重要的信息成为可能。这些技术作为传统尸检的替代品出现,因为其中一些尸检研究的实现将有助于阐明许多诊断上的疑问,从而提高诊断水平。
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引用次数: 0
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Revista Hospital Clínico Universidad de Chile
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