Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995560
Adriana Arza Valdés, Jorge Mario Garzón Rey, M. Gayoso, J. Aguiló
Nowadays some surgery protocols includes Patient Empowerment as a key factor to enhance patient's mental state to achieve better surgical results. Since 2011, the “Fast Track Prosthetic Knee Project” at the Clinic Hospital of Barcelona (Spain) includes an educational session as patient empowerment previous to knee arthroplasty surgery. This paper presents a study performed in 41 patients measuring the evolution of emotional stress generated by knee arthroplasty surgical intervention during the educational session. Differences in emotional stress before and after an educational session were analyzed, by using psychometric tests and heart rate variability (HRV) as indicators of stress. Both physiological and psychological measurements suggest the effectiveness of the empowerment session through a higher wellness state of patients, decreasing stress psychometric test value of 45.06% compared to their initial values and increasing the mean HRV 6.08%, with significant p-value (p<;0.0005) of paired samples T-student test, which corroborate that patients have a different stress state before and after the empowerment session. Additionally a Pearson correlation of -0.273 (p=0.02) between these stress indicators confirms that a HRV increase could be associated with less stressed state.
{"title":"Patient empowerment and stress reduction","authors":"Adriana Arza Valdés, Jorge Mario Garzón Rey, M. Gayoso, J. Aguiló","doi":"10.1109/IBERSENSOR.2014.6995560","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995560","url":null,"abstract":"Nowadays some surgery protocols includes Patient Empowerment as a key factor to enhance patient's mental state to achieve better surgical results. Since 2011, the “Fast Track Prosthetic Knee Project” at the Clinic Hospital of Barcelona (Spain) includes an educational session as patient empowerment previous to knee arthroplasty surgery. This paper presents a study performed in 41 patients measuring the evolution of emotional stress generated by knee arthroplasty surgical intervention during the educational session. Differences in emotional stress before and after an educational session were analyzed, by using psychometric tests and heart rate variability (HRV) as indicators of stress. Both physiological and psychological measurements suggest the effectiveness of the empowerment session through a higher wellness state of patients, decreasing stress psychometric test value of 45.06% compared to their initial values and increasing the mean HRV 6.08%, with significant p-value (p<;0.0005) of paired samples T-student test, which corroborate that patients have a different stress state before and after the empowerment session. Additionally a Pearson correlation of -0.273 (p=0.02) between these stress indicators confirms that a HRV increase could be associated with less stressed state.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127568924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995525
Francisco Salomón, S. Tropea, Diego Brengi, Ariel Hernandez, Diego Alamon, Matias Parra, G. Longinotti, G. Ybarra, P. Lloret, Mijal Mass, Mariano Roberti, Matías Lloret, L. Malatto, C. Moina, L. Fraigi, Luciano J Melli, M. E. Cortina, D. Serantes, J. E. Ugalde, Andrés E Ciocchini, D. Comerci
In this work, we present the development of a point-of-care platform for the serologic diagnosis of infectious diseases. The complete system consists of magnetic particles with immobilized antigens, disposable electrochemical cells, hardware and software. The main purpose of this paper is to present the last two components. The platform is powered by a rechargeable battery and can be controlled using mobile devices, allowing point-of-care diagnosis of diseases. The platform was successfully tested for the diagnosis of foot-and-mouth disease, human and bovine brucellosis, and Chagas disease.
{"title":"Smartphone controlled platform for point-of-care diagnosis of infectious diseases","authors":"Francisco Salomón, S. Tropea, Diego Brengi, Ariel Hernandez, Diego Alamon, Matias Parra, G. Longinotti, G. Ybarra, P. Lloret, Mijal Mass, Mariano Roberti, Matías Lloret, L. Malatto, C. Moina, L. Fraigi, Luciano J Melli, M. E. Cortina, D. Serantes, J. E. Ugalde, Andrés E Ciocchini, D. Comerci","doi":"10.1109/IBERSENSOR.2014.6995525","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995525","url":null,"abstract":"In this work, we present the development of a point-of-care platform for the serologic diagnosis of infectious diseases. The complete system consists of magnetic particles with immobilized antigens, disposable electrochemical cells, hardware and software. The main purpose of this paper is to present the last two components. The platform is powered by a rechargeable battery and can be controlled using mobile devices, allowing point-of-care diagnosis of diseases. The platform was successfully tested for the diagnosis of foot-and-mouth disease, human and bovine brucellosis, and Chagas disease.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126922535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995515
Susana M. Silva, Jorge D. Gamarra, C. A. Hernández, J. Osma
We present the design and fabrication process for an electrochemical “electronic nose” type sensor. This metal oxide based system focuses on the detection of ammonia as a possible sign of Ammonium nitrate based explosives, the main ingredients used by Armed Groups outside the law in Colombia for their Improvised Explosive Devices. The characterization of the conductivity variations of the zinc oxide sensor was made by a voltage divisor with constant input and serial data acquisition using an Arduino Uno® and MatLab® software. This is the first step in a more complex system for improvised explosive devices.
{"title":"Design and fabrication of a sensor for explosives as a first step to an IED detection device","authors":"Susana M. Silva, Jorge D. Gamarra, C. A. Hernández, J. Osma","doi":"10.1109/IBERSENSOR.2014.6995515","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995515","url":null,"abstract":"We present the design and fabrication process for an electrochemical “electronic nose” type sensor. This metal oxide based system focuses on the detection of ammonia as a possible sign of Ammonium nitrate based explosives, the main ingredients used by Armed Groups outside the law in Colombia for their Improvised Explosive Devices. The characterization of the conductivity variations of the zinc oxide sensor was made by a voltage divisor with constant input and serial data acquisition using an Arduino Uno® and MatLab® software. This is the first step in a more complex system for improvised explosive devices.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123607931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995517
J. Cabrera-Lopez, Manuel Esteban Latorre Victoria, Pablo Andres Mejia Jaramillo
Today, the environmental monitoring and quality have a growing interest. This promotes the development of new monitoring tools, and especially those with outstanding reliability and response time, and nonstationary features. This paper presents the design and implementation of a transportable gas detection and environmental monitoring device. Ideas taken from the Arduino and Lego constructions are kept in mind during the design of the device, looking further facilitate the development of product family of this device; likewise, the use of reconfigurable and interconnectable platforms with open hardware are considered. The transducers have been selected based on their reliability, small size and easy inclusion in an electronic system. Then, was developed a device that supports transducers for environmental gases, such as: carbon monoxide (CO), ozone (O3), volatile organic compounds (VOC), nitrogen dioxide (NO2) and sulfur dioxide (SO2); as well as the possibility to interface with other systems for common gases such as carbon dioxide (CO2) and oxygen (O2) before developed. Other environmental measures such as speed and wind direction, temperature and relative humidity, may also be included. In this case, a configurable platform based on mixed-signal circuits, PSoC5, was used for the development of embedded system. This platform can be interfaced with different Arduino shields and achieves the integration of several analog functions. This system manages, acquires and processes signals from the above transducers. The measurements can be displayed on an LCD display, save into an SD memory and send to the Web using Ethernet interface. The device is hand size, easy to carry and can operate with a battery. Its user interface is simple and provides updated and in-situ readings. Currently, successful results have been obtained from the functional and metrology testing of the manufactured prototype.
{"title":"An electronic and transportable nose for environmental gases monitoring based on mixed-signal SoC and open hardware","authors":"J. Cabrera-Lopez, Manuel Esteban Latorre Victoria, Pablo Andres Mejia Jaramillo","doi":"10.1109/IBERSENSOR.2014.6995517","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995517","url":null,"abstract":"Today, the environmental monitoring and quality have a growing interest. This promotes the development of new monitoring tools, and especially those with outstanding reliability and response time, and nonstationary features. This paper presents the design and implementation of a transportable gas detection and environmental monitoring device. Ideas taken from the Arduino and Lego constructions are kept in mind during the design of the device, looking further facilitate the development of product family of this device; likewise, the use of reconfigurable and interconnectable platforms with open hardware are considered. The transducers have been selected based on their reliability, small size and easy inclusion in an electronic system. Then, was developed a device that supports transducers for environmental gases, such as: carbon monoxide (CO), ozone (O3), volatile organic compounds (VOC), nitrogen dioxide (NO2) and sulfur dioxide (SO2); as well as the possibility to interface with other systems for common gases such as carbon dioxide (CO2) and oxygen (O2) before developed. Other environmental measures such as speed and wind direction, temperature and relative humidity, may also be included. In this case, a configurable platform based on mixed-signal circuits, PSoC5, was used for the development of embedded system. This platform can be interfaced with different Arduino shields and achieves the integration of several analog functions. This system manages, acquires and processes signals from the above transducers. The measurements can be displayed on an LCD display, save into an SD memory and send to the Web using Ethernet interface. The device is hand size, easy to carry and can operate with a battery. Its user interface is simple and provides updated and in-situ readings. Currently, successful results have been obtained from the functional and metrology testing of the manufactured prototype.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131166888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995539
E. Hernández-Gómez, J. Olvera-Cervantes, A. Corona‐Chavez, M. Sosa‐Morales
This work shows a low cost system for dielectric permittivity sensor in the microwave frequency range. All components of system are described. With this system, the real part of permittivity of low loss dielectrics can be obtained. It provides the same results that a Vector Network Analyzer (VNA). The permittivities of Teflon, wood, paper, white and yellow corn and sorghum are obtained.
{"title":"Development of a low cost dielectric permittivity sensor for organic and inorganic materials in the microwave frequency range","authors":"E. Hernández-Gómez, J. Olvera-Cervantes, A. Corona‐Chavez, M. Sosa‐Morales","doi":"10.1109/IBERSENSOR.2014.6995539","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995539","url":null,"abstract":"This work shows a low cost system for dielectric permittivity sensor in the microwave frequency range. All components of system are described. With this system, the real part of permittivity of low loss dielectrics can be obtained. It provides the same results that a Vector Network Analyzer (VNA). The permittivities of Teflon, wood, paper, white and yellow corn and sorghum are obtained.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"176 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121720948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995549
Houari Cobas Gomez, A. Seabra, Valker Araujo Feitosa, Juliana de Novais Schianti, Adriano Marim de Oliveira, Luciana Wasnievski da Silva de Luca Ramos, M. Gongora-Rubio
Low Temperature Co-fired Ceramic (LTCC) Microsystem technology have a relevant role in the miniaturization of Chemical Processes area. Microfluidic devices have been applied to carry out several chemical processes operations, including mixing, separation, chemical reactions, heterogeneous catalysis, heat exchange and so on. More recently, LTCC microfluidic systems are employed to produce micro and nanoparticles with excellent control of size distribution, morphology and constitution. The present work reports the development of a LTCC Micro Spray Dryer for Micro and Nanoparticle fabrication showing simulation results and experimental work.
{"title":"Development of a LTCC Micro Spray Dryer","authors":"Houari Cobas Gomez, A. Seabra, Valker Araujo Feitosa, Juliana de Novais Schianti, Adriano Marim de Oliveira, Luciana Wasnievski da Silva de Luca Ramos, M. Gongora-Rubio","doi":"10.1109/IBERSENSOR.2014.6995549","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995549","url":null,"abstract":"Low Temperature Co-fired Ceramic (LTCC) Microsystem technology have a relevant role in the miniaturization of Chemical Processes area. Microfluidic devices have been applied to carry out several chemical processes operations, including mixing, separation, chemical reactions, heterogeneous catalysis, heat exchange and so on. More recently, LTCC microfluidic systems are employed to produce micro and nanoparticles with excellent control of size distribution, morphology and constitution. The present work reports the development of a LTCC Micro Spray Dryer for Micro and Nanoparticle fabrication showing simulation results and experimental work.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124866406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995513
V. F. Cardoso, A. N. Rodrigues da Silva, Z. M. Rocha, A. Seabra, C. Jiménez-Jorquera, A. Cadarso
The use of analytical systems capable of performing analysis of high amount of chemical parameters is growing up. These microsystems known as μ-TAS (Micro Total Analysis Systems) can replace many steps carried out in laboratories allowing a more accurate and autonomous process. The sensors based in the microelectronic technology has a lot to offer to μTAS due to its small size and mass production. To reach a high level of miniaturization these devices are integrated in its bare die shape. However, the bonding pads finish in these devices is made of aluminum, which do not allow a direct soldering process using solder pastes for a flip chip assembly method. This work addresses this issue, evaluating the solderability using lead-free solder pastes for two solder bump processes: the SBB (Stud Ball Bumping) and Electroless Ni/Au UBM (Under Bump Metallurgy) in order to allow the interconnection between different sensors and substrates.
{"title":"Gold ball bumping versus E-less Ni/Au remetallization for chemical sensor integration using lead-free soldering for flip chip assembly","authors":"V. F. Cardoso, A. N. Rodrigues da Silva, Z. M. Rocha, A. Seabra, C. Jiménez-Jorquera, A. Cadarso","doi":"10.1109/IBERSENSOR.2014.6995513","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995513","url":null,"abstract":"The use of analytical systems capable of performing analysis of high amount of chemical parameters is growing up. These microsystems known as μ-TAS (Micro Total Analysis Systems) can replace many steps carried out in laboratories allowing a more accurate and autonomous process. The sensors based in the microelectronic technology has a lot to offer to μTAS due to its small size and mass production. To reach a high level of miniaturization these devices are integrated in its bare die shape. However, the bonding pads finish in these devices is made of aluminum, which do not allow a direct soldering process using solder pastes for a flip chip assembly method. This work addresses this issue, evaluating the solderability using lead-free solder pastes for two solder bump processes: the SBB (Stud Ball Bumping) and Electroless Ni/Au UBM (Under Bump Metallurgy) in order to allow the interconnection between different sensors and substrates.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126877311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995537
W. Serrano, A. Meléndez, I. Ramos, N. Pinto
Poly(lactic acid)PLA is a biocompatible and biodegradable polyester with lactic acid being a byproduct of decomposition. PLA can be produced via processing starch, it is mechanically robust and environmentally stable and has therefore attracted interest in applications such as biomedical implants, controlled drug delivery and other kitchen variety commodity products. Making PLA electrically conductive via blending it with conducting polymers will extend its range of applications to include electronic devices and sensors. Commercial PLA has a hard grainy morphology, but is readily soluble in organic solvents and can be cast into thin films, fibers, foams or other forms. A fiber typically has a larger surface area to volume ratio compared to films and is thus technologically advantageous for sensor applications. We have successfully prepared conducting PLA/PANi nanofibers at low PLA concentrations in CHCl3 and used it to sense alcohol vapors of increasing molecular size. The larger the size of the alcohol molecule, the longer it took for the sensor to reach saturation and the sensitivity was smaller. The sensor response times were found to be slower than the recovery times by more than two orders of magnitude for the larger alcohol molecules. Since larger molecules were not able to penetrate the fibers, they were easier to remove. The fiber sensors could be tested on various alcohols without damage and hence were reusable. Conducting PLA based nanofibers therefore present yet another means of fabricating gas sensors and that are biocompatible.
{"title":"Sensor response of electrospun poly(lactic acid)/polyaniline nanofibers to aliphatic alcohol vapors of varying sizes","authors":"W. Serrano, A. Meléndez, I. Ramos, N. Pinto","doi":"10.1109/IBERSENSOR.2014.6995537","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995537","url":null,"abstract":"Poly(lactic acid)PLA is a biocompatible and biodegradable polyester with lactic acid being a byproduct of decomposition. PLA can be produced via processing starch, it is mechanically robust and environmentally stable and has therefore attracted interest in applications such as biomedical implants, controlled drug delivery and other kitchen variety commodity products. Making PLA electrically conductive via blending it with conducting polymers will extend its range of applications to include electronic devices and sensors. Commercial PLA has a hard grainy morphology, but is readily soluble in organic solvents and can be cast into thin films, fibers, foams or other forms. A fiber typically has a larger surface area to volume ratio compared to films and is thus technologically advantageous for sensor applications. We have successfully prepared conducting PLA/PANi nanofibers at low PLA concentrations in CHCl3 and used it to sense alcohol vapors of increasing molecular size. The larger the size of the alcohol molecule, the longer it took for the sensor to reach saturation and the sensitivity was smaller. The sensor response times were found to be slower than the recovery times by more than two orders of magnitude for the larger alcohol molecules. Since larger molecules were not able to penetrate the fibers, they were easier to remove. The fiber sensors could be tested on various alcohols without damage and hence were reusable. Conducting PLA based nanofibers therefore present yet another means of fabricating gas sensors and that are biocompatible.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"2 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131938395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995548
Liz Katherine Rincon Ardila, M. Gongora-Rubio, Luciana Wasnievski da Silva Ramos, Adriano Marim de Oliveira, Tatiana Santana Balogh, Valker Araujo Feitosa, Natalia Neto Pereira Cerize, Houari Cobas Gomez
Encapsulated nano/micro particles are highly used for biological, chemical, pharmaceutical and medical applications. The polymeric particles show potential capacity to release drugs and compatibility in biological environments. The emulsion/diffusion process is applied to produce these particles, and technologies based on microfluidic provide miniaturization of such process allowing particles with physical and chemical controlled characteristics. Nevertheless, the integrated system of technological devices like sensors, microactuators and controllers is crucial to improve the performance and efficiency of particles production with automatic cycles. The proposal of this work is to develop the integrated system to produce nano/microparticles for drug encapsulation, using microfluidics devices with control and automatic actions in continuous scale. The system is developed through devices integration, system characterization and control loops, using sensors, pumps, microfluidics devices, communication drivers, data acquisition, and control programs. The result of this work is the integrated system to produce particles of size 499-1500 nm with polydispersity index of 0.3 to 0.5 with potential to be used as drug delivery systems. The experimental results were validated by size measurement and polydispersity distribution with optical microscopy, scanning electron microscopy and dynamic light scattering.
{"title":"Integrated system to produce nano/microparticles for drug delivery using LTCC microfluidics devices","authors":"Liz Katherine Rincon Ardila, M. Gongora-Rubio, Luciana Wasnievski da Silva Ramos, Adriano Marim de Oliveira, Tatiana Santana Balogh, Valker Araujo Feitosa, Natalia Neto Pereira Cerize, Houari Cobas Gomez","doi":"10.1109/IBERSENSOR.2014.6995548","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995548","url":null,"abstract":"Encapsulated nano/micro particles are highly used for biological, chemical, pharmaceutical and medical applications. The polymeric particles show potential capacity to release drugs and compatibility in biological environments. The emulsion/diffusion process is applied to produce these particles, and technologies based on microfluidic provide miniaturization of such process allowing particles with physical and chemical controlled characteristics. Nevertheless, the integrated system of technological devices like sensors, microactuators and controllers is crucial to improve the performance and efficiency of particles production with automatic cycles. The proposal of this work is to develop the integrated system to produce nano/microparticles for drug encapsulation, using microfluidics devices with control and automatic actions in continuous scale. The system is developed through devices integration, system characterization and control loops, using sensors, pumps, microfluidics devices, communication drivers, data acquisition, and control programs. The result of this work is the integrated system to produce particles of size 499-1500 nm with polydispersity index of 0.3 to 0.5 with potential to be used as drug delivery systems. The experimental results were validated by size measurement and polydispersity distribution with optical microscopy, scanning electron microscopy and dynamic light scattering.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134396392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-29DOI: 10.1109/IBERSENSOR.2014.6995558
Siva Kumar-Krishnan, O. Arias de Fuentes, E. Prokhorov, J. G. Luna-Bárcenas
The electrochemical detection of H2O2 and glucose based upon chitosan-stabilized silver nanowires (CS-AgNWs) onto a modified glassy carbon electrode is demonstrated. AgNWs synthesized through polyol process with high yield were used as electrocatalytic material to construct the modified electrode. CS-AgNWs modified glassy carbon electrode without enzyme (CS-AgNWs/GCE) exhibits excellent catalytic performance toward H2O2 reduction with sensitivity of 24.34 μAmM-1cm-2. Furthermore, the enzyme electrode prepared by immobilizing glucose oxidase (GOx)n the CS-AgNWs (CS-AgNWs/GOx/GCE) exhibits well defined redox peaks at -0.65 V. Peak current increases with increasing the glucose concentration from 1 to 12 mM with sensitivity to glucose of 14.6 μAmM-1cm-2. Consequently, this CS-AgNWs modified electrode is a promising candidate for H2O2 sensor and enzyme-based glucose biosensors.
研究了壳聚糖稳定银纳米线(CS-AgNWs)在改性玻碳电极上对H2O2和葡萄糖的电化学检测。以多元醇法制备的高产率AgNWs为电催化材料，制备了改性电极。CS-AgNWs修饰无酶玻碳电极(CS-AgNWs/GCE)对H2O2还原具有优异的催化性能，灵敏度为24.34 μ am -1cm-2。此外，将葡萄糖氧化酶(GOx)固定在CS-AgNWs上制备的酶电极(CS-AgNWs/GOx/GCE)在-0.65 V处表现出清晰的氧化还原峰。葡萄糖浓度从1 ~ 12 mM增加，峰值电流增加，对葡萄糖的敏感性为14.6 μ am -1cm-2。因此，这种CS-AgNWs修饰电极是H2O2传感器和酶基葡萄糖生物传感器的有希望的候选者。
{"title":"Electrochemical detection of hydrogen peroxide and glucose based on chitosan stabilized silver nanowire modified electrodes","authors":"Siva Kumar-Krishnan, O. Arias de Fuentes, E. Prokhorov, J. G. Luna-Bárcenas","doi":"10.1109/IBERSENSOR.2014.6995558","DOIUrl":"https://doi.org/10.1109/IBERSENSOR.2014.6995558","url":null,"abstract":"The electrochemical detection of H<sub>2</sub>O<sub>2</sub> and glucose based upon chitosan-stabilized silver nanowires (CS-AgNWs) onto a modified glassy carbon electrode is demonstrated. AgNWs synthesized through polyol process with high yield were used as electrocatalytic material to construct the modified electrode. CS-AgNWs modified glassy carbon electrode without enzyme (CS-AgNWs/GCE) exhibits excellent catalytic performance toward H<sub>2</sub>O<sub>2</sub> reduction with sensitivity of 24.34 μAmM<sup>-1</sup>cm<sup>-2</sup>. Furthermore, the enzyme electrode prepared by immobilizing glucose oxidase (GOx)n the CS-AgNWs (CS-AgNWs/GOx/GCE) exhibits well defined redox peaks at -0.65 V. Peak current increases with increasing the glucose concentration from 1 to 12 mM with sensitivity to glucose of 14.6 μAmM<sup>-1</sup>cm<sup>-2</sup>. Consequently, this CS-AgNWs modified electrode is a promising candidate for H<sub>2</sub>O<sub>2</sub> sensor and enzyme-based glucose biosensors.","PeriodicalId":296271,"journal":{"name":"2014 IEEE 9th IberoAmerican Congress on Sensors","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124150359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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