Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385010
L. Mescia, P. Bia, C. Lamacchia, M. A. Chiapperino, A. Miani
Electroporation technique is based on the perturbation of the cell membrane through the application of high-voltage electric pulses of short duration. In this paper, a non–linear dispersive model of the electroporation process in irregularly nucleated shaped cells is presented. In particular, the nuclear envelope was modeled as two lipid membranes separated by a perinuclear space. The dispersive properties of biological media was taken into account using a Debye–based relationship. The Multiphysics model solves simultaneously the Maxwell equations, the Smoluchowski equation, describing the creation and closure of pores, and the equations describing the temporal evolution of pore radius.
{"title":"Electroporation Modelling of Irregularly Nucleated Cell With Perinuclear Space","authors":"L. Mescia, P. Bia, C. Lamacchia, M. A. Chiapperino, A. Miani","doi":"10.1109/IMBIoC47321.2020.9385010","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385010","url":null,"abstract":"Electroporation technique is based on the perturbation of the cell membrane through the application of high-voltage electric pulses of short duration. In this paper, a non–linear dispersive model of the electroporation process in irregularly nucleated shaped cells is presented. In particular, the nuclear envelope was modeled as two lipid membranes separated by a perinuclear space. The dispersive properties of biological media was taken into account using a Debye–based relationship. The Multiphysics model solves simultaneously the Maxwell equations, the Smoluchowski equation, describing the creation and closure of pores, and the equations describing the temporal evolution of pore radius.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125198140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385045
Semih Doğu, Egemen Bilgin, Sulayman Joof, M. N. Akıncı
In this paper, we analyze the feasibility of using microwaves to detect early stage of congestive heart failure, which causes water accumulation in the lungs. To this aim, a slice from realistic human torso phantom, which consists of all human tissues and organs, is considered. Constitutive parameters of the phantom are calculated by multiple order Cole-Cole model at operating frequency. Then, the scattered field is calculated via method of moment and a 30 dB additive white Gaussian noise is added to create a more realistic scenario. In the solution of inverse scattering phase, distorted Born iterative method is utilized. The presented results show the feasibility of the proposed method.
{"title":"Feasibility of Distorted Born Iterative Method for Detecting Early Stage of Heart Failure","authors":"Semih Doğu, Egemen Bilgin, Sulayman Joof, M. N. Akıncı","doi":"10.1109/IMBIoC47321.2020.9385045","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385045","url":null,"abstract":"In this paper, we analyze the feasibility of using microwaves to detect early stage of congestive heart failure, which causes water accumulation in the lungs. To this aim, a slice from realistic human torso phantom, which consists of all human tissues and organs, is considered. Constitutive parameters of the phantom are calculated by multiple order Cole-Cole model at operating frequency. Then, the scattered field is calculated via method of moment and a 30 dB additive white Gaussian noise is added to create a more realistic scenario. In the solution of inverse scattering phase, distorted Born iterative method is utilized. The presented results show the feasibility of the proposed method.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125060251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385017
Masahito Nakamura, T. Tajima, M. Seyama
This paper proposes a novel measurement method for admittance modelling of open-ended coaxial probes that measure two-layer material independently of the thickness of the first layer for dielectric spectroscopy of the inner layer. The penetration depth of a coaxial probe depends on the probe aperture, which results in differences in the measured effective dielectric constant for layered materials. Therefore, our analytical admittance model uses two coaxial probes with different penetration depths, and we calculate the admittance using the effective dielectric constant measured by both probes. We evaluated the accuracy of the model by in vitro measurement, assuming biomedical samples such as human skin. The results show good agreement with measured admittance in the frequency range from 0.5 to 10 GHz. The error with the measured admittance was within 10%, though the thickness of the first layer was not included in the calculation. Since biological materials are composed of a two-layer structure to retain moisture, the proposed method is expected to be used for novel biological sensing applications.
{"title":"Two-Coaxial-Probe Method for Dielectric Spectroscopy of Two-Layer Materials Towards Biological Application","authors":"Masahito Nakamura, T. Tajima, M. Seyama","doi":"10.1109/IMBIoC47321.2020.9385017","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385017","url":null,"abstract":"This paper proposes a novel measurement method for admittance modelling of open-ended coaxial probes that measure two-layer material independently of the thickness of the first layer for dielectric spectroscopy of the inner layer. The penetration depth of a coaxial probe depends on the probe aperture, which results in differences in the measured effective dielectric constant for layered materials. Therefore, our analytical admittance model uses two coaxial probes with different penetration depths, and we calculate the admittance using the effective dielectric constant measured by both probes. We evaluated the accuracy of the model by in vitro measurement, assuming biomedical samples such as human skin. The results show good agreement with measured admittance in the frequency range from 0.5 to 10 GHz. The error with the measured admittance was within 10%, though the thickness of the first layer was not included in the calculation. Since biological materials are composed of a two-layer structure to retain moisture, the proposed method is expected to be used for novel biological sensing applications.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125582693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385020
H. S. Pisheh, Arda Secme, H. Uslu, Berk Kucukoglu, M. Hanay
Here, we propose a nanopore integrated microwave resonator to detect single nanoparticles in real time. In contrast to existing nanopore-sensors relying on detection techniques like resistive pulse sensing, and current-voltage measurements, the presented coplanar-waveguide sensor detects the passage of gold nanoparticles through a nanopore on a thin film membrane. Resonance frequency of the sensor, which is around 7 GHz, is tracked by a custom-built close loop circuitry. Gold nanoparticles are electro kinetically driven through the pore: as each nanoparticle passed the pore, it induces a shift in the resonance frequency of the resonator. The presented method is not limited by the specific design of the pore, alleviating the stringing condition on pore size and shape with respect to the target analyte.
{"title":"Detection of Single Gold Nanoparticle in Liquid With Nanopore-Integrated Microwave Resonators","authors":"H. S. Pisheh, Arda Secme, H. Uslu, Berk Kucukoglu, M. Hanay","doi":"10.1109/IMBIoC47321.2020.9385020","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385020","url":null,"abstract":"Here, we propose a nanopore integrated microwave resonator to detect single nanoparticles in real time. In contrast to existing nanopore-sensors relying on detection techniques like resistive pulse sensing, and current-voltage measurements, the presented coplanar-waveguide sensor detects the passage of gold nanoparticles through a nanopore on a thin film membrane. Resonance frequency of the sensor, which is around 7 GHz, is tracked by a custom-built close loop circuitry. Gold nanoparticles are electro kinetically driven through the pore: as each nanoparticle passed the pore, it induces a shift in the resonance frequency of the resonator. The presented method is not limited by the specific design of the pore, alleviating the stringing condition on pore size and shape with respect to the target analyte.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127279885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385041
Supawat Kotchapradit, Metharak Jokpudsa, T. Thosdeekoraphat, Manot Mapato, C. Thongsopa
This paper presents a high-frequency dielectric heating system for breast cancer treatment. The power loss density (W/m 3) was investigated with a curved plate applicator by 3D simulation. The dielectric constant and loss factor of tumor tissue provides 55.25 and 19.8, respectively. This dielectric heating system was implemented based on the high power signal generator 2450 MHz, which is designed by a series resonance circuit with an LC matching element. The dielectric properties of breast phantom and tumor tissue were performing by open-ended coaxial dielectric probe kit connected to a vector network analyzer that can be operated in the range of 1-10 GHz. The impedance matching was measured in breast phantom as a surrogate tumor tissue with an applicator. The heat distribution on tumor tissue was measured using IR cameras. The parameters of microwave DC input power 180 W, efficiency about 30%, and get power at 60 W (47.82 dBm) to generate a stabilized temperature between $39-4 2^{circ}mathrm{C}$.
{"title":"Implementation of High-Frequency Dielectric Heating System for Breast Cancer Treatment","authors":"Supawat Kotchapradit, Metharak Jokpudsa, T. Thosdeekoraphat, Manot Mapato, C. Thongsopa","doi":"10.1109/IMBIoC47321.2020.9385041","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385041","url":null,"abstract":"This paper presents a high-frequency dielectric heating system for breast cancer treatment. The power loss density (W/m 3) was investigated with a curved plate applicator by 3D simulation. The dielectric constant and loss factor of tumor tissue provides 55.25 and 19.8, respectively. This dielectric heating system was implemented based on the high power signal generator 2450 MHz, which is designed by a series resonance circuit with an LC matching element. The dielectric properties of breast phantom and tumor tissue were performing by open-ended coaxial dielectric probe kit connected to a vector network analyzer that can be operated in the range of 1-10 GHz. The impedance matching was measured in breast phantom as a surrogate tumor tissue with an applicator. The heat distribution on tumor tissue was measured using IR cameras. The parameters of microwave DC input power 180 W, efficiency about 30%, and get power at 60 W (47.82 dBm) to generate a stabilized temperature between $39-4 2^{circ}mathrm{C}$.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129431176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385012
L. Anishchenko, M. Bochkarev, L. Korostovtseva, Y. Sviryaev, A. Bugaev
Lack of effective non-contact ways for long-term sleep movements disorders detection, which may indicate the presence of different health and life-threatening conditions, is an up-to-date problem of modern sleep medicine. This paper presents a method for remote long-term sleep movements monitoring based on the analysis of a bioradar signal. The method was validated utilizing data of four volunteers, which underwent a sleep study in a sleep laboratory of Almazov National Medical Research Centre. The proposed method is based on the usage of a long short-term memory network to detect leg movements during sleep. We achieved accuracy and Cohen's kappa of 0.99 and 0.98 for leg movements during sleep classification, respectively. The results might be used while creating new methods for remote detection of sleep movement disorders.
{"title":"Remote Limb Movement Analysis During Sleep by Means of Bioradar","authors":"L. Anishchenko, M. Bochkarev, L. Korostovtseva, Y. Sviryaev, A. Bugaev","doi":"10.1109/IMBIoC47321.2020.9385012","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385012","url":null,"abstract":"Lack of effective non-contact ways for long-term sleep movements disorders detection, which may indicate the presence of different health and life-threatening conditions, is an up-to-date problem of modern sleep medicine. This paper presents a method for remote long-term sleep movements monitoring based on the analysis of a bioradar signal. The method was validated utilizing data of four volunteers, which underwent a sleep study in a sleep laboratory of Almazov National Medical Research Centre. The proposed method is based on the usage of a long short-term memory network to detect leg movements during sleep. We achieved accuracy and Cohen's kappa of 0.99 and 0.98 for leg movements during sleep classification, respectively. The results might be used while creating new methods for remote detection of sleep movement disorders.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"310 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122778416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385049
A. Zapasnoy, V. Belichenko, A. Klokov, A. Mironchev, A. Gorst, K. Zavyalova, V. Yakubov
In this paper, theoretical and experimental studies of physical processes occurring during the interaction of electromagnetic fields with biological tissues containing blood vessels with a small depth are given. A new approach is aimed at creating a near-field microwave sounding system for regular non-invasive monitoring of glucose levels. A feature of the proposed approach is the use of significant changes in the phase state of the near field in the vicinity of the so-called “causal surface”. At the first stage of the study, numerical simulation made it possible to obtain a picture of the interaction of near field of the wideband sensor of a special design with samples of biological tissues of various types. The most important thing in this work is that the geometry of the sensor provides the formation of an extended near-field zone with a high level of electric field near its aperture. A study of the near-field interaction of the sensor with various biological tissues was carried out on the basis of an analysis of the behavior of the real part of the radiation flux. Since a change in a blood the level of glucose leads to changes in dielectric permeability, the largest changes in signal level should be expected in the radiation passing through the blood vessels. The second stage – experimental studies of the possibility of real measurement of glucose in the phantom of biological tissue. During the experiment, the complex reflection coefficient from the sensor was measured as a function of the frequency. First, the reflection coefficient was measured for saline solutions containing dextrose. Then the same procedure was repeated for a pure saline solution. Then followed the normalization (in doing so, we fully took into account the recommendations, concerning the reduction of the influence of various negative factors). Of particular interest, in our opinion, is the signal in the range from 4.3 to 4.6 GHz. In this frequency range, a clear correlation is observed between signal magnitudes and solution concentrations.
{"title":"Interaction of the Near-Field Microwave Wideband Sensor With Biological Tissues for Glucose Monitoring","authors":"A. Zapasnoy, V. Belichenko, A. Klokov, A. Mironchev, A. Gorst, K. Zavyalova, V. Yakubov","doi":"10.1109/IMBIoC47321.2020.9385049","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385049","url":null,"abstract":"In this paper, theoretical and experimental studies of physical processes occurring during the interaction of electromagnetic fields with biological tissues containing blood vessels with a small depth are given. A new approach is aimed at creating a near-field microwave sounding system for regular non-invasive monitoring of glucose levels. A feature of the proposed approach is the use of significant changes in the phase state of the near field in the vicinity of the so-called “causal surface”. At the first stage of the study, numerical simulation made it possible to obtain a picture of the interaction of near field of the wideband sensor of a special design with samples of biological tissues of various types. The most important thing in this work is that the geometry of the sensor provides the formation of an extended near-field zone with a high level of electric field near its aperture. A study of the near-field interaction of the sensor with various biological tissues was carried out on the basis of an analysis of the behavior of the real part of the radiation flux. Since a change in a blood the level of glucose leads to changes in dielectric permeability, the largest changes in signal level should be expected in the radiation passing through the blood vessels. The second stage – experimental studies of the possibility of real measurement of glucose in the phantom of biological tissue. During the experiment, the complex reflection coefficient from the sensor was measured as a function of the frequency. First, the reflection coefficient was measured for saline solutions containing dextrose. Then the same procedure was repeated for a pure saline solution. Then followed the normalization (in doing so, we fully took into account the recommendations, concerning the reduction of the influence of various negative factors). Of particular interest, in our opinion, is the signal in the range from 4.3 to 4.6 GHz. In this frequency range, a clear correlation is observed between signal magnitudes and solution concentrations.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126648315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385014
A. Shahzad, A. Elahi, Paidrig Donlon, M. O’halloran
This paper discusses the relationship of tissue water contents with the dielectric properties and develop a water dependent dielectric model. The proposed model provides a means of estimating in-vivo dielectric properties of body tissue from the mass fraction of water in the tissue. The estimated dielectric properties of tissue can play a vital role in hyperthermia treatment planning and electromagnetic medical device development.
{"title":"A Water Dependent Tissue Dielectric Model for Estimation of in-vivo Dielectric Properties","authors":"A. Shahzad, A. Elahi, Paidrig Donlon, M. O’halloran","doi":"10.1109/IMBIoC47321.2020.9385014","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385014","url":null,"abstract":"This paper discusses the relationship of tissue water contents with the dielectric properties and develop a water dependent dielectric model. The proposed model provides a means of estimating in-vivo dielectric properties of body tissue from the mass fraction of water in the tissue. The estimated dielectric properties of tissue can play a vital role in hyperthermia treatment planning and electromagnetic medical device development.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114768440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385029
Lena Kranold, Jasmine Boparai, L. Fortaleza, M. Popovic
This comparative study analyzes the dielectric properties of different skin mimicking tissue phantoms for the development of microwave radar prototypes for early breast cancer detection. Therefore, the properties of a fat mimicking carbon-polyurethane-based phantom were verified, and the dielectric properties of three different skin phantoms in four scenarios measured. Furthermore, the dielectric properties were compared to those of the excised human tissue reported in the literature.
{"title":"Comparative Study of Tissue-Mimicking Phantoms for Microwave Breast Cancer Screening Systems","authors":"Lena Kranold, Jasmine Boparai, L. Fortaleza, M. Popovic","doi":"10.1109/IMBIoC47321.2020.9385029","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385029","url":null,"abstract":"This comparative study analyzes the dielectric properties of different skin mimicking tissue phantoms for the development of microwave radar prototypes for early breast cancer detection. Therefore, the properties of a fat mimicking carbon-polyurethane-based phantom were verified, and the dielectric properties of three different skin phantoms in four scenarios measured. Furthermore, the dielectric properties were compared to those of the excised human tissue reported in the literature.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115178775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385015
P. Barmuta, T. Markovic, Camila Dalben Madeira Campos, Rahul Yadav, I. Ocket, W. Van Roy, T. Stakenborg, L. Lagae, J. Genoe, D. Schreurs, Chengxun Liu
This work presents a broadband setup for single-cell electrorotation. It is capable of generating relatively high voltage in a continuous frequency band starting from 50 kHz up to 5 GHz. The setup shows very small phase and amplitude imbalance, which were found negligible as no decentric movement of the cell was observed. At least 9.6 V of peak-peak voltage at the single electrode was achieved with total harmonic distortion of less than 5%. The results obtained on lymphocytes follow the theoretical curves, and show that higher frequency of operation means higher sensitivity to the dielectric permittivity of the cell cytoplasm.
{"title":"Broadband Measurement Setup for Cell Electrorotation","authors":"P. Barmuta, T. Markovic, Camila Dalben Madeira Campos, Rahul Yadav, I. Ocket, W. Van Roy, T. Stakenborg, L. Lagae, J. Genoe, D. Schreurs, Chengxun Liu","doi":"10.1109/IMBIoC47321.2020.9385015","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385015","url":null,"abstract":"This work presents a broadband setup for single-cell electrorotation. It is capable of generating relatively high voltage in a continuous frequency band starting from 50 kHz up to 5 GHz. The setup shows very small phase and amplitude imbalance, which were found negligible as no decentric movement of the cell was observed. At least 9.6 V of peak-peak voltage at the single electrode was achieved with total harmonic distortion of less than 5%. The results obtained on lymphocytes follow the theoretical curves, and show that higher frequency of operation means higher sensitivity to the dielectric permittivity of the cell cytoplasm.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125023728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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