Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385026
Carolina Moncion, I. S. B. Venkatakrishnan, A. Kiourti, J. R. Diaz, J. Volakis
A wireless neurosensing system (WiNS) adapted with a novel impedance matching network is presented and validated. This system is used in vivo to record for the first time spontaneous neural unit activity from the hippocampus of a Wistar rat. These extracellular spikes offer valuable information. However, they are challenging to observe, even more so with previously reported neurosensing systems due to impedance mismatches with the required neural probes. The notable result demonstrated here employed (a) recently proposed technique for passive impedance matching, and (b) newly explored impedance reducing electrochemical probe coating method. The proposed technology has revolutionary potential in neurological research, particularly in epilepsy studies.
{"title":"Recording Neural Spikes Using Wireless Neurosensing System","authors":"Carolina Moncion, I. S. B. Venkatakrishnan, A. Kiourti, J. R. Diaz, J. Volakis","doi":"10.1109/IMBIoC47321.2020.9385026","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385026","url":null,"abstract":"A wireless neurosensing system (WiNS) adapted with a novel impedance matching network is presented and validated. This system is used in vivo to record for the first time spontaneous neural unit activity from the hippocampus of a Wistar rat. These extracellular spikes offer valuable information. However, they are challenging to observe, even more so with previously reported neurosensing systems due to impedance mismatches with the required neural probes. The notable result demonstrated here employed (a) recently proposed technique for passive impedance matching, and (b) newly explored impedance reducing electrochemical probe coating method. The proposed technology has revolutionary potential in neurological research, particularly in epilepsy studies.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133571710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385025
T. Garcia-Sanchez, A. De Angelis, F. Apollonio, M. Liberti, L. Mir, C. Merla
The permeabilization of biological membranes by electric fields, known as electroporation and electropermeabilization, has been traditionally performed using square electric pulses. These signals distribute the energy in a wide frequency band. In this paper, authors investigate the use of sine waves, which are narrow band signals, to provoke electropermeabilization and the frequency dependence of this phenomenon. Single bursts of sine waves at different frequencies in the range from 8 kHz-130 kHz were applied to DC-3F cells. Electroporation was studied in the plasma membrane and the internal organelles membrane using calcium as a permeabilization marker. Additionally, a double-shell electrical model was simulated to give a theoretical framework to our results.
{"title":"The Frequency Dependent Response of Sinewave Electropermeabilization","authors":"T. Garcia-Sanchez, A. De Angelis, F. Apollonio, M. Liberti, L. Mir, C. Merla","doi":"10.1109/IMBIoC47321.2020.9385025","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385025","url":null,"abstract":"The permeabilization of biological membranes by electric fields, known as electroporation and electropermeabilization, has been traditionally performed using square electric pulses. These signals distribute the energy in a wide frequency band. In this paper, authors investigate the use of sine waves, which are narrow band signals, to provoke electropermeabilization and the frequency dependence of this phenomenon. Single bursts of sine waves at different frequencies in the range from 8 kHz-130 kHz were applied to DC-3F cells. Electroporation was studied in the plasma membrane and the internal organelles membrane using calcium as a permeabilization marker. Additionally, a double-shell electrical model was simulated to give a theoretical framework to our results.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133681922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385050
Maréva Calvet-Chautard, Patricio Felipe Jaque Gonzalez, T. Véronèse, D. Dubuc, K. Grenier
This paper presents a microwave sensor designed to dielectrically characterize tissues of animal origin (duck in our case) in the frequency range of 0.1 to 6 GHz for meat freshness evaluation. This contact sensor is used as a transmit-and-receive sensor. Its validity is firstly verified with reference liquids. A dielectric characterization is then performed on a duck breast at different maturation days. In each case, repeatability of the measurements was checked. The obtained dielectric response of the duck breast changes over time. This result enables the future use of the sensor and the measurement technique in various applications and for the agroindustry notably for the monitoring of the meat freshness.
{"title":"Microwave-Based Sensor Dedicated to the Characterization of Meat Freshness","authors":"Maréva Calvet-Chautard, Patricio Felipe Jaque Gonzalez, T. Véronèse, D. Dubuc, K. Grenier","doi":"10.1109/IMBIoC47321.2020.9385050","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385050","url":null,"abstract":"This paper presents a microwave sensor designed to dielectrically characterize tissues of animal origin (duck in our case) in the frequency range of 0.1 to 6 GHz for meat freshness evaluation. This contact sensor is used as a transmit-and-receive sensor. Its validity is firstly verified with reference liquids. A dielectric characterization is then performed on a duck breast at different maturation days. In each case, repeatability of the measurements was checked. The obtained dielectric response of the duck breast changes over time. This result enables the future use of the sensor and the measurement technique in various applications and for the agroindustry notably for the monitoring of the meat freshness.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115394198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385048
Arda Secme, H. S. Pisheh, H. Uslu, Ozge Akbulut, R. T. Erdogan, M. Hanay
The size of a cell is one of the most fundamental biophysical parameters it possesses. Traditionally size measurements are done by using optical microscopy and quantitative phase imaging. However, a sensor with higher resolution, high throughput and lower cost is still needed. Here, a novel microfluidics-integratedmicrowave sensor is demonstrated to characterize single cells in real-time without labelling. Coplanar waveguide resonator is designed with a bowtie-shaped sensing electrodes separated by $50 mu mathrm{m}$. Cells are transported to sensing region by microfluidic channels and their sizes are measured simultaneously by the microwave sensors and optical microscopy. To enhance the microwave resolution, the microwave resonator is equipped with external heterodyne measurement circuitry detecting each and every cell passing through the sensing region. By comparing quantitative microscopic image analysis with frequency shifts, we show that microwave sensors can effectively measure cellular size. Our results indicate that microfluidics-integrated microwave sensors (MIMS) can be used for detecting.
细胞的大小是它所拥有的最基本的生物物理参数之一。传统的尺寸测量是通过光学显微镜和定量相位成像来完成的。但是，仍然需要一种高分辨率、高吞吐量和低成本的传感器。在这里，一种新型的微流体集成微波传感器被证明可以实时表征单细胞而无需标记。共面波导谐振器采用领结形感应电极，电极间距为$50 mu mathm {m}$。通过微流控通道将细胞输送到传感区域，利用微波传感器和光学显微镜同时测量细胞的大小。为了提高微波分辨率，在微波谐振腔内配置外差测量电路，对通过感应区的每个细胞进行检测。通过与频移的定量显微图像分析比较，我们证明微波传感器可以有效地测量细胞大小。结果表明，微流控集成微波传感器(MIMS)可以用于检测。
{"title":"Microfluidics-Integrated Microwave Sensors for Single Cells Size Discrimination","authors":"Arda Secme, H. S. Pisheh, H. Uslu, Ozge Akbulut, R. T. Erdogan, M. Hanay","doi":"10.1109/IMBIoC47321.2020.9385048","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385048","url":null,"abstract":"The size of a cell is one of the most fundamental biophysical parameters it possesses. Traditionally size measurements are done by using optical microscopy and quantitative phase imaging. However, a sensor with higher resolution, high throughput and lower cost is still needed. Here, a novel microfluidics-integratedmicrowave sensor is demonstrated to characterize single cells in real-time without labelling. Coplanar waveguide resonator is designed with a bowtie-shaped sensing electrodes separated by $50 mu mathrm{m}$. Cells are transported to sensing region by microfluidic channels and their sizes are measured simultaneously by the microwave sensors and optical microscopy. To enhance the microwave resolution, the microwave resonator is equipped with external heterodyne measurement circuitry detecting each and every cell passing through the sensing region. By comparing quantitative microscopic image analysis with frequency shifts, we show that microwave sensors can effectively measure cellular size. Our results indicate that microfluidics-integrated microwave sensors (MIMS) can be used for detecting.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124957800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9384901
D. Nikolayev, W. Joseph, M. Zhadobov, L. Martens, R. Sauleau, A. Skrivervik
Fundamental in-body limitations on achievable radiation efficiency could provide decision-making assistance to engineers working on antennas for implantable bioelectronics. In this study, proof-of-concept conformal microstrip antennas are proposed based on these theoretical foundations. In particular, maximizing the effective aperture and loading the antenna with materials having the permittivity higher than that of surrounding tissues is a promising solution for increasing the radiation efficiency. The operating frequencies are tuned to operate within the optimal range for deep-body implantation: 434, 868, and 1400 MHz. The achieved radiation efficiencies at these frequencies are 0.4%, 2.2%, and 1.2%, respectively, when simulated in a $phi boldsymbol{100}$ – mm spherical phantom with muscle-equivalent electromagnetic properties. The radiation performance at each frequency is compared to the fundamental limitations and closely approach them. Prototypes are characterized for the experimental validation.
{"title":"Application of Fundamental In-Body Radiation Limitations to Practical Design of Antennas for Implantable Bioelectronics","authors":"D. Nikolayev, W. Joseph, M. Zhadobov, L. Martens, R. Sauleau, A. Skrivervik","doi":"10.1109/IMBIoC47321.2020.9384901","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9384901","url":null,"abstract":"Fundamental in-body limitations on achievable radiation efficiency could provide decision-making assistance to engineers working on antennas for implantable bioelectronics. In this study, proof-of-concept conformal microstrip antennas are proposed based on these theoretical foundations. In particular, maximizing the effective aperture and loading the antenna with materials having the permittivity higher than that of surrounding tissues is a promising solution for increasing the radiation efficiency. The operating frequencies are tuned to operate within the optimal range for deep-body implantation: 434, 868, and 1400 MHz. The achieved radiation efficiencies at these frequencies are 0.4%, 2.2%, and 1.2%, respectively, when simulated in a $phi boldsymbol{100}$ – mm spherical phantom with muscle-equivalent electromagnetic properties. The radiation performance at each frequency is compared to the fundamental limitations and closely approach them. Prototypes are characterized for the experimental validation.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125719482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9384905
L. Caramazza, A. De Angelis, M. Nardoni, P. Paolicelli, S. Petralito, F. Apollonio, M. Liberti
Radiofrequency (RF) signals as a way to remotely control smart drug delivery nanocarriers represent a promising tool to overcome traditional therapeutic issues, such as overdosing therapeutic agents with a reduced efficacy and related side effects on healthy tissues, in order to obtain a targeted release near diseased cells. Aim of this work is to provide a deep investigation on the possible effect of sine wave RF signals, of 100 kHz and 10 MHz, applied to a non-uniform random distribution of 142 liposomes, as a realistic model of a biocompatible drug delivery suspension, to study electroporation mechanisms occurring during exposure.
{"title":"Planning Sine Waves Electroporation on Liposomes for Drug Delivery Application","authors":"L. Caramazza, A. De Angelis, M. Nardoni, P. Paolicelli, S. Petralito, F. Apollonio, M. Liberti","doi":"10.1109/IMBIoC47321.2020.9384905","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9384905","url":null,"abstract":"Radiofrequency (RF) signals as a way to remotely control smart drug delivery nanocarriers represent a promising tool to overcome traditional therapeutic issues, such as overdosing therapeutic agents with a reduced efficacy and related side effects on healthy tissues, in order to obtain a targeted release near diseased cells. Aim of this work is to provide a deep investigation on the possible effect of sine wave RF signals, of 100 kHz and 10 MHz, applied to a non-uniform random distribution of 142 liposomes, as a realistic model of a biocompatible drug delivery suspension, to study electroporation mechanisms occurring during exposure.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"408 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125165227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385046
Endri Stoja, S. Konstandin, R. Wilke, Dennis Philipp, R. Umathum, J. Jenne, Diego Betancourt, T. Bertuch, M. Günther
A signal enhancement metasurface composed of a periodic linear alignment of closely–coupled wire resonators is proposed. It serves to locally enhance the radio frequency (RF) field in a specific region of interest for Magnetic Resonance Imaging (MRI). Electrical elongation by capacitive loading of the wires allows to adjust the resonance to an MR scanner's operating frequency of 123.5 MHz. Two prototypes are manufactured and characterized on-bench. MRI experiments allow to separate effects on the Tx/Rx fields showing an SNR enhancement factor up to 2.4.
{"title":"Design and Characterization of a Metasurface Enhancement Plate for 3T MRI","authors":"Endri Stoja, S. Konstandin, R. Wilke, Dennis Philipp, R. Umathum, J. Jenne, Diego Betancourt, T. Bertuch, M. Günther","doi":"10.1109/IMBIoC47321.2020.9385046","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385046","url":null,"abstract":"A signal enhancement metasurface composed of a periodic linear alignment of closely–coupled wire resonators is proposed. It serves to locally enhance the radio frequency (RF) field in a specific region of interest for Magnetic Resonance Imaging (MRI). Electrical elongation by capacitive loading of the wires allows to adjust the resonance to an MR scanner's operating frequency of 123.5 MHz. Two prototypes are manufactured and characterized on-bench. MRI experiments allow to separate effects on the Tx/Rx fields showing an SNR enhancement factor up to 2.4.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131496276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385022
K. Grenier, G. Pratviel, Hugo Mazur, D. Dubuc
This paper focuses on demonstrating the possible detection with microwave dielectric spectroscopy of the hydration modification of a protein submitted or not to a chaotropic agent. The case study of the denaturation of the large BSA protein with urea is investigated. A hydration contrast is extracted from microwave measurements and presents a linear relationship with the concentration of the denaturing agent. This result demonstrates that microwave dielectric spectroscopy could contribute to evaluate intramolecular change of conformation (structuration/destructuration) of biomacromolecules based on hydration modifications.
{"title":"Detection of a Macromolecule Denaturation With Microwave Dielectric Spectroscopy based on Hydration Modifications","authors":"K. Grenier, G. Pratviel, Hugo Mazur, D. Dubuc","doi":"10.1109/IMBIoC47321.2020.9385022","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385022","url":null,"abstract":"This paper focuses on demonstrating the possible detection with microwave dielectric spectroscopy of the hydration modification of a protein submitted or not to a chaotropic agent. The case study of the denaturation of the large BSA protein with urea is investigated. A hydration contrast is extracted from microwave measurements and presents a linear relationship with the concentration of the denaturing agent. This result demonstrates that microwave dielectric spectroscopy could contribute to evaluate intramolecular change of conformation (structuration/destructuration) of biomacromolecules based on hydration modifications.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134026622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385024
Kunal Wadhwani, Sheena Hussaini, Syed Azeemuddin
L–Lysine is an essential amino acid and bio–sample observing major significance in food processing, pharmaceutical and agricultural industries. Conventional sensing techniques require longer pre–processing times and are sensitive to ambient conditions. However, radio frequency (RF) sensing based on Complementary Split Ring Resonator (CSRR) exhibits a significant shift in the resonant frequency and is highly desirable for the L-Lysine's quantitative analysis. The frequency shifts of 498.4 MHz, 482.9 MHz, 471.4 MHz, 459.9 MHz and 452.3 MHz are obtained through varying concentrations from 0 mg/ml to 40 mg/ml in step size 10 mg/ml of L-Lysine solution. Therefore, experimental results and analysis presented in this work indicate the proposed radio frequency sensor's linearity in the above-reported concentration range.
{"title":"Real-time Quantitative Analysis of L-Lysine Based on Radio Frequency Sensing","authors":"Kunal Wadhwani, Sheena Hussaini, Syed Azeemuddin","doi":"10.1109/IMBIoC47321.2020.9385024","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385024","url":null,"abstract":"L–Lysine is an essential amino acid and bio–sample observing major significance in food processing, pharmaceutical and agricultural industries. Conventional sensing techniques require longer pre–processing times and are sensitive to ambient conditions. However, radio frequency (RF) sensing based on Complementary Split Ring Resonator (CSRR) exhibits a significant shift in the resonant frequency and is highly desirable for the L-Lysine's quantitative analysis. The frequency shifts of 498.4 MHz, 482.9 MHz, 471.4 MHz, 459.9 MHz and 452.3 MHz are obtained through varying concentrations from 0 mg/ml to 40 mg/ml in step size 10 mg/ml of L-Lysine solution. Therefore, experimental results and analysis presented in this work indicate the proposed radio frequency sensor's linearity in the above-reported concentration range.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128335913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385023
Xiaotian Du, Caroline Ladegard, Xiao Ma, Xuanhong Cheng, J. Hwang
Live Jurkat cells were trapped by dielectrophoresis on a coplanar waveguide and the resulted changes in its reflection and transmission coefficients were measured from 900 Hz to 40 GHz. The measurement confirms that the decrease of nucleus size in a cell increases its impacts on both the reflection and transmission coefficients. Being fast, compact and label free, broadband electrical sensing may be used to detect other changes of the nucleus morphology and DNA content, which could be useful for cancer diagnosis.
{"title":"Broadband Electrical Sensing of Nucleus Size in a Live Cell From 900 Hz to 40 GHz","authors":"Xiaotian Du, Caroline Ladegard, Xiao Ma, Xuanhong Cheng, J. Hwang","doi":"10.1109/IMBIoC47321.2020.9385023","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385023","url":null,"abstract":"Live Jurkat cells were trapped by dielectrophoresis on a coplanar waveguide and the resulted changes in its reflection and transmission coefficients were measured from 900 Hz to 40 GHz. The measurement confirms that the decrease of nucleus size in a cell increases its impacts on both the reflection and transmission coefficients. Being fast, compact and label free, broadband electrical sensing may be used to detect other changes of the nucleus morphology and DNA content, which could be useful for cancer diagnosis.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116115021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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