Eco-Environment & Health最新文献_第5页

Maternal exposure to fine particulate matter and pregnancy outcomes in women undergoing in vitro fertilization: A multicenter retrospective study 母体接触细颗粒物与体外受精妇女妊娠结局：一项多中心回顾性研究

IF 17.6

Eco-Environment & Health

Pub Date : 2025-10-15 DOI: 10.1016/j.eehl.2025.100192

Miaoxin Chen , Ying Fang , Yunxiu Li , Guimin Hao , Xueqing Wu , Yan Sun , Jichun Tan , Yue Niu , Xinyi Du , Yonggang Li , Zhuoye Luo , Fen Hu , Yuehong Li , Shanshan Wu , Yingying Yang , Orhan Bukulmez , Yeung William Shu-Biu , Robert J. Norman , Haidong Kan , Xiaoming Teng

Few large-scale studies have systematically examined the effects of maternal exposure to fine particulate matter (PM_2.5) on live birth in women undergoing in vitro fertilization (IVF). This study aimed to investigate the associations between ambient PM_2.5 exposure and live birth in women treated with IVF, and determine critical periods, key failure events, and vulnerable populations affected by such exposure. We included 58,637 patients from six reproductive centers in China between 2016 and 2021. We defined six exposure windows and adopted logistic regression with random-effect models to investigate the associations between PM_2.5 exposure and live birth. We further categorized live birth failure as implantation failure, biochemical pregnancy loss, and miscarriage, to determine at which stage PM_2.5 exposure caused the live birth failure. Subgroup analyses were conducted by female age, ovarian response, embryo quality, and transplantation protocol. For each 10 μg/m³ increase in PM_2.5 concentration during follicle growth phase, preantral-antral follicle phase, and antral-mature follicle phase, the odds ratios for live birth were 0.966 [95% confidence interval (CI): 0.938, 0.995], 0.967 (0.939, 0.996), and 0.978 (0.958, 0.998), respectively. PM_2.5 during these stages was significantly associated only with an increased likelihood of implantation failure, highlighting adverse impact of ambient PM_2.5 on early pregnancy outcome. In addition, we observed relatively stronger associations in women with poor ovarian response, compromised embryo quality, and those undergoing fresh or double embryo transfers. This large-scale population-based study demonstrated the detrimental effects of high PM_2.5 exposure for IVF women, shedding light on clinical and public health practices.

很少有大规模的研究系统地调查了母体暴露于细颗粒物（PM2.5）对体外受精（IVF）妇女活产的影响。本研究旨在探讨环境PM2.5暴露与体外受精妇女活产之间的关系，并确定受这种暴露影响的关键时期、关键失败事件和弱势群体。我们纳入了2016年至2021年间来自中国六个生殖中心的58,637名患者。我们定义了6个暴露窗口，并采用随机效应模型的逻辑回归来研究PM2.5暴露与活产之间的关系。我们进一步将活产失败分为着床失败、生化妊娠丢失和流产，以确定PM2.5暴露在哪个阶段导致活产失败。根据女性年龄、卵巢反应、胚胎质量和移植方案进行亚组分析。在卵泡生长期、卵泡前-卵泡期和卵泡成熟期，PM2.5浓度每增加10 μg/m3，活产的优势比分别为0.966（95%可信区间（CI）： 0.938, 0.995）、0.967（0.939,0.996）和0.978（0.958,0.998）。这些阶段的PM2.5仅与植入失败的可能性增加显著相关，突出了环境PM2.5对妊娠早期结局的不利影响。此外，我们观察到卵巢反应差、胚胎质量受损以及接受新鲜胚胎或双胚胎移植的妇女的相关性相对较强。这项大规模的基于人群的研究证明了高PM2.5暴露对试管婴儿妇女的有害影响，为临床和公共卫生实践提供了启示。

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引用次数: 0

Importance of control experiments in toxicity test of metal–organic frameworks: Recent advances and challenges 对照实验在金属有机骨架毒性试验中的重要性：最新进展与挑战

IF 17.6

Eco-Environment & Health

Pub Date : 2025-10-11 DOI: 10.1016/j.eehl.2025.100191

Xiaoqing Lu , Zhuying Yan , Fang Hao , Zhenyu Wang , Xianzheng Yuan , Xiaofan Yang , Tao Chen , Xiuping Yan

The commercial application of metal–organic frameworks (MOFs) in gas separation, catalysis, sensing, energy conversion, and storage inevitably leads to the release of MOFs into the environment, posing a great threat to the eco-environment. The toxic risk assessment of MOFs is necessary to achieve their sustainable applications. Reproducible and accurate measurement in toxicity assays is the first step in the risk evaluation of MOFs. However, a broad range of artifacts may occur in previous toxicity tests of MOFs due to diverse interferences. Therefore, control experiments are needed to discriminate such interferences and to revise the experimental protocol for the reduction and elimination of the artifacts. Herein, we present a review of the artifacts and control experiments in toxicity assays of MOFs in terms of MOF preparation, toxicity test, labeling and tracking, and co-exposure test. We also discuss the differences in the results of the toxicity test with and without a control experiment to illustrate the impact of the control experiment on the conclusion. We highlight the importance of a control experiment to reduce false negative or false positive results and to guarantee accurate toxicity data in the toxicity study of MOFs, which could advance the ecological risk assessment of MOFs as well as the safe-to-sustainable design of MOFs in tackling various challenges of future applications.

金属有机骨架（MOFs）在气体分离、催化、传感、能量转换和储存等方面的商业化应用，不可避免地导致MOFs向环境中释放，对生态环境构成极大威胁。对MOFs进行毒性风险评估是实现其可持续应用的必要条件。在毒性试验中可重复和准确的测量是MOFs风险评估的第一步。然而，在以往的mof毒性试验中，由于各种干扰，可能会出现大范围的伪影。因此，需要对照实验来区分这种干扰，并修改实验方案以减少和消除伪影。本文从MOF的制备、毒性试验、标记与跟踪、共暴露试验等方面综述了MOF毒性试验中的伪影和对照实验。我们还讨论了有对照实验和没有对照实验的毒性试验结果的差异，以说明对照实验对结论的影响。我们强调了在MOFs的毒性研究中，控制实验对于减少假阴性或假阳性结果和保证准确的毒性数据的重要性，这可以促进MOFs的生态风险评估以及MOFs的安全可持续设计，以应对未来应用中的各种挑战。

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引用次数: 0

The detoxification paradox: Rethinking microbial dehalogenation in environmental remediation 解毒悖论：环境修复中微生物脱卤的再思考

IF 17.6

Eco-Environment & Health

Pub Date : 2025-10-03 DOI: 10.1016/j.eehl.2025.100190

Qian Wang , Shuai Wang , Yueli Hu , Jiaxin Wu , Shanyuan Niu

引用次数: 0

Improving Four-pre ability for flood in alpine regions 提高高寒地区抗洪能力

IF 17.6

Eco-Environment & Health

Pub Date : 2025-10-01 DOI: 10.1016/j.eehl.2025.100189

Li Zhou , Haowen Li , Zhongshun Gu , Yinan Guo , Xiaopeng Wang , Biqiong Wu , Lingling Wu , Chun Zhou , Zhipan Niu

引用次数: 0

From water to sediment: A meta-analysis of microplastic distribution and the impact of dams in reservoir ecosystems 从水到沉积物：微塑料分布和水库生态系统中水坝影响的荟萃分析

IF 17.6

Eco-Environment & Health

Pub Date : 2025-09-26 DOI: 10.1016/j.eehl.2025.100188

Wei Gao , Peng Zhang , Hongcui Wang , Xiaohan Yang , Chunjiang An

Microplastics (MPs) have become major contaminants in freshwater ecosystems. While numerous studies have characterized MPs in reservoirs, a comprehensive synthesis focusing on in-reservoir variations and dam-related influences is still lacking. This study investigates the spatial distribution of MPs in reservoir water and sediment based on data synthesized from 34 peer-reviewed studies covering 36 reservoirs across diverse climatic and hydrological regions worldwide, with a focus on the trapping effects of dams. Using a combination of generalized linear mixed models (GLMM) and generalized additive mixed models (GAMM), the study analyzed MP abundance patterns in relation to distance to the dam and identified key environmental and anthropogenic factors influencing their distribution. The results show that MPs tend to accumulate near dams, suggesting a trapping effect, while upstream MP concentrations decline with increasing distance. Vertical stratification patterns were observed in both water and sediment, indicating different transport mechanisms. Additionally, exposure to MPs significantly affected benthic organisms, particularly in terms of growth and reproduction, with effects intensifying over longer exposure durations. These findings highlight the need for improved monitoring and management strategies in reservoirs to mitigate MP pollution and its ecological consequences.

微塑料已成为淡水生态系统的主要污染物。虽然有大量的研究对水库中的MPs进行了表征，但对水库内变化和大坝相关影响的综合研究仍然缺乏。本研究基于34项同行评审研究的数据，调查了水库水和沉积物中MPs的空间分布，这些研究涵盖了全球不同气候和水文区域的36个水库，重点研究了水坝的捕获效应。采用广义线性混合模型（GLMM）和广义加性混合模型（GAMM）相结合的方法，分析了MP丰度与大坝距离的关系，并确定了影响MP丰度分布的关键环境和人为因素。结果表明，多聚物倾向于在水坝附近积聚，表明存在捕获效应，而上游多聚物浓度随着距离的增加而下降。在水和沉积物中均观察到垂直分层模式，表明不同的输送机制。此外，暴露于多磺酸粘多糖显著影响底栖生物，特别是在生长和繁殖方面，影响随着暴露时间的延长而加剧。这些发现强调了改善水库监测和管理策略的必要性，以减轻多聚磷污染及其生态后果。

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引用次数: 0

Emerging flame retardants in the marine environment: A comprehensive review of occurrence, fate and analytical challenges 海洋环境中新出现的阻燃剂：发生、命运和分析挑战的全面回顾

IF 17.6

Eco-Environment & Health

Pub Date : 2025-09-18 DOI: 10.1016/j.eehl.2025.100186

Muhammad Zeshan , Menghao Gao , Yuan Gao , Haijun Zhang , Jiping Chen

Emerging flame retardant (EFR) pollutants are ubiquitous in marine environment due to their extensive applications, and capacity for persistence and long-range atmospheric transport. The accurate analysis of EFRs in marine matrices remains challenging due to the inherently low sensitivity and selectivity in complex matrices, matrix-induced signal suppression, limited analytical throughput, and the lack of robust non-target screening protocols. This review provides an integration of recent methodological breakthroughs, encompassing sensitive instrumental approaches and innovative extraction and purification techniques for EFR detection in marine multi-matrix. The environmental occurrence and process of EFRs highlight that the roles of particle-mediated transport, plastic debris leaching, and photochemical degradation co-govern the fate of EFRs in marine environments. Furthermore, the review critically examines the ecological risks of EFRs, focusing on their bioaccumulation-driven toxicity, trophic magnification in marine food webs, and the potential for ecosystem destabilization. Mechanistic insights into photochemical transformation pathways are summarized, highlighting the formation of persistent and more toxic products that raise risks of chronic exposure and ecological disruption in marine environment. It provides a scientific foundation for regulatory agencies to assess marine environmental risks and implement targeted mitigation strategies. Future research should focus on quantifying the ecological impacts of EFRs to support a more effective monitoring and management framework.

新兴阻燃剂（EFR）由于其广泛的应用、持久性和远距离大气迁移能力，在海洋环境中无处不在。由于在复杂基质中固有的低灵敏度和选择性、基质诱导的信号抑制、有限的分析通量以及缺乏可靠的非靶点筛选方案，海洋基质中efr的准确分析仍然具有挑战性。本文综述了最近在方法上的突破，包括灵敏的仪器方法和创新的提取和纯化技术，用于海洋多基质中EFR检测。EFRs的环境发生和过程表明，颗粒介导的运输、塑料碎片的浸出和光化学降解共同支配着EFRs在海洋环境中的命运。此外，该综述还严格审查了efr的生态风险，重点关注其生物积累驱动的毒性、海洋食物网的营养放大以及生态系统不稳定的可能性。总结了光化学转化途径的机理，强调了持久性和毒性更强的产物的形成，这些产物增加了海洋环境中长期暴露和生态破坏的风险。它为监管机构评估海洋环境风险和实施有针对性的缓解战略提供了科学基础。未来的研究应侧重于量化efr的生态影响，以支持更有效的监测和管理框架。

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引用次数: 0

Co-exposure of di(2-ethylhexyl) phthalate (DEHP) decreased the submicron plastic stress in soil–plant system 邻苯二甲酸二（2-乙基己基）酯（DEHP）共暴露降低了土壤-植物系统的亚微米塑性应力

IF 17.6

Eco-Environment & Health

Pub Date : 2025-09-12 DOI: 10.1016/j.eehl.2025.100184

Yu Wang , Fang Wang , Leilei Xiang , Maoyuan Liao , Mingyi Wang , Yongrong Bian , Xin Jiang , Ravi Naidu , Matthias C. Rillig , Wulf Amelung

The widespread use of agricultural plastic films has made micro- and nanoplastics (MNPs) and phthalate esters (PAEs) contaminants of emerging concern in agroecosystems. However, the interactive mechanisms underlying their combined pollution in soil–plant systems remain elusive. To fill this gap, this study investigated the interaction between submicron plastics (SMPs, 0.01% and 0.1% w/w) and di(2-ethylhexyl) phthalate (DEHP) in soil–lettuce systems. Contrary to the anticipated synergistic toxicity, DEHP significantly reduced SMP uptake into and by cracked surface cells of lettuce roots (with root concentration factors decreasing by 19%–64%), i.e., DEHP alleviated SMP-induced oxidative stress, as evidenced by reduced levels of reactive oxygen species (−26.8% and −66.7%) and antioxidant enzyme activities (−118% and −128%). Metabolomic profiling revealed that SMP exposure significantly dysregulated multiple metabolic pathways (amino acid, carbohydrate, energy, glycan, lipid, and nucleotide metabolism), while SMP + DEHP co-exposure selectively attenuated these metabolic disturbances, showing enrichment only in glycan biosynthesis/metabolism and suppressing SMP-induced perturbations in other pathways (biosynthesis of secondary metabolites, energy metabolism, and signal transduction). Microbial community analysis showed that high-level SMP exposure significantly diminished bacterial α-diversity and amplicon sequence variant (ASV) richness, whereas DEHP supplementation enhanced those of Myxococcota in the soil, potentially counterbalancing SMP-induced microbial dysbiosis. These findings collectively demonstrate that co-contamination by MNPs and plastic additives may produce antagonistic interactions rather than uniformly synergistic effects, and provide a more comprehensive evaluation of the risks of PAEs and MNPs to food security, human health, and ecological environment.

农用塑料薄膜的广泛使用使得微、纳米塑料（MNPs）和邻苯二甲酸酯（PAEs）污染物成为农业生态系统日益关注的问题。然而，它们在土壤-植物系统中联合污染的相互作用机制仍然难以捉摸。为了填补这一空白，本研究调查了亚微米塑料（SMPs， 0.01%和0.1% w/w）与土壤-生菜系统中邻苯二甲酸二（2-乙基己基）酯（DEHP）之间的相互作用。与预期的协同毒性相反，DEHP显著降低了生菜根裂表面细胞对SMP的吸收（根浓度因子降低了19%-64%），即DEHP减轻了SMP诱导的氧化应激，这可以从活性氧水平（- 26.8%和- 66.7%）和抗氧化酶活性（- 118%和- 128%）的降低中得到证明。代谢组学分析显示，SMP暴露显著失调了多种代谢途径（氨基酸、碳水化合物、能量、聚糖、脂质和核苷酸代谢），而SMP + DEHP共暴露选择性地减弱了这些代谢紊乱，仅在聚糖生物合成/代谢中富集，抑制了SMP诱导的其他途径（次生代谢物的生物合成、能量代谢和信号转导）的扰动。微生物群落分析表明，高水平的SMP暴露显著降低了土壤细菌α-多样性和扩增子序列变异（ASV）丰富度，而补充DEHP提高了土壤中粘球菌的多样性和丰富度，可能抵消了SMP诱导的微生物生态失调。这些研究结果共同表明，MNPs和塑料添加剂的共同污染可能产生拮抗相互作用，而不是统一的协同效应，并为更全面地评估PAEs和MNPs对粮食安全、人类健康和生态环境的风险提供了依据。

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引用次数: 0

Serum phthalates and risks of incident cardiovascular disease among individuals with type 2 diabetes in a prospective cohort study 在一项前瞻性队列研究中，2型糖尿病患者血清邻苯二甲酸酯和心血管疾病发生的风险

IF 17.6

Eco-Environment & Health

Pub Date : 2025-09-11 DOI: 10.1016/j.eehl.2025.100185

Shiyang Zhang , Xu Cheng , Chengyong Jia , Jun An , Xin Zhang , Youbing Guan , Yan Yan , Zhuoya Zhao , Yuenan Liu , Tao Jing , Meian He

Prospective epidemiological evidence about the associations between phthalates (PAEs) and incident cardiovascular disease (CVD) risk among type 2 diabetes mellitus (T2DM) population has been urgently needed. A total of 2806 participants with T2DM were recruited based on the baseline of the Dongfeng-Tongji cohort study (2008–2010) and followed up to 2018. Serum di-n-butyl phthalate (DnBP), Σdibutyl phthalate (ΣDBP), and Σlow-molecular-weight phthalate (ΣLMW) levels were associated with incident stroke risk, whether their levels were treated as continuous variables [HR (95%CI): 1.36 (1.02, 1.80), 1.35 (1.01, 1.81), and 1.50 (1.07, 2.10), respectively] or divided by quartiles [HR (95%CI): 1.41 (1.01, 1.98), 1.48 (1.05, 2.08), and 1.53 (1.08, 2.15) in the highest quartile with P_trend = 0.03, 0.02, and 0.02, respectively] after multiple adjustment in Cox proportional hazard models. Meanwhile, linear associations for serum di-iso-butyl phthalate (DiBP), DnBP, ΣDBP, and ΣLMW, and a nonlinear U-shaped dose–response association for serum butyl-benzyl phthalate (BBP) with incident stroke risk were proved by restricted cubic spline regression analyses. Furthermore, a positive correlation between PAE mixture and incident stroke risk was identified in Quantile-based g-computation [HR (95%CI): 1.24 (1.05, 1.46)]. However, serum PAEs, either as individuals or as a mixture, were not associated with incident CVD or coronary heart disease risk. Our study revealed that serum PAEs were positively associated with increased incident stroke risk in the T2DM population. More prospective cohort and mechanism studies are warranted to validate our findings.

目前迫切需要关于邻苯二甲酸酯（PAEs）与2型糖尿病（T2DM）人群心血管疾病（CVD）风险之间关系的前瞻性流行病学证据。根据东风-同济队列研究（2008-2010）的基线，共招募2806名T2DM患者，随访至2018年。血清邻苯二甲酸二丁酯（DnBP）、Σdibutyl邻苯二甲酸酯（ΣDBP）和Σlow-molecular-weight邻苯二甲酸酯（ΣLMW）水平与卒中发生风险相关，无论它们的水平是否被视为连续变量[比差（95%CI）分别为1.36（1.02,1.80）、1.35（1.01,1.81）和1.50(1.07,2.10)]或按四分位数划分[比差（95%CI）：Cox比例风险模型经多重调整后最高四分位数分别为1.41（1.01,1.98）、1.48（1.05,2.08）、1.53 (1.08,2.15)，Ptrend分别为0.03、0.02、0.02。同时，通过限制三次样条回归分析，证明了血清邻苯二甲酸二异丁酯（DiBP）、DnBP、ΣDBP和ΣLMW与卒中发生风险呈线性相关，以及血清邻苯二甲酸丁酯（BBP）与卒中发生风险呈非线性u型剂量反应相关。此外，基于分位数的g计算发现PAE混合物与卒中发生风险呈正相关[HR (95%CI): 1.24(1.05, 1.46)]。然而，血清PAEs，无论是作为个体还是作为混合物，都与心血管疾病或冠心病的发生风险无关。我们的研究表明，血清PAEs与T2DM人群卒中发生风险增加呈正相关。需要更多的前瞻性队列和机制研究来验证我们的发现。

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引用次数: 0

Climate, urbanization, and infectious disease: Environmental drivers of Foshan's chikungunya outbreak 气候、城市化和传染病：佛山基孔肯雅热爆发的环境驱动因素

IF 17.6

Eco-Environment & Health

Pub Date : 2025-08-23 DOI: 10.1016/j.eehl.2025.100179

Chang He , Guiying Li , Taicheng An

引用次数: 0

A critical review on temperature-mediated marine plastic biodegradation 温度介导的海洋塑料生物降解研究综述

IF 17.6

Eco-Environment & Health

Pub Date : 2025-08-20 DOI: 10.1016/j.eehl.2025.100177

Yuanmei Zhang, Yiqi Cao, Bing Chen, Baiyu Zhang

Biodegradation offers a promising solution to marine plastic pollution. Temperature plays a significant role in biofilm development and microbial dynamics. However, comprehensive studies on the effects of temperature on marine plastic biodegradation remain limited, as most research focuses on individual and moderate temperatures, overlooking how temperature variations across polar to tropical marine environments interact with other ecological factors to influence plastic biodegradation. This review summarizes current research on temperature-induced biofilm formation, microbial succession, and enzymatic depolymerization of plastics. The findings reveal that higher temperatures generally enhance biofilm growth. Notably, cold-tolerant bacteria stimulate the production of extracellular polymeric substances (EPS) to stabilize biofilms and adapt to cold conditions. Microbial succession, particularly within the Proteobacteria phylum, is primarily regulated by temperature, driving shifts in microbial diversity and activity. For different types of plastics, the hydrolyzable ones are degraded via enzymes such as cutinases, lipases, and depolymerases, mostly at mild temperatures. In contrast, non-hydrolyzable plastics are relatively recalcitrant to enzymatic breakdown but can be biodeteriorated by enzyme-generated reactive oxygen species (ROS), with minimal temperature influence due to their slow biodegradation. This review emphasizes the critical role of temperature in biodegradation processes and prospects for promising strategies for improving marine plastic management under the changing climate.

生物降解为解决海洋塑料污染提供了一个很有前途的解决方案。温度在生物膜发育和微生物动力学中起着重要的作用。然而，关于温度对海洋塑料生物降解影响的综合研究仍然有限，因为大多数研究都集中在个体和中等温度上，忽视了极地到热带海洋环境的温度变化如何与其他生态因素相互作用，影响塑料的生物降解。本文综述了塑料在温度诱导生物膜形成、微生物演代和酶解聚方面的研究进展。研究结果表明，较高的温度通常会促进生物膜的生长。值得注意的是，耐寒细菌刺激细胞外聚合物质（EPS）的产生，以稳定生物膜并适应寒冷条件。微生物演替，特别是变形菌门内的微生物演替，主要受温度调节，驱动微生物多样性和活动的变化。对于不同类型的塑料，可水解的塑料主要在温和的温度下通过诸如角质酶、脂肪酶和解聚合酶等酶进行降解。相比之下，不可水解塑料相对不易被酶分解，但可以被酶产生的活性氧（ROS）生物降解，由于其生物降解缓慢，温度影响最小。这篇综述强调了温度在生物降解过程中的关键作用，并展望了在气候变化下改善海洋塑料管理的有希望的策略。

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引用次数: 0