Eco-Environment & Health最新文献_第10页

Prenatal ozone exposure is associated with children overweight and obesity: Evidence from the Shanghai Maternal–Child Pairs Cohort 产前臭氧暴露与儿童超重和肥胖有关：来自上海母婴配对队列的证据

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-05-08 DOI: 10.1016/j.eehl.2024.04.008

Prenatal ozone (O₃) exposure may disrupt normal offspring growth. However, epidemiological evidence that prenatal O₃ exposure affects the physical development of offspring early in life is far from adequate. A total of 4909 maternal–child pairs from the Shanghai Maternal–Child Pairs Cohort were included. A high-resolution random forest model was utilized to evaluate prenatal exposure levels of O₃ based on the home addresses of pregnant women. Group-based trajectory and mixed-effects models were used to assess associations between prenatal O₃ exposure and physical parameters. Each 10 μg/m³ increase in O₃ concentration was associated with 0.084, 0.048, and 0.082-unit increases in body mass index (BMI) for age Z score (BAZ), weight for age Z score (WAZ), and weight for length Z score (WLZ), respectively. Specifically, a 10 μg/m³ increase in O₃ concentration was linked to a 1.208-fold and 1.209-fold increase in the elevated-increasing group for the BAZ and WLZ trajectories, respectively. Moreover, each 10 μg/m³ increases in prenatal O₃ was associated with a 1.396-fold and 0.786-fold increase in the risk of BAZ- and length for age Z score (LAZ)-accelerated growth, respectively. Furthermore, a 10 μg/m³ increase in prenatal O₃ was linked to a 1.355-fold increase in the risk of overweight and obesity (OAO). Our study revealed that prenatal O₃ exposure is associated with accelerated BMI gain or decelerated body length gain in the early life of children. Prenatal O₃ may also increase the risk of OAO in children for the first two years.

产前接触臭氧（O3）可能会破坏后代的正常发育。然而，产前接触臭氧会影响后代早期身体发育的流行病学证据还远远不够。本研究共纳入了 4909 对来自上海母子配对队列的母子。根据孕妇的家庭住址，利用高分辨率随机森林模型来评估产前的臭氧暴露水平。采用基于群体的轨迹和混合效应模型来评估产前臭氧暴露与身体参数之间的关联。臭氧浓度每增加 10 微克/立方米，体重指数（BMI）年龄 Z 值（BAZ）、体重年龄 Z 值（WAZ）和体重身长 Z 值（WLZ）分别增加 0.084、0.048 和 0.082 个单位。具体而言，在 BAZ 和 WLZ 轨迹中，O3 浓度每增加 10 μg/m³ 与升高增加组的联系分别为 1.208 倍和 1.209 倍。此外，产前臭氧浓度每增加 10 μg/m³ 与 BAZ 和年龄 Z 评分（LAZ）加速生长的风险分别增加 1.396 倍和 0.786 倍有关。此外，产前 O3 每增加 10 μg/m³ ，超重和肥胖（OAO）的风险就会增加 1.355 倍。我们的研究表明，产前接触臭氧与儿童早期体重指数加速增长或体长减速增长有关。产前接触臭氧还可能会增加儿童在头两年出现 OAO 的风险。

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引用次数: 0

Crop plants transport irregularly shaped mineral particles from root to shoot: Tracking and quantifying 农作物植物将形状不规则的矿物质颗粒从根部运输到嫩芽：跟踪和量化

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-05-22 DOI: 10.1016/j.eehl.2024.05.002

Jie Yang , Lianzhen Li , Chen Tu , Ruijie Li , Yongming Luo

Mineral particles, ubiquitous in soils, influence crop plant growth by carrying nutrients and pollutants. While the uptake of dissolved mineral nutrients is well-established, the direct incorporation of irregular mineral particles into plants remains unclear. This study investigated the uptake and transport of kaolin particles, representative of minerals, by wheat and lettuce seedlings using hydroponic and soil cultures. Covalent labeling and advanced microscopy revealed that kaolin enters root steles at lateral root emergence sites, followed by transport to shoots. Fluorescent dyes and lanthanum (La)-labeled kaolin particles demonstrated that wheat surpassed lettuce in kaolin uptake in hydroponics, but both plants showed similar levels of particles in the shoots. Translocation factors (TFs) for kaolin were significantly higher in soil (0.089 for wheat, 0.039 for lettuce) compared to hydroponics (0.001 for wheat, 0.003 for lettuce). These findings provide compelling evidence for the direct uptake and transport of kaolin particles in crop plants. This opens new avenues for research on the interactions between plant and mineral particles, including other colloidal particles, in terrestrial ecosystems.

矿物颗粒在土壤中无处不在，通过携带养分和污染物影响作物的生长。虽然对溶解矿物质养分的吸收已得到证实，但不规则矿物质颗粒直接融入植物体内的情况仍不清楚。本研究采用水培和土壤培养的方法，调查了小麦和莴苣幼苗对高岭土颗粒（矿物质的代表）的吸收和运输情况。共价标记和高级显微镜显示，高岭土进入侧根萌发部位的根茎，然后被运输到嫩芽。荧光染料和镧（La）标记的高岭土颗粒表明，小麦在水培过程中对高岭土的吸收超过了莴苣，但这两种植物在芽中的颗粒含量相似。高岭土的转移因子（TFs）在土壤中（小麦为 0.089，莴苣为 0.039）明显高于水培植物（小麦为 0.001，莴苣为 0.003）。这些发现为作物植物直接吸收和运输高岭土颗粒提供了有力的证据。这为研究陆地生态系统中植物与矿物颗粒（包括其他胶体颗粒）之间的相互作用开辟了新的途径。

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引用次数: 0

Associating prenatal phthalate exposure with childhood autistic traits: Investigating potential adverse outcome pathways and the modifying effects of maternal vitamin D 产前接触邻苯二甲酸盐与儿童自闭症特征的关系：研究潜在的不良后果途径和母体维生素 D 的调节作用

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-02-07 DOI: 10.1016/j.eehl.2024.01.007

The association between prenatal phthalate mixture exposure and the risk of autism spectrum disorder (ASD) in children, as well as the potential mechanism and impact of maternal vitamin D, remains unclear. We analyzed data from 3209 mother–child pairs. The associations between prenatal phthalate exposure and autistic traits in children aged 1.5, 3, 5, and 6 years were explored. Furthermore, the modifying effects of maternal vitamin D and the adverse outcome pathway, which elucidates the contribution of phthalates to ASD, were estimated. Exposure to a phthalate mixture was associated with an increased risk of ASD in children aged 1.5–6 years. For mothers with 25(OH)D deficiency, an exposure‒response relationship was observed between phthalate mixtures in early to mid-pregnancy and autistic traits in children aged 3 years. However, this association was not observed for mothers with sufficient prenatal 25(OH)D levels. The potential mechanism of action of di(2-ethylhexyl) phthalate (DEHP) exposure may involve affecting GRIN2B, inhibiting NMDAR in the postsynaptic membrane, disrupting synaptic function, and impairing learning and memory, ultimately leading to ASD development. Importantly, maternal vitamin D supplementation was demonstrated to mitigate the risk of ASD associated with phthalate exposure. Reducing phthalate exposure during pregnancy may be associated with a decreased risk of autistic traits in children. Furthermore, adequate vitamin D supplementation could potentially mitigate the impact of phthalates on these traits. Additionally, the proposed biological mechanism provides insight into how phthalate exposure may contribute to the development of ASD.

产前接触邻苯二甲酸盐混合物与儿童自闭症谱系障碍（ASD）风险之间的关系以及母体维生素 D 的潜在机制和影响仍不清楚。我们分析了 3209 对母子的数据。我们探讨了产前邻苯二甲酸盐暴露与 1.5、3、5 和 6 岁儿童自闭症特征之间的关联。此外，还估算了母体维生素 D 和不良后果途径的调节作用，从而阐明了邻苯二甲酸盐对自闭症的影响。接触邻苯二甲酸盐混合物与1.5-6岁儿童患ASD的风险增加有关。对于缺乏 25(OH)D 的母亲来说，在孕早期至孕中期接触邻苯二甲酸盐混合物与 3 岁儿童的自闭症特征之间存在暴露-反应关系。然而，产前 25（OH）D 水平充足的母亲则没有观察到这种关系。接触邻苯二甲酸二（2-乙基己基）酯（DEHP）的潜在作用机制可能包括影响GRIN2B，抑制突触后膜上的NMDAR，破坏突触功能，损害学习和记忆，最终导致自闭症的发展。重要的是，母体补充维生素 D 被证明可降低与邻苯二甲酸盐暴露相关的 ASD 风险。减少孕期接触邻苯二甲酸盐可能与降低儿童患自闭症的风险有关。此外，补充充足的维生素 D 有可能减轻邻苯二甲酸盐对这些特征的影响。此外，所提出的生物学机制还有助于人们深入了解接触邻苯二甲酸盐是如何导致自闭症的发展的。

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引用次数: 0

From submission to publication: An editor's perspective on why Eco-Environment & Health stands out 从投稿到发表：从编辑的角度看为什么生态环境与健康脱颖而出。

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1016/j.eehl.2024.11.001

Li Li

引用次数: 0

Styrene and ethylbenzene exposure and type 2 diabetes mellitus: A longitudinal gene–environment interaction study 苯乙烯和乙苯暴露与 2 型糖尿病：基因与环境相互作用的纵向研究

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-08-12 DOI: 10.1016/j.eehl.2024.07.001

Linling Yu , Wei Liu , Yongfang Zhang , Qiyou Tan , Jiahao Song , Lieyang Fan , Xiaojie You , Min Zhou , Bin Wang , Weihong Chen

Styrene and ethylbenzene (S/EB) are identified as hazardous air contaminants that raise significant concerns. The association between S/EB exposure and the incidence of type 2 diabetes mellitus (T2DM), and the interaction between genes and environment, remains poorly understood. Our study consisted of 2219 Chinese adults who were part of the Wuhan-Zhuhai cohort. A follow-up assessment was conducted after six years. Exposure to S/EB was quantified by determining the concentrations of urinary biomarkers of exposure to S/EB (UBE-S/EB; urinary phenylglyoxylic acid level plus urinary mandelic acid level). Logistic regression models were constructed to investigate the relations of UBE-S/EB and genetic risk score (GRS) with T2DM prevalence and incidence. The interaction effects of UBE-S/EB and GRS on T2DM were investigated on multiplicative and additive scales. UBE-S/EB was dose-dependently and positively related to T2DM prevalence and incidence. Participants with high levels of UBE-S/EB [relative risk (RR) = 1.930, 95% confidence interval (CI): 1.157–3.309] or GRS (1.943, 1.110–3.462) demonstrated the highest risk of incident T2DM, in comparison to those with low levels of UBE-S/EB or GRS. Significant additive interaction between UBE-S/EB and GRS on T2DM incidence was discovered with relative excess risk due to interaction (95% CI) of 0.178 (0.065–0.292). The RR (95% CI) of T2DM incidence was 2.602 (1.238–6.140) for individuals with high UBE-S/EB and high GRS, compared to those with low UBE-S/EB and low GRS. This study presented the initial evidence that S/EB exposure was significantly related to increased risk of T2DM incidence, and the relationship was interactively aggravated by genetic predisposition.

苯乙烯和乙基苯（S/EB）被认为是引起严重关注的有害空气污染物。人们对苯乙烯和乙苯（S/EB）暴露与 2 型糖尿病（T2DM）发病率之间的关系以及基因和环境之间的相互作用仍然知之甚少。我们的研究包括武汉-珠海队列中的 2219 名中国成年人。六年后进行了一次随访评估。通过测定尿液中暴露于 S/EB 的生物标志物（UBE-S/EB；尿液苯乙酸水平加尿液扁桃酸水平）的浓度，量化了 S/EB 暴露。为研究 UBE-S/EB 和遗传风险评分（GRS）与 T2DM 患病率和发病率的关系，建立了逻辑回归模型。研究了 UBE-S/EB 和 GRS 对 T2DM 的乘法和加法交互效应。UBE-S/EB 与 T2DM 患病率和发病率呈剂量依赖性正相关。与 UBE-S/EB 或 GRS 水平低的参与者相比，UBE-S/EB 水平高的参与者[相对风险 (RR) = 1.930，95% 置信区间 (CI)：1.157-3.309]或 GRS (1.943, 1.110-3.462)发生 T2DM 的风险最高。研究发现，UBE-S/EB 和 GRS 对 T2DM 发病率有显著的相加作用，相互作用导致的相对超额风险（95% CI）为 0.178（0.065-0.292）。与低 UBE-S/EB 和低 GRS 的人群相比，高 UBE-S/EB 和高 GRS 的人群 T2DM 发病率的 RR（95% CI）为 2.602（1.238-6.140）。这项研究提供了初步证据，表明 S/EB 暴露与 T2DM 发病风险的增加有显著关系，而遗传易感性会交互加重这种关系。

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引用次数: 0

Piezocatalytic techniques and materials for degradation of organic pollutants from aqueous solution 用于降解水溶液中有机污染物的压电催化技术和材料

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-08-22 DOI: 10.1016/j.eehl.2024.08.001

Bo Liu , Xiaolu Liu , Yang Li , Muliang Xiao , Zhongshan Chen , Suhua Wang , Hongqing Wang , Xiangke Wang

With the rapid development of industry, agriculture, and urbanization, various organic pollutants have accumulated in natural water, posing a potential threat to both the ecological environment and human beings, and removing organic pollutants from water is an urgent priority. Piezoelectric techniques, with the advantages of green, simple operation, and high efficiency, are highly sought after in the degradation of environmental organic pollutants. Moreover, combining piezoelectric techniques with advanced oxidation processes (AOPs), photocatalysis, or electrocatalysis can further effectively promote the efficient degradation of target pollutants. Therefore, a perspective is presented on the recent progress of piezoelectric techniques for the degradation of various organic pollutants from aqueous solutions. The classification of various piezoelectric materials, as well as modification strategies for improving piezocatalysis, are first systematically summarized. Furthermore, the latest research on piezocatalysis and its combination with other technologies, such as AOPs, photocatalysis, and electrocatalysis, in the degradation of environmental pollutants is discussed. The potential mechanisms of piezocatalysis are also analyzed in depth. Finally, the urgent challenges and future opportunities for piezoelectric techniques in the degradation of organic pollutants are provided.

随着工业、农业和城市化的快速发展，天然水中积累了各种有机污染物，对生态环境和人类都构成了潜在威胁，去除水中的有机污染物已成为当务之急。压电技术具有绿色环保、操作简单、效率高等优点，在降解环境有机污染物方面备受青睐。此外，将压电技术与高级氧化过程（AOPs）、光催化或电催化相结合，可进一步有效促进目标污染物的高效降解。因此，本文介绍了压电技术在降解水溶液中各种有机污染物方面的最新进展。首先系统地总结了各种压电材料的分类以及改善压电催化的改性策略。此外，还讨论了有关压电催化及其与其他技术（如 AOP、光催化和电催化）在降解环境污染物方面结合的最新研究。此外，还深入分析了压电催化的潜在机制。最后，介绍了压电技术在降解有机污染物方面面临的紧迫挑战和未来机遇。

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引用次数: 0

Atmospheric Hg(0) dry deposition over environmental surfaces: Insights from mercury isotope fractionation 环境表面的大气汞（0）干沉积：汞同位素分馏的启示

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-05-09 DOI: 10.1016/j.eehl.2024.04.009

Yanwei Liu , Hongwei Liu , Yingying Guo , Dawei Lu , Xingwang Hou , Jianbo Shi , Yongguang Yin , Yong Cai , Guibin Jiang

Atmospheric Hg(0) dry deposition is a vital process that significantly affects the global distribution and cycling of Hg. However, significant knowledge gaps and challenges remain in understanding atmospheric Hg(0) deposition and its subsequent post-deposition processes. Hg isotope fractionation has emerged as the most powerful tool for evaluating the impact of atmospheric Hg(0) deposition and unraveling key processes associated with it. By focusing on Hg isotope fractionation processes, Hg isotopic compositions, and influencing factors, this review presents current knowledge, recent advances, and new insights into atmospheric Hg(0) deposition and post-deposition processes over vegetation, soil, snow, and water surfaces. This review also points out the knowledge gaps pertaining to atmospheric Hg(0) deposition and highlights the need for further investigation into the associated processes, mechanisms, isotope fractionation, and modeling. Further research into Hg isotope fractionation in atmospheric Hg(0) deposition and post-deposition processes will advance source and process tracing, paleoclimate reconstruction, and the modeling of Hg isotope distribution on regional and global scales.

大气中的汞（0）干沉积是一个重要过程，对汞的全球分布和循环有重大影响。然而，在了解大气汞（0）沉积及其后续沉积后过程方面仍存在巨大的知识差距和挑战。汞同位素分馏已成为评估大气汞沉积影响和揭示相关关键过程的最有力工具。本综述以汞同位素分馏过程、汞同位素组成和影响因素为重点，介绍了有关大气中汞（0）沉积以及植被、土壤、雪和水面沉积后过程的现有知识、最新进展和新见解。本综述还指出了与大气汞沉积有关的知识空白，并强调了进一步研究相关过程、机制、同位素分馏和建模的必要性。对大气汞（0）沉积和沉积后过程中汞同位素分馏的进一步研究将推动来源和过程追踪、古气候重建以及区域和全球范围内汞同位素分布的建模。

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引用次数: 0

In situ imaging of microplastics in living organisms based on mass spectrometry technology 基于质谱技术的生物体内微塑料原位成像技术

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-06-26 DOI: 10.1016/j.eehl.2024.05.007

Ye Li , Xiaoyu Sha , Yuan Wang , Yanfang Zhao , Junjie Zhang , Ping Wang , Xiangfeng Chen , Baoshan Xing , Lei Wang

Plastic pollution is widely present in terrestrial and aquatic ecosystems, and microplastics (MPs) can be detected in organisms. In situ detection methods for MPs in organisms have attracted widespread attention. Traditional imaging characterization methods of MPs, including stereo microscopes and fluorescence microscopy, are typically used to image artificially added microsphere standards under laboratory conditions. However, they cannot specifically identify MPs in biological samples. Thus, there is a need for a detection technique that can provide spatial distribution information of MPs in biological samples as well as measure their quality and quantity. In this perspective, to obtain high-resolution images with chemical composition analysis, we compared ion sources for ionizing plastic macromolecules and mass analyzers for analyzing macromolecules. Matrix-assisted laser desorption/ionization (MALDI) is suitable for imaging characterization, while time-of-flight (TOF) and Orbitrap mass spectrometry are suitable for polymer mass spectrometry analysis. Furthermore, we propose a technique that combines MALDI with TOF or Orbitrap, which holds promise for the in situ imaging of MPs in biological samples.

塑料污染广泛存在于陆地和水生生态系统中，生物体内可以检测到微塑料（MPs）。生物体内 MPs 的原位检测方法已引起广泛关注。传统的 MPs 成像表征方法，包括立体显微镜和荧光显微镜，通常用于在实验室条件下对人工添加的微球标准进行成像。然而，这些方法无法特异性地识别生物样本中的 MPs。因此，需要一种既能提供生物样本中微球的空间分布信息，又能测量其质量和数量的检测技术。从这个角度出发，为了获得具有化学成分分析功能的高分辨率图像，我们对用于电离塑料大分子的离子源和用于分析大分子的质量分析仪进行了比较。基质辅助激光解吸/电离（MALDI）适用于成像表征，而飞行时间（TOF）和 Orbitrap 质谱仪则适用于聚合物质谱分析。此外，我们还提出了一种将 MALDI 与 TOF 或 Orbitrap 相结合的技术，有望用于生物样品中 MPs 的原位成像。

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引用次数: 0

Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review 全氟和多氟烷基物质神经毒性的不良后果途径：系统综述

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-08-30 DOI: 10.1016/j.eehl.2024.08.002

Shenpan Li , Shuangjian Qin , Huixian Zeng , Weichun Chou , Anna Oudin , Katja M. Kanninen , Pasi Jalava , Guanghui Dong , Xiaowen Zeng

Per- and polyfluoroalkyl substances (PFAS) are endocrine disruptors with unambiguous neurotoxic effects. However, due to variability in experimental models, population characteristics, and molecular endpoints, the elucidation of mechanisms underlying PFAS-induced neurotoxicity remains incomplete. In this review, we utilized the adverse outcome pathway (AOP) framework, a comprehensive tool for evaluating toxicity across multiple biological levels (molecular, cellular, tissue and organ, individual, and population), to elucidate the mechanisms of neurotoxicity induced by PFAS. Based on 271 studies, the reactive oxygen species (ROS) generation emerged as the molecular initiating event 1 (MIE1). Subsequent key events (KEs) at the cellular level include oxidative stress, neuroinflammation, apoptosis, altered Ca²⁺ signal transduction, glutamate and dopamine signaling dyshomeostasis, and reduction of cholinergic and serotonin. These KEs culminate in synaptic dysfunction at organ and tissue levels. Further insights were offered into MIE2 and upstream KEs associated with altered thyroid hormone levels, contributing to synaptic dysfunction and hypomyelination at the organ and tissue levels. The inhibition of Na⁺/I⁻ symporter (NIS) was identified as the MIE2, initiating a cascade of KEs at the cellular level, including altered thyroid hormone synthesis, thyroid hormone transporters, thyroid hormone metabolism, and binding with thyroid hormone receptors. All KEs ultimately result in adverse outcomes (AOs), including cognition and memory impairment, autism spectrum disorders, attention deficit hyperactivity disorders, and neuromotor development impairment. To our knowledge, this review represents the first comprehensive and systematic AOP analysis delineating the intricate mechanisms responsible for PFAS-induced neurotoxic effects, providing valuable insights for risk assessments and mitigation strategies against PFAS-related health hazards.

全氟烷基和多氟烷基物质（PFAS）是一种内分泌干扰物，具有明确的神经毒性作用。然而，由于实验模型、人群特征和分子终点的差异，对全氟辛烷磺酸诱导神经毒性机制的阐明仍不完整。在本综述中，我们采用了不良后果途径（AOP）框架来阐明全氟辛烷磺酸诱导神经毒性的机制。该框架是一种评估多个生物水平（分子、细胞、组织和器官、个体和人群）毒性的综合工具。在 271 项研究的基础上，活性氧 (ROS) 的生成成为分子起始事件 1 (MIE1)。细胞水平的后续关键事件（KEs）包括氧化应激、神经炎症、细胞凋亡、Ca2+ 信号转导改变、谷氨酸和多巴胺信号失衡以及胆碱能和血清素减少。这些 KEs 最终导致器官和组织水平的突触功能障碍。研究还进一步揭示了与甲状腺激素水平改变相关的MIE2和上游KEs，这些KEs在器官和组织水平上导致了突触功能障碍和髓鞘功能减退。Na+/I-交感器（NIS）的抑制被确定为MIE2，它在细胞水平启动了一连串的KEs，包括甲状腺激素合成、甲状腺激素转运体、甲状腺激素代谢以及与甲状腺激素受体结合的改变。所有KEs最终都会导致不良后果（AOs），包括认知和记忆障碍、自闭症谱系障碍、注意缺陷多动障碍和神经运动发育障碍。据我们所知，本综述是首次对 AOP 进行全面、系统的分析，描述了全氟辛烷磺酸诱发神经毒性效应的复杂机制，为针对全氟辛烷磺酸相关健康危害的风险评估和缓解策略提供了宝贵的见解。

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引用次数: 0

Long-term exposure to air pollution and incidence risk of various arrhythmias: A prospective cohort study 长期暴露于空气污染与各种心律失常的发病风险：一项前瞻性队列研究

Eco-Environment & Health

Pub Date : 2024-12-01 Epub Date: 2024-06-11 DOI: 10.1016/j.eehl.2024.05.006

To investigate the association of long-term exposure to air pollution with incident arrhythmia from various causes, this prospective cohort study included 442,386 participants from the UK Biobank cohort. Residential annual average exposures at baseline were evaluated, including fine particles (PM_2.5), coarse particles (PM_2.5–10), nitrogen dioxide (NO₂), and nitrogen oxides (NO_x). We further constructed a composite air pollution score (APS) to evaluate the concomitant exposure to these four pollutants. The associations of air pollutants with various arrhythmia subtypes were assessed utilizing the Cox proportional hazards model, and the hazard ratios (HRs) for incident arrhythmias were estimated. A total of 41,021 patients with incident arrhythmia were recorded. The HRs of overall arrhythmia associated with a 10 μg/m³ increment in PM_2.5, PM_2.5–10, NO₂, and NO_x were 1.26, 0.95, 1.03, and 1.02, respectively. The HR was 1.08 in the highest quintile of the APS compared to the lowest one. For cause-specific arrhythmias, the HRs per unit increment in APS were 1.45, 1.67, 1.51, 1.80, 2.63, and 4.66 for atrial fibrillation, atrioventricular block, ventricular fibrillation/tachycardia, intraventricular block, supraventricular tachycardia, and ventricular premature beats, respectively. Females, older individuals, overweight or obese individuals, and those with low education attainment, low income, or cardiometabolic morbidities had higher HRs associated with pollutants. Long-term exposure to air pollution is linked to increased incidence risks of atrial and ventricular arrhythmias. More focus should be shifted to the impact of air pollution on other arrhythmias besides atrial fibrillation.

为了研究长期暴露于空气污染与各种原因引起的心律失常之间的关系，这项前瞻性队列研究纳入了英国生物库队列中的 442386 名参与者。我们评估了基线时的住宅年平均暴露量，包括细颗粒物（PM2.5）、粗颗粒物（PM2.5-10）、二氧化氮（NO2）和氮氧化物（NOx）。我们进一步构建了空气污染综合评分（APS），以评估同时暴露于这四种污染物的情况。我们利用 Cox 比例危险模型评估了空气污染物与各种心律失常亚型之间的关系，并估算了心律失常发病的危险比 (HR)。共记录了 41,021 名心律失常患者。PM2.5、PM2.5-10、二氧化氮和氮氧化物每增加 10 μg/m3，总体心律失常的危险比分别为 1.26、0.95、1.03 和 1.02。与最低值相比，APS 最高五分位数的心率为 1.08。就特定病因的心律失常而言，心房颤动、房室传导阻滞、心室颤动/心动过速、室内传导阻滞、室上性心动过速和室性早搏的 APS 每单位增量的 HR 分别为 1.45、1.67、1.51、1.80、2.63 和 4.66。女性、老年人、超重或肥胖者以及受教育程度低、收入低或患有心脏代谢疾病的人与污染物相关的心率较高。长期暴露于空气污染与房性和室性心律失常发病风险的增加有关。除心房颤动外，还应更加关注空气污染对其他心律失常的影响。

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引用次数: 0