Pub Date : 2022-01-01DOI: 10.23736/s2784-8477.21.01978-1
Gonzalo SEGRELLES CALVO, Estefanía Llopis Pastor, E. Antón, I. Escribano, L. Rey, Mercedes GARCÍA-SALAMONES
{"title":"Pneumonia due to Kocuria kristinae in patient with severe chronic pulmonary obstructive disease: first case in Europe","authors":"Gonzalo SEGRELLES CALVO, Estefanía Llopis Pastor, E. Antón, I. Escribano, L. Rey, Mercedes GARCÍA-SALAMONES","doi":"10.23736/s2784-8477.21.01978-1","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01978-1","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"122 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81708249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.23736/s2784-8477.21.01982-3
P. Paliogiannis, A. Zinellu, A. Mangoni, A. Pazzola, F. Bandiera, A. Spanó, Chiara Sanna, Valentina Scano, S. S. Fois, Verdiana Muscas, Elena Masotto, S. Dore, V. Fiore, P. Pirina, C. Carru, A. Fois
BACKGROUND: Blood coagulation alterations are frequent in patients with Coronavirus disease 2019 (COVID-19), particularly in those with severe forms. We investigated the association between standard parameters of coagulation and in-hospital mortality in COVID-19. METHODS: Demographic, clinical and laboratory data at hospital admission, including prothrombin time (PT), international normalized rate (INR), activated thromboplastin time (aPTT), and D-dimer were retrospectively collected in a consecutive series of 309 COVID-19 hospitalized patients. The associations between parameters of coagulation and in-hospital mortality were investigated with receiver operating characteristics (ROC), multiple regression and Kaplan- Meyer analyses. RESULTS: In the overall population, 220 (71.2%) patients were discharged alive, whereas the remaining 89 (28.8%) died. Non-survivors had significantly higher INR (median: 1.20;IQR: 1.03-1.32 vs. 1.06;IQR: 1.02-1.11, P<0.001), PT (median: 12.0 sec;IQR: 11.1-14.0 vs. 11.4 sec;IQR: 11.0-11.9, P<0.001), aPTT (median: 25.1 sec;IQR: 22.7-29.6 vs. 23.4 sec;IQR: 21.4-25.1, P<0.001) and D-dimer (median: 1.36 μg/mL;IQR: 0.87-4.11 vs. 0.77 μg/mL;IQR: 0.43-1.58, P<0.001). In multivariate Cox regression analysis, both the INR (HR=1.8459;95% CI: 1.0713-3.1806, P=0.027) and PT (HR=1.071;95% CI: 1.0132-1.1303, P=0.015), but not the aPTT and D-dimer, remained independently associated with survival. CONCLUSIONS: Both the PTand INRare independently associated with in-hospital mortality in COVID-19. The clinical utility of these parameters for risk stratification warrants further investigations.
背景:2019冠状病毒病(COVID-19)患者常发生凝血改变，尤其是重症患者。我们调查了COVID-19患者凝血标准参数与住院死亡率之间的关系。方法:回顾性收集309例新冠肺炎住院患者入院时的人口学、临床和实验室资料，包括凝血酶原时间(PT)、国际标准化率(INR)、活化凝血活酶时间(aPTT)和d -二聚体。采用受试者工作特征(ROC)、多元回归和Kaplan- Meyer分析探讨凝血指标与住院死亡率的关系。结果:在总体人群中，220例(71.2%)患者存活出院，89例(28.8%)患者死亡。非幸存者的INR(中位数:1.20;IQR: 1.03-1.32 vs. 1.06;IQR: 1.02-1.11, P<0.001)、PT(中位数:12.0秒;IQR: 11.1-14.0 vs. 11.4秒;IQR: 11.0-11.9, P<0.001)、aPTT(中位数:25.1秒;IQR: 22.7-29.6 vs. 23.4秒;IQR: 21.4-25.1, P<0.001)和d -二聚体(中位数:1.36 μg/mL;IQR: 0.87-4.11 vs. 0.77 μg/mL;IQR: 0.43-1.58, P<0.001)均显著升高。在多变量Cox回归分析中，INR (HR=1.8459, 95% CI: 1.0713-3.1806, P=0.027)和PT (HR=1.071, 95% CI: 1.0132-1.1303, P=0.015)仍然与生存率独立相关，但aPTT和d -二聚体与生存率无关。结论:pti和INRare均与COVID-19住院死亡率独立相关。这些风险分层参数的临床应用值得进一步研究。
{"title":"Prothrombin time (PT), international normalized rate (INR), and in-hospital mortality in COVID-19","authors":"P. Paliogiannis, A. Zinellu, A. Mangoni, A. Pazzola, F. Bandiera, A. Spanó, Chiara Sanna, Valentina Scano, S. S. Fois, Verdiana Muscas, Elena Masotto, S. Dore, V. Fiore, P. Pirina, C. Carru, A. Fois","doi":"10.23736/s2784-8477.21.01982-3","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01982-3","url":null,"abstract":"BACKGROUND: Blood coagulation alterations are frequent in patients with Coronavirus disease 2019 (COVID-19), particularly in those with severe forms. We investigated the association between standard parameters of coagulation and in-hospital mortality in COVID-19. METHODS: Demographic, clinical and laboratory data at hospital admission, including prothrombin time (PT), international normalized rate (INR), activated thromboplastin time (aPTT), and D-dimer were retrospectively collected in a consecutive series of 309 COVID-19 hospitalized patients. The associations between parameters of coagulation and in-hospital mortality were investigated with receiver operating characteristics (ROC), multiple regression and Kaplan- Meyer analyses. RESULTS: In the overall population, 220 (71.2%) patients were discharged alive, whereas the remaining 89 (28.8%) died. Non-survivors had significantly higher INR (median: 1.20;IQR: 1.03-1.32 vs. 1.06;IQR: 1.02-1.11, P<0.001), PT (median: 12.0 sec;IQR: 11.1-14.0 vs. 11.4 sec;IQR: 11.0-11.9, P<0.001), aPTT (median: 25.1 sec;IQR: 22.7-29.6 vs. 23.4 sec;IQR: 21.4-25.1, P<0.001) and D-dimer (median: 1.36 μg/mL;IQR: 0.87-4.11 vs. 0.77 μg/mL;IQR: 0.43-1.58, P<0.001). In multivariate Cox regression analysis, both the INR (HR=1.8459;95% CI: 1.0713-3.1806, P=0.027) and PT (HR=1.071;95% CI: 1.0132-1.1303, P=0.015), but not the aPTT and D-dimer, remained independently associated with survival. CONCLUSIONS: Both the PTand INRare independently associated with in-hospital mortality in COVID-19. The clinical utility of these parameters for risk stratification warrants further investigations.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88767287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.23736/s2784-8477.21.01932-5
A. Zinellu, Valentina Scano, Elena Masotto, G. De Riu, L. Vaira, C. Carru, P. Pirina, S. Babudieri, A. Mangoni, A. Fois
BACKGROUND: The early detection of factors predicting hospital length of stay (LOS) in patients affected by severe acute respiratory syndrome in Coronavirus 2 (SARS-CoV-2) disease (COVID-19) might facilitate therapeutic decisions and patient flow management. METHODS: We collected routine clinical and laboratory parameters and derived inflammatory indexes on admission in 65 consecutive COVID-19 patients transferred to the Unit of Respiratory and Infectious Disease of the University Hospital of Sassari (North-Sardinia, Italy) who were alive on discharge. RESULTS: Patients with prolonged length of stay (LOS) (PLOS >= 26 days, N.=22) had significantly higher chest CT severity scores, neutrophils, neutrophil lymphocyte ratio (NLR), aggregate index of systemic inflammation, Systemic Inflammation Response Index, Systemic Inflammation Index (SII), aspartate aminotransferase, lactate dehydrogenase (LDH), and rates of obesity and respiratory support, than non-PLOS patients (N.=43). In univariate analysis, LOS was significantly and negatively correlated with lymphocytes and monocytes, and positively correlated with Body Mass Index (BMI), intensity of care, chest CT severity score, NLR, platelet lymphocyte ratio, SII and LDH. In multivariate regression analysis, only the SII was significantly associated with LOS (beta=0.506, P=0.002) after adjusting for BMI, intensity of care, chest CT severity score and LDH. CONCLUSIONS: SII values on admission were independently associated with LOS in COVID-19 patients. Prospective studies in larger cohorts are required to confirm our findings and to determine the role of the SII in clinical decision making.
{"title":"The Systemic Inflammation Index on admission is independently associated with length of stay in hospitalized COVID-19 patients","authors":"A. Zinellu, Valentina Scano, Elena Masotto, G. De Riu, L. Vaira, C. Carru, P. Pirina, S. Babudieri, A. Mangoni, A. Fois","doi":"10.23736/s2784-8477.21.01932-5","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01932-5","url":null,"abstract":"BACKGROUND: The early detection of factors predicting hospital length of stay (LOS) in patients affected by severe acute respiratory syndrome in Coronavirus 2 (SARS-CoV-2) disease (COVID-19) might facilitate therapeutic decisions and patient flow management. METHODS: We collected routine clinical and laboratory parameters and derived inflammatory indexes on admission in 65 consecutive COVID-19 patients transferred to the Unit of Respiratory and Infectious Disease of the University Hospital of Sassari (North-Sardinia, Italy) who were alive on discharge. RESULTS: Patients with prolonged length of stay (LOS) (PLOS >= 26 days, N.=22) had significantly higher chest CT severity scores, neutrophils, neutrophil lymphocyte ratio (NLR), aggregate index of systemic inflammation, Systemic Inflammation Response Index, Systemic Inflammation Index (SII), aspartate aminotransferase, lactate dehydrogenase (LDH), and rates of obesity and respiratory support, than non-PLOS patients (N.=43). In univariate analysis, LOS was significantly and negatively correlated with lymphocytes and monocytes, and positively correlated with Body Mass Index (BMI), intensity of care, chest CT severity score, NLR, platelet lymphocyte ratio, SII and LDH. In multivariate regression analysis, only the SII was significantly associated with LOS (beta=0.506, P=0.002) after adjusting for BMI, intensity of care, chest CT severity score and LDH. CONCLUSIONS: SII values on admission were independently associated with LOS in COVID-19 patients. Prospective studies in larger cohorts are required to confirm our findings and to determine the role of the SII in clinical decision making.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"29 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91190994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.23736/s2784-8477.20.01901-x
S. Duarte, D. Sousa, Catarina Jorge
{"title":"Aspergilloma: beyond a pneumonia, when the symptoms persist","authors":"S. Duarte, D. Sousa, Catarina Jorge","doi":"10.23736/s2784-8477.20.01901-x","DOIUrl":"https://doi.org/10.23736/s2784-8477.20.01901-x","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"24 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83221733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.23736/s2784-8477.21.01915-5
A. Lobanov, A. Fesyun, A. Voronenko, S. Andronov, M. Yakovlev, A. P. Rachin, U. Solimene, A. Nikitina, A. Zaitsev, V. Kochetkova, G. Barashkov, E.E. Mitroshkina, A. I. Zharkov, T. Konchugova, I. Grishechkina, Luo Ying, E. Bogdanova, M. Eremushkin, Tatiana R. Saganova, I. Reverchuk, A. Zuev
{"title":"The application of mineral water in the treatment of chronic obstructive pulmonary disease: a meta-analysis","authors":"A. Lobanov, A. Fesyun, A. Voronenko, S. Andronov, M. Yakovlev, A. P. Rachin, U. Solimene, A. Nikitina, A. Zaitsev, V. Kochetkova, G. Barashkov, E.E. Mitroshkina, A. I. Zharkov, T. Konchugova, I. Grishechkina, Luo Ying, E. Bogdanova, M. Eremushkin, Tatiana R. Saganova, I. Reverchuk, A. Zuev","doi":"10.23736/s2784-8477.21.01915-5","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01915-5","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79247520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.23736/s2784-8477.21.01919-2
F. Gavelli, E. Gattoni, Giulia Statti, D. Azzolina, Elisa Maggi, F. Patrucco, P. Sainaghi, G. Avanzi, P. Zeppegno, Luigi Castello
{"title":"High-flow nasal cannula in the treatment of acute carbon monoxide poisoning: a pilot study","authors":"F. Gavelli, E. Gattoni, Giulia Statti, D. Azzolina, Elisa Maggi, F. Patrucco, P. Sainaghi, G. Avanzi, P. Zeppegno, Luigi Castello","doi":"10.23736/s2784-8477.21.01919-2","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01919-2","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"17 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87859825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.23736/s2784-8477.21.01936-2
P. Ferrara, Diletta Saitta, Giulia Franceschini, Martina Vecchio, Chiara DE LISO, D. Grasso, F. Baldo, A. Ianni, M. Villa
{"title":"The role of myofunctional therapy in the treatment of enuretic children with sleep-disordered breathing","authors":"P. Ferrara, Diletta Saitta, Giulia Franceschini, Martina Vecchio, Chiara DE LISO, D. Grasso, F. Baldo, A. Ianni, M. Villa","doi":"10.23736/s2784-8477.21.01936-2","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01936-2","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89244705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.23736/s2784-8477.21.01933-7
F. Cavalli, E. Puxeddu, Elisa Teodori, Maurizia Sforza, Patrizia de Marco, P. Rogliani
{"title":"Biomarkers for possible early detection and progression of idiopathic pulmonary fibrosis","authors":"F. Cavalli, E. Puxeddu, Elisa Teodori, Maurizia Sforza, Patrizia de Marco, P. Rogliani","doi":"10.23736/s2784-8477.21.01933-7","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01933-7","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"85 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90167921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-01DOI: 10.23736/S2784-8477.20.01900-8
F. Sanguedolce, M. Zanelli, S. Ascani, M. Zizzo, S. Tortorella, A. Soriano, A. Fiorelli, G. Cocco, Nicla Ardò, F. Sollitto, D. Loizzi
{"title":"PD-L1 as a prognostic and predictive biomarker in neuroendocrine tumors of the lung: state of the art and future perspectives","authors":"F. Sanguedolce, M. Zanelli, S. Ascani, M. Zizzo, S. Tortorella, A. Soriano, A. Fiorelli, G. Cocco, Nicla Ardò, F. Sollitto, D. Loizzi","doi":"10.23736/S2784-8477.20.01900-8","DOIUrl":"https://doi.org/10.23736/S2784-8477.20.01900-8","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87777427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-01DOI: 10.23736/s0026-4954.19.01863-7
F. Gavelli, F. Patrucco, Matteo Daverio, N. De Vita, M. Bellan, O. Rena, P. Balbo, G. Avanzi, L. Castello
{"title":"Sequelae of traumatic rib fractures: management in the Emergency Department","authors":"F. Gavelli, F. Patrucco, Matteo Daverio, N. De Vita, M. Bellan, O. Rena, P. Balbo, G. Avanzi, L. Castello","doi":"10.23736/s0026-4954.19.01863-7","DOIUrl":"https://doi.org/10.23736/s0026-4954.19.01863-7","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"31 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75575602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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