Pub Date : 2023-09-01Epub Date: 2023-09-12DOI: 10.1089/bioe.2023.0025
Jose F Ek-Vitorin, Jean X Jiang
Mutations of lens connexins are linked to congenital cataracts. However, the role of connexin mutations in the development of age-related lens opacification remains largely unknown. Here, we present a focused review of the literature on lens organization and factors associated with cataract development. Several lines of evidence indicate that disturbances of the lens circulation by dysfunctional connexin channels, and/or accumulation of protein damage due to oxidative stress, are key factors in cataract development. Phosphorylation by protein kinase A improves the permeability of connexins channels to small molecules and mitigates the lens clouding induced by oxidative stress. We conclude (1) that connexin channels are central to the lens circulation and (2) that their permeability to antioxidant molecules contributes to the maintenance of lens transparency.
{"title":"The Role of Gap Junctions Dysfunction in the Development of Cataracts: From Loss of Cell-to-Cell Transfer to Blurred Vision-Review.","authors":"Jose F Ek-Vitorin, Jean X Jiang","doi":"10.1089/bioe.2023.0025","DOIUrl":"10.1089/bioe.2023.0025","url":null,"abstract":"<p><p>Mutations of lens connexins are linked to congenital cataracts. However, the role of connexin mutations in the development of age-related lens opacification remains largely unknown. Here, we present a focused review of the literature on lens organization and factors associated with cataract development. Several lines of evidence indicate that disturbances of the lens circulation by dysfunctional connexin channels, and/or accumulation of protein damage due to oxidative stress, are key factors in cataract development. Phosphorylation by protein kinase A improves the permeability of connexins channels to small molecules and mitigates the lens clouding induced by oxidative stress. We conclude (1) that connexin channels are central to the lens circulation and (2) that their permeability to antioxidant molecules contributes to the maintenance of lens transparency.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"5 3","pages":"164-172"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Interview with Sally Adee, the Author of the Book “We Are Electric”","authors":"M. Djamgoz","doi":"10.1089/bioe.2023.0031","DOIUrl":"https://doi.org/10.1089/bioe.2023.0031","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"18 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89781781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amanda Foust, Peter Quicke, Yilin Sun, C. Bakal, M. Djamgoz
{"title":"Voltage-Sensitive Optical Probes for Measuring Cell Membrane Potentials: An Update and Applications to “Nonexcitable” Cells","authors":"Amanda Foust, Peter Quicke, Yilin Sun, C. Bakal, M. Djamgoz","doi":"10.1089/bioe.2022.0034","DOIUrl":"https://doi.org/10.1089/bioe.2022.0034","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"18 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80082577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Vivo Measurement of Voltage and Resistance in Fractured Human Bone: A Pilot Study","authors":"Navid Ziran, N. Attias","doi":"10.1089/bioe.2022.0039","DOIUrl":"https://doi.org/10.1089/bioe.2022.0039","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"2 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76183393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the Oligomerization of Nav1.5 and Its Implication for the Dominant-Negative Effect","authors":"O. Iamshanova, J. Rougier, Hugues Abriel","doi":"10.1089/bioe.2023.0014","DOIUrl":"https://doi.org/10.1089/bioe.2023.0014","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"140 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76591155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioelectricity: A Top-Down Control Model to Promote More Effective Aging Interventions","authors":"Benjamin Anderson","doi":"10.1089/bioe.2023.0013","DOIUrl":"https://doi.org/10.1089/bioe.2023.0013","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"90 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78453103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrical Signals in Systemic Adaptive Response of Higher Plants: Integration Through Separation","authors":"E. Sukhova, V. Sukhov","doi":"10.1089/bioe.2022.0042","DOIUrl":"https://doi.org/10.1089/bioe.2022.0042","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"38 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88923719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Memoriam: Lawrence B. Cohen (1939–2023)","authors":"Amanda Foust","doi":"10.1089/bioe.2023.0020","DOIUrl":"https://doi.org/10.1089/bioe.2023.0020","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"13 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77084007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioelectricityVol. 5, No. 2 Bioelectricity BuzzBioelectricity BuzzAnn M. RajnicekAnn M. RajnicekAnn M. Rajnicek, BS, PhD, FRSB, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, AB25 2ZD Aberdeen, United Kingdom E-mail Address: [email protected]Search for more papers by this authorPublished Online:16 Jun 2023https://doi.org/10.1089/bioe.2023.0021AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetails Volume 5Issue 2Jun 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Ann M. Rajnicek.Bioelectricity Buzz.Bioelectricity.Jun 2023.139-146.http://doi.org/10.1089/bioe.2023.0021Published in Volume: 5 Issue 2: June 16, 2023PDF download
BioelectricityVol。5、No. 2 Bioelectricity BuzzBioelectricity BuzzAnn M. RajnicekAnn M. RajnicekAnn M. Rajnicek，学士，博士，FRSB，阿伯丁大学医学院，医学科学与营养研究所，AB25 2ZD阿伯丁，英国[email protected]搜索本文作者的更多论文出版在线:2023年6月16日https://doi.org/10.1089/bioe.2023.0021AboutSectionsView articleView全文pdf /EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites返回出版物ShareShare onFacebookTwitterLinked InRedditEmail查看articleFiguresReferencesRelatedDetails第五卷第2期2023年6月信息版权所有2023,Mary Ann Liebert, Inc.，出版商引用本文:Ann M. Rajnicek。Bioelectricity Buzz.Bioelectricity.Jun 2023.139-146.http://doi.org/10.1089/bioe.2023.0021Published in Volume: 5 Issue 2: June 16, 2023PDF下载
{"title":"Bioelectricity Buzz","authors":"Ann M. Rajnicek","doi":"10.1089/bioe.2023.0021","DOIUrl":"https://doi.org/10.1089/bioe.2023.0021","url":null,"abstract":"BioelectricityVol. 5, No. 2 Bioelectricity BuzzBioelectricity BuzzAnn M. RajnicekAnn M. RajnicekAnn M. Rajnicek, BS, PhD, FRSB, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, AB25 2ZD Aberdeen, United Kingdom E-mail Address: [email protected]Search for more papers by this authorPublished Online:16 Jun 2023https://doi.org/10.1089/bioe.2023.0021AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetails Volume 5Issue 2Jun 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Ann M. Rajnicek.Bioelectricity Buzz.Bioelectricity.Jun 2023.139-146.http://doi.org/10.1089/bioe.2023.0021Published in Volume: 5 Issue 2: June 16, 2023PDF download","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136169642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"We Are Electric: The New Science of Our Body's Electrome, by Sally Adee","authors":"Alistair Nunn","doi":"10.1089/bioe.2023.0016","DOIUrl":"https://doi.org/10.1089/bioe.2023.0016","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"8 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91107261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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