Bioelectricity最新文献

The utilization of extremely low-frequency magnetic fields has been widely explored across various scientific domains. According to Faraday's law, time-varying magnetic fields induce corresponding electric fields, affecting ions and dipoles. However, the symmetrical patterns of sinusoidal and square magnetic fields often limit their effectiveness. This study proposes the use of sawtooth magnetic fields (STMFs) for their ability to generate asymmetrical electric fields. STMFs create strong electric fields in one direction over a short duration and weaker fields in the opposite direction over a longer period, potentially improving effectiveness. Supporting evidence includes studies on transcranial magnetic stimulation, showing the superior impact of monophasic pulses compared with biphasic ones. Furthermore, research on pulsed and switching magnetic fields has demonstrated significant impacts on brain signals, cognitive function, drug delivery, and oncology applications. If validated, STMFs could advance therapeutic interventions and biomedical research.

Objective: To observe the effect of hawthorn red pigment (HRP) on meridian voltage in 20 volunteers over a period of 90 days.

Methods: The characteristic absorption peak of HRP was determined by ultraviolet-visible spectroscopy full-wavelength absorption analysis scanning, and its solution particle size was measured by Nano-ZS Malvern laser particle size analyzer. Volunteers were required to take a 100 mL HRP solution containing 4.0 g hawthorn powder three times a day after meals. The measurement time for meridian surface voltage was from 09:00 to 11:00 after breakfast, with the first administration at 09:30.

Results: HRP had a characteristic absorption peak at 280 nm, and the average particle size was 137.03 ± 1.44 nm. Among the five volunteers who completed the experiment, the spleen meridian had the most significant decompression effect, with the initial voltage dropping from 14.11 to -7.25 mV on the seventh day (p < 0.05). In addition, the heart meridian voltage gained the most within 90 min, reaching 18.55 mV on the 28th day (p < 0.05), while the pericardium meridian had the greatest loss, with the maximum being 9.24 mV on the 28th day (p < 0.05) and 9.36 mV on the 90th day (p < 0.05).

Conclusion: HRP has the effects of activating the heart meridian, boosting the mind, and relieving the pressure of the pericardium meridian. Regular consumption can reduce the stress on the liver, spleen, and kidney meridians, especially with a significant improvement in the spleen meridian within 28 days. This finding is consistent with the traditional efficacy of hawthorn in strengthening the spleen.

The electrical and magnetic sensory systems of marine animals provide remarkable insights into evolutionary adaptation and their technological potential. This study explores the bioelectric abilities of marine species such as stingrays, electric eels, dolphins, and hammerhead sharks, which utilize specialized organs for hunting, navigation, and self-defense. These adaptations have inspired biomimetic innovations, including underwater navigation devices, bioelectric sensors, and medical diagnostic tools. This study uses a descriptive and qualitative method to show how electroreceptors like the ampullae of Lorenzini help the body pick up on small electric and magnetic fields. These capabilities have significant implications for the development of efficient energy systems, advanced navigation tools, and sensitive medical technologies. However, ethical and ecological challenges arise, especially concerning the conservation of marine species and their habitats. This study highlights the necessity of sustainably integrating biomimetic technologies and promoting further interdisciplinary research to enhance applications while safeguarding marine ecosystems.

Sensation begins at the periphery, where distinct transducer proteins, activated by specific physical stimuli, initiate biological events to convert the stimulus into electrical activity. These evoked pulse trains encode various properties of the stimulus and travel to higher centers, enabling perception of the physical environment. Transduction is an essential process in all of the five senses described by Aristotle. A substantial amount of information is already available on how G-protein coupled receptor proteins transduce exposure to light, odors, and tastants. Functional studies have revealed the presence of mechanosensitive (MS) ion channels, which act as force transducers, in a wide range of organisms from archaea to mammals. However, the molecular basis of mechanosensitivity is incompletely understood. Recently, the structure of a few MS channels and the molecular mechanisms linking mechanical force to channel gating have been partially revealed. This article reviews recent developments focusing on the molecular basis of mechanosensitivity and emerging methods to investigate MS channels.

The emerging field of bioelectronic therapeutics unfolds great opportunities for treating numerous neurological and inflammatory conditions by utilizing the amalgamation of molecular medicine, neuroscience, engineering, and computing. These innovative treatments leverage advanced technology to precisely identify, design, and regulate electrical signaling patterns in the nervous system, addressing multiple diseases. Modifying neural signaling patterns to produce therapeutic effects at a particular organ may blur the lines between conventional medical practices. These modify the neurological behavior using electrical, magnetic, optical, and ultrasonic pulses through closed-loop systems to optimize neural behavior. The Food and Drug Administration (FDA) has approved numerous invasive and noninvasive bioelectronic devices, in the treatment of various neuronal diseases and non-neuronal diseases. Furthermore, the FDA has approved many devices for clinical studies. The field of bioelectronics encounters challenges in integrating with the health care system, including incomplete understanding of human nervous anatomy, neuronal function, membrane potential, and technological limitations. This review aims to explore bioelectronics therapeutics, their role or action in challenges to growth and their solutions, and the prospects of bioelectronic therapeutics.

Introduction: With the increased use of metallic devices in medical disciplines, the number of potential complications has also risen. Orthopedic implant-related infections are a serious complication often requiring a combination of surgical and prolonged antibiotic treatment. Biofilms play an important role in implant-related infections, and many different strategies have been studied to remove it. The purpose of our study was to evaluate the effectiveness of electrical fields and pulse lavage to remove S. epidermidis biofilm from metallic surfaces used in joint arthroplasty.

Methods: We compared five different models and combination treatments in an in vitro scenario to remove the biofilm. Five different models were compared with a model without treatment (control): (a) low-pressure pulse lavage, (b) high-pressure pulse lavage, (c) pulsed electrical fields, (d) low-pressure pulse lavage in combination with pulsed electrical fields, and (e) high-pressure pulse lavage in combination with pulsed electrical fields. Electrical fields were applied using 25 pulses at 15 V. Each pulse lasted 0.1 s and was applied every 0.5 s for a total exposure time of 12.5 s. The exposure time for irrigation was set at 25 s.

Results: The most effective model for removing biofilm from cobalt-chrome surfaces was a combination of high-pressure pulse lavage and electrical fields.

Conclusion: Our study results suggest the use of pulsed electrical fields is effective at removing biofilm and that our tested conditions could be translated to a clinical scenario involving infected medical devices.

The story of my journey from marine biology to cancer detection by voltage imaging.