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Influence of the use of atypical antipsychotics in metabolic syndrome. 非典型抗精神病药物对代谢综合征的影响。
Q3 Medicine Pub Date : 2020-05-01 Epub Date: 2020-07-20 DOI: 10.18176/resp.00014
P Doménech-Matamoros

Objectives: To describe the possible relationship between the use of antipsychotic drugs and the presence of metabolic syndrome. Other objectives are to list the main side effects of antipsychotic treatment, and to determine if there is any pharmacological treatment that can contribute towards counteracting metabolic syndrome.

Material and method: A narrative bibliographic review was carried out of the following databases: PubMed, Cochrane, CINAHL, IBECS, LILACS and HealthCare. Preference in the selection process was given to clinical trials and systematic review articles or review articles and some articles that were considered relevant because of their content. The time period was limited to between January 2014 and November 2019. The languages were English and Spanish. Repeated articles and those that were not related to the objectives were rejected. The search criteria were: "antipsychotic AND metabolic syndrome"; "schizophrenia AND metabolic syndrome"; "bipolar disorder AND metabolic syndrome"; "metabolic syndrome AND suicide NOT disorder"; "metabolic syndrome AND prisons"; "metabolic syndrome AND prolactin".

Results: 24 articles were selected out of the 510 that were consulted. The relationship between atypical antipsychotics and metabolic syndrome was evident. Other anticholinergic, antidopaminergic effects, extrapyramidal syndromes, neuroleptic malignant syndrome, hypotension, arrhythmias, sedation, hypovitaminosis D, increased prolactin, sexual dysfunction, sleep disturbances, etc. are also highlighted. Pharmacological associations with other drugs were also found.

Discussion: There is a relationship between the use of atypical antipsychotics and weight gain, lipid disorders, glucose and high blood pressure. There are some associated drugs that decrease some symptoms (ranitidine, topiramate, metformin, melatonin, modafinil). Patients taking this type of medication should be monitored and encouraged to lead healthy lifestyles.

目的:描述抗精神病药物的使用与代谢综合征之间的可能关系。其他目的是列出抗精神病药物治疗的主要副作用,并确定是否有任何药物治疗可以有助于对抗代谢综合征。材料和方法:对以下数据库进行叙述性文献综述:PubMed、Cochrane、CINAHL、IBECS、LILACS和HealthCare。在选择过程中,优先考虑临床试验和系统综述文章或综述文章以及一些因其内容而被认为相关的文章。该时间段限于2014年1月至2019年11月。语言是英语和西班牙语。重复的文章和与目标无关的文章被拒绝。搜索标准为:“抗精神病药和代谢综合征”;“精神分裂症与代谢综合征”;“双相情感障碍和代谢综合征”;“代谢综合征和自杀失调症”;“代谢综合征与监狱”;"代谢综合征和催乳素"结果:从510篇文献中筛选出24篇。非典型抗精神病药物与代谢综合征的关系明显。其他抗胆碱能、抗多巴胺能作用、锥体外系综合征、抗精神病药恶性综合征、低血压、心律失常、镇静、维生素D缺乏症、催乳素增加、性功能障碍、睡眠障碍等也被强调。与其他药物的药理关联也被发现。讨论:非典型抗精神病药物的使用与体重增加、血脂紊乱、血糖和高血压之间存在关系。有一些相关药物可以减轻某些症状(雷尼替丁、托吡酯、二甲双胍、褪黑素、莫达非尼)。服用这类药物的患者应该受到监控,并鼓励他们过健康的生活方式。
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引用次数: 7
Metabolic comorbidity, the new enemy. Metabolic syndrome and steatohepatitis. 代谢共病,新的敌人。代谢综合征和脂肪性肝炎。
Q3 Medicine Pub Date : 2020-05-01 DOI: 10.18176/resp.00010
J M Rivera Esteban, S Augustin Recio
55 doi: 10.18176/resp.00010 In recent decades we have observed a progressive increase in the prevalence of non-communicable chronic diseases worldwide. This trend is more notable in developed countries and has been attributed to (amongst other factors) a gradual ageing of the population, unhealthy lifestyles and to healthcare advances that have increased life expectancy. The prison population is also afectted by these global socio-demographic changes. The prison population in Spain has been ageing progressively in recent years, mainly due to an increased imprisonment of older people and longer sentences. At present, the average age of inmates in Spain is 39 years and almost 30% of inmates are over 45 years of age1,2. One non-communicable chronic disease that has recently come under the spotlight is metabolic syndrome. The incidence of this condition has increased exponentially in recent years to become one of the main public health concerns of this century and is now a high priority health objective at international level. Metabolic syndrome is made up of a spectrum of diseases (obesity, higharterial hypertension, diabetes mellitus and dyslipidemia), and their importance rests on their role as risk factors for high morbimortality diseases, such as cardiovascular, respiratory and hepatic diseases, etc3,4. National studies in general population shows a prevalence of metabolic syndrome in Spain around 22-32%, but unfortunately there are very few studies evaluating the presence and impact of metabolic syndrome in prison population. The prevalence of arterial hypertensión in Spanish prisons is estimated to be 25%; while levels of dyslipidemia are estimated at 18% and diabetes mellitus at 10% in persons over 45 years of age, while 20% of such patients are obese (defined as a body mass index of over 30 kg/m2)5,6 Such numbers contradict the stereotypical perceptions held in experts circles outside prison, since they are not very different from those observed amongst the general population. One factor that could help to explain the increase of metabolic pathology amongst inmates is that the prison population is ageing, as we commented above. Another probable explanation is that particular factors of this population are contributing towards the increase in prevalence. On the one hand, we know that the prevalence of metabolic syndrome increases by up to 70% in patients with mental illnesses in the general population. These patients often take second-generation antipsychotic drugs, which are linked to weight gain and the risk of dyslipidemia or diabetes mellitus. This factor takes on even greater importance in prison, where the prevalence of severe mental illness is four times that of the general population, and almost half of the patients that go to psychiatric consultations in prison receive treatment with neuroleptic medication7. It has also been documented that the prison population is more likely to fall ill than the general public, when compared by age
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引用次数: 0
Prevalence of overweight and obesity in a Mexican prison. 墨西哥监狱中超重和肥胖的流行程度。
Q3 Medicine Pub Date : 2020-05-01 Epub Date: 2020-07-20 DOI: 10.18176/resp.00011
A J Argüello-González, M A García-Zazueta

Objectives: Overweight and obesity constitute a public health problem; There are few prevalence studies of inmates. The objectives of this study are to determine the prevalence of overweight and obesity amongst inmates of the Islas Marias Prison Complex and to evaluate the waist-to-hip ratio (WHR) and the waist-to-height ratio (WHtR) as diagnostic measurements for abdominal obesity in this population.

Material and method: Analytical, retrospective cross-sectional study at Rural Hospital No. 20 Islas Marias Nayarit, Mexico, with 426 cases from January 2016 to March 2017, who were male inmates from 18 to 73 years of age. The following ratios were calculated: BMI, WHR WHtR. A descriptive analysis was carried out for quantitative variables, frequencies and percentages by group, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Youden index, positive and negative likelihood ratios of WHR and WHtR; ANOVA F test, Student's t-test, ROC curve, STROBE statement, SPSS v. 22.

Results: 51.41% cases presented as overweight, 25.35% were obese, the cut-off point was 0.935 for WHR (s = 0.833; e = 0.717) and 0.545 for WHtR ICA (s = 0.981; e = 0.818). WHtR showed a good performance according to the Youden index.

Discussion: There was a high prevalence of overweight and obesity in prisoners at the Islas Marias Prison Complex, WHtR showed better performance than WHR for diagnosing abdominal obesity. It is suggested that measurement of WHI should be included in daily medical practice.

目标:超重和肥胖构成一个公共卫生问题;很少有关于囚犯的患病率研究。本研究的目的是确定Islas Marias监狱综合体囚犯中超重和肥胖的患病率,并评估腰臀比(WHR)和腰高比(WHtR)作为该人群腹部肥胖的诊断测量。材料与方法:对2016年1月至2017年3月墨西哥第20 Islas Marias Nayarit农村医院426例病例进行分析性、回顾性横断面研究,患者为18至73岁的男性囚犯。计算BMI、WHR、WHtR。对定量变量、分组频率和百分比、敏感性、特异性、阳性预测值(PPV)、阴性预测值(NPV)、约登指数、WHR和WHtR的阳性和阴性似然比进行描述性分析;方差分析F检验,学生t检验,ROC曲线,STROBE语句,SPSS v. 22。结果:51.41%的患者表现为超重,25.35%的患者表现为肥胖,WHR的分界点为0.935 (s = 0.833;e = 0.717), WHtR ICA为0.545 (s = 0.981;E = 0.818)。根据约登指数,WHtR表现良好。讨论:Islas Marias监狱囚犯中超重和肥胖的患病率较高,WHtR在诊断腹部肥胖方面的表现优于WHR。建议将WHI的测量纳入日常医疗实践。
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引用次数: 3
Perceived social support, resilience and consumption of psychoactive substances amongst inmates in prisons. 监狱囚犯的感知社会支持、复原力和精神活性物质消费。
Q3 Medicine Pub Date : 2020-05-01 Epub Date: 2020-07-20 DOI: 10.18176/resp.00013
F Caravaca-Sánchez, M García-Jarillo

Objectives: To determine the influence of perceived social support and resilience in the use of alcohol and other drugs amongst female inmates.

Material and method: A cross-sectional study with 174 inmates was conducted in two prisons in the Region of Murcia. A self-administered questionnaire was used, which included socio-demographic, prison, alcohol and other drug consumption, perceived social support and resilience variables.

Results: 28.2% of the inmates consumed at least one of the substances analyzed (alcohol, cannabis, cocaine, heroin and/or tranquillizers without medical prescription) in prison. The female consumers showed significantly lower levels of perceived social support and resilience, compared to the counterparts who did not consume in prison.

Discussion: Findings show how perceived social support and resilience are factors of protection against substance use in prison, and these can be incorporated in future prevention programs for the consumption of alcohol and other drugs during imprisonment.

目的:确定感知到的社会支持和适应能力对女性囚犯使用酒精和其他药物的影响。材料与方法:对穆尔西亚地区两所监狱的174名囚犯进行了横断面研究。使用了一份自我填写的问卷,其中包括社会人口统计、监狱、酒精和其他药物消费、感知到的社会支持和复原力等变量。结果:28.2%的囚犯在监狱中至少使用一种所分析的物质(酒精、大麻、可卡因、海洛因和/或无医生处方的镇静剂)。与没有在监狱消费的人相比,女性消费者表现出明显较低的感知社会支持和弹性水平。讨论:调查结果表明,感知到的社会支持和复原力如何成为防止在监狱中使用药物的因素,这些因素可以纳入未来监禁期间酒精和其他药物消费的预防方案。
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引用次数: 6
Mental illness and social exclusion: assessment of the risk of violence after release. 精神疾病和社会排斥:释放后暴力风险评估。
Q3 Medicine Pub Date : 2020-01-01 Epub Date: 2020-04-27 DOI: 10.18176/resp.0004
R Fernández-García-Andrade, B Serván-Rendón-Luna, V Vidal-Martínez, E Medina-Téllez de Meneses, B Reneses-Prieto

Objectives: To examine the predictive validity of the HCR-20 (The Historical Clinical Risk Management-20) to predict future violent incidents in a representative sample of patients with severe mental disorders and with a history of previous admission to prison, who after release are in a situation of extreme social exclusion.

Material and method: The study sample was selected from the 235 patients treated by the Mental Health Street Team of Madrid (ECASAM) from June 2014 to June 2017, including those with a previous history of a previous internment in a penitentiary (about which, the HCR-20 was completed).

Results: Of the 44 patients included, 29.6% (n=13) ended up participating in a violent incident after the release. The ROC curves (Receiver Operating Characteristic) analysis indicated that the total score of HCR-20 (AUC 0.98, p=0.01) has a high predictive validity.

Conclusions: The social and medical changes that take place after the release of patients with severe mental illness justify the need to reassess the risk of violence. In this evaluation, the HCR-20 guide is a useful tool for predicting the risk of involvement in future violent incidents, and the inclusion of factors such as social exclusion and its consequences, as well as problems with substance use is especially important.

目的:检验HCR-20(历史临床风险管理-20)预测严重精神障碍患者未来暴力事件的预测有效性,这些患者有前科,释放后处于极端社会排斥状态。材料和方法:研究样本选自2014年6月至2017年6月马德里精神卫生街道小组(ECASAM)治疗的235名患者,包括先前有监狱拘留史的患者(HCR-20已完成)。结果:在纳入的44例患者中,29.6% (n=13)在出院后最终参与了暴力事件。ROC曲线(受试者工作特征)分析显示,HCR-20总分(AUC 0.98, p=0.01)具有较高的预测效度。结论:严重精神疾病患者释放后发生的社会和医疗变化证明有必要重新评估暴力风险。在这一评估中,HCR-20指南是预测未来参与暴力事件风险的有用工具,将社会排斥及其后果以及药物使用问题等因素纳入其中尤为重要。
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引用次数: 3
Involuntary outpatient treatment: the ethical implications. 非自愿门诊治疗:伦理意义。
Q3 Medicine Pub Date : 2020-01-01 DOI: 10.18176/resp.0001
M Castellano Arroyo
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引用次数: 0
Psychiatrists' opinion about involuntary outpatient reatment. 精神科医生对非自愿门诊治疗的看法。
Q3 Medicine Pub Date : 2020-01-01 Epub Date: 2020-04-27 DOI: 10.18176/resp.0006
A Moleón Ruiz, J C Fuertes Rocañín

Introduction: Involuntary outpatient treatment (IOT) is a kind of compulsory outpatient treatment, whose aim is to improve the adherence to the treatment in people with severe mental illness and with no awareness of disease. In these cases, therapeutic abandonment involves a high risk of relapse, with appearance of disruptive and/or self-aggressive or hetero-aggressive behavior, repeated hospitalizations and frequent emergencies. The application of IOT is not an issue without contention. Therefore, the need of legislative regulation in Spain has been a controversial subject for several years, and there are both advocates and opponents.

Objective: The objective of this study is to bring together the opinion of clinical psychiatrists and resident doctors in psychiatry on the involuntary outpatient treatment and its legislative regulation.

Material and method: This study is descriptive in nature. The study population consists of 42 clinical professionals in mental health (32 psychiatrists and 10 resident doctors in psychiatry). At the beginning of this study (March 2018), some of these professionals were working in the Psychiatry Department's facilities of the University Hospital Complex of Huelva. A personal survey in paper form consisting of ten questions about IOT was carried out to each member of this study.

Results: 85.7% of clinicians know the current initiative that tries to carry out the legislative regulation of IOT, and 92.8% of them agree to such regulation. In this sense, 83.3% of them are against the fact that more coercive measures for the psychiatric patients such as the involuntary commitment or the civil incapacitation are regulated and IOT is not. On the one hand, 78.6% of the professionals in mental health believe that IOT is beneficial for the patients. Moreover, 95.2% of them think that is beneficial for their relatives, too. On the other hand, 78.6% of clinicians do not consider that the application of IOT to mentallyill patients is stigmatizing.

Conclusion: The vast majority of clinicians think that the legislative regulation of involuntary outpatient treatment is necessary in Spain, and they think this treatment is beneficial not only for the patient but also for their family.

非自愿门诊治疗是一种强制性门诊治疗,其目的是提高无疾病意识的严重精神疾病患者对治疗的依从性。在这些病例中,放弃治疗包括复发的高风险,出现破坏性和/或自我攻击或异性攻击行为,反复住院和频繁的紧急情况。物联网的应用并不是一个没有争议的问题。因此,几年来,西班牙是否需要立法监管一直是一个有争议的话题,支持者和反对者都有。目的:探讨临床精神科医师与精神科住院医师对非自愿门诊治疗的看法及立法规制。材料与方法:本研究为描述性研究。研究人群包括42名精神卫生临床专业人员(32名精神科医生和10名精神病学住院医生)。在本研究开始时(2018年3月),其中一些专业人员在韦尔瓦大学医院综合医院的精神病学部门工作。本研究的每个成员都进行了一份由10个关于物联网的问题组成的纸上个人调查。结果:85.7%的临床医生了解目前尝试对物联网进行立法监管的倡议,92.8%的临床医生同意对物联网进行立法监管。从这个意义上说,83.3%的人反对规范非自愿收容或民事丧失行为能力等针对精神病人的更多强制措施,而不规范IOT。一方面,78.6%的心理健康专业人士认为物联网对患者有益。此外,95.2%的人认为这对他们的亲戚也有好处。另一方面,78.6%的临床医生不认为将物联网应用于精神疾病患者是一种耻辱。结论:绝大多数临床医生认为西班牙立法规范非自愿门诊治疗是必要的,他们认为这种治疗不仅对患者有利,而且对其家庭也有利。
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引用次数: 1
Diagnosed diabetes and optimal disease control of prisoners in Catalonia. 加泰罗尼亚囚犯糖尿病诊断与最佳疾病控制。
Q3 Medicine Pub Date : 2020-01-01 Epub Date: 2020-04-27 DOI: 10.18176/resp.0003
M Pagarolas-Soler, P Alonso-Gaitón, N Sapera-Miquel, J Valiente-Soler, M Sánchez-Roig, A Coll-Cámara

Objectives: To determine the prevalence of diagnosed diabetes (DD) and its control amongst prisoners in Catalonia.

Materials and methods: Transversal study carried out in four Catalan prisons between April and May 2016. The prevalence of DD in inmates was calculated by intentional sampling and collecting the following variables about: a) type of diabetes, value of glycosylated hemoglobin (HbA1c) and treatment; b) comorbidities; c) epidemiological and prison variables; knowledge of hyperglycaemia/hypoglycaemia, and e) participation in educational activities. Optimal control was considered to exist if Hb1A<7.5% and high risk if Hb1Ac >9%. Test x2 was used in order to study the association among qualitative variables. Multivariate analysis was carried out using logistic regression to determine variables associated with disease control.

Results: The study group considered 4,307 male patients, 50.2 years of average age. Ninety-three cases of DD were detected (prevalence 2.16%). 22.6% were treated with insulin, 51.6% with oral antidiabetics (OAD) and 25.8% with both. Type 1 users were younger, thinner, diagnosed at a younger age, heavy drug users and acknowledged to know how to act in the event of hyperglycaemia/hypoglycaemia. Optimal control was more common in type 2 diabetics, but multivariate analysis only associated it with OAD treatment.

Discussion: The prevalence observed in DD is much lower than that of the population outside prison and may be underestimated. Optimal control is low, and risk is very high, the results may be biased by the type of population, frequently drug-dependent and with few healthy habits. It is recommended to implement diabetes programmes or improve existing ones in order to increase the diagnosis and management of the disease.

目的:确定诊断糖尿病(DD)的患病率及其在加泰罗尼亚囚犯中的控制。材料与方法:2016年4月至5月在加泰罗尼亚四所监狱进行了横向研究。通过有意抽样和收集以下变量来计算囚犯的DD患病率:a)糖尿病类型、糖化血红蛋白(HbA1c)值和治疗;b)并发症;C)流行病学和监狱变量;高血糖/低血糖知识,e)参与教育活动。当Hb1A9%时,认为存在最优控制。采用检验x2研究各定性变量间的相关性。采用logistic回归进行多变量分析,确定与疾病控制相关的变量。结果:研究组纳入男性患者4307例,平均年龄50.2岁。检出DD 93例(患病率2.16%)。22.6%的患者接受胰岛素治疗,51.6%的患者接受口服抗糖尿病药(OAD)治疗,25.8%的患者同时接受胰岛素和口服抗糖尿病药治疗。1型使用者更年轻,更瘦,在年轻时被诊断为重度吸毒者,并且被认为知道如何应对高血糖/低血糖。最优控制在2型糖尿病患者中更为常见,但多变量分析仅将其与OAD治疗相关联。讨论:观察到的DD患病率远低于监狱外的人群,可能被低估了。最优控制低,风险非常高,结果可能因人群类型而有偏差,通常是药物依赖和很少有健康习惯。建议实施糖尿病规划或改进现有规划,以增加对该疾病的诊断和管理。
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引用次数: 2
Evaluation of the impact of family relations on prisoners' health in Spain. 评价西班牙家庭关系对囚犯健康的影响。
Q3 Medicine Pub Date : 2020-01-01 Epub Date: 2020-04-27 DOI: 10.18176/resp.0005
F Caravaca-Sánchez, E Pastor-Seller

Objectives: Literature on this issue has shown a high prevalence of alcohol and other drug use in the prison population. Although many risk factors have been linked to this behavior in prison, it is not common to find research that analyses the influence of family/social contact in prison.

Material and method: A cross-sectional study was carried out on 2,709 inmates (2,484 men and 225 women) in 9 prisons in Spain, data was collected through self-report questionnaires, including information at socio-demographic level, family-social contact and use of alcohol and other drugs in the last month in prison.

Results: Inmates with no family contact in prison show a higher prevalence of use for all the substances analyzed, binary logistic regression analysis shows statistically significant associations with the use of cannabis (OR: 1.86, p ≤0.001) or cocaine (OR: 3.40, p ≤0.001) in prison.

Discussion: More knowledge about this public health problem amongst social workers in the prison environment could be an effective diagnostic and preventive tool for reducing the use of alcohol and other drugs during imprisonment.

目标:关于这一问题的文献表明,监狱人口中酗酒和使用其他药物的情况非常普遍。虽然许多风险因素与监狱中的这种行为有关,但分析监狱中家庭/社会接触影响的研究并不常见。材料和方法:对西班牙9所监狱的2 709名囚犯(2 484名男性和225名女性)进行了一项横断面研究,通过自我报告问卷收集数据,包括社会人口层面的信息、家庭社会接触和监狱最后一个月的酒精和其他药物使用情况。结果:在监狱中没有家庭接触的囚犯使用所有分析物质的比例更高,二元logistic回归分析显示,与监狱中大麻(OR: 1.86, p≤0.001)或可卡因(OR: 3.40, p≤0.001)的使用具有统计学意义。讨论:监狱环境中的社会工作者对这一公共卫生问题有更多的了解,可以成为减少监禁期间酒精和其他药物使用的有效诊断和预防工具。
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引用次数: 0
Diseases and access to treatment by the Peruvian prison population: an analysis according to gender. 秘鲁监狱人口的疾病和治疗机会:按性别分列的分析。
Q3 Medicine Pub Date : 2020-01-01 Epub Date: 2020-04-27 DOI: 10.18176/resp.0002
A Hernández-Vásquez, C Rojas-Roque

Objective: In Peru, prisons are spaces with overcrowding, deteriorated infrastructure, poor sanitary conditions and difficult access to medical treatment. The objective of this study is to estimate the burden of disease and access to treatment for different morbidities in the Peruvian inmate population.

Methods: An analysis of secondary data of the First National Penitentiary Census (PCNP) 2016 in Peru was carried out. The absolute frequencies and percentages of each self-reported health condition, the presence of a diagnosis of a disease before entering the prison system and access to treatment were obtained.

Results: 74,130 inmates were included in the analysis. The most common diseases in prisons are depression (9.6%), anxiety (8.6%), chronic lung disease (8.4%) and arterial hypertension (6.9%). All diseases included, with the exception of hepatitis, have a diagnostic before the incarceration of less than 60%. Access to medical treatment was higher in women than in men and in general, mental health illnesses had low access to medical treatment.

Conclusions: Chronic and infectious diseases are frequent in those deprived of liberty, with mental health problems being more prevalent in women. In general, access to treatment is low, especially in men and for mental health illnesses. This situation reflects the need to develop intervention programs that promote health and increase the universality of health care in those deprived of liberty.

目标:在秘鲁,监狱人满为患,基础设施恶化,卫生条件差,难以获得医疗。这项研究的目的是估计秘鲁囚犯人口中不同疾病的疾病负担和获得治疗的机会。方法:对秘鲁2016年第一次全国监狱人口普查(PCNP)的二次数据进行分析。获得了每一种自我报告的健康状况的绝对频率和百分比、进入监狱系统之前是否诊断出某种疾病以及获得治疗的情况。结果:74130名在押人员被纳入分析。监狱中最常见的疾病是抑郁症(9.6%)、焦虑症(8.6%)、慢性肺病(8.4%)和动脉高血压(6.9%)。除肝炎外,所有疾病在监禁前得到诊断的比例不到60%。妇女获得医疗的机会高于男子,总的来说,精神疾病获得医疗的机会很少。结论:慢性和传染性疾病在被剥夺自由者中很常见,精神健康问题在妇女中更为普遍。总的来说,获得治疗的机会很低,特别是在男子和精神疾病方面。这种情况反映出有必要制定干预方案,促进被剥夺自由者的健康和增加保健的普遍性。
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引用次数: 7
期刊
Revista Espanola de Sanidad Penitenciaria
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