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Aesthetic-functional rehabilitation of deciduous anterior teeth without removal of carious tissue: series of clinical cases 不拔除龋齿的乳前牙美学功能康复:一系列临床病例
Pub Date : 2022-01-01 DOI: 10.1590/1981-863720200005920200206
Alessandra Rech, Mariana Olberttz, Daniel Junior Moreira Paiva, Adelizi Nataly Ribeiro, T. Gimenez, J. Imparato
ABSTRACT The treatment of cavity carious lesions in anterior deciduous teeth is a frequent demand in the pediatric dentistry clinic, since the control of the disease in early childhood still presents itself as an inter-factor challenge in child health care. While the scientific evidence on the minimally invasive principles of approach in Dentistry is presented at an increasing level, the alternatives for restorative treatment in anterior deciduous teeth still face the low availability of reports that associate minimal intervention with the aesthetic needs inherent to the treatment. Thus, this article presents a series of cases in which direct restorations in composite resin, without removing carious tissue using polyvinyl matrices, were treatment alternatives for moderate and severe caries lesions in anterior deciduous teeth. It was observed, therefore, that the use of this artifact helped the rehabilitation of compromised dental elements with speed and satisfactory 50 result, suggesting that this is an appropriate approach for application in Pediatric Dentistry, 51 since it offers resistance, durability, besides providing aesthetics and functionality, it presents lower cost and agility as it eliminates the laboratory phase.
前乳牙龋齿的治疗是儿童牙科临床的一个常见需求,因为幼儿期疾病的控制仍然是儿童卫生保健中的一个跨因素挑战。虽然关于微创方法的科学证据越来越多,但前乳牙修复治疗的替代方案仍然面临着将最小干预与治疗固有的美学需求联系起来的低可用性报道。因此,本文介绍了一系列病例,其中复合树脂直接修复,不去除龋组织,使用聚乙烯基质,是治疗前乳牙中重度龋病的替代方法。因此,我们观察到,使用这种人工制品有助于修复受损的牙齿部件,速度快,效果好,这表明这是一种适用于儿科牙科的方法,51因为它提供了抵抗性,耐用性,除了提供美观和功能外,它还具有较低的成本和灵活性,因为它消除了实验室阶段。
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引用次数: 1
Evaluation of resin composite staining by beverages with acid pH 酸性pH饮料对树脂复合染色的评价
Pub Date : 2022-01-01 DOI: 10.1590/1981-86372022004320210091
R. Vieira, Isabella Henriques De Paula Vieira, Letícia Cabido Prata, Wellington Dorigheto Andrade Vieira, Diogo de Azevedo Miranda
ABSTRACT Introduction: Composite resins are an extensively used esthetic material that has excellent adaptation, reproduces the characteristics of the tooth structure and is suitable for the conditions of the oral environment. However, this material is also very susceptible to staining due to pigmentation coming from the diet and habits of the patient. Objectives: To evaluate the staining of two brands of composite resin, one nanoparticle and a nanohybrid type (Filtek Z350XT® and IPS Empress Direct®), in direct contact with the acid pH of beverages. Methods: In total 40 specimens were made, 20 of each type of resin studied. After being inserted into a Teflon matrix and light activated, the samples were removed, stored in containers with 2 ml of artificial saliva and kept in the refrigerator. Every day 20 of these samples were placed in direct contact with 2 ml Gatorade, and the other 20 samples, in 2 ml of wine, each set for 30 minutes. After 30 minutes, the acid pH substances were removed, and 2 ml of artificial saliva was again placed in the container. This process was repeated every day for 10 days. Results: The results showed that the nanoparticle resin (Filtek Z350XT) was more susceptible to staining than the nanohybrid type (Empress Direct®) when in contact with the wine. When wine and Gatorade were compared, the solution with higher staining capacity was shown to be wine. Conclusion: The two resins tested were susceptible to staining in a 10-day period. Mottling and more staining was visibly detected after samples were immersed in the solution with the higher pH, and nanoparticulate resin was more susceptible to staining.
摘要简介:复合树脂是一种应用广泛的美容材料,具有良好的适应性,能再现牙齿结构的特性,适应口腔环境的条件。然而,由于患者的饮食和习惯造成的色素沉着,这种材料也很容易被染色。目的:评价两种品牌的复合树脂,一种纳米颗粒型和一种纳米混合型(Filtek Z350XT®和IPS Empress Direct®)与饮料酸性pH值直接接触时的染色效果。方法:共制作标本40个,每种树脂各20个。将样品插入聚四氟乙烯基质并进行光活化后,取出样品,放入装有2毫升人工唾液的容器中保存,并保存在冰箱中。每天,其中20个样本与2毫升的佳得乐直接接触,另外20个样本与2毫升的葡萄酒直接接触,每组30分钟。30分钟后,去除酸性pH物质,再次将2ml人工唾液放入容器中。这个过程每天重复10天。结果:纳米树脂(Filtek Z350XT)与酒接触时,比纳米混合型树脂(Empress Direct®)更容易染色。当葡萄酒和佳得乐进行比较时,染色能力较高的溶液显示为葡萄酒。结论:两种树脂在10天内均易染色。在pH值较高的溶液中浸泡后,样品明显出现斑驳和染色增多,纳米颗粒树脂更容易染色。
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引用次数: 0
Restorative treatment in patient with Williams Syndrome: case report 威廉姆斯综合征恢复性治疗1例
Pub Date : 2022-01-01 DOI: 10.1590/1981-86372022002620200155
Alessandra Rech, Isadora Rinaldi, T. Marega
ABSTRACT In Dentistry, any user with one or more limitations, of temporary or permanent mental nature, of physical, sensory, emotional or medical growth, is considered to be a Patient with Special Needs, preventing him from being subjected to a conventional dental situation. These patients form a group which may be considered at high risk for the development of oral diseases, according to the kind of pathogen. Among them, is the Williams-Beuren Syndrome, a rare congenital disease with cardiovascular involvement, mental retardation, dysmorphic face, idiopathic hypercalcemia, musculoskeletal problems, dental and growth anomalies. Familial and sporadic cases are thought to result from deletion of genetic material from adjacent genes located on the long arm of chromosome 7. This article reports a clinical case involving a four-year-old boy with Williams-Beuren Syndrome, referred to the clinic of the Specialization Course for Patients with Special Needs, at the São Leopoldo Mandic Dental Research Center, Campinas (SP). As the patient was resistant to dental care, in order to reduce anxiety and increase collaboration in clinical sessions, the Hixizine® medication was administered. For atraumatic restorative treatment and restorations, the following materials were used: Cleanjoy®, Futurabond DC®, Ionofil Plus® Grandioso®, Grandio® and Profluorid®. As result, it was possible to reach a level of excellence using the indicated materials and specific protocols. Based on this work and the lived experience, it can be observed that these patients can receive welcoming dental care in specialized clinics.
在牙科医学中,任何有一种或多种生理、感官、情感或医学发育方面的暂时或永久的精神缺陷的使用者,都被认为是有特殊需要的患者,使他不能接受常规的牙科治疗。根据病原体的种类,这些患者构成了一个可能被认为是口腔疾病发展的高风险群体。其中包括Williams-Beuren综合征,这是一种罕见的先天性疾病,伴有心血管疾病、智力低下、面部畸形、特发性高钙血症、肌肉骨骼问题、牙齿和生长异常。家族性和散发性病例被认为是由于位于7号染色体长臂上的邻近基因的遗传物质缺失所致。本文报告了一例临床病例,涉及一名患有Williams-Beuren综合征的四岁男孩,他被转介到坎皮纳斯(SP)的s Leopoldo Mandic牙科研究中心的特殊需要患者专业课程诊所。由于患者对牙科护理有抵抗力,为了减少焦虑并增加临床会议的合作,给予Hixizine®药物治疗。对于非创伤性修复治疗和修复,使用以下材料:Cleanjoy®,Futurabond DC®,Ionofil Plus®Grandioso®,Grandio®和Profluorid®。因此,使用指定的材料和特定的方案可以达到卓越的水平。根据这项工作和生活经验,可以观察到这些患者可以在专业诊所接受欢迎的牙科护理。
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引用次数: 0
Ex vivo evaluation of the effectiveness of XP-endo Finisher on the removal of smear layer from the root canal 体外评价XP-endo Finisher清除根管涂片层的有效性
Pub Date : 2022-01-01 DOI: 10.1590/1981-863720200005720210021
Sângela Maria da Silva Pereira, C. Carvalho, Rudys Rodolfo Tavarez, P. Nelson-Filho, L. A. D. Da Silva, E. M. Maia Filho
ABSTRACT Objective: The aim of this study was to evaluate the effectiveness of XP-endo Finisher (XP) on removal of the smear layer in root canals by comparing different irrigation protocols. Methods: Seventy-two human single-rooted teeth were similarly instrumented using R25 Reciproc files (VDW, Munich, Germany) applied in reciprocating mode with a VDW GOLD endo motor (VDW, Munich, Germany). The working length was determined at 1 mm short of the apical foramen. The canals were irrigated with 5 mL of 2.5% sodium hypochlorite during instrumentation. The teeth were divided at random into six groups (n=12). A control group, which was not submitted to the final irrigation protocol, and five experimental groups with different irrigants and agitation techniques: EDTA/File, EDTA/XP, EDTA/Passive Ultrasonic Irrigation (PUI), Distilled Water (DW)/XP, and DW/PUI). Smear layer removal quality scores were assessed in the apical, middle, and cervical thirds of the root canal based on images obtained by scanning electron microscopy. Data were analyzed using the Kruskal-Wallis test, followed by two-by-two comparisons with the Dunn test (α=5%). Results: EDTA/File, EDTA/PUI, and EDTA/XP groups demonstrated significantly lower scores than the other groups (P<0.05) in all thirds evaluated. No significant difference was observed between the groups in which distilled water was used and the control group in all thirds evaluated (P> 0.05). Conclusion: The XP-endo Finisher file did not increase the efficiency of EDTA in removal of the smear layer in root canals.
摘要目的:本研究通过比较不同灌洗方案,评价XP-endo Finisher (XP)对根管内涂抹层清除的效果。方法:使用R25 Reciproc锉(VDW, Munich, Germany)和VDW GOLD endo马达(VDW, Munich, Germany)以往复方式对72颗人单根牙齿进行类似的矫治。工作长度确定在根尖孔短1mm处。在器械过程中,用5ml 2.5%次氯酸钠冲洗管道。将牙齿随机分为6组(n=12)。对照组(未提交最终冲洗方案)和5个不同冲洗和搅拌技术的实验组:EDTA/File、EDTA/XP、EDTA/被动超声冲洗(PUI)、蒸馏水(DW)/XP和DW/PUI。根据扫描电镜获得的图像,对根管的根尖、中间和颈部三分之一的涂片层去除质量评分进行评估。采用Kruskal-Wallis检验对数据进行分析,然后采用Dunn检验进行二乘二比较(α=5%)。结果:EDTA/File组、EDTA/PUI组、EDTA/XP组得分显著低于其他组(P < 0.05)。结论:XP-endo Finisher锉对EDTA清除根管内涂片层的效果无显著影响。
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引用次数: 0
Food diet and representations of dental caries published in a traditional brazilian newspaper 食品饮食和龋齿的代表发表在传统的巴西报纸
Pub Date : 2022-01-01 DOI: 10.1590/1981-86372022003820210032
C. B. Fadel, Maria Augusta Hampf, J. Leandro, Camila Zanesco, Jean Érick Langoski, D. Bordin
ABSTRACT Objective: To apprehend the representations of dental caries present in a Brazilian print media, considering different historical periods, with emphasis on the dietary factor in the issue of etiology and disease prevention. Methods: This is a descriptive documentary research study carried out from the analysis of digitalized printed editions of Jornal do Brasil, published between 1891 and 1990, available for consultation on the electronic portal of the collection of periodicals entitled Brazilian Digital Library. For the search, the terminologies ‘cárie dentária’ and ‘cárie dental’ (both meaning dental caries) were used. The platform displays editions from pre-determined time periods. The displays were considered for all journalistic genres, composing or not the main or prominent theme. The data found were analyzed qualitatively. Results: In total, 675 occurrences were registered with the term ‘cárie dentária’ and 33 with the term ‘cárie dental’. The representations of dental caries had multiple and complex variations. The object reconstruction process generated the categories: prevention, public policy and etiology. The topic of food diet significantly crossed the entire time span studied and remained frequently linked to tooth decay, sometimes related to the etiology, sometimes to the prevention of the disease. Conclusion: Jornal do Brasil reflected old knowledge in the field of dentistry, added new scientific knowledge and popularized it for the readership of the written press.
摘要目的:了解目前在巴西印刷媒体龋齿的表现,考虑到不同的历史时期,重点是在病因和疾病预防问题的饮食因素。方法:这是一项描述性文献研究,对1891年至1990年间出版的journal do Brasil的数字化印刷版进行了分析,可在期刊集“巴西数字图书馆”的电子门户网站上查阅。搜索时使用了“cárie dentária”和“cárie dental”(都是龋齿的意思)这两个术语。该平台显示预定时间段的版本。展览考虑了所有新闻类型,构成或不是主要或突出的主题。对发现的数据进行定性分析。结果:以“cárie dentária”和“cárie dental”分别登记的病例共有675例和33例。龋齿的表现形式多样,变化复杂。对象重构过程产生的分类:预防、公共政策和病因学。在研究的整个时间跨度中,食物饮食的主题明显地与蛀牙联系在一起,有时与病因有关,有时与疾病的预防有关。结论:journal do Brasil反映了牙科领域的旧知识,增加了新的科学知识,并为书面新闻界的读者普及。
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引用次数: 0
Diametral tensile strength of conventional glass ionomer cements with modified powder ratio for uses in atraumatic restorative treatment 改良粉比常规玻璃离子水门合剂在非创伤性修复中的直径抗拉强度
Pub Date : 2022-01-01 DOI: 10.1590/1981-86372022001320200107
Fernanda Souza Vieira, Roberta Pinto Pereira, S. X. S. Costa, D. Figueiredo
ABSTRACT Objective: To identify the diametral tensile strength of Brazilian brands of conventional glass ionomer cements (GIC) when modified powder ratio in their composition compared to each other, and with high viscosity glass ionomer cement for Atraumatic Restorative Treatment (ART). Methods: Experimental study with five groups (n=10 each) and specimens (2.5 mm in height and 5.0 mm in diameter), considering G1 (Maxxion R-MR), G2 (Vidrion R-VR) and G3 Vitro molar (VM-control) according to manufacturer recommending powder/liquid (1:1), G4 (MR) and G5 (VR) plus powder (2:1). The specimens were stored in an oven at 37 ± 1 ° C for 1 day. Diametral Tensile Test was performed by the Instron model 4444. Means differences were tested by Student´s T-Test (α = 5%). Results: There significant differences were in the means (standard deviation) of diametral tensile strength of MR (1:1) 4.24 (±1.47) and MR (2:1), 5.74 (±1.51) (p=0.039) and VR (1:1) 4.50 (±1.27) and VR (2:1) 6.20 (±1.89) (p=0.029). When comparing MR and VR (2:1) with MV (1:1) 4.82 (±1.17), VR 2: 1, 6.20 (±1.89) showed significant differences (p=0.0336). Conclusion: There was a significant increase in the means of diametral tensile strength of Brazilian brands conventional GICs when powder increment, approaching the performance observed by the high viscosity GIC.
【摘要】目的:研究巴西品牌常规玻璃离子水门合剂(GIC)在其组成中修改粉比时的直径抗拉强度,并与高粘度玻璃离子水门合剂进行非创伤修复治疗(ART)的比较。方法:实验研究分为5组(每组10人)和标本(高2.5 mm,直径5.0 mm), G1 (Maxxion R-MR), G2 (Vidrion R-VR)和G3体外磨牙(vm -对照),按厂家推荐的粉液比1:1,G4 (MR)和G5 (VR)加粉(2:1)。标本在37±1℃的烘箱中保存1天。直径拉伸试验采用Instron 4444模型。均值差异采用Student’st检验(α = 5%)。结果:MR(1:1) 4.24(±1.47)、MR(2:1) 5.74(±1.51)(p=0.039)、VR(1:1) 4.50(±1.27)、VR(2:1) 6.20(±1.89)(p=0.029)的直径抗拉强度均值(标准差)有显著性差异。MR、VR(2:1)与MV(1:1)(4.82(±1.17)、VR(2:1)(6.20(±1.89))比较差异有统计学意义(p=0.0336)。结论:巴西品牌常规GIC的直径抗拉强度随粉末的增加而显著增加,接近高粘度GIC的性能。
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引用次数: 0
Important blood pressure changes in clinical practice: narrative literature review 临床实践中重要的血压变化:叙述性文献综述
Pub Date : 2022-01-01 DOI: 10.1590/1981-86372022000120210054
Maria Cristina Pedrazini, Luciane Francischini Gottschall Odone, M. F. Groppo, F. Groppo
ABSTRACT The aim of this study was to emphasize the importance of monitoring vital signs, especially blood pressure, during dental care. Through a narrative review, the changes in blood pressure that may occur during outpatient procedures and the measures to be taken were discussed. The available literature was consulted in databases (PubMed, Scielo, Web of Science and Google Scholar), complemented by the analysis of the bibliographic references included and updated until April 2021. The keywords were used: “Anamnesis”, “Arterial Pressure”, “Arterial Hypertension”, “Hypertensive Crisis”, “Risk factors”, “Stroke”, “Subclavian Theft Syndrome” and “Atherosclerosis”. It was concluded that care should be applied to all patients, but mainly to those over 50, hypertensive or not, with hypercholesterolemia, diabetes, anxious and fearful. All vital signs must be monitored, including the pain score. The situations of anxiety, pain and fear are triggers for changes in blood pressure even in normotensive patients as in controlled hypertensive patients. The blood pressure measurement, in the first consultation, must be performed in both arms and repeated annually or whenever there is a change in the patient’s health status. In all other consultations, blood pressure control, as well as the assessment of all vital signs, must be performed before, during, after the procedure and before discharge. In the face of any major change, it is necessary to assess the risk/benefit ratio of the continuity of the procedure, so that risks to patients are avoided or minimized, as well as for the necessary referrals to be made.
本研究的目的是强调在牙科护理过程中监测生命体征,特别是血压的重要性。通过叙述性的回顾,血压的变化,可能发生在门诊程序和应采取的措施进行了讨论。在数据库(PubMed、Scielo、Web of Science和Google Scholar)中查阅了现有文献,并对包括和更新到2021年4月的参考书目进行了分析。关键词:“遗忘”、“动脉压”、“动脉高血压”、“高血压危重症”、“危险因素”、“中风”、“锁骨下盗窃综合征”和“动脉粥样硬化”。结论:所有患者均应予以护理,但以50岁以上、有无高血压、高胆固醇血症、糖尿病、焦虑和恐惧者为主。必须监测所有生命体征,包括疼痛评分。焦虑、疼痛和恐惧的情况是血压变化的触发因素,即使在血压正常的患者和控制高血压患者中也是如此。首次就诊时,必须在两臂进行血压测量,并每年或每当患者的健康状况发生变化时重复一次。在所有其他咨询中,必须在手术前、手术中、手术后和出院前进行血压控制以及所有生命体征的评估。面对任何重大变化,有必要评估程序连续性的风险/收益比,以避免或尽量减少患者的风险,以及进行必要的转诊。
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引用次数: 1
Epidermal cyst: a rare case report in a 5-month-old child 表皮囊肿:一例罕见的病例报告在一个5个月大的孩子
Pub Date : 2022-01-01 DOI: 10.1590/1981-86372022004420220078
E. Stringhini Junior, Débora Gerber Kegler, V. Montalli, L. Oliveira
ABSTRACT The epidermal cyst is a rare, benign lesion, usually asymptomatic and slowly enlarging, more frequently located in the submandibular region. Its etiology is believed to be associated with the epithelial residual tissues retained in the midline during the closure of the first and second brachial arches, in the third and fourth weeks of intra-uterine life. Its clinical characteristics are of a rubbery consistency to palpation, well defined borders, with the absence of skin appendages within their squamous epithelium lined walls. The final diagnosis is confirmed through histopathological examination with stratified squamous epithelium findings in the cystic fluid lumen or keratin. The treatment is usually surgical and without recurrence and the final diagnosis is confirmed through histopathological examination. This paper aims to present a case report of a congenital epidermal cyst in a 5-month-old female patient located in the mouth floor near the sublingual gland duct. The case was treated with excisional biopsy and after follow-up, there was no recurrence.
表皮囊肿是一种罕见的良性病变,通常无症状,缓慢扩大,多见于下颌下区域。其病因被认为与第一和第二臂弓闭合时,在子宫内生命的第三和第四周,在中线保留的上皮残留组织有关。其临床特征是触诊时呈橡胶状,边界清晰,在鳞状上皮内无皮肤附属物。最终诊断是通过组织病理学检查,在囊液腔或角蛋白中发现层状鳞状上皮。治疗方法通常为手术且无复发,最终诊断需通过组织病理学检查确认。本文报告一位5个月大的女性患者,其先天性表皮囊肿位于舌下腺导管附近的口腔底部。该病例经切除活检治疗,随访后无复发。
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引用次数: 0
Evaluation of the cephalometric centroid point in individuals before and after the pubertal growth peak 青春期生长高峰前后个体头形质心点的评价
Pub Date : 2022-01-01 DOI: 10.1590/1981-86372022000220190144
Joana Seung Ae Lee, H. Suzuki, Alana Binda Silva Costa, A. Garcez, S. Suzuki
ABSTRACT Objective: The purpose of this study was to evaluate the behavior of the Centroid point, known as the geometric center of the face, before and after the growth peak using lateral cephalometric x-ray. Methods: Sample consisted of 40 patients before and after pubertal peak of growth selected from the archive of the São Leopoldo Mandic Institute and Research Center, Campinas, Brazil. Anatomical structures, reference points, lines and planes were traced, and posteriorly a superimposition was performed using the palatal plane and a line perpendicular to this passage through the most posterior point of the pterygomaxillary fossa as reference. Later, the distance between the two centroid points (before and after the peak of puberty) was measured using the digital caliper, both horizontally and vertically. The palatal plane (x-axis) and a line perpendicular to this passage through the most posterior point of the pterygomaxilary fossa (y-axis) were chosen because they undergo minimal changes during growth. Results: No significant difference on the location of Centroid points on both X and Y axis (p >0.05) were observed between before and after the growth peak cephalometric tracings, showing an average change in positioning of 0.36mm on the X axis and 0.37mm on the Y axis. Conclusions: For this reason, this point can be indicated to be used clinically as a stable reference to evaluate craniofacial growth while performing superimposition methods.
【摘要】目的:本研究的目的是利用侧位头颅x线评估面部几何中心质心点在生长高峰前后的行为。方法:选取巴西坎皮纳斯市奥莱奥波尔多曼迪奇研究所和研究中心档案中青春期生长高峰前后的40例患者作为样本。绘制解剖结构、参考点、线和平面,并在后方使用腭面和垂直于该通道的线通过翼颌窝最后点作为参考进行叠加。然后,用数字卡尺水平和垂直测量两个质心点之间的距离(青春期高峰前后)。选择腭面(x轴)和一条垂直于这条穿过翼颌窝最后点的通道的线(y轴)是因为它们在生长过程中变化最小。结果:生长高峰头位显像前后质心点在X轴和Y轴上的位置差异无统计学意义(p >0.05), X轴和Y轴上的平均位置变化分别为0.36mm和0.37mm。结论:该点可作为临床应用叠加法评价颅面生长的稳定参考点。
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引用次数: 0
Epithelial-mesenchymal markers and their correlation with clinical aspects in odontogenic keratocysts 牙源性角化囊肿的上皮-间充质标志物及其与临床的相关性
Pub Date : 2022-01-01 DOI: 10.1590/1981-86372022005220210077
J. Vendruscolo, Mariana de SOUZA LESSA, Sergio OSSAMU IOSHII, J. Schussel, L. Sassi
ABSTRACT Objective: Odontogenic keratocysts have a high recurrence rate and aggressive clinical behavior. The event called epithelial-mesenchymal transition is a process in which the epithelial cell loses its epithelial characteristics and acquires properties typical of mesenchymal cells. Studies have already demonstrated that odontogenic keratocysts has expression of tumor markers, but the lack of clarification about its development mechanism and molecular composition makes the therapeutic options remain limited. The aim of this study is to evaluate the expression of epithelial-mesenchymal transition marker proteins in these lesions, correlating the expression of these proteins with clinical aspects of each case. Methods: Patients with odontogenic keratocysts diagnoses, treated by the Department of Oral and Maxillofacial Surgery of the Erasto Gaertner Hospital, Curitiba, Brazil in the period between 2016 and 2019 were evaluated by immunohistochemical analysis, to assess the expression of epithelial-mesenchymal transition markers (Vimentin, beta-catenin and E-cadherin) by qualitative analysis. Results: Eighteen patients were included, with a mean age of 43 years, and most of them were male. The mandible was more affected than the maxilla. No association between the clinical characteristics of the cysts and the immunohistochemical profile for epithelial-mesenchymal transition proteins was observed. Conclusion: The positivity of E-cadherin and negativity of vimentin demonstrates that its function is preserved. Loss of function of E-cadherin is associated with worse prognosis. The identification of the epithelial-mesenchymal transition process as a prognostic marker for odontogenic cysts and tumors could be an important tool for defining treatment.
摘要目的:牙源性角化囊肿具有高复发率和侵袭性临床行为。上皮-间充质转化是上皮细胞失去其上皮特性并获得间充质细胞典型特性的过程。研究表明,牙源性角化囊肿具有肿瘤标志物的表达,但其发生机制和分子组成尚不明确,使得治疗选择仍然有限。本研究的目的是评估这些病变中上皮-间质过渡标记蛋白的表达,并将这些蛋白的表达与每个病例的临床方面联系起来。方法:对2016 - 2019年在巴西库里蒂巴市Erasto Gaertner医院口腔颌面外科治疗的牙源性角化囊肿患者进行免疫组化分析,定性分析上皮-间质转化标志物(Vimentin、β -catenin、E-cadherin)的表达情况。结果:纳入18例患者,平均年龄43岁,男性居多。下颌骨比上颌骨受影响更大。没有观察到囊肿的临床特征与上皮-间充质转化蛋白的免疫组织化学特征之间的关联。结论:E-cadherin呈阳性,而vimentin呈阴性,表明其功能得以保留。e -钙粘蛋白功能丧失与预后不良相关。鉴定上皮-间质转化过程作为牙源性囊肿和肿瘤的预后标志物可能是确定治疗的重要工具。
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引用次数: 0
期刊
RGO Revista Gaucha de Odontologia
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