Pub Date : 2022-01-01DOI: 10.1590/1981-86372022005220210077
J. Vendruscolo, Mariana de SOUZA LESSA, Sergio OSSAMU IOSHII, J. Schussel, L. Sassi
ABSTRACT Objective: Odontogenic keratocysts have a high recurrence rate and aggressive clinical behavior. The event called epithelial-mesenchymal transition is a process in which the epithelial cell loses its epithelial characteristics and acquires properties typical of mesenchymal cells. Studies have already demonstrated that odontogenic keratocysts has expression of tumor markers, but the lack of clarification about its development mechanism and molecular composition makes the therapeutic options remain limited. The aim of this study is to evaluate the expression of epithelial-mesenchymal transition marker proteins in these lesions, correlating the expression of these proteins with clinical aspects of each case. Methods: Patients with odontogenic keratocysts diagnoses, treated by the Department of Oral and Maxillofacial Surgery of the Erasto Gaertner Hospital, Curitiba, Brazil in the period between 2016 and 2019 were evaluated by immunohistochemical analysis, to assess the expression of epithelial-mesenchymal transition markers (Vimentin, beta-catenin and E-cadherin) by qualitative analysis. Results: Eighteen patients were included, with a mean age of 43 years, and most of them were male. The mandible was more affected than the maxilla. No association between the clinical characteristics of the cysts and the immunohistochemical profile for epithelial-mesenchymal transition proteins was observed. Conclusion: The positivity of E-cadherin and negativity of vimentin demonstrates that its function is preserved. Loss of function of E-cadherin is associated with worse prognosis. The identification of the epithelial-mesenchymal transition process as a prognostic marker for odontogenic cysts and tumors could be an important tool for defining treatment.
{"title":"Epithelial-mesenchymal markers and their correlation with clinical aspects in odontogenic keratocysts","authors":"J. Vendruscolo, Mariana de SOUZA LESSA, Sergio OSSAMU IOSHII, J. Schussel, L. Sassi","doi":"10.1590/1981-86372022005220210077","DOIUrl":"https://doi.org/10.1590/1981-86372022005220210077","url":null,"abstract":"ABSTRACT Objective: Odontogenic keratocysts have a high recurrence rate and aggressive clinical behavior. The event called epithelial-mesenchymal transition is a process in which the epithelial cell loses its epithelial characteristics and acquires properties typical of mesenchymal cells. Studies have already demonstrated that odontogenic keratocysts has expression of tumor markers, but the lack of clarification about its development mechanism and molecular composition makes the therapeutic options remain limited. The aim of this study is to evaluate the expression of epithelial-mesenchymal transition marker proteins in these lesions, correlating the expression of these proteins with clinical aspects of each case. Methods: Patients with odontogenic keratocysts diagnoses, treated by the Department of Oral and Maxillofacial Surgery of the Erasto Gaertner Hospital, Curitiba, Brazil in the period between 2016 and 2019 were evaluated by immunohistochemical analysis, to assess the expression of epithelial-mesenchymal transition markers (Vimentin, beta-catenin and E-cadherin) by qualitative analysis. Results: Eighteen patients were included, with a mean age of 43 years, and most of them were male. The mandible was more affected than the maxilla. No association between the clinical characteristics of the cysts and the immunohistochemical profile for epithelial-mesenchymal transition proteins was observed. Conclusion: The positivity of E-cadherin and negativity of vimentin demonstrates that its function is preserved. Loss of function of E-cadherin is associated with worse prognosis. The identification of the epithelial-mesenchymal transition process as a prognostic marker for odontogenic cysts and tumors could be an important tool for defining treatment.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82026163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1590/1981-86372022000320190161
Claudia da Silva Oliveira, Janielma Azevedo Silva, H. H. A. Morais, Erasmo Freitas de SOUZA JUNIOR
ABSTRACT Injuries caused by firearm projectiles in the head and neck region generally imply severe morbidity and mortality, representing an important public health problem. These injuries can be classified as: penetrating, perforating and avulsive, and the latter is the most worrisome, because they are caused by high-velocity projectiles. Low-velocity projectiles commonly cause penetrating injuries, sometimes remaining lodged in tissues, and their removal may or may not be indicated, depending on factors such as location and severity of the lesion. This paper presents the report of three clinical cases that address injuries caused by low-velocity firearm projectiles, in which they had the indication of this artifact removal, addressing the pre, trans and post-surgery procedures. And we point out that full tactical, technical and theoretical domains are required from the Oral-Maxillofacial Surgeons for being successful in the planning and success in the treatment of these lesions.
{"title":"Ballistic projectiles removal in head and neck region","authors":"Claudia da Silva Oliveira, Janielma Azevedo Silva, H. H. A. Morais, Erasmo Freitas de SOUZA JUNIOR","doi":"10.1590/1981-86372022000320190161","DOIUrl":"https://doi.org/10.1590/1981-86372022000320190161","url":null,"abstract":"ABSTRACT Injuries caused by firearm projectiles in the head and neck region generally imply severe morbidity and mortality, representing an important public health problem. These injuries can be classified as: penetrating, perforating and avulsive, and the latter is the most worrisome, because they are caused by high-velocity projectiles. Low-velocity projectiles commonly cause penetrating injuries, sometimes remaining lodged in tissues, and their removal may or may not be indicated, depending on factors such as location and severity of the lesion. This paper presents the report of three clinical cases that address injuries caused by low-velocity firearm projectiles, in which they had the indication of this artifact removal, addressing the pre, trans and post-surgery procedures. And we point out that full tactical, technical and theoretical domains are required from the Oral-Maxillofacial Surgeons for being successful in the planning and success in the treatment of these lesions.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83782323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1590/1981-8637202200212020179
Michel Faivro Almeida Serpa, B. Sotto-Maior, C. Francischone, M. A. Ribeiro, Wellington Lima
ABSTRACT Objective: Evaluate the biomechanical behavior of the influence of different internal angles of conical prosthetic connections in fixed partial prostheses of three elements, through the tridimensional finite element method. Methods: Two different models of segment of the posterior portion of the mandible, with two implants with conical connections at angulations of 11.5 and 16 degrees. Afterwards, and occlusal load of 180N was used, and divided into 2 points of application on the premolar, and 400N divided into 5 points of application on the molar. Data were acquired as the tensile, compressive and shear stresses on cortical and medullary bone, and von Mises stresses on implants and prosthetic components of two implants in both in three-unit fixed partial prosthesis. In the quantitative analysis, both in cortical and medullary bone, the tension peaks in tensile, compression, and shear forces were higher for the CM16 group. Results: When analyzing qualitatively, the cortical and medullary bones presented a greater stress around the implant platform with a higher incidence in the implant in the molar region. In the von Misses analysis in both groups, the tensions were concentrated in the cervical region of the implants, in the first threads, in the premolar and molar regions. Regarding prosthetic pillars, the stress concentration was located in the region of contact with the implant. Conclusion: The increased angulation of conicity of the internal conical connections represents a determinant factor to increase in stress concentration in the implants, prosthetic components and adjacent structures, such as the cortical and medullary bone.
{"title":"Biomechanical behavior of implants with prosthetic connection of the morse (Cone) type, with different angulations at the implant-abutment interface in multiple dental prostheses: a finite element study","authors":"Michel Faivro Almeida Serpa, B. Sotto-Maior, C. Francischone, M. A. Ribeiro, Wellington Lima","doi":"10.1590/1981-8637202200212020179","DOIUrl":"https://doi.org/10.1590/1981-8637202200212020179","url":null,"abstract":"ABSTRACT Objective: Evaluate the biomechanical behavior of the influence of different internal angles of conical prosthetic connections in fixed partial prostheses of three elements, through the tridimensional finite element method. Methods: Two different models of segment of the posterior portion of the mandible, with two implants with conical connections at angulations of 11.5 and 16 degrees. Afterwards, and occlusal load of 180N was used, and divided into 2 points of application on the premolar, and 400N divided into 5 points of application on the molar. Data were acquired as the tensile, compressive and shear stresses on cortical and medullary bone, and von Mises stresses on implants and prosthetic components of two implants in both in three-unit fixed partial prosthesis. In the quantitative analysis, both in cortical and medullary bone, the tension peaks in tensile, compression, and shear forces were higher for the CM16 group. Results: When analyzing qualitatively, the cortical and medullary bones presented a greater stress around the implant platform with a higher incidence in the implant in the molar region. In the von Misses analysis in both groups, the tensions were concentrated in the cervical region of the implants, in the first threads, in the premolar and molar regions. Regarding prosthetic pillars, the stress concentration was located in the region of contact with the implant. Conclusion: The increased angulation of conicity of the internal conical connections represents a determinant factor to increase in stress concentration in the implants, prosthetic components and adjacent structures, such as the cortical and medullary bone.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"162 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86442788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1590/1981-86372022004920210087
R. Gomes, Andressa Cristina da Silva Queiroz, V. Figueiredo
ABSTRACT With the consolidation of Adhesive Dentistry and the emergence of new aesthetic restorative materials, Endocrown has been studied as a rehabilitative option for endodontically treated teeth. This is an Integrative Literature Review, based on the PICO strategy, with articles selected from the databases of PubMed and BVS, with a period of time from 2011-2021. The database search strategy included the following keywords: (“Endocrown” OR “Endocrowns” OR “Endocrown Restoration” OR “no-post buildup” OR “adhesive endodontic crowns”). Inclusion criteria for this review were laboratory studies and observational clinical studies. Exclusion criteria were clinical case studies, literature review, systematic review and meta-analysis. Furthermore, articles that addressed only intraradicular retainers or other restorative strategies were also excluded. The selection of articles was based on abstracts. 5 articles were selected for analysis, obtaining data on the endocrown in relation to the stress on the tooth structure, aging, marginal adaptation, fracture resistance, endocrown versus conventional crown and integrity of the tooth structure. The findings in the literature are not yet established regarding the integrity of the dental structure, as the supporting evidence is limited. Only 1 in vitro article showed that dental failures in endocrowns are more favorable to repair and another 2 in silico studies show lower stress distribution on enamel, dentin and cement in the same restoration. Moreover, the restorative material seems to influence the possibility of fracture for both conventional crowns and endocrown restorations.
{"title":"Endocrown as a restorative strategy in endodontically treated teeth: an integrative literature review","authors":"R. Gomes, Andressa Cristina da Silva Queiroz, V. Figueiredo","doi":"10.1590/1981-86372022004920210087","DOIUrl":"https://doi.org/10.1590/1981-86372022004920210087","url":null,"abstract":"ABSTRACT With the consolidation of Adhesive Dentistry and the emergence of new aesthetic restorative materials, Endocrown has been studied as a rehabilitative option for endodontically treated teeth. This is an Integrative Literature Review, based on the PICO strategy, with articles selected from the databases of PubMed and BVS, with a period of time from 2011-2021. The database search strategy included the following keywords: (“Endocrown” OR “Endocrowns” OR “Endocrown Restoration” OR “no-post buildup” OR “adhesive endodontic crowns”). Inclusion criteria for this review were laboratory studies and observational clinical studies. Exclusion criteria were clinical case studies, literature review, systematic review and meta-analysis. Furthermore, articles that addressed only intraradicular retainers or other restorative strategies were also excluded. The selection of articles was based on abstracts. 5 articles were selected for analysis, obtaining data on the endocrown in relation to the stress on the tooth structure, aging, marginal adaptation, fracture resistance, endocrown versus conventional crown and integrity of the tooth structure. The findings in the literature are not yet established regarding the integrity of the dental structure, as the supporting evidence is limited. Only 1 in vitro article showed that dental failures in endocrowns are more favorable to repair and another 2 in silico studies show lower stress distribution on enamel, dentin and cement in the same restoration. Moreover, the restorative material seems to influence the possibility of fracture for both conventional crowns and endocrown restorations.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81511735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1590/1981-86372022003920210055
Anayla Oliveira da Silva, Amanda Barbosa de Godoy, Luanna Maria Rocha Caldas da Silva, Layza Tércia Marcelino Leite, Stephanie do Carmo Gurgel, Ana Larissa Fernandes de Holanda Soares
ABSTRACT Cancer is a disease that has disordered cell growth with the formation of tumors. The most common types of childhood and adolescent childhood cancer are leukemias, tumors of the central nervous system, and lymphomas. Objective: To evaluate the knowledge of those responsible for oral health practices and care of children assisted in the Polyclinic of Natal, who underwent antineoplastic treatment. In addition to knowing the main oral health practices performed by those responsible. Methods: A quantitative and descriptive cross-sectional study, carried out in the Natal Polyclinic Unit (Liga Norte Riograndense Contra o Câncer), located in Rio Grande do Norte. The sample consisted of 41 questionnaires applied individually to those responsible for the children aged 0 to 12 years who underwent cancer treatment, during March and April 2018. Results: It was found that 51% of the responsible identified some oral health problem in their children, and 43.9% of the children had already been affected by mucositis. Of the 41 hospitalized patients, 90.2% were accompanied by a dental surgeon during the antineoplastic treatment. Conclusion: The responsible ones had a great perception of the children’s oral health problems and knew the importance of the participation of the dentist during the are treatment. There is a need for more research on the subject, to establish a care protocol with oral hygiene of children hospitalized with cancer.
癌症是一种细胞生长紊乱并形成肿瘤的疾病。儿童和青少年最常见的癌症类型是白血病、中枢神经系统肿瘤和淋巴瘤。目的:评估在纳塔尔综合诊所协助接受抗肿瘤治疗的儿童的口腔卫生实践和护理人员的知识。除了了解责任人的主要口腔卫生做法外。方法:在位于北里奥格兰德州的纳塔尔综合诊所(Liga Norte Riograndense Contra o c ncer)进行了一项定量和描述性横断面研究。该样本由41份问卷组成，这些问卷分别针对2018年3月至4月期间接受癌症治疗的0至12岁儿童的负责人。结果:51%的家长认为自己的孩子存在口腔健康问题，43.9%的家长已经出现过口腔黏膜炎。在41例住院患者中，90.2%的患者在抗肿瘤治疗期间有牙科医生陪同。结论:负责任的家长对儿童的口腔健康问题有较强的认知，了解牙医参与治疗的重要性。需要对这一主题进行更多的研究，以建立癌症住院儿童口腔卫生护理方案。
{"title":"Oral health: knowledge of those responsible for hospitalized children with cancer","authors":"Anayla Oliveira da Silva, Amanda Barbosa de Godoy, Luanna Maria Rocha Caldas da Silva, Layza Tércia Marcelino Leite, Stephanie do Carmo Gurgel, Ana Larissa Fernandes de Holanda Soares","doi":"10.1590/1981-86372022003920210055","DOIUrl":"https://doi.org/10.1590/1981-86372022003920210055","url":null,"abstract":"ABSTRACT Cancer is a disease that has disordered cell growth with the formation of tumors. The most common types of childhood and adolescent childhood cancer are leukemias, tumors of the central nervous system, and lymphomas. Objective: To evaluate the knowledge of those responsible for oral health practices and care of children assisted in the Polyclinic of Natal, who underwent antineoplastic treatment. In addition to knowing the main oral health practices performed by those responsible. Methods: A quantitative and descriptive cross-sectional study, carried out in the Natal Polyclinic Unit (Liga Norte Riograndense Contra o Câncer), located in Rio Grande do Norte. The sample consisted of 41 questionnaires applied individually to those responsible for the children aged 0 to 12 years who underwent cancer treatment, during March and April 2018. Results: It was found that 51% of the responsible identified some oral health problem in their children, and 43.9% of the children had already been affected by mucositis. Of the 41 hospitalized patients, 90.2% were accompanied by a dental surgeon during the antineoplastic treatment. Conclusion: The responsible ones had a great perception of the children’s oral health problems and knew the importance of the participation of the dentist during the are treatment. There is a need for more research on the subject, to establish a care protocol with oral hygiene of children hospitalized with cancer.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88382818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1590/1981-863720200004520210106
Maria Cristina Pedrazini, Larissa Pavanello, A. Pelegrine
ABSTRACT The COVID-19 has challenged the professions and Implantology also has its challenges in the pandemic. Several factors can interfere with the osseointegration process and more associated factors, greater the interference risks. Risk assessment in the therapy indication is the main decision to define the best technique, the best biomaterial, the best surgical access and the best moment to intervene. The purpose of this review was to investigate and synthesize the scientific evidence on the factors that may interfere with dental implant therapy in the midst of pandemic. The literature was reviewed in databases such as PubMed, Web of Science, Sciello and Google Scholar using the keywords “COVID-19”, “pandemic”, “risk factors”, “impact factor”, “dental implants”, “dentistry”, “oral health”, “osseointegration”, “bone metabolism”, “drug risk factors”, “chronic stress”, “antidepressants”, “zinc”, “hydroxychloroquine”, “ivermectin”, “vitamins”, “corticosteroids”, “surgical risks” and “disinfection”. The present review showed that chronic stress and depression caused by the pandemic, the consequent use of antidepressants, the use of prophylactic and therapeutic drugs such zinc, vitamin D, hydroxychloroquine and corticosteroids, can interfere with bone metabolism and consequently in osseointegration establishment and/or maintenance. Any osseointegrable biomaterial can be influenced by systemic factors and drugs’ actions that can affect the homeostasis of the inflammatory process, cell proliferation and bone remodeling. These factors’ influence on dental implant therapy should be investigated through new reviews, observational studies and randomized clinical trial.
新冠肺炎疫情给专业带来了挑战，种植医学也面临着挑战。干扰骨整合过程的因素有多种，相关因素越多，干扰风险越大。治疗指征中的风险评估是确定最佳技术、最佳生物材料、最佳手术途径和最佳干预时机的主要决定因素。本综述的目的是调查和综合在大流行期间可能干扰种植牙治疗的因素的科学证据。在PubMed、Web of Science、Sciello和谷歌Scholar等数据库中检索相关文献，检索关键词为“COVID-19”、“大流行”、“危险因素”、“影响因素”、“牙种植体”、“牙科”、“口腔健康”、“骨整合”、“骨代谢”、“药物危险因素”、“慢性压力”、“抗抑郁药”、“锌”、“羟氯喹”、“伊维菌素”、“维生素”、“皮质类固醇”、“手术风险”和“消毒”。目前的审查表明，大流行引起的慢性压力和抑郁，随之而来的抗抑郁药的使用，锌、维生素D、羟氯喹和皮质类固醇等预防性和治疗性药物的使用，可干扰骨代谢，从而影响骨整合的建立和/或维持。任何可骨整合的生物材料都会受到全身因素和药物作用的影响，从而影响炎症过程、细胞增殖和骨重塑的稳态。这些因素对种植牙治疗的影响需要通过新的综述、观察性研究和随机临床试验来研究。
{"title":"The possible impact of COVID-19 pandemic on dental implant therapy: narrative review","authors":"Maria Cristina Pedrazini, Larissa Pavanello, A. Pelegrine","doi":"10.1590/1981-863720200004520210106","DOIUrl":"https://doi.org/10.1590/1981-863720200004520210106","url":null,"abstract":"ABSTRACT The COVID-19 has challenged the professions and Implantology also has its challenges in the pandemic. Several factors can interfere with the osseointegration process and more associated factors, greater the interference risks. Risk assessment in the therapy indication is the main decision to define the best technique, the best biomaterial, the best surgical access and the best moment to intervene. The purpose of this review was to investigate and synthesize the scientific evidence on the factors that may interfere with dental implant therapy in the midst of pandemic. The literature was reviewed in databases such as PubMed, Web of Science, Sciello and Google Scholar using the keywords “COVID-19”, “pandemic”, “risk factors”, “impact factor”, “dental implants”, “dentistry”, “oral health”, “osseointegration”, “bone metabolism”, “drug risk factors”, “chronic stress”, “antidepressants”, “zinc”, “hydroxychloroquine”, “ivermectin”, “vitamins”, “corticosteroids”, “surgical risks” and “disinfection”. The present review showed that chronic stress and depression caused by the pandemic, the consequent use of antidepressants, the use of prophylactic and therapeutic drugs such zinc, vitamin D, hydroxychloroquine and corticosteroids, can interfere with bone metabolism and consequently in osseointegration establishment and/or maintenance. Any osseointegrable biomaterial can be influenced by systemic factors and drugs’ actions that can affect the homeostasis of the inflammatory process, cell proliferation and bone remodeling. These factors’ influence on dental implant therapy should be investigated through new reviews, observational studies and randomized clinical trial.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89014645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1590/1981-86372022000920200108
Carolina Ruppel, Nathália Christina Stremel Martins, Marceli Dias Ferreira, Larissa Camargo, M. Claudino, E. Campagnoli
ABSTRACT Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are adverse reactions, usually medicine-related, in which extensive and painful mucocutaneous lesions are formed. Oral lesions are characterized by the presence of erosions and ulcers. The treatment usually requires intensive care in a hospital setting, where the Dentist is essential in the multidisciplinary team, as he will act in the treatment of oral lesions. In this article, a 26-year-old female patient was reported, who presented TEN-compatible mucocutaneous lesions associated with the drug Phenytoin and required admission to a Teaching Hospital. The treatment consisted of the immediate suspension of the Phenytoin use and systemic therapy with corticosteroids and immunosuppressants. Oral lesions were monitored by the hospital dentistry team. The procedures adopted were: oral hygiene with 0.12% non-alcoholic Chlorhexidine Digluconate solution, hydration of the oral tissue with an essential fatty acid, application of frozen chamomile tea, and prescription of topical Triamcinolone Acetonide. Also, low-level laser therapy sessions (red and infrared) were performed. Oral lesions evolved with significant improvement. In this case, the importance of the Dentist in the multi-professional team is demonstrated. Although there is no protocol, the procedures used in the present case can be an alternative to therapies used in SSJ and TEN oral lesions.
{"title":"Dental management in the Intensive Care Unit in the treatment of toxic epidermal necrolysis associated with phenytoin: case report","authors":"Carolina Ruppel, Nathália Christina Stremel Martins, Marceli Dias Ferreira, Larissa Camargo, M. Claudino, E. Campagnoli","doi":"10.1590/1981-86372022000920200108","DOIUrl":"https://doi.org/10.1590/1981-86372022000920200108","url":null,"abstract":"ABSTRACT Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are adverse reactions, usually medicine-related, in which extensive and painful mucocutaneous lesions are formed. Oral lesions are characterized by the presence of erosions and ulcers. The treatment usually requires intensive care in a hospital setting, where the Dentist is essential in the multidisciplinary team, as he will act in the treatment of oral lesions. In this article, a 26-year-old female patient was reported, who presented TEN-compatible mucocutaneous lesions associated with the drug Phenytoin and required admission to a Teaching Hospital. The treatment consisted of the immediate suspension of the Phenytoin use and systemic therapy with corticosteroids and immunosuppressants. Oral lesions were monitored by the hospital dentistry team. The procedures adopted were: oral hygiene with 0.12% non-alcoholic Chlorhexidine Digluconate solution, hydration of the oral tissue with an essential fatty acid, application of frozen chamomile tea, and prescription of topical Triamcinolone Acetonide. Also, low-level laser therapy sessions (red and infrared) were performed. Oral lesions evolved with significant improvement. In this case, the importance of the Dentist in the multi-professional team is demonstrated. Although there is no protocol, the procedures used in the present case can be an alternative to therapies used in SSJ and TEN oral lesions.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80245056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1590/1981-86372022004220210001
Danielle Monsores Vieira, F. Silva, M. Diniz, M. C. Ferreira, M. Santos, R. Guaré
ABSTRACT Shprintzen-Goldberg craniosynostosis syndrome, characterized by craniosynostosis and marfanoid habitus, is a very rare entity described in 75 individuals worldwide. This study aimed to present a case report of a 6-year-old female Brazilian child with Shprintzen-Goldberg’s craniosynostosis syndrome. We described the craniofacial and oral characteristics and its clinical management, comparing to the existing literature. The patient presented with intellectual disability, craniosynostosis, ocular proptosis, low-set anomalous ears, and other skeletal and connective tissue defects. Oral features included malocclusion, micrognathia, pseudo-cleft palate, dental caries, and inefficient biofilm control. The treatment started with guidance on cariogenic foods, oral hygiene, and an indication to discontinue bottle feeding. Subsequently, the carious lesions were restored with composite resins, and the patient was referred for orthopedic surgery, orthodontic treatment, speech therapy, and nutritional counseling. The patient was followed for 5 years. This case report emphasizes the importance of knowing the craniofacial and oral characteristics for the diagnosis and clinical management of a female child with a rare Shprintzen-Goldberg’s craniosynostosis syndrome. The case also highlights the need for oral health care in individuals with intellectual disabilities.
{"title":"Shprintzen-goldberg craniosynostosis: craniofacial and oral characteristics, diagnosis, and clinical management of a very rare syndrome","authors":"Danielle Monsores Vieira, F. Silva, M. Diniz, M. C. Ferreira, M. Santos, R. Guaré","doi":"10.1590/1981-86372022004220210001","DOIUrl":"https://doi.org/10.1590/1981-86372022004220210001","url":null,"abstract":"ABSTRACT Shprintzen-Goldberg craniosynostosis syndrome, characterized by craniosynostosis and marfanoid habitus, is a very rare entity described in 75 individuals worldwide. This study aimed to present a case report of a 6-year-old female Brazilian child with Shprintzen-Goldberg’s craniosynostosis syndrome. We described the craniofacial and oral characteristics and its clinical management, comparing to the existing literature. The patient presented with intellectual disability, craniosynostosis, ocular proptosis, low-set anomalous ears, and other skeletal and connective tissue defects. Oral features included malocclusion, micrognathia, pseudo-cleft palate, dental caries, and inefficient biofilm control. The treatment started with guidance on cariogenic foods, oral hygiene, and an indication to discontinue bottle feeding. Subsequently, the carious lesions were restored with composite resins, and the patient was referred for orthopedic surgery, orthodontic treatment, speech therapy, and nutritional counseling. The patient was followed for 5 years. This case report emphasizes the importance of knowing the craniofacial and oral characteristics for the diagnosis and clinical management of a female child with a rare Shprintzen-Goldberg’s craniosynostosis syndrome. The case also highlights the need for oral health care in individuals with intellectual disabilities.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74981829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1590/1981-86372022001420200225
A. Sanches, Alessandra Laís Pinho Valente Pires, T. C. F. Ramos, Beatriz de Araújo Frota, Hortencia Resende dos Santos DELLA CELLA, M. Oliveira, V. S. Freitas, G. B. Martins
ABSTRACT Objective: Civatte bodies are colloid bodies of apoptotic keratinocytes located at the dermoepidermal junction and are common in several dermatoses, including lichen planus lesions. The present study aimed to determine the presence of Civatte bodies in a sample of incisional biopsies obtained from patients diagnosed with oral lichen planus. Methods: A retrospective cross-sectional study, carried out with 34 slides stained with hematoxylin-eosin from the archive of an Oral Pathology Laboratory of a Higher Education Institution. The sample obtained was classified into white and red lesions from the available clinical data. Histological analyses were performed under a light microscope, with 10x and 40x objectives, identifying the presence or absence of Civatte bodies. Results: Colloid bodies were present in 73.5% the total sample studied and in 74.2% white lesions. Conclusion: The Civatte bodies were frequent in all samples analysed and should thus be considered a criterion for histological diagnosis in lesions of Oral Lichen Planus.
{"title":"Presence of Civatte Bodies in an oral lichen planus incisional biopsy sample","authors":"A. Sanches, Alessandra Laís Pinho Valente Pires, T. C. F. Ramos, Beatriz de Araújo Frota, Hortencia Resende dos Santos DELLA CELLA, M. Oliveira, V. S. Freitas, G. B. Martins","doi":"10.1590/1981-86372022001420200225","DOIUrl":"https://doi.org/10.1590/1981-86372022001420200225","url":null,"abstract":"ABSTRACT Objective: Civatte bodies are colloid bodies of apoptotic keratinocytes located at the dermoepidermal junction and are common in several dermatoses, including lichen planus lesions. The present study aimed to determine the presence of Civatte bodies in a sample of incisional biopsies obtained from patients diagnosed with oral lichen planus. Methods: A retrospective cross-sectional study, carried out with 34 slides stained with hematoxylin-eosin from the archive of an Oral Pathology Laboratory of a Higher Education Institution. The sample obtained was classified into white and red lesions from the available clinical data. Histological analyses were performed under a light microscope, with 10x and 40x objectives, identifying the presence or absence of Civatte bodies. Results: Colloid bodies were present in 73.5% the total sample studied and in 74.2% white lesions. Conclusion: The Civatte bodies were frequent in all samples analysed and should thus be considered a criterion for histological diagnosis in lesions of Oral Lichen Planus.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73059589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1590/1981-86372022002520200226
C. Aguiar, Milena Mello Varela Ayres de Melo Pinheiro, Rodrigo Henrique Mello Varela Ayres de Melo, V. Melo, Lohana Maylane Aquino Correia de Lima, Arnaldo de França Caldas Júnior, R. Melo
ABSTRACT Basal cell carcinoma is the most common type among skin cancers. It occurs in basal cells and is primarily caused by sun exposure. It mainly affects elderly people, mainly man, in exposed areas of the body and is diagnosed through biopsy. The choice of treatment depends on the type, size, location and depth of penetration, the patient’s age, health conditions and potential aesthetic outcome. The present study aims to evidence, through a case report, the aesthetic and functional importance of the cutaneous transplant technique in cases of tissue loss in the face region by Basal cell carcinoma. A 56-year-old female patient, leukoderma, attended the Maxillofacial Surgery and Traumatology service of the Federal University of Pernambuco, complaining of asymmetry in the nasal dorsum region, with differentiated staining and raised edges. In anamnesis time she reported having suffered sun exposure for long periods. The patient underwent an incisional biopsy and subsequently, with a diagnosis of basal cell carcinoma, a resection of the lesion followed by skin autografting. Good acceptances of the skin flap as well as excellent aesthetic result were attained. The autogenous grafts use has shown satisfactory aesthetic results for remaining coverage after the lesion excision.
{"title":"Autograft reconstruction of nasal dorsum in cutaneous neoplasia treatment","authors":"C. Aguiar, Milena Mello Varela Ayres de Melo Pinheiro, Rodrigo Henrique Mello Varela Ayres de Melo, V. Melo, Lohana Maylane Aquino Correia de Lima, Arnaldo de França Caldas Júnior, R. Melo","doi":"10.1590/1981-86372022002520200226","DOIUrl":"https://doi.org/10.1590/1981-86372022002520200226","url":null,"abstract":"ABSTRACT Basal cell carcinoma is the most common type among skin cancers. It occurs in basal cells and is primarily caused by sun exposure. It mainly affects elderly people, mainly man, in exposed areas of the body and is diagnosed through biopsy. The choice of treatment depends on the type, size, location and depth of penetration, the patient’s age, health conditions and potential aesthetic outcome. The present study aims to evidence, through a case report, the aesthetic and functional importance of the cutaneous transplant technique in cases of tissue loss in the face region by Basal cell carcinoma. A 56-year-old female patient, leukoderma, attended the Maxillofacial Surgery and Traumatology service of the Federal University of Pernambuco, complaining of asymmetry in the nasal dorsum region, with differentiated staining and raised edges. In anamnesis time she reported having suffered sun exposure for long periods. The patient underwent an incisional biopsy and subsequently, with a diagnosis of basal cell carcinoma, a resection of the lesion followed by skin autografting. Good acceptances of the skin flap as well as excellent aesthetic result were attained. The autogenous grafts use has shown satisfactory aesthetic results for remaining coverage after the lesion excision.","PeriodicalId":30069,"journal":{"name":"RGO Revista Gaucha de Odontologia","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83121310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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