Najmeh Dezhkam, Mohammad Reza Zarbakhsh Bahri, Ali Khaneh Keshi
Background: Immature behaviors, including impulsivity and lack of control lead to personal and social pathologies, such as addiction. Methods: This meta-analysis study aimed to evaluate the effect of impulsivity on addition and addictive tendencies. This comprehensive interdisciplinary quantitative meta-analysis integrated the research findings regarding the effect of impulsivity on addiction and addictive tendencies based on secondary data. A checklist was developed for collecting data based on the article title, author specifications, publication year, setting, research type, hypothesis, data collection instrument, statistical population, sample size, significance level, and probability value to avoid bias in the study selection protocol. Results: The results of studies were divided into nine databases to calculate the effect size, and finally, 11 studies were analyzed. The descriptive data analysis and effect size calculation were performed in the Comprehensive Meta-Analysis Software (CMA) version 2.0. Based on the fixed-effects model, 0.153 of the studies contributed significantly to the actual fixed effect sizes. The difference in effect sizes was due to sampling error. The random-effects model (0.202) suggested the independence of the studies (P < 0.001) with moderate robustness. Conclusions: According to the results, the behavioral construct of impulsivity significantly and positively affected addictive behaviors and tendencies. Therefore, the mediating effect of impulsivity, promote resilience, and train protective strategies for individuals prone to addiction should be controlled to improve mental health quality and develop social, communication, and life skills.
{"title":"The Effect of Impulsivity on Addition and Addictive Tendencies: A Meta-analysis","authors":"Najmeh Dezhkam, Mohammad Reza Zarbakhsh Bahri, Ali Khaneh Keshi","doi":"10.5812/jhrt-120846","DOIUrl":"https://doi.org/10.5812/jhrt-120846","url":null,"abstract":"Background: Immature behaviors, including impulsivity and lack of control lead to personal and social pathologies, such as addiction. Methods: This meta-analysis study aimed to evaluate the effect of impulsivity on addition and addictive tendencies. This comprehensive interdisciplinary quantitative meta-analysis integrated the research findings regarding the effect of impulsivity on addiction and addictive tendencies based on secondary data. A checklist was developed for collecting data based on the article title, author specifications, publication year, setting, research type, hypothesis, data collection instrument, statistical population, sample size, significance level, and probability value to avoid bias in the study selection protocol. Results: The results of studies were divided into nine databases to calculate the effect size, and finally, 11 studies were analyzed. The descriptive data analysis and effect size calculation were performed in the Comprehensive Meta-Analysis Software (CMA) version 2.0. Based on the fixed-effects model, 0.153 of the studies contributed significantly to the actual fixed effect sizes. The difference in effect sizes was due to sampling error. The random-effects model (0.202) suggested the independence of the studies (P < 0.001) with moderate robustness. Conclusions: According to the results, the behavioral construct of impulsivity significantly and positively affected addictive behaviors and tendencies. Therefore, the mediating effect of impulsivity, promote resilience, and train protective strategies for individuals prone to addiction should be controlled to improve mental health quality and develop social, communication, and life skills.","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"321 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122219180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Jafari, Hadis Fattahi, Leila Sheikhy, Sodabeh Eskandari, M. Mirzaei-Alavijeh
Background: Gestational diabetes is the most prevalent metabolic disorder during pregnancy. Therefore, it is essential to recognize its outcomes and complications. Objectives: The present study aimed to compare pregnancy outcomes in diabetic and healthy women. Methods: This case-control study was conducted on 380 diabetic and healthy women, who were divided into two groups of 190, at Moatazedi Hospital in Kermanshah, Iran in 2019. The participants were selected via convenience sampling. Data were collected using a researcher-made checklist designed based on the family records of the participants. Data analysis was performed in SPSS version 22 using chi-square, Fisher’s exact test, and the Mann-Whitney U test. Results: A significant correlation was observed between gestational age, maternal body mass index, birth weight, infant’s height, mode of delivery (P < 0.01), preeclampsia (P = 0.01), and the family history of diabetes (P = 0.03) in the diabetic and healthy pregnant women. However, no significant correlation was denoted between the five- and 10-minute Apgar scores, maternal disorders, and maternal care during pregnancy. Conclusions: According to the results, gestational diabetes is associated with an increase rate of complications, which must be diminished through prevention and disease control to promote maternal and neonatal health.
背景:妊娠期糖尿病是妊娠期最常见的代谢紊乱。因此，必须认识到其结果和并发症。目的:本研究旨在比较糖尿病妇女和健康妇女的妊娠结局。方法:本病例对照研究于2019年在伊朗克尔曼沙阿Moatazedi医院将380名糖尿病和健康女性分为两组，每组190人。参与者采用方便抽样的方式进行选择。数据收集使用研究者根据参与者的家庭记录设计的检查表。数据分析采用SPSS version 22，采用卡方检验、Fisher精确检验和Mann-Whitney U检验。结果:糖尿病孕妇与健康孕妇的胎龄、母体体重指数、出生体重、婴儿身高、分娩方式(P < 0.01)、子痫前期(P = 0.01)、糖尿病家族史(P = 0.03)均有显著相关。然而，5分钟和10分钟Apgar评分、产妇疾病和孕期产妇护理之间没有显著的相关性。结论:妊娠期糖尿病与并发症发生率升高有关，必须通过预防和疾病控制来降低并发症发生率，促进孕产妇和新生儿健康。
{"title":"Comparison of Pregnancy Outcomes in Diabetic and Healthy Women","authors":"M. Jafari, Hadis Fattahi, Leila Sheikhy, Sodabeh Eskandari, M. Mirzaei-Alavijeh","doi":"10.5812/jhrt-119317","DOIUrl":"https://doi.org/10.5812/jhrt-119317","url":null,"abstract":"Background: Gestational diabetes is the most prevalent metabolic disorder during pregnancy. Therefore, it is essential to recognize its outcomes and complications. Objectives: The present study aimed to compare pregnancy outcomes in diabetic and healthy women. Methods: This case-control study was conducted on 380 diabetic and healthy women, who were divided into two groups of 190, at Moatazedi Hospital in Kermanshah, Iran in 2019. The participants were selected via convenience sampling. Data were collected using a researcher-made checklist designed based on the family records of the participants. Data analysis was performed in SPSS version 22 using chi-square, Fisher’s exact test, and the Mann-Whitney U test. Results: A significant correlation was observed between gestational age, maternal body mass index, birth weight, infant’s height, mode of delivery (P < 0.01), preeclampsia (P = 0.01), and the family history of diabetes (P = 0.03) in the diabetic and healthy pregnant women. However, no significant correlation was denoted between the five- and 10-minute Apgar scores, maternal disorders, and maternal care during pregnancy. Conclusions: According to the results, gestational diabetes is associated with an increase rate of complications, which must be diminished through prevention and disease control to promote maternal and neonatal health.","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134279448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to \"The Effect of 12 Weeks of Intense Interval Training on Changes in Adipose Levels and Visceral Adiposity Index in Women with Polycystic Ovary Syndrome\"","authors":"Bahar Faryadian, N. Behpoor, V. Tadibi","doi":"10.5812/jhrt-127663","DOIUrl":"https://doi.org/10.5812/jhrt-127663","url":null,"abstract":"<jats:p />","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125872919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Soroush, H. Abdollahzad, S. Vaziri, S. Bazargan, Nadya Baharirad
: Nowadays, the world is experiencing the COVID-19 pandemic. Iron deficiency anemia and vitamin D deficiency are two of the world's most prevalent health problems. Severe COVID-19 patients were found with elevated serum ferritin and decreased vitamin D levels. There is a need to investigate the possible roles of micronutrients in the severity and mortality of COVID-19. This descriptive-analytical cross-sectional study was conducted on 437 COVID-19 patients who were hospitalized from April to August 2020. Demographic, clinical, and laboratory data of the patients were collected. Medical experts determined the severity of the infection based on the severity of the clinical symptoms and the extent and degree of the lung infection. The data were analyzed using SPSS statistical software Version 16. The mean age of the participants was 60.74 ± 16.70 years old, and the most common comorbidities were diabetes type II (15.1%) and hypertension (12%). Shortness of breath (58.6%), anosmia (55.1%), and ageusia (45.1%) were the most common presenting symptoms. The mean serum vitamin D level was 28.86 ± 15.69 ng/mL, and vitamin D deficiency was found in 53% of patients. The mean serum ferritin level was 125.32 ± 97.99 for males and 302 ± 73.6 for females. Significant correlations were observed between serum vitamin D levels, lower oxygen saturation rate, and COVID–19 severity. A significant relationship was found between the serum ferritin levels and hospitalization duration (P < 0.05). Our findings indicated that COVID-19 patients treated in the hospital had a high prevalence of hypovitaminosis D. The severity of the disease was increased in patients with vitamin D deficiency and elevated serum ferritin levels.
{"title":"Correlation of Serum Ferritin, Vitamin D Levels, and Severity of Clinical Symptoms in Patients with COVID-19","authors":"A. Soroush, H. Abdollahzad, S. Vaziri, S. Bazargan, Nadya Baharirad","doi":"10.5812/ijhls-121083","DOIUrl":"https://doi.org/10.5812/ijhls-121083","url":null,"abstract":": Nowadays, the world is experiencing the COVID-19 pandemic. Iron deficiency anemia and vitamin D deficiency are two of the world's most prevalent health problems. Severe COVID-19 patients were found with elevated serum ferritin and decreased vitamin D levels. There is a need to investigate the possible roles of micronutrients in the severity and mortality of COVID-19. This descriptive-analytical cross-sectional study was conducted on 437 COVID-19 patients who were hospitalized from April to August 2020. Demographic, clinical, and laboratory data of the patients were collected. Medical experts determined the severity of the infection based on the severity of the clinical symptoms and the extent and degree of the lung infection. The data were analyzed using SPSS statistical software Version 16. The mean age of the participants was 60.74 ± 16.70 years old, and the most common comorbidities were diabetes type II (15.1%) and hypertension (12%). Shortness of breath (58.6%), anosmia (55.1%), and ageusia (45.1%) were the most common presenting symptoms. The mean serum vitamin D level was 28.86 ± 15.69 ng/mL, and vitamin D deficiency was found in 53% of patients. The mean serum ferritin level was 125.32 ± 97.99 for males and 302 ± 73.6 for females. Significant correlations were observed between serum vitamin D levels, lower oxygen saturation rate, and COVID–19 severity. A significant relationship was found between the serum ferritin levels and hospitalization duration (P < 0.05). Our findings indicated that COVID-19 patients treated in the hospital had a high prevalence of hypovitaminosis D. The severity of the disease was increased in patients with vitamin D deficiency and elevated serum ferritin levels.","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132543969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Individuals with alexithymia have a limited ability to adapt to stressful situations, leading to high levels of psychological distress, anxiety, and stress symptoms. Objectives: This study aimed to investigate the role of insecure attachment in psychological distress within Islamic Azad Universities of Tehran in 2020 by mediating alexithymia. Methods: The structural equation modeling (SEM) was used as the primary research method in this study. The study population included all university students between 20- and 40-years old studying at the Islamic Azad Universities of Tehran in the 2019 - 20 academic year. A total of 305 students was selected as samples using the multi-stage cluster sampling method. Several research tools were used, including the Depression Anxiety Stress Scale, the Experiences in Close Relationships-Revised (ECR-R), and the Toronto Alexithymia Scale (TAS-20). The data were analyzed using a correlation matrix in SPSS statistical software Version 24 and structural equation modeling (SEM) in Amos-26. Results: The results indicated that the insecure attachment style had a direst positive effect on the states of psychological distress (anxiety, stress, and depression) (P < 0.001). Alexithymia also played a mediating role in insecure attachment affecting psychological distress (P < 0.001). Conclusions: Results revealed in the correlation between insecure attachment and states of psychological distress mediated by the alexithymia. Given the importance of attachment style and alexithymia in the development of anxiety, stress, and depression, therapists are recommended to take these variables into account.
{"title":"A Model for Psychological Distress Based on Insecure Attachment Mediated by Alexithymia in Students at Islamic Azad Universities in Tehran","authors":"M. Mahmoudi, H. Saberi, S. Bashardoust","doi":"10.5812/ijhls-122195","DOIUrl":"https://doi.org/10.5812/ijhls-122195","url":null,"abstract":"Background: Individuals with alexithymia have a limited ability to adapt to stressful situations, leading to high levels of psychological distress, anxiety, and stress symptoms. Objectives: This study aimed to investigate the role of insecure attachment in psychological distress within Islamic Azad Universities of Tehran in 2020 by mediating alexithymia. Methods: The structural equation modeling (SEM) was used as the primary research method in this study. The study population included all university students between 20- and 40-years old studying at the Islamic Azad Universities of Tehran in the 2019 - 20 academic year. A total of 305 students was selected as samples using the multi-stage cluster sampling method. Several research tools were used, including the Depression Anxiety Stress Scale, the Experiences in Close Relationships-Revised (ECR-R), and the Toronto Alexithymia Scale (TAS-20). The data were analyzed using a correlation matrix in SPSS statistical software Version 24 and structural equation modeling (SEM) in Amos-26. Results: The results indicated that the insecure attachment style had a direst positive effect on the states of psychological distress (anxiety, stress, and depression) (P < 0.001). Alexithymia also played a mediating role in insecure attachment affecting psychological distress (P < 0.001). Conclusions: Results revealed in the correlation between insecure attachment and states of psychological distress mediated by the alexithymia. Given the importance of attachment style and alexithymia in the development of anxiety, stress, and depression, therapists are recommended to take these variables into account.","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121531575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mirzaei-Alavijeh, C. Jalili, Shohreh Farshid, Nafiseh Mirzaei-Alavijeh, Farnoosh Babakhani, F. Jalilian
Background: Academic cynicism means feeling tired because of demands and being pessimistic and unwilling about the texts and assignments. Objectives: The present study aimed to determine the correlation among academic cynicism and academic variables among Kermanshah University of Medical Sciences (KUMS) students. Methods: This cross-sectional study was conducted among 288 KUMS students in 2018, who were collected using simple random sampling method proportional to the selected sample size. The data were collected by a self-administered questionnaire and analyzed by nonparametric methods using SPSS Version 16. Results: The mean score of academic cynicism was as much as 11.48 ± 3.50, indicating that the participants obtained 57.4% of the maximum score of academic cynicism. According to results, there was a significant and inverse correlation among academic cynicism and academic achievement (r = -0.195). The mean rank of academic cynicism was significantly higher among MD students (P = 0.001) and dentistry (P = 0.008). Conclusions: Students received more than half of the possible score for academic cynicism, which was significant and inversely affected academic achievement. Therefore, developing, implementing, and evaluating interventions are essential to prevent and reduce academic cynicism among students.
{"title":"What Is the Status of Academic Cynicism and Its Relationship with Academic Variables Among Kermanshah University of Medical Sciences Students?","authors":"M. Mirzaei-Alavijeh, C. Jalili, Shohreh Farshid, Nafiseh Mirzaei-Alavijeh, Farnoosh Babakhani, F. Jalilian","doi":"10.5812/ijhls-122873","DOIUrl":"https://doi.org/10.5812/ijhls-122873","url":null,"abstract":"Background: Academic cynicism means feeling tired because of demands and being pessimistic and unwilling about the texts and assignments. Objectives: The present study aimed to determine the correlation among academic cynicism and academic variables among Kermanshah University of Medical Sciences (KUMS) students. Methods: This cross-sectional study was conducted among 288 KUMS students in 2018, who were collected using simple random sampling method proportional to the selected sample size. The data were collected by a self-administered questionnaire and analyzed by nonparametric methods using SPSS Version 16. Results: The mean score of academic cynicism was as much as 11.48 ± 3.50, indicating that the participants obtained 57.4% of the maximum score of academic cynicism. According to results, there was a significant and inverse correlation among academic cynicism and academic achievement (r = -0.195). The mean rank of academic cynicism was significantly higher among MD students (P = 0.001) and dentistry (P = 0.008). Conclusions: Students received more than half of the possible score for academic cynicism, which was significant and inversely affected academic achievement. Therefore, developing, implementing, and evaluating interventions are essential to prevent and reduce academic cynicism among students.","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123706516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Ahadinezhad, Omid Khosravizadeh, Aisa Maleki, E. Ghanbari
Context: One of the most important income sources of hospitals is the payment of insurance organizations, part of which is not paid as deductions in Iran. Studies have reported different values for insurance deductions, proposing various reasons. Objectives: The present study aimed to provide the published evidence of these deductions and their causes over the past 13 years. Data Sources: This systematic review and meta-analysis was conducted in 2021. Data were collected via searching in databases such as Google Scholar, Scopus, PubMed, Web of Science, SID, Magiran, and Irandoc until August 2021 using keywords such as “deduction”, “medical deduction”, “hospital”, “medical center”, and “Iran”. Data Extraction: To calculate the pooled values of hospital deductions, a random-effects meta-analysis was performed in the Stata software version 15 at 95% confidence interval. In addition, the possible heterogeneity of the studies was evaluated using the I2 statistic, and a forest plot was also used to report the results. Publication bias was assessed using a funnel plot. Results: In total, 16 articles were included in the meta-analysis. The pooled percentage of deductions (PPCD) based on random effects was 5% (95% CI: 2.88 - 7.124), and the hypothesis was rejected (PPCD = 0; Z = 31.26; P = 0.000). Based on the random-effects method, the pooled prevalence of deductions was 45.21% (95% CI: 17.601 - 72.824). Moreover, the pooled prevalence of deductions (PPVD) was considered statistically significant (PPVD = 0; Z = 251.16; P = 0.000). The variation in ES attributable to heterogeneity (I2) was estimated at 99.6%, and documentation problems were considered the most common cause of deductions (17.96%). Conclusions: According to the results, the prevalence of deductions in Iranian public hospitals is significant, and the share of deductions from the bill claimed by the hospital is manageable, albeit small.
{"title":"Rate and Causes of Claim Denials in Iranian Hospitals: A Systematic Review and Meta-analysis","authors":"B. Ahadinezhad, Omid Khosravizadeh, Aisa Maleki, E. Ghanbari","doi":"10.5812/ijhls-121200","DOIUrl":"https://doi.org/10.5812/ijhls-121200","url":null,"abstract":"Context: One of the most important income sources of hospitals is the payment of insurance organizations, part of which is not paid as deductions in Iran. Studies have reported different values for insurance deductions, proposing various reasons. Objectives: The present study aimed to provide the published evidence of these deductions and their causes over the past 13 years. Data Sources: This systematic review and meta-analysis was conducted in 2021. Data were collected via searching in databases such as Google Scholar, Scopus, PubMed, Web of Science, SID, Magiran, and Irandoc until August 2021 using keywords such as “deduction”, “medical deduction”, “hospital”, “medical center”, and “Iran”. Data Extraction: To calculate the pooled values of hospital deductions, a random-effects meta-analysis was performed in the Stata software version 15 at 95% confidence interval. In addition, the possible heterogeneity of the studies was evaluated using the I2 statistic, and a forest plot was also used to report the results. Publication bias was assessed using a funnel plot. Results: In total, 16 articles were included in the meta-analysis. The pooled percentage of deductions (PPCD) based on random effects was 5% (95% CI: 2.88 - 7.124), and the hypothesis was rejected (PPCD = 0; Z = 31.26; P = 0.000). Based on the random-effects method, the pooled prevalence of deductions was 45.21% (95% CI: 17.601 - 72.824). Moreover, the pooled prevalence of deductions (PPVD) was considered statistically significant (PPVD = 0; Z = 251.16; P = 0.000). The variation in ES attributable to heterogeneity (I2) was estimated at 99.6%, and documentation problems were considered the most common cause of deductions (17.96%). Conclusions: According to the results, the prevalence of deductions in Iranian public hospitals is significant, and the share of deductions from the bill claimed by the hospital is manageable, albeit small.","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121798236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyedeh Sara Moosavi, M. Madani, Sako Mirzaie, N. Hosseini Jazani
Background: Mutations in bacteria frequently occur that display a crucial need for new antimicrobial agents. Metallo-β-lactamases (MBLs) are a growing threat to maintaining the effectiveness of beta-lactam antibiotics. Resistance to beta-lactam antibiotics is one of the most common types of antibiotic resistance, which causes the ineffectiveness of antibiotics. Objectives: This study aimed to identify a novel inhibitor using molecular dynamics simulations to inhibit VIM-2 Metallo-β-lactamases and overcome carbapenem resistance in Pseudomonas aeruginosa strains. Methods: Computational biology tools were employed for this study, including molecular dynamics, binding free energy, virtual screening, and docking. Natural compounds were taken from the ZINC databank and prepared. At the next stage, the prepared compounds were screened based on docking energy in the active site of VIM-2 MBL by Schrödinger (Maestro) software, and better compounds were selected. Captopril was chosen as a positive control inhibitor for VIM-2 MBLs. Ultimately, molecular dynamics simulations were performed using GROMACS software, and outputs were analyzed. Results: Maestro software's screening results showed that ZINC00517765 was the best inhibitor with -12.29 kcal mol-1 docking energy. The ADME investigations revealed that ZINC00517765 had an appropriate range of pharmacokinetics, lipophilicity, and drug-likeness features as an inhibitor of VIM-2 MBL. Molecular dynamics outcomes explicated that VIM-2 MBL in the presence of ZINC00517765 had better stability during simulation. The results of the MM-PBSA study illustrated that ZINC00517765 with -72.29 kJ mol-1 binding free energy was more potent than Captopril with -23.39 kJ mol-1. Conclusions: This study showed that VIM-2 MBL in the presence of ZINC00517765 has suitable stability during simulation. Also, more hydrogen bonds and stronger binding free energy than Captopril confirm that ZINC00517765 is a proper candidate for further studies and laboratory investigation.
{"title":"Discovery of a Potent Inhibitor to Overcome Carbapenem Resistance in Pseudomonas aeruginosa Strains via Inhibition of VIM-2 Metallo-β-lactamases","authors":"Seyedeh Sara Moosavi, M. Madani, Sako Mirzaie, N. Hosseini Jazani","doi":"10.5812/ijhls.121109","DOIUrl":"https://doi.org/10.5812/ijhls.121109","url":null,"abstract":"Background: Mutations in bacteria frequently occur that display a crucial need for new antimicrobial agents. Metallo-β-lactamases (MBLs) are a growing threat to maintaining the effectiveness of beta-lactam antibiotics. Resistance to beta-lactam antibiotics is one of the most common types of antibiotic resistance, which causes the ineffectiveness of antibiotics. Objectives: This study aimed to identify a novel inhibitor using molecular dynamics simulations to inhibit VIM-2 Metallo-β-lactamases and overcome carbapenem resistance in Pseudomonas aeruginosa strains. Methods: Computational biology tools were employed for this study, including molecular dynamics, binding free energy, virtual screening, and docking. Natural compounds were taken from the ZINC databank and prepared. At the next stage, the prepared compounds were screened based on docking energy in the active site of VIM-2 MBL by Schrödinger (Maestro) software, and better compounds were selected. Captopril was chosen as a positive control inhibitor for VIM-2 MBLs. Ultimately, molecular dynamics simulations were performed using GROMACS software, and outputs were analyzed. Results: Maestro software's screening results showed that ZINC00517765 was the best inhibitor with -12.29 kcal mol-1 docking energy. The ADME investigations revealed that ZINC00517765 had an appropriate range of pharmacokinetics, lipophilicity, and drug-likeness features as an inhibitor of VIM-2 MBL. Molecular dynamics outcomes explicated that VIM-2 MBL in the presence of ZINC00517765 had better stability during simulation. The results of the MM-PBSA study illustrated that ZINC00517765 with -72.29 kJ mol-1 binding free energy was more potent than Captopril with -23.39 kJ mol-1. Conclusions: This study showed that VIM-2 MBL in the presence of ZINC00517765 has suitable stability during simulation. Also, more hydrogen bonds and stronger binding free energy than Captopril confirm that ZINC00517765 is a proper candidate for further studies and laboratory investigation.","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115041580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omid Khosravizadeh, B. Ahadinezhad, S. Shahsavari, Maryam Ghiasvand, M. Mehri
Background: Performance is the primary concern of every organizational manager, and achieving higher performance is a significant goal of every organization. Organizational silence may adversely affect organizational performance. Healthcare centers should pay special attention to this issue due to their different job descriptions and environments compared to other sectors. Objectives: The present study aimed to investigate the effect of organizational silence and its dimensions on the professional performance of health workers in the medical centers in Qazvin province, Iran in 2020. Methods: This was a descriptive-analytical study in terms of objective and a cross-sectional study in terms of design. The study was conducted in the medical centers affiliated to Qazvin University of Medical Sciences. In total, 365 questionnaires were distributed to select a sample of the healthcare workers from the selected centers in proportion to the total number of the staff. Data analysis was performed in SPSS version 22 using path analysis at the significance level of 0.05. Results: A significant, inverse (negative) correlation was observed between organizational silence and the professional performance of the staff (P < 0.05). Among various dimensions of organizational silence, the highest and lowest mean scores belonged to acquiescent silence (15.633 ± 4.291) and altruistic silence (12.180 ± 3.719), respectively. As for the dimensions of professional performance, the highest and lowest mean scores belonged to evaluation (29.675 ± 6.071) and help (15.087 ± 3.206), respectively. Conclusions: Based on the findings, it is recommended that the organizational atmosphere of the medical centers be improved so that the healthcare workers could provide feedback without concerns of being criticized by colleagues and superiors and the fear of consequences.
背景:绩效是每个组织管理者最关心的问题，实现更高的绩效是每个组织的重要目标。组织沉默可能对组织绩效产生负面影响。由于医疗保健中心的工作描述和环境与其他部门不同，因此应特别注意此问题。目的:本研究旨在调查组织沉默及其维度对2020年伊朗加兹温省医疗中心卫生工作者专业绩效的影响。方法:目的为描述性分析研究，设计为横断面研究。这项研究是在卡兹温医学科学大学附属的医学中心进行的。总共分发了365份问卷，以按工作人员总数的比例从选定的中心选择卫生保健工作者样本。数据分析采用SPSS version 22，采用通径分析，显著性水平为0.05。结果:组织沉默与员工职业绩效呈显著负相关(P < 0.05)。在组织沉默的各维度中，平均得分最高的是默认性沉默(15.633±4.291)分，最低的是利他性沉默(12.180±3.719)分。在专业绩效维度上，平均得分最高的为评价(29.675±6.071)分，最低的为帮助(15.087±3.206)分。结论:根据研究结果，建议改善医疗中心的组织氛围，使医护人员可以在不担心被同事和上级批评和害怕后果的情况下提供反馈。
{"title":"Role of Organizational Silence in the Professional Performance of Frontline Staff in the Hospital Structure: A Path Analysis","authors":"Omid Khosravizadeh, B. Ahadinezhad, S. Shahsavari, Maryam Ghiasvand, M. Mehri","doi":"10.5812/ijhls.121301","DOIUrl":"https://doi.org/10.5812/ijhls.121301","url":null,"abstract":"Background: Performance is the primary concern of every organizational manager, and achieving higher performance is a significant goal of every organization. Organizational silence may adversely affect organizational performance. Healthcare centers should pay special attention to this issue due to their different job descriptions and environments compared to other sectors. Objectives: The present study aimed to investigate the effect of organizational silence and its dimensions on the professional performance of health workers in the medical centers in Qazvin province, Iran in 2020. Methods: This was a descriptive-analytical study in terms of objective and a cross-sectional study in terms of design. The study was conducted in the medical centers affiliated to Qazvin University of Medical Sciences. In total, 365 questionnaires were distributed to select a sample of the healthcare workers from the selected centers in proportion to the total number of the staff. Data analysis was performed in SPSS version 22 using path analysis at the significance level of 0.05. Results: A significant, inverse (negative) correlation was observed between organizational silence and the professional performance of the staff (P < 0.05). Among various dimensions of organizational silence, the highest and lowest mean scores belonged to acquiescent silence (15.633 ± 4.291) and altruistic silence (12.180 ± 3.719), respectively. As for the dimensions of professional performance, the highest and lowest mean scores belonged to evaluation (29.675 ± 6.071) and help (15.087 ± 3.206), respectively. Conclusions: Based on the findings, it is recommended that the organizational atmosphere of the medical centers be improved so that the healthcare workers could provide feedback without concerns of being criticized by colleagues and superiors and the fear of consequences.","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133332653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Mosazadeh, Farshad Faezi Razi, Masoud Lajevardi, H. Mousazadeh, A. Ghorbani, Farahnaz Akbarzadeh Almani, Faranak Shiran
: The present study had a twofold objective, including the reconceptualization of medical tourists’ perceived risk in the COVID-19 pandemic and developing strategies to reduce medical tourists’ perceived risk during the pandemic. These two steps were referred to as a strategic-based approach. The first step defines medical tourists’ perceived risk as the subjective/cognitive (mind-driven) expectations and objective/actual (real-image driven) evaluation of the negative consequences/losses before/after making travel decisions to an unsafe COVID-19 destination. Following that, the associated dimensions were identified, such as psychological, financial, health, legal, performance, facility, and time risks. Finally, two main strategies (country-based and hospital-/clinic-based) were developed to create a safe COVID-19 destination. This study could make significant theoretical and practical contributions to strategic medical tourism management.
{"title":"Restarting Medical Tourism in the COVID-19 Pandemic: A Strategic-based Approach","authors":"H. Mosazadeh, Farshad Faezi Razi, Masoud Lajevardi, H. Mousazadeh, A. Ghorbani, Farahnaz Akbarzadeh Almani, Faranak Shiran","doi":"10.5812/ijhls.117932","DOIUrl":"https://doi.org/10.5812/ijhls.117932","url":null,"abstract":": The present study had a twofold objective, including the reconceptualization of medical tourists’ perceived risk in the COVID-19 pandemic and developing strategies to reduce medical tourists’ perceived risk during the pandemic. These two steps were referred to as a strategic-based approach. The first step defines medical tourists’ perceived risk as the subjective/cognitive (mind-driven) expectations and objective/actual (real-image driven) evaluation of the negative consequences/losses before/after making travel decisions to an unsafe COVID-19 destination. Following that, the associated dimensions were identified, such as psychological, financial, health, legal, performance, facility, and time risks. Finally, two main strategies (country-based and hospital-/clinic-based) were developed to create a safe COVID-19 destination. This study could make significant theoretical and practical contributions to strategic medical tourism management.","PeriodicalId":304466,"journal":{"name":"Journal of Health Reports and Technology","volume":"2 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123543911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：