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Custo-efetividade da radiocirurgia estereotáxica no tratamento de metástases cerebrais: revisão sistemática 立体定向放射手术治疗脑转移的成本-效果:系统综述
Pub Date : 2016-12-28 DOI: 10.25758/SET.1461
Leandro Luís
ABSTRACT: Introduction – Brain metastases are a problem due to the oncologic disease, which significantly limit patient survival and their quality of life. The stereotactic radiosurgery discloses a non-invasive removal of brain metastases. Objectives – Verify if stereotactic radiosurgery is more cost-effective than alternative treatments for brain metastases in cancer patients. Methods – We conducted a systematic review of literature using EBSCO host and PubMed between 2005 and 2015. The search terms were ‘radiosurgery’, ‘brain’, ‘metastasis’, ‘economics’, and ‘cost-benefit analysis’. The survey revealed 57 potentially eligible articles for the review, which were subject to an evaluation in accordance with the defined selection criteria. Three articles were included in the review. Results and Discussion – The review showed stereotactic radiosurgery dominance in relation to the two alternatives studied (total radiation of the brain and traditional surgery for resection of metastases). This superiority is associated with lower costs and equal or better effects (effectiveness or utility) of stereotactic radiosurgery. The cost of stereotacticradiosurgery seems to be the key differentiator relative to alternative treatments, lower than them in the three studies. Conclusion – The associated costs and effects of using stereotactic radiosurgery suggest that this will be the best option for a more rational treatment of patients with brain metastases. However, the findings are limited because of the scarcity of evaluated studies in the review.
摘要:导读-脑转移是肿瘤疾病的一个问题,它严重限制了患者的生存和生活质量。立体定向放射外科揭示了一种非侵入性脑转移瘤切除。目的:验证立体定向放射手术治疗脑转移癌患者是否比其他治疗方法更具成本效益。方法:我们对2005年至2015年间使用EBSCO主机和PubMed的文献进行了系统综述。搜索词是“放射外科”、“脑”、“转移”、“经济学”和“成本效益分析”。调查显示了57篇可能符合审查条件的文章,这些文章将根据确定的选择标准进行评估。三篇文章被纳入综述。结果和讨论-回顾显示立体定向放射手术在两种替代研究(脑全辐射和传统手术切除转移瘤)中占主导地位。这种优势与立体定向放射手术的低成本和相同或更好的效果(有效性或效用)有关。立体定向放射手术的成本似乎是与其他治疗方法相比的关键区别,在这三项研究中,立体定向放射手术的成本比其他治疗方法低。结论:使用立体定向放射手术的相关费用和效果表明,这将是更合理治疗脑转移患者的最佳选择。然而,由于本综述中评估研究的稀缺性,研究结果是有限的。
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引用次数: 1
Obesidade: regulação hormonal 肥胖:荷尔蒙调节
Pub Date : 2016-12-28 DOI: 10.25758/SET.1421
L. Veiga
A obesidade e considerada pela OMS um problema de saude publica, existindo mundialmente cerca 1,9 mil milhoes de pessoas com excesso de peso e destas, 600 milhoes sao obesas(1). Esta patologia representa um risco elevado para doencas cardiovasculares, diabetes, hipertensao e cancro(2). Na sua genese esta um desequilibrio entre a energia ingerida e a energia despendida. Este desequilibrio pode resultar de fatores psicologicos, ambientais, geneticos e metabolicos, indutores de perturbacoes do comportamento alimentar, como o aumento de ingestao alimentar ou de um estilo de vida sedentario. A regulacao do balanco energetico resulta de uma variedade de estimulos aferentes que sao processados no sistema nervoso central e respostas eferentes, reguladoras do apetite e saciedade. Os sinais aferentes podem ser transmitidos ao cerebro atraves do nervo vago ou pela via sistemica e envolver hormonas libertadas pelo tecido adiposo (leptina, adiponectina, resistina e visfatina) e pelo trato gastrointestinal (ghrelina, PYY, PP, GPL-1 e CCK). A resposta aos estimulos provoca ativacao ou inibicao de neuronios orexigenos (NPY, AgRP) e/ou anorexigenos (POMC, CART) localizados no hipotalamo. Enquanto a ativacao dos neuronios que expressam NPY e AgRP aumenta o apetite, a ativacao dos neuronios que expressam POMC ou CART origina saciedade(3). Muitos sao os estudos que procuraram compreender os mecanismos do balanco energetico. Contudo os resultados sao ainda, em alguns casos, pouco esclarecedores ou mesmo contraditorios. Com este artigo, pretende-se fazer uma revisao sobre os mecanismos de regulacao hormonal envolvidos na patogenese da obesidade, dando especial relevo as hormonas produzidas no tecido adiposo, estomago e intestino. Considerada uma epidemia do seculo XXI pela sua elevada prevalencia e complicacoes associadas, tornam-se cruciais mais estudos nesta area a fim de encontrar novas abordagens terapeuticas.
肥胖被世界卫生组织认为是一个公共健康问题,全世界大约有19亿人超重,其中6亿人肥胖(1)。这种病理是心血管疾病、糖尿病、高血压和癌症的高风险(2)。它的起源是摄入的能量和消耗的能量之间的不平衡。这种不平衡可能是由心理、环境、遗传和代谢因素引起的,这些因素会导致饮食行为紊乱,如增加食物摄入量或久坐不动的生活方式。能量平衡的调节是由中枢神经系统处理的各种传入刺激和调节食欲和饱腹感的传出反应产生的。传入信号可通过迷走神经或全身途径传递到大脑,涉及脂肪组织(瘦素、脂联素、抵抗素和visfatin)和胃肠道(ghrellin、PYY、PP、lpg -1和CCK)释放的激素。对刺激的反应触发或抑制位于下丘脑的orexigenic (NPY, AgRP)和/或异常exigenic (POMC, CART)神经元。激活表达NPY和AgRP的神经元会增加食欲,而激活表达POMC或CART的神经元会产生饱腹感(3)。有许多研究试图理解能量平衡的机制。然而,在某些情况下,结果仍然不是很有启发性,甚至是矛盾的。本文旨在回顾肥胖发病机制中的激素调节机制,特别强调脂肪组织、胃和肠道中产生的激素。由于其高流行率和相关并发症,被认为是21世纪的流行病,为了找到新的治疗方法,在这一领域的进一步研究变得至关重要。
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引用次数: 0
Efeito de um programa de exercícios para treino dos músculos do core e dos membros inferiores no equilíbrio em idosos residentes na comunidade 运动计划对社区老年居民核心和下肢肌肉平衡的影响
Pub Date : 2016-12-28 DOI: 10.25758/SET.1481
F. Faustino, Marta Brito, Marta Fernandes, Marta Gameiro, E. Carolino, Beatriz Fernandes
ABSTRACT: Objectives – To assess the effect of an exercise program targeting core muscles and lower limb muscles, in increasing balance in elderly living in the community. METHOD – Eleven subjects (10F; 1M), mean age 80±6.9 years old, independent and living in the community. The outcome measures included the Modified Clinical Test of Sensory Interaction on Balance (MCTSIB) performed on Balance Master® to measure balance; the Berg Balance Scale for fall risk; Falls Efficacy Scale for fear of falling; Sit-to-Stand 30 seconds for lower limb strength; Supine Bridge and Abdominal Stage Test for strength and endurance of core muscles and the 8-foot Up and Go Test for mobility. Results – There were statistical differences in Sit-to-Stand test, Supine Bridge test and MCTSIB Foam-Eyes Closed after the exercise program. Conclusion – An exercise program focused on training core and lower limb muscles did not show significant effects on balance in a sample of older adults living in the community, however it has increased lower limb strength and core muscles endurance.
摘要:目的:评估一项针对核心肌群和下肢肌肉的锻炼计划在提高社区老年人平衡能力方面的效果。方法:11名受试者(10F;1M),平均年龄80±6.9岁,独立生活在社区。结果测量包括在Balance Master®上进行的平衡感觉相互作用改良临床测试(MCTSIB)来测量平衡;用伯格平衡量表评估跌倒风险;跌倒恐惧效能量表;坐立30秒锻炼下肢力量;仰卧桥和腹部阶段测试的力量和耐力的核心肌肉和8英尺的上升和走测试的流动性。结果:运动后坐立测试、仰卧桥测试和MCTSIB泡沫闭眼测试均有统计学差异。结论:在社区老年人样本中,集中训练核心肌肉和下肢肌肉的锻炼计划对平衡没有显着影响,但它增加了下肢力量和核心肌肉耐力。
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引用次数: 0
O efeito do treino propriocetivo na prevenção de lesões da tibiotársica 本体运动训练对胫骨跗骨损伤预防的作用
Pub Date : 2016-12-28 DOI: 10.25758/SET.1511
A. Estorninho, Daniela Vinagre, R. Salvador, T. Nunes, V. Amaral, Nanci Sá, E. Carolino
ABSTRACT: Objectives – To evaluate and compare the efficacy of three different types of proprioceptive training in reducing the incidence of ankle sprains in male youth soccer players. Method – Muscle strength in tibiotarsal joint and proprioceptivity were evaluated and compared between three groups, with supervised proprioceptive training (GE), another unsupervised (GC1) and another with technical gesture training (GC2) over a nine week period, two to three times per week. Results – Both GE and GC1 showed significant increases (p<0.01) of proprioceptivity compared with GC2. Conclusion – The results suggest that after a short period of proprioceptive training, athletes improve their proprioceptivity but not necessarily tibiotarsal joint muscle strength. According to the study, supervision does not have an impact over training efficacy.
摘要:目的:评价和比较三种不同类型的本体感觉训练在减少青少年男性足球运动员踝关节扭伤发生率方面的效果。方法:在为期9周的时间内,评估并比较三组的胫跖关节肌肉力量和本体感觉,其中三组是有监督的本体感觉训练(GE),另一组是无监督的(GC1),另一组是技术手势训练(GC2),每周2 - 3次。结果-与GC2相比,GE和GC1的本体感受性均显著增加(p<0.01)。结论-结果表明,经过短时间的本体感觉训练,运动员的本体感觉得到改善,但不一定能提高胫跖关节肌肉力量。根据研究,监督对培训效果没有影响。
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引用次数: 1
O papel da literacia em saúde na decisão médica partilhada 卫生知识普及在共同医疗决策中的作用
Pub Date : 2016-12-28 DOI: 10.25758/SET.1501
A. Varela
ABSTRACT: Some studies have shown the relationship between an increased and more structured involvement of patients in clinical decision making, the improvement of literacy in health and the obtainment of health gains. However, the existence of misconceptions on the part of doctors and other health professionals may contribute to their low compliance regarding shared clinical decision and discussion of treatment options, particularly with users with low levels of literacy. With this critical essay, we intend to clarify these misconceptions, by doing an in depth reflection and analysis on communication’s key elements centered on the patient – health literacy and shared decision. Relevant issues about literacy in health and shared decision were presented, on which critical content was developed. This development is the most extensive part of the essay. We transmitted the point of view of several authors and a critical analysis, and we tried to illustrate these ideas with examples and research studies, thus validating the presented arguments and answering to questions raised during the analysis. Final considerations of this critical essay stress that promoting an increased user participation in clinical decision making improves the level of health literacy, through a patient-focused communication performed by qualified professionals taking into consideration social determinants, and health gains are obtained.
摘要:一些研究表明,患者在临床决策中的参与度和结构化程度的增加与健康素养的提高和健康收益的获得之间存在关系。然而,医生和其他保健专业人员存在误解,可能导致他们在共同临床决定和讨论治疗方案方面的依从性较低,特别是对文化水平较低的用户而言。通过这篇批判性的文章,我们打算澄清这些误解,通过对以患者健康素养和共同决策为中心的沟通关键要素进行深入的反思和分析。会议提出了有关卫生扫盲和共同决策的相关问题,并据此制定了重要内容。这个发展是这篇文章最广泛的部分。我们传递了几位作者的观点和批判性分析,我们试图用例子和研究来说明这些观点,从而验证所提出的论点,并回答分析过程中提出的问题。这篇批判性文章的最后考虑强调,促进用户更多地参与临床决策,通过合格的专业人员在考虑社会决定因素的情况下进行以患者为中心的沟通,提高卫生素养水平,并获得健康收益。
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引用次数: 0
Estudo comparativo da estereopsia com três testes diferentes: TNO®, Fly Stereo Acuity Test® e StereoTAB® em estudantes do ensino superior 三种不同测试:TNO®,Fly Stereo Acuity Test®和StereoTAB®在高等教育学生中的立体视比较研究
Pub Date : 2016-09-20 DOI: 10.25758/SET.1341
Ruben Morais, Ana Miguel, Denise Monteiro, Cleide Cassandra, I. Poças
ABSTRACT: Stereopsis is the perception of depth based on retinal disparity. Global stereopsis depends on the process of random dot stimuli and local stereopsis depends on contour perception. The aim of this study was to correlate three stereopsis tests: TNO ® , StereoTAB ® and Fly Stereo Acuity Test ® and to study the sensitivity and correlation between them, using TNO ® as the gold standard. Other variables as near convergence point, vergences, symptoms and optical correction were correlated with the three tests. Forty-nine students from Escola Superior de Tecnologia da Saude de Lisboa (ESTeSL), aged 18-26 years old were included. The stereopsis mean (standard-deviation-SD) values in each test were: TNO ® = 87.04’’ ±84.09’’; FlyTest ® = 38.18’’ ±34.59’’; StereoTAB ® = 124.89’’ ±137.38’’. About the coefficient of determination: TNO ® and StereoTAB ® with R 2 =0.6e TNO ® and FlyTest ® with R 2 =0.2. Pearson correlation coefficient shows a positive correlation between TNO ® and StereoTAB ® ( r =0.784 with α=0.01). Phi coefficient shows a strong and positive association between TNO ® and StereoTAB ® (Φ=0.848 with α=0.01). In the ROC Curve, the StereoTAB ® has an area under the curve bigger than the FlyTest ® with a sensivity of 92.3% for 94.4% of specificity, so it means that the test is sensitive with a good discriminative power.
立体视觉是基于视网膜视差的深度感知。全局立体视依赖于随机点刺激过程,局部立体视依赖于轮廓感知。本研究的目的是将三种立体视觉测试:TNO®、StereoTAB®和Fly Stereo Acuity Test®相关联,并以TNO®为金标准,研究它们之间的灵敏度和相关性。其他变量如近会聚点、会聚、症状和光学校正与三个测试相关。49名来自里斯本高等理工学院(ESTeSL)的学生,年龄18-26岁。各试验立体视觉均值(标准差- sd)值为:TNO®= 87.04±84.09;FlyTest®= 38.18 "±34.59 ";StereoTAB®= 124.89 "±137.38 "。关于决定系数:TNO®和StereoTAB®r2 =0.6; TNO®和FlyTest®r2 =0.2。Pearson相关系数显示TNO®与StereoTAB®呈正相关(r =0.784, α=0.01)。Phi系数显示TNO®与StereoTAB®呈正相关(Φ=0.848, α=0.01)。在ROC曲线上,StereoTAB®的曲线下面积大于FlyTest®,灵敏度为92.3%,特异度为94.4%,说明该试验灵敏度高,具有良好的判别能力。
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引用次数: 0
Dosimetria in vivo em tumores de mama: comparação entre a dose medida e calculada 乳腺肿瘤体内剂量测定:测量剂量与计算剂量的比较
Pub Date : 2016-09-20 DOI: 10.25758/SET.1371
A. Roma, Inês Ruas, R. Rocha, V. Gonçalves, A. Sá, Cátia Águas, Emmanuel Bonnarens, C. Coelho, Fátima Monsanto, E. Carolino
Introduction – In vivo dosimetry is useful in measuring the dose administered to patients during treatment, assessing significant differences between the prescribed dose and the dose to the target volume and the organs at risk. Purpose – To compare the measured dose with the calculated dose in patients with breast tumours with and without physical wedge. Methods – Entrance dose measurements using p-type diodes were performed for tangential fields and relative field-in-field in all 38 patients. Results – Statistically significant differences in open tangential fields ( ρ =0.000) were verified. Discussion – Studies report significant systematic deviations between planned and measured dose. Conclusion – With this study we conclude that there is no influence in the doses due to the presence of the physical wedge.
体内剂量法可用于测量治疗期间给予患者的剂量,评估处方剂量与靶体积和危险器官的剂量之间的显着差异。目的:比较具有和不具有物理楔形的乳腺肿瘤患者的测量剂量与计算剂量。方法:采用p型二极管对38例患者进行切向场和相对场对场的入口剂量测量。结果-证实了开切场的统计学显著差异(ρ =0.000)。讨论-研究报告计划剂量和测量剂量之间存在显著的系统性偏差。结论-通过这项研究,我们得出结论,由于物理楔的存在,对剂量没有影响。
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引用次数: 0
Comunicação médico-doente e consentimento informado em Portugal 葡萄牙的医患沟通和知情同意
Pub Date : 2016-09-20 DOI: 10.25758/SET.1381
A. Varela, Ezequiel Pinto, Manuel Carrageta
Introduction – The informed consent (IC) for performing medical procedures is influenced by communication between the doctor and the patient, although the impact of some of the communication determinants between these actors is unknown. Purpose – To identify and analyse those determinants influencing the ethical duty to inform in order to obtain an informed consent. Methods – The search for original research papers written in Portugal, between January 2005 and March 2015, involved Scholar Google, PubMed, B-ON and the Portuguese Scientific Open Access Repository electronic databases, by using the keywords ‘ consentimento informado ’, ‘ medico ’ and ‘ doente ’ ou ‘ informed consent ’, ‘ doctor ’ and ‘ patient ’. Results – Five papers meeting the inclusion criteria were identified and communication determinants in the doctor-patient relationship were found to influence the free and clear IC. Conclusion – The knowledge of the importance of these communicational determinants influencing the IC can help the doctor-patient interaction and the development of measures to improve the healthcare performance.
导言-实施医疗程序的知情同意受到医生和病人之间沟通的影响,尽管这些行为者之间的一些沟通决定因素的影响是未知的。目的-确定和分析影响告知道德义务的决定因素,以获得知情同意。方法:通过关键词“consent to informado”、“medico”和“doente”、“informed consent”、“doctor”和“patient”,检索2005年1月至2015年3月期间在葡萄牙撰写的原始研究论文,涉及Scholar b谷歌、PubMed、B-ON和葡萄牙科学开放存取库电子数据库。结果-确定了五篇符合纳入标准的论文,并发现医患关系中的沟通决定因素影响了自由和清晰的IC。结论-了解这些影响IC的沟通决定因素的重要性可以帮助医患互动和制定改善医疗绩效的措施。
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引用次数: 0
Qualidade de imagem em mamografia: apresentação do músculo grande peitoral na incidência oblíqua médio-lateral 乳房x线照相术的图像质量:中外侧斜入影时胸大肌的表现
Pub Date : 2016-09-20 DOI: 10.25758/SET.1361
J. Mota, S. R. Ventura
ABSTRACT: The mammography technique is, currently, the most reliable imaging method for the diagnoses of breast cancer, and for this reason it is essential the production of mammograms with high quality and consistency. Considering that the goal of mammography is to maximize the visualization of breast tissue, the aim of this work is to explore the presentation of the pectoral major muscle in the mammographic image.  We intended to assess the relationship between the technical procedures of the image acquisition and the presentation of the muscle, according to the current mammography quality criteria. The mammograms were collected from two reference hospitals in Porto, and thereafter, the image processing and statistics analysis was performed to assess qualitative and quantitative indicators of the image quality. In general, analyzing both clinical institution and based on these indicators, the hospital that uses a fixed angulation of the potter-bucky apart the patient's body habitus presented better results. This indicates that the existence of failures due to positioning errors is smaller when compared to the quality standard assessed. It was found, therefore, that the angulation of the potter-bucky device has a relevant and statistical significance on the quality of the mammographic images produced.
摘要:乳房x线摄影技术是目前诊断乳腺癌最可靠的成像方法,因此制作高质量和一致性的乳房x线照片至关重要。考虑到乳房x线摄影的目标是最大限度地显示乳房组织,本研究的目的是探讨乳房大肌在乳房x线摄影图像中的表现。我们打算根据目前的乳房x线摄影质量标准,评估图像采集技术程序与肌肉表现之间的关系。从波尔图的两家参考医院收集乳房x线照片,然后进行图像处理和统计分析,以评估图像质量的定性和定量指标。总的来说,通过对临床机构和这些指标的分析,医院采用固定角度的陶罐分开患者的身体习惯效果更好。这表明,与所评估的质量标准相比,定位误差导致的故障的存在较小。因此,我们发现,波特-巴基装置的角度对乳房x线摄影图像的质量具有相关的统计意义。
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引用次数: 1
Influência da escala de cores na avaliação qualitativa das imagens de cintigrafia de perfusão do miocárdio 颜色尺度对心肌灌注闪烁图像定性评价的影响
Pub Date : 2016-05-01 DOI: 10.25758/SET.1391
A. Figueiredo, E. Ramos, E. Carolino, Tânia Vaz, L. Vieira
Introduction – Myocardial perfusion imaging (MPI) is a widely accepted study applied in the diagnosis and follow-up of coronary artery disease. Interpretation of myocardial perfusion images requires visual analysis of the reconstructed slices. The color scale selected can have a significant effect on the final appearance of the image and on the clinical interpretation of myocardial perfusion. Aim – Evaluate the influence of the color scale in the qualitative analysis of MPI and study which one should be preferably used for visual interpretation of myocardial perfusion. Methods – Thirty five MPI studies were visually interpreted by 16 nuclear medicine technologist students in the following color scales: Cool , Gray , Gray Invert , Thermal and Warm . Visual analysis of Cool ’s color scale relied on a semi-quantitative scoring system. The remaining color scales were evaluated by comparison with Cool . Results/Discussion – For Cool ’s color scale, inter-operator variability has shown statistically significant differences among all the participants ( p <0.05), which can be assigned to the subjectivity of the visual evaluation. The results obtained for Gray and Gray Invert colors scales were the closest for the myocardial perfusion observed with Cool , being alternative color scales suited for this purpose. Regarding Thermal and Warm color scales the results were divergent, showing that they are not the optimal choice for myocardial perfusion interpretation. Conclusion – The color scale selected can influence the qualitative assessment of MPI
心肌灌注成像(MPI)在冠状动脉疾病的诊断和随访中应用广泛。心肌灌注图像的解释需要对重建的切片进行视觉分析。所选择的色阶对图像的最终外观和心肌灌注的临床解释有重要影响。目的:评价MPI色标度在定性分析中的影响,探讨哪一种色标度更适合用于心肌灌注的视觉解释。方法:由16名核医学技术专业的学生对35份MPI研究进行了视觉解读,颜色分为:冷色、灰色、反灰色、暖色和暖色。对Cool色标的视觉分析依赖于半定量评分系统。通过与Cool进行比较来评估剩余的色阶。结果/讨论-对于Cool ' s色标,操作者之间的可变性在所有参与者之间显示出统计学上显著的差异(p <0.05),这可以归因于视觉评价的主观性。Gray和Gray Invert色标得到的结果与Cool观察到的心肌灌注最接近,是适合于这一目的的可选色标。对于热色和暖色标度,结果是不同的,表明它们不是心肌灌注解释的最佳选择。结论-色阶的选择影响MPI的定性评价
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引用次数: 1
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Saude Tecnologia
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