Pub Date : 2024-07-01DOI: 10.1097/gh9.0000000000000461
Aleena Aftab, Tooba Hussain, Rameez Hussain, H. H. Shah, Ume Habiba, Md Ariful Haque
{"title":"Statins in breast cancer treatment and management: a mini-review of potential benefits and clinical implications","authors":"Aleena Aftab, Tooba Hussain, Rameez Hussain, H. H. Shah, Ume Habiba, Md Ariful Haque","doi":"10.1097/gh9.0000000000000461","DOIUrl":"https://doi.org/10.1097/gh9.0000000000000461","url":null,"abstract":"","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":"43 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1097/gh9.0000000000000463
Yara Hodaifa, Raghad Tarcha, F. Alghawe, Sana Btrush, Wafaa Batha, Maysoun Kudsi
Behçet’s disease is a rare systemic condition, with the mean age of patients being ~30 years. It affects men more than women. Behçet’s disease should be considered in any patient with a systemic inflammatory disease characterized by recurrent orogenital ulcers and uveitis. Fournier’s gangrene is a rare life-threatening bacterial genital infection that acquires at any age with male predominance. A healthy 32-year-old male presented with fatigue, fever, oral ulcers, and discrete scrotal ulcers. He had Fournier’s gangrene and a new diagnosis of Behçet’s disease. He was treated with intravenous antibiotics with surgical debridement. Before discharge, the patient was commenced on 1 mg/day of colchicine. During the follow-up visits, we noted small ulcerations without necrosis on the scrotum, which we started with oral prednisolone and oral methotrexate. He remains under their care 6 months later. The patient had recurrent oral ulcerations followed by genital aphthous ulceration and acneiform eruptions that met Behçet’s diagnosing criteria. Fournier’s gangrene on the scrotum was diagnosed due to the physical examination, radiological findings, and histological findings. A PubMed search reveals one similar case report. This patient’s only risk factor for Bechet’s was his ethnicity and male gender for Fournier’s gangrene. The young adult patient presented unusually, with a diagnosis of Fournier’s gangrene superimposed on undiagnosed Behçet’s disease. An understanding of the epidemiology and risk factors can help in the diagnosis of these rare pathologies.
{"title":"Undiagnosed Behçet’s disease presenting as Fournier’s gangrene in undiagnosed Behçet’s disease: a case report of a young adult male","authors":"Yara Hodaifa, Raghad Tarcha, F. Alghawe, Sana Btrush, Wafaa Batha, Maysoun Kudsi","doi":"10.1097/gh9.0000000000000463","DOIUrl":"https://doi.org/10.1097/gh9.0000000000000463","url":null,"abstract":"\u0000 \u0000 Behçet’s disease is a rare systemic condition, with the mean age of patients being ~30 years. It affects men more than women. Behçet’s disease should be considered in any patient with a systemic inflammatory disease characterized by recurrent orogenital ulcers and uveitis. Fournier’s gangrene is a rare life-threatening bacterial genital infection that acquires at any age with male predominance.\u0000 \u0000 \u0000 \u0000 A healthy 32-year-old male presented with fatigue, fever, oral ulcers, and discrete scrotal ulcers. He had Fournier’s gangrene and a new diagnosis of Behçet’s disease. He was treated with intravenous antibiotics with surgical debridement. Before discharge, the patient was commenced on 1 mg/day of colchicine. During the follow-up visits, we noted small ulcerations without necrosis on the scrotum, which we started with oral prednisolone and oral methotrexate. He remains under their care 6 months later.\u0000 \u0000 \u0000 \u0000 The patient had recurrent oral ulcerations followed by genital aphthous ulceration and acneiform eruptions that met Behçet’s diagnosing criteria. Fournier’s gangrene on the scrotum was diagnosed due to the physical examination, radiological findings, and histological findings. A PubMed search reveals one similar case report. This patient’s only risk factor for Bechet’s was his ethnicity and male gender for Fournier’s gangrene.\u0000 \u0000 \u0000 \u0000 The young adult patient presented unusually, with a diagnosis of Fournier’s gangrene superimposed on undiagnosed Behçet’s disease. An understanding of the epidemiology and risk factors can help in the diagnosis of these rare pathologies.\u0000","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1097/gh9.0000000000000462
Sumaya Dumirieh, Leen Al lahham, Raghad Tarcha, Ghofran Hoha, Suaad Hamsho, Maysoun Kudsi
The COVID-19 pandemic has led to a post-acute syndrome that can persist for a prolonged period. The authors’ case reported a 31-years-old male presented with the sensation of sand in his eyes and a dry mouth for 3 months after infection with COVID-19 confirmed by nasopharyngeal swab 3 months ago. Laboratory tests including immunological profile were normal. Schirmer’s test was positive. He was treated with artificial tears with corticosteroid drops and water drinking. Within 15 days he noticed an improvement in his sicca symptoms. The post-acute COVID-19 syndrome can persist for a longer duration than expected, even after the acute onset of the disease. Some patients may experience ocular and oral symptoms such as dry mouth, dysgeusia, and dry eye diseases. The pathophysiology of these symptoms may be related to viral pathophysiologic changes, immunologic aberrations, and inflammatory reactions that destroy the tissue of salivary glands. Additionally, there is evidence of elevated autoantibodies in post-COVID-19 patients. Future studies are needed to understand the sequela of this infection. What makes this case special is the combination of dry eyes and dry mouth with a negative immunological profile in a young patient who had COVID without severe symptoms.
{"title":"Sicca syndrome post-COVID-19 infection: a case report","authors":"Sumaya Dumirieh, Leen Al lahham, Raghad Tarcha, Ghofran Hoha, Suaad Hamsho, Maysoun Kudsi","doi":"10.1097/gh9.0000000000000462","DOIUrl":"https://doi.org/10.1097/gh9.0000000000000462","url":null,"abstract":"\u0000 \u0000 The COVID-19 pandemic has led to a post-acute syndrome that can persist for a prolonged period.\u0000 \u0000 \u0000 \u0000 The authors’ case reported a 31-years-old male presented with the sensation of sand in his eyes and a dry mouth for 3 months after infection with COVID-19 confirmed by nasopharyngeal swab 3 months ago. Laboratory tests including immunological profile were normal. Schirmer’s test was positive. He was treated with artificial tears with corticosteroid drops and water drinking. Within 15 days he noticed an improvement in his sicca symptoms.\u0000 \u0000 \u0000 \u0000 The post-acute COVID-19 syndrome can persist for a longer duration than expected, even after the acute onset of the disease. Some patients may experience ocular and oral symptoms such as dry mouth, dysgeusia, and dry eye diseases. The pathophysiology of these symptoms may be related to viral pathophysiologic changes, immunologic aberrations, and inflammatory reactions that destroy the tissue of salivary glands. Additionally, there is evidence of elevated autoantibodies in post-COVID-19 patients. Future studies are needed to understand the sequela of this infection.\u0000 \u0000 \u0000 \u0000 What makes this case special is the combination of dry eyes and dry mouth with a negative immunological profile in a young patient who had COVID without severe symptoms.\u0000","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":"34 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141843485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1097/gh9.0000000000000265
Ranjit Sah, Diptanu Paul, A. Mohanty, B. Padhi
{"title":"Outbreak of an emerging zoonoses Nipah virus: an update","authors":"Ranjit Sah, Diptanu Paul, A. Mohanty, B. Padhi","doi":"10.1097/gh9.0000000000000265","DOIUrl":"https://doi.org/10.1097/gh9.0000000000000265","url":null,"abstract":"","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":"43 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1097/gh9.0000000000000464
Bishnu Khatiwada, A. Mahat, Gopal Kumar Yadav, Bikash Duwadi, U. Mishra, Amrit Bhusal, Priti Yadav, Hensan Khadka
Urolithiasis, a frequent urologic issue, often relies on computed tomography (CT) scans, the preferred imaging technique. However, in low-income countries like Nepal, access to CT scans is limited. The authors’ study focused on comparing ultrasound (US) and CT for assessing ureteric calculi in patients with acute flank pain and examined factors influencing US detection rates in these patients. The authors conducted a cross-sectional study using purposive sampling, involving 87 participants who presented with acute flank pain at a tertiary hospital in Nepal. Ethical clearance was obtained from the institutional review board. Among the 87 patients presenting with acute flank pain, the majority were male (51, 58.62%). Of the 78 cases with CT-detected ureteric calculi, the most common locations were distal ureter (23/78, 29.49%), followed by proximal ureter (21/78, 26.92%), and pelvic-ureteric junction (PUJ) (20/78, 25.64%). Ultrasound demonstrated varying sensitivities for detecting ureteric calculi: 95.00% for PUJ, 100.00% for vesicoureteric junction (VUJ), 66.67% for proximal ureter, and 56.52% for distal ureter calculi. The highest sensitivity was observed for calculi greater than 15 mm (100%), followed by 10.1–15 mm (77.7%). Overall, ultrasound exhibited a sensitivity of 76.92%, a specificity of 100%, and an accuracy rate of 79.31% in detecting calculi. Notably, patients with hematuria had significantly higher odds of ultrasound-detected ureteric calculi (odds ratio: 36.68, 4.54–296.26, P<0.01) than those without hematuria. However, age, hydronephrosis, calculi location, and laterality were not found to be significantly associated with ultrasound detection. Due to its good sensitivity, ultrasound can serve as the first-line investigation for individuals experiencing acute flank pain, given its cost-effectiveness and radiation-free nature when compared to CT scans. CT scans should be reserved for patients exhibiting clinical symptoms of severe ureteric colic who have previously undergone a negative ultrasound (USG).
{"title":"A comparative study of ultrasonography (USG) and computed tomography for detecting ureteric calculi in patients with acute flank pain, and analysis of factors influencing ultrasound detection rates","authors":"Bishnu Khatiwada, A. Mahat, Gopal Kumar Yadav, Bikash Duwadi, U. Mishra, Amrit Bhusal, Priti Yadav, Hensan Khadka","doi":"10.1097/gh9.0000000000000464","DOIUrl":"https://doi.org/10.1097/gh9.0000000000000464","url":null,"abstract":"\u0000 \u0000 Urolithiasis, a frequent urologic issue, often relies on computed tomography (CT) scans, the preferred imaging technique. However, in low-income countries like Nepal, access to CT scans is limited. The authors’ study focused on comparing ultrasound (US) and CT for assessing ureteric calculi in patients with acute flank pain and examined factors influencing US detection rates in these patients.\u0000 \u0000 \u0000 \u0000 The authors conducted a cross-sectional study using purposive sampling, involving 87 participants who presented with acute flank pain at a tertiary hospital in Nepal. Ethical clearance was obtained from the institutional review board.\u0000 \u0000 \u0000 \u0000 Among the 87 patients presenting with acute flank pain, the majority were male (51, 58.62%). Of the 78 cases with CT-detected ureteric calculi, the most common locations were distal ureter (23/78, 29.49%), followed by proximal ureter (21/78, 26.92%), and pelvic-ureteric junction (PUJ) (20/78, 25.64%). Ultrasound demonstrated varying sensitivities for detecting ureteric calculi: 95.00% for PUJ, 100.00% for vesicoureteric junction (VUJ), 66.67% for proximal ureter, and 56.52% for distal ureter calculi. The highest sensitivity was observed for calculi greater than 15 mm (100%), followed by 10.1–15 mm (77.7%). Overall, ultrasound exhibited a sensitivity of 76.92%, a specificity of 100%, and an accuracy rate of 79.31% in detecting calculi. Notably, patients with hematuria had significantly higher odds of ultrasound-detected ureteric calculi (odds ratio: 36.68, 4.54–296.26, P<0.01) than those without hematuria. However, age, hydronephrosis, calculi location, and laterality were not found to be significantly associated with ultrasound detection.\u0000 \u0000 \u0000 \u0000 Due to its good sensitivity, ultrasound can serve as the first-line investigation for individuals experiencing acute flank pain, given its cost-effectiveness and radiation-free nature when compared to CT scans. CT scans should be reserved for patients exhibiting clinical symptoms of severe ureteric colic who have previously undergone a negative ultrasound (USG).\u0000","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":"8 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-10DOI: 10.1097/GH9.0000000000000458
Aman E. Bime, B. Bayissa
Background: ICU is a specialized department designed to serve critical care for severely ill patients. It needs an adequate number of highly trained and skilled human power and costly materials, which has limited its number and functionality in low resource settings. As a result, intensive care medicine or critical care services are poorly developed, or at most, still in the infancy stage. Due to the multifactorial limitations, ICU treatment outcomes were lower compared to high-income countries from the limited available literature. The objective of this study was to depict ICU treatment patterns and patient outcomes at low resources and limited setup. Methods: A retrospective cohort study was conducted on patients admitted to ICU from January 2017 to 31 December 2020, on a sample of 420 cases using a systematic sampling technique. Patient data were collected from the medical record and filled into a prevalidated checklist from admission to discharge or death. Data were analyzed using a statistical package for social sciences version 25.0. Result: A total of 419 patients’ data was qualified for analysis with ICU mortality being 40.8%. The majority of the admissions to the ICU were from the surgical department followed by trauma admissions. Some of the factors significantly associated with ICU mortality were: vasopressor use during the course of ICU follow up adjusted odd ratio (aOR)=4.3 with 95% CI: 1.83–10.03, P-value <0.001, patients who were put on mechanical ventilator aOR=3.6 with 95% CI: 1.90–6.63, P-value <0.001, enteral feeding aOR=0.31 at 95% CI: 0.16–0.59, P-value <0.001and admissions from internal medicine aOR=4.2, 95% CI: 1.66–10.41, P-value=0.01. Conclusion: The pattern of ICU admissions in developing countries were characterized by surgical and trauma related, younger patients, and high mortality rate. Hypotension, being on mechanical ventilator, vasopressor use, and enteral feeding were some of the factors associated with ICU outcome.
{"title":"A pattern of admission and outcome of patients admitted to the intensive care unit of a tertiary hospital in a low resource setting: a cohort study","authors":"Aman E. Bime, B. Bayissa","doi":"10.1097/GH9.0000000000000458","DOIUrl":"https://doi.org/10.1097/GH9.0000000000000458","url":null,"abstract":"Background: ICU is a specialized department designed to serve critical care for severely ill patients. It needs an adequate number of highly trained and skilled human power and costly materials, which has limited its number and functionality in low resource settings. As a result, intensive care medicine or critical care services are poorly developed, or at most, still in the infancy stage. Due to the multifactorial limitations, ICU treatment outcomes were lower compared to high-income countries from the limited available literature. The objective of this study was to depict ICU treatment patterns and patient outcomes at low resources and limited setup. Methods: A retrospective cohort study was conducted on patients admitted to ICU from January 2017 to 31 December 2020, on a sample of 420 cases using a systematic sampling technique. Patient data were collected from the medical record and filled into a prevalidated checklist from admission to discharge or death. Data were analyzed using a statistical package for social sciences version 25.0. Result: A total of 419 patients’ data was qualified for analysis with ICU mortality being 40.8%. The majority of the admissions to the ICU were from the surgical department followed by trauma admissions. Some of the factors significantly associated with ICU mortality were: vasopressor use during the course of ICU follow up adjusted odd ratio (aOR)=4.3 with 95% CI: 1.83–10.03, P-value <0.001, patients who were put on mechanical ventilator aOR=3.6 with 95% CI: 1.90–6.63, P-value <0.001, enteral feeding aOR=0.31 at 95% CI: 0.16–0.59, P-value <0.001and admissions from internal medicine aOR=4.2, 95% CI: 1.66–10.41, P-value=0.01. Conclusion: The pattern of ICU admissions in developing countries were characterized by surgical and trauma related, younger patients, and high mortality rate. Hypotension, being on mechanical ventilator, vasopressor use, and enteral feeding were some of the factors associated with ICU outcome.","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141366292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/gh9.0000000000000448
Maysoun Kudsi, Raghad Tarcha, Naram Khalayli, Ghina Haidar, Sana Btrush
The COVID-19 pandemic has led to a post-acute syndrome that can persist for an extended period. The correlation between anorexia nervosa (AN) and some autoimmune diseases has been reported. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, presented with different clinical ions and periods, affecting all ages, especially females. The coexistence of SLE and AN has been reported in rare cases. The authors present the case of a 22-year-old male with severe AN coexisting with SLE. We present a case of a 22-year-old male diagnosed with SLE. He also completely refused to eat and drink and presented with behavioral disorders and suicidal thoughts. He was on 200 mg/day of oral hydroxychloroquine, 400 units/day of vitamin D, and 1000 mg/day of oral calcium. There was no positive other history, trauma, drug addiction, or family history. AN was diagnosed according to ICD-10 and DSM-V. Physical examination revealed decreased subcutaneous tissue and muscle atrophy. The weight of the patient was 35.3 kg. Verbal contact was maintained, and psychotic symptoms were not observed. Tenderness in all joints was noticed, while swelling in both knees and right ankle joints was found. Laboratory tests revealed elevated inflammatory markers. Treatment includes a high-calorie diet administered by a feeding tube. The patient began to gain weight after 3 months. He is on 200 mg/day hydroxychloroquine, with remission till now January 2024. The novelty of our case is that it is a case of a young adult man presented with AN during mild lupus, who responded well to treatment with steroids and a high-calorie diet. Previous research has suggested the existence of a close link between food and eating disturbance and autoimmunity, and herein we provide further evidence to support this relationship by presenting a case report of an adult male with SLE and AN.
{"title":"Anorexia nervosa and systemic lupus erythematosus: a coincidence?","authors":"Maysoun Kudsi, Raghad Tarcha, Naram Khalayli, Ghina Haidar, Sana Btrush","doi":"10.1097/gh9.0000000000000448","DOIUrl":"https://doi.org/10.1097/gh9.0000000000000448","url":null,"abstract":"\u0000 \u0000 The COVID-19 pandemic has led to a post-acute syndrome that can persist for an extended period. The correlation between anorexia nervosa (AN) and some autoimmune diseases has been reported. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, presented with different clinical ions and periods, affecting all ages, especially females. The coexistence of SLE and AN has been reported in rare cases. The authors present the case of a 22-year-old male with severe AN coexisting with SLE.\u0000 \u0000 \u0000 \u0000 We present a case of a 22-year-old male diagnosed with SLE. He also completely refused to eat and drink and presented with behavioral disorders and suicidal thoughts. He was on 200 mg/day of oral hydroxychloroquine, 400 units/day of vitamin D, and 1000 mg/day of oral calcium. There was no positive other history, trauma, drug addiction, or family history. AN was diagnosed according to ICD-10 and DSM-V. Physical examination revealed decreased subcutaneous tissue and muscle atrophy. The weight of the patient was 35.3 kg. Verbal contact was maintained, and psychotic symptoms were not observed. Tenderness in all joints was noticed, while swelling in both knees and right ankle joints was found. Laboratory tests revealed elevated inflammatory markers. Treatment includes a high-calorie diet administered by a feeding tube. The patient began to gain weight after 3 months. He is on 200 mg/day hydroxychloroquine, with remission till now January 2024.\u0000 \u0000 \u0000 \u0000 The novelty of our case is that it is a case of a young adult man presented with AN during mild lupus, who responded well to treatment with steroids and a high-calorie diet.\u0000 \u0000 \u0000 \u0000 Previous research has suggested the existence of a close link between food and eating disturbance and autoimmunity, and herein we provide further evidence to support this relationship by presenting a case report of an adult male with SLE and AN.\u0000","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":" 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1097/gh9.0000000000000443
Ke Wang, Jiaming Xiao, Ying Wang, Bo Fan, Zhihong Dai, Cheng Chang, Lijie Wen, Yue Zhang, Jia Bao, Liang Wang, Zhiyu Liu
Early postoperative oral clear liquid diet has been shown to enhance postoperative recovery. However, the standard strategy for this diet has not been established. The authors’ aim was to investigate the combined effect of preoperative and early postoperative carbohydrate loading on postoperative stress and gastrointestinal function of patients by standardizing the starting time, type, volume, and concentration of carbohydrate drinks. Fifty-three patients undergoing radical prostatectomy were randomly assigned to two groups. Both groups received a carbohydrate loading of 400 ml (12.5%) overnight and 2 h before surgery. The intervention group (n=29) started a 400 ml (12.5%) carbohydrate loading 6 h after surgery and consumed it within 24 h, while the control group (n=32) drank water. The primary outcomes–postoperative fasting blood glucose, fasting insulin, C-reactive protein (CRP), interleukin-6 levels, and gastrointestinal function–were recorded. Secondary outcomes included subjective comfort assessment, the first postoperative intake of semi-fluid food time, and drainage volume. Compared with the control group, the intervention group had lower CRP levels on postoperative day 1 (POD1)/POD2 and less drainage volume on POD1. The intervention group also experienced shorter times to the first postoperative flatus and the first consumption of semi-fluid foods; their 72-h postoperative protein intake was higher than that of the control group. The results suggest that combined preoperative and postoperative carbohydrate loading can alleviate stress-induced inflammation and promote the recovery of postoperative gastrointestinal function.
{"title":"Effects of preoperative and postoperative carbohydrate loading on gastrointestinal function and stress-induced inflammation after radical prostatectomy","authors":"Ke Wang, Jiaming Xiao, Ying Wang, Bo Fan, Zhihong Dai, Cheng Chang, Lijie Wen, Yue Zhang, Jia Bao, Liang Wang, Zhiyu Liu","doi":"10.1097/gh9.0000000000000443","DOIUrl":"https://doi.org/10.1097/gh9.0000000000000443","url":null,"abstract":"\u0000 \u0000 Early postoperative oral clear liquid diet has been shown to enhance postoperative recovery. However, the standard strategy for this diet has not been established. The authors’ aim was to investigate the combined effect of preoperative and early postoperative carbohydrate loading on postoperative stress and gastrointestinal function of patients by standardizing the starting time, type, volume, and concentration of carbohydrate drinks.\u0000 \u0000 \u0000 \u0000 Fifty-three patients undergoing radical prostatectomy were randomly assigned to two groups. Both groups received a carbohydrate loading of 400 ml (12.5%) overnight and 2 h before surgery. The intervention group (n=29) started a 400 ml (12.5%) carbohydrate loading 6 h after surgery and consumed it within 24 h, while the control group (n=32) drank water. The primary outcomes–postoperative fasting blood glucose, fasting insulin, C-reactive protein (CRP), interleukin-6 levels, and gastrointestinal function–were recorded. Secondary outcomes included subjective comfort assessment, the first postoperative intake of semi-fluid food time, and drainage volume.\u0000 \u0000 \u0000 \u0000 Compared with the control group, the intervention group had lower CRP levels on postoperative day 1 (POD1)/POD2 and less drainage volume on POD1. The intervention group also experienced shorter times to the first postoperative flatus and the first consumption of semi-fluid foods; their 72-h postoperative protein intake was higher than that of the control group.\u0000 \u0000 \u0000 \u0000 The results suggest that combined preoperative and postoperative carbohydrate loading can alleviate stress-induced inflammation and promote the recovery of postoperative gastrointestinal function.\u0000","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":"228 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140278677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1097/gh9.0000000000000437
Ashna Habib, Tooba Ali, Zainab Nazir, M. O. Oduoye
{"title":"Silent struggles: the link between diabetes and the shadows of depression and suicide","authors":"Ashna Habib, Tooba Ali, Zainab Nazir, M. O. Oduoye","doi":"10.1097/gh9.0000000000000437","DOIUrl":"https://doi.org/10.1097/gh9.0000000000000437","url":null,"abstract":"","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":"209 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140282210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1097/gh9.0000000000000273
Aymar Akilimali, M. O. Oduoye, Hugues Cakwira, Adam F. Mohammed, Chrispin Biamba, Arama Umulkhairah, Emery Mugabe, M. Sagide, Bonk Muhoza, Linda Atulinda, I. I. Okon, Fabrice Kibukila, Olivier Nyakio
{"title":"Ebola virus disease outbreak in Uganda: the way forward","authors":"Aymar Akilimali, M. O. Oduoye, Hugues Cakwira, Adam F. Mohammed, Chrispin Biamba, Arama Umulkhairah, Emery Mugabe, M. Sagide, Bonk Muhoza, Linda Atulinda, I. I. Okon, Fabrice Kibukila, Olivier Nyakio","doi":"10.1097/gh9.0000000000000273","DOIUrl":"https://doi.org/10.1097/gh9.0000000000000273","url":null,"abstract":"","PeriodicalId":306111,"journal":{"name":"International Journal of Surgery: Global Health","volume":"412 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140275082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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