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Evinacumab—a treatment for homozygous familial hypercholesterolemia evinacumab -治疗纯合子家族性高胆固醇血症
Pub Date : 2023-08-25 DOI: 10.1097/GH9.0000000000000254
A. Basaria, Ismat Fatima, N. Raufi
A rare life-threatening condition known as homozygous familial hypercholesterolemia (HoFH) is characterized by markedly elevated levels of low-density lipoprotein cholesterol (LDL-C) in the blood and accelerated, premature atherosclerotic cardiovascular disease (ACVD) [1] . It is clinically characterized by extensive xanthomas, marked premature and progressive ACVD
纯合子家族性高胆固醇血症(HoFH)是一种罕见的危及生命的疾病,其特征是血液中低密度脂蛋白胆固醇(LDL-C)水平显著升高,加速过早动脉粥样硬化性心血管疾病(ACVD)[1]。临床表现为广泛的黄瘤,明显的早发性和进行性ACVD
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引用次数: 0
Neglected tropical diseases in conflict-affected areas in Africa: an unknown burden 非洲受冲突影响地区被忽视的热带病:一个未知的负担
Pub Date : 2023-08-25 DOI: 10.1097/gh9.0000000000000250
A. Aborode, Agwuna Favour Obianuju, Lukman Lawal, Nasir Abdulrasheed, Rusab Baig, Tijanu Yusuf Olatunji, Al-Mansur Sumayya Auwal, A. Olorukooba, Fatima Abdirazak Ahmed
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引用次数: 0
Assessment of computed tomography for the diagnosis of exudative and transudative pleural effusion 计算机断层扫描诊断渗出性和渗出性胸腔积液的价值评价
Pub Date : 2023-08-24 DOI: 10.1097/GH9.0000000000000252
Subash Pathak, Asim Mahat, G. Yadav, U. Mishra, Bikash Duwadi, Mamata Bhattarai, Alisha Rijal
Introduction: The basic computed tomography (CT) characteristics of pleural effusion (PE) were analyzed, and the association between demographic factors and prominent CT findings with different types of PE was assessed. The individual CT characteristics and Light’s criteria for exudative PE were also evaluated. In addition, a cutoff for attenuation values of CT scans for exudative PE was determined. Methods: A cross-sectional study among 92 participants with PE was carried out at Bir Hospital, Kathmandu, Nepal. The χ2 test, logistic regression analysis, and diagnostic statistics were calculated. The ethical clearance was obtained from the institutional review committee of Institutional review board of National Academy of Medical Sciences (NAMS), Bir Hospital (Ref. 876/076/77). Results: The study examined 92 cases of PE, with 78.3% occurring in males and the majority affecting individuals aged 55–74 years old. Results showed that on CT scans, pleural thickening [odds ratio (OR): 13.89, 95% CI: 4.96–38.86, P < 0.05], pleural nodules (OR: 12.72, 95% CI: 2.64–61.18, P < 0.05) and loculations (OR: 13.46, 95% CI: 4.03–44.89, P < 0.05) were significantly associated with exudative PE. Of these, pleural nodules had the highest specificity (96.4%) and positive likelihood ratio (9), whereas pleural thickening had the highest sensitivity (70.3%). When using the criterion “pleural fluid Lactate Dehydrogenase concentration as positive if it was over two-thirds of the upper limit of normal serum Lactate Dehydrogenase,” the CT scan had a positive likelihood ratio of 22.52. The study also found that an attenuation value ≥9.70 HU could indicate an exudative PE (area under the curve: 0.80, 95% CI: 0.70–0.90, P < 0.05). Conclusion: The CT characteristics, such as pleural thickening, pleural nodules, and loculations, were more likely to be present in exudative PE. In addition, the attenuation values of PE could also determine its nature as either exudate or transudate, with an attenuation value of >9.70 HU indicating an exudative PE.
前言:分析胸腔积液(PE)的基本CT特征,评估人口学因素与不同类型PE突出CT表现的相关性。并评价了个体CT特征和Light的渗出性PE诊断标准。此外,确定了渗出性PE的CT扫描衰减值的截止值。方法:对尼泊尔加德满都Bir医院92名PE患者进行横断面研究。进行χ2检验、logistic回归分析和诊断统计。伦理许可由国家医学科学院(NAMS)机构审查委员会机构审查委员会,Bir医院(参考文献876/076/77)获得。结果:该研究检查了92例PE,其中78.3%发生在男性中,大多数患者年龄在55-74岁之间。结果CT扫描显示,胸膜增厚[比值比(OR): 13.89, 95% CI: 4.96 ~ 38.86, P < 0.05]、胸膜结节(OR: 12.72, 95% CI: 2.64 ~ 61.18, P < 0.05)和胸膜位置(OR: 13.46, 95% CI: 4.03 ~ 44.89, P < 0.05)与渗出性PE显著相关。其中胸膜结节的特异性最高(96.4%),阳性似然比最高(9),而胸膜增厚的敏感性最高(70.3%)。以“胸膜液乳酸脱氢酶浓度超过正常血清乳酸脱氢酶上限三分之二为阳性”为标准,CT扫描的阳性似然比为22.52。研究还发现,衰减值≥9.70 HU可提示渗出性PE(曲线下面积:0.80,95% CI: 0.70-0.90, P < 0.05)。结论:渗出性PE更容易出现胸膜增厚、胸膜结节、定位等CT表现。此外,PE的衰减值也可以判断其是渗出型还是渗出型,衰减值>9.70 HU为渗出型PE。
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引用次数: 0
Insights on the tomato flu outbreak in India: could this outbreak be contained? 关于印度番茄流感爆发的见解:这次爆发能被控制吗?
Pub Date : 2023-08-23 DOI: 10.1097/GH9.0000000000000256
Mahad Ahmed Khan, W. Bilal, Abdullah Nadeem, L. I. Vohra, N. Raufi
Children in India are being infected with a rare, dangerous virus known as “ tomato fl u ” [1] . It is thought of being either a novel variety of the viral hand, foot, and mouth disease or a consequence of chikungunya or dengue fever [2] . According to the Centers for Disease Control and Prevention, hand, foot, and mouth disease is an extremely infectious disease caused by the coxsackievirus A16 that spreads rapidly through an affected person ’ s nasal and oral secretions, excretions, and blister fl uid. As per experts, young children, particularly between 1 and 9 years of age are more susceptible to contracting this disease owing to their compromised immune systems, with the highest prevalence seen in children under 5 years of age [1] . The fi rst case of tomato fl u was reported on May 6, 2022, in the Kollam district of Kerala in India with government health care facilities subsequently documenting infection in further 82 children by July 26, 20222. The Regional Medical Research Centre in Bhubaneswar revealed that an additional 26 children in the state of Odisha had contracted the illness. Other than Kerala, Tamil Nadu, and Odisha, no other parts of India have experienced the virus ’ s effects as yet [3] . The hallmark of this disease is blisters all over the body, especially the hands, feet, and oral cavity characterized by a tomato-red hue and the size of a tiny tomato, giving it the moniker “ tomato fl u or tomato fever. ” Complimenting it are symptoms, such as pyrexia, exhaustion, and body pains, reminiscing about coronavirus disease 2019 (COVID-19). Doctors have also noticed a loss of nails and lesions in unusual places, including the buttocks [4,5] . The incubation period of the disease is 5 – 7 days with diagnosis made by affected individuals going through molecular and serological tests for the diagnosis of the Zika virus,
印度的儿童正在感染一种罕见的危险病毒,这种病毒被称为“番茄流感”[1]。人们认为它要么是病毒性手足口病的一种新变种,要么是基孔肯雅热或登革热的后果。根据疾病控制和预防中心的说法,手足口病是一种由柯萨奇病毒A16引起的极具传染性的疾病,它通过患者的鼻腔和口腔分泌物、排泄物和水疱液迅速传播。据专家介绍,幼儿,特别是1至9岁的儿童,由于免疫系统受损,更容易感染这种疾病,其中5岁以下儿童的患病率最高。第一例番茄流感病例于2022年5月6日在印度喀拉拉邦的科拉姆地区报告,政府卫生保健机构随后记录到2022年7月26日又有82名儿童感染。布巴内斯瓦尔地区医学研究中心透露,奥里萨邦又有26名儿童感染了这种疾病。除了喀拉拉邦、泰米尔纳德邦和奥里萨邦之外,印度的其他地区还没有经历过这种病毒的影响。这种疾病的特征是全身起泡,尤其是手、脚和口腔,其特征是番茄红的色调和小番茄的大小,因此被称为“番茄热”。与之相对应的是发热、疲惫、身体疼痛等症状,让人想起2019冠状病毒病(COVID-19)。医生也注意到指甲的缺失和不寻常部位的病变,包括臀部[4,5]。该病的潜伏期为5 - 7天,由受影响个体通过分子和血清学检测作出诊断,以诊断寨卡病毒。
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引用次数: 0
The tree of beautification! Sudden increase of heat waves and its impact on public health in Bangladesh: need early intervention 美化之树!孟加拉国热浪突然增加及其对公共卫生的影响:需要早期干预
Pub Date : 2023-08-23 DOI: 10.1097/gh9.0000000000000230
M. Al-Mamun, Nurul Islam Uzzal
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引用次数: 0
The hidden diagnosis: hypogonadotropic hypogonadism unveiled in a rare Fanconi syndrome case—a case report and literature review 隐匿的诊断:罕见的范可尼综合征揭示的促性腺功能减退症1例报告并文献复习
Pub Date : 2023-08-22 DOI: 10.1097/GH9.0000000000000255
Syeda Mahrukh Fatima Zaidi, M. Siddiq, S. Qamar, S. M. Hasan, Syeda Dua e Zehra Zaidi, S. Kashif, M. Alam
Introduction and importance: Fanconi syndrome affects kidney function, whereas hypogonadotropic hypogonadism (HH) is gonadal failure due to deficient hormones. Diagnosis involves assays and imaging, whereas treatment targets cause and fluid balance. Here, there is a reported co-occurrence in Pakistan. Case presentation: A 14-year-old girl presented with joint pain and developmental delay. Physical examination revealed wrist widening, genu-varum, and underdeveloped secondary sexual characteristics. Laboratory findings confirmed Fanconi syndrome and coincidental ultrasound findings revealed HH. The patient received treatment in the form of oral medications and supplements to manage the condition. Clinical discussion: Fanconi syndrome is a complex disorder affecting the proximal tubule of the kidneys, leading to impaired reabsorption of various substances. In this case, potential genetic and acquired causes were ruled out, including inborn errors of metabolism and heavy metal intoxication. Prolonged valproic acid use was also considered but not confirmed as the cause. The patient also presented with HH, which is unrelated but coexisting. Treatment for Fanconi syndrome focuses on correcting electrolyte imbalances, whereas hormone replacement therapy is considered for HH. The patient’s progress and response to treatment are under careful monitoring. Conclusion: This case highlights the need for further research and comprehensive diagnostic evaluation to better understand the association between Fanconi syndrome and HH, emphasizing the importance of early diagnosis and management to prevent long-term complications.
简介及重要性:范可尼综合征影响肾功能,而促性腺功能减退症(HH)是由于激素缺乏导致的性腺功能衰竭。诊断包括化验和成像,而治疗的目标是病因和体液平衡。据报道,巴基斯坦也发生了同样的情况。病例介绍:一名14岁女孩,表现为关节疼痛和发育迟缓。体格检查显示手腕变宽,膝内翻,第二性征发育不全。实验室结果证实范可尼综合征和巧合的超声结果显示HH。患者接受了口服药物和补充剂的治疗来控制病情。临床讨论:Fanconi综合征是一种影响肾脏近端小管的复杂疾病,导致多种物质的重吸收受损。在这种情况下,排除了潜在的遗传和后天原因,包括先天性代谢错误和重金属中毒。长期使用丙戊酸也被认为是原因,但未被证实。患者还出现HH,两者不相关但并存。治疗范可尼综合征的重点是纠正电解质失衡,而激素替代疗法被认为是HH。病人的病情进展和对治疗的反应正在密切监测之下。结论:本病例需要进一步的研究和全面的诊断评估,以更好地了解Fanconi综合征与HH的关系,强调早期诊断和治疗对预防长期并发症的重要性。
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引用次数: 0
Reimaging of health care: Tanzania’s quest and bold step towards universal health coverage deploying universal health insurance as a catalyst 重新构想卫生保健:坦桑尼亚对全民健康覆盖的追求和大胆的一步,利用全民健康保险作为催化剂
Pub Date : 2023-08-21 DOI: 10.1097/gh9.0000000000000253
S. A. Kessy, J. R. Tibenderana
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引用次数: 0
XBB.1.16: A new ultimatum for global public health XBB.1.16:全球公共卫生新的最后通牒
Pub Date : 2023-08-16 DOI: 10.1097/gh9.0000000000000201
Md. Imam Hossain, Fatema Hasan Kaifa, Prosun Bhattacharya, Md. Aminul Islam
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引用次数: 0
The outbreak of anthrax amid COVID-19 in Kenya: understanding its surgical implications and possible solutions 肯尼亚COVID-19期间炭疽的爆发:了解其外科影响和可能的解决方案
Pub Date : 2023-08-14 DOI: 10.1097/gh9.0000000000000240
M. O. Oduoye, Abubakar Nazir, Aymar Akilimali, Hugues Cakwira, Martin Sagide Rogose, Chrispin Biamba, Awais Nazir, Bridget Uzoamaka Chukwudile, Alia Farooq, David Banyanga, Fabrice Kibukila, Olivier Nyakio
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引用次数: 0
The rise in autism spectrum disease: is the Pakistani population aware of the symptoms? 自闭症谱系疾病的上升:巴基斯坦人口是否意识到这些症状?
Pub Date : 2023-08-11 DOI: 10.1097/gh9.0000000000000247
B. Asghar, Fasih Asghar, Eymaan Riaz, Z. Iqbal, Saiyeda Maha Fatima, Hareer Fatima
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引用次数: 0
期刊
International Journal of Surgery: Global Health
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