Pub Date : 2021-01-01DOI: 10.52547/JARUMS.20.2.200
A. Soleimanzadeh, A. Jalali, A. Abdullahi, Mohammad Moein Sabzeie
Background & objectives: The present study investigated the effects of royal jelly on lead acetate induced toxicity on sperm parameters, reproductive hormone assay, and bak gene expression in NMRI male mice. Methods: In this study, fifty four male mice were randomly divided into nine groups: control group (without royal jelly) (n=6); sham group(10 ml normal saline) (n=6); lead group (1000 ppm, oral) (n=6); Group 4: royal jelly (100 mg/kg/day, oral) (n=6); Group 5: royal jelly (250 mg/kg/day, oral)(n=6); Group 6: royal jelly (500 mg/kg/day, oral)(n=6); Group 7: royal jelly (100 mg/kg/day, oral) + 1000 ppm lead (n=6); Group 8: royal jelly (250 mg/kg/day, oral) + 1000 ppm lead (n=6) and Group 9: royal jelly (500 mg/kg/day, oral) + 1000 ppm lead (n=6). On day 35, blood samples were collected from anaesthetized mice by cardiac puncture to assess reproductive hormones and the testes were harvested for determination of sperm parameters and expression bak gene. Sperm parameters including motility, viability, DNA damage, morphology and total antioxidant capacity (TAC) levels were determined. Results: The results showed that administration of royal jelly significantly enhanced sperm parameters and all reproductive hormone levels compared to control mice, (p<0.05). Also, treatment with lead acetate caused a significant reduction in levels of all reproductive hormones and a significant diminution in sperm motility, morphology, viability; with an increase in percentage of dead spermatocytes (p<0.05). The co-administration of the 250 and 500 mg/kg/day royal jelly with lead acetate could ameliorate the deleterious effects of lead acetate resulting in a significant increase in sperm parameters and all reproductive hormones and increase the total antioxidant capacity (TAC) levels (p<0.05). Also, the expression of bak gene in all treated (sham, royal jelly groups) and control groups was significantly lower than the lead acetate group (p<0.05). Conclusion: In conclusion, our findings suggest that the royal jelly has a beneficial effect on male reproductive parameters following lead acetate induced toxicity in mice.
{"title":"Protective Effect of Royal Jelly on Sperm Parameters and bak Gene Expression Following Lead Acetate poisoning in Mice","authors":"A. Soleimanzadeh, A. Jalali, A. Abdullahi, Mohammad Moein Sabzeie","doi":"10.52547/JARUMS.20.2.200","DOIUrl":"https://doi.org/10.52547/JARUMS.20.2.200","url":null,"abstract":"Background & objectives: The present study investigated the effects of royal jelly on lead acetate induced toxicity on sperm parameters, reproductive hormone assay, and bak gene expression in NMRI male mice. Methods: In this study, fifty four male mice were randomly divided into nine groups: control group (without royal jelly) (n=6); sham group(10 ml normal saline) (n=6); lead group (1000 ppm, oral) (n=6); Group 4: royal jelly (100 mg/kg/day, oral) (n=6); Group 5: royal jelly (250 mg/kg/day, oral)(n=6); Group 6: royal jelly (500 mg/kg/day, oral)(n=6); Group 7: royal jelly (100 mg/kg/day, oral) + 1000 ppm lead (n=6); Group 8: royal jelly (250 mg/kg/day, oral) + 1000 ppm lead (n=6) and Group 9: royal jelly (500 mg/kg/day, oral) + 1000 ppm lead (n=6). On day 35, blood samples were collected from anaesthetized mice by cardiac puncture to assess reproductive hormones and the testes were harvested for determination of sperm parameters and expression bak gene. Sperm parameters including motility, viability, DNA damage, morphology and total antioxidant capacity (TAC) levels were determined. Results: The results showed that administration of royal jelly significantly enhanced sperm parameters and all reproductive hormone levels compared to control mice, (p<0.05). Also, treatment with lead acetate caused a significant reduction in levels of all reproductive hormones and a significant diminution in sperm motility, morphology, viability; with an increase in percentage of dead spermatocytes (p<0.05). The co-administration of the 250 and 500 mg/kg/day royal jelly with lead acetate could ameliorate the deleterious effects of lead acetate resulting in a significant increase in sperm parameters and all reproductive hormones and increase the total antioxidant capacity (TAC) levels (p<0.05). Also, the expression of bak gene in all treated (sham, royal jelly groups) and control groups was significantly lower than the lead acetate group (p<0.05). Conclusion: In conclusion, our findings suggest that the royal jelly has a beneficial effect on male reproductive parameters following lead acetate induced toxicity in mice.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":"20 1","pages":"200-211"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70687632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.52547/JARUMS.20.2.280
Seyed Ali Bazghandi, Somayeh Safarirad, M. Arzanlou, H. Peeri-Dogaheh, Hossein Ali-Mohammadi, F. Khademi
Background & objectives: Bacterial antibiotic resistance is becoming a global health crisis. The aim of this descriptive, cross-sectional study was to investigate the prevalence of multidrug-resistant Pseudomonas aeruginosa strains in Ardabil. Methods: During 9 months, between July 2019 and March 2020, 50 strains of Pseudomonas aeruginosa were collected from different clinical specimens in four hospitals of Ardabil and the prevalence of MDR, XDR and PDR strains of Pseudomonas aeruginosa were evaluated. Antibiotic susceptibility testing was assessed using the disk diffusion method. Results: In the present study, the prevalence of MDR, XDR and PDR strains of Pseudomonas aeruginosa were 52%, 40% and 14%, respectively. Conclusion: Due to high prevalence of multidrug-resistant strains of Pseudomonas aeruginosa in Ardabil, continuous monitoring of the antibiotic resistance trend in clinical isolates in order to select the best medication is necessary.
{"title":"Prevalence of Multidrug-resistant Pseudomonas aeruginosa Strains in Ardabil","authors":"Seyed Ali Bazghandi, Somayeh Safarirad, M. Arzanlou, H. Peeri-Dogaheh, Hossein Ali-Mohammadi, F. Khademi","doi":"10.52547/JARUMS.20.2.280","DOIUrl":"https://doi.org/10.52547/JARUMS.20.2.280","url":null,"abstract":"Background & objectives: Bacterial antibiotic resistance is becoming a global health crisis. The aim of this descriptive, cross-sectional study was to investigate the prevalence of multidrug-resistant Pseudomonas aeruginosa strains in Ardabil. Methods: During 9 months, between July 2019 and March 2020, 50 strains of Pseudomonas aeruginosa were collected from different clinical specimens in four hospitals of Ardabil and the prevalence of MDR, XDR and PDR strains of Pseudomonas aeruginosa were evaluated. Antibiotic susceptibility testing was assessed using the disk diffusion method. Results: In the present study, the prevalence of MDR, XDR and PDR strains of Pseudomonas aeruginosa were 52%, 40% and 14%, respectively. Conclusion: Due to high prevalence of multidrug-resistant strains of Pseudomonas aeruginosa in Ardabil, continuous monitoring of the antibiotic resistance trend in clinical isolates in order to select the best medication is necessary.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70688022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.52547/JARUMS.20.2.212
M. Valizadeh, E. Babaei, R. Sharifi, A. Yazdanbod
Background & objectives: Colon cancer is a common disease in the world that causes high mortality in affected people. The lack of appropriate diagnostic and prognostic markers has led to the failure in early diagnosis of colorectal malignancies. MicroRNAs play an important role in controlling the expression of target genes involved in the development and progression of colon cancer. The aim of the present study was the bioinformatics identification of microRNAs with distinct expression in cancerous and non-cancerous colon samples. Methods: This type of study was theoretical bioinformatics and microarray data of 1513 colon cancer samples with the accession number of GSE115513 were obtained from the GEO site and marker genes were selected by using R program. Target genes of the identified microRNAs were provided by TARGETSCAN software and finally, the graphical network was plotted in Cytoscape software. Results: Analysis of microarray data showed that has-miR-663b, has-miR-650, has-miR-175p, has-miR-4539 and has-miR-501-3p have biomarker potential in cancer samples. Statistical analysis and investigation of the target genes indicated that miR-663b (ROC=0.8965, p=0.001) and has-miR-650 (ROC=0.9104, p=0.001) had significant distinct expression between cancerous and non-tumor margins with biomarker potential. Conclusion: The has-miR-663b and has-miR-650 genes can be used as diagnostic markers to distinguish colon cancer from non-cancerous samples.
{"title":"Bioinformatic-based Identification of MicroRNAs with Biomarker Potential in Colon Cancer from Microarray Data","authors":"M. Valizadeh, E. Babaei, R. Sharifi, A. Yazdanbod","doi":"10.52547/JARUMS.20.2.212","DOIUrl":"https://doi.org/10.52547/JARUMS.20.2.212","url":null,"abstract":"Background & objectives: Colon cancer is a common disease in the world that causes high mortality in affected people. The lack of appropriate diagnostic and prognostic markers has led to the failure in early diagnosis of colorectal malignancies. MicroRNAs play an important role in controlling the expression of target genes involved in the development and progression of colon cancer. The aim of the present study was the bioinformatics identification of microRNAs with distinct expression in cancerous and non-cancerous colon samples. Methods: This type of study was theoretical bioinformatics and microarray data of 1513 colon cancer samples with the accession number of GSE115513 were obtained from the GEO site and marker genes were selected by using R program. Target genes of the identified microRNAs were provided by TARGETSCAN software and finally, the graphical network was plotted in Cytoscape software. Results: Analysis of microarray data showed that has-miR-663b, has-miR-650, has-miR-175p, has-miR-4539 and has-miR-501-3p have biomarker potential in cancer samples. Statistical analysis and investigation of the target genes indicated that miR-663b (ROC=0.8965, p=0.001) and has-miR-650 (ROC=0.9104, p=0.001) had significant distinct expression between cancerous and non-tumor margins with biomarker potential. Conclusion: The has-miR-663b and has-miR-650 genes can be used as diagnostic markers to distinguish colon cancer from non-cancerous samples.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42522249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.52547/JARUMS.20.2.269
Hassan Ghobadi, A. Abedi, Mohammad Reza Aslani, Aminollah Mottahari
Background & objectives: The respiratory system is one of the areas that are most vulnerable to unhealthy workplace injuries. One of the most common occupational diseases, are illnesses and respiratory complications in employees who exposed to harmful pollutants in the workplace. Flour powder is a complex organic particle with different components. These ingredients include wheat bran, pollen, starch particles and a variety of bacteria. The high temperature of the bakery oven and the flour in the bakers' work environment can cause allergic and respiratory disorders. Evaluation of pulmonary function tests (spirometry) plays an important role in the diagnosis and management of lung diseases such as asthma, chronic obstructive pulmonary disease and threatening disease. The aim of this study was to evaluate pulmonary function tests and compare it with non-bakers and healthy people in Ardabil traditional bakers. Methods: Lung function tests including forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), maximal expiratory airflow velocity (PEF), maximal expiratory airflow velocity at 75%, 50%, and 25% of vital capacity (MEF75, MEF50, MEF25) and respiratory and allergic symptoms of 51 traditional male bakers and 51 non-bakers in the same age with other occupations were compared. Respiratory and allergic symptoms using a standard questionnaire including jobrelated respiratory symptoms such as cough, sputum, shortness of breath, and job-related allergic symptoms. In each phase, in addition to calculating the mean and standard deviation, t-test used to compare the means, the probability of error less than 5% considered significant. Results: In the present study, there was a significant difference between the case group and the control group in pulmonary parameters. In addition, there was no significant difference between the level of education, type of bakery, number of working hours per day and BMI of bakers. There was a significant relationship between work experience (year) and FVC, FEV1, FEV1 percentage and FEF50%. There was also a significant relationship between the age of bakers and the all parameters above, except FVC, and there was a significant difference between different tasks in bakeries only in the case of FEF50%. Conclusion: In control subjects, pulmonary parameters decreased with age, but in bakers, this trend is more severe and needs to follow up. The present study showed that traditional bakers in Ardabil are at risk for obstructive respiratory diseases. High oven temperature and exposure to irritants such as wheat flour may play an important role. Preventive tools such as proper ventilation and protective equipment needed.
{"title":"Assessment of Pulmonary Function Tests in Traditional Male Bakers in Ardabil City","authors":"Hassan Ghobadi, A. Abedi, Mohammad Reza Aslani, Aminollah Mottahari","doi":"10.52547/JARUMS.20.2.269","DOIUrl":"https://doi.org/10.52547/JARUMS.20.2.269","url":null,"abstract":"Background & objectives: The respiratory system is one of the areas that are most vulnerable to unhealthy workplace injuries. One of the most common occupational diseases, are illnesses and respiratory complications in employees who exposed to harmful pollutants in the workplace. Flour powder is a complex organic particle with different components. These ingredients include wheat bran, pollen, starch particles and a variety of bacteria. The high temperature of the bakery oven and the flour in the bakers' work environment can cause allergic and respiratory disorders. Evaluation of pulmonary function tests (spirometry) plays an important role in the diagnosis and management of lung diseases such as asthma, chronic obstructive pulmonary disease and threatening disease. The aim of this study was to evaluate pulmonary function tests and compare it with non-bakers and healthy people in Ardabil traditional bakers. Methods: Lung function tests including forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), maximal expiratory airflow velocity (PEF), maximal expiratory airflow velocity at 75%, 50%, and 25% of vital capacity (MEF75, MEF50, MEF25) and respiratory and allergic symptoms of 51 traditional male bakers and 51 non-bakers in the same age with other occupations were compared. Respiratory and allergic symptoms using a standard questionnaire including jobrelated respiratory symptoms such as cough, sputum, shortness of breath, and job-related allergic symptoms. In each phase, in addition to calculating the mean and standard deviation, t-test used to compare the means, the probability of error less than 5% considered significant. Results: In the present study, there was a significant difference between the case group and the control group in pulmonary parameters. In addition, there was no significant difference between the level of education, type of bakery, number of working hours per day and BMI of bakers. There was a significant relationship between work experience (year) and FVC, FEV1, FEV1 percentage and FEF50%. There was also a significant relationship between the age of bakers and the all parameters above, except FVC, and there was a significant difference between different tasks in bakeries only in the case of FEF50%. Conclusion: In control subjects, pulmonary parameters decreased with age, but in bakers, this trend is more severe and needs to follow up. The present study showed that traditional bakers in Ardabil are at risk for obstructive respiratory diseases. High oven temperature and exposure to irritants such as wheat flour may play an important role. Preventive tools such as proper ventilation and protective equipment needed.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41754203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.52547/JARUMS.20.2.254
A. Homayouni‐Rad, Parvin Oroojzadeh, A. Abbasi
Background & objectives: Probiotic dairy products as a functional food have a positive effect on the health of consumers that have been confirmed by scientific evidence. Yoghurt is considered as one of the most popular dairy foods in Iran, which the incorporation of the probiotics into the yoghurt matrix can improve their microbiological and sensory properties and subsequently will play a vital role in promoting the health of the community. The aim of this study was to investigate the effect of yeast Kluyveromyces marxianus on the microbial and sensorial properties of probiotic yoghurt during refrigerated storage. Methods: In this in vitro study, the yeast Kluyveromyces marxianus PTCC=5189 was used to produce probiotic yoghurt and Aspergillus parasiticus PTCC=5018 (IR 63) and Penicillium chrysogenum PTCC=5074 were used as known pathogens and the main spoilage agents in yoghurt. Changes in the number of probiotic yeasts and spoilage species as well as the sensory acceptability of the samples during 28 days of storage at 4°C were evaluated and compared with the control samples. Results: The population of both species, involved in yoghurt spoilage, during refrigeration were significantly reduced by the presence of Kluyveromyces marxianus (p<0.01). After 28 days of storage, the number of Kluyveromyces marxianus was at the recommended level of the International Dairy Federation with a 7.35 log CFU/g. The sensory evaluation results demonstrated that the control yoghurt samples were more acceptable. Conclusion: Kluyveromyces marxianus has a significant effect on improving microbiological properties and can be used in the formulation and production of probiotic yoghurt with high storage capability and optimal sensory acceptability.
背景与目的:益生菌乳制品作为一种功能性食品，对消费者的健康有积极的影响，这已经被科学证据所证实。酸奶被认为是伊朗最受欢迎的乳制品之一，在酸奶基质中加入益生菌可以改善其微生物和感官特性，从而在促进社区健康方面发挥至关重要的作用。本研究旨在探讨酵母马氏克鲁维菌对益生菌酸奶冷藏过程中微生物和感官特性的影响。方法:以马氏克鲁维菌PTCC=5189酵母为原料生产益生菌酸奶，以寄生曲霉PTCC=5018 (IR 63)和青霉菌PTCC=5074为已知病原菌和酸奶的主要腐坏剂。对样品在4℃条件下保存28 d期间的益生菌酵母菌数量和腐败种类的变化以及感官可接受性进行了评价，并与对照样品进行了比较。结果:在冷藏过程中，由于马氏克卢维菌的存在，这两种参与酸奶腐败的物种的数量显著减少(p<0.01)。贮藏28 d后，马氏克卢维菌数量达到国际乳业联合会推荐水平，为7.35 log CFU/g。感官评价结果表明，对照酸奶样品可接受度较高。结论:马氏克鲁维菌具有显著的改善微生物特性的作用，可用于制备和生产具有高贮藏性能和最佳感官接受度的益生菌酸奶。
{"title":"The Effect of Yeast Kluyveromyces marxianus as a Probiotic on the Microbiological and Sensorial Properties of Set Yoghurt during Refrigerated Storage","authors":"A. Homayouni‐Rad, Parvin Oroojzadeh, A. Abbasi","doi":"10.52547/JARUMS.20.2.254","DOIUrl":"https://doi.org/10.52547/JARUMS.20.2.254","url":null,"abstract":"Background & objectives: Probiotic dairy products as a functional food have a positive effect on the health of consumers that have been confirmed by scientific evidence. Yoghurt is considered as one of the most popular dairy foods in Iran, which the incorporation of the probiotics into the yoghurt matrix can improve their microbiological and sensory properties and subsequently will play a vital role in promoting the health of the community. The aim of this study was to investigate the effect of yeast Kluyveromyces marxianus on the microbial and sensorial properties of probiotic yoghurt during refrigerated storage. Methods: In this in vitro study, the yeast Kluyveromyces marxianus PTCC=5189 was used to produce probiotic yoghurt and Aspergillus parasiticus PTCC=5018 (IR 63) and Penicillium chrysogenum PTCC=5074 were used as known pathogens and the main spoilage agents in yoghurt. Changes in the number of probiotic yeasts and spoilage species as well as the sensory acceptability of the samples during 28 days of storage at 4°C were evaluated and compared with the control samples. Results: The population of both species, involved in yoghurt spoilage, during refrigeration were significantly reduced by the presence of Kluyveromyces marxianus (p<0.01). After 28 days of storage, the number of Kluyveromyces marxianus was at the recommended level of the International Dairy Federation with a 7.35 log CFU/g. The sensory evaluation results demonstrated that the control yoghurt samples were more acceptable. Conclusion: Kluyveromyces marxianus has a significant effect on improving microbiological properties and can be used in the formulation and production of probiotic yoghurt with high storage capability and optimal sensory acceptability.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":"20 1","pages":"254-268"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70687323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & objectives: The purpose of this study was to investigate the effectiveness of Group schema therapy on social anxiety and its specific symptoms in blind and visually impaired people. Methods: This study was a semi -experimental study with pre-test, post-test and follow-up test with a control group .For this purpose, the statistical population of study ,included all blind and low-vision people admitted to Isfahan's Ababasir Educational Institute. 26 participants were selected by available sampling and were randomly assigned to the experimental group (13 persons) and the control group (13 persons). The experimental group was trained on 10 sessions (weekly) according to schema therapy in Yang protocol, while control group did not receive any training. Data were collected by self-report method (Social Phobia Inventory) and analyzed using covariance test by SPSS-21 software . Results: Results showed a significant difference between social anxiety in the experimental group, when entering the study, immediately after treatment, and 1 month after treatment; but no significant difference was observed in the control group. Conclusions: One of the useful and effective treatments for refractory, ambiguous and longterm disorders that have their roots in childhood is Yang's scheme therapy and also, group therapy is one of the most important factors in the effectiveness of this treatment model in the present study.
{"title":"The Effectiveness of Group Schema Therapy on Social Anxiety and Its Specific Symptoms in Blind and Visually Impaired People","authors":"Marzieh Gashouli, Azra Mohammadpanah Ardakan, Azadeh Choobforoushzadeh","doi":"10.52547/jarums.20.4.519","DOIUrl":"https://doi.org/10.52547/jarums.20.4.519","url":null,"abstract":"Background & objectives: The purpose of this study was to investigate the effectiveness of Group schema therapy on social anxiety and its specific symptoms in blind and visually impaired people. Methods: This study was a semi -experimental study with pre-test, post-test and follow-up test with a control group .For this purpose, the statistical population of study ,included all blind and low-vision people admitted to Isfahan's Ababasir Educational Institute. 26 participants were selected by available sampling and were randomly assigned to the experimental group (13 persons) and the control group (13 persons). The experimental group was trained on 10 sessions (weekly) according to schema therapy in Yang protocol, while control group did not receive any training. Data were collected by self-report method (Social Phobia Inventory) and analyzed using covariance test by SPSS-21 software . Results: Results showed a significant difference between social anxiety in the experimental group, when entering the study, immediately after treatment, and 1 month after treatment; but no significant difference was observed in the control group. Conclusions: One of the useful and effective treatments for refractory, ambiguous and longterm disorders that have their roots in childhood is Yang's scheme therapy and also, group therapy is one of the most important factors in the effectiveness of this treatment model in the present study.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47841509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.52547/jarums.20.4.551
Alireza Shiroyeh, Farshad Emami, M. Sanaee, Rasol Tarighi
Background & objectives: Preptin and adropine are peptide hormones that play an important role in the controlling of obesity by regulation of carbohydrate metabolism. The purpose of the present study was to investigate the effect of aerobic training on preptin, adropine and insulin resistance in men with overweight. Methods: In this clinical trial study, 18 overweight and obese men (age 58.39±3.92, body mass index 28.75±1.23) were selected and randomly divided into two groups (control and exercise). Exercise group participated in an aerobic exercise program for eight weeks, five sessions per week (with an intensity of 65 to 85% of maximum heart rate, 40 minutes). Two days before and after the protocol, fasting blood samples were taken. Preptin and adropine were measured by ELISA. Data were tested using independent t-test and ANCOVA at a significance level of p<0.05. Results: The level of preptin in the experimental group was significantly reduced compared to the control group (p=0.001) and the pretest (p=0.000). Also, the adropine level in the experimental group increased significantly compared to the control group (p=0.000) and the pretest (p=0.000). Also, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) values in the exercise group compared to the control group (p=0.000) and pretest (p=0.000) showed a significant decrease. Conclusions: Exercise improved glycemic index in obese and overweight men by improving the levels of preptin and adropine. It seems that aerobic exercise can be an effective intervention method to control and prevent the occurrence of metabolic diseases in these people.
{"title":"The Effect of Aerobic Training on Preptin, Adropin and Insulin Resistance in Overweight Men","authors":"Alireza Shiroyeh, Farshad Emami, M. Sanaee, Rasol Tarighi","doi":"10.52547/jarums.20.4.551","DOIUrl":"https://doi.org/10.52547/jarums.20.4.551","url":null,"abstract":"Background & objectives: Preptin and adropine are peptide hormones that play an important role in the controlling of obesity by regulation of carbohydrate metabolism. The purpose of the present study was to investigate the effect of aerobic training on preptin, adropine and insulin resistance in men with overweight. Methods: In this clinical trial study, 18 overweight and obese men (age 58.39±3.92, body mass index 28.75±1.23) were selected and randomly divided into two groups (control and exercise). Exercise group participated in an aerobic exercise program for eight weeks, five sessions per week (with an intensity of 65 to 85% of maximum heart rate, 40 minutes). Two days before and after the protocol, fasting blood samples were taken. Preptin and adropine were measured by ELISA. Data were tested using independent t-test and ANCOVA at a significance level of p<0.05. Results: The level of preptin in the experimental group was significantly reduced compared to the control group (p=0.001) and the pretest (p=0.000). Also, the adropine level in the experimental group increased significantly compared to the control group (p=0.000) and the pretest (p=0.000). Also, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) values in the exercise group compared to the control group (p=0.000) and pretest (p=0.000) showed a significant decrease. Conclusions: Exercise improved glycemic index in obese and overweight men by improving the levels of preptin and adropine. It seems that aerobic exercise can be an effective intervention method to control and prevent the occurrence of metabolic diseases in these people.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45175464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.52547/jarums.20.4.505
S. Seidi, M. Tavassoli, F. Malekifard
Background & objectives: Fleas are clinically important parasites for affecting human health. These insects are carriers of some pathogens such as Yersinia pestis, Rickettsia typhi, Q fever, Tularemia and Bartonella henselae which are infectious for humans and animals. The aim of this cross–sectional study was to detection of Rickettsia, Bartonella and Wolbachia pathogens in infected Ctenocephalides canis and Pulex irritans using a molecular method in the West and Northwest of Iran. Methods: The present study is a descriptive, cross-sectional study (prevalence rate=10%, confidence level=95%, error rate=5%) performed on samples collected from five provinces including Kermanshah, Kurdistan, Azerbaijan Western, Lorestan and Hamedan for 13 months from May 2018 to June 2019. In this study, samples were collected by optical trap, human prey and direct isolation of the sample from the host and identified in the parasitology laboratory using valid diagnostic keys. The prevalence of Rickettsia, Bartonella and Wolbachia in the collected samples was detected using polymerase chain reaction (PCR). Amplification and sequencing of gltA, pap31 and 16SrRNA genes were used for molecular diagnosis of Rickettsia, Bartonella, and Wolbachia respectively. Results: The collected samples included 918 (47.39%) fleas of C.canis and 1019 (52.60%) fleas of P.irritant. The PCR products of each gene were subject to sequencing. In this study, 12.9%, 5.21% and 5.21% of fleas were positive for Wolbachia, Rickettsia and Bartonella, respectively . Conclusion: Bartonella, Rickettsia and Welbachia are vector borne infectious agent. Due to their high pathogenicity and easily transmission among insect and human, monitoring of insects is essential for the controlling of the infection and preserving the public health in endemic area.
{"title":"Cross-sectional study of Bartonella, Rickettsia and Wolbachia by molecular method in Fleas Ctenocephalides canis and Pulex irritans from the West and Northwest of Iran","authors":"S. Seidi, M. Tavassoli, F. Malekifard","doi":"10.52547/jarums.20.4.505","DOIUrl":"https://doi.org/10.52547/jarums.20.4.505","url":null,"abstract":"Background & objectives: Fleas are clinically important parasites for affecting human health. These insects are carriers of some pathogens such as Yersinia pestis, Rickettsia typhi, Q fever, Tularemia and Bartonella henselae which are infectious for humans and animals. The aim of this cross–sectional study was to detection of Rickettsia, Bartonella and Wolbachia pathogens in infected Ctenocephalides canis and Pulex irritans using a molecular method in the West and Northwest of Iran. Methods: The present study is a descriptive, cross-sectional study (prevalence rate=10%, confidence level=95%, error rate=5%) performed on samples collected from five provinces including Kermanshah, Kurdistan, Azerbaijan Western, Lorestan and Hamedan for 13 months from May 2018 to June 2019. In this study, samples were collected by optical trap, human prey and direct isolation of the sample from the host and identified in the parasitology laboratory using valid diagnostic keys. The prevalence of Rickettsia, Bartonella and Wolbachia in the collected samples was detected using polymerase chain reaction (PCR). Amplification and sequencing of gltA, pap31 and 16SrRNA genes were used for molecular diagnosis of Rickettsia, Bartonella, and Wolbachia respectively. Results: The collected samples included 918 (47.39%) fleas of C.canis and 1019 (52.60%) fleas of P.irritant. The PCR products of each gene were subject to sequencing. In this study, 12.9%, 5.21% and 5.21% of fleas were positive for Wolbachia, Rickettsia and Bartonella, respectively . Conclusion: Bartonella, Rickettsia and Welbachia are vector borne infectious agent. Due to their high pathogenicity and easily transmission among insect and human, monitoring of insects is essential for the controlling of the infection and preserving the public health in endemic area.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42987090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.52547/jarums.20.4.485
M. Zeraati, B. Mosaferi
Background & objectives: Epilepsy is one of the most common problems in the health system, of which some cases are resistant to treatment. Recently, environmental enrichment has shown beneficial results in the recovery of some cases of epilepsy. Methods: Male mice were reared in an enriched or normal medium during their growth period. To induce seizures, at adult age, each group was divided into two subgroups, which one of them received pentylenetetrazole eleven times, with two days interval. Results: The enriched environment greatly reduced seizure behaviors and prevented the occurrence of anxiety-like behavior and cognitive disorders. It also prevented an increase in the inflammatory cytokine of TNF-α in the hippocampus . Conclusion: Therefore, a suitable growth environment in childhood and adolescence can be useful in preventing seizure disorders in adulthood.
{"title":"Enriched Environment Protects Against Seizures, and Associated Anxiety and Cognitive Impairment in Mouse","authors":"M. Zeraati, B. Mosaferi","doi":"10.52547/jarums.20.4.485","DOIUrl":"https://doi.org/10.52547/jarums.20.4.485","url":null,"abstract":"Background & objectives: Epilepsy is one of the most common problems in the health system, of which some cases are resistant to treatment. Recently, environmental enrichment has shown beneficial results in the recovery of some cases of epilepsy. Methods: Male mice were reared in an enriched or normal medium during their growth period. To induce seizures, at adult age, each group was divided into two subgroups, which one of them received pentylenetetrazole eleven times, with two days interval. Results: The enriched environment greatly reduced seizure behaviors and prevented the occurrence of anxiety-like behavior and cognitive disorders. It also prevented an increase in the inflammatory cytokine of TNF-α in the hippocampus . Conclusion: Therefore, a suitable growth environment in childhood and adolescence can be useful in preventing seizure disorders in adulthood.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44662972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.52547/jarums.20.4.439
Neda Omidian, Houshang Najafi
Background & objectives: One of the most important causes of acute kidney injury is ischemia-reperfusion (IR). Some studies have shown that adenosine A1 receptor inhibition have protective effects against Ischemia–reperfusion induced renal injuries, while other studies have demonstrated the opposite. The aim of the present study was to review the methodology of these studies to reach a final conclusion about the effects of adenosine A1 receptor on ischemia-reperfusion-induced renal injuries. Methods: Data base motors including Scopus, PubMed, Google Scholar, Science Direct and Embase were searched. The terms and keywords used included ischemia-reperfusion, acute kidney injury, acute renal failure, A1 adenosine receptor and their combination. Results: Increased adenosine levels following renal Ischemia-reperfusion cause vasoconstriction in afferent arteriole and vasodilatation in efferent arteriole through A1 adenosine receptor activation, which in turn reduces glomerular filtration rate (GFR). Inhibition of A1 adenosine receptor leads to short-term correction of renal functional parameters following renal Ischemia-reperfusion, by increasing renal blood flow and thus improving GFR. But this increase in GFR exacerbates kidney damages through the kidneys workload enhancement, which will show up in the next few hours. Conclusions: Although selective inhibition of A1 adenosine receptor in the short term improves renal function parameters, but exacerbates renal damages in the following hours. Therefore, adenosine A1 receptor stimulation has protective effects against IR-induced kidney injury.
{"title":"Pathophysiology of A1 Adenosine Receptor Inhibition in Acute Kidney Injury Induced by Ischemia-Reperfusion: a Review Study","authors":"Neda Omidian, Houshang Najafi","doi":"10.52547/jarums.20.4.439","DOIUrl":"https://doi.org/10.52547/jarums.20.4.439","url":null,"abstract":"Background & objectives: One of the most important causes of acute kidney injury is ischemia-reperfusion (IR). Some studies have shown that adenosine A1 receptor inhibition have protective effects against Ischemia–reperfusion induced renal injuries, while other studies have demonstrated the opposite. The aim of the present study was to review the methodology of these studies to reach a final conclusion about the effects of adenosine A1 receptor on ischemia-reperfusion-induced renal injuries. Methods: Data base motors including Scopus, PubMed, Google Scholar, Science Direct and Embase were searched. The terms and keywords used included ischemia-reperfusion, acute kidney injury, acute renal failure, A1 adenosine receptor and their combination. Results: Increased adenosine levels following renal Ischemia-reperfusion cause vasoconstriction in afferent arteriole and vasodilatation in efferent arteriole through A1 adenosine receptor activation, which in turn reduces glomerular filtration rate (GFR). Inhibition of A1 adenosine receptor leads to short-term correction of renal functional parameters following renal Ischemia-reperfusion, by increasing renal blood flow and thus improving GFR. But this increase in GFR exacerbates kidney damages through the kidneys workload enhancement, which will show up in the next few hours. Conclusions: Although selective inhibition of A1 adenosine receptor in the short term improves renal function parameters, but exacerbates renal damages in the following hours. Therefore, adenosine A1 receptor stimulation has protective effects against IR-induced kidney injury.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47239480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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