Pub Date : 2022-07-01DOI: 10.52547/jarums.22.2.103
Aida Nahumi, M. Peymani, Hussein A. Ghanimi, A. Asadi, A. Abdolmaleki
{"title":"RNA Editing and Its Application in Medicine","authors":"Aida Nahumi, M. Peymani, Hussein A. Ghanimi, A. Asadi, A. Abdolmaleki","doi":"10.52547/jarums.22.2.103","DOIUrl":"https://doi.org/10.52547/jarums.22.2.103","url":null,"abstract":"","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47527038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.52547/jarums.22.2.204
P. Habibi, H. Yousefi, M. Khazaei, M. Zarei, I. Salehi, Reza Jamali Delfan, Simin Afshar
{"title":"Evaluation of Analgesic, Anti-inflammatory and Antioxidant Effects of Genistein and Swimming in Ovariectomized Rats","authors":"P. Habibi, H. Yousefi, M. Khazaei, M. Zarei, I. Salehi, Reza Jamali Delfan, Simin Afshar","doi":"10.52547/jarums.22.2.204","DOIUrl":"https://doi.org/10.52547/jarums.22.2.204","url":null,"abstract":"","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41544962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.52547/jarums.22.2.186
Hamideh Montazery Taleghani, N. Shakeri, K. Ebrahim, R. Soori, M. Gholami
{"title":"The Effect of Endurance and Resistance Training on Apoptosis Activity and Collagen Deposition in Heart Tissue of Diabetic Rats","authors":"Hamideh Montazery Taleghani, N. Shakeri, K. Ebrahim, R. Soori, M. Gholami","doi":"10.52547/jarums.22.2.186","DOIUrl":"https://doi.org/10.52547/jarums.22.2.186","url":null,"abstract":"","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46264694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.52547/jarums.22.2.168
B. Shademan, M. Nikanfar, J. Rezaei, M. Hassanpour, Mohammad Nouri, Alireza Nourazarian
{"title":"Investigating the Expression level of miRNA-21, miRNA-155, miRNA-182, and miRNA-437 along with Inflammatory Markers in Cerebrospinal Fluid of Patients with Multiple Sclerosis","authors":"B. Shademan, M. Nikanfar, J. Rezaei, M. Hassanpour, Mohammad Nouri, Alireza Nourazarian","doi":"10.52547/jarums.22.2.168","DOIUrl":"https://doi.org/10.52547/jarums.22.2.168","url":null,"abstract":"","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49574175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & objectives : The 2019 coronavirus pandemic is a major threat to global public health due to unprecedented individual and social fear and anxiety and it puts significant stress on health-related quality of life and challenges health care professionals, including dentists, with increasing patient burdens, unprecedented disruptions in normal life and The high risk of being exposed to the disease has put them in stressful situations and therefore they are more exposed to stressful situations that can affect their quality of life. Therefore, this study was conducted with the aim of investigating the level of perceived stress and the quality of life of the students and professors of Ardabil Dental School in the face of the outbreak of the 2019 coronavirus disease in 2021 and the relationship between these two variables with the demographic characteristics of the participants. Methods: To measure the level of perceived stress, Cohen's Perceived Stress Questionnaire was used, and to measure the quality of life, the World Health Organization Quality of Life Standard Questionnaire-Abbreviated (WHOQOL-BREF) was used. The statistical population in this study is all dental professors and dental students of the Faculty of Dentistry of Ardabil University of Medical Sciences. A significance level of less than 0.05 was considered. Results: From the statistical population of this study, a total of 227 people including 33 professors and 194 students participated in the study. There was no significant relationship between demographic variables and perceived stress variables and quality of life. Perceived stress and quality of life were higher for professors than for students during the pandemic. There was a direct relationship between perceived stress variables and quality of life in both groups. The level of perceived stress in both groups was lower than the optimal level and the quality of life in both groups was higher than the optimal level. Conclusion: Students and professors of Ardabil Faculty of Dentistry experienced moderate stress during the Covid-19 epidemic and had a good quality of life. By comparing between the two groups of participants, professors had more perceived stress.
{"title":"Assessment of the Level of Perceived Stress and Quality of Life in Students and Professors of Ardabil Dental School during the Covid-19 Epidemic in the Academic Year 2020-2021","authors":"Ayda Naderi pour, Soheila Derisavy Jorfian","doi":"10.52547/jarums.22.1.28","DOIUrl":"https://doi.org/10.52547/jarums.22.1.28","url":null,"abstract":"Background & objectives : The 2019 coronavirus pandemic is a major threat to global public health due to unprecedented individual and social fear and anxiety and it puts significant stress on health-related quality of life and challenges health care professionals, including dentists, with increasing patient burdens, unprecedented disruptions in normal life and The high risk of being exposed to the disease has put them in stressful situations and therefore they are more exposed to stressful situations that can affect their quality of life. Therefore, this study was conducted with the aim of investigating the level of perceived stress and the quality of life of the students and professors of Ardabil Dental School in the face of the outbreak of the 2019 coronavirus disease in 2021 and the relationship between these two variables with the demographic characteristics of the participants. Methods: To measure the level of perceived stress, Cohen's Perceived Stress Questionnaire was used, and to measure the quality of life, the World Health Organization Quality of Life Standard Questionnaire-Abbreviated (WHOQOL-BREF) was used. The statistical population in this study is all dental professors and dental students of the Faculty of Dentistry of Ardabil University of Medical Sciences. A significance level of less than 0.05 was considered. Results: From the statistical population of this study, a total of 227 people including 33 professors and 194 students participated in the study. There was no significant relationship between demographic variables and perceived stress variables and quality of life. Perceived stress and quality of life were higher for professors than for students during the pandemic. There was a direct relationship between perceived stress variables and quality of life in both groups. The level of perceived stress in both groups was lower than the optimal level and the quality of life in both groups was higher than the optimal level. Conclusion: Students and professors of Ardabil Faculty of Dentistry experienced moderate stress during the Covid-19 epidemic and had a good quality of life. By comparing between the two groups of participants, professors had more perceived stress.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42697598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & objectives : Low immunogenicity and targeted migration of mesenchymal stem cells to inflammatory sites have introduced these cells as the best vehicle for the delivery of gene or therapeutic products. Lentiviral vectors can be used as an efficient vehicle for inserting ectopic genes into stem cells. Therefore, the evaluation of the effect of lentiviral vectors on the identity, behavior and functional characteristics of the stem cells can show that vectors are safe tools in cell manipulation and gene therapy. Methods : At first, three vectors of lentivirus were added to HEK-293T cells using calcium phosphate method. After confirming the expression of GFP protein in more than 80% of HEK-293T cells, viral supernatant was collected and concentrated. Human adipose-derived mesenchymal stem cells (hASCs) were transduced with condensed viruses. After the elimination of the non-transduced cells by puromycin, transduced hASCs were evaluated for immunophenotyping and differentiation to adipocyte and osteocyte. Behavioral characteristics such as viability, migration and invasion were analyzed using MTT and transwell methods, respectively. Results : In the current study, there was no significant difference in the expression of CD29, CD34, CD73 and differentiation to adipocyte and osteocyte in the test group when compared to the control group. Moreover, there was no significant difference between two study groups in the behavioral characteristics such as proliferation, invasion and migration. Discussion : The findings of this study declare that lentiviral vectors do not have adverse effects on the identity and functional characteristics of stem cells. Therefore, they can be used in gene manipulation of the target cell.
{"title":"The Study of Differential and Behavioral Characteristics of Manipulated Human Adipose-Derived Mesenchymal Stem Cells by Lentiviral Vector","authors":"Katayoun Bahman Soufiani","doi":"10.52547/jarums.22.1.72","DOIUrl":"https://doi.org/10.52547/jarums.22.1.72","url":null,"abstract":"Background & objectives : Low immunogenicity and targeted migration of mesenchymal stem cells to inflammatory sites have introduced these cells as the best vehicle for the delivery of gene or therapeutic products. Lentiviral vectors can be used as an efficient vehicle for inserting ectopic genes into stem cells. Therefore, the evaluation of the effect of lentiviral vectors on the identity, behavior and functional characteristics of the stem cells can show that vectors are safe tools in cell manipulation and gene therapy. Methods : At first, three vectors of lentivirus were added to HEK-293T cells using calcium phosphate method. After confirming the expression of GFP protein in more than 80% of HEK-293T cells, viral supernatant was collected and concentrated. Human adipose-derived mesenchymal stem cells (hASCs) were transduced with condensed viruses. After the elimination of the non-transduced cells by puromycin, transduced hASCs were evaluated for immunophenotyping and differentiation to adipocyte and osteocyte. Behavioral characteristics such as viability, migration and invasion were analyzed using MTT and transwell methods, respectively. Results : In the current study, there was no significant difference in the expression of CD29, CD34, CD73 and differentiation to adipocyte and osteocyte in the test group when compared to the control group. Moreover, there was no significant difference between two study groups in the behavioral characteristics such as proliferation, invasion and migration. Discussion : The findings of this study declare that lentiviral vectors do not have adverse effects on the identity and functional characteristics of stem cells. Therefore, they can be used in gene manipulation of the target cell.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49195397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Somayeh Zeynizadeh Jeddi, M. Yousefian, Hamed Razmjoo Jelodar
{"title":"Chest CT Scan Involvement Patterns in Patients with Suspected Covid-19 Symptoms","authors":"Somayeh Zeynizadeh Jeddi, M. Yousefian, Hamed Razmjoo Jelodar","doi":"10.52547/jarums.22.1.63","DOIUrl":"https://doi.org/10.52547/jarums.22.1.63","url":null,"abstract":"","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70687975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & objectives: Urinary tract infection is still one of the most common diseases that affect pregnant women. The aim of this study was to determine the impact of sexual hygiene behaviors on urinary tract infection in pregnant women. Methods: A case-control study was conducted on 100 pregnant women with urinary tract infection (case group) and 150 pregnant women without urinary tract infection (control group) in health centers of Ardabil city in 2020. Purposive sampling was done in 6-10 weeks of pregnancy. The information was collected through a researcher-made questionnaire. SPSS 21 software was used for statistical analysis of data. The odds ratio (OR) of infection in both groups was estimated by logistic regression. Results: Sexual health behaviors in the majority of women of the case group (47%) were average (with score of 50.1-66), but in the majority of the control group (49.33%) were good (with score of 66.1-84) ( p <0.001). Sexual intercourse 3 or more times in a week in the last 30 days was significantly higher in the case group than in the control group ( p =0.001). Spouse bathing before sexual intercourse was less in women in the case group than the control group ( p =0.022). Statistically significant differences were observed in Pre-coital voiding ( p =0.04), Post coital voiding ( p =0.02) and post-coital bathing ( p =0.03) in the two groups. Conclusion: Sexual hygiene behaviors play an important role in preventing or contracting urinary tract infections. Therefore, training and improving hygiene behaviors in women and their spouses is an effective step in reducing urinary tract infections.
{"title":"Impact of Sexual Hygiene Behaviors on Urinary Tract Infection in Pregnant Women","authors":"A. Mardi, Golnaz Alizadeh","doi":"10.52547/jarums.22.1.18","DOIUrl":"https://doi.org/10.52547/jarums.22.1.18","url":null,"abstract":"Background & objectives: Urinary tract infection is still one of the most common diseases that affect pregnant women. The aim of this study was to determine the impact of sexual hygiene behaviors on urinary tract infection in pregnant women. Methods: A case-control study was conducted on 100 pregnant women with urinary tract infection (case group) and 150 pregnant women without urinary tract infection (control group) in health centers of Ardabil city in 2020. Purposive sampling was done in 6-10 weeks of pregnancy. The information was collected through a researcher-made questionnaire. SPSS 21 software was used for statistical analysis of data. The odds ratio (OR) of infection in both groups was estimated by logistic regression. Results: Sexual health behaviors in the majority of women of the case group (47%) were average (with score of 50.1-66), but in the majority of the control group (49.33%) were good (with score of 66.1-84) ( p <0.001). Sexual intercourse 3 or more times in a week in the last 30 days was significantly higher in the case group than in the control group ( p =0.001). Spouse bathing before sexual intercourse was less in women in the case group than the control group ( p =0.022). Statistically significant differences were observed in Pre-coital voiding ( p =0.04), Post coital voiding ( p =0.02) and post-coital bathing ( p =0.03) in the two groups. Conclusion: Sexual hygiene behaviors play an important role in preventing or contracting urinary tract infections. Therefore, training and improving hygiene behaviors in women and their spouses is an effective step in reducing urinary tract infections.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41494827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Asadi-Samani, N. Jamali, Javad Saffari-Chaleshtori, Korosh Ashrafi-Dehkordi
Background & objectives: Cyclin-dependent kinase 2 (CDK-2) is a serine/threonine protein kinase with regulatory activity in the cell cycle. Inhibitors of this protein are the treatment of choice for a variety of cancers by stopping the cell cycle. In this in silico study, the effects of docking and molecular dynamics of Abemaciclib, Hymenialdisine
{"title":"Evaluating the Effects of Molecular Dynamic And Docking of Abemaciclib, Hymenialdisine, and Indirubin on CDK-2 Inhibition by Simulation Study","authors":"M. Asadi-Samani, N. Jamali, Javad Saffari-Chaleshtori, Korosh Ashrafi-Dehkordi","doi":"10.52547/jarums.22.1.39","DOIUrl":"https://doi.org/10.52547/jarums.22.1.39","url":null,"abstract":"Background & objectives: Cyclin-dependent kinase 2 (CDK-2) is a serine/threonine protein kinase with regulatory activity in the cell cycle. Inhibitors of this protein are the treatment of choice for a variety of cancers by stopping the cell cycle. In this in silico study, the effects of docking and molecular dynamics of Abemaciclib, Hymenialdisine","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45512216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & objectives: Obesity and a high-fat diet (HFD) lead to metabolic disorders in the liver by affecting the signaling pathways of fat and glucose metabolism. Exercise and dietary habits are of special interest to prevent and counteract obesity and its associated metabolic disorders. Also, Capsaicin ameliorates diet-induced obesity in rodents and humans. The aim of the present study was to examine the effect of aerobic exercise and capsaicin on the gene expression level of AMP-activated protein kinase (AMPK) and protein kinase B (Akt) in the liver of HFD rats. Methods: in this experimental study, 40 male Wistar rats were fed a normal diet (ND, n=8) or high-fat diet (HFD) (n=32) for 8 weeks. After 8 weeks, all rats were divided into 5 groups: normal diet (ND), high-fat diet (HFD), high-fat diet-training (HFDT), high-fat diet-capsaicin (HFDCap), high-fat diet-training-capsaicin (HFDTCap). Training groups have performed a moderate- intensity aerobic running program (60-50% VO2max, at 15-25 m/min, 30-60 min/day, and 5 days/week) on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/day) was administered orally, by gavage, once a day. Results: Induction of diabetes was associated with decreased AMPK expression ( p =0.0001) and increased Akt ( p =0.0001). The results showed that training and capsaicin significantly increased AMPK expression ( p =0.032 and p =0.045, respectively) and decreased Akt expression ( p =0.045 and p =0.049, respectively) in HFD rat hepatocytes. Also, the interaction of training and capsaicin had a significant effect on the expression of AMPK ( p =0.017) and Akt ( p =0.0001). Conclusion: The results showed that HFD impaired hepatocyte function and that aerobic exercise and capsaicin increased lipogenesis with increasing AMPK and decreasing Akt expression. However, the interaction effect of training with capsaicin was greater.
{"title":"Synergistic Effects of the Aerobic Training and Capsaicin on the Expression level of AMP-Activated Protein Kinase and Protein Kinase B Gene of Liver Tissue in Rat Fed a High-Fat Diet","authors":"Ghasem Torabi Palat Kaleh, A. Sadeghi, Ahmad Abdi","doi":"10.52547/jarums.22.1.50","DOIUrl":"https://doi.org/10.52547/jarums.22.1.50","url":null,"abstract":"Background & objectives: Obesity and a high-fat diet (HFD) lead to metabolic disorders in the liver by affecting the signaling pathways of fat and glucose metabolism. Exercise and dietary habits are of special interest to prevent and counteract obesity and its associated metabolic disorders. Also, Capsaicin ameliorates diet-induced obesity in rodents and humans. The aim of the present study was to examine the effect of aerobic exercise and capsaicin on the gene expression level of AMP-activated protein kinase (AMPK) and protein kinase B (Akt) in the liver of HFD rats. Methods: in this experimental study, 40 male Wistar rats were fed a normal diet (ND, n=8) or high-fat diet (HFD) (n=32) for 8 weeks. After 8 weeks, all rats were divided into 5 groups: normal diet (ND), high-fat diet (HFD), high-fat diet-training (HFDT), high-fat diet-capsaicin (HFDCap), high-fat diet-training-capsaicin (HFDTCap). Training groups have performed a moderate- intensity aerobic running program (60-50% VO2max, at 15-25 m/min, 30-60 min/day, and 5 days/week) on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/day) was administered orally, by gavage, once a day. Results: Induction of diabetes was associated with decreased AMPK expression ( p =0.0001) and increased Akt ( p =0.0001). The results showed that training and capsaicin significantly increased AMPK expression ( p =0.032 and p =0.045, respectively) and decreased Akt expression ( p =0.045 and p =0.049, respectively) in HFD rat hepatocytes. Also, the interaction of training and capsaicin had a significant effect on the expression of AMPK ( p =0.017) and Akt ( p =0.0001). Conclusion: The results showed that HFD impaired hepatocyte function and that aerobic exercise and capsaicin increased lipogenesis with increasing AMPK and decreasing Akt expression. However, the interaction effect of training with capsaicin was greater.","PeriodicalId":30758,"journal":{"name":"Journal of Ardabil University of Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42863027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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