Aims: This study investigated the relationship between Naples prognostic score (NPS) and 1-year poor clinical outcomes in patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI). Methods: The study included 121 patients who had NSTEMI and received successful PCI treatment. The researchers calculated NPS using the neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, serum albumin level, and total cholesterol. The patients were divided into two groups based on their NPS scores: those with scores of 0.1 and 2 and those with scores of 3 and 4. The study compared the occurrence of major cardiovascular events (MACE) such as 1-year all-cause mortality, 1-year nonfatal recurrent MI, and stroke between the two groups. Results: Patients with high NPS scores were observed to have significantly higher all-cause mortality than those with low NPS scores (23.9% vs. 9.3%, p=0.029). When the MACEs of the patients were compared, significantly higher MACE was observed in the high NPS group (39.1% vs. 18.7%, p=0.013). In multivariate logistic regression analysis, creatinine (OR:4,914, CI 95%: 1.310-18,433, p=0.018) and NPS 3-4 (OR:2.565, CI 95%: 1.093-6.017, p=0.030) were independent predictors of MACE. Conclusion: Composite MACEs of non-fatal recurrent MI, cerebrovascular accident, and all-cause death were higher at one year in patients with high NPS who underwent successful percutaneous intervention. High NPS is an indicator of MACE.
{"title":"The new score predicts 1-year poor outcome in patients with successful percutaneous coronary intervention: Naples prognostic score","authors":"Alkame Akgümüş, A. Balun","doi":"10.38053/acmj.1342844","DOIUrl":"https://doi.org/10.38053/acmj.1342844","url":null,"abstract":"Aims: This study investigated the relationship between Naples prognostic score (NPS) and 1-year poor clinical outcomes in patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI). Methods: The study included 121 patients who had NSTEMI and received successful PCI treatment. The researchers calculated NPS using the neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, serum albumin level, and total cholesterol. The patients were divided into two groups based on their NPS scores: those with scores of 0.1 and 2 and those with scores of 3 and 4. The study compared the occurrence of major cardiovascular events (MACE) such as 1-year all-cause mortality, 1-year nonfatal recurrent MI, and stroke between the two groups. Results: Patients with high NPS scores were observed to have significantly higher all-cause mortality than those with low NPS scores (23.9% vs. 9.3%, p=0.029). When the MACEs of the patients were compared, significantly higher MACE was observed in the high NPS group (39.1% vs. 18.7%, p=0.013). In multivariate logistic regression analysis, creatinine (OR:4,914, CI 95%: 1.310-18,433, p=0.018) and NPS 3-4 (OR:2.565, CI 95%: 1.093-6.017, p=0.030) were independent predictors of MACE. Conclusion: Composite MACEs of non-fatal recurrent MI, cerebrovascular accident, and all-cause death were higher at one year in patients with high NPS who underwent successful percutaneous intervention. High NPS is an indicator of MACE.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Breast cancer is the most common type of cancer in women and accounts for a large portion of cancer-related deaths. As in the other types of cancer, the prevention and early diagnosis of breast cancer gain importance day after day. For this purpose, the artificial intelligence-based decision support systems become popular in recent years. In this study, an automatic breast lesion segmentation process is proposed to detect breast lesions in the images taken with magnetic resonance imaging (MRI) protocol. Methods: Two most popular segmentation methods: expectation maximization (EM) and K-means algorithms are used to determine the region of breast lesions. Furthermore, superpixel based fuzzy C-means (SPFCM) algorithm is applied after EM and K-means methods to improve the lesion segmentation performance. Results: The proposed methods are evaluated on the private database constructed by the authors with ethical permission. The performances of the utilized methods are analyzed by comparing the lesion areas determined by a radiologist (ground-truth) and areas that are achieved by automatic segmentation algorithms. Conclusion: Dice coefficient, Jaccard index (JI), and area under curve (AUC) metrics are calculated for performance comparison. According to the simulation results, EM, K-means, EM+SPFCM, and K-means+SPFCM methods provides good segmentation performance on breast MRI database. The best segmentation results are obtained by using EM+SPFCM hybrid method. The results of the EM+SPFCM method are 0,8711, 0,8979, and 0,9981 for JI, Dice, and AUC, respectively.
{"title":"Improving the performance of EM and K-means algorithms for breast lesion segmentation","authors":"Fuldem Mutlu, Sevda Gül","doi":"10.38053/acmj.1361202","DOIUrl":"https://doi.org/10.38053/acmj.1361202","url":null,"abstract":"Aims: Breast cancer is the most common type of cancer in women and accounts for a large portion of cancer-related deaths. As in the other types of cancer, the prevention and early diagnosis of breast cancer gain importance day after day. For this purpose, the artificial intelligence-based decision support systems become popular in recent years. In this study, an automatic breast lesion segmentation process is proposed to detect breast lesions in the images taken with magnetic resonance imaging (MRI) protocol. Methods: Two most popular segmentation methods: expectation maximization (EM) and K-means algorithms are used to determine the region of breast lesions. Furthermore, superpixel based fuzzy C-means (SPFCM) algorithm is applied after EM and K-means methods to improve the lesion segmentation performance. Results: The proposed methods are evaluated on the private database constructed by the authors with ethical permission. The performances of the utilized methods are analyzed by comparing the lesion areas determined by a radiologist (ground-truth) and areas that are achieved by automatic segmentation algorithms. Conclusion: Dice coefficient, Jaccard index (JI), and area under curve (AUC) metrics are calculated for performance comparison. According to the simulation results, EM, K-means, EM+SPFCM, and K-means+SPFCM methods provides good segmentation performance on breast MRI database. The best segmentation results are obtained by using EM+SPFCM hybrid method. The results of the EM+SPFCM method are 0,8711, 0,8979, and 0,9981 for JI, Dice, and AUC, respectively.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Mesenchymal stem cells (MSCs) are the apple of the eye of cancer studies. It was indicated that the secreted factors, especially released by MSCs, have tumoral or anti-tumoral effects on tumor progression. MSCs obtained from different sources show different anti-tumoral effects, while MSCs originating from the same source also show different tumoral effects in different cancer cells. Here, we investigated the anti-tumor effects of soluble factors secreted from palatine tonsil MSCs (TMSC) as a new source of MSC on human lung carcinoma (A549) and pancreatic cancer (PANC-1) cell lines. Methods: Conditioned medium (CM) was obtained from TMSCs isolated from palatine tonsil tissue, and the cytotoxic effect of CM on the growth of A549 and PANC-1 in a dose-dependent manner was demonstrated by MTT analysis. In addition, the function of CM treatment on the cell cycle status of cancer cells and the apoptosis process were investigated through cell cycle analysis with propidium iodide (PI) and Annexin-V/PI detection method by flow cytometry analysis, respectively. Results: We demonstrated that TMSC-CM treatment significantly decreased the viability of A549 and PANC-1 cell lines in a dose-dependent manner post-48 hours. In addition, CM treatment differentially induced the apoptosis on A549 and PANC-1 cells and also, caused G2/M arrest in the cells. Conclusion: In light of these findings, our study is the first to show that TMSC-CM has an anti-tumoral effect by stimulating apoptosis on A549 and PANC-1 cells. These findings reveal that the usage of CM has a cell-free cellular therapeutic potential.
{"title":"Conditioned media of tonsil derived mesenchymal stem cells shows different rates of cytotoxicity on solid cancer cells","authors":"M. Yüce, Esra Albayrak, Çağrı Gümüşkaptan","doi":"10.38053/acmj.1359905","DOIUrl":"https://doi.org/10.38053/acmj.1359905","url":null,"abstract":"Aims: Mesenchymal stem cells (MSCs) are the apple of the eye of cancer studies. It was indicated that the secreted factors, especially released by MSCs, have tumoral or anti-tumoral effects on tumor progression. MSCs obtained from different sources show different anti-tumoral effects, while MSCs originating from the same source also show different tumoral effects in different cancer cells. Here, we investigated the anti-tumor effects of soluble factors secreted from palatine tonsil MSCs (TMSC) as a new source of MSC on human lung carcinoma (A549) and pancreatic cancer (PANC-1) cell lines. Methods: Conditioned medium (CM) was obtained from TMSCs isolated from palatine tonsil tissue, and the cytotoxic effect of CM on the growth of A549 and PANC-1 in a dose-dependent manner was demonstrated by MTT analysis. In addition, the function of CM treatment on the cell cycle status of cancer cells and the apoptosis process were investigated through cell cycle analysis with propidium iodide (PI) and Annexin-V/PI detection method by flow cytometry analysis, respectively. Results: We demonstrated that TMSC-CM treatment significantly decreased the viability of A549 and PANC-1 cell lines in a dose-dependent manner post-48 hours. In addition, CM treatment differentially induced the apoptosis on A549 and PANC-1 cells and also, caused G2/M arrest in the cells. Conclusion: In light of these findings, our study is the first to show that TMSC-CM has an anti-tumoral effect by stimulating apoptosis on A549 and PANC-1 cells. These findings reveal that the usage of CM has a cell-free cellular therapeutic potential.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: The aim of this study is to evaluate the Anti-HCV seroprevalence in patients who underwent cataract surgery and to compare the prevalence with other ophthalmic surgery procedures. Methods: Patients who underwent ophthalmic surgeries between January 2017 and January 2023 and were preoperatively screened for anti-HCV by ELISA test were included in this study. Patients who underwent cataract surgery formed the study group and other patients were compared as the control group. All data were obtained from the database of the institute and were retrospectively evaluated. Results: A total of 15799 cases were included in the study, and 69.9% had cataracts whereas 30.1% had non-cataract surgery. The mean age of the patients was 63.24±16.04 years. The rate of Anti-HCV seropositive patients was 0.48% (n=53) in the cataract surgery group, and 0.42% (n=20) in those who had non-cataract surgery. However, the difference was not statistically significant (p=0.696). The overall rate of Anti-HCV seropositive cases was %0.46. Conclusion: Even though there was no significant difference between the two groups, the Anti-HCV was positive for almost 1 in 200 ophthalmic procedures. We strongly recommend preoperative screening due to the severity of HCV infection and the risk of surgical transmission.
{"title":"Comparison of anti-HCV seroprevalence of patients who underwent cataract surgery and other ophthalmic procedures","authors":"Gökhan Özgür, Esmeray Mutlu Yılmaz","doi":"10.38053/acmj.1346900","DOIUrl":"https://doi.org/10.38053/acmj.1346900","url":null,"abstract":"Aims: The aim of this study is to evaluate the Anti-HCV seroprevalence in patients who underwent cataract surgery and to compare the prevalence with other ophthalmic surgery procedures. Methods: Patients who underwent ophthalmic surgeries between January 2017 and January 2023 and were preoperatively screened for anti-HCV by ELISA test were included in this study. Patients who underwent cataract surgery formed the study group and other patients were compared as the control group. All data were obtained from the database of the institute and were retrospectively evaluated. Results: A total of 15799 cases were included in the study, and 69.9% had cataracts whereas 30.1% had non-cataract surgery. The mean age of the patients was 63.24±16.04 years. The rate of Anti-HCV seropositive patients was 0.48% (n=53) in the cataract surgery group, and 0.42% (n=20) in those who had non-cataract surgery. However, the difference was not statistically significant (p=0.696). The overall rate of Anti-HCV seropositive cases was %0.46. Conclusion: Even though there was no significant difference between the two groups, the Anti-HCV was positive for almost 1 in 200 ophthalmic procedures. We strongly recommend preoperative screening due to the severity of HCV infection and the risk of surgical transmission.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Autonomic dysfunction is a prevalent feature throughout various stages of the disease and can significantly exacerbate the overall impact of the condition. Moreover, it is linked to accelerated disease advances and diminished vitality rates in individuals with Parkinson’s disease (PD). The main goal of this study is to evaluate the prevalence of autonomic symptoms and cognitive findings and investigate their associations with disease-related factors in early-stage PD patients. Methods: A total of 49 individuals diagnosed with PD were enrolled in this study. Disease severity was assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS), and the disease stage was determined through the modified Hoehn & Yahr Rating Scale (mHYRS). By the mH&Y scale, only individuals in the early stages (≤2.5) of the disease were included in this investigation. The evaluation of autonomic symptoms in PD was conducted using the Scales for Outcomes in Parkinson’s Disease for Autonomic Symptoms (SCOPA-AUT) scale. The cognitive functions of the patients were assessed utilizing the Turkish version of the Montreal Cognitive Assessment Scale (MOCA-TR). Results: The study included 44% (n=22) females and 56% (n=27) males as participants. The average age was 61.5±10.1 years. The mean SCOPA-AUT score was 18.9±9.36, with the most prevalent autonomic symptoms related to the gastrointestinal system. A positive correlation was shown with autonomic symptoms and disease stages (p=0.024, r=0.322). However, no significant relationship was found between autonomic symptoms, other disease parameters, and cognition. We observed a notable inverse correlation between the disease stage and cognitive status (p=0.003, r=-0.417). Conclusion: Our study concluded that autonomic dysfunctions manifest from the early stages of Parkinson’s disease and can intensify as the disease progresses. Identifying and addressing these dysfunctions at an early stage would play a pivotal role in lessening the overall impact of the disease.
{"title":"Autonomic symptoms in early-stage Parkinson’s patients and their relationship with cognition and disease parameters","authors":"E. Kobak Tur, E. Gözke","doi":"10.38053/acmj.1355855","DOIUrl":"https://doi.org/10.38053/acmj.1355855","url":null,"abstract":"Aims: Autonomic dysfunction is a prevalent feature throughout various stages of the disease and can significantly exacerbate the overall impact of the condition. Moreover, it is linked to accelerated disease advances and diminished vitality rates in individuals with Parkinson’s disease (PD). The main goal of this study is to evaluate the prevalence of autonomic symptoms and cognitive findings and investigate their associations with disease-related factors in early-stage PD patients. Methods: A total of 49 individuals diagnosed with PD were enrolled in this study. Disease severity was assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS), and the disease stage was determined through the modified Hoehn & Yahr Rating Scale (mHYRS). By the mH&Y scale, only individuals in the early stages (≤2.5) of the disease were included in this investigation. The evaluation of autonomic symptoms in PD was conducted using the Scales for Outcomes in Parkinson’s Disease for Autonomic Symptoms (SCOPA-AUT) scale. The cognitive functions of the patients were assessed utilizing the Turkish version of the Montreal Cognitive Assessment Scale (MOCA-TR). Results: The study included 44% (n=22) females and 56% (n=27) males as participants. The average age was 61.5±10.1 years. The mean SCOPA-AUT score was 18.9±9.36, with the most prevalent autonomic symptoms related to the gastrointestinal system. A positive correlation was shown with autonomic symptoms and disease stages (p=0.024, r=0.322). However, no significant relationship was found between autonomic symptoms, other disease parameters, and cognition. We observed a notable inverse correlation between the disease stage and cognitive status (p=0.003, r=-0.417). Conclusion: Our study concluded that autonomic dysfunctions manifest from the early stages of Parkinson’s disease and can intensify as the disease progresses. Identifying and addressing these dysfunctions at an early stage would play a pivotal role in lessening the overall impact of the disease.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gökhan Ergün, Eyüp Özkan, Erkan Demirci, Ferhat Gökay, Y. Yilmaz
Aims: Primary hyperparathyroidism (PHPT) is a clinical entity characterized by hypercalcemia caused by excessive parathyroid hormone (PTH) secretion from the parathyroid gland and is the most common cause of hypercalcemia in outpatient clinics. Atrial fibrillation (AF) is a common arrhythmia encountered in cardiology practice, the prevalence of which increases with concomitant heart disease and age. P-wave peak time (PWPT) is the time from the onset of the p-wave to its peak and is a recently defined electrocardiographic (ECG) parameter. Recently, studies on the relationship between PWPT and cardiovascular events have been published. In this study, we aimed to evaluate the risk of AF in PHPT patients by detecting PWPT, a new ECG parameter. Methods: The study included 21 PHPT patients and 20 healthy subjects as a control group. The groups were compared in terms of demographic characteristics, laboratory findings, echocardiography, and ECG findings. D2 and V1 leads were used for PWPT, as recommended in the literature. Results: When the patient group was compared with the control group, no difference was detected in terms of demographic characteristics and laboratory findings. When compared with the control group, patients with PHPT had significantly longer PWPT (PWPTV1 56.07 msec ± 8.33 s vs. 50.25 msec ± 7.00 s p
{"title":"Evaluation of the risk of developing atrial fibrillation with new electrocardiographic parameters in patients with primary hyperparathyroidism","authors":"Gökhan Ergün, Eyüp Özkan, Erkan Demirci, Ferhat Gökay, Y. Yilmaz","doi":"10.38053/acmj.1344172","DOIUrl":"https://doi.org/10.38053/acmj.1344172","url":null,"abstract":"Aims: Primary hyperparathyroidism (PHPT) is a clinical entity characterized by hypercalcemia caused by excessive parathyroid hormone (PTH) secretion from the parathyroid gland and is the most common cause of hypercalcemia in outpatient clinics. Atrial fibrillation (AF) is a common arrhythmia encountered in cardiology practice, the prevalence of which increases with concomitant heart disease and age. P-wave peak time (PWPT) is the time from the onset of the p-wave to its peak and is a recently defined electrocardiographic (ECG) parameter. Recently, studies on the relationship between PWPT and cardiovascular events have been published. In this study, we aimed to evaluate the risk of AF in PHPT patients by detecting PWPT, a new ECG parameter. Methods: The study included 21 PHPT patients and 20 healthy subjects as a control group. The groups were compared in terms of demographic characteristics, laboratory findings, echocardiography, and ECG findings. D2 and V1 leads were used for PWPT, as recommended in the literature. Results: When the patient group was compared with the control group, no difference was detected in terms of demographic characteristics and laboratory findings. When compared with the control group, patients with PHPT had significantly longer PWPT (PWPTV1 56.07 msec ± 8.33 s vs. 50.25 msec ± 7.00 s p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: This study aimed to investigate whether the concentrations of Galactin-3 (G-3), Copeptin (CP) and Retina Binding Protein-4 (RBP-4) are affected in the vitreous humor of patients with diabetic retinopathy (DR). Methods: Thirty-six patients with diabetes mellitus (DM) were included in the study, consisting of 10 patients without DR and 26 patients with proliferative diabetic retinopathy (PDR). The control group comprised 15 patients who underwent vitrectomy for epiretinal membrane and macular hole surgeries. Vitreous CP, G-3, and RBP-4 concentrations were examined using the enzyme-linked immunosorbent assay (ELISA) method. The groups were compared internally Results: We did not observe any significant differences in the concentrations of G-3, CP and RBP-4 in the vitreous humor between diabetic patients and the control group (p=0.56, p=0.65 and p=0.11, respectively). When comparing vitreous samples of diabetic subgroups with and without DR findings to the control group, no significant differences were detected (p=0.51, p=0.66, and p=0.19, respectively). Conclusion: Our results indicate that the concentrations of G-3, CP, and RBP-4 in the vitreous humor remain unchanged in both diabetic patients and those with proliferative diabetic retinopathy (DRP).
{"title":"Does vitreous galactin-3, copeptin and retina binding protein-4 concentrations change in diabetic retinopathy?","authors":"Şerife Gülhan Konuk, Raşit Kiliç, Merve Çatak, Alper Güneş, M. Katar","doi":"10.38053/acmj.1341013","DOIUrl":"https://doi.org/10.38053/acmj.1341013","url":null,"abstract":"Aims: This study aimed to investigate whether the concentrations of Galactin-3 (G-3), Copeptin (CP) and Retina Binding Protein-4 (RBP-4) are affected in the vitreous humor of patients with diabetic retinopathy (DR). Methods: Thirty-six patients with diabetes mellitus (DM) were included in the study, consisting of 10 patients without DR and 26 patients with proliferative diabetic retinopathy (PDR). The control group comprised 15 patients who underwent vitrectomy for epiretinal membrane and macular hole surgeries. Vitreous CP, G-3, and RBP-4 concentrations were examined using the enzyme-linked immunosorbent assay (ELISA) method. The groups were compared internally Results: We did not observe any significant differences in the concentrations of G-3, CP and RBP-4 in the vitreous humor between diabetic patients and the control group (p=0.56, p=0.65 and p=0.11, respectively). When comparing vitreous samples of diabetic subgroups with and without DR findings to the control group, no significant differences were detected (p=0.51, p=0.66, and p=0.19, respectively). Conclusion: Our results indicate that the concentrations of G-3, CP, and RBP-4 in the vitreous humor remain unchanged in both diabetic patients and those with proliferative diabetic retinopathy (DRP).","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Vaccination is of great importance due to the increased risk of infection as a result of changes in the immune system with aging and the weak immune response against these infections. In this study, it was aimed to determine the pneumococcal and influenza vaccination awareness and vaccination rates of individuals aged 65 years and over, to direct the unvaccinated individuals to be vaccinated and to protect them from possible infections and complications. Methods: A questionnaire form was filled in by asking demographic information, awareness of influenza and pneumococcal vaccines and the status of vaccination of individuals aged 65 years and over who applied to the clinic between June and September 2020. Unvaccinated individuals were referred to the vaccination unit. Results: A total of 553 elderly individuals aged 65 years and over, 338 women and 215 men, were included in the study. Among the study participants, the rate of patients with awareness of influenza/pneumococcal vaccine was 48.5%. Although the vaccination awareness rate was higher in males, non-smokers, those with higher education level, those with at least one of the comorbidities such as hypertension, coronary artery disease, hyperlipidemia, chronic renal failure, vaccination rates were lower in patients with these comorbidities and additionally diabetes mellitus. The majority of individuals with awareness were informed by healthcare workers. The rate of vaccination among the individuals participating in the study was 18.4%. Vaccination was higher in individuals with awareness. While 5.3% of those who were not vaccinated were hospitalized for pneumonia, those who were vaccinated did not have pneumonia severe enough to require hospitalization. Conclusion: In order to fight with the increasing vaccine hesitancy in our society, healthcare workers should be educated, the media should be supported, and vaccination should be encouraged in every clinic application.
{"title":"Pneumococcal and influenza vaccine awareness in individuals over 65 years","authors":"Nurhan Sayaca","doi":"10.38053/acmj.1344692","DOIUrl":"https://doi.org/10.38053/acmj.1344692","url":null,"abstract":"Aims: Vaccination is of great importance due to the increased risk of infection as a result of changes in the immune system with aging and the weak immune response against these infections. In this study, it was aimed to determine the pneumococcal and influenza vaccination awareness and vaccination rates of individuals aged 65 years and over, to direct the unvaccinated individuals to be vaccinated and to protect them from possible infections and complications. Methods: A questionnaire form was filled in by asking demographic information, awareness of influenza and pneumococcal vaccines and the status of vaccination of individuals aged 65 years and over who applied to the clinic between June and September 2020. Unvaccinated individuals were referred to the vaccination unit. Results: A total of 553 elderly individuals aged 65 years and over, 338 women and 215 men, were included in the study. Among the study participants, the rate of patients with awareness of influenza/pneumococcal vaccine was 48.5%. Although the vaccination awareness rate was higher in males, non-smokers, those with higher education level, those with at least one of the comorbidities such as hypertension, coronary artery disease, hyperlipidemia, chronic renal failure, vaccination rates were lower in patients with these comorbidities and additionally diabetes mellitus. The majority of individuals with awareness were informed by healthcare workers. The rate of vaccination among the individuals participating in the study was 18.4%. Vaccination was higher in individuals with awareness. While 5.3% of those who were not vaccinated were hospitalized for pneumonia, those who were vaccinated did not have pneumonia severe enough to require hospitalization. Conclusion: In order to fight with the increasing vaccine hesitancy in our society, healthcare workers should be educated, the media should be supported, and vaccination should be encouraged in every clinic application.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: The study aimed to investigate the effect of thirdhand smoke perception (THS) on the intention to quit smoking. Methods: We measured the perceptions of 285 smokers who admitted and did not admit to the smoking cessation outpatient clinic by the Third Hand Smoke Scale (THS) and their addiction by the Fagerström Nicotine Addiction Scale (FNAS). The factors affecting the intention to quit smoking were examined by logistic regression analysis. Results: While 88.8% of the participants heard about passive smoking, only 14.4% stated that they had heard of thirdhand smoke. Those admitted to the smoking cessation outpatient clinic, those who had at least one smoking quitting attempt, those who wanted to quit smoking, those with high addictions, and those who were banned on smoking at home had a high THS perception, but no difference was observed in the parents. Conclusion: Although SHS is high in smokers, we believe there is a need for the perception of THS to be supported to want and try to quit smoking. Even though the perception of THS, which has been studied for more than 10 years, is not at the desired level, it will be a strong psycho-technique with the concrete data it reveals in quitting smoking with the social training and orientations to be given.
{"title":"The effect of thirdhand smoke belief on intention to quit smoking","authors":"Süleyman Özsari, Derya Kocadağ","doi":"10.38053/acmj.1320463","DOIUrl":"https://doi.org/10.38053/acmj.1320463","url":null,"abstract":"Aims: The study aimed to investigate the effect of thirdhand smoke perception (THS) on the intention to quit smoking. Methods: We measured the perceptions of 285 smokers who admitted and did not admit to the smoking cessation outpatient clinic by the Third Hand Smoke Scale (THS) and their addiction by the Fagerström Nicotine Addiction Scale (FNAS). The factors affecting the intention to quit smoking were examined by logistic regression analysis. Results: While 88.8% of the participants heard about passive smoking, only 14.4% stated that they had heard of thirdhand smoke. Those admitted to the smoking cessation outpatient clinic, those who had at least one smoking quitting attempt, those who wanted to quit smoking, those with high addictions, and those who were banned on smoking at home had a high THS perception, but no difference was observed in the parents. Conclusion: Although SHS is high in smokers, we believe there is a need for the perception of THS to be supported to want and try to quit smoking. Even though the perception of THS, which has been studied for more than 10 years, is not at the desired level, it will be a strong psycho-technique with the concrete data it reveals in quitting smoking with the social training and orientations to be given.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sevim Baltalı, Veysel Erden, Seda Seven, Mehmet Baltali, Sibel Bülgen, B. Gürbulak
Aims: Psychological factors play a significant role in predicting postoperative pain. However, the impact of insomnia on acute postoperative pain is little known. The aim of this study was to investigate the relationship between insomnia and acute postoperative pain. Methods: We performed a case-control study in patients undergoing elective laparoscopic cholecystectomy. Patients with an Insomnia Severity Index (ISI) score >14 were allocated to an insomnia group (n=35) and those with an ISI score
{"title":"The relationship between insomnia and acute postoperative pain: a case-control study on laparoscopic cholecystectomy patients","authors":"Sevim Baltalı, Veysel Erden, Seda Seven, Mehmet Baltali, Sibel Bülgen, B. Gürbulak","doi":"10.38053/acmj.1295914","DOIUrl":"https://doi.org/10.38053/acmj.1295914","url":null,"abstract":"Aims: Psychological factors play a significant role in predicting postoperative pain. However, the impact of insomnia on acute postoperative pain is little known. The aim of this study was to investigate the relationship between insomnia and acute postoperative pain. Methods: We performed a case-control study in patients undergoing elective laparoscopic cholecystectomy. Patients with an Insomnia Severity Index (ISI) score >14 were allocated to an insomnia group (n=35) and those with an ISI score","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：