Fatih Gölgelioğlu, Aydoğan Aşkin, Mehmet Cihat Gündoğdu, Mehmet Fatih Uzun, Bige Kağan Dedetürk, Mustafa Yalın
Aims: This study aimed to investigate the use of a convolutional neural network (CNN) deep learning approach to accurately identify total knee arthroplasty (TKA) implants from X-ray radiographs. Methods: This retrospective study employed a deep learning CNN system to analyze pre-revision and post-operative knee X-rays from TKA patients. We excluded cases involving unicondylar and revision knee replacements, as well as low-quality or unavailable X-ray images and those with other implants. Ten cruciate-retaining TKA replacement models were assessed from various manufacturers. The training set comprised 69% of the data, with the remaining 31% in the test set, augmented due to limited images. Evaluation metrics included accuracy and F1 score, and we developed the software in Python using the TensorFlow library for the CNN method. A computer scientist with AI expertise managed data processing and testing, calculating specificity, sensitivity, and accuracy to assess CNN performance. Results: In this study, a total of 282 AP and lateral X-rays from 141 patients were examined, encompassing 10 distinct knee prosthesis models from various manufacturers, each with varying X-ray counts. The CNN technique exhibited flawless accuracy, achieving a 100% identification rate for both the manufacturer and model of TKA across all 10 different models. Furthermore, the CNN method demonstrated exceptional specificity and sensitivity, consistently reaching 100% for each individual implant model. Conclusion: This study underscores the impressive capacity of deep learning AI algorithms to precisely identify knee arthroplasty implants from X-ray radiographs. It highlights AI’s ability to detect subtle changes imperceptible to humans, execute precise computations, and handle extensive data. The accurate recognition of knee replacement implants using AI algorithms prior to revision surgeries promises to enhance procedure efficiency and outcomes.
目的：本研究旨在调查卷积神经网络 (CNN) 深度学习方法的使用情况，以便从 X 光片中准确识别全膝关节置换术 (TKA) 植入物。 方法：这项回顾性研究采用深度学习 CNN 系统分析了 TKA 患者术前和术后的膝关节 X 光片。我们排除了涉及单髁膝关节置换术和翻修膝关节置换术的病例、低质量或无法获得的 X 光图像以及使用其他植入物的病例。我们评估了来自不同制造商的十种十字韧带固定 TKA 置换模型。训练集包括 69% 的数据，其余 31% 的数据为测试集，由于图像有限，测试集的数据有所增加。评估指标包括准确率和 F1 分数，我们使用 TensorFlow 库在 Python 中开发了用于 CNN 方法的软件。一位具有人工智能专业知识的计算机科学家负责管理数据处理和测试，计算特异性、灵敏度和准确性，以评估 CNN 的性能。 结果本研究共检查了 141 名患者的 282 张 AP 和侧位 X 光片，包括来自不同制造商的 10 种不同膝关节假体型号，每种型号的 X 光片数量各不相同。CNN 技术表现出完美无瑕的准确性，对所有 10 种不同型号的 TKA 制造商和型号的识别率均达到 100%。此外，CNN 方法还表现出卓越的特异性和灵敏度，对每种假体型号的识别率始终保持在 100%。 结论本研究强调了深度学习人工智能算法从 X 光片中精确识别膝关节置换植入物的惊人能力。它凸显了人工智能检测人类难以察觉的细微变化、执行精确计算和处理大量数据的能力。在翻修手术前使用人工智能算法准确识别膝关节置换植入物有望提高手术效率和效果。
{"title":"Can artificial intelligence algorithms recognize knee arthroplasty implants from X-ray radiographs?","authors":"Fatih Gölgelioğlu, Aydoğan Aşkin, Mehmet Cihat Gündoğdu, Mehmet Fatih Uzun, Bige Kağan Dedetürk, Mustafa Yalın","doi":"10.38053/acmj.1356979","DOIUrl":"https://doi.org/10.38053/acmj.1356979","url":null,"abstract":"Aims: This study aimed to investigate the use of a convolutional neural network (CNN) deep learning approach to accurately identify total knee arthroplasty (TKA) implants from X-ray radiographs. Methods: This retrospective study employed a deep learning CNN system to analyze pre-revision and post-operative knee X-rays from TKA patients. We excluded cases involving unicondylar and revision knee replacements, as well as low-quality or unavailable X-ray images and those with other implants. Ten cruciate-retaining TKA replacement models were assessed from various manufacturers. The training set comprised 69% of the data, with the remaining 31% in the test set, augmented due to limited images. Evaluation metrics included accuracy and F1 score, and we developed the software in Python using the TensorFlow library for the CNN method. A computer scientist with AI expertise managed data processing and testing, calculating specificity, sensitivity, and accuracy to assess CNN performance. Results: In this study, a total of 282 AP and lateral X-rays from 141 patients were examined, encompassing 10 distinct knee prosthesis models from various manufacturers, each with varying X-ray counts. The CNN technique exhibited flawless accuracy, achieving a 100% identification rate for both the manufacturer and model of TKA across all 10 different models. Furthermore, the CNN method demonstrated exceptional specificity and sensitivity, consistently reaching 100% for each individual implant model. Conclusion: This study underscores the impressive capacity of deep learning AI algorithms to precisely identify knee arthroplasty implants from X-ray radiographs. It highlights AI’s ability to detect subtle changes imperceptible to humans, execute precise computations, and handle extensive data. The accurate recognition of knee replacement implants using AI algorithms prior to revision surgeries promises to enhance procedure efficiency and outcomes.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: To share the 7-year experience of a single center in the application of regional intravenous anesthesia (RIVA) for surgical treatment of cubital tunnel syndrome (CTS) caused by compression of the ulnar nerve in the elbow region. Methods: A total of 100 patients with CTS who were operated with the RIVA technique at a single center between 2012 and 2019 were retrospectively analyzed. In the RIVA technique, after providing venous drainage in the operated side arm, the double cuff tourniquet was inflated in the upper arm, and anesthesia was provided by administering a 30-40 mL solution of 2% lidocaine (3 mg/kg) diluted in 1% saline through the intravenous catheter. The surgical methods applied (transposition or internal neurolysis with external decompression), demographic data, preoperative and postoperative visual analog scale (VAS) scores for pain were compared. Results: Out of 100 patients, 30 patients underwent surgical transposition (group 1) while internal neurolysis with external decompression was performed in 70 patients (group 2). The mean age of patients in groups 1 and 2 was 66.3±12.1 and 60.6±11.7 years, respectively. Women accounted for 73.3% of patients in group 1 and 87.1% of patients in group 2. The left side was affected in 18 (60%) patients in group 1 and 42 (60%) patients in group 2. In group 1, the mean postoperative 3rd-week VAS score (1.96±0.76) was significantly lower than the mean preoperative VAS score (7.46±0.93; p
{"title":"Single-center experience of cubital tunnel syndrome surgery performing transposition or internal neurolysis with external decompression under regional intravenous anesthesia technique","authors":"Ali Güler","doi":"10.38053/acmj.1344313","DOIUrl":"https://doi.org/10.38053/acmj.1344313","url":null,"abstract":"Aims: To share the 7-year experience of a single center in the application of regional intravenous anesthesia (RIVA) for surgical treatment of cubital tunnel syndrome (CTS) caused by compression of the ulnar nerve in the elbow region. Methods: A total of 100 patients with CTS who were operated with the RIVA technique at a single center between 2012 and 2019 were retrospectively analyzed. In the RIVA technique, after providing venous drainage in the operated side arm, the double cuff tourniquet was inflated in the upper arm, and anesthesia was provided by administering a 30-40 mL solution of 2% lidocaine (3 mg/kg) diluted in 1% saline through the intravenous catheter. The surgical methods applied (transposition or internal neurolysis with external decompression), demographic data, preoperative and postoperative visual analog scale (VAS) scores for pain were compared. Results: Out of 100 patients, 30 patients underwent surgical transposition (group 1) while internal neurolysis with external decompression was performed in 70 patients (group 2). The mean age of patients in groups 1 and 2 was 66.3±12.1 and 60.6±11.7 years, respectively. Women accounted for 73.3% of patients in group 1 and 87.1% of patients in group 2. The left side was affected in 18 (60%) patients in group 1 and 42 (60%) patients in group 2. In group 1, the mean postoperative 3rd-week VAS score (1.96±0.76) was significantly lower than the mean preoperative VAS score (7.46±0.93; p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: The main objective of this study is to investigate the impact of a pre-dialysis education program on the selection of vascular access during the initiation of maintenance hemodialysis therapy and the short-term impact of this education on patient outcomes. Methods: The data were collected from two different times in the past from patients under maintenance hemodialysis: the first group consisted of a group of patients who received a predialysis education program (intervention group) from a dedicated nephrologist, and the second group included those who did not undergo a control program (control group). Predialysis education program involved six modules addressing understanding kidney disease, diet, and nutrition, treatment options for end-stage kidney disease, dialysis procedures, medication management, and self-care/independence. Patients aged ≥18 years were enrolled in the study. The patients were compared according to their clinical status during the onset of maintenance hemodialysis, including vascular access type, serum potassium level, previous hospitalization, and urgent hemodialysis need. Additionally, the hospitalization and infection rates within 6 months following the onset of maintenance hemodialysis were compared. P
{"title":"Predialysis education program and early vascular access: a single center experience","authors":"Mahmud Islam, Kenan Evren Öztop","doi":"10.38053/acmj.1331260","DOIUrl":"https://doi.org/10.38053/acmj.1331260","url":null,"abstract":"Aims: The main objective of this study is to investigate the impact of a pre-dialysis education program on the selection of vascular access during the initiation of maintenance hemodialysis therapy and the short-term impact of this education on patient outcomes. Methods: The data were collected from two different times in the past from patients under maintenance hemodialysis: the first group consisted of a group of patients who received a predialysis education program (intervention group) from a dedicated nephrologist, and the second group included those who did not undergo a control program (control group). Predialysis education program involved six modules addressing understanding kidney disease, diet, and nutrition, treatment options for end-stage kidney disease, dialysis procedures, medication management, and self-care/independence. Patients aged ≥18 years were enrolled in the study. The patients were compared according to their clinical status during the onset of maintenance hemodialysis, including vascular access type, serum potassium level, previous hospitalization, and urgent hemodialysis need. Additionally, the hospitalization and infection rates within 6 months following the onset of maintenance hemodialysis were compared. P","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Hemoglobin/red cell distribution width ratio (HRR) has been defined as an effective prognostic factor in various malignancies. The aim of this study is to investigate the prognostic role of HRR in locally advanced lung adenocarcinoma. Methods: 626 patients diagnosed with locally advanced lung adenocarcinoma were screened. The best cut-off point of HRR for overall survival (OS) and progression free survival (PFS) was determined by ROC analysis. A HRR cut-off value was determined, patients were classified as having lower or higher HRR. Both groups’ clinical, demographic, laboratory values were compared. To identify independent predictors of prognosis, multivariate cox regression analysis was used. Results: A total of119 patients were included. The best cut-off point of HRR in determining OS was 0.963%.HRR below the cut-off value increased mortality by 2.2fold.The group with HRR
{"title":"Hemoglobin red cell distribution width ratio as a prognostic marker in patients with locally advanced lung adenocarcinoma","authors":"Hasret Gizem Kurt, Ayperi Öztürk, Figen ÖZTÜRK ERGÜR","doi":"10.38053/acmj.1322201","DOIUrl":"https://doi.org/10.38053/acmj.1322201","url":null,"abstract":"Aims: Hemoglobin/red cell distribution width ratio (HRR) has been defined as an effective prognostic factor in various malignancies. The aim of this study is to investigate the prognostic role of HRR in locally advanced lung adenocarcinoma. Methods: 626 patients diagnosed with locally advanced lung adenocarcinoma were screened. The best cut-off point of HRR for overall survival (OS) and progression free survival (PFS) was determined by ROC analysis. A HRR cut-off value was determined, patients were classified as having lower or higher HRR. Both groups’ clinical, demographic, laboratory values were compared. To identify independent predictors of prognosis, multivariate cox regression analysis was used. Results: A total of119 patients were included. The best cut-off point of HRR in determining OS was 0.963%.HRR below the cut-off value increased mortality by 2.2fold.The group with HRR","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Betul Cengiz ElçioĞlu, Yasemin Demi̇rci̇, Mert Pehlivan Altin, Erol Gürsoy, V. Aytekin, S. Aytekin
Aims: Cardiovascular disease is the leading cause of morbidity and mortality in renal transplant patients. In our study, we aimed to determine the cardiovascular (CV) risk factors, the prevalence and determinants of coronary artery disease (CAD) in patients who underwent kidney transplantation in our center. Methods: One hundred sixty nine patients who underwent kidney transplantation in our center were included in the study retrospectively. Demographic and clinical characteristics of the patients, cardiac evaluation findings and further examination results were scanned from the database of our center. Results: The mean age of the patients was 42.86±12.97 years and 43.19% were female. The most common etiological factors for the development of end-stage renal disease were hypertension (HT) and diabetes mellitus (DM). Ninety seven patients (57.4%) were undergoing dialysis, 4 of whom were on peritoneal dialysis. Renal transplant was performed from a cadaver in two patients and from a living donor in the other patients. CAD was detected in 29 patients (17.15%). The most prevalent CV risk factors were HT and hyperlipidemia (HL). Multivariate logistic regression analysis revealed that age, DM, HL and dialysis history were independent risk factors for the development of CAD. In the postoperative follow-ups, no death or acute coronary syndrome was observed during the hospitalization period. Conclusion: Prevalence of CV risk factors is high in renal transplant candidates. Our findings support the need for a detailed cardiac evaluation and effective management of CV risk factors in patients preparing for kidney transplantation.
{"title":"Evaluation of cardiovascular risk factors, prevalence and determinants of coronary artery disease in renal transplant patients: a single center experience","authors":"Betul Cengiz ElçioĞlu, Yasemin Demi̇rci̇, Mert Pehlivan Altin, Erol Gürsoy, V. Aytekin, S. Aytekin","doi":"10.38053/acmj.1350404","DOIUrl":"https://doi.org/10.38053/acmj.1350404","url":null,"abstract":"Aims: Cardiovascular disease is the leading cause of morbidity and mortality in renal transplant patients. In our study, we aimed to determine the cardiovascular (CV) risk factors, the prevalence and determinants of coronary artery disease (CAD) in patients who underwent kidney transplantation in our center. Methods: One hundred sixty nine patients who underwent kidney transplantation in our center were included in the study retrospectively. Demographic and clinical characteristics of the patients, cardiac evaluation findings and further examination results were scanned from the database of our center. Results: The mean age of the patients was 42.86±12.97 years and 43.19% were female. The most common etiological factors for the development of end-stage renal disease were hypertension (HT) and diabetes mellitus (DM). Ninety seven patients (57.4%) were undergoing dialysis, 4 of whom were on peritoneal dialysis. Renal transplant was performed from a cadaver in two patients and from a living donor in the other patients. CAD was detected in 29 patients (17.15%). The most prevalent CV risk factors were HT and hyperlipidemia (HL). Multivariate logistic regression analysis revealed that age, DM, HL and dialysis history were independent risk factors for the development of CAD. In the postoperative follow-ups, no death or acute coronary syndrome was observed during the hospitalization period. Conclusion: Prevalence of CV risk factors is high in renal transplant candidates. Our findings support the need for a detailed cardiac evaluation and effective management of CV risk factors in patients preparing for kidney transplantation.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Septic arthritis is joint inflammation. It is an orthopedic emergency that requires prompt diagnosis and treatment. In this study, it was aimed to examine the distribution and antibiotic resistance profiles of microorganisms isolated from joint fluid samples taken from patients who applied to the orthopedic clinic of our hospital in the last five years. Methods: In our study, 1162 joint fluid samples were sent to the medical microbiology laboratory of our hospital from the orthopedics and traumatology clinic between January 01, 2018 and December 31, 2022. Joint fluid samples taken from clinically appropriate patients under sterile conditions were incubated in a BacT/Alert 3D (Biomerieux, France) culture device. Bacteria isolated from 164 specimens with growth detected, were identified by matrix-mediated laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) based VITEK MS (Biomerieux, France). Antibiotic susceptibility tests were performed on the VITEK 2 Compact (Biomerieux, France) device. Results: Staphylococcus aureus (S. aureus) (29.3%) and coagulase negative Staphylococci (CNS) (29.3%) were the most commonly grown microorganisms. Other microorganisms grown were Streptococcus spp. (9.1%), Enterococcus spp. (6.1%), Pseudomonas aeruginosa (P. aeuruginosa) (7.3%), Escherichiae coli (E. coli) (4.3%) and Klebsiella pneumoniae (K. pneumoniae) (4.3%). When antibiotic susceptibility results were evaluated according to EUCAST restricted reporting criteria, linezolid in Gram-positive strains, amikacin in Enterobacterales, colistin and tigecycline in nonfermentative Gram-negative bacteria were found to be the most susceptible antibiotics. Conclusion: The continuous change in antibiotic susceptibility profiles in joint infections, the long duration of treatment and follow-up, and the increase in polymicrobial infections require regular monitoring of culture and antibiotic susceptibility tests. In our study, the distribution of microorganisms isolated from joint fluid samples of our hospital and the determination of antibiotic resistance profiles will contribute to the clinician in terms of guiding empirical treatment.
{"title":"Evaluation of distribution and susceptibility of microorganisms isolated from joint fluid cultures: five-year data","authors":"Halil Er, Özlem Koca, Nevgün Sepin Özen","doi":"10.38053/acmj.1342396","DOIUrl":"https://doi.org/10.38053/acmj.1342396","url":null,"abstract":"Aims: Septic arthritis is joint inflammation. It is an orthopedic emergency that requires prompt diagnosis and treatment. In this study, it was aimed to examine the distribution and antibiotic resistance profiles of microorganisms isolated from joint fluid samples taken from patients who applied to the orthopedic clinic of our hospital in the last five years. Methods: In our study, 1162 joint fluid samples were sent to the medical microbiology laboratory of our hospital from the orthopedics and traumatology clinic between January 01, 2018 and December 31, 2022. Joint fluid samples taken from clinically appropriate patients under sterile conditions were incubated in a BacT/Alert 3D (Biomerieux, France) culture device. Bacteria isolated from 164 specimens with growth detected, were identified by matrix-mediated laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) based VITEK MS (Biomerieux, France). Antibiotic susceptibility tests were performed on the VITEK 2 Compact (Biomerieux, France) device. Results: Staphylococcus aureus (S. aureus) (29.3%) and coagulase negative Staphylococci (CNS) (29.3%) were the most commonly grown microorganisms. Other microorganisms grown were Streptococcus spp. (9.1%), Enterococcus spp. (6.1%), Pseudomonas aeruginosa (P. aeuruginosa) (7.3%), Escherichiae coli (E. coli) (4.3%) and Klebsiella pneumoniae (K. pneumoniae) (4.3%). When antibiotic susceptibility results were evaluated according to EUCAST restricted reporting criteria, linezolid in Gram-positive strains, amikacin in Enterobacterales, colistin and tigecycline in nonfermentative Gram-negative bacteria were found to be the most susceptible antibiotics. Conclusion: The continuous change in antibiotic susceptibility profiles in joint infections, the long duration of treatment and follow-up, and the increase in polymicrobial infections require regular monitoring of culture and antibiotic susceptibility tests. In our study, the distribution of microorganisms isolated from joint fluid samples of our hospital and the determination of antibiotic resistance profiles will contribute to the clinician in terms of guiding empirical treatment.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: The present study explored if pentraxin-3 (PTX-3) levels, which would be boosted due to cardiac damage by gentamicin, can be regressed thanks to Pycnogenol, which was also previously shown to have desirable impacts on cardiovascular diseases. Methods: In the study, we recruited 28 8-10-week-old male Sprague-Dawley rats into four groups: control, gentamicin, gentamycin+Pycnogenol, and Pycnogenol. We stained the tissue samples with hematoxylin-eosin and Masson’s trichome dye for histopathological analysis. Then, malondialdehyde (MDA) levels were measured using the spectrophotometric technique. In addition, we measured PTX-3 levels in the heart tissues by an immunohistochemical method. Results: We discovered the heart tissue samples of the rats in the control and Pycnogenol groups were histologically normal. As well as mononuclear cell increase and degeneration of cardiac muscle cells, we observed mild congestion in the gentamicin group compared to the control group. Despite more significant damage to the heart tissue in the gentamicin+Pycnogenol group compared to the control group, we found that the histopathological damage regressed in this group compared to the gentamicin group. While PTX-3 immunoreactivity was similar between the control and Pycnogenol groups, it was significantly elevated in the gentamicin group compared to the control group (p < 0.001). Moreover, the gentamicin+Pycnogenol group had decreased PTX-3 immunoreactivity than the gentamicin group. While MDA values followed a similar pattern between the control and Pycnogenol groups, these values were found to be significantly increased in the gentamicin group compared to the control group (p < 0.001). These values, however, were decreased in the gentamicin+Pycnogenol group compared to the gentamicin group. Conclusion: In a nutshell, the present study was able to demonstrate that gentamicin may lead to cardiac damage by boosting PTX-3 levels and that the damage can be regressed thanks to the Pycnogenol treatment.
{"title":"Exploring the impacts of Pycnogenol on pentraxin-3 levels in the heart tissue of rats administered with gentamicin","authors":"Tolga Çakmak","doi":"10.38053/acmj.1328767","DOIUrl":"https://doi.org/10.38053/acmj.1328767","url":null,"abstract":"Aims: The present study explored if pentraxin-3 (PTX-3) levels, which would be boosted due to cardiac damage by gentamicin, can be regressed thanks to Pycnogenol, which was also previously shown to have desirable impacts on cardiovascular diseases. Methods: In the study, we recruited 28 8-10-week-old male Sprague-Dawley rats into four groups: control, gentamicin, gentamycin+Pycnogenol, and Pycnogenol. We stained the tissue samples with hematoxylin-eosin and Masson’s trichome dye for histopathological analysis. Then, malondialdehyde (MDA) levels were measured using the spectrophotometric technique. In addition, we measured PTX-3 levels in the heart tissues by an immunohistochemical method. Results: We discovered the heart tissue samples of the rats in the control and Pycnogenol groups were histologically normal. As well as mononuclear cell increase and degeneration of cardiac muscle cells, we observed mild congestion in the gentamicin group compared to the control group. Despite more significant damage to the heart tissue in the gentamicin+Pycnogenol group compared to the control group, we found that the histopathological damage regressed in this group compared to the gentamicin group. While PTX-3 immunoreactivity was similar between the control and Pycnogenol groups, it was significantly elevated in the gentamicin group compared to the control group (p < 0.001). Moreover, the gentamicin+Pycnogenol group had decreased PTX-3 immunoreactivity than the gentamicin group. While MDA values followed a similar pattern between the control and Pycnogenol groups, these values were found to be significantly increased in the gentamicin group compared to the control group (p < 0.001). These values, however, were decreased in the gentamicin+Pycnogenol group compared to the gentamicin group. Conclusion: In a nutshell, the present study was able to demonstrate that gentamicin may lead to cardiac damage by boosting PTX-3 levels and that the damage can be regressed thanks to the Pycnogenol treatment.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Coronary collateral circulation consists of vascular channels activated to maintain perfusion in major epicardial coronary arteries in severe stenosis or occlusion. Yet, coronary collateral development (CCD) in diabetic patients was previously proven to be poor. Urotesin-II (U-II) is famous for being the most potent vasoconstrictor agent, and plasma levels are known to elevate in diabetic patients and play an important role in diabetic complications. In this study, we inquired about the link between U-II levels and the development of coronary collaterals between diabetic and non-diabetic patients with coronary artery disease (CAD). Methods: We recruited 31 diabetic and 30 non-diabetic patients with 95% or more coronary artery stenosis or occlusion and considered Rentrop’s classification for grading collaterals. In this sense, while Rentrop grades 0-1 are regarded as poor CCD, Rentrop grades 2-3 correspond to well-developed collaterals. Moreover, we compared the patients’ serum levels of U-II by the degree of CCD. Results: The findings revealed that demographic characteristics did not significantly differ between the groups (p >0.05). Although CCD seemed worse in diabetic patients than those without diabetes (DM), the finding was not statistically significant. However, the diabetic patients had significantly higher U-II levels than non-diabetic patients (388.1±314.2 vs. 229.8±216.9, p=0.026). Despite not being significant, U-II levels were higher in patients with poor CCD than those with well-developed collaterals in the non-diabetic group (370.6±298; 178.6±158.3, p=0.2). In the diabetic group, on the other hand, U-II levels were significantly higher in patients with poor CCD and significantly lower in patients with good CCD (582.7±316.4 and 180.4±121.6, respectively; p
{"title":"Inquiring about the link between urotensin-II and coronary collateral development in coronary artery patients with and without diabetes","authors":"Yasin Karakuş, Nusret Açikgöz","doi":"10.38053/acmj.1330608","DOIUrl":"https://doi.org/10.38053/acmj.1330608","url":null,"abstract":"Aims: Coronary collateral circulation consists of vascular channels activated to maintain perfusion in major epicardial coronary arteries in severe stenosis or occlusion. Yet, coronary collateral development (CCD) in diabetic patients was previously proven to be poor. Urotesin-II (U-II) is famous for being the most potent vasoconstrictor agent, and plasma levels are known to elevate in diabetic patients and play an important role in diabetic complications. In this study, we inquired about the link between U-II levels and the development of coronary collaterals between diabetic and non-diabetic patients with coronary artery disease (CAD). Methods: We recruited 31 diabetic and 30 non-diabetic patients with 95% or more coronary artery stenosis or occlusion and considered Rentrop’s classification for grading collaterals. In this sense, while Rentrop grades 0-1 are regarded as poor CCD, Rentrop grades 2-3 correspond to well-developed collaterals. Moreover, we compared the patients’ serum levels of U-II by the degree of CCD. Results: The findings revealed that demographic characteristics did not significantly differ between the groups (p >0.05). Although CCD seemed worse in diabetic patients than those without diabetes (DM), the finding was not statistically significant. However, the diabetic patients had significantly higher U-II levels than non-diabetic patients (388.1±314.2 vs. 229.8±216.9, p=0.026). Despite not being significant, U-II levels were higher in patients with poor CCD than those with well-developed collaterals in the non-diabetic group (370.6±298; 178.6±158.3, p=0.2). In the diabetic group, on the other hand, U-II levels were significantly higher in patients with poor CCD and significantly lower in patients with good CCD (582.7±316.4 and 180.4±121.6, respectively; p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Echinococcus granulosus is the causative agent of hydatid cyst, or cystic echinococcosis (CE), with its current name. Echinococcus granulosus is a zoonotic cestode; commonly found in humans and farm animals. In cystic echinococcosis infection, transmission occurs by oral ingestion of parasite eggs excreted in infected dog feces. The larval form is responsible for the formation of slowly growing cysts in the organs and tissues of mammals such as humans, sheep, goats and cattle. In this study, it was aimed to compare indirect hemagglutination (IHA) and immunochromatographic (ICT) methods from the sera of patients with suspected CE and to evaluate serological tests based on imaging and clinical diagnosis. Methods: Between 31 October 2022 and 31 January 2023, blood samples of 95 patients with suspected CE from different units of our hospital and for whom IHA was routinely requested were included in the study prospectively. VIRAPID® Hydatidosis (Vircell, Granada, Spain) test using the immunochromatographic method and ELI.H.A. Echinococcus (ELITech Microbio, France) test was studied in accordance with the manufacturer’s instructions. Results: Based on clinical and imaging methods of 95 patients included in our study, 64 (63.1%) were diagnosed with hydatid cyst. Based on imaging and clinical diagnosis; sensitivity, specificity, positive predictive value and negative predictive values were calculated as 81.3%, 96.8%, 98.1%, 71.4% for the IHA test, and were calculated as 75.0%, 93.5%, 96.6%, 64.4% for the ICT test, respectively. Good agreement was found between the two tests (percent agreement=68.0%; kappa value=0.682; p
{"title":"Evaluation of immunochromatography method in the diagnosis of cystic echinococcosis","authors":"Özlem Koca, Özgül Çetinkaya, Aylin Erman Daloğlu, Y. Çekin, Hatice Özen","doi":"10.38053/acmj.1345403","DOIUrl":"https://doi.org/10.38053/acmj.1345403","url":null,"abstract":"Aims: Echinococcus granulosus is the causative agent of hydatid cyst, or cystic echinococcosis (CE), with its current name. Echinococcus granulosus is a zoonotic cestode; commonly found in humans and farm animals. In cystic echinococcosis infection, transmission occurs by oral ingestion of parasite eggs excreted in infected dog feces. The larval form is responsible for the formation of slowly growing cysts in the organs and tissues of mammals such as humans, sheep, goats and cattle. In this study, it was aimed to compare indirect hemagglutination (IHA) and immunochromatographic (ICT) methods from the sera of patients with suspected CE and to evaluate serological tests based on imaging and clinical diagnosis. Methods: Between 31 October 2022 and 31 January 2023, blood samples of 95 patients with suspected CE from different units of our hospital and for whom IHA was routinely requested were included in the study prospectively. VIRAPID® Hydatidosis (Vircell, Granada, Spain) test using the immunochromatographic method and ELI.H.A. Echinococcus (ELITech Microbio, France) test was studied in accordance with the manufacturer’s instructions. Results: Based on clinical and imaging methods of 95 patients included in our study, 64 (63.1%) were diagnosed with hydatid cyst. Based on imaging and clinical diagnosis; sensitivity, specificity, positive predictive value and negative predictive values were calculated as 81.3%, 96.8%, 98.1%, 71.4% for the IHA test, and were calculated as 75.0%, 93.5%, 96.6%, 64.4% for the ICT test, respectively. Good agreement was found between the two tests (percent agreement=68.0%; kappa value=0.682; p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: The left anterior descending artery is the most involved vessel in the myocardial bridging of the coronary arteries. Revascularization of the left anterior descending artery (LAD) is considered an essential component of coronary artery bypass grafting (CABG) procedures. This study aims to evaluate the correlation between angiographic views of the coronary artery and intraoperative findings of the left anterior descending artery myocardial bridge (LADMB). Methods: The records of patients who underwent the CABG procedure between January 2015 and October 2022 were reviewed retrospectively. A total of 349 patients who had LADMB on coronary angiography (CAG) images and/or intraoperatively were evaluated. Patients were divided into two groups. The CAG group (n=50) consisted of patients with angiographic LADMB, and the CABG group (n=40) consisted of patients with LADMB that was detected intraoperatively. The correlation between myocardial bridge signs of the LAD in CAG and intraoperative observations was investigated. Results: In the coronary angiography group, 50 patients had signs of depression on coronary angiography, of whom 35 had LADMB intraoperatively. In the CABG group, 40 patients were found to have a myocardial bridge intraoperatively, and 5 had normal CAG images. The prevalence of LADMB was 11.5%. The sensitivity of CAG was 87.5%, the specificity was 95.15%, the positive predictive value was 70%, and the negative predictive value was 98.32%. Conclusion: The myocardial bridge signs of the LAD on CAG correlate with intraoperative observations with high sensitivity and specificity.
{"title":"The diagnostic accuracy of coronary angiography to detect left anterior descending artery myocardial bridging in coronary artery bypass grafting: a retrospective single-center study","authors":"Sameh Alagha","doi":"10.38053/acmj.1309538","DOIUrl":"https://doi.org/10.38053/acmj.1309538","url":null,"abstract":"Aims: The left anterior descending artery is the most involved vessel in the myocardial bridging of the coronary arteries. Revascularization of the left anterior descending artery (LAD) is considered an essential component of coronary artery bypass grafting (CABG) procedures. This study aims to evaluate the correlation between angiographic views of the coronary artery and intraoperative findings of the left anterior descending artery myocardial bridge (LADMB). Methods: The records of patients who underwent the CABG procedure between January 2015 and October 2022 were reviewed retrospectively. A total of 349 patients who had LADMB on coronary angiography (CAG) images and/or intraoperatively were evaluated. Patients were divided into two groups. The CAG group (n=50) consisted of patients with angiographic LADMB, and the CABG group (n=40) consisted of patients with LADMB that was detected intraoperatively. The correlation between myocardial bridge signs of the LAD in CAG and intraoperative observations was investigated. Results: In the coronary angiography group, 50 patients had signs of depression on coronary angiography, of whom 35 had LADMB intraoperatively. In the CABG group, 40 patients were found to have a myocardial bridge intraoperatively, and 5 had normal CAG images. The prevalence of LADMB was 11.5%. The sensitivity of CAG was 87.5%, the specificity was 95.15%, the positive predictive value was 70%, and the negative predictive value was 98.32%. Conclusion: The myocardial bridge signs of the LAD on CAG correlate with intraoperative observations with high sensitivity and specificity.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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