Şeyma Osmanlıoğlu, K. G. Saçıntı, Merve Aydin, Y. E. Şükür
Aims: This study was conducted to review the clinical, laboratory, and ultrasound findings of patients with a confirmed post-operative adnexal torsion diagnosis in a tertiary university hospital and to reflect the management of adnexal torsion. Methods: 44 patients (ages [15,44] with a median of 30 yr) who had an operation at Ankara University Hospital Gynecology and Obstetrics Clinics between October 2013 and February 2021 and in whom the preoperative diagnosis of adnexal torsion was confirmed intraoperatively were included in this retrospective study. Patients’ complaints, existing risk factors, physical examination, laboratory, and radiological findings were evaluated. Results: 26 (65%) of the patients complained about acute abdominal pain isolated on one side. Torsion was observed on the right side in 29 (66%) patients. Risk factors: History of ovarian torsion in 1 patient (2%), in vitro fertilization treatment in 5 (11%) patients, 4 (9%) of which also had ovarian hyperstimulation syndrome and 2 (5%) of them had polycystic ovary syndrome, and finally, 28 (65%) patients had increased ovarian size on ultrasound. Ovarian blood flow was not observed in 25 (81%) of 31 patients who underwent transvaginal Doppler ultrasound. Preoperative blood examination showed anemia (Hb10000/mm³) in 26 (59%), and an increase of neutrophil-lymphocyte ratio (NLR) (>3) in 36 (82%). Laparoscopy was performed in 37 (84%) patients and laparotomy in 7 (16%). Conclusion: There is no objective diagnostic tool that can definitively lead to the diagnosis of adnexal torsion. It may be recommended to use ultrasound, Doppler, and NLR in addition to clinical findings and anamnesis. Considering the consequences of delay in the treatment, the most appropriate approach would be to perform a laparoscopy if torsion is suspected. Additionally, the patient’s age, menopausal status, ovarian pathology, and desire for fertility are factors that should be considered in the treatment decision, and ovarian protection should be the primary goal.
{"title":"Adnexal torsion: a single-center retrospective study of diagnosis and treatment","authors":"Şeyma Osmanlıoğlu, K. G. Saçıntı, Merve Aydin, Y. E. Şükür","doi":"10.38053/acmj.1298225","DOIUrl":"https://doi.org/10.38053/acmj.1298225","url":null,"abstract":"Aims: This study was conducted to review the clinical, laboratory, and ultrasound findings of patients with a confirmed post-operative adnexal torsion diagnosis in a tertiary university hospital and to reflect the management of adnexal torsion. \u0000Methods: 44 patients (ages [15,44] with a median of 30 yr) who had an operation at Ankara University Hospital Gynecology and Obstetrics Clinics between October 2013 and February 2021 and in whom the preoperative diagnosis of adnexal torsion was confirmed intraoperatively were included in this retrospective study. Patients’ complaints, existing risk factors, physical examination, laboratory, and radiological findings were evaluated. \u0000Results: 26 (65%) of the patients complained about acute abdominal pain isolated on one side. Torsion was observed on the right side in 29 (66%) patients. Risk factors: History of ovarian torsion in 1 patient (2%), in vitro fertilization treatment in 5 (11%) patients, 4 (9%) of which also had ovarian hyperstimulation syndrome and 2 (5%) of them had polycystic ovary syndrome, and finally, 28 (65%) patients had increased ovarian size on ultrasound. Ovarian blood flow was not observed in 25 (81%) of 31 patients who underwent transvaginal Doppler ultrasound. Preoperative blood examination showed anemia (Hb10000/mm³) in 26 (59%), and an increase of neutrophil-lymphocyte ratio (NLR) (>3) in 36 (82%). Laparoscopy was performed in 37 (84%) patients and laparotomy in 7 (16%). \u0000Conclusion: There is no objective diagnostic tool that can definitively lead to the diagnosis of adnexal torsion. It may be recommended to use ultrasound, Doppler, and NLR in addition to clinical findings and anamnesis. Considering the consequences of delay in the treatment, the most appropriate approach would be to perform a laparoscopy if torsion is suspected. Additionally, the patient’s age, menopausal status, ovarian pathology, and desire for fertility are factors that should be considered in the treatment decision, and ovarian protection should be the primary goal.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128288969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Yılmazsoy, A. Özdemir, S. Arslan, Pelin Zeynep Bekin Sarıkaya
Aims: Diagnostic procedures are very important for fetal safety during pregnancy. Magnetic resonance imaging (MRI) is characterized by a higher accuracy rate compared to medical follow-up and post-surgical diagnoses. However, it is very important to use it at the right time in order to maintain cost-effectiveness of the technique. In this study, we aimed to determine the efficacy of MRI in pregnant patients admitted to the emergency department with acute abdominal pain when the etiology has not been defined by other techniques. Methods: The data of pregnant patients who admitted to the emergency department due to acute abdominal pain between January 2013 and February 2018 were retrospectively analyzed. All these patients evaluated with pelvic magnetic resonance screening, as they could not be diagnosed by physical examination findings, laboratory tests, or ultrasonography. Diagnostic performance of MRI, sensitivity, specificity, and negative and positive predictive values were assessed. Results: The etiology of the pain was detected in 29 of 57 patients who applied to the emergency department with acute abdominal pain and evaluated with pelvic MRI. The most common cause of acute abdominal pain was acute appendicitis which all of them histopathologically confirmed (n=14). Pelvic abscess, severe hydronephrosis, giant ovarian cyst, pyelonephritis, ovarian torsion, and uterine fibroid torsion were among other causes. Conclusion: MRI is a highly effective imaging method for diagnosing both acute appendicitis and other pelvic emergencies. Therefore, it would be beneficial for the diagnosis in pregnant patients with acute abdominal pain.
{"title":"Efficacy of magnetic resonance imaging among pregnant patients diagnosed with acute abdomen in the emergency department","authors":"Y. Yılmazsoy, A. Özdemir, S. Arslan, Pelin Zeynep Bekin Sarıkaya","doi":"10.38053/acmj.1254096","DOIUrl":"https://doi.org/10.38053/acmj.1254096","url":null,"abstract":"Aims: Diagnostic procedures are very important for fetal safety during pregnancy. Magnetic resonance imaging (MRI) is characterized by a higher accuracy rate compared to medical follow-up and post-surgical diagnoses. However, it is very important to use it at the right time in order to maintain cost-effectiveness of the technique. In this study, we aimed to determine the efficacy of MRI in pregnant patients admitted to the emergency department with acute abdominal pain when the etiology has not been defined by other techniques. \u0000Methods: The data of pregnant patients who admitted to the emergency department due to acute abdominal pain between January 2013 and February 2018 were retrospectively analyzed. All these patients evaluated with pelvic magnetic resonance screening, as they could not be diagnosed by physical examination findings, laboratory tests, or ultrasonography. Diagnostic performance of MRI, sensitivity, specificity, and negative and positive predictive values were assessed. \u0000Results: The etiology of the pain was detected in 29 of 57 patients who applied to the emergency department with acute abdominal pain and evaluated with pelvic MRI. The most common cause of acute abdominal pain was acute appendicitis which all of them histopathologically confirmed (n=14). Pelvic abscess, severe hydronephrosis, giant ovarian cyst, pyelonephritis, ovarian torsion, and uterine fibroid torsion were among other causes. \u0000Conclusion: MRI is a highly effective imaging method for diagnosing both acute appendicitis and other pelvic emergencies. Therefore, it would be beneficial for the diagnosis in pregnant patients with acute abdominal pain.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121176022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: The study aimed to evaluate possible intrauterine pathologies that may not be visible in basal transvaginal ultrasonography in infertile patients using saline infusion sonohysterography. Methods: Between January 2019 and January 2020, 110 patients who presented to the Ankara University Faculty of Medicine, Obstetrics and Gynecology Infertility Polyclinic were enrolled in the study. Saline infusion sonohysterography was performed on primary and secondary infertile patients who were not diagnosed with endometrial pathology via ultrasonography. Results: Pathological findings were detected in 11 out of 110 patients (10.6%) during saline infusion sonohysterography, including polyps, myomas, and adhesions. These patients were referred to hysteroscopy by their practitioner. After the procedure, pathological findings were detected in 54.5% of cases by hysteroscopy. According to these data, the sensitivity of saline infusion sonohysterography in detecting intracavitary pathologies was 60%, specificity was 80.7%, positive predictive value was 54.5%, negative predictive value was 84%, and reliability was 75%. Conclusion: Saline infusion sonohysterography can detect endometrial pathologies not identified by TV USG, suggesting its cost-effective addition to routine evaluations for infertile patients and potential endometrial pathologies.
{"title":"The role of saline infusion sonohysterography in the evaluation of infertility","authors":"Ekin Özokçu, S. Şahin Aker, Eser Ağar, B. Berker","doi":"10.38053/acmj.1261902","DOIUrl":"https://doi.org/10.38053/acmj.1261902","url":null,"abstract":"Aims: The study aimed to evaluate possible intrauterine pathologies that may not be visible in basal transvaginal ultrasonography in infertile patients using saline infusion sonohysterography. \u0000Methods: Between January 2019 and January 2020, 110 patients who presented to the Ankara University Faculty of Medicine, Obstetrics and Gynecology Infertility Polyclinic were enrolled in the study. Saline infusion sonohysterography was performed on primary and secondary infertile patients who were not diagnosed with endometrial pathology via ultrasonography. \u0000Results: Pathological findings were detected in 11 out of 110 patients (10.6%) during saline infusion sonohysterography, including polyps, myomas, and adhesions. These patients were referred to hysteroscopy by their practitioner. After the procedure, pathological findings were detected in 54.5% of cases by hysteroscopy. According to these data, the sensitivity of saline infusion sonohysterography in detecting intracavitary pathologies was 60%, specificity was 80.7%, positive predictive value was 54.5%, negative predictive value was 84%, and reliability was 75%. \u0000Conclusion: Saline infusion sonohysterography can detect endometrial pathologies not identified by TV USG, suggesting its cost-effective addition to routine evaluations for infertile patients and potential endometrial pathologies.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127300136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Hemorrhoids is a common anorectal disorder and significantly affects quality of life. Although the number of global studies on hemorrhoids has increased in recent years, there is still no bibliometric study in the literature. In this study, it aimed that analyzing the scientific articles published on hemorrhoids holistically. Methods: The articles published between 1980 and 2021 were analyzed using bibliometric and statistical methods on hemorrhoids. Network visualization maps were used to identify trending topics and international collaborations. Spearman’s correlation coefficient was used for correlation studies. The Exponential Triple Smoothing estimator was used to estimate the number of articles expected to be published in the coming years. Results: A total of 3203 publications were found. 1863 (58.1%) of these publications were articles. The most active author is Gupta PJ. (n=26). The first 2 journals that published the most articles were Diseases of the Colon & Rectum (n=228) and Colorectal Disease (n=82). Singapore General Hospital (n=35) and University of Rome La Sapienza (n=19) were the 2 most active institutions. According to the average number of citations per article, the top 2 most influential journals were British Journal of Surgery and American Journal of Gastroenterology. Conclusion: In this comprehensive study on hemorrhoids, a statistical analysis of 1863 articles was shared. It was determined that the trend topics in hemorrhoid researches were THD, mucopexy, transanal hemorrhoidal dearterialization, colorectal surgery, embolization, constipation, risk factors, Milligan-Morgan, classification, recurrence and randomized controlled trial. This article can be a useful resource for scientists and clinicians in terms of the global output of hemorrhoids yesterday, today and tomorrow.
{"title":"The evolution of hemorrhoids publications during 1980-2021: a global and medical view with bibliometric analysis","authors":"İsmail Sezi̇kli̇, Orhan Aslan, R. Topcu","doi":"10.38053/acmj.1263215","DOIUrl":"https://doi.org/10.38053/acmj.1263215","url":null,"abstract":"Aims: Hemorrhoids is a common anorectal disorder and significantly affects quality of life. Although the number of global studies on hemorrhoids has increased in recent years, there is still no bibliometric study in the literature. In this study, it aimed that analyzing the scientific articles published on hemorrhoids holistically. \u0000Methods: The articles published between 1980 and 2021 were analyzed using bibliometric and statistical methods on hemorrhoids. Network visualization maps were used to identify trending topics and international collaborations. Spearman’s correlation coefficient was used for correlation studies. The Exponential Triple Smoothing estimator was used to estimate the number of articles expected to be published in the coming years. \u0000Results: A total of 3203 publications were found. 1863 (58.1%) of these publications were articles. The most active author is Gupta PJ. (n=26). The first 2 journals that published the most articles were Diseases of the Colon & Rectum (n=228) and Colorectal Disease (n=82). Singapore General Hospital (n=35) and University of Rome La Sapienza (n=19) were the 2 most active institutions. According to the average number of citations per article, the top 2 most influential journals were British Journal of Surgery and American Journal of Gastroenterology. \u0000Conclusion: In this comprehensive study on hemorrhoids, a statistical analysis of 1863 articles was shared. It was determined that the trend topics in hemorrhoid researches were THD, mucopexy, transanal hemorrhoidal dearterialization, colorectal surgery, embolization, constipation, risk factors, Milligan-Morgan, classification, recurrence and randomized controlled trial. This article can be a useful resource for scientists and clinicians in terms of the global output of hemorrhoids yesterday, today and tomorrow.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129166713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatih SAHİN, Erhan AKTÜRK, Osman Samet GÜNKAYA, Savaş ÖZDEMİR, Merve KONAL, Simten GENÇ, Arzu YURCİ, Ozgur AKBAYİR
Aims: To investigate whether there is a difference between serum tumor markers panel (CA 125, CA 19-9, CA 15-3, and carcinoembryonic antigen (CEA)) and tumor size and histopathology in well-staged patients with borderline ovarian tumors (BOTs).
Methods: Over the past 20 years (January 2001 to January 2021), the results of four tumor markers (CA 125, CA 19-9, CA 15-3, and carcinoembryonic antigen (CEA)) have been clinically analyzed for for this retrospective cohort study of 156 patients who underwent surgery and were diagnosed with histopathology consistent with a borderline ovarian tumor.
Results: The average age of patients with borderline ovarian tumors was determined to be 51.67 (4.726) years. Before the first surgery, high CA 125 levels (>35 U/l) were found in 53 patients (34%), high CEA levels (>4 ng/ml) were found in 24 patients (15.4%), high CA 19-9 levels (>37 U/ml) were found in 29 patients (18.6%), and high CA 15-3 (>30 ng/ml) levels were found in 12 patients (7.7%). The average CA 125 levels in tumors with serous histopathology [372.8 (1805.2)] were higher than those in tumors with mucinous histopathology (p=0.006). There was no statistically significant difference in tumor markers between tumors smaller than 8 cm and larger than 8 cm [(CA 125 p=0,257), (CEA p=0.9), (CA 19-9 p=0.295), (CA 15-3 p=0.404)].
Conclusion: Our primary outcome of the study is an increase in CA 125 levels, which indicates serous histopathology. Our secondary outcome is the higher levels of tumor markers, but it does not suggest larger tumors.
{"title":"Borderline ovarian tumors: twenty years of experience at a tertiary center","authors":"Fatih SAHİN, Erhan AKTÜRK, Osman Samet GÜNKAYA, Savaş ÖZDEMİR, Merve KONAL, Simten GENÇ, Arzu YURCİ, Ozgur AKBAYİR","doi":"10.38053/acmj.1243317","DOIUrl":"https://doi.org/10.38053/acmj.1243317","url":null,"abstract":"Aims: To investigate whether there is a difference between serum tumor markers panel (CA 125, CA 19-9, CA 15-3, and carcinoembryonic antigen (CEA)) and tumor size and histopathology in well-staged patients with borderline ovarian tumors (BOTs). 
 Methods: Over the past 20 years (January 2001 to January 2021), the results of four tumor markers (CA 125, CA 19-9, CA 15-3, and carcinoembryonic antigen (CEA)) have been clinically analyzed for for this retrospective cohort study of 156 patients who underwent surgery and were diagnosed with histopathology consistent with a borderline ovarian tumor.
 Results: The average age of patients with borderline ovarian tumors was determined to be 51.67 (4.726) years. Before the first surgery, high CA 125 levels (>35 U/l) were found in 53 patients (34%), high CEA levels (>4 ng/ml) were found in 24 patients (15.4%), high CA 19-9 levels (>37 U/ml) were found in 29 patients (18.6%), and high CA 15-3 (>30 ng/ml) levels were found in 12 patients (7.7%). The average CA 125 levels in tumors with serous histopathology [372.8 (1805.2)] were higher than those in tumors with mucinous histopathology (p=0.006). There was no statistically significant difference in tumor markers between tumors smaller than 8 cm and larger than 8 cm [(CA 125 p=0,257), (CEA p=0.9), (CA 19-9 p=0.295), (CA 15-3 p=0.404)].
 Conclusion: Our primary outcome of the study is an increase in CA 125 levels, which indicates serous histopathology. Our secondary outcome is the higher levels of tumor markers, but it does not suggest larger tumors.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135601505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Identifying prognostic markers in advanced small-cell lung cancer (A-SCLC) patients is important. Therefore, our study aimed to evaluate the prognostic value of pretreatment lung immune prognostic index (LIPI) in A-SCLC. Methods: This was a retrospective and observational study of A-SCLC patients treated with platinum plus etoposide chemotherapy as first-line treatment. The association of LIPI with progression-free survival (PFS) and overall survival (OS) was analysed. Results: One hundred eighteen patients were included in this study and divided into three groups LIPI 0 (n=27, 22.9%), LIPI 1 (n=57, 48.3%) and LIPI 2 (n=34, 28.8%). The median PFS of LIPI groups (0/1/2) was 8.9 (95% CI 3.83-13.96), 8 (95% CI 6.41-9.58), and 5.6 (95% CI 4.60-6.60) months, respectively (p=0.1) The median OS of LIPI groups (0/1/2) was 12 (95% CI 9.11-14.88), 10.1 (95% CI 9.16-11.03), and 7.7 (95% CI 6.55-8.84) months, respectively (p=0.02). Cox regression analysis revealed that LIPI 2 score was an independent risk factor for both PFS (HR 1.839, 95% CI: 1.075-3.144, p=0.02) and OS (HR 1.757, 95% CI: 1.006-3.071, p=0.04). Conclusion: LIPI score can be used as a simple and easily accessible marker to predict prognosis for A-SCLC patients.
{"title":"Lung immune prognostic index as a prognostic predictor in patients with advanced small cell lung cancer","authors":"Y. Söyler, Pınar Akın Kabalak, Suna Kavurgacı, Merve Ayyürek, Ayperi Öztürk, Ülkü Yılmaz","doi":"10.38053/acmj.1259381","DOIUrl":"https://doi.org/10.38053/acmj.1259381","url":null,"abstract":"Aims: Identifying prognostic markers in advanced small-cell lung cancer (A-SCLC) patients is important. Therefore, our study aimed to evaluate the prognostic value of pretreatment lung immune prognostic index (LIPI) in A-SCLC. \u0000Methods: This was a retrospective and observational study of A-SCLC patients treated with platinum plus etoposide chemotherapy as first-line treatment. The association of LIPI with progression-free survival (PFS) and overall survival (OS) was analysed. \u0000Results: One hundred eighteen patients were included in this study and divided into three groups LIPI 0 (n=27, 22.9%), LIPI 1 (n=57, 48.3%) and LIPI 2 (n=34, 28.8%). The median PFS of LIPI groups (0/1/2) was 8.9 (95% CI 3.83-13.96), 8 (95% CI 6.41-9.58), and 5.6 (95% CI 4.60-6.60) months, respectively (p=0.1) The median OS of LIPI groups (0/1/2) was 12 (95% CI 9.11-14.88), 10.1 (95% CI 9.16-11.03), and 7.7 (95% CI 6.55-8.84) months, respectively (p=0.02). Cox regression analysis revealed that LIPI 2 score was an independent risk factor for both PFS (HR 1.839, 95% CI: 1.075-3.144, p=0.02) and OS (HR 1.757, 95% CI: 1.006-3.071, p=0.04). \u0000Conclusion: LIPI score can be used as a simple and easily accessible marker to predict prognosis for A-SCLC patients.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124835454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İ. Aral, Gonca Altınısık Inan, Fatma Betül Ayrak, Feyza YAŞAR DAŞGIN, N. Aslan, Yillar Lehi̇mci̇oğlu, Fatma Yildirim, M. Akinci, Y. Tezcan
Aims: In this study, we aimed to evaluate the outcomes of thymoma patients who underwent radiotherapy (RT). Methods: Data from thymoma patients who underwent RT at Ankara Bilkent City Hospital, Ankara Atatürk Education and Research Hospital and Ankara Numune Education and Research Hospital were analysed retrospectively. The primary endpoints of this study were acute and late side effects and the secondary endpoints were overall survival(OS) and disease-free survival(DFS). Results: Data from 22 patients who received RT between 10.03.2008 and 05.10.2022 were analysed.The median follow-up time was 33 months (range: 1–76). RT-related acute toxicity was observed in 6 patients(27.3%). Late RT-related toxicity was noted in 4 patients (18%). As a late toxicity one patient (4.5%) had a secondary malignancy five years after RT.Patients younger than 40 years of age had significantly higher acute (p=0.039) and late (p=0.01) toxicity. Recurrence was observed in 7 patients (31.8%). The median DFS was 13 months (range: 1–176),the 1-year DFS was 58%, the 5-year DFS was 23%. Lower DFS was observed in patients with myasthenia gravis (MG) (p=0.018). Six patients(27.3%) died, the median OS was 33 months (range: 1–176),the 1-year OS was 84.4%, the 5-year OS was 76.7%. There was a significant correlation between performans status and OS (p=0.047). Conclusion: Side effects were more frequently observed in patients younger than 40 years of age. Poor prognostic factors were identified as MG for DFS and poor performance status for OS. Thymoma patients have high OS, studies are needed to identify subgroups that do not require RT.
{"title":"Thymoma radiotherapy: a retrospective multicentre study","authors":"İ. Aral, Gonca Altınısık Inan, Fatma Betül Ayrak, Feyza YAŞAR DAŞGIN, N. Aslan, Yillar Lehi̇mci̇oğlu, Fatma Yildirim, M. Akinci, Y. Tezcan","doi":"10.38053/acmj.1298365","DOIUrl":"https://doi.org/10.38053/acmj.1298365","url":null,"abstract":"Aims: In this study, we aimed to evaluate the outcomes of thymoma patients who underwent radiotherapy (RT). \u0000Methods: Data from thymoma patients who underwent RT at Ankara Bilkent City Hospital, Ankara Atatürk Education and Research Hospital and Ankara Numune Education and Research Hospital were analysed retrospectively. The primary endpoints of this study were acute and late side effects and the secondary endpoints were overall survival(OS) and disease-free survival(DFS). \u0000Results: Data from 22 patients who received RT between 10.03.2008 and 05.10.2022 were analysed.The median follow-up time was 33 months (range: 1–76). RT-related acute toxicity was observed in 6 patients(27.3%). Late RT-related toxicity was noted in 4 patients (18%). As a late toxicity one patient (4.5%) had a secondary malignancy five years after RT.Patients younger than 40 years of age had significantly higher acute (p=0.039) and late (p=0.01) toxicity. Recurrence was observed in 7 patients (31.8%). The median DFS was 13 months (range: 1–176),the 1-year DFS was 58%, the 5-year DFS was 23%. Lower DFS was observed in patients with myasthenia gravis (MG) (p=0.018). Six patients(27.3%) died, the median OS was 33 months (range: 1–176),the 1-year OS was 84.4%, the 5-year OS was 76.7%. There was a significant correlation between performans status and OS (p=0.047). \u0000Conclusion: Side effects were more frequently observed in patients younger than 40 years of age. Poor prognostic factors were identified as MG for DFS and poor performance status for OS. Thymoma patients have high OS, studies are needed to identify subgroups that do not require RT.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"97 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114134337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sakine Nazik Bahçecioğlu, H. Ateş, İ. Koca Kalkan, K. Aksu, Ş. Demi̇r, M. Topel, S. Yeşi̇lkaya
Aims: Inspiratory particle load including the allergens in the inhaled air is decreased by the use of the mask, which is one of the methods for COVID-19 protection. The aim of the study is to investigate the effect of masks used by seasonal allergic rhinitis patients with pollen allergy on the control of rhinitis symptoms. Methods: Mask usage characteristics of patients (mask type used, average number of days per week for mask usage, daily usage time),whether there was a change in the time spent outdoors during the pandemic compared to the pre-pandemic period, and rhinitis complaints and frequency of rhinitis-related drug use before the pandemic compared to the pandemic period were investigated. Results:The frequency of nasal discharge (6.62±1.69; 6.00±1.89: p
{"title":"The effect of mask use on allergic rhinitis symptoms during COVID-19 pandemic","authors":"Sakine Nazik Bahçecioğlu, H. Ateş, İ. Koca Kalkan, K. Aksu, Ş. Demi̇r, M. Topel, S. Yeşi̇lkaya","doi":"10.38053/acmj.1313818","DOIUrl":"https://doi.org/10.38053/acmj.1313818","url":null,"abstract":"Aims: Inspiratory particle load including the allergens in the inhaled air is decreased by the use of the mask, which is one of the methods for COVID-19 protection. The aim of the study is to investigate the effect of masks used by seasonal allergic rhinitis patients with pollen allergy on the control of rhinitis symptoms. \u0000Methods: Mask usage characteristics of patients (mask type used, average number of days per week for mask usage, daily usage time),whether there was a change in the time spent outdoors during the pandemic compared to the pre-pandemic period, and rhinitis complaints and frequency of rhinitis-related drug use before the pandemic compared to the pandemic period were investigated. \u0000Results:The frequency of nasal discharge (6.62±1.69; 6.00±1.89: p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"266 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114346674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: In this study, we aimed to evaluate the relationship between sleep disorder and serum tau protein levels in children with cerebral palsy. Methods: The sample was selected among children aged 6-10 years who applied to our physical medicine and rehabilitation outpatient clinic. In order to evaluate sleep quality, the Pittsburgh Sleep Quality Index (PSQI) questionnaire was recorded by asking parents of all participants. Children with CP who had a Pittsburgh Sleep Quality Index value above 5 were determined as the sleep disorder group. We recruited 27 children with CP and sleep disorders in the first patient group (Group 1), 27 children with CP but without sleep disorders in the second group (Group 2). The third group (Group 3), which was the healthy group, included 27 children without any disease. We also recorded the age of children at diagnosis, risk factors for CP (premature, prolonged birth, etc.), CP type, gross motor function classification system (GMFCS), botox application, orthoses usage, maternal age at birth, and additional problems. We measured total tau protein (T-tau) and phosphorylated tau protein (P-tau) levels in blood samples through a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). The correlation between tau protein and PSQI values was examined. Results: Maternal age (p=0.001), gross motor function classification system (GMFCS) (p=0.001), and pittsburgh sleep quality index (PSQI) (p=0.001) were significantly higher in the group with sleep disorders. There was a statistically significant difference between the groups in terms of serum T-Tau and P-tau protein levels (T-tau p=0.003, P-tau p=0.004). In the group sleep disorders, PSQI was significantly correlated with T-tau (r=0.499) and P-tau (r=0.473). Conclusion: This study shows that tau protein levels are higher in CP patients with sleep disorders than in participants without sleep disorders. In the correlation analyzes, a positive and significant correlation was observed between PSQI values and T-tau and P-tau in sleep disorders groups, and no correlation was found in without sleep disorders.
{"title":"Tau protein hyperphosphorylation in children with cerebral palsy with sleep disorders","authors":"A. Doğan, Ihsan Cetin","doi":"10.38053/acmj.1309367","DOIUrl":"https://doi.org/10.38053/acmj.1309367","url":null,"abstract":"Aims: In this study, we aimed to evaluate the relationship between sleep disorder and serum tau protein levels in children with cerebral palsy. \u0000Methods: The sample was selected among children aged 6-10 years who applied to our physical medicine and rehabilitation outpatient clinic. In order to evaluate sleep quality, the Pittsburgh Sleep Quality Index (PSQI) questionnaire was recorded by asking parents of all participants. Children with CP who had a Pittsburgh Sleep Quality Index value above 5 were determined as the sleep disorder group. We recruited 27 children with CP and sleep disorders in the first patient group (Group 1), 27 children with CP but without sleep disorders in the second group (Group 2). The third group (Group 3), which was the healthy group, included 27 children without any disease. We also recorded the age of children at diagnosis, risk factors for CP (premature, prolonged birth, etc.), CP type, gross motor function classification system (GMFCS), botox application, orthoses usage, maternal age at birth, and additional problems. We measured total tau protein (T-tau) and phosphorylated tau protein (P-tau) levels in blood samples through a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). The correlation between tau protein and PSQI values was examined. \u0000Results: Maternal age (p=0.001), gross motor function classification system (GMFCS) (p=0.001), and pittsburgh sleep quality index (PSQI) (p=0.001) were significantly higher in the group with sleep disorders. There was a statistically significant difference between the groups in terms of serum T-Tau and P-tau protein levels (T-tau p=0.003, P-tau p=0.004). In the group sleep disorders, PSQI was significantly correlated with T-tau (r=0.499) and P-tau (r=0.473). \u0000Conclusion: This study shows that tau protein levels are higher in CP patients with sleep disorders than in participants without sleep disorders. In the correlation analyzes, a positive and significant correlation was observed between PSQI values and T-tau and P-tau in sleep disorders groups, and no correlation was found in without sleep disorders.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130688409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Fluid overloaded patients with heart or renal insufficiency have poor quality of life and increased morbidity and mortality. In this study, we aimed to investigate the factors affecting the prognosis in patients who presented with fluid overload and were ultrafiltered. Methods: Three groups of patients were compared: Group 1: Patients with chronic kidney disease and ejection fraction ≤ 40%; Group 2: Patients with chronic kidney disease and ejection fraction > 40%; Group 3: Patients with ejection fraction ≤ 40% but without chronic kidney disease. Patients were also evaluated regarding mortality. Results: Group 1, 2 and 3 consisted of 14, 62 and 16 patients: respectively. There were statistically significant results for 24-hour urine volume (p=0.040), proteinuria (p=0.010), ultrafiltration volume/weight at hospitalization (p
{"title":"Evaluation of ultrafiltrated fluid overloaded patients: a single center study","authors":"Ö. Can, Süleyman Baş, G. Şahi̇n, S. Apaydın","doi":"10.38053/acmj.1254921","DOIUrl":"https://doi.org/10.38053/acmj.1254921","url":null,"abstract":"Aims: Fluid overloaded patients with heart or renal insufficiency have poor quality of life and increased morbidity and mortality. In this study, we aimed to investigate the factors affecting the prognosis in patients who presented with fluid overload and were ultrafiltered. \u0000Methods: Three groups of patients were compared: Group 1: Patients with chronic kidney disease and ejection fraction ≤ 40%; Group 2: Patients with chronic kidney disease and ejection fraction > 40%; Group 3: Patients with ejection fraction ≤ 40% but without chronic kidney disease. Patients were also evaluated regarding mortality. \u0000Results: Group 1, 2 and 3 consisted of 14, 62 and 16 patients: respectively. There were statistically significant results for 24-hour urine volume (p=0.040), proteinuria (p=0.010), ultrafiltration volume/weight at hospitalization (p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126528790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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