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Distinct Effects of Topical Nitroglycerol on Brain Delivery of Free and Nanoparticle-Bound Drugs in Rodents 局部硝酸甘油对啮齿动物游离和纳米颗粒结合药物脑递送的不同影响
RAN
Pub Date : 2017-04-01 DOI: 10.11159/NDDTE17.109
A. Alekseeva, A. Khalansky, O. Maksimenko, N. Osipova, K. Abbasova, J. Kreuter, S. Gelperina
1 Research Institute of Human Morphology, Cjurupy st. 3, Moscow, 117418, Russia 2 Drugs Technology Ltd., Rabochaya st. 2a, Khimki, Moscow region, 141400, Russia 3 Lomonosov Moscow State University, Faculty of Biology 1-12 Leninskie Gory, Moscow, 119991, Russia 4 Institute of Pharmaceutical Technology, Goethe University Marie-Curie-Str. 9, Frankfurt am Main, 60439, Germany mariott@bk.ru; svetlana.gelperina@gmail.com
1 .人类形态学研究所,莫斯科,117418;2 .药物技术有限公司,莫斯科地区,希姆基,Rabochaya街2a, 141400; 3 .罗蒙诺索夫莫斯科国立大学,生物系1-12,莫斯科,119991;4 .歌德大学玛丽居里大街制药技术研究所。9、德国法兰克福60439 mariott@bk.ru;svetlana.gelperina@gmail.com
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引用次数: 0
In Silico Studies of the Mechanical Stimuli within Bone Tissue and Bone-Tissue-Engineered-Scaffolds 骨组织和骨组织工程支架内机械刺激的计算机研究
RAN
Pub Date : 2017-04-01 DOI: 10.11159/NDDTE17.1
C. Sandino
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引用次数: 0
Synthesis and Characterization of NIR Dye-Doped Nanoparticles for in Vivo Tumor Diagnostics 用于体内肿瘤诊断的近红外染料掺杂纳米颗粒的合成与表征
RAN
Pub Date : 2017-04-01 DOI: 10.11159/nddte17.105
Christine Schneider, S. Dembski
Christine Schneider, Sofia Dembski 3 University Hospital of Wuerzburg Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany christine.b.schneider@uni-wuerzburg.de Fraunhofer Institute for Silicate Research Institute ISC Neunerplatz 2, 97082 Wuerzburg, Germany Translational Center Wuerzburg, Regenerative Therapies in Oncology and Musculoskeletal Diseases Roentgenring 11, 97070 Wuerzburg, Germany sofia.dembski@fraunhofer.isc.de
3维尔茨堡约瑟夫-施耐德街大学医院。297080维尔茨堡,德国christine.b.schneider@uni-wuerzburg.de Fraunhofer硅酸盐研究所ISC Neunerplatz 2,97082维尔茨堡,德国维尔茨堡转化中心,肿瘤和肌肉骨骼疾病的再生治疗伦琴11,97070维尔茨堡,德国sofia.dembski@fraunhofer.isc.de
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引用次数: 0
Sub-microns NaCl-TiO2 Particles to Improve the Rain Enhancement as Cloud Seeding 亚微米NaCl-TiO2粒子在人工增雨中的应用
RAN
Pub Date : 2017-04-01 DOI: 10.11159/ICNEI17.105
N. E. Hadri, A. Zaki, M. Vargas, L. Zou, M. Jouiad
Extended Abstract The water scarcity in the arid region is a real concern to consider in near future. For instance, the United Arab Emirates accounts for 110 mm as the average annual rainfall, which is restricting the abundance of groundwater originating from the rainfall. Hence, there is an urgent need to look for an alternative to increase water levels to satisfy the continual growth of human and industrial needs. A promising alternative that becomes more achievable due the late technologies development is the use of cloud seeding particles to enhance the rainfall [1]. Indeed, cloud seeding is a process that allows altering the weather by the insertion of a material into the clouds in order to trigger the formation and the growth of droplets, once the water droplets are big enough they will fall due to gravity participating in the enhancement of rainfall. Basically, clouds are composed of dust particles and condensed water and the thermodynamic conditions for the formation of the droplets happened with the nucleation by aerosol particles [2]. There are two cloud seeding methods: hygroscopic cloud seeding and glaciogenic cloud seeding. In hygroscopic cloud seeding (warm clouds), it implicates the addition of salt crystals to attract water droplets and promote collision-coalescence process to form bigger droplets [3]. In glaciogenic seeding (cold clouds), it implicates the addition of particles to the cool clouds (water is below the freezing point) in order to form ice crystals, which will grow and fall. Silver iodide is used for glaciogenic cloud seeding because its form is similar to ice crystals. In this present study, new nanomaterials were used in order to obtain a high performance for hygroscopic cloud seeding. Optimized NaCl cubic crystals with a size of 1 μm were used to prepare sub-micron NaCl/TiO2. The NaCl/TiO2 were evaluated by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction, Raman spectroscopy and water vapor sorption. SEM will be used in order to observe the shape and the size of the NaCl and NaCl/TiO2 particles. TEM, XRD and Raman were used in order to make in evidence the presence of the TiO2 coating on the NaCl salt crystals surface. Figure 1 gives the SEM image of the composite crystals used in this study. They have cubic like shape.
干旱地区的水资源短缺问题在不久的将来是一个值得关注的问题。例如,阿联酋的年平均降雨量为110毫米,这限制了降雨产生的地下水的丰富程度。因此,迫切需要寻找一种替代方案来增加水位,以满足人类和工业需求的持续增长。由于后期技术的发展,一种有希望的替代方案变得更容易实现,即使用云播粒子来增强降雨[1]。事实上,云播是一种通过在云中插入一种物质来改变天气的过程,以触发水滴的形成和增长,一旦水滴足够大,它们就会由于重力参与降雨的增强而下降。云基本上是由尘粒和凝结水组成的,液滴形成的热力学条件是伴随着气溶胶粒子的成核而发生的[2]。有两种播云方法:吸湿性播云和冰川性播云。在吸湿云(暖云)中,通过添加盐晶体来吸引水滴,促进碰撞聚结过程,形成更大的水滴[3]。在冰期播种(冷云)中,它意味着向冷云(水在冰点以下)中添加粒子,以形成冰晶,冰晶会生长和下降。碘化银因其形态与冰晶相似而被用于冰期造云。在本研究中,为了获得高性能的吸湿云播种,使用了新型纳米材料。采用优化后尺寸为1 μm的NaCl立方晶体制备亚微米NaCl/TiO2。采用扫描电镜(SEM)、透射电镜(TEM)、x射线衍射(xrd)、拉曼光谱(Raman spectroscopy)和水蒸气吸附(water vapor absorption)对NaCl/TiO2进行了表征。利用扫描电镜观察NaCl和NaCl/TiO2颗粒的形状和大小。利用透射电镜、XRD和拉曼光谱等手段证实了TiO2涂层在NaCl盐晶体表面的存在。图1给出了本研究中使用的复合晶体的SEM图像。它们有立方体的形状。
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引用次数: 1
Layered Montmorillonite Mineral Clay Used for Controlled Insulin Release 层状蒙脱石矿物粘土用于控制胰岛素释放
RAN
Pub Date : 2017-04-01 DOI: 10.11159/ICNNFC17.145
M. Sonmez, Ficai Denisa, Ficai Anton, Trusca Roxana, D. Gurau
Sonmez Maria, Ficai Denisa, Ficai Anton, Trusca Roxana, Dana Florentina Gurau Research Institute of the University of Bucharest 36-46 Bd. M. Kogalniceanu, Bucharest, Romania ficaimaria@yahoo.com Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science 1-7 Polizu St., Bucharest, Romania denisaficai@yahoo.ro; anton.ficai@upb.ro; S.C. METAV R&D S.A 31 C.A. Rosetti str., Bucharest, Romania truscaroxana@yahoo.com National Research & Development Institute for Textiles and Leather–division: Leather and Footwear Research Institute 93 Ion Minulescu St., Bucharest, Romania dana.gurau@icpi.ro
Sonmez Maria, Ficai Denisa, Ficai Anton, Trusca Roxana,布加勒斯特大学Dana Florentina Gurau研究所36-46 Bd. M. Kogalniceanu,布加勒斯特,罗马尼亚ficaimaria@yahoo.com布加勒斯特Politehnica大学应用化学与材料科学学院1-7 Polizu St,布加勒斯特,罗马尼亚denisaficai@yahoo.ro;anton.ficai@upb.ro;S.C. METAV R&D S.A 31 C.A. Rosetti街,布加勒斯特,罗马尼亚truscaroxana@yahoo.com国家纺织和皮革研究与发展研究所分部:皮革和鞋类研究所93 Ion Minulescu街,布加勒斯特,罗马尼亚dana.gurau@icpi.ro
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引用次数: 0
Computational Study on the Nanotubes Formation between Olsalazine and -Cyclodextrin 奥萨拉嗪与-环糊精形成纳米管的计算研究
RAN
Pub Date : 2017-04-01 DOI: 10.11159/ICNMS17.101
A. Bani-Yaseen
Extended Abstract Interests in cyclodextrin-derived nano-assembled supramolecular systems have recently grown notably [1,2]. Cyclodextrins are a family of oligosaccharides that possess very characteristic features of conical shape with hydrophobic and hydrophilic interiors and exteriors, respectively. As a host molecule, cyclodextrin (CD) can encapsulate various types of molecules inside its cavity as host-guest supramolecular interaction that is in turn stabilized by non-covalent interactions [3-5]. Under specific conditions, cyclodextrins can self-aggregate to form nanoarchitectures, such as nanotubes and nanorods. However, guest-induced nanotubular architecture can be assembled with gust molecules of suitable size, such as olsalazine drug. The objective of this work is to computationally investigate the formation and the corresponding molecular properties of olsalazine--CD nanotubes using the semi-empirical method (SQM) PM7. Different guest:host ratios of inclusion complexes that can lead to the formation of the olsalazine--CD nanotubes were examined, namely 1:2 and 2:2. Furthermore, the side of penetration of the guest molecule is another factor that is considered herein, where head and tail inclusions correspond to the penetration inside the cavity of -CD through the wide and narrow rims of -CD, respectively. On the other hand, the head-to-head, tail-to-tail, head-to-tail aggregations of -CD nanotubes are considered. The binding energy (Ebind) of the nano suprastructure was calculated using the following formula:
对环糊精衍生的纳米组装超分子体系的兴趣最近显著增长[1,2]。环糊精是一类低聚糖,具有非常独特的圆锥形特征,内部和外部分别具有疏水性和亲水性。环糊精(cyclodextrin, CD)作为宿主分子,可以将各种类型的分子封装在其空腔内,形成主客体超分子相互作用,并通过非共价相互作用稳定[3-5]。在特定条件下,环糊精可以自聚集形成纳米结构,如纳米管和纳米棒。然而,客人诱导的纳米管结构可以与适当大小的客人分子组装,例如奥萨拉嗪药物。本工作的目的是利用半经验方法(SQM) PM7计算研究奥萨拉嗪-- cd纳米管的形成和相应的分子性质。研究了不同客体:主体比例的包裹体可导致奥萨拉嗪-- cd纳米管的形成,即1:2和2:2。此外,客体分子穿透的侧面是本文考虑的另一个因素,其中头部和尾部包裹体分别对应于通过-CD的宽边缘和窄边缘在-CD的腔内的穿透。另一方面,考虑了-CD纳米管的头对头、尾对尾、头对尾聚集。纳米超结构的结合能(Ebind)由下式计算:
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引用次数: 0
3D Printed Human Auricular Model for Tissue Engineering 用于组织工程的3D打印人体耳廓模型
RAN
Pub Date : 2017-04-01 DOI: 10.11159/nddte17.114
E. Gökçe, Armağan Yalgın, D. E. Tapınç, F. Aydın
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引用次数: 0
Combined Experimental and Computational Approach to Develop Efficient Photocatalysts Based on RE-TiO2 Nanoparticles 基于RE-TiO2纳米粒子的高效光催化剂的实验与计算相结合研究
RAN
Pub Date : 2017-04-01 DOI: 10.11159/ICNMS17.107
A. Mikołajczyk, Joanna Nadolna, Adriana Zalewska-Medynska, T. Puzyn
Extended Abstract Taking into consideration the current socioeconomical and environmental situation, new environmentally friendly and efficient nanomaterials that can degrade organic pollutants are needed. Semiconductor-based heterogeneous photocatalysis is a versatile, low-cost, clean and environmentally benign treatment technology for a variety of pollutants. Of high interest are TiO2-based nanomaterials, which can offer promising avenues for innovative applications such as environmentally friendly photocatalysts. It has been demonstrated to promote the decomposition of a variety of organic and inorganic compounds in both the gas and liquid phases, prompting its potential application in sterilization, sanitation and air and water purification systems. A serious drawback of TiO2 is that it can only be excited by ultraviolet light (<5% of the solar irradiation) due to its relatively large band gap (about 3.2 eV). Therefore, development of visible light (Vis) active photocatalysts to efficiently utilize solar energy is both an important and challenging research field. Reactivity of TiO2 in visible light (λ>400 nm) can be achieved in several ways, including metal doping or surface modification by earth raremetal nanopraticles (RE). This study has demonstrated for the first time the potential benefits of using computational approach supporting experimental methods to obtain predictive knowledge on structural features of Re-TiO2 nanotubes (RE-NTs) that may govern their photocatalytic activity under visible light. In this work, the influence of the type of rare metal (Re) on the electronica properties as well as on their photocatalytic activity, were investigated by combined experimental–theoretical approach. RE-NTs was prepared via an electrochemical method. The RE-NTs photocatalysts were characterized experimentally (i.e. by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), UV–Vis absorption, scanning electron microscopy (SEM) and luminescent spectroscopy)). The obtained results indicated that toluene in the gas phase was successfully degraded under visible light (LEDs λmax= 465 nm) using RE-NTs. Based on experimentally obtained results we selected most active sample (Ho-NTs). To investigate the electronic properties that can be responsible for higher photocatalytic activity of surface modified Ho-NTs computer simulations were performed. Molecular models of Ho-NTs were optimized using the plane-wave-based Vienna ab-initio simulation package (VASP) implementing spin-polarized density-functional theory (DFT) and the generalized gradient approximation (GGA). Based on experimental result (supported by computational methods) is proposed that during the electrochemical process, TiO2 systems with new Ho-f states below the conduction band of TiO2 is formed. The photocatalytic activity under Vis irradiation is attributable not to •OH but to other forms of reactive oxygen species (O2•−, HO2•, H2O2). It should be highlighted, that the methodolog
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引用次数: 0
Layered Composites Based on Recycled PET/Functionalized Woven Flax Fibres 基于再生PET/功能化亚麻织物的层状复合材料
RAN
Pub Date : 2017-04-01 DOI: 10.11159/icnnfc17.144
M. Sonmez, L. Alexandrescu, M. Nițuică, M. Georgescu, Florentina Dana Gurau, D. Ficai, A. Ficai, R. Trusca, D. Constantinescu
Sönmez Maria, Alexandrescu Laurentia, Nituica Mihaela, Georgescu Mihai, Gurau Florentina Dana, Ficai Denisa, Ficai Anton, Trusca Roxana, Constantinescu Doina National Research and Development Institute for Textiles and Leather–division Leather and Footwear Research Institute 93 Ion Minulescu St., Bucharest, Romania maria.sonmez@icpi.ro; laurentia.alexandrescu@icpi.ro; mihaela.nituica@icpi.ro; mihai.georgescu@icpi.ro; dana.gurau@icpi.ro Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science 1-7 Polizu St., Bucharest, Romania denisa.ficai@yahoo.ro; anton.ficai@upb.ro; truscaroxana@yahoo.com SC MONOFIL S.R.L 1 Uzinei St., Savinesti, Romania monofil.srl@gmail.com
Sönmez Maria, Alexandrescu Laurentia, Nituica Mihaela, Georgescu Mihai, Gurau Florentina Dana, Ficai Denisa, Ficai Anton, Trusca Roxana, Constantinescu Doina国家纺织和皮革研究与发展研究所皮革和鞋类研究所93 Ion Minulescu St.,布加勒斯特,罗马尼亚maria.sonmez@icpi.ro;laurentia.alexandrescu@icpi.ro;mihaela.nituica@icpi.ro;mihai.georgescu@icpi.ro;dana.gurau@icpi.ro布加勒斯特Politehnica大学应用化学与材料科学学院,布加勒斯特Polizu街1-7号,罗马尼亚denisa.ficai@yahoo.ro;anton.ficai@upb.ro;truscaroxana@yahoo.com SC MONOFIL S.R.L 1 Uzinei St, Savinesti,罗马尼亚monofil.srl@gmail.com
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引用次数: 2
Conformable Electronics: Recent Developments towards RobustPrinted Devices 兼容电子学:鲁棒印刷设备的最新发展
RAN
Pub Date : 2017-04-01 DOI: 10.11159/ICNNFC17.2
C. Simão
Printed Electronics technology and hybrid devices have the potential to combine compact high-performance circuit integration on thin, flexible and elastic substrates. Reliability and robustness of hybrid printed electronics is a major challenge for the implementation of the technology in practical applications such as flexible displays, smart labels, photovoltaic devices, sensing devices, and radio frequency identification (RFID) tags. Particularly, interfaces between the rigid components and the soft substrates represent the major issue due to mechanical incompatibility. Our recent work has focused on overcoming this drawback, by emphasizing the study of materials elasticity role and their deposition process, both for inks, adhesives and encapsulants. Furthermore, this strategy settles the direction towards conformable devices, by promoting stretchability up to elasticity. In this talk, materials, including substrates, conductive inks, based on silver or carbon nanoparticles, processing and curing and deposition techniques such as screen and inkjet printing in lab scale sheet to sheet up to pre-industrial roll to roll are discussed, in addition to recent developments in demonstrators ranging from conformable skin moisture sensor to LED hybrid elastic systems are presented, depicting processes and characterization involving electrical performance under mechanical strain and stability to ambient conditions.
印刷电子技术和混合器件具有在薄、柔性和弹性基板上结合紧凑的高性能电路集成的潜力。在柔性显示器、智能标签、光伏器件、传感器件和射频识别(RFID)标签等实际应用中,混合印刷电子器件的可靠性和鲁棒性是实现该技术的主要挑战。特别是,刚性元件和软基板之间的界面是由于机械不相容而产生的主要问题。我们最近的工作重点是克服这一缺点,通过强调研究材料的弹性作用及其沉积过程,包括油墨,粘合剂和密封剂。此外,该策略通过将可拉伸性提升到弹性,确定了面向兼容设备的方向。在这次演讲中,材料,包括基材,导电油墨,基于银或碳纳米颗粒,加工和固化和沉积技术,如丝网和喷墨印刷在实验室规模的片到片,直到工业化前的卷到卷,除了最近的发展,从符合皮肤湿度传感器到LED混合弹性系统展示。描述过程和特性,包括机械应变下的电气性能和环境条件的稳定性。
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引用次数: 0
期刊
RAN
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