Alpha (α) - asarone is known to be one of the active compounds which have been discovered to be responsible for the therapeutic benefits of Acorus species. Previous studies have reported that Acorus calamus leaf extracts exerted the neuromodulatory effects on the nigrostriatal dopaminergic system. Therefore, the present study aimed to investigate the antipsychotic-like activity of α-asarone using a mouse model of apomorphine-induced stereotyped behaviour. Swiss albino male mice (bodyweight, 25-30g) were used for this study. In acute studies, α-asarone at different doses 1, 10, 30, 50, and 100 mg/kg bodyweight were administered orally one hour prior to apomorphine (5mg/kg, i.p.) injection respectively. Immediately after the injection of apomorphine, the mice were placed individually in cylindrical metal cages (18 cm in diameter and 19 cm in height) with the wall and floor consisting of vertical and horizontal metal bars and recorded for climbing time and climbing behaviour. The climbing behaviour was scored as 4 = four paws on the wall of the cage, 2 = two paws on the wall of the cage, 0 = four paws on the floor. The acute treatment of α-asarone (1-100 mg/kg, p.o.) exhibited an inverted bell-shaped dose-response in cage climbing behaviour. α-asarone at 30 and 50 mg/kg significantly decreased the apomorphine-induced cage climbing time and climbing behaviour in mice. These observed effects might be attributed due to the antidopaminergic property of α-asarone. Antagonism of dopamine D2 receptors is a common feature of the most clinically effective antipsychotic drugs, especially active against hallucinations and delusions. Overall, the present study uncovered the antidopaminergic effect of α-asarone; thereby α-asarone exhibited antipsychotic-like activity in mice. However, further neurochemical studies are warranted to explore the actual mechanism of action of α-asarone as a promising novel antipsychotic agent.
{"title":"Antipsychotic-Like Activity of α-Asarone in Mice: A Preliminary Report","authors":"V. Pandy","doi":"10.23880/APCT-16000106","DOIUrl":"https://doi.org/10.23880/APCT-16000106","url":null,"abstract":"Alpha (α) - asarone is known to be one of the active compounds which have been discovered to be responsible for the therapeutic benefits of Acorus species. Previous studies have reported that Acorus calamus leaf extracts exerted the neuromodulatory effects on the nigrostriatal dopaminergic system. Therefore, the present study aimed to investigate the antipsychotic-like activity of α-asarone using a mouse model of apomorphine-induced stereotyped behaviour. Swiss albino male mice (bodyweight, 25-30g) were used for this study. In acute studies, α-asarone at different doses 1, 10, 30, 50, and 100 mg/kg bodyweight were administered orally one hour prior to apomorphine (5mg/kg, i.p.) injection respectively. Immediately after the injection of apomorphine, the mice were placed individually in cylindrical metal cages (18 cm in diameter and 19 cm in height) with the wall and floor consisting of vertical and horizontal metal bars and recorded for climbing time and climbing behaviour. The climbing behaviour was scored as 4 = four paws on the wall of the cage, 2 = two paws on the wall of the cage, 0 = four paws on the floor. The acute treatment of α-asarone (1-100 mg/kg, p.o.) exhibited an inverted bell-shaped dose-response in cage climbing behaviour. α-asarone at 30 and 50 mg/kg significantly decreased the apomorphine-induced cage climbing time and climbing behaviour in mice. These observed effects might be attributed due to the antidopaminergic property of α-asarone. Antagonism of dopamine D2 receptors is a common feature of the most clinically effective antipsychotic drugs, especially active against hallucinations and delusions. Overall, the present study uncovered the antidopaminergic effect of α-asarone; thereby α-asarone exhibited antipsychotic-like activity in mice. However, further neurochemical studies are warranted to explore the actual mechanism of action of α-asarone as a promising novel antipsychotic agent.","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129986799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adverse Effects of Ezapril in Rats","authors":"Alsadek Hb","doi":"10.23880/apct-16000165","DOIUrl":"https://doi.org/10.23880/apct-16000165","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"359 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122764031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How to Attach King Table Over Co-Worker Dislike Burnside Pharmacy Institute in Pune University Specialized Study","authors":"R. Hajare","doi":"10.23880/apct-16000180","DOIUrl":"https://doi.org/10.23880/apct-16000180","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116595644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood transfusion plays a vital role in the improvement of health and saves many lives. Haemovigilance system is the programme which ensures the transfusion safety by monitoring every step of transfusion process from donor to recipient. The ultimate object of haemovigilance system is improving the quality and safety of transfusion therapy. This article briefly describes about objective and reporting of the haemovigilance programme of India.
{"title":"An Overview on Haemovigilance Programme of India","authors":"Satyajeet Singh","doi":"10.23880/apct-16000183","DOIUrl":"https://doi.org/10.23880/apct-16000183","url":null,"abstract":"Blood transfusion plays a vital role in the improvement of health and saves many lives. Haemovigilance system is the programme which ensures the transfusion safety by monitoring every step of transfusion process from donor to recipient. The ultimate object of haemovigilance system is improving the quality and safety of transfusion therapy. This article briefly describes about objective and reporting of the haemovigilance programme of India.","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123873299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: We present two case reports of rare and aggressive presentation of multiple myeloma, one of the most common hematological malignancies. To our knowledge, there are very few case reports of meningeal invasion by multiple myeloma, denoting the importance of describing the clinical features and the complementary investigation necessary to develop a better approach to these patients. Cases presentation: In case 1, we present a 64 years old patient with vague symptoms of headache associated with exacerbated tendinous reflexes and previous diagnosis of multiple myeloma. In case 2, a 58 years old presents with auricular plenitude, headache and encephalopathy, and a medical antecedent of multiple myeloma. Both were diagnosed with different sites of multiple myeloma central nervous system invasion, case 1 with predominant meningeal infiltration and case 2 with intraparenchymal infiltration. Conclusion: Analyzing these cases, we conclude that besides the rarity of the meningeal accometiment in myeloma patients compared to other hematological disorders, the identification of clinical signals and symptoms suggestive of this invasion is necessary to provide better health care to these patients.
{"title":"Central Nervous System Infiltration by Multiple Myeloma: Two Case Reports of a Rare Clinical Presentation","authors":"M. Alves da Silva","doi":"10.23880/apct-16000200","DOIUrl":"https://doi.org/10.23880/apct-16000200","url":null,"abstract":"Introduction: We present two case reports of rare and aggressive presentation of multiple myeloma, one of the most common hematological malignancies. To our knowledge, there are very few case reports of meningeal invasion by multiple myeloma, denoting the importance of describing the clinical features and the complementary investigation necessary to develop a better approach to these patients. Cases presentation: In case 1, we present a 64 years old patient with vague symptoms of headache associated with exacerbated tendinous reflexes and previous diagnosis of multiple myeloma. In case 2, a 58 years old presents with auricular plenitude, headache and encephalopathy, and a medical antecedent of multiple myeloma. Both were diagnosed with different sites of multiple myeloma central nervous system invasion, case 1 with predominant meningeal infiltration and case 2 with intraparenchymal infiltration. Conclusion: Analyzing these cases, we conclude that besides the rarity of the meningeal accometiment in myeloma patients compared to other hematological disorders, the identification of clinical signals and symptoms suggestive of this invasion is necessary to provide better health care to these patients.","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127772156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validation of Ewefa as Herbal Recipes for Reproductive Health Problems (Rhps) among the Yoruba of South-Western Nigeria","authors":"Aderemi S Ajala","doi":"10.23880/apct-16000167","DOIUrl":"https://doi.org/10.23880/apct-16000167","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132554411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Monkeypox Cannot Cause a Pandemic like COVID-19","authors":"M. Norizadeh","doi":"10.23880/apct-16000202","DOIUrl":"https://doi.org/10.23880/apct-16000202","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130254468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Vitro Antimicrobial Activity of Choline Effervescent Tablets against Some Pathogenic Bacteria and Fungi","authors":"Mofeed Al Nowihi","doi":"10.23880/apct-16000178","DOIUrl":"https://doi.org/10.23880/apct-16000178","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134501262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Methanol Extract of the Ripe Fruit Peels of Musa Paradisiaca on Some Haematological and Biochemical Indices in Male Wistar Rats","authors":"Edet Okon Akpanyung","doi":"10.23880/apct-16000154","DOIUrl":"https://doi.org/10.23880/apct-16000154","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115360706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abū l- ‘Alā’ Zuhr (c.1060-1131), known among other names as Abuleli, is one of the most important physicians from AlAndalus who wrote on pharmacology and medicine. He also is the main author in Occident on popular scientific knowledge, as is Al-Majūsī (d.994) in Orient. Among his works, we find the treatise titled in Arabic Kitāb mujarrabāt al-khawāṣṣ (Book of the experience facts) that contains interesting descriptions on the healing attributes, the pharmacological properties and the medical characteristics of diverse plants and animals as well as other rare attributes included in the framework of folk medicine and the quackery, even magic and sorcery. This paper is an approach to this book and contains the English translation of Arabic text according to the manuscript no.520 of the Bodleian Library in Oxford relating to the elecampane (f.41vo-f.42ro), the black caraway (f.52vo-f.53ro) and the ivy (f.81vo.f.82ro).
{"title":"The Medical Qualities of the Elecampane, the Black Caraway and the Ivy According to Abū L-‘Alā’ Zuhr (D.1131)","authors":"L. M. Arvide Cambra","doi":"10.23880/apct-16000201","DOIUrl":"https://doi.org/10.23880/apct-16000201","url":null,"abstract":"Abū l- ‘Alā’ Zuhr (c.1060-1131), known among other names as Abuleli, is one of the most important physicians from AlAndalus who wrote on pharmacology and medicine. He also is the main author in Occident on popular scientific knowledge, as is Al-Majūsī (d.994) in Orient. Among his works, we find the treatise titled in Arabic Kitāb mujarrabāt al-khawāṣṣ (Book of the experience facts) that contains interesting descriptions on the healing attributes, the pharmacological properties and the medical characteristics of diverse plants and animals as well as other rare attributes included in the framework of folk medicine and the quackery, even magic and sorcery. This paper is an approach to this book and contains the English translation of Arabic text according to the manuscript no.520 of the Bodleian Library in Oxford relating to the elecampane (f.41vo-f.42ro), the black caraway (f.52vo-f.53ro) and the ivy (f.81vo.f.82ro).","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116944306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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