Eastern Ukrainian Medical Journal最新文献

{"title":"ASSESSMENT OF DENTAL STUDENTS’ ATTITUDE TO DISTANCE LEARNING: CROSS-SECTIONAL STUDY","authors":"A. Berezhna, Anastasiia O. Liubchenko, Marharyta S. Medvedieva","doi":"10.21272/eumj.2022;10(1):116-123","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(1):116-123","url":null,"abstract":"Introduction. For a long time, the question of the expediency of introducing distance learning in the medical education remained debatable. However, the pandemic of COVID-19 has affected all sides of life. Medical universities were forced to introduce distance learning.\u0000Purpose. To assess dental students’ attitude to distance learning in order to further improve the quality of educational process at the Medical University during the COVID-19 pandemic.\u0000Materials and methods. In October-November, 2021, a cross-sectional epidemiological study on the attitude of students to distance learning and their evaluation of its effectiveness was conducted in Medical University in Kharkiv. Dental students were invited to take part in an online survey created using the Google Forms service. Participation in the survey was anonymous, voluntary and free. All participants were informed about the purpose and objectives of the study. A total of 202 people were surveyed. The average age of the respondents was 19.3 ± 1.8 years.\u0000Methods of descriptive statistics were used for statistical analysis. The significance of difference between the two samples on qualitative characteristics was assessed using Student's t-test. The level of significance was 5%. Statistical data processing was performed using the Microsoft Office 2016 software package.\u0000Results. The majority of respondents (38.6%, n = 78) indicated that distance learning is quite effective, but less effective than traditional university attendance. 20.3% (n = 41) and 7.9% (n = 16) of dental students rated ineffective and inefficient distance learning, respectively. Among those who supported the distance form of practical classes (47.5%, n = 96), the majority of respondents were students of the I–III year (67.7%, n = 65; t-test = 5.25, p < 0.05).\u0000 The analysis of the answers provided by students of the II–V year and interns (in general 170 people) on the practical component of education revealed the following: 53.5% of respondents (n = 91) stated that they gained less practical skills than earlier. Ninety-nine respondents (58.2%) stated that due to the introduction of distance learning they got to lack practical skills, so in the future this could affect them as professionals and the quality of their healthcare service. Almost a third of respondents (34.1%, n = 58) assumed that medical university did not provide proper practical skills, so practical experience would be needed outside the medical university. The vast majority of respondents (71.2%, n = 121) said that there were more opportunities to try dental procedures at work in a dental office than in a phantom class at the medical university.\u0000Conclusions. A significant number of dental students indicated loyalty to distance learning, but they complained about the lack of practical skills. The introduction of mixed and hybrid forms of education that will solve the problem of obtaining practical medical competencies is promising for higher dental education.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122665465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE IMPACT OF THE PANDEMIC CAUSED BY COVID-19 ON THE EPIDEMIOLOGICAL STATE OF HIV INFECTION IN UKRAINE","authors":"M. Chemych, D. S. Sosnovenko, Zoryana V. Kobliuk, N. Skrypka","doi":"10.21272/eumj.2022;10(2):173-181","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(2):173-181","url":null,"abstract":"HIV infection is a human disease with progressive dysfunction of the body's immune system and a long asymptomatic course.\u0000In 2021, there were 42 million HIV-positive people in the world. Today, 341,084 infected people are officially registered in Ukraine. One in one hundred citizens aged 15 to 50 is a carrier of retrovirus. In 2019, the World Health Organization (WHO) confirmed the beginning of a pandemic of a new infectious disease caused by the SARS-CoV-2 virus.\u0000The report of the Global Fund to Fight AIDS and the data of International Charitable Foundation \"Public Health Alliance\" («Альянс громадського здоров’я») state that COVID-19 can seriously disrupt the health care system as well as medical services providing to HIV-infected people in many countries.\u0000Objective. To study the impact of the COVID-19 pandemic on the current HIV epidemic and case registration in Ukraine.\u0000Materials and methods. To complete the tasks, the statistical and epidemiological data of the WHO and the Ministry of Health of Ukraine on the current epidemiological state of HIV infection during 2017–2021 and COVID-19 during 2020–2021 were used.\u0000The results of epidemiological studies were processed with the help of the method of variation statistics using computer programs Microsoft Office Excel 2010, SPSS Statistics and online calculator (http://medstatistic/calculators/calchit.html).\u0000Results and discussion. The epidemiological data provided by the WHO, the Ministry of Health of Ukraine and the International Charitable Foundation \"Public Health Alliance\" on the epidemiological status of HIV infection in 2017–2021 and COVID-19 during 2020–2021 were analyzed.\u0000The COVID-19 pandemic has negatively affected the provision of diagnostic, preventive and curative services to HIV-infected people. This is confirmed by a decrease in the number of rapid tests for retrovirus in 2020 by 4.1 times compared to 2019. The reduction in the number of new cases of HIV, AIDS and mortality from terminal disease in 2020–2021 occurred by an average of 1.5–2.4 times compared to the period before the pandemic caused by coronavirus. These data simultaneously correlated with an increase in COVID-19 cases, the number of rapid tests for coronavirus, and were inversely proportional.\u0000The COVID-19 pandemic will significantly increase the incidence of HIV in Ukraine and raise the number of new AIDS cases and deaths.\u0000Conclusions. The pandemic caused by COVID-19 affected the provision of diagnostic, prophylactic and treatment services to HIV-infected people. There is an inversely proportional trend between the number of confirmed cases of HIV infection and cases of COVID-19. The increase in the incidence of COVID-19 occured in the autumn–winter period, which corresponded to the period of declining levels of HIV diagnosis.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128690376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRELATION BETWEEN THE CHANGES IN HYPERTROPHIC GEOMETRIC MODELS OF THE LEFT VENTRICLE AND CLINICAL, ANTHROPOMETRIC, METABOLIC-HORMONAL PARAMETERS, AND MINERAL METABOLISM INDICATORS","authors":"K. Voroniuk","doi":"10.21272/eumj.2023;11(1):32-40","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(1):32-40","url":null,"abstract":"Objective: to analyze the correlation between the changes in hypertrophic geometric patterns of the left ventricle and the changes in metabolic-hormonal parameters and indicators of mineral metabolism depending on the allelic state of the AGT (rs4762) and GNB3 genes in patients with essential arterial hypertension (EAH).\u0000Material and methods. The case-control study involved 100 patients with EAH stage II, 1–3 degrees of blood pressure (BP) elevation, high and very high cardiovascular risk. Among the patients, there were 21% (21) men and 79% (79) women. The mean age of patients was 59.86 ± 6.22y.o. The control group consisted of 60 apparently healthy individuals, matched on age (49.13 ± 6.28y.o.) and gender distribution (63% women, 37% men). The lipid panel parameters were measured in blood plasma, including TC (total cholesterol), ТG (triglycerides), LDL-C (low-density lipoprotein cholesterol), HDL-C (high-density lipoprotein cholesterol). All subjects were tested for serum levels of fasting glucose, ionized calcium, parathyroid (PTH) hormone, 25-hydroxyvitamin D (Vit D). Left ventricular hypertrophy (LVH) and LVH models were examined by echocardiography. Clinical and anthropometric examination methods were used in the study.\u0000Results. Eccentric left ventricular hypertrophy (ELVH) in patients with EAH was associated with higher blood pressure than concentric left ventricular hypertrophy (CLVH): systolic blood pressure and diastolic blood pressure were higher by 3.29% and 3.95%, respectively (р ≤ 0.05–0.04). ELHV was associated with higher body mass index and waist circumference (WC) in women – by 7.80% and 7.40% (р ≤ 0.05–0.048), respectively. In addition, the ELVH development was characterized by a lower level of ionized Ca2+ in the blood vs. CLVH (by 2.54%, р = 0.021), while the concentration of PTH in a compensatory manner was higher by 23.86% (р = 0.047), which indicated the calcium homeostasis intensity in EAH patients. The lipids, glucose serum concentration and Vit D level were not associated with any hypertrophic model of myocardium.\u0000Conclusions. Lipid profile, blood glucose, and Vit D concentration did not determine the development of any type of the LVH. ELVH was associated with a lower level of Ca2+ and consequently an elevated level of PTH. The formation of ELVH in patients with EAH was accompanied by a higher level of blood pressure and was also associated with higher BMI and WC.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125221124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE COURSE OF CHRONIC KIDNEY DISEASE (CHRONIC PYELONEPHRITIS) IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND OBESITY","authors":"A. Antoniv, Z. Y. Kotsyubiychuk, Volodymyr V. Vivsyanyk, V. Smandych, L. V. Kanyovska, O. Mandryk, O. Liakhovych","doi":"10.21272/eumj.2021;9(3):228-237","DOIUrl":"https://doi.org/10.21272/eumj.2021;9(3):228-237","url":null,"abstract":"The aim of the research: to investigate the features of the comorbid course of chronic kidney disease (CKD) (chronic pyelonephritis), non-alcoholic fatty liver disease and obesity, depending on the stage of CKD.\u0000To achieve this goal, 250 patients with chronic kidney disease (CKD) (chronic bilateral pyelonephritis) stage I–III were examined, of which 160 patients had concomitant NASH and class 1 obesity (1 group) and 90 people had CKD stage I–III without NASH and obesity (group 2). Depending on the stage of CKD, patients of group 1 were divided into 3 subgroups: with CKD stage I – 63 patients, with CKD stage II – 52 patients, with CKD stage III – 45 patients. Patients of group 2 were also divided into 3 subgroups: with CKD stage I – 32 patients, with CKD stage II – 31 patients, with CKD stage III – 27 patients.\u0000The control group included 30 apparently healthy individuals (AHIs). The average age of patients was 49.8 ± 5.8 years. The study did not include patients with CKD stage I–III with nephrotic syndrome and patients with chronic uncomplicated pyelonephritis in the phase of exacerbation.\u0000According to the results of our study, we noted a probable effect of nonalcoholic steatosis and steatohepatitis on the functional state of the kidneys in patients with stage I–III CKD: significant changes in glomerular filtration rate, nitrogen excretory function, increased hypoalbuminemia, increased protein in the urine, erythrocytes, leukocytes, the presence of bacteria, compared with patients with CKD without comorbidity. There was a significant correlation between a decrease in glomerular filtration rate (GFR), an increase in the intensity of oxidative stress, a decrease in blood glutathione, hydrogen sulfide, hyperproduction of homocysteine, cytokeratin-18, connective tissue components (collagen, sialic acids).\u0000In patients with CKD stage I–II without comorbid NASH and obesity, we found a significantly higher renal functional reserve in response to water-electrolyte stimulation, which is sufficient in both groups of patients (increase in GFR by 28–37% vs. 19–31% for comorbidity with NASH). In patients with CKD stage III with nonalcoholic steatohepatitis we found a significantly reduced functional reserve of the kidneys (increase in GFR by 8.9% vs. 17.5% in patients without NASH), and in 4.9% of patients with comorbidity ­– no functional reserve of the kidneys (p > 0.05), indicating irreversible changes in the functional state of the kidneys.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124794323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF NEUROCOGNITIVE IMPAIRMENTS IN PATIENTS WITH MILD COGNITIVE DISORDER OF DIFFERENT ETIOLOGY","authors":"O. Chyniak","doi":"10.21272/eumj.2022;10(4):351-359","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(4):351-359","url":null,"abstract":"Introduction. Mild cognitive disorder (MCD) is a heterogeneous syndrome that involves problems with memory, speech, and thinking that are inconspicuous and do not affect the patient's independence and daily life. The article considers similarities and differences in the neurocognitive profiles of patients with mild cognitive disorders of various etiologies.\u0000Materials and methods. We examined 60 people: 30 subjects aged 50 to 83 years with a mild cognitive disorder of various etiologies and 30 relatively healthy individuals as the control group. All patients underwent a magnetic resonance imaging (MRI) examination of the brain. We used the psychometric method and the following scales: the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment Scale (MoCA), the Frontal Assessment Battery (FAB), the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-cog), the Clinical Dementia Rating (CDR); the results were analyzed using the method of statistical processing.\u0000Results. According to the results of neurocognitive testing, no significant differences were found in the total scores (p = 0.6209), in particular, using the MMSE scale in patients with non-anamnestic (nMCD) and anamnestic (aMCD) мild cognitive disorder and мild cognitive disorder (aMCD). However, patients with nMCD showed significantly lower results with subtests: \"attention and calculation\" (p = 0.0443). According to the MoCA scale, patients with nMCD had a higher score vs. patients with aMCD (p = 0.0457), namely in the \"delayed recall\" subtests (p = 0.0102). Patients with nMCD had significantly lower results with the \"attention and calculation\" subtest (p = 0.0468). No significant differences were found between the groups of patients with MCD according to the results of testing with the FAB scale (p = 0.4778). According to some subtests of the ADAS-cog scale, patients with aMCD showed worse results with the \"word recall\" test (p = 0.0069) and \"word recognition\" (p = 0.0350). In patients with nMCD, lower scores were observed for the subtests \"concentration and distractibility\" (p = 0.0468), \"number cancellation task\" (p = 0.0217), and \"passing the labyrinth\" (p = 0.0015). Patients with aMCD showed significantly lower cognitive abilities than patients with nMCD. Consequently, patients with aMCD may be significantly at high risk of progression to Alzheimer's disease.\u0000Conclusions. After comparing the data of neurocognitive profiles, we established that in patients with anamnestic мild cognitive disorder, the clinical picture presented with a pronounced memory disorder, especially delayed recall, while the patients with non-anamnestic мild cognitive disorder were characterized by regulatory cognitive impairment (attention and calculation, reduced speed of thinking, impaired planning of activities).\u0000The MoCA and ADAS-cog scores had better diagnostic accuracy and specificity for the detection and differential diagnosis of mild cognitive disorders than the MMSE scale.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128348643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENDOGENOUS INTOXICATION SYNDROME ACTIVITY IN BILIARY AUTONOMIC VISCERO-VISCERAL CARDIONEUROPATHY","authors":"L. Strilchuk, M. Kondratyuk","doi":"10.21272/eumj.2021;9(2):151-156","DOIUrl":"https://doi.org/10.21272/eumj.2021;9(2):151-156","url":null,"abstract":"Toxic excess of biologically active substances named middle molecules (MM), which include byproducts of normal and altered metabolism, products of inflammation and oxidation, bacterial remnants, antibodies and immunoactive substances, plays an important role in pathogenesis of gallbladder diseases and biliary autonomous viscero-visceral cardioneuropathy (BAVVCNP). In order to assess activity of the endogenous intoxication syndrome secondary to BAVVCNP, we examined 20 patients with coronary heart disease to determine the levels of MM in the blood (total and at 238, 254, 266, and 280 nm waves); the levels of MM in urine (at 238, 254, 266, 282, 288, and 310 nm waves) with calculation of aromaticity index (MM 238/280), peptide-nucleotide index (MM 238/266), distribution index (MM 280/254), and L-arginine, and nitrites of the urine. The results were statistically processed.\u0000It was revealed that in case of BAVVCNP the severity of the endogenous intoxication syndrome was higher for all specific parameters of endotoxicosis, and especially for the total level of MM in blood (0.77 ± 0.13 units vs. 0.46 ± 0.13 units, p = 0.08), the MM level at 238 nm wave (1.53 ± 0.55 vs. 0.49 ± 0.06, p = 0.08) and hydrophilic MM level in the urine at 288 nm long waves (0.72 ± 0.12 vs. 0.40 ± 0.11, p = 0.05) and 310 nm (0.27 ± 0.08 vs. 0.10 ± 0.03, p <0.05). According to the literature, this may indicate an increase in levels of cholecystokinin, leptin, endothelin, proinflammatory interleukins and tumor necrosis factor α. According to the correlation analysis, activation of endogenous intoxication syndrome was associated with lipid distress syndrome, increased leptin content and accelerated renal filtration.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123111965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ONCOLOGICAL SERVICE PROVISION WITHIN THE MEDICAL CARE GUARANTEE PACKAGE OF THE NATIONAL HEALTH SERVICE \"TREATMENT AND FOLLOW-UP OF ADULTS AND CHILDREN WITH HEMATOLOGICAL AND ONCOHEMATOLOGICAL DISEASES IN OUTPATIENT AND IN-PATIENT SETTINGS\"","authors":"Nataliya Husak, V. Zub, A. Kotuza","doi":"10.21272/eumj.2023;11(2):184-193","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(2):184-193","url":null,"abstract":"Introduction. The approaches to the criteria for assigning a treated case/interaction to oncology packages and the principles of their payment introduced by the National Health Service need to be improved in order to prevent the introduction of inadequate tariffs, in particular, failure to provide services in the amount specified in the tariff or, on the contrary, double/triple funding, which can lead to a significant increase in the costs of financing oncology medical services.\u0000The aim of the study is the identification of the main defects and gaps in the existing rules of the grouper regarding the assignment of a treated case/interaction to the oncology package \"Treatment and follow‑up of adults and children with hematological and oncohematological diseases in outpatient and inpatient settings\" and, on this basis, developing suggestions for improving services in this direction.\u0000Materials and Methods. A descriptive-analytical study of the analysis of medical services provided in the oncology package 38 \"Treatment and follow-up of adults and children with hematological and oncohematological diseases in outpatient and inpatient settings\" for the first 8 months of 2022 was performed according to the data of the National Health Service of Ukraine and the normative legal acts that regulate the issue of implementing the Medical Guarantees Program.\u0000Results. The study assessed the correctness of the criteria for the entry of Electronic Medical Records into package 38 compared to the Australian coding standards and analyzed the consistency of payment according to the rate for the provided medical services to patients with oncological and oncohematological diseases within the limits of all interactions of package 38.\u0000Certain inconsistencies in the selection of diagnoses for inclusion in the list of reasons for providing medical services and the vagueness of the criteria for including a case in the package were revealed, when a specific diagnosis is a criterion for inclusion in both the 38th package and the corresponding DRG, but with different funding. It was established that 1/5 of all children within the framework of this package sought medical help in an outpatient setting only once or twice, and the list of interventions does not correspond to the package rate; among adults, there was a significant number of patients who sought medical care 1 or 2 times in an outpatient setting, and paid for these cases at the full rate.\u0000The findings indicate an urgent need for two-stage medical monitoring of all interactions established for oncological diagnoses within the framework of the therapeutic package. The first automatic monitoring should be carried out according to certain indicators with the formation of \"a red list of interactions\", and then doctors check these interactions, even in manual mode.\u0000Conclusions. On the basis of the results, recommendations were developed regarding changes to the Medical Guarantee Program in oncology, namely to the interaction","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"257 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115009644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL PATHOGENETIC SUBSTANTIATION OF THE REGENERATIVE TREATMENT OF PARTURIENTS WHO SUFFERED FROM OBSTETRICAL HAEMORRHAGES","authors":"S. Herasymenko, I. Nikitina, S. Smiian","doi":"10.21272/eumj.2023;11(2):136-142","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(2):136-142","url":null,"abstract":"The publication is devoted to an urgent problem of modern obstetrics – the study of pathophysiological changes in the organism of parturients after obstetrical haemorrhages, improvement of restorative treatment, as well as reduction of complications in the puerperium and prevention of their occurrence.\u0000The aim of the study: to increase the effectiveness of restorative treatment of women in labor who suffered obstetric bleeding by studying the features of the clinical course, mechanisms of pathogenetic disorders, and their correction using ozone therapy.\u0000Materials and methods. A comprehensive clinical and laboratory examination of 150 women in labor was carried out, including 120 women (the main group) who suffered bleeding during childbirth and the early postpartum period. The control group consisted of 30 women with the physiological course of labor, childbirth and the early postpartum period. The state of lipid peroxidation (LPO) in parturient women was evaluated by the content of primary lipid products in the blood plasma – diene conjugates (DK) according to the method of B.V. Gavrilov (1983) and secondary molecular products – malondialdehyde (MDA) using the reaction with 2 thiobarbituric acid. The activity of the enzymatic link of the antioxidant system (AOS) was determined by the content of catalase in peripheral blood erythrocytes using the substrate hydrogen peroxide and glutathione peroxidase (GPO) using the P phenylenediamine substrate. The Spielberg–Hanin scale of state and trait anxiety was used to study the state of the psycho-emotional sphere in parturient women. Morphological examination of preparations of placentas and surgically removed uteri was carried out with staining of sections with hematoxylin and eosin, picrofuchsin according to Van Gieson.\u0000Results. Basic etiopathogenetic factors of the development of obstetric haemorrhages were examined, changes in the psychoemotional status of the patients were detected, haematological and metabolic indices, parameters of oxidation-antioxidation homeostasis and endogenic intoxication were studied, as well as morphofunctional disorders in placentas and uteruses. The efficacy of the restorative treatment of the parturients, who had moderate and massive haemorrhages during delivery, with the use of medical ozone in combined treatment versus traditional methods of treatment was studied.\u0000Conclusion. From the first day of the puerperium, free-radical lipid peroxidation increases, the activity of the enzymatic and non-enzymatic links of the antioxidant system increases, endogenous intoxication increases, and lactate and pyruvate levels increase. In the placentas of women in labor who suffered bleeding during labor, there is a violation of the synthesis of type IV collagen in the basal membranes of vessels and the phenomenon of endothelial dysfunction in the form of increased expression of endothelin by the endotheliocytes of the vessels of the decidual membrane (53.8 ± 2.9 µa) and the villous c","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134018594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL CASE: RARE COURSE OF JUVENILE SCLERODERMA IN RESIDENTS OF DONETSK REGION","authors":"A. A. Koniushevska, Тatiana A. Parkhomenko, Natalia V. Vaizer, O. V. Tymoshyna, M. V. Kuzevanova","doi":"10.21272/eumj.2022;10(1):17-24","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(1):17-24","url":null,"abstract":"The article presents a clinical case of a rare onset and a special clinical course of juvenile scleroderma. A clinical case of a child who was born and lives in the ecologically unfavorable industrial Donetsk region is described.\u0000The literature review of influence of unfavorable environment on morbidity and features of autoimmune pathology course in patients of Donetsk region is offered. In particular, the literature indicates that negative environmental factors lead to an increase in the progression of systemic scleroderma; over the past 20 years, there has been a tendency to increased mortality of children suffering from it, which is associated with deteriorating environmental conditions in industrial regions. The growing incidence and prevalence of scleroderma, the variety of clinical manifestations, and difficulties in early diagnosis of the disease make it important to study the options for the course of this pathology in children and adolescents in the early stages of the disease.\u0000A feature of this clinical case was the onset of juvenile scleroderma with severe convulsive syndrome at the age of 8 years, which required Finlepsin at a dose of 200 mg daily. Further course was also uncharacteristic: within 2 years, there was a linear indentation in the forehead on the right side; the patient was diagnosed with linear \"saber-shaped\" limited scleroderma, Parry–Romberg facial hemiatrophy syndrome, and further developed manifestations of systemic involvement, lesions of internal organs: pneumofibrosis and scleroderma esophagitis. The management and observation of the patient are presented here. It was emphasized that early aggressive intervention led to the prevention of severe organ pathology and death.\u0000The described clinical case expands the knowledge of physicians on the clinical polymorphism of the onset and course of the disease, which allows faster and more accurate identification of the disease, timely and adequate therapy, and will lead to earlier stabilization and remission of the disease.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130159785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE RELATIONSHIP BETWEEN DECREASED COGNITIVE FUNCTIONS AND THE LEVEL OF PROINFLAMMATORY CYTOKINES IN PATIENTS WITH ALZHEIMER’S DISEASE, VASCULAR DEMENTIA, AND MILD COGNITIVE DISORDER","authors":"O. Chyniak, O. Dubenko, Olexander Potapov","doi":"10.21272/eumj.2021;9(3):247-255","DOIUrl":"https://doi.org/10.21272/eumj.2021;9(3):247-255","url":null,"abstract":"Alzheimer's disease (AD) is a degenerative disease that leads to dementia symptoms [1, 2]. Histopathological signs of AD are amyloid plaques in the brain, mainly consisting of fibrillary forms of amyloid β-peptide-40 (Aβ-40) and amyloid β-peptide-42 (Aβ-42). Neutrophils are the main targets for IL-17 in the central nervous system (CNS) that promote inflammation and damage to CNS tissues, and may play an important role in the development of AD pathology. Interleukin 23 (IL‑23) synergizes with IL-6, IL-1 and is involved in the differentiation of Th17 cells in a pro-inflammatory context.\u0000The aim of the study was to analyze the relationship between interleukin levels of IL-17, IL-23 and neurocognitive scales in patients with AD, vascular dementia (VD) and mild cognitive disorder (MCD).\u0000The study involved 89 patients, of which 59 patients had cognitive impairment (32 men and 27 women, mean age 66.8±8.4 years); among them, 29 had major neurocognitive impairment (NCD), including 15 patients with AD, 14 – with VD, 30 patients – with MCD and 30 people in the control group had no cognitive deficit.\u0000All patients were tested with comprehensive neuropsychological examination using the following tests and scales: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), Alzheimer Disease Assessment Scale-cognitive (ADAScog).\u0000Serum levels of cytokines of IL-17 and IL-23 were assayed using sandwich ELISA on «Chem Well 2900» immunoanalyzer (Awareness Technology, USA). Test systems using Bender Medsystems, Australia (IL-17 and IL-23) were used in accordance with the manufactures instructions.\u0000Levels of detectable interleukins (IL-17 and IL-23) were significantly higher in patients with AD vs. patients with VD and MCD. The correlations between the two cytokines and the MMSE scales, MoCA, ADAS-cog and FAB were examined. Our results showed a significant positive correlation between the serum concentration of IL-23 and neurocognitive scales in all patients with AD. The most relevant correlations in the AD group were linked with the scales: ADAS-cog (r = 0.760; р = 0.001), namely with the sections «tasks for repeating words» (r = 0.775; p ˂ 0.001), «constructive praxis» (r = 0.651; p = 0.010), «orientation» (r = 0.684; p = 0.01), as well as «word recognition tasks» (r = 0.616; p = 0.020); and with MoCA scale (r = −0.592; p = 0.020), namely with the section «delayed recall» (r = −0.641; p = 0.010). A significant positive correlation was established between IL-23 and individual sections of the ADAS-cog scale in patients with MCD (r = 0.423; p = 0.020), namely with «word recognition tasks» (r = 0.466; p = 0.030), «understanding» (r = 0.306; p = 0.059) as well as «strike out numbers» (r = 0.301; p = 0.061). A weak positive correlation was found between the serum concentration of IL-23 and ADAS-cog scores in patients with VD (r = 0.497; p = 0.045). Moderate positive correlation was observed for IL-23 with «concentration and","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114854928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}