Pub Date : 1900-01-01DOI: 10.21272/eumj.2022;10(1):25-32
N. Kretsu, O. Koloskova, Oleksiy M. Kozma
Neonatal sepsis (NS) is the leading cause of morbidity and mortality in intensive care units. The issue of early diagnosis of a purulent-septic process in newborns using modern research methods that can be used as screening methods for verifying the diagnosis remains relevant. Objective. To conduct a comparative analysis of clinical and laboratory features of the course of early and late neonatal sepsis to optimize the early diagnosis of infectious-inflammatory process at the stage of obstetric institutions. Material and methods. To achieve this goal, retrospectively 26 medical records of newborns at the stage of obstetric institutions were analyzed, which were later transferred for treatment to the Regional Municipal Non-Profit Enterprise "Chernivtsi Regional Children's Clinical Hospital" in Chernivtsi with manifestations of generalized infectious-inflammatory process. The first group consisted of 14 (53.8%) newborns diagnosed with early neonatal sepsis; the second group included 12 (46.2%) newborns that were diagnosed with late neonatal sepsis (p > 0.05). Research results. Peculiarities of the clinical manifestation of the infectious-inflammatory process should be recognized as a combination of several locus of infection, which occurred in group I in 57.1% of cases, in group II – in 16.6% of cases (p < 0.05). Muffled heart sounds at the initial examination and a tendency to thermolability were more common in newborns with early NS: OR – 6.1 (95% CI 2.71–13.92), RR – 1.97 (95% CI 0.97–3.97), AR – 0.39 and OR – 3.6 (95% CI 2.01–6.46), RR – 1.89 (95% CI 1.38–2.58), AR – 0.31. Conclusion. The analysis revealed that in early neonatal sepsis the risk of detecting muffled heart sounds during auscultation (odds ratio – 6.1), unstable body temperature (odds ratio – 3.6) and absolute leukocyte count > 20.0×109/L is significantly higher (odds ratio – 2.79).
新生儿败血症(NS)是重症监护病房发病率和死亡率的主要原因。使用现代研究方法早期诊断新生儿脓毒性过程，可作为验证诊断的筛查方法，这一问题仍然具有相关性。对新生儿早期和晚期脓毒症的临床和实验室特征进行比较分析，以优化产科机构阶段感染-炎症过程的早期诊断。材料和方法。为了实现这一目标，回顾性分析了产科机构阶段26例新生儿的医疗记录，这些新生儿后来被转移到切尔诺夫茨的区域市政非营利企业“切尔诺夫茨地区儿童临床医院”进行治疗，表现为全身感染-炎症过程。第一组14例(53.8%)新生儿诊断为早期新生儿败血症;第二组有12例(46.2%)新生儿被诊断为晚期新生儿脓毒症(p < 0.05)。研究的结果。感染-炎症过程临床表现的特殊性应被认为是多个感染位点的结合，其中I组为57.1%，II组为16.6% (p < 0.05)。初诊心音不清和发热倾向在早期NS新生儿中更为常见:OR - 6.1 (95% CI 2.71 ~ 13.92)， RR - 1.97 (95% CI 0.97 ~ 3.97)， AR - 0.39和OR - 3.6 (95% CI 2.01 ~ 6.46)， RR - 1.89 (95% CI 1.38 ~ 2.58)， AR - 0.31。分析显示，在新生儿早期败血症中，听诊时发现心音不清(优势比- 6.1)、体温不稳定(优势比- 3.6)和绝对白细胞计数> 20.0×109/L的风险明显更高(优势比- 2.79)。
{"title":"CLINICAL AND LABORATORY FEATURES OF EARLY AND LATE NEONATAL SEPSIS COURSE AT THE STAGE OF OBSTETRIC INSTITUTIONS","authors":"N. Kretsu, O. Koloskova, Oleksiy M. Kozma","doi":"10.21272/eumj.2022;10(1):25-32","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(1):25-32","url":null,"abstract":"Neonatal sepsis (NS) is the leading cause of morbidity and mortality in intensive care units. The issue of early diagnosis of a purulent-septic process in newborns using modern research methods that can be used as screening methods for verifying the diagnosis remains relevant.\u0000Objective. To conduct a comparative analysis of clinical and laboratory features of the course of early and late neonatal sepsis to optimize the early diagnosis of infectious-inflammatory process at the stage of obstetric institutions.\u0000Material and methods. To achieve this goal, retrospectively 26 medical records of newborns at the stage of obstetric institutions were analyzed, which were later transferred for treatment to the Regional Municipal Non-Profit Enterprise \"Chernivtsi Regional Children's Clinical Hospital\" in Chernivtsi with manifestations of generalized infectious-inflammatory process. The first group consisted of 14 (53.8%) newborns diagnosed with early neonatal sepsis; the second group included 12 (46.2%) newborns that were diagnosed with late neonatal sepsis (p > 0.05).\u0000Research results. Peculiarities of the clinical manifestation of the infectious-inflammatory process should be recognized as a combination of several locus of infection, which occurred in group I in 57.1% of cases, in group II – in 16.6% of cases (p < 0.05). Muffled heart sounds at the initial examination and a tendency to thermolability were more common in newborns with early NS: OR – 6.1 (95% CI 2.71–13.92), RR – 1.97 (95% CI 0.97–3.97), AR – 0.39 and OR – 3.6 (95% CI 2.01–6.46), RR – 1.89 (95% CI 1.38–2.58), AR – 0.31.\u0000Conclusion. The analysis revealed that in early neonatal sepsis the risk of detecting muffled heart sounds during auscultation (odds ratio – 6.1), unstable body temperature (odds ratio – 3.6) and absolute leukocyte count > 20.0×109/L is significantly higher (odds ratio – 2.79).","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"209 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133482286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21272/eumj.2021;9(3):268-274
Julia A. Zaikina
The combination of bronchial asthma and obesity leads to increased severity of bronchial asthma course and poorer control level, the development of resistance to basic therapy, and increased frequency of hospitalizations. Modern approaches to the treatment of bronchial asthma and obesity suggest that more attention should be paid to comprehensive rehabilitation programs using methods aimed at all pathogenesis stages of this combination of diseases. Objective: to analyze changes in clinical and functional indicators over time in overweight patients with bronchial asthma receiving standard therapy vs. standard therapy with a complex of rehabilitation measures The study involved 102 overweight patients (body mass index (BMI) ≤ 39.9 kg/height, m2) with persistent asthma of moderate severity aged 35–60 years. The patients were divided into 2 groups. Group I included 72 patients receiving standard pharmacologic therapy (budesonide 160 μg and formoterol 4.5 μg) along with a diet close to the Mediterranean diet, as well as a complex of rehabilitation measures, which included Buteyko breathing technique plus respiratory gymnastics and dosed walking. Group II (30 patients) received only standard pharmacologic therapy along with a diet close to the Mediterranean diet. The duration of the therapy was 6 months. All patients underwent general clinical studies, spirometry, the 6-minute walk test (6MWT) with dyspnea assessment according to the Borg Dyspnoea Scale, surveys using the Asthma Control Questionnaire-5, St George's Respiratory Questionnaire (SGRQ), Beck Depression Inventory, and Spielberger–Khanin Anxiety Inventory. It was found that the patients receiving treatment along with physical rehabilitation measures presented with more pronounced positive changes, so the indices of FVC and 6MWT medians in Group I were 6 times and 2.4 times higher, respectively. The changes in ACQ5, SGRQ, BDI, and SAI-t score medians in Group I were also more prominent and exceeded the values in Group II by 1.8 times, 4.4 times, 2.5 times, and 3.5 times, respectively. Inclusion of physical rehabilitation measures, i.e. Buteyko breathing technique, respiratory gymnastics, and dosed walking, contributes to a significant increase in FEV1 and statistically significant improvement in quality of life and psychological status after 6 months of therapy.
{"title":"CLINICAL AND FUNCTIONAL INDICATORS OVER TIME IN OVERWEIGHT PATIENTS WITH BRONCHIAL ASTHMA RECEIVING STANDARD THERAPY VS. STANDARD THERAPY WITH A COMPLEX OF REHABILITATION MEASURES","authors":"Julia A. Zaikina","doi":"10.21272/eumj.2021;9(3):268-274","DOIUrl":"https://doi.org/10.21272/eumj.2021;9(3):268-274","url":null,"abstract":"The combination of bronchial asthma and obesity leads to increased severity of bronchial asthma course and poorer control level, the development of resistance to basic therapy, and increased frequency of hospitalizations. Modern approaches to the treatment of bronchial asthma and obesity suggest that more attention should be paid to comprehensive rehabilitation programs using methods aimed at all pathogenesis stages of this combination of diseases.\u0000Objective: to analyze changes in clinical and functional indicators over time in overweight patients with bronchial asthma receiving standard therapy vs. standard therapy with a complex of rehabilitation measures\u0000The study involved 102 overweight patients (body mass index (BMI) ≤ 39.9 kg/height, m2) with persistent asthma of moderate severity aged 35–60 years. The patients were divided into 2 groups. Group I included 72 patients receiving standard pharmacologic therapy (budesonide 160 μg and formoterol 4.5 μg) along with a diet close to the Mediterranean diet, as well as a complex of rehabilitation measures, which included Buteyko breathing technique plus respiratory gymnastics and dosed walking. Group II (30 patients) received only standard pharmacologic therapy along with a diet close to the Mediterranean diet. The duration of the therapy was 6 months. All patients underwent general clinical studies, spirometry, the 6-minute walk test (6MWT) with dyspnea assessment according to the Borg Dyspnoea Scale, surveys using the Asthma Control Questionnaire-5, St George's Respiratory Questionnaire (SGRQ), Beck Depression Inventory, and Spielberger–Khanin Anxiety Inventory.\u0000It was found that the patients receiving treatment along with physical rehabilitation measures presented with more pronounced positive changes, so the indices of FVC and 6MWT medians in Group I were 6 times and 2.4 times higher, respectively. The changes in ACQ5, SGRQ, BDI, and SAI-t score medians in Group I were also more prominent and exceeded the values in Group II by 1.8 times, 4.4 times, 2.5 times, and 3.5 times, respectively.\u0000Inclusion of physical rehabilitation measures, i.e. Buteyko breathing technique, respiratory gymnastics, and dosed walking, contributes to a significant increase in FEV1 and statistically significant improvement in quality of life and psychological status after 6 months of therapy.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115935164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21272/eumj.2021;9(4):318-324
O. Potapov, Oleksiy Kmyta, O. Tsyndrenko, Maryna V. Pavlova, Dmytro A. Zaporozhets
Introduction. Degenerative disc disease is one of the most common diseases of the musculoskeletal system, characterized by dystrophic changes in the intervertebral disc and vertebral bodies adjacent to it. The main symptoms of this disease are pain and sensory and motor disorders, which, according to various authors, occur in 50–80% of adults. The main objective of the study was to find and implement the optimal set of treatment measures for degenerative disc disease depending on the age of a patient. Materials and Methods. The medical records of inpatients who were treated in the Neurosurgical Department of the Sumy Regional Clinical Hospital in 2019–2020 were analyzed. The course of treatment of 93 patients (61 men and 32 women) was studied. The patients were divided into groups according to their age: young age (under 25) – 13 men and 8 women; middle age (under 60) – 24 men and 19 women; and elderly age (over 60 years) – 18 men and 11 women. The combined use of pathogenetically justified physiotherapeutic measures in the treatment complex is gaining more and more interest. Their distinctive features are physiologic nature, absence of allergic manifestations, the ability to influence most of the pathogenesis of the disease, and the organic combination with other therapeutic factors. Unfortunately, there is an increase in the incidence of temporary incapacitation and progressive course, which often leads to disability and significant financial costs associated with expensive modern methods of diagnosis, treatment, and further provision of employment to patients. The results of our study show that complex treatment including pathogenetic drug therapy, complex paravertebral block, therapeutic physical exercise, and physiotherapy treatment methods provides adequate recovery of spinal function regardless of dystrophic and degenerative changes severity and patient's age. Treatment of degenerative disc disease should be comprehensive and directed at the various symptoms and links of the pathological process.
{"title":"COMPREHENSIVE TREATMENT OF DISCOPATHIES OF THE LUMBAR SPINE","authors":"O. Potapov, Oleksiy Kmyta, O. Tsyndrenko, Maryna V. Pavlova, Dmytro A. Zaporozhets","doi":"10.21272/eumj.2021;9(4):318-324","DOIUrl":"https://doi.org/10.21272/eumj.2021;9(4):318-324","url":null,"abstract":"Introduction. Degenerative disc disease is one of the most common diseases of the musculoskeletal system, characterized by dystrophic changes in the intervertebral disc and vertebral bodies adjacent to it. The main symptoms of this disease are pain and sensory and motor disorders, which, according to various authors, occur in 50–80% of adults.\u0000The main objective of the study was to find and implement the optimal set of treatment measures for degenerative disc disease depending on the age of a patient.\u0000Materials and Methods. The medical records of inpatients who were treated in the Neurosurgical Department of the Sumy Regional Clinical Hospital in 2019–2020 were analyzed. The course of treatment of 93 patients (61 men and 32 women) was studied. The patients were divided into groups according to their age: young age (under 25) – 13 men and 8 women; middle age (under 60) – 24 men and 19 women; and elderly age (over 60 years) – 18 men and 11 women.\u0000The combined use of pathogenetically justified physiotherapeutic measures in the treatment complex is gaining more and more interest. Their distinctive features are physiologic nature, absence of allergic manifestations, the ability to influence most of the pathogenesis of the disease, and the organic combination with other therapeutic factors. Unfortunately, there is an increase in the incidence of temporary incapacitation and progressive course, which often leads to disability and significant financial costs associated with expensive modern methods of diagnosis, treatment, and further provision of employment to patients.\u0000The results of our study show that complex treatment including pathogenetic drug therapy, complex paravertebral block, therapeutic physical exercise, and physiotherapy treatment methods provides adequate recovery of spinal function regardless of dystrophic and degenerative changes severity and patient's age.\u0000Treatment of degenerative disc disease should be comprehensive and directed at the various symptoms and links of the pathological process.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116285898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21272/eumj.2023;11(2):103-112
Julia Rebriy, L. Sukhodub, V. Kasianchuk
Introduction. This mini-review examines the mechanisms of damage to bacterial biofilms (BB) by particles of metals (Au, Ag, Fe, Cu, Zn, Mg) and their oxides (AuО, SiO, Fe2О3, Ag2O, CuO, TiO2, ZnO, and MgO). Emphasis is placed on the mechanism which includes the formation of reactive oxygen species that affect the redox state of the bacterial cell and, as a result, its death. The mechanism of the antibacterial action of particles, ZnO, as well as their effect on the porosity and degree of swelling of the apatite-biopolymer composite, were considered in more detail. Due to the emergence of antibiotic resistance of bacterial biofilms, it has become increasingly difficult to treat them effectively. Materials and Methods. An analytical review of scientific publications was conducted using official databases. The scientific research method was employed to achieve the objective. Results. The study showed that nanoparticles of metal oxides could have a detrimental effect on bacterial biofilms using various mechanisms of antibacterial action, including oxidative stress, biofilm inhibition, inhibition of protein synthesis and DNA damage, damage to metabolic pathways, penetration through the cell membrane, and interaction with the cell wall and membrane. Conclusion. To further utilize nanoparticles of metal oxides (copper, gold, silver, titanium, and iron), the primary mechanisms of their influence on the structure of bacterial biofilms (BBs) were studied based on papers published in the world’s scientific literature. NPs have different classifications and differ in chemical composition and physical parameters, such as nanosize and surface-to-volume ratio.
{"title":"CHARACTERISTICS OF NANOMETRIC PARTICLES OF METAL OXIDES","authors":"Julia Rebriy, L. Sukhodub, V. Kasianchuk","doi":"10.21272/eumj.2023;11(2):103-112","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(2):103-112","url":null,"abstract":"Introduction. This mini-review examines the mechanisms of damage to bacterial biofilms (BB) by particles of metals (Au, Ag, Fe, Cu, Zn, Mg) and their oxides (AuО, SiO, Fe2О3, Ag2O, CuO, TiO2, ZnO, and MgO). Emphasis is placed on the mechanism which includes the formation of reactive oxygen species that affect the redox state of the bacterial cell and, as a result, its death. The mechanism of the antibacterial action of particles, ZnO, as well as their effect on the porosity and degree of swelling of the apatite-biopolymer composite, were considered in more detail. Due to the emergence of antibiotic resistance of bacterial biofilms, it has become increasingly difficult to treat them effectively.\u0000Materials and Methods. An analytical review of scientific publications was conducted using official databases. The scientific research method was employed to achieve the objective.\u0000Results. The study showed that nanoparticles of metal oxides could have a detrimental effect on bacterial biofilms using various mechanisms of antibacterial action, including oxidative stress, biofilm inhibition, inhibition of protein synthesis and DNA damage, damage to metabolic pathways, penetration through the cell membrane, and interaction with the cell wall and membrane.\u0000Conclusion. To further utilize nanoparticles of metal oxides (copper, gold, silver, titanium, and iron), the primary mechanisms of their influence on the structure of bacterial biofilms (BBs) were studied based on papers published in the world’s scientific literature. NPs have different classifications and differ in chemical composition and physical parameters, such as nanosize and surface-to-volume ratio.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116348998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21272/eumj.2022;10(1):57-63
Ben Otmen Mabrouk, Y. Nechytailo, Tetiana M. Mikheeva, D. Nechytailo
Among the diseases of the lower part of respiratory system in children, acute bronchitis dominates, often with obstructive syndrome and ventilation disorders. To assess the severity of the obstructive syndrome spirometry is used, which is the "gold standard" for this purpose. It combines two groups of tests: spirography – graphical recording of changes in lung volumes during respiratory movements and pneumotachography – graphical recording of the air flow velocity during tidal and forced breathing. Among modern methods, non-invasive determination of blood oxygen saturation with pulse oximetry is becoming increasingly popular. The combined use of spirometry and pulse oximetry makes it possible to determine accurately the state and reserves of the cardiorespiratory system in a wide range of pathological changes. Objective. To learn the features of ventilation function and gas exchange in children with acute bronchitis. Materials and methods. The paper analyzes the results of a survey of 59 children with acute bronchitis. Patients underwent a clinical examination, spirometry, pulse oximetry; breath-hold tests were performed. The results of spirometry and pulse oximetry were compared with the data of clinically healthy children (23 children). Results. In children, the severity of bronchitis was moderate according to the BSS-7.79 ± 0.19 points, 30 patients had symptoms of obstructive syndrome. Spirometry recorded a decrease in forced respiratory volumes, peak forced expiratory flow and inspiratory flow. Pulse oximetry showed a relatively lower level of oxygen saturation in patients, which worsened during breath-hold tests. The obtained results indicate impaired ventilation and gas exchange in children with bronchitis, even with a mild course of the disease, especially in the presence of obstructive phenomena. Compensatory mechanisms for maintaining blood saturation based mainly on an increase in systemic blood flow due to an increase in heart rate. Conclusions. In acute bronchitis in children, ventilation and gas exchange rates decrease, even in those patients with a mild course. Compensatory mechanisms for maintaining blood saturation are based mainly on increased systemic blood flow due to increased heart rate.
{"title":"CHANGES IN VENTILATION FUNCTION AND RESERVES OF GAS EXCHANGE IN CHILDREN WITH ACUTE BRONCHITIS","authors":"Ben Otmen Mabrouk, Y. Nechytailo, Tetiana M. Mikheeva, D. Nechytailo","doi":"10.21272/eumj.2022;10(1):57-63","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(1):57-63","url":null,"abstract":"Among the diseases of the lower part of respiratory system in children, acute bronchitis dominates, often with obstructive syndrome and ventilation disorders. To assess the severity of the obstructive syndrome spirometry is used, which is the \"gold standard\" for this purpose. It combines two groups of tests: spirography – graphical recording of changes in lung volumes during respiratory movements and pneumotachography – graphical recording of the air flow velocity during tidal and forced breathing. Among modern methods, non-invasive determination of blood oxygen saturation with pulse oximetry is becoming increasingly popular. The combined use of spirometry and pulse oximetry makes it possible to determine accurately the state and reserves of the cardiorespiratory system in a wide range of pathological changes.\u0000Objective. To learn the features of ventilation function and gas exchange in children with acute bronchitis.\u0000Materials and methods. The paper analyzes the results of a survey of 59 children with acute bronchitis. Patients underwent a clinical examination, spirometry, pulse oximetry; breath-hold tests were performed. The results of spirometry and pulse oximetry were compared with the data of clinically healthy children (23 children).\u0000Results. In children, the severity of bronchitis was moderate according to the BSS-7.79 ± 0.19 points, 30 patients had symptoms of obstructive syndrome. Spirometry recorded a decrease in forced respiratory volumes, peak forced expiratory flow and inspiratory flow. Pulse oximetry showed a relatively lower level of oxygen saturation in patients, which worsened during breath-hold tests. The obtained results indicate impaired ventilation and gas exchange in children with bronchitis, even with a mild course of the disease, especially in the presence of obstructive phenomena. Compensatory mechanisms for maintaining blood saturation based mainly on an increase in systemic blood flow due to an increase in heart rate.\u0000Conclusions. In acute bronchitis in children, ventilation and gas exchange rates decrease, even in those patients with a mild course. Compensatory mechanisms for maintaining blood saturation are based mainly on increased systemic blood flow due to increased heart rate.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"778 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116414429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21272/eumj.2021;9(3):238-246
Valentyna P. Polanska, V. I. Fedorchenko, S. Zachepilo, N. Bobrova
Candida albicans occupies a dominant position in the list of causative agents of candidal lesions of the ear. The development of new antifungal agents, an alternative source of which can be herbal essential oils and their components, remains a priority. One such agent with antiseptic, anti-inflammatory, and analgesic action is eugenol which is a phenol substance. Therefore, this article was aimed to study the effectiveness of the antifungal action of eugenol emulsified in Polysorbate-80 against clinical strains of C. albicans isolated from patients with external otomycosis. The study was performed using 6 clinical strains of C. albicans isolated from the ear canal of patients with otitis externa. The diagnosis of fungal disease was established based on the results of clinical and laboratory (microscopical and mycological) studies of pathological material. Analysis of mycological research showed that mainly representatives of the genus Aspergillus and Penicillium were revealed and only in 7% there were Candida genus fungi. C. albicans remained the dominant species of clinical significance. The results of our studies showed a high level of antifungal activity of eugenol on all clinical strains of C. albicans, including a remarkable inhibitory and fungicidal effect. At postmycostatic concentrations, the eugenol caused partial inhibition of reproduction of the clinical strains of fungi, which was replaced by a subsequent increased cell reproduction rate. So, the investigation has shown that C. albicans is the dominant species among fungi of the Candida genus in the structure of the microbial profile of otomycoses. The eugenol, emulsified in Polysorbate-80, has a high antifungal effect against clinical strains of C. albicans. At postmycostatic concentrations, the eugenol caused partial inhibition of reproduction of the clinical strains of fungi, which was replaced by a subsequent increase cell reproduction rate.
{"title":"EFFECT OF EUGENOL EMULSION IN POLYSORBATE-80 ON CLINICAL STRAINS OF CANDIDA ALBICANS","authors":"Valentyna P. Polanska, V. I. Fedorchenko, S. Zachepilo, N. Bobrova","doi":"10.21272/eumj.2021;9(3):238-246","DOIUrl":"https://doi.org/10.21272/eumj.2021;9(3):238-246","url":null,"abstract":"Candida albicans occupies a dominant position in the list of causative agents of candidal lesions of the ear. The development of new antifungal agents, an alternative source of which can be herbal essential oils and their components, remains a priority. One such agent with antiseptic, anti-inflammatory, and analgesic action is eugenol which is a phenol substance. Therefore, this article was aimed to study the effectiveness of the antifungal action of eugenol emulsified in Polysorbate-80 against clinical strains of C. albicans isolated from patients with external otomycosis.\u0000The study was performed using 6 clinical strains of C. albicans isolated from the ear canal of patients with otitis externa. The diagnosis of fungal disease was established based on the results of clinical and laboratory (microscopical and mycological) studies of pathological material.\u0000Analysis of mycological research showed that mainly representatives of the genus Aspergillus and Penicillium were revealed and only in 7% there were Candida genus fungi. C. albicans remained the dominant species of clinical significance. The results of our studies showed a high level of antifungal activity of eugenol on all clinical strains of C. albicans, including a remarkable inhibitory and fungicidal effect. At postmycostatic concentrations, the eugenol caused partial inhibition of reproduction of the clinical strains of fungi, which was replaced by a subsequent increased cell reproduction rate.\u0000So, the investigation has shown that C. albicans is the dominant species among fungi of the Candida genus in the structure of the microbial profile of otomycoses. The eugenol, emulsified in Polysorbate-80, has a high antifungal effect against clinical strains of C. albicans. At postmycostatic concentrations, the eugenol caused partial inhibition of reproduction of the clinical strains of fungi, which was replaced by a subsequent increase cell reproduction rate.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131178122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21272/eumj.2022;10(1):1-16
A. Kravtsova, V. Pyatikop, Y. Sergiyenko
Introduction. Degenerative disc disease is one of the most common diseases of the musculoskeletal system, characterized by dystrophic changes in the intervertebral disc and vertebral bodies adjacent to it. The main symptoms of this disease are pain and sensory and motor disorders, which, according to various authors, occur in 50–80% of adults. The main objective of the study was to find and implement the optimal set of treatment measures for degenerative disc disease depending on the age of a patient. Materials and Methods. The medical records of inpatients who were treated in the Neurosurgical Department of the Sumy Regional Clinical Hospital in 2019–2020 were analyzed. The course of treatment of 93 patients (61 men and 32 women) was studied. The patients were divided into groups according to their age: young age (under 25) – 13 men and 8 women; middle age (under 60) – 24 men and 19 women; and elderly age (over 60 years) – 18 men and 11 women. The combined use of pathogenetically justified physiotherapeutic measures in the treatment complex is gaining more and more interest. Their distinctive features are physiologic nature, absence of allergic manifestations, the ability to influence most of the pathogenesis of the disease, and the organic combination with other therapeutic factors. Unfortunately, there is an increase in the incidence of temporary incapacitation and progressive course, which often leads to disability and significant financial costs associated with expensive modern methods of diagnosis, treatment, and further provision of employment to patients. The results of our study show that complex treatment including pathogenetic drug therapy, complex paravertebral block, therapeutic physical exercise, and physiotherapy treatment methods provides adequate recovery of spinal function regardless of dystrophic and degenerative changes severity and patient's age. Treatment of degenerative disc disease should be comprehensive and directed at the various symptoms and links of the pathological process.
{"title":"DUROPLASTY: REVIEW OF MATERIALS AND TECHNIQUES","authors":"A. Kravtsova, V. Pyatikop, Y. Sergiyenko","doi":"10.21272/eumj.2022;10(1):1-16","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(1):1-16","url":null,"abstract":"Introduction. Degenerative disc disease is one of the most common diseases of the musculoskeletal system, characterized by dystrophic changes in the intervertebral disc and vertebral bodies adjacent to it. The main symptoms of this disease are pain and sensory and motor disorders, which, according to various authors, occur in 50–80% of adults.\u0000The main objective of the study was to find and implement the optimal set of treatment measures for degenerative disc disease depending on the age of a patient.\u0000Materials and Methods. The medical records of inpatients who were treated in the Neurosurgical Department of the Sumy Regional Clinical Hospital in 2019–2020 were analyzed. The course of treatment of 93 patients (61 men and 32 women) was studied. The patients were divided into groups according to their age: young age (under 25) – 13 men and 8 women; middle age (under 60) – 24 men and 19 women; and elderly age (over 60 years) – 18 men and 11 women.\u0000The combined use of pathogenetically justified physiotherapeutic measures in the treatment complex is gaining more and more interest. Their distinctive features are physiologic nature, absence of allergic manifestations, the ability to influence most of the pathogenesis of the disease, and the organic combination with other therapeutic factors. Unfortunately, there is an increase in the incidence of temporary incapacitation and progressive course, which often leads to disability and significant financial costs associated with expensive modern methods of diagnosis, treatment, and further provision of employment to patients.\u0000The results of our study show that complex treatment including pathogenetic drug therapy, complex paravertebral block, therapeutic physical exercise, and physiotherapy treatment methods provides adequate recovery of spinal function regardless of dystrophic and degenerative changes severity and patient's age.\u0000Treatment of degenerative disc disease should be comprehensive and directed at the various symptoms and links of the pathological process.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131860552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21272/eumj.2022;10(4):318-321
D. Singh, O. Choudhari, S. Spalgais, U. Ojha
Background: Manganese induced autonomic dysfunction is one of the chronic debilitating entities known to be seen primarily in welders exposed to fumes at work place. Welders absorb these fumes via inhalational route. Manganese in these fumes gets deposited in the basal ganglia and cause neuronal loss predominantly in Globus Pallidus. Unfortunately, it is under diagnosed due to lack of awareness of the disease. Though path breaking researches have been carried out in the field of Parkinson’s disease (being main differential diagnosis of manganese toxicity), still very few advancements in the management of manganese toxicity is seen and only supportive therapy is helpful. Primarily, this autonomic dysfunction does not or poorly respond to levodopa which is a characteristic distinguishing factor from Parkinsonism. Case: We are describing a case of a 50-years male presenting with complaints of slowness in the movement, gait instability with frequent falls. The patient has had persistent orthostatic hypotension. He had no significant family history and his work up showed no other cause of autonomic dysfunction. The patient had poor response to Levodopa. He had been exposed to welding fumes for 25 years. His MRI showed non-specific demyelination foci while SPECT scan was normal. The patient was diagnosed with occupational manganese toxicity based on history and Canadian consensus guidelines. The patient improved with oral fludrocortisone and bilateral lower limb elastic stockings. Conclusion: Large scale promotion on the use of Personal Protective equipment (PPE) is required. Early intervention in these cases could save the patient from detrimental effect, decrease social economic burden and make better health related quality of life as only supportive care can be given once diagnosed.
{"title":"AUTONOMIC DYSFUNCTION IN A WELDER FOLLOWING MANGANESE TOXICITY: A CASE REPORT","authors":"D. Singh, O. Choudhari, S. Spalgais, U. Ojha","doi":"10.21272/eumj.2022;10(4):318-321","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(4):318-321","url":null,"abstract":"Background: Manganese induced autonomic dysfunction is one of the chronic debilitating entities known to be seen primarily in welders exposed to fumes at work place. Welders absorb these fumes via inhalational route. Manganese in these fumes gets deposited in the basal ganglia and cause neuronal loss predominantly in Globus Pallidus. Unfortunately, it is under diagnosed due to lack of awareness of the disease. Though path breaking researches have been carried out in the field of Parkinson’s disease (being main differential diagnosis of manganese toxicity), still very few advancements in the management of manganese toxicity is seen and only supportive therapy is helpful. Primarily, this autonomic dysfunction does not or poorly respond to levodopa which is a characteristic distinguishing factor from Parkinsonism.\u0000Case: We are describing a case of a 50-years male presenting with complaints of slowness in the movement, gait instability with frequent falls. The patient has had persistent orthostatic hypotension. He had no significant family history and his work up showed no other cause of autonomic dysfunction. The patient had poor response to Levodopa. He had been exposed to welding fumes for 25 years. His MRI showed non-specific demyelination foci while SPECT scan was normal. The patient was diagnosed with occupational manganese toxicity based on history and Canadian consensus guidelines. The patient improved with oral fludrocortisone and bilateral lower limb elastic stockings.\u0000Conclusion: Large scale promotion on the use of Personal Protective equipment (PPE) is required. Early intervention in these cases could save the patient from detrimental effect, decrease social economic burden and make better health related quality of life as only supportive care can be given once diagnosed.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"41 8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133351961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21272/eumj.2023;11(2):155-163
O. Kolomiiets, R. Moskalenko
Introduction. Breast cancer (BC) is a significant medical and social problem, as it is the leading cause of cancer-related mortality in women worldwide. Microcalcifications in the breast tissue are essential in developing the pathological process and affect the prognosis and metastasis. The tumor microenvironment consists of cancer cells and stromal cells such as fibroblasts, endothelial cells, pericytes, and immune cells, including M1 and M2 macrophages. The work aims to study the influence of microcalcifications on the polarization of macrophages in the tumor microenvironment of BC. Materials and methods. The study was conducted on 60 samples of BC, divided into 30 samples of BC with microcalcifications (group I) and a control group of 30 samples of BC without calcifications (group II). All microcalcifications met the criterion of size up to ≤1 mm. To study the pathohistological changes, BC's tissue was analyzed using macroscopic description, histology, and immunohistochemical study with antibodies against CD68 and CD163. Results. According to the results of an immunohistochemical study, it was found that the expression of CD68-positive macrophages of the M1 type is significantly higher in the tissue of samples of BC with microcalcifications, compared to samples of the control group (60.85 ± 2.71 cells in the field of view vs. 51.14 ± 2.89, p < 0.05). On the other hand, it was established that the average value of CD163 expression in group I was 53.21 ± 3.05 against 65.57 ± 3.75 (p ˂ 0.05) cells in the group of BC without calcification. Nevertheless, the localization of M1 and M2 macrophages in the tumor had standard features and did not differ. A possible mechanism of the effect of microcalcifications on the polarization of macrophages is their support of chronic inflammation in cancer tissues and, thus, the development of pro-inflammatory M1 phenotype in macrophages. Further studies are needed to obtain more unambiguous conclusions.
{"title":"IMMUNOHISTOCHEMICAL STUDY OF M1 AND M2 MACROPHAGES IN BREAST CANCER WITH MICROCALCIFICATIONS","authors":"O. Kolomiiets, R. Moskalenko","doi":"10.21272/eumj.2023;11(2):155-163","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(2):155-163","url":null,"abstract":"Introduction. Breast cancer (BC) is a significant medical and social problem, as it is the leading cause of cancer-related mortality in women worldwide. Microcalcifications in the breast tissue are essential in developing the pathological process and affect the prognosis and metastasis. The tumor microenvironment consists of cancer cells and stromal cells such as fibroblasts, endothelial cells, pericytes, and immune cells, including M1 and M2 macrophages.\u0000The work aims to study the influence of microcalcifications on the polarization of macrophages in the tumor microenvironment of BC.\u0000Materials and methods. The study was conducted on 60 samples of BC, divided into 30 samples of BC with microcalcifications (group I) and a control group of 30 samples of BC without calcifications (group II). All microcalcifications met the criterion of size up to ≤1 mm. To study the pathohistological changes, BC's tissue was analyzed using macroscopic description, histology, and immunohistochemical study with antibodies against CD68 and CD163.\u0000Results. According to the results of an immunohistochemical study, it was found that the expression of CD68-positive macrophages of the M1 type is significantly higher in the tissue of samples of BC with microcalcifications, compared to samples of the control group (60.85 ± 2.71 cells in the field of view vs. 51.14 ± 2.89, p < 0.05). On the other hand, it was established that the average value of CD163 expression in group I was 53.21 ± 3.05 against 65.57 ± 3.75 (p ˂ 0.05) cells in the group of BC without calcification. Nevertheless, the localization of M1 and M2 macrophages in the tumor had standard features and did not differ.\u0000A possible mechanism of the effect of microcalcifications on the polarization of macrophages is their support of chronic inflammation in cancer tissues and, thus, the development of pro-inflammatory M1 phenotype in macrophages. Further studies are needed to obtain more unambiguous conclusions.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132162552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21272/eumj.2022;10(2):182-187
O. Chernatska, Adeleke Oluwaseun Dorcas, N. O. Opolonska
Introduction. Situation in Ukraine nowadays stimulates teachers to provide distance learning during practical classes. A lot of foreign students are able to do calculation online. It is reasonable to ask them about advantages and disadvantages of such method for further improvement of study process. The aim is the determination of peculiarities of using online calculators among fifth year medical students. Materials and Methods. We included 60 fifth year foreign medical students who studied online during 2021 year (the main group) and 54 students who learned internal medicine offline during 2019 (the control group) in our trial. Questionnaires were given to all of them at the last class of internal medicine. Most participants (54) from the main group and all participants from the control group have answered about the peculiarities of using online calculators during the process of study, advantages and disadvantages of such method. The results were analyzed by Microsoft Excel and GraphPad Prism. Results. During distance learning of internal medicine at Sumy State University, the number of 5th year students who evaluated results online increased from 12 (22,2 %) to 44 (81,5 %). 46 subjects from the main group (85 %) used online calculators for cardiology, 32 (59 %) – for nephrology and 22 (39 %) – for rheumatology. A big percent of participants from the main (81.5 %) group and the control (50 %) group planned to use online calculators in their future professional activities. In the opinion of most participants from the main group (81.5 %), the main benefit was fast evaluation, which helped to save time. About quarter of them (24 %) decided that such method made learning easier and more effective. A fifth part of students (20 %) determined that more accurate calculation was the most important advantage. Conclusions. During distance learning of internal medicine at Sumy State University, the number of students who did online calculation increased by four times which showed that teachers widely provided the method. In the opinion of majority of foreign students, dependence of internet connection was the main disadvantage of online calculators, while the benefits of this method were: fast, more accurate evaluation, making learning easier and effective.
{"title":"PECULIARITIES OF ONLINE CALCULATORS USAGE DURING DISTANCE LEARNING AT SUMY STATE UNIVERSITY AMONG 5TH YEAR STUDENTS OF MEDICAL INSTITUTE","authors":"O. Chernatska, Adeleke Oluwaseun Dorcas, N. O. Opolonska","doi":"10.21272/eumj.2022;10(2):182-187","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(2):182-187","url":null,"abstract":"Introduction. Situation in Ukraine nowadays stimulates teachers to provide distance learning during practical classes. A lot of foreign students are able to do calculation online. It is reasonable to ask them about advantages and disadvantages of such method for further improvement of study process.\u0000The aim is the determination of peculiarities of using online calculators among fifth year medical students.\u0000Materials and Methods. We included 60 fifth year foreign medical students who studied online during 2021 year (the main group) and 54 students who learned internal medicine offline during 2019 (the control group) in our trial. Questionnaires were given to all of them at the last class of internal medicine. Most participants (54) from the main group and all participants from the control group have answered about the peculiarities of using online calculators during the process of study, advantages and disadvantages of such method. The results were analyzed by Microsoft Excel and GraphPad Prism.\u0000Results. During distance learning of internal medicine at Sumy State University, the number of 5th year students who evaluated results online increased from 12 (22,2 %) to 44 (81,5 %). 46 subjects from the main group (85 %) used online calculators for cardiology, 32 (59 %) – for nephrology and 22 (39 %) – for rheumatology. A big percent of participants from the main (81.5 %) group and the control (50 %) group planned to use online calculators in their future professional activities. In the opinion of most participants from the main group (81.5 %), the main benefit was fast evaluation, which helped to save time. About quarter of them (24 %) decided that such method made learning easier and more effective. A fifth part of students (20 %) determined that more accurate calculation was the most important advantage.\u0000Conclusions. During distance learning of internal medicine at Sumy State University, the number of students who did online calculation increased by four times which showed that teachers widely provided the method. In the opinion of majority of foreign students, dependence of internet connection was the main disadvantage of online calculators, while the benefits of this method were: fast, more accurate evaluation, making learning easier and effective.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133947565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：