Maulana Bagus Adi Cahyono, Ilham Rahmanto, Zahras Azimuth Doman, Galuh Senjani Yulfani Putri, Christopher Surya Lodianto, P. Z. Romadhon
The global population living with Parkinson’s disease is estimated to reach 9.4 million people, which has increased significantly since 2016, with a total of 6 million people. Parkinson's is a neurodegenerative disease of the substantia nigra that causes a decrease in dopamine production and is characterized by the appearance of cytoplasmic misfold proteins called Lewy bodies. The study found that abnormalities or mutations in the SNCA and LRRK2 genes correlated with the overproduction of the ɑ-synuclein protein, which forms Lewy bodies that cause Parkinson's. Current Parkinson's medications only temporarily replace lost dopamine but do not treat the direct cause of Parkinson's; this research used qualitative literature study with content analysis, observation, and development; the use of CRISPR-Cas9 through AAV genetic engineering in repairing SNCA and LRRK2 mutant gene. This genetic therapy works by cutting the mutant DNA base sequences in the SNCA and LRRK2 genes and then replacing them with normal sequences through a homology-direct repair mechanism. As a result, the abnormalities or mutations that cause Parkinson's in these two genes can be corrected, so that dopaminergic levels in the brain can return to normal and excessive accumulation of α-synuclein protein can be suppressed.
{"title":"CRISPR-Cas9 through AAV delivery system as a gene therapy in Parkinson’s disease","authors":"Maulana Bagus Adi Cahyono, Ilham Rahmanto, Zahras Azimuth Doman, Galuh Senjani Yulfani Putri, Christopher Surya Lodianto, P. Z. Romadhon","doi":"10.30651/jqm.v7i2.16117","DOIUrl":"https://doi.org/10.30651/jqm.v7i2.16117","url":null,"abstract":"The global population living with Parkinson’s disease is estimated to reach 9.4 million people, which has increased significantly since 2016, with a total of 6 million people. Parkinson's is a neurodegenerative disease of the substantia nigra that causes a decrease in dopamine production and is characterized by the appearance of cytoplasmic misfold proteins called Lewy bodies. The study found that abnormalities or mutations in the SNCA and LRRK2 genes correlated with the overproduction of the ɑ-synuclein protein, which forms Lewy bodies that cause Parkinson's. Current Parkinson's medications only temporarily replace lost dopamine but do not treat the direct cause of Parkinson's; this research used qualitative literature study with content analysis, observation, and development; the use of CRISPR-Cas9 through AAV genetic engineering in repairing SNCA and LRRK2 mutant gene. This genetic therapy works by cutting the mutant DNA base sequences in the SNCA and LRRK2 genes and then replacing them with normal sequences through a homology-direct repair mechanism. As a result, the abnormalities or mutations that cause Parkinson's in these two genes can be corrected, so that dopaminergic levels in the brain can return to normal and excessive accumulation of α-synuclein protein can be suppressed.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76429968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Foreign bodies in the larynx are reported quite rarely, with a prevalence of around 4% among patients, especially geriatrics, and represent an acute airway emergency with significant morbidity and mortality rate. Objective: This case report aimed to provide information on managing the extraction of foreign bodies and the accompanying problems. Discussion: A 49-year-old man with a history of wearing dentures was admitted to the emergency room. The patient complained of a hoarse voice upon waking up, painful swallowing, and a lumpy sensation in his throat, but he had no chest pain, cough, nausea, or vomiting. An indirect laryngoscopy examination revealed a foreign body lodged in the anterior rima glottis, impeding the mobility of the vocal folds. Under general anesthesia, emergency direct laryngoscopy, evacuation, and tracheoscopy were performed. It was observed that a foreign denture body was lodged in the larynx and was evacuated using grasping forceps. Post-evacuation, the vocal folds were swollen, with a false vocal fold hematoma, posterior subglottic laceration, and no active bleeding. Conclusion: Foreign bodies in the larynx must be prompted and gently removed because it leads to life-threatening. In suspected swallowed foreign bodies, plain radiographs are the initial imaging approach. Inhalational or intravenous induction is operated to administer the general anesthetic, along with the maintenance of spontaneous ventilation.
{"title":"An Unusual Laryngeal Foreign Body in Adult: Denture","authors":"Deoni Daniswara, Rizka Fakhriani","doi":"10.30651/jqm.v7i2.13984","DOIUrl":"https://doi.org/10.30651/jqm.v7i2.13984","url":null,"abstract":"Background: Foreign bodies in the larynx are reported quite rarely, with a prevalence of around 4% among patients, especially geriatrics, and represent an acute airway emergency with significant morbidity and mortality rate. Objective: This case report aimed to provide information on managing the extraction of foreign bodies and the accompanying problems. Discussion: A 49-year-old man with a history of wearing dentures was admitted to the emergency room. The patient complained of a hoarse voice upon waking up, painful swallowing, and a lumpy sensation in his throat, but he had no chest pain, cough, nausea, or vomiting. An indirect laryngoscopy examination revealed a foreign body lodged in the anterior rima glottis, impeding the mobility of the vocal folds. Under general anesthesia, emergency direct laryngoscopy, evacuation, and tracheoscopy were performed. It was observed that a foreign denture body was lodged in the larynx and was evacuated using grasping forceps. Post-evacuation, the vocal folds were swollen, with a false vocal fold hematoma, posterior subglottic laceration, and no active bleeding. Conclusion: Foreign bodies in the larynx must be prompted and gently removed because it leads to life-threatening. In suspected swallowed foreign bodies, plain radiographs are the initial imaging approach. Inhalational or intravenous induction is operated to administer the general anesthetic, along with the maintenance of spontaneous ventilation.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75224540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ninuk Dwi Ariningtyas, Putri Aqila, E. Prasetya, Roni Subagyo
Perinatal depression is a feeling disorder that occurs in a woman during pregnancy and after childbirth. Perinatal depression can be seen from various factors, one of which is personality traits. This study aims to determine the relationship of personality traits with perinatal depression at Muhammadiyah Hospital Surabaya. This study was observative analytic using a cross-sectional approach, conducted on 96 respondents using the Edinburgh Postnatal Depression Scale (EPDS) and the OCEAN personality trait questionnaire. The result of the multiple linear statistical tests on the F test is p=0.00 (p<0.05), the t-test on the extraversion personality trait is p=0.031 (p<0.05), and the neuroticism personality trait is p=0.000 (p<0.05). The coefficient of determination test R2= 37.0%. In conclusion, there is a relationship between personality traits and perinatal depression at Muhammadiyah Surabaya Hospital.
{"title":"Relationship between personality traits and perinatal depression at Muhammadiyah Hospital Surabaya","authors":"Ninuk Dwi Ariningtyas, Putri Aqila, E. Prasetya, Roni Subagyo","doi":"10.30651/jqm.v7i2.17634","DOIUrl":"https://doi.org/10.30651/jqm.v7i2.17634","url":null,"abstract":"Perinatal depression is a feeling disorder that occurs in a woman during pregnancy and after childbirth. Perinatal depression can be seen from various factors, one of which is personality traits. This study aims to determine the relationship of personality traits with perinatal depression at Muhammadiyah Hospital Surabaya. This study was observative analytic using a cross-sectional approach, conducted on 96 respondents using the Edinburgh Postnatal Depression Scale (EPDS) and the OCEAN personality trait questionnaire. The result of the multiple linear statistical tests on the F test is p=0.00 (p<0.05), the t-test on the extraversion personality trait is p=0.031 (p<0.05), and the neuroticism personality trait is p=0.000 (p<0.05). The coefficient of determination test R2= 37.0%. In conclusion, there is a relationship between personality traits and perinatal depression at Muhammadiyah Surabaya Hospital.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87558946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atika Widyaningrum, Mega Pandu Arfiyanti, K. Ratnaningrum
Capabilities to diagnose diseases caused by parasites is one of the competencies that must be mastered by general practitioners. This is stated in Standar Kompetensi Dokter Indonesia (SKDI). The branch of parasitology includes protozoa, helminths, and arthropods. Competency can be achieved through debriefing activities and laboratory sessions. During the pandemic, laboratory sessions of parasitology are carried out online with modification of implementation techniques. The study aims to determine the differences in scores between online and offline laboratory sessions of parasitology in medical faculty. Quantitative research used a quasi-experimental method, with a simple random sampling technique. The research data used secondary data scores of laboratory sessions of helminth and protozoa parasitology of Medical students in Universitas Muhammadiyah Semarang (Unimus). Data were analyzed by using a non-parametric Mann-Whitney u-test. From 62 students, there were significant differences in scores between online and offline helminth laboratory sessions (p=0.00) with the average scores of online helminth courses higher than offline laboratory sessions (70.6±19.8). There was no significant difference in grades of online and offline protozoa laboratory sessions (p=0.576) with average scores of online protozoa courses being lower than the offline laboratory session (55.8±25.5). There is a significant difference in scores between the helminth laboratory session of parasitology and there is no difference in scores between the protozoa laboratory session in Medical Faculty.
{"title":"Differences score between online and offline laboratory sessions of parasitology in Medical Faculty","authors":"Atika Widyaningrum, Mega Pandu Arfiyanti, K. Ratnaningrum","doi":"10.30651/jqm.v7i2.12368","DOIUrl":"https://doi.org/10.30651/jqm.v7i2.12368","url":null,"abstract":"Capabilities to diagnose diseases caused by parasites is one of the competencies that must be mastered by general practitioners. This is stated in Standar Kompetensi Dokter Indonesia (SKDI). The branch of parasitology includes protozoa, helminths, and arthropods. Competency can be achieved through debriefing activities and laboratory sessions. During the pandemic, laboratory sessions of parasitology are carried out online with modification of implementation techniques. The study aims to determine the differences in scores between online and offline laboratory sessions of parasitology in medical faculty. Quantitative research used a quasi-experimental method, with a simple random sampling technique. The research data used secondary data scores of laboratory sessions of helminth and protozoa parasitology of Medical students in Universitas Muhammadiyah Semarang (Unimus). Data were analyzed by using a non-parametric Mann-Whitney u-test. From 62 students, there were significant differences in scores between online and offline helminth laboratory sessions (p=0.00) with the average scores of online helminth courses higher than offline laboratory sessions (70.6±19.8). There was no significant difference in grades of online and offline protozoa laboratory sessions (p=0.576) with average scores of online protozoa courses being lower than the offline laboratory session (55.8±25.5). There is a significant difference in scores between the helminth laboratory session of parasitology and there is no difference in scores between the protozoa laboratory session in Medical Faculty.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90087155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Ihwan Narwanto, Siti Jamalia, Yuli Hermansyah
Insecticides are the most widely used type of pesticide in various fields, such as agriculture, plantation, industry, and household activities. Only 1% of the insecticides used work effectively to attack the target and the remaining 99% are released freely into water, soil, and air and finally have an impact on non-target organisms. Chlorpyrifos, carbofuran, and cypermethrin were the most widely used insecticides in their respective groups, namely, organophosphates, carbamates, and pyrethroids. This study aims to determine the changes in histopathological features of adolescent rat livers due to subchronic exposure to chlorpyrifos, carbofuran, and cypermethrin. Adolescent livers have a faster regeneration rate but are more susceptible to damage than the older age group. This study used 30 male Wistar rats which were divided into 5 groups, namely, normal group (N), control group (K), chlorpyrifos group (P1), carbofuran group (P2), and cypermethrin group (P3). Subcutaneous injection of insecticide was carried out for 21 days. The scoring method used in the histopathological observations is Manja Roenigk score. Data analysis used the ANOVA test and continued with the LSD post hoc test. In this study, significant results were obtained, P<0.05, which indicated that there were significant differences in the histopathological features of the liver that were exposed to chlorpyrifos, carbofuran, and cypermethrin. The picture of liver damage was mostly found in the carbofuran group.
{"title":"Changes in histopathological features of adolescent rat livers due to subchronic exposure to Chlorpyrifos, Carbofuran, and Cypermethrin","authors":"Muhammad Ihwan Narwanto, Siti Jamalia, Yuli Hermansyah","doi":"10.30651/jqm.v7i2.16880","DOIUrl":"https://doi.org/10.30651/jqm.v7i2.16880","url":null,"abstract":"Insecticides are the most widely used type of pesticide in various fields, such as agriculture, plantation, industry, and household activities. Only 1% of the insecticides used work effectively to attack the target and the remaining 99% are released freely into water, soil, and air and finally have an impact on non-target organisms. Chlorpyrifos, carbofuran, and cypermethrin were the most widely used insecticides in their respective groups, namely, organophosphates, carbamates, and pyrethroids. This study aims to determine the changes in histopathological features of adolescent rat livers due to subchronic exposure to chlorpyrifos, carbofuran, and cypermethrin. Adolescent livers have a faster regeneration rate but are more susceptible to damage than the older age group. This study used 30 male Wistar rats which were divided into 5 groups, namely, normal group (N), control group (K), chlorpyrifos group (P1), carbofuran group (P2), and cypermethrin group (P3). Subcutaneous injection of insecticide was carried out for 21 days. The scoring method used in the histopathological observations is Manja Roenigk score. Data analysis used the ANOVA test and continued with the LSD post hoc test. In this study, significant results were obtained, P<0.05, which indicated that there were significant differences in the histopathological features of the liver that were exposed to chlorpyrifos, carbofuran, and cypermethrin. The picture of liver damage was mostly found in the carbofuran group.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90960632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arif Gunawan, Annas Adimara, Ayu Tsalis Saputri, Azalika Kansa Namira, Bela Auliya Puspita Ningrum, E. Prasetya
Schizophrenia is a mental disorder that triggers the occurrence of impaired function in the human brain, behavior, cognitive, and emotional functions. This disorder has become a problem in the study of mental health, which must be treated comprehensively by using empirical treatment combined with rehabilitation. Hopefully, increasing the maximum level of healing and reducing recurrence rates can improve social function and quality of life. Thus, this review aims to narrate the model and effective community-based psychosocial rehabilitation center. The articles of the studies published from 2017-2021 were collected and analyzed in this literature review. The keywords used were community-based rehabilitation for schizophrenia. The results show that in addition to pharmacological therapy, six community-based psychosocial non-pharmacological therapy methods are considered effective for intervention in patients with schizophrenia. The methods are club methods in elderly schizophrenic patients, community-based methods, direct patient decision-making methods, case and club management methods, psychoeducational and social skills methods, and community care unit methods. All of the above methods analyzed showed significant effectiveness in community-based psychosocial rehabilitation treatment in developing countries.
{"title":"Community-based psychosocial rehabilitation model for people with schizophrenia","authors":"Arif Gunawan, Annas Adimara, Ayu Tsalis Saputri, Azalika Kansa Namira, Bela Auliya Puspita Ningrum, E. Prasetya","doi":"10.30651/jqm.v7i1.10574","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.10574","url":null,"abstract":"Schizophrenia is a mental disorder that triggers the occurrence of impaired function in the human brain, behavior, cognitive, and emotional functions. This disorder has become a problem in the study of mental health, which must be treated comprehensively by using empirical treatment combined with rehabilitation. Hopefully, increasing the maximum level of healing and reducing recurrence rates can improve social function and quality of life. Thus, this review aims to narrate the model and effective community-based psychosocial rehabilitation center. The articles of the studies published from 2017-2021 were collected and analyzed in this literature review. The keywords used were community-based rehabilitation for schizophrenia. The results show that in addition to pharmacological therapy, six community-based psychosocial non-pharmacological therapy methods are considered effective for intervention in patients with schizophrenia. The methods are club methods in elderly schizophrenic patients, community-based methods, direct patient decision-making methods, case and club management methods, psychoeducational and social skills methods, and community care unit methods. All of the above methods analyzed showed significant effectiveness in community-based psychosocial rehabilitation treatment in developing countries.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"427 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77860491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intraocular foreign bodies (IOFBs) were 16-40% of open globe trauma and could cause severe visual loss. Therefore, they require immediate diagnosis and treatment. This is a case of an 18-year-old man who came to the hospital complaining of a metal piercing in his left eye while cutting some metal about 2 hours before entering the hospital. On ophthalmologic examination, visual acuity of the left eye was 3/60, and a full-thickness laceration of the cornea with an IOFB was seen at the anterior chamber base. Immediate IOFB evacuation was carried out on the same day as the incident happened. During the operation, a metal intraocular foreign body with a sharp tip, 4x2x1 mm in size, was successfully removed in intact condition. Next, the laceration and the corneal limbus incision were sutured using 10.0 nylon. The stitches are tight, and the anterior chamber depth is maintained. Evaluation on the fourth week after IOFB evacuation showed that visual acuity in the left eye was 6/20 with lens correction C-1.50 x 150° become 6/7.5. Appropriate and prompt diagnosis and management of open eye injury can contribute to preserving a good anatomical and functional result.
眼内异物(IOFBs)占开眼外伤的16-40%，可导致严重的视力丧失。因此，他们需要立即诊断和治疗。这是一名18岁的男子，在入院前2小时左右，他在切割金属时左眼被金属刺穿，来到医院。眼科检查，左眼视力为3/60，在前房基底见全层角膜裂伤伴IOFB。事故发生当天，IOFB立即进行了疏散。手术过程中，成功取出一个4 × 2x1 mm大小的尖锐金属眼内异物。然后用10.0尼龙缝合裂口和角膜边缘切口。缝线很紧，保持前房深度。摘除IOFB后第四周评价左眼视力为6/20，晶状体矫正C-1.50 x 150°变为6/7.5。适当和及时的诊断和治疗有助于保持良好的解剖和功能结果。
{"title":"Intraocular foreign body (IOFB)","authors":"Ahmad Ikliluddin, Listya Normalita","doi":"10.30651/jqm.v7i1.14260","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.14260","url":null,"abstract":"Intraocular foreign bodies (IOFBs) were 16-40% of open globe trauma and could cause severe visual loss. Therefore, they require immediate diagnosis and treatment. This is a case of an 18-year-old man who came to the hospital complaining of a metal piercing in his left eye while cutting some metal about 2 hours before entering the hospital. On ophthalmologic examination, visual acuity of the left eye was 3/60, and a full-thickness laceration of the cornea with an IOFB was seen at the anterior chamber base. Immediate IOFB evacuation was carried out on the same day as the incident happened. During the operation, a metal intraocular foreign body with a sharp tip, 4x2x1 mm in size, was successfully removed in intact condition. Next, the laceration and the corneal limbus incision were sutured using 10.0 nylon. The stitches are tight, and the anterior chamber depth is maintained. Evaluation on the fourth week after IOFB evacuation showed that visual acuity in the left eye was 6/20 with lens correction C-1.50 x 150° become 6/7.5. Appropriate and prompt diagnosis and management of open eye injury can contribute to preserving a good anatomical and functional result.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85427492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eni Sumarliyah, I. Purnamasari, A. Susanty, P. F. Wiliyanarti, F. Firman
Vaccination in the context of dealing with COVID-19 has been promoted. The increasing number of cases showed the lack of community compliance in preventing the transmission of COVID-19 after Vaccination. Intrapersonal factors, such as changes in individual behavior, were the main focus of breaking the chain of the spread of COVID-19. This study aimed to determine the effectiveness of providing health education with animated video media on improving COVID-19 prevention behavior after Vaccination among students at the Karangasem Islamic Boarding School Paciran of Lamongan. This study used pre-experimental with one group pre-test and post-test design. The population was Muhammadiyah Islamic boarding school students in Karangasem Paciran Lamongan, which amounted to 460 and took samples of 332 people using a non-probability purposive sampling technique. The research instrument used a questionnaire 30 items. The results of knowledge have increased from pre-test sufficient knowledge (60.84%), and post-test good knowledge (81.02%) using the Wilcoxon signed rank test p=0.000 (<0.05). The results of attitudes have increased from pre-test negative attitude (70.78%) and post-test positive attitude (76.81%) using the Chi-square test p=0.001 (<0.05). The results of practice have increased from pre-test sufficient practice (62.95%), and post-test good practice (77.71%) using the Wilcoxon signed rank test p=0.000 (<0.05). In conclusion, the video animation media of health education was proven to increase post-vaccination COVID-19 prevention behavior among students at the Karangasem Islamic Boarding School Paciran of Lamongan.
{"title":"The effectiveness of health education provision of animated video media in improving COVID-19 prevention behavior post-vaccination among students of Muhammadiyah Islamic Boarding School Karangasem Paciran Lamongan","authors":"Eni Sumarliyah, I. Purnamasari, A. Susanty, P. F. Wiliyanarti, F. Firman","doi":"10.30651/jqm.v7i1.14541","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.14541","url":null,"abstract":"Vaccination in the context of dealing with COVID-19 has been promoted. The increasing number of cases showed the lack of community compliance in preventing the transmission of COVID-19 after Vaccination. Intrapersonal factors, such as changes in individual behavior, were the main focus of breaking the chain of the spread of COVID-19. This study aimed to determine the effectiveness of providing health education with animated video media on improving COVID-19 prevention behavior after Vaccination among students at the Karangasem Islamic Boarding School Paciran of Lamongan. This study used pre-experimental with one group pre-test and post-test design. The population was Muhammadiyah Islamic boarding school students in Karangasem Paciran Lamongan, which amounted to 460 and took samples of 332 people using a non-probability purposive sampling technique. The research instrument used a questionnaire 30 items. The results of knowledge have increased from pre-test sufficient knowledge (60.84%), and post-test good knowledge (81.02%) using the Wilcoxon signed rank test p=0.000 (<0.05). The results of attitudes have increased from pre-test negative attitude (70.78%) and post-test positive attitude (76.81%) using the Chi-square test p=0.001 (<0.05). The results of practice have increased from pre-test sufficient practice (62.95%), and post-test good practice (77.71%) using the Wilcoxon signed rank test p=0.000 (<0.05). In conclusion, the video animation media of health education was proven to increase post-vaccination COVID-19 prevention behavior among students at the Karangasem Islamic Boarding School Paciran of Lamongan.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89344596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jelita Aprisano Putri, Nabilla Feirizky Chairunnisa, H. Arwati, Hartono Kahar
Malaria is a parasitic infectious disease that remains one of the focuses of world health problems. The ethanol extract of Hedyotis corymbosa has biochemical compounds potentially become a new antimalarial drug. This study aimed to analyze the effect of this extract on parasitemia and hepatomegaly in mice infected with Plasmodium berghei ANKA. Twentyfive BALB/c mice were infected with P. berghei ANKA and grouped into 5 groups. Group 1-3 were treated with 250 mg/Kg BW (HC250), 300 mg/Kg BW (HC300), and 350 mg/Kg BW (HC350) of ethanol extract of H. corymbosa (EEHC), respectively. Group 4 was a positive control (POS) which was given dihydroartemisisnin-piperaquin (DHP) and Group 5 was a negative control (NEG) which was only given CMC Na 1%. Treatments were given orally once a day for four consecutive days. Parasitemia was observed daily on Giemsa-stained tail blood smear. On day 5 the mice were sacrificed, blood were collected by cardiac punctured, the livers were removed and the length, width, and weight were measured. There was no significant difference on parasitemia between Group 1, 2, 3 and NEG. However, the highest inhibition of parasite s growth was found in Group 3 (61.4%. Observation on hepatomegaly, showed that a significant difference on the length of the liver was found between Group 3 and NEG.
{"title":"Effect of ethanol extract of Hedyotis corymbosa (L.) Lamk against parasitemia and hepatomegaly in Plasmodium berghei ANKA-infected mice","authors":"Jelita Aprisano Putri, Nabilla Feirizky Chairunnisa, H. Arwati, Hartono Kahar","doi":"10.30651/jqm.v7i1.15903","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.15903","url":null,"abstract":"Malaria is a parasitic infectious disease that remains one of the focuses of world health problems. The ethanol extract of Hedyotis corymbosa has biochemical compounds potentially become a new antimalarial drug. This study aimed to analyze the effect of this extract on parasitemia and hepatomegaly in mice infected with Plasmodium berghei ANKA. Twentyfive BALB/c mice were infected with P. berghei ANKA and grouped into 5 groups. Group 1-3 were treated with 250 mg/Kg BW (HC250), 300 mg/Kg BW (HC300), and 350 mg/Kg BW (HC350) of ethanol extract of H. corymbosa (EEHC), respectively. Group 4 was a positive control (POS) which was given dihydroartemisisnin-piperaquin (DHP) and Group 5 was a negative control (NEG) which was only given CMC Na 1%. Treatments were given orally once a day for four consecutive days. Parasitemia was observed daily on Giemsa-stained tail blood smear. On day 5 the mice were sacrificed, blood were collected by cardiac punctured, the livers were removed and the length, width, and weight were measured. There was no significant difference on parasitemia between Group 1, 2, 3 and NEG. However, the highest inhibition of parasite s growth was found in Group 3 (61.4%. Observation on hepatomegaly, showed that a significant difference on the length of the liver was found between Group 3 and NEG.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90599128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic has been going on for more than two years. The number of sufferers of this disease continues to increase as well as those who die. The number of disease and death cases varies in each country and even in one country in certain seasons and certain tribes. This is triggered by the evolution of viruses that create new variants with different virulences so that they can affect the transmission of the COVID-19 virus. Several factors can trigger the evolution of the virus, one of which is the ability to mutate to create new variants and/or new strains that cause differences in morbidity and mortality due to early COVID-19 strains. Other factors that favor viral evolution are the reservoir, host immunity, and extreme environmental conditions. This is supported by differences in the percentage of morbidity and mortality in various countries. This literature review aims to determine the effect of viral, reservoir, host, and environmental factors (season and rainfall, temperature, sunlight, materials around the environment, animal habitat, water, and wastewater) on the evolution of viruses that affect morbidity and mortality in COVID-19 disease.
{"title":"Effect of viral, reservoir, host, and environmental factors on viral evolution that affect morbidity and mortality of COVID-19 disease","authors":"Jemima Lewi Santoso","doi":"10.30651/jqm.v7i1.12575","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.12575","url":null,"abstract":"The COVID-19 pandemic has been going on for more than two years. The number of sufferers of this disease continues to increase as well as those who die. The number of disease and death cases varies in each country and even in one country in certain seasons and certain tribes. This is triggered by the evolution of viruses that create new variants with different virulences so that they can affect the transmission of the COVID-19 virus. Several factors can trigger the evolution of the virus, one of which is the ability to mutate to create new variants and/or new strains that cause differences in morbidity and mortality due to early COVID-19 strains. Other factors that favor viral evolution are the reservoir, host immunity, and extreme environmental conditions. This is supported by differences in the percentage of morbidity and mortality in various countries. This literature review aims to determine the effect of viral, reservoir, host, and environmental factors (season and rainfall, temperature, sunlight, materials around the environment, animal habitat, water, and wastewater) on the evolution of viruses that affect morbidity and mortality in COVID-19 disease.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87292008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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