Eka Noviya Fuzianingsih, C. Callixte, Marselaonety La’lang, D. E. Putri, H. Arwati, L. T. Suwanti
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is characterized by extensive infiltration of leukocytes, microhemorrhages, vasogenic edema, changes in lung color, and a significant increase in the weight of the lung. This study was aimed to find out the differences in parasitemia and lung size in MA-ARDSand non-MA-ARDSin mice infected with Plasmodium berghei ANKA. Sixteen male BALB/c mice were infected with P. berghei ANKA, and daily parasitemia was observed on Giemsa-stained tail blood smears. Mice were sacrificed when parasitemia reached ±20%. Simultaneously eight uninfected mice were used as negative control (NEG). The statistical analysis was done using Kruskal Wallis, Mann Whitney U tests, and Spearman correlation test. The results showed that there were significant differences in parasitemia (p=0.001), weight (p=0.001), and lung length (p=0.021) between the MA-ARDS and non-MA-ARDS groups. Comparison of NEG and MA-ARDS resulted in a significant difference in lung size (p=0.05). When non-MA-ARDScompared with NEG groups, it showed a significant difference in lung width (p=0.001). However, there was no significant difference in lung weight and length (p>0.05). Spearman correlation test showed that there was a strong correlation between parasitemia with weight (p=0.000), length (p=0.001), and lung width (p=0.017). The findings indicated that parasitemia played a role in the development of MA-ARDS in mice infected with P. berghei ANKA and influenced the size of the lung.
{"title":"The differences of parasitemia and lungs size in malaria-associated acute respiratory distress syndrome (MA-ARDS) and non-MA-ARDS in mice infected with Plasmodium berghei ANKA","authors":"Eka Noviya Fuzianingsih, C. Callixte, Marselaonety La’lang, D. E. Putri, H. Arwati, L. T. Suwanti","doi":"10.30651/jqm.v6i1.8853","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.8853","url":null,"abstract":"Malaria-associated acute respiratory distress syndrome (MA-ARDS) is characterized by extensive infiltration of leukocytes, microhemorrhages, vasogenic edema, changes in lung color, and a significant increase in the weight of the lung. This study was aimed to find out the differences in parasitemia and lung size in MA-ARDSand non-MA-ARDSin mice infected with Plasmodium berghei ANKA. Sixteen male BALB/c mice were infected with P. berghei ANKA, and daily parasitemia was observed on Giemsa-stained tail blood smears. Mice were sacrificed when parasitemia reached ±20%. Simultaneously eight uninfected mice were used as negative control (NEG). The statistical analysis was done using Kruskal Wallis, Mann Whitney U tests, and Spearman correlation test. The results showed that there were significant differences in parasitemia (p=0.001), weight (p=0.001), and lung length (p=0.021) between the MA-ARDS and non-MA-ARDS groups. Comparison of NEG and MA-ARDS resulted in a significant difference in lung size (p=0.05). When non-MA-ARDScompared with NEG groups, it showed a significant difference in lung width (p=0.001). However, there was no significant difference in lung weight and length (p>0.05). Spearman correlation test showed that there was a strong correlation between parasitemia with weight (p=0.000), length (p=0.001), and lung width (p=0.017). The findings indicated that parasitemia played a role in the development of MA-ARDS in mice infected with P. berghei ANKA and influenced the size of the lung. ","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84171334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Susilo Budi Pratama, Y. Setyaningsih, Daru Lestyanto
ABSTRACT Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation that does not fully return to normal and is associated with the increased inflammatory response in the airways due to exposure to noxious particles or gases. Workers are susceptible to exposure to steam, dust, gases, and fumes in the work environment. Administration of antioxidants can be beneficial in COPD patients by reducing oxidative stress to reduce the inflammatory response. Ginger contains various active ingredients that act as antioxidants. The research design is a quasi-experimental study with a pre-test and post-test approach. The research subjects were 30 subjects workers diagnosed with COPD. Subjects were divided into two groups: the control group was given standard therapy, the treatment group was given standard therapy and ginger extract. The treatment was given for one month, then the neutrophil and the COPD Assessment Test (CAT) scores were checked. The data were analyzed with an unpaired difference test. The treatment group (-5.67 +2.32) experienced more CAT decline than the control group (-0.73 +1.28) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = <0.001). The treatment group (-4.93 +4.43) experienced more neutrophil decline than the control group (0.27 +1.10) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = < 0.001). Administration of ginger extract can reduce neutrophil levels and CAT scores in COPD workers due to dust exposure. Keywords : COPD, CAT score, neutrophil, gingerCorrespondence : susilobudipratama@gmail.com
{"title":"The effect of ginger (Zingiber officinale) extract on the neutrophil level and CAT (COPD Assessment Test) scores in workers with COPD due to dust exposure","authors":"Susilo Budi Pratama, Y. Setyaningsih, Daru Lestyanto","doi":"10.30651/jqm.v6i1.9711","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.9711","url":null,"abstract":"ABSTRACT Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation that does not fully return to normal and is associated with the increased inflammatory response in the airways due to exposure to noxious particles or gases. Workers are susceptible to exposure to steam, dust, gases, and fumes in the work environment. Administration of antioxidants can be beneficial in COPD patients by reducing oxidative stress to reduce the inflammatory response. Ginger contains various active ingredients that act as antioxidants. The research design is a quasi-experimental study with a pre-test and post-test approach. The research subjects were 30 subjects workers diagnosed with COPD. Subjects were divided into two groups: the control group was given standard therapy, the treatment group was given standard therapy and ginger extract. The treatment was given for one month, then the neutrophil and the COPD Assessment Test (CAT) scores were checked. The data were analyzed with an unpaired difference test. The treatment group (-5.67 +2.32) experienced more CAT decline than the control group (-0.73 +1.28) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = <0.001). The treatment group (-4.93 +4.43) experienced more neutrophil decline than the control group (0.27 +1.10) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = < 0.001). Administration of ginger extract can reduce neutrophil levels and CAT scores in COPD workers due to dust exposure. Keywords : COPD, CAT score, neutrophil, gingerCorrespondence : susilobudipratama@gmail.com ","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"96 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91141584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Meida, Ahmad Ikliluddin, Yunani Setyandriana, Ilma Naafisa Anthrasita
ABSTRACT Glaucoma is a disease marked with damage to the optic nerve, chronic and can cause blindness. Glaucoma needs regular therapy to prevent blindness. This study was an observational study using a case-control approach. Data were analyzed using the Mann-Whitney test to determine the differences in blood sugar levels in the DM and non-DM groups and the Chi-Square test to determine differences in the success of glaucoma therapy in DM and non-DM patients. There were 66 samples of glaucoma patients in this study, consisting of 14 men (21.2%) and 52 women (78.8%). The mean age of the patients was 61.12 ± 9.17 years. The sample was divided into 2 groups, namely 34 DM patients (51.5%) and 32 non DM patients (48.5%). The Mann-Whitney test showed significant differences in blood sugar levels between the DM and non-DM groups (p <0.05). Blood sugar levels in the DM group were 202.59 ± 73.5 mg / dL and in the non-DM group was 106.19 ± 16.3 mg / dL. In conclusion, there is no difference in the success of glaucoma therapy in DM and non-DM patients. Keywords : glaucoma, glaucoma therapy, diabetes mellitusCorrespondence :nurshani_meida@yahoo.com
{"title":"The success of glaucoma therapy in diabetes mellitus and non-diabetes mellitus","authors":"N. Meida, Ahmad Ikliluddin, Yunani Setyandriana, Ilma Naafisa Anthrasita","doi":"10.30651/jqm.v6i1.7665","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.7665","url":null,"abstract":"ABSTRACT Glaucoma is a disease marked with damage to the optic nerve, chronic and can cause blindness. Glaucoma needs regular therapy to prevent blindness. This study was an observational study using a case-control approach. Data were analyzed using the Mann-Whitney test to determine the differences in blood sugar levels in the DM and non-DM groups and the Chi-Square test to determine differences in the success of glaucoma therapy in DM and non-DM patients. There were 66 samples of glaucoma patients in this study, consisting of 14 men (21.2%) and 52 women (78.8%). The mean age of the patients was 61.12 ± 9.17 years. The sample was divided into 2 groups, namely 34 DM patients (51.5%) and 32 non DM patients (48.5%). The Mann-Whitney test showed significant differences in blood sugar levels between the DM and non-DM groups (p <0.05). Blood sugar levels in the DM group were 202.59 ± 73.5 mg / dL and in the non-DM group was 106.19 ± 16.3 mg / dL. In conclusion, there is no difference in the success of glaucoma therapy in DM and non-DM patients. Keywords : glaucoma, glaucoma therapy, diabetes mellitusCorrespondence :nurshani_meida@yahoo.com","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75562668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic kidney disease patients commonly present in a clinical setting with hypertension may cause or affect the disease. Carvedilol, a beta-blocker that is routinely used to treat hypertension in chronic kidney disease, was proven to be safer compared to other beta-blockers. However, it may still cause AV nodal block. AV nodal block can cause bradyarrhythmia, resulting in low cardiac output and low blood supply to multiple organs, including the kidney. This condition further impaired the kidney function in regulating potassium levels and cause hyperkalemia. Hyperkalemia, in return, can also cause bradycardia, and the vicious cycle goes on and on. Previous studies reported that calcium gluconate administration might significantly improve the patient’s condition. However, in this case, calcium gluconate failed to give significant improvement even though it reduced the potassium level. We report a 53 years old male patient on carvedilol with bradyarrhythmia, chronic kidney disease, shock, and hyperkalemia (BRASH syndrome) that failed to resolve with calcium gluconate administration.
{"title":"Bradycardia, renal failure, shock, and hyperkalemia (BRASH) caused by AV nodal blocker: a case report of a patient with BRASH syndrome resistant to calcium administration","authors":"Sidhi Laksono, A. S. Prawara","doi":"10.30651/jqm.v6i1.6248","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.6248","url":null,"abstract":"Chronic kidney disease patients commonly present in a clinical setting with hypertension may cause or affect the disease. Carvedilol, a beta-blocker that is routinely used to treat hypertension in chronic kidney disease, was proven to be safer compared to other beta-blockers. However, it may still cause AV nodal block. AV nodal block can cause bradyarrhythmia, resulting in low cardiac output and low blood supply to multiple organs, including the kidney. This condition further impaired the kidney function in regulating potassium levels and cause hyperkalemia. Hyperkalemia, in return, can also cause bradycardia, and the vicious cycle goes on and on. Previous studies reported that calcium gluconate administration might significantly improve the patient’s condition. However, in this case, calcium gluconate failed to give significant improvement even though it reduced the potassium level. We report a 53 years old male patient on carvedilol with bradyarrhythmia, chronic kidney disease, shock, and hyperkalemia (BRASH syndrome) that failed to resolve with calcium gluconate administration.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86351729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract A clavicle fracture is one of the most common bone injuries occurring in 2-5% of all adult fractures. Clavicle fractures rarely require surgery. Most of the cases were treated by conservative methods. Conservative treatment yields satisfactory results. However, some latest studies showed an incidence of nonunion of up to 15% and patient dissatisfaction of 31%. This study analyzed the outcome and incidence of complications between operative therapy compared to conservative treatment. This research design was a retrospective descriptive observative. The study population was all patients diagnosed with clavicle fracture of the middle third in RSUD Dr. Soetomo Surabaya from 2015 to 2019. The total sample was 153 patients, with 95 patients who underwent conservative measures and 58 patients who underwent surgery. From the results, there were significant differences between the mean SF-36 score [90.81 and 98.21 (p = 0.000)], the mean DASH score [6.94 and 2.42 (p = 0.000)] in patients with fractures clavicle middle third treated with conservative and operative treatment. The union and functional rates were also better in the operative group. This study shows that the operative treatment on clavicle fractures is superior compared to conservative therapy. Keywords: Clavicle fracture, operative treatment, DASH score, SF-36 scoreCorrespondence: dr.harisdwi@gmail.com
{"title":"Comparison of subjective and functional results on the operative and non-operative application of clavicle fractures","authors":"Haris Dwi Khoirur Rofiq, Erwin Ramawan","doi":"10.30651/jqm.v6i1.7543","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.7543","url":null,"abstract":"Abstract A clavicle fracture is one of the most common bone injuries occurring in 2-5% of all adult fractures. Clavicle fractures rarely require surgery. Most of the cases were treated by conservative methods. Conservative treatment yields satisfactory results. However, some latest studies showed an incidence of nonunion of up to 15% and patient dissatisfaction of 31%. This study analyzed the outcome and incidence of complications between operative therapy compared to conservative treatment. This research design was a retrospective descriptive observative. The study population was all patients diagnosed with clavicle fracture of the middle third in RSUD Dr. Soetomo Surabaya from 2015 to 2019. The total sample was 153 patients, with 95 patients who underwent conservative measures and 58 patients who underwent surgery. From the results, there were significant differences between the mean SF-36 score [90.81 and 98.21 (p = 0.000)], the mean DASH score [6.94 and 2.42 (p = 0.000)] in patients with fractures clavicle middle third treated with conservative and operative treatment. The union and functional rates were also better in the operative group. This study shows that the operative treatment on clavicle fractures is superior compared to conservative therapy. Keywords: Clavicle fracture, operative treatment, DASH score, SF-36 scoreCorrespondence: dr.harisdwi@gmail.com","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"2014 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87756167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahifa Audy Rahima, R. Dewi, Nindya Shinta Rumastika, Dina Helianti
ABSTRACTDiazinon has a hepatotoxic effect since it is metabolized in the liver involving Kupffer cells (KCs) activation, increasing reactive oxygen species (ROS). The flavonoids contained in shallot (Allium cepa L.) skin act as antioxidants neutralizing oxidative stress. This study aims to determine the effect of shallot skin ethanol extract (SSEE) on liver MDA level and activated KCs histopathology. The total flavonoids level of SSEE was measured using the aluminum chloride colorimetric method and resulted in 228.1 mg QE/g. Rats were divided into normal, diazinon, and SSEE groups. Diazinon was administered at a dose of 40 mg/kg b.w. for 7 days, followed by SSEE at the dose of 600, 900, and 1,200 mg/kg b.w. for 7 days. Liver malondialdehyde (MDA) level was measured using the MDA-TBA method. The results revealed that diazinon increased liver MDA level (p <0.05), while SSEE at doses of 900 and 1,200 mg/kg b.w. decreased liver MDA level equal to normal (p>0.05). Activated KCs in the SSEE group at a dose of 1,200 mg/kg b.w. was impressively equal to the normal group. In conclusion, SSEE at dose of 1,200 mg/kg b.w. neutralize liver oxidative stress due to diazinon indicated by the decrease of liver MDA level and activated KCs equal to normal.Keywords: antioxidant, diazinon, Kupffer cell, liver, MDA, shallotCorrespondence: rosita.fk@unej.ac.id
{"title":"Shallot (Allium cepa L.) Skin Ethanol Extract Neutralizes Liver Oxidative Stress in Diazinon-Induced Wistar Rats","authors":"Shahifa Audy Rahima, R. Dewi, Nindya Shinta Rumastika, Dina Helianti","doi":"10.30651/jqm.v6i1.8038","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.8038","url":null,"abstract":"ABSTRACTDiazinon has a hepatotoxic effect since it is metabolized in the liver involving Kupffer cells (KCs) activation, increasing reactive oxygen species (ROS). The flavonoids contained in shallot (Allium cepa L.) skin act as antioxidants neutralizing oxidative stress. This study aims to determine the effect of shallot skin ethanol extract (SSEE) on liver MDA level and activated KCs histopathology. The total flavonoids level of SSEE was measured using the aluminum chloride colorimetric method and resulted in 228.1 mg QE/g. Rats were divided into normal, diazinon, and SSEE groups. Diazinon was administered at a dose of 40 mg/kg b.w. for 7 days, followed by SSEE at the dose of 600, 900, and 1,200 mg/kg b.w. for 7 days. Liver malondialdehyde (MDA) level was measured using the MDA-TBA method. The results revealed that diazinon increased liver MDA level (p <0.05), while SSEE at doses of 900 and 1,200 mg/kg b.w. decreased liver MDA level equal to normal (p>0.05). Activated KCs in the SSEE group at a dose of 1,200 mg/kg b.w. was impressively equal to the normal group. In conclusion, SSEE at dose of 1,200 mg/kg b.w. neutralize liver oxidative stress due to diazinon indicated by the decrease of liver MDA level and activated KCs equal to normal.Keywords: antioxidant, diazinon, Kupffer cell, liver, MDA, shallotCorrespondence: rosita.fk@unej.ac.id","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78100224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeremi Setiawan, Hanna Cakrawati, Anung Putri Illahika
ABSTRACT Health problems that are often encountered due to work are respiratory disorders that cause premature death every year. Exposure to pollution is harmful to health, and chronic exposure causes lung cancer and COPD. The use of masks is an alternative in reducing exposure to pollution. This study aimed to determine the relationship between the habit of wearing masks on the incidence of respiratory symptoms disorder of online motorcycle taxi drivers in Malang. This study was an analytic observation with a cross-sectional design. Samples were determined using the comparative bivariate analytical sample formula. The data were analyzed using a univariate test and bivariate analysis with a chi-square test. This study showed a significant relationship between the habit of wearing a mask with p score = 0.015 (p<0,05), changing time with p score = 0.004 (p<0,05), and the type of mask on respiratory symptoms disorders with p score = 0.006 (p<0,05). The results obtained regarding the description of the habit of using masks, the results of the method of using masks were mainly in the good category. In conclusion, there is a significant relationship between the habit of wearing masks and the incidence of respiratory symptoms disorders among online motorcycle taxi drivers in Malang. Keywords : Habits, masks, symptoms of respiratory disorders, online motorcycle taxisCorrespondence : Jeremisetiawan@webmail.umm.ac.id
{"title":"Analysis of the relationship between using personal protective equipment (PPE) masks on the incidence of respiratory symptoms disorders of online motorcycle taxis drivers in Malang","authors":"Jeremi Setiawan, Hanna Cakrawati, Anung Putri Illahika","doi":"10.30651/jqm.v6i1.10267","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.10267","url":null,"abstract":"ABSTRACT Health problems that are often encountered due to work are respiratory disorders that cause premature death every year. Exposure to pollution is harmful to health, and chronic exposure causes lung cancer and COPD. The use of masks is an alternative in reducing exposure to pollution. This study aimed to determine the relationship between the habit of wearing masks on the incidence of respiratory symptoms disorder of online motorcycle taxi drivers in Malang. This study was an analytic observation with a cross-sectional design. Samples were determined using the comparative bivariate analytical sample formula. The data were analyzed using a univariate test and bivariate analysis with a chi-square test. This study showed a significant relationship between the habit of wearing a mask with p score = 0.015 (p<0,05), changing time with p score = 0.004 (p<0,05), and the type of mask on respiratory symptoms disorders with p score = 0.006 (p<0,05). The results obtained regarding the description of the habit of using masks, the results of the method of using masks were mainly in the good category. In conclusion, there is a significant relationship between the habit of wearing masks and the incidence of respiratory symptoms disorders among online motorcycle taxi drivers in Malang. Keywords : Habits, masks, symptoms of respiratory disorders, online motorcycle taxisCorrespondence : Jeremisetiawan@webmail.umm.ac.id","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"75 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85768679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. A. Mahdi, P. Z. Romadhon, U. Y. Bintoro, Merlyna Savitri, P. N. Amrita, M. N. Diansyah, Ami Ashariati Prayoga, Kartika Prahasanti
Extranodal non-Hodgkin lymphoma still seems to be a rare case and an issue to discuss a lot. Clinical evidence and guidelines on treatment have not yet been widely published and accessible. We present a case of a forty-five-year-old male with the chief complaint of a bulky and huge right mass in the testis with an ulcer on it. The patient underwent an orchiectomy, and the biopsy showed a malignant round cell tumor, suspected as non-Hodgkin lymphoma. The patient then received the following treatment: chemotherapy with R-CHOP regiment every three weeks, consisting of 6 cycles showing shrinkage size of the testis by day 7 and final complete response after 4th cycle with ADE grade 0 no sexual activity disorder after chemotherapy. This raises hope in developing treatment modalities that the right choice on chemotherapy regimen with complete control on the drug effects may improve clinical outcome and patient’s quality of life.
{"title":"Management and quality of life extranodal non hodgkin lymphoma of testis","authors":"B. A. Mahdi, P. Z. Romadhon, U. Y. Bintoro, Merlyna Savitri, P. N. Amrita, M. N. Diansyah, Ami Ashariati Prayoga, Kartika Prahasanti","doi":"10.30651/jqm.v6i1.7610","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.7610","url":null,"abstract":"Extranodal non-Hodgkin lymphoma still seems to be a rare case and an issue to discuss a lot. Clinical evidence and guidelines on treatment have not yet been widely published and accessible. We present a case of a forty-five-year-old male with the chief complaint of a bulky and huge right mass in the testis with an ulcer on it. The patient underwent an orchiectomy, and the biopsy showed a malignant round cell tumor, suspected as non-Hodgkin lymphoma. The patient then received the following treatment: chemotherapy with R-CHOP regiment every three weeks, consisting of 6 cycles showing shrinkage size of the testis by day 7 and final complete response after 4th cycle with ADE grade 0 no sexual activity disorder after chemotherapy. This raises hope in developing treatment modalities that the right choice on chemotherapy regimen with complete control on the drug effects may improve clinical outcome and patient’s quality of life.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83973177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iswandi Darwis, Gusti Ngurah P Pradnya Wisnu, S. Mentari
ABSTRACT Around 25% of people with diabetes experience diabetic foot ulcers in their lives, accompanied by infections due to various types of bacteria. Infection due to Gram-negative and Gram-positive bacteria are reported to have different inflammation patterns, where the latter being reported to have a higher mortality rate. This study was an analytic observational study with a cross-sectional design to determine the relationship between bacterial characteristics and mortality in diabetic foot ulcers. Data were obtained from medical records of diabetic ulcer patients admitted to Dr. H. Abdul Moeloek General Hospital, Lampung, in 2017–2020. There were 131 diabetic foot ulcers patients identified, with the median age of the subjects was 53 years, 43.5% of the subject were male, and 56.5% were female. The mean hemoglobin was 9.3 g/dl, WBCs were 19.0 ×103/ml, and platelets were 422.1 ×103/ml. The mean length of stay in the hospital was 10.7 days. Eighteen subjects died during the hospital stay, with 15 of them were from the Gram-negative monomicrobial group. The results of the Fischer Exact test on mortality and bacterial characteristics among monomicrobial infections (p=0.688) indicate no relationship between the characteristics of the infectious pathogen and mortality in diabetic foot ulcers. Keywords: bacteria, diabetes, diabetic foot ulcers, mortalityCorrespondence: iswandi.darwis@gmail.com
大约25%的糖尿病患者在其生活中经历过糖尿病足溃疡，并伴有各种细菌感染。据报道，由革兰氏阴性菌和革兰氏阳性菌引起的感染具有不同的炎症模式，后者据报道具有较高的死亡率。本研究是一项分析性观察性研究，采用横断面设计来确定糖尿病足溃疡中细菌特征与死亡率之间的关系。数据来自2017-2020年楠榜H. Abdul Moeloek综合医院收治的糖尿病溃疡患者的医疗记录。共发现131例糖尿病足溃疡患者，年龄中位数为53岁，男性占43.5%，女性占56.5%。平均血红蛋白9.3 g/dl，白细胞19.0 ×103/ml，血小板422.1 ×103/ml。平均住院时间为10.7天。住院期间死亡18例，其中革兰氏阴性单菌组死亡15例。单微生物感染致死率和细菌特征的Fischer精确检验结果(p=0.688)表明，糖尿病足溃疡的感染性病原体特征与致死率之间没有关系。关键词:细菌，糖尿病，糖尿病足溃疡，死亡率对应:iswandi.darwis@gmail.com
{"title":"The relationship between bacterial characteristics and mortality in diabetic foot ulcers' patients admitted to Dr. H. Abdul Moeloek General Hospital, Lampung","authors":"Iswandi Darwis, Gusti Ngurah P Pradnya Wisnu, S. Mentari","doi":"10.30651/jqm.v6i1.7501","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.7501","url":null,"abstract":"ABSTRACT Around 25% of people with diabetes experience diabetic foot ulcers in their lives, accompanied by infections due to various types of bacteria. Infection due to Gram-negative and Gram-positive bacteria are reported to have different inflammation patterns, where the latter being reported to have a higher mortality rate. This study was an analytic observational study with a cross-sectional design to determine the relationship between bacterial characteristics and mortality in diabetic foot ulcers. Data were obtained from medical records of diabetic ulcer patients admitted to Dr. H. Abdul Moeloek General Hospital, Lampung, in 2017–2020. There were 131 diabetic foot ulcers patients identified, with the median age of the subjects was 53 years, 43.5% of the subject were male, and 56.5% were female. The mean hemoglobin was 9.3 g/dl, WBCs were 19.0 ×103/ml, and platelets were 422.1 ×103/ml. The mean length of stay in the hospital was 10.7 days. Eighteen subjects died during the hospital stay, with 15 of them were from the Gram-negative monomicrobial group. The results of the Fischer Exact test on mortality and bacterial characteristics among monomicrobial infections (p=0.688) indicate no relationship between the characteristics of the infectious pathogen and mortality in diabetic foot ulcers. Keywords: bacteria, diabetes, diabetic foot ulcers, mortalityCorrespondence: iswandi.darwis@gmail.com","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81601918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Prasetya, K. Nanda, Khofifah Dwi Oktaviana, Lens Hanin Herda Zhafirah, Lia Lisa Arista, M. D. Dermawan
ABSTRACT COVID-19 (Coronavirus Disease 2019) is still a significant problem; therefore, mental health issues and COVID-19 are starting to get attention because of the increasing psychological impact and mainly because of Substance Use Disorder (SUD). Further study is required on this issue. This paper aimed to determine the prevalence, diagnosis, and treatment of SUD during the COVID-19 pandemic. This literature review is gained from scientific articles with a range of publication years from 2016 to 2021 about SUD During the COVID-19 pandemic based on Prevalence, Diagnosis, and psychotherapy of the published journal using Pubmed, Google Scholar, and SAGE Journals, and then critically reviewed. The prevalence of SUD patients during the COVID-19 pandemic has increased; however, digital psychotherapy strategies for SUD patients have been found and proved effective during the pandemic. In conclusion, the COVID-19 pandemic impacts a person's mental and behavior and could be a high-risk opportunity for substance abuse. Therefore health workers must improve health services for SUD patients to receive the health access needed even in a pandemic.Keywords: Mental Health, Substance Use Disorder, COVID-19, Prevalence, Diagnosis, ManagementCorrespondence : dedydermawan555@gmail.com
{"title":"Mental and behavioral disorders due to substances during the COVID-19 Pandemic: Prevalence, diagnosis, and management","authors":"E. Prasetya, K. Nanda, Khofifah Dwi Oktaviana, Lens Hanin Herda Zhafirah, Lia Lisa Arista, M. D. Dermawan","doi":"10.30651/jqm.v6i1.10444","DOIUrl":"https://doi.org/10.30651/jqm.v6i1.10444","url":null,"abstract":"ABSTRACT COVID-19 (Coronavirus Disease 2019) is still a significant problem; therefore, mental health issues and COVID-19 are starting to get attention because of the increasing psychological impact and mainly because of Substance Use Disorder (SUD). Further study is required on this issue. This paper aimed to determine the prevalence, diagnosis, and treatment of SUD during the COVID-19 pandemic. This literature review is gained from scientific articles with a range of publication years from 2016 to 2021 about SUD During the COVID-19 pandemic based on Prevalence, Diagnosis, and psychotherapy of the published journal using Pubmed, Google Scholar, and SAGE Journals, and then critically reviewed. The prevalence of SUD patients during the COVID-19 pandemic has increased; however, digital psychotherapy strategies for SUD patients have been found and proved effective during the pandemic. In conclusion, the COVID-19 pandemic impacts a person's mental and behavior and could be a high-risk opportunity for substance abuse. Therefore health workers must improve health services for SUD patients to receive the health access needed even in a pandemic.Keywords: Mental Health, Substance Use Disorder, COVID-19, Prevalence, Diagnosis, ManagementCorrespondence : dedydermawan555@gmail.com","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86909926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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