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Using a Target Product Profile (TPP) to guide innovation for future In Vitro Diagnostic (IVD) developments in the United States 使用目标产品概要(TPP)来指导美国未来体外诊断(IVD)发展的创新
Q2 Social Sciences Pub Date : 2023-08-12 DOI: 10.1080/23779497.2023.2244561
Ricky Soong, E. Bradford, Kenneth B Yeh, G. Olinger
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引用次数: 0
Conflict and social determinants of health: would global health diplomacy resolve the Afghanistan healthcare conundrum? 冲突与健康的社会决定因素:全球卫生外交能否解决阿富汗的卫生保健难题?
Q2 Social Sciences Pub Date : 2023-06-21 DOI: 10.1080/23779497.2023.2223601
Bawa Singh, Sandeep Singh, J. Kaur, Kulwinder Singh, Abdul Wasi Popalzay
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引用次数: 0
Working beyond health: roles of global health security agenda, experiences of Thailand’s chairmanship amidst of the uncertainty of the COVID-19 pandemic 超越卫生领域的工作:全球卫生安全议程的作用,在2019冠状病毒病大流行的不确定性中泰国担任主席国的经验
Q2 Social Sciences Pub Date : 2023-05-28 DOI: 10.1080/23779497.2023.2213752
S. Hinjoy, Royce Tsukayama, Jintana Sriwongsa, D. Kingnate, S. Damrongwatanapokin, Wattana Masunglong, Pitchapa Kleeblumjeak, Walaiporn Jiaranairungroj, K. Limpakarnjanarat, Sura Wisedsak
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引用次数: 0
Public Health Emergency of International Concern declared by the World Health Organization for Monkeypox 世界卫生组织宣布猴痘为国际关注的突发公共卫生事件
Q2 Social Sciences Pub Date : 2022-09-16 DOI: 10.1080/23779497.2022.2124185
R. Sah, B. Padhi, Abdelmonem Siddiq, A. Abdelaal, A. Reda, Basant Ismail Lashin, A. Mohanty, Najim Z. Alshahrani, A. Rodríguez-Morales
ABSTRACT Monkeypox (MPX) was a rare endemic disease in western and central Africa. In 1970, the first detected case of human MPX was reported in the Democratic Republic of Congo, and it was detected outside Africa in 2003. Currently, there are about 31,799 confirmed MPX cases which led the WHO to declare the disease a public health emergency of international concern which is considered the seventh deceleration by the WHO between 2009 and 2022. Herein, we aim to review the history behind the outbreak of the disease, its mode of transmission, and the target of WHO deceleration, while providing recommendations for disease prevention. The disease is prevalent mostly in the United States with a total case number of 10,676 which is considered a high-risk country. Meanwhile, other countries are at moderate risk. The disease can be transmitted directly through contact with different body fluids, infectious lesions, or sexual activity. We conclude that there should be high public awareness to stop the transmission of the disease. In addition, there is a great need to follow the instructions provided by public health institutions since vaccines, till now, are available only for high-risk populations secondary to their shortage.
猴痘(MPX)是西非和中非一种罕见的地方病。1970年,在刚果民主共和国报告了第一例发现的人类MPX病例,2003年在非洲以外发现了该病例。目前,确诊的MPX病例约为31799例,世界卫生组织因此宣布该疾病为国际关注的突发公共卫生事件,这被世界卫生组织认为是2009年至2022年期间的第七次减速。在此,我们旨在回顾该疾病爆发背后的历史,其传播方式和世卫组织减速目标,同时为疾病预防提供建议。这种疾病主要在美国流行,总病例数为10676,被认为是高风险国家。与此同时,其他国家的风险适中。这种疾病可以通过接触不同的体液、传染性病变或性行为直接传播。我们的结论是,应该提高公众的意识来阻止这种疾病的传播。此外,非常需要遵循公共卫生机构提供的指示,因为到目前为止,疫苗只提供给高危人群,其次是疫苗短缺。
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引用次数: 14
A link between radicalisation models and extremist propaganda 激进化模式和极端主义宣传之间的联系
Q2 Social Sciences Pub Date : 2022-07-27 DOI: 10.1080/23779497.2022.2103446
Kyle A. Msall, Noor Lary
ABSTRACT This study explores the relationship between extremist propaganda and the process of radicalisation. Two theories of the radicalisation process are explored which include a linear approach and a non-linear approach. The Dabiq magazines published by ISIS were analysed qualitatively to understand the possible link between propaganda and radicalising future ISIS fighters. The findings found that the Dabiq magazines were in line with Sageman’s radicalisation process which is non-linear. All of the magazine issues contained various aspects that fit into the four stages of Sageman’s model which suggests that ISIS is attempting to radicalise future enlistments by using multiple methods within the Dabiq issues.
摘要本研究探讨极端主义宣传与激进化过程之间的关系。探索激进化过程的两种理论,包括线性方法和非线性方法。对ISIS出版的Dabiq杂志进行了定性分析,以了解宣传与未来ISIS战士的激进化之间可能存在的联系。研究发现,Dabiq杂志与Sageman的激进化过程是一致的,这是非线性的。所有的杂志问题都包含了符合Sageman模型的四个阶段的各个方面,这表明ISIS试图通过在Dabiq问题中使用多种方法来激进化未来的入伍。
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引用次数: 1
Biotechnology and Biodefense Enterprise: An Industry Perspective on Defence Acquisition 生物技术和生物防御企业:国防采办的工业视角
Q2 Social Sciences Pub Date : 2022-07-27 DOI: 10.1080/23779497.2022.2102527
Kenneth B Yeh, Eric Du, G. Olinger, Donna S. Boston
ABSTRACT Biotechnology is gaining priority along with other rapidly evolving disciplines in science and engineering due to its potential for innovating the modern military. The broad nature of biotechnology is directly relevant to the military and defence sector where the applications span clinical diagnostics, medical countermeasures and therapeutics, to environmental remediation and biofuels for energy. Although the process for a commercial biotech research and development (R&D) pipeline and the Department of Defence (DOD) acquisition cycle both aim to result in products, they follow two distinctly different pathways. In the biotech industry, the pipeline progresses from basic to applied science that includes design and R&D, commercialisation and product launch, where market forces and financial returns on investment drive priorities. Along the way, the scientific and iterative nature of R&D often results in several candidates for a given assay, drug, therapeutic or vaccine, many of which are unsuccessful or wind up in the so-called valley of death. The DOD acquisition process is a multi-phase and often multi-decade cradle-to-grave product lifecycle engrained in mission requirements, warfighter needs and creating legacy programmes of record. The biotech industry is composed of many small R&D and ‘big pharma’ companies that meet DOD’s unique medical mission requirements. These small R&D companies considered that non-traditional DOD acquisition partners are developing new innovations in biotechnology, but the complex DOD acquisition process is challenging for these small start-ups to navigate. Technology solutions that gain support through DOD acquisitions are able to successfully develop their products and bridge the valley of death by obtaining much needed funding for advanced development, test and evaluation, and demonstration through clinical trials. Our analysis profiles three case histories involving private-public partnerships that yielded biotech products developed through the DOD acquisition cycle that continues to meet current and future medical mission requirements.
由于生物技术具有创新现代军事的潜力,它与其他快速发展的科学和工程学科一起获得了优先考虑。生物技术的广泛性质与军事和国防部门直接相关,其应用范围涵盖临床诊断、医疗对策和治疗、环境修复和能源生物燃料。尽管商业生物技术研发(R&D)流程和国防部(DOD)采购周期都旨在产生产品,但它们遵循两种截然不同的途径。在生物技术行业,从基础科学发展到应用科学,包括设计和研发、商业化和产品发布,其中市场力量和投资的财务回报决定了优先事项。在这一过程中,研发的科学性和迭代性往往会导致一种特定的检测方法、药物、治疗方法或疫苗有几个候选方案,其中许多都不成功,或者最终进入所谓的死亡之谷。国防部采购过程是一个多阶段的过程,通常是几十年的产品生命周期,根植于任务需求、作战人员需求和创建传统记录项目中。生物技术产业由许多小型研发和“大型制药”公司组成,这些公司满足国防部独特的医疗任务要求。这些小型研发公司认为,非传统的国防部采办合作伙伴正在开发生物技术方面的新创新,但复杂的国防部采办过程对这些小型初创企业来说是一个挑战。通过国防部收购获得支持的技术解决方案能够成功开发其产品,并通过获得急需的资金来进行先进的开发、测试和评估,并通过临床试验进行演示,从而跨越死亡之谷。我们的分析概述了三个案例历史,这些案例涉及公私合作伙伴关系,通过国防部采购周期开发生物技术产品,继续满足当前和未来的医疗任务需求。
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引用次数: 2
Hazardous material and chemical, biological, radiological, and nuclear incident readiness among prehospital care professionals in the State of Qatar 卡塔尔国院前护理专业人员对危险物质和化学、生物、放射性和核事件的准备情况
Q2 Social Sciences Pub Date : 2022-05-05 DOI: 10.1080/23779497.2022.2069142
Hassan Farhat, J. Laughton, P. Gangaram, Kawther El Aifa, Mohamed Chaker Khenissi, Ouissem Zaghouani, M. Khadhraoui, I. Gargouri, Guillaume Alinier
ABSTRACT This study aimed to determine whether the Hamad Medical Corporation Ambulance Service (HMCAS) personnel fulfil the pre-hospital readiness requirements for hazardous material and chemical, biological, radiological, and nuclear (HazMat-CBRN) incidents. This cross-sectional study performed an online assessment of non-specialist paramedics’ behaviour and knowledge about HazMat-CBRN incident management, followed by a ‘HazMat-CBRN incident management’ course with pre-and post-activity assessments. The validity and reliability of the knowledge assessment questions were also tested. The pre-and-post course assessement responses revealed certain deficiencies in staff knowledge. The multiple linear regression and paired groups t-test demonstrated that this was rectified after the training intervention. The results indicate that the implemented course helped HMCAS staff acquire a satisfactory level of knowledge to ensure their readiness for safe and effective responses to potential HazMat-CBRN incidents in Qatar.
本研究旨在确定哈马德医疗救护服务(HMCAS)人员是否满足危险物质和化学、生物、放射和核(HazMat-CBRN)事件的院前准备要求。这项横断面研究对非专业护理人员的行为和关于HazMat-CBRN事件管理的知识进行了在线评估,随后进行了“HazMat-CBRN事件管理”课程,并进行了活动前和活动后评估。对知识评估题的效度和信度进行了检验。课程前后的评价反映出工作人员知识方面的某些不足。多元线性回归和配对组t检验表明,这种情况在训练干预后得到了纠正。结果表明,实施的课程帮助HMCAS工作人员获得了令人满意的知识水平,以确保他们准备好安全有效地应对卡塔尔潜在的危害物质- cbrn事件。
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引用次数: 5
Stability, security, and the social determinants of health 稳定、安全和健康的社会决定因素
Q2 Social Sciences Pub Date : 2022-03-15 DOI: 10.1080/23779497.2022.2047092
Diana Aguirre, Casey Perez, Edwin K Burkett
ABSTRACT Social determinants of health are an important aspect of improving health outcomes. Militaries have deployed global health engagement activities to meet security objectives from peacetime through post-conflict. Two frameworks, the Social Model of Health and the U.S. Institute of Peace Strategic Framework for Stabilisation and Reconstruction, have similarities and are reviewed in this paper. Drawing similarities between the two presents opportunities for targeted, well-planned global health engagement activities that may bring stronger health outcomes. Military global health efforts must work with civil affairs experts and civilian partners within the host nation health context to target the most amenable social determinants of health elements that may enhance security and stability in that society.
健康的社会决定因素是改善健康结果的一个重要方面。军队部署了全球卫生参与活动,以实现从和平时期到冲突后的安全目标。卫生社会模式和美国和平研究所稳定与重建战略框架这两个框架具有相似之处,本文对此进行了回顾。两者之间的相似之处为有针对性、计划周密的全球卫生参与活动提供了机会,这些活动可能带来更强有力的卫生成果。军事全球卫生工作必须与东道国卫生领域的民事专家和民事伙伴合作,以可能加强该社会安全和稳定的卫生要素中最容易接受的社会决定因素为目标。
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引用次数: 0
Investing to kill: return on investment of tobacco companies compared to high-mortality and neutral industries 投资杀人:烟草公司与高死亡率和中性行业相比的投资回报
Q2 Social Sciences Pub Date : 2022-03-13 DOI: 10.1080/23779497.2022.2038035
M. R. Hollman, J. Pearce
ABSTRACT Terrorists have worked directly with tobacco companies and used tobacco sales to fund traditional terrorist activities. This familiarity with tobacco, coupled with the high mortality rate of tobacco indicates terrorists may use tobacco investing as a means of covert legal killings (CLK), which refers to the terrorist intention of mass killing in a targeted group using legal means. To provide insight into tobacco investors’ motives this study 1) quantifies annual death rate for leading mortality-causing industries in America.; 2) identifies eight companies responsible for the highest CLK; 3) compares investment returns for eight high-mortality companies to the S&P 500 from 2009 to 2019 to determine if tobacco is the most likely target for terrorist-based CLK. The top three highest mortality rate companies and thus best CLK investments from a terrorist perspective were tobacco companies: Altria Group Inc., Reynolds America Inc., and Imperial Brands. Together, these tobacco companies are responsible for >436,800 American premature deaths/year, yet tobacco investments performed worse than the S&P500 over the last decade. It is clear that for CLK investors, tobacco is the most efficient means of investing to kill Americans. Questionable tobacco investor intentionality, combined with the recent advancement in CLK theory makes it reasonable to assume that some tobacco investors are terrorists using their wealth to specifically target and kill Americans. To determine how widespread this practice is, future work is needed to evaluate CLK tobacco investors against the Terrorist Screening Database.
恐怖分子直接与烟草公司合作,利用烟草销售来资助传统的恐怖活动。这种对烟草的熟悉,再加上烟草的高死亡率,表明恐怖分子可能利用烟草投资作为秘密合法杀戮(CLK)的手段,这是指恐怖分子意图利用合法手段对目标群体进行大规模杀戮。为了深入了解烟草投资者的动机,本研究1)量化了美国主要致死行业的年死亡率;2)确定8家负责最高CLK的公司;3)将2009年至2019年8家高死亡率公司的投资回报与标准普尔500指数进行比较,以确定烟草是否是以恐怖主义为基础的CLK最有可能的目标。从恐怖分子的角度来看,死亡率最高的前三家公司,因此也是最好的CLK投资是烟草公司:奥驰亚集团、雷诺美国公司和帝国品牌。这些烟草公司加在一起,每年造成美国436,800人过早死亡,但在过去十年中,烟草投资的表现不如标准普尔500指数。很明显,对于CLK投资者来说,烟草是杀死美国人的最有效的投资手段。可疑的烟草投资者的意图,加上最近CLK理论的进展,使我们有理由假设一些烟草投资者是恐怖分子,利用他们的财富专门针对和杀害美国人。为了确定这种做法有多普遍,需要未来的工作来评估CLK烟草投资者与恐怖分子筛选数据库的关系。
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引用次数: 1
Bacterial contamination of healthcare worker’s mobile phones: a case study at two referral hospitals in Uganda 卫生保健工作者手机的细菌污染:乌干达两家转诊医院的案例研究
Q2 Social Sciences Pub Date : 2022-01-24 DOI: 10.1080/23779497.2021.2023321
Fred Tusabe, Maureen Kesande, A. Amir, Olivia Iannone, R. Ayebare, J. Nanyondo
ABSTRACT Hospital and community-acquired infections are escalating and pose significant public health unhealthiness worldwide. The advancements of telemedicine and automation of healthcare records are supported by cellphones, laptops and wearable devices. This study focused on the incidence of healthcare workers’ mobile phones becoming contaminated with pathogenic bacteria and their possible roles as vehicles of transmission of antimicrobial-resistant bacteria. A case study at two referral hospitals in Uganda between May and October 2020. Self-administered questionnaires were administered to participants after informed consent. Mobile phones of the participants in different departments of the hospitals were swabbed and samples were collected and transported to the microbiology laboratory for bacterial culture and antimicrobial susceptibility tests. The point prevalence of Healthcare workers’ mobile phone bacterial contamination with one or more species was 93%. Organisms isolated were E. coli 5.6% (1), Micrococcus spp 11.1% (2), Coagulase-negative staphylococci, CoNS, 61.1% (11) and Bacillus spp 22.2% (4). About 45% of the organisms were multidrug-resistant. Resistance was major to penicillin, cotrimoxazole, ciprofloxacin and Gentamicin, respectively. The isolated E. coli was resistant to all antibiotics used in the study. Only 15% (2) of the participants disinfected their phones at least once a week and 8% cleaned their hands after using a mobile phone. Healthcare Workers’ mobile phones can act as fomites for the transmission of multidrug-resistant microorganisms. This study provides strong evidence for developing and strengthening disinfection protocols for mobile phones and does not underscore the importance of hand hygiene in the middle of a patient encounter especially when the HCW grabs a phone but doesn’t re-clean their hands before patient contact. Abbreviations: MDR, Multidrug-resistant; WHO, World Health Organization; IPC, infection prevention and control; HHC, hand hygiene compliance; JMEDICC, Joint Mobile Emerging Disease Intervention Clinical Capability
医院和社区获得性感染正在升级,并在全球范围内造成重大的公共卫生不健康。远程医疗和医疗记录自动化的进步得到了手机、笔记本电脑和可穿戴设备的支持。本研究的重点是卫生保健工作者的手机被致病菌污染的发生率,以及它们作为抗微生物耐药细菌传播媒介的可能作用。2020年5月至10月在乌干达两家转诊医院进行的案例研究。在知情同意后对参与者进行自我管理的问卷调查。在医院不同科室的参与者的手机上擦拭,收集样本并运送到微生物实验室进行细菌培养和抗菌药敏试验。医务人员手机细菌污染一种或多种的点患病率为93%。分离出的细菌分别为大肠杆菌5.6%(1株)、微球菌11.1%(2株)、凝固酶阴性葡萄球菌con 61.1%(11株)和芽孢杆菌22.2%(4株)。耐药主要为青霉素、复方新诺明、环丙沙星和庆大霉素。分离出的大肠杆菌对研究中使用的所有抗生素都具有耐药性。只有15%(2)的参与者每周至少对手机消毒一次,8%的人在使用手机后洗手。医护人员的移动电话可能成为多重耐药微生物传播的媒介。这项研究为制定和加强手机消毒方案提供了强有力的证据,并没有强调在病人接触过程中手卫生的重要性,特别是当医护人员拿起手机但在接触病人之前没有重新洗手时。缩写:MDR,耐多药;世卫组织,世界卫生组织;感染预防和控制;HHC,手部卫生合规;联合流动新发疾病干预临床能力
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引用次数: 1
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Global Security Health Science and Policy
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