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Efficacy of transcranial direct current stimulation on tension-type headache and migraine: A systematic review 经颅直流电刺激治疗紧张型头痛和偏头痛的疗效:系统综述
Pub Date : 2022-09-01 DOI: 10.4103/ijpn.ijpn_24_22
Gupta Saloni, G. Deepak, M. Preeti, Garg Shobit, Singhal Tushar
Introduction: Headache is one of the most common conditions troubling nearly 68% of the world's population. Tension-type headache (TTH) & migraine are the most common forms of classical headaches, which is nowadays mostly neglected, associated with frequent, severe pain and significant functional impairment. Transcranial direct current stimulation (tDCS), is a non-invasive, painless brain stimulation treatment that uses direct electrical currents to stimulate specific parts of the brain. Various studies demonstrated tDCS as a valued device to treat neuropsychiatric conditions such as chronic headache & associated anxiodepressive condition. Objective: The aim of this the current review was to evaluate the effectiveness of tDCS in the management of TTH and Migraine. Results generated from various studies for the effectiveness of tDCS in TTH & Migraine. Methods: We programmed our search strategy, to identify studies pertaining to use of tDCS and pain management in TTH & migraine, within the Database of the Cochrane Library of Systematic Reviews, & various author manuscripts in PMC, MEDLINE, EMBASE, NLM, PsycINFO, Other indexed citations from inception to December 2021 and potentially relevant studies. Outcomes: The outcomes of interest include: Effective pain management, in terms of headache intensity, frequency, its episodes, associated depression, anxiety, in target population prioritised by the individual reviews. The evidences were mapped and synthesised with appropriate health problem, patient subgroups, intervention type, context and outcome.Conclusions: We found a significant reduction of pain intensity in patients receiving tDCS treatment, also the pain intensity and duration were significantly improved from baseline after tDCS treatment and during a follow-up period. There was a significant reduction of pain intensity by both anodal and cathodal stimulation conditions, with noteworthy decrease in episodic headaches equally by both 1mA and 2mA current intensities. The aforementioned works support the utility of tDCS in the pain management of TTH and migraine offering a hope for patients with this debilitating disease. However, the review shows promising results in the pain management by tDCS, but the included studies must be analysed critically since most of them were pilot studies, with some having adapted an open-label design.
引言:头痛是困扰全球近68%人口的最常见疾病之一。紧张型头痛(TTH)和偏头痛是最常见的典型头痛形式,目前大多被忽视,与频繁、剧烈的疼痛和严重的功能损伤有关。经颅直流电刺激(tDCS)是一种无创、无痛的大脑刺激治疗方法,使用直流电刺激大脑的特定部位。各种研究表明,tDCS是治疗神经精神疾病的一种有价值的设备,如慢性头痛和相关的焦虑抑郁症。目的:本综述旨在评估tDCS在TTH和偏头痛治疗中的有效性。tDCS对TTH和偏头痛有效性的各种研究结果。方法:我们对我们的搜索策略进行了编程,以在Cochrane系统评价图书馆的数据库中确定与tDCS和TTH和偏头痛疼痛管理相关的研究,以及PMC、MEDLINE、EMBASE、NLM、PsycINFO中的各种作者手稿,以及从开始到2021年12月的其他索引引文和潜在的相关研究。结果:感兴趣的结果包括:在个人评估优先考虑的目标人群中,有效的疼痛管理,包括头痛强度、频率、发作次数、相关抑郁、焦虑。将证据与适当的健康问题、患者亚组、干预类型、背景和结果进行映射和综合。结论:我们发现接受tDCS治疗的患者的疼痛强度显著降低,并且在tDCS治疗后和随访期间,疼痛强度和持续时间也比基线显著改善。阳极和阴极刺激条件下的疼痛强度显著降低,1mA和2mA电流强度下的发作性头痛显著降低。上述工作支持tDCS在TTH和偏头痛疼痛管理中的应用,为这种使人衰弱的疾病的患者提供了希望。然而,该综述显示,tDCS在疼痛管理方面取得了有希望的结果,但必须对纳入的研究进行批判性分析,因为其中大多数是试点研究,有些研究采用了开放标签设计。
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引用次数: 0
Preemptive analgesia with wound infiltration using bupivacaine with dexmedetomidine and bupivacaine alone for postoperative analgesia in abdominal hysterectomy: A prospective randomized analytical study 布比卡因联合右美托咪定和单独布比卡因用于腹式子宫切除术术后预防性伤口浸润镇痛:一项前瞻性随机分析研究
Pub Date : 2022-09-01 DOI: 10.4103/ijpn.ijpn_47_22
Priyanka Shelwatkar, Sujit Kshirsagar, P. Bhalerao
Background: The administration of local anesthetics into the wound before the incision (preemptive analgesia) has been demonstrated to reduce postoperative pain. Aims: The aim of this study was to determine the quality of postoperative analgesia in abdominal hysterectomy by visual analog scale (VAS) in the group of 0.125% bupivacaine 15 ml with dexmedetomidine 1 μg/kg and in the group of 0.125% bupivacaine 15 ml alone. Settings and Design: A prospective observational analytical study was conducted in a tertiary care government hospital including 80 patients undergoing hysterectomy divided into two groups of 40 each. Subjects and Methods: Group A included those patients who received 0.125% bupivacaine 15 ml with dexmedetomidine 1 μg/kg and Group B patients received bupivacaine 15 ml alone. The pain was assessed by VAS. Rescue analgesia was given with diclofenac sodium 75 mg intramuscular on demand or whenever the VAS score was ≥4. The level of sedation was assessed using the four-point Sedation Scale. Nausea and vomiting were assessed by four-point categorical scales. Statistical Analysis: Mean and standard deviation were used to depict quantitative data, and paired t-test was used to compare the groups. Results: The combination of bupivacaine with dexmedetomidine has a better and longer anesthetic effect than bupivacaine alone (P < 0.001). The total diclofenac consumption in Group A was less (95.63 [±33.92] mg) than in Group B (150 [±0.0] mg), P < 0.01. Group A rescue analgesia was required after 2 h in only one (2.5%) patient, whereas in Group B, rescue analgesia was required immediately at 0 h in six (15%) patients (P < 0.001). Conclusions: The duration of analgesia was longer, and number of doses of rescue analgesia during the first 24 h after operation was significantly less in the group who received bupivacaine with dexmedetomidine when compared with bupivacaine alone.
背景:在切口前将局麻药注入伤口(先发制人的镇痛)已被证明可以减少术后疼痛。目的:采用视觉模拟评分法(VAS)评价0.125%布比卡因15 ml联合右美托咪定1 μg/kg组和0.125%布比卡因15 ml单用组腹部子宫切除术术后镇痛质量。背景与设计:在一家三级政府医院进行了一项前瞻性观察性分析研究,将80例子宫切除术患者分为两组,每组40例。对象与方法:A组患者采用0.125%布比卡因15 ml联合右美托咪定1 μg/kg, B组患者单独使用布比卡因15 ml。采用VAS评估疼痛程度。根据需要或VAS评分≥4分时给予双氯芬酸钠75 mg肌内镇痛。采用镇静四级评分法评估镇静水平。恶心和呕吐用4分分类量表进行评估。统计分析:定量资料采用均数和标准差描述,组间比较采用配对t检验。结果:布比卡因与右美托咪定合用麻醉效果优于布比卡因单用麻醉效果(P < 0.001)。A组患者双氯芬酸总用量(95.63[±33.92]mg)低于B组(150[±0.0]mg), P < 0.01。A组只有1例(2.5%)患者需要在2 h后立即镇痛,而B组有6例(15%)患者在0 h后立即镇痛(P < 0.001)。结论:与单用布比卡因组相比,布比卡因联合右美托咪定组镇痛持续时间更长,术后前24 h抢救镇痛剂量明显减少。
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引用次数: 0
The myth and half-truths of fetal pain decrypted: A metaverse 胎儿疼痛的神话和半真半假解密:一个超宇宙
Pub Date : 2022-09-01 DOI: 10.4103/ijpn.ijpn_5_22
Sargam Goel, Sumana Choudhary, A. Saxena, Mayank Sonkar
Fetal pain is one of the most controversial topics in medicine because of the disagreement between people whether the fetus can perceive pain or not and the absence of any direct objective method for the assessment of fetal pain. Although fetus is incapable of declaring pain, various studies have shown that the mere experience of pain without the aptitude of self-contemplation is worth paying attention to, and that the pain in fetus need not be comparable to that of a mature adult to matter. Furthermore, refusing to acknowledge fetal pain in late preterm fetuses would jeopardize the advances in neonatal care because it would question the use of analgesia in neonates of similar gestational age. This systematic review article examines the neuroanatomical and physiological evidence of nociception in the fetus and its implications, which compel the need for its alleviation. It looks into the adequacy of International Association for the Study of Pain definition of pain to define fetal pain. The article also provides a brief overview of the existing literature on whether safe analgesia and anesthesia techniques exist for abortions and therapeutic fetal procedures. We performed a literature search for English-language articles using the electronic database with keywords: controversy in fetal pain, fetal anaesthesia, fetal analgesia, fetal pain, fetus, neuroanatomy of fetal pain, neurophysiology of fetal pain, nociception, and recent advances in understanding of fetal pain
胎儿疼痛是医学上最具争议的话题之一,因为人们对胎儿是否能感知疼痛存在分歧,而且缺乏任何直接客观的方法来评估胎儿疼痛。尽管胎儿无法宣布疼痛,但各种研究表明,仅仅是疼痛的经历而没有自我思考的能力是值得关注的,胎儿的疼痛不必与成熟成年人的疼痛相提并论。此外,拒绝承认晚期早产胎儿的胎儿疼痛将危及新生儿护理的进展,因为这将质疑在类似胎龄的新生儿中使用镇痛。这篇系统综述文章探讨了胎儿伤害感受的神经解剖学和生理学证据及其影响,这些证据迫使人们需要减轻伤害。它探讨了国际疼痛研究协会对疼痛的定义是否足以定义胎儿疼痛。文章还简要概述了关于堕胎和胎儿治疗程序是否存在安全镇痛和麻醉技术的现有文献。我们使用电子数据库对英文文章进行了文献检索,关键词为:胎儿疼痛争议、胎儿麻醉、胎儿镇痛、胎儿疼痛、胎儿、胎儿疼痛神经解剖学、胎儿疼痛的神经生理学、伤害感受和对胎儿疼痛理解的最新进展
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引用次数: 0
Effect of adjunctive transcranial direct current stimulation and cognitive behavior therapy on headache disability in episodic frequent or chronic tension-type headache: A pilot, exploratory study 辅助经颅直流电刺激和认知行为治疗对发作性频繁或慢性紧张性头痛患者头痛功能障碍的影响:一项初步探索性研究
Pub Date : 2022-09-01 DOI: 10.4103/ijpn.ijpn_52_22
Saloni Gupta, D. Goel, Shobit Garg, S. Tikka, Preeti Mishra, Priya Tyagi
Background: Literature suggests that non-pharmacological treatments like non-invasive brain stimulation and cognitive behavioural therapy (CBT) may be used as augments in the management of Tension-Type Headache (TTH). Aims and Objectives: To assess the efficacy of Transcranial Direct Current Stimulation (tDCS) and Cognitive Behavioral Therapy (CBT) compared to treatment as usual (TAU) on headache-related disability and the psychological impact of headache on life of patients suffering from TTH. Materials and Methods: Thirty right-handed TTH patients HDI (headache disability index) > 30 were randomly allocated to group A (tDCS + TAU), group B (CBT + TAU), and group C (TAU). While the primary outcome measure was headache related disability (Headache Disability Index(HDI)), somatic symptoms (Somatic Symptom Severity (SSS-8)), anxiety & depression (Hospital Anxiety and Depression Scale (HADS)) and sleep quality (Pittsburgh Sleep Quality Index (PSQI). Assessments were done at baseline, end of the third and sixth month. Results: We found a statistically significant reduction in HDI (F=12.419, p <0.001), SSS-8 (F=4.587, p=0.010), and HADS-anxiety (F=4.810, p=0.002). tDCS showed better efficacy than CBT, while these two were significantly better than TAU on HDI and SSS-8. On HADS-A also both tDCS and CBT were better than TAU, but showed no significant difference between them. Conclusion: Supplementing non-pharmacological techniques like tDCS and CBT will be effective in reducing headache-related disability and associated psychological symptoms.
背景:文献表明,非药物治疗如非侵入性脑刺激和认知行为疗法(CBT)可以作为管理紧张性头痛(TTH)的补充。目的和目的:比较经颅直流电刺激(tDCS)和认知行为疗法(CBT)与常规治疗(TAU)对TTH患者头痛相关残疾的疗效以及头痛对患者生活的心理影响。材料与方法:将30例右利手TTH患者HDI(头痛失能指数)bbb30随机分为A组(tDCS + TAU)、B组(CBT + TAU)和C组(TAU)。而主要结局指标是头痛相关残疾(头痛残疾指数(HDI))、躯体症状(躯体症状严重程度(SSS-8))、焦虑和抑郁(医院焦虑和抑郁量表(HADS))和睡眠质量(匹兹堡睡眠质量指数(PSQI))。评估在基线、第三个月和第六个月结束时进行。结果:我们发现HDI (F=12.419, p <0.001)、SSS-8 (F=4.587, p=0.010)和hads -焦虑(F=4.810, p=0.002)有统计学意义的降低。tDCS对HDI和SSS-8的疗效优于CBT,两者均显著优于TAU。在HADS-A方面,tDCS和CBT均优于TAU,但两者之间无显著差异。结论:辅以tDCS和CBT等非药物治疗可有效减轻头痛相关残疾及相关心理症状。
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引用次数: 1
A novel approach to vagus nerve stimulation in fibromyalgia 纤维肌痛患者迷走神经刺激的新方法
Pub Date : 2022-09-01 DOI: 10.4103/ijpn.ijpn_77_22
C. Aragón-Benedí, A. Rocha-Romero, M. Fajardo-Pérez, Carmen Heredia-Coca
This manuscript aims to report the successful treatment of a patient with fibromyalgia using a novel approach to vagus nerve (VN) stimulation. The patient reported significant pain relief and improved performance after almost 3 months of follow-up. VN stimulation has been Food and Drug Administration approved for epilepsy and depression, but recent studies have shown its usefulness for pain management. Our novel approach is minimally-invasive compared to surgical techniques; it provides long-lasting analgesia within a single session and is cheaper than current methods. This technique should be evaluated in clinical trials to clarify the optimal parameters and treatment intervals.
本文旨在报告使用迷走神经(VN)刺激的新方法成功治疗纤维肌痛患者。经过近3个月的随访,患者报告疼痛明显减轻,表现改善。VN刺激已被美国食品药品监督管理局批准用于治疗癫痫和抑郁症,但最近的研究表明它对疼痛管理有用。与外科技术相比,我们的新方法是微创的;它在一次疗程内提供持久的镇痛,并且比目前的方法便宜。该技术应在临床试验中进行评估,以明确最佳参数和治疗间隔。
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引用次数: 0
A rotator cuff injury affecting the prognosis of a patient with myofascial pain 肩袖损伤对肌筋膜疼痛患者预后的影响
Pub Date : 2022-09-01 DOI: 10.4103/ijpn.ijpn_51_22
S. Naz, S. Sibha
Shoulder pathology occurs most commonly in food service workers, who repetitively perform motions of the upper limbs. About 85% of patients who visit pain clinics complain of nonarticular musculoskeletal impairments. Myofascial pain syndrome is one of the common, painful musculoskeletal disorders characterized by the presence of trigger points in muscles at discrete places. Here is a case presenting with symptoms of myofascial pain of the upper trapezius; on clinical examination, ultrasonographic findings were diagnosed with a rotator cuff injury delaying her recovery. This also highlights the importance of clinical examination of ipsilateral shoulder joint whenever the patient presents with myofascial pain involving upper back.
肩部病变最常见于餐饮服务人员,他们反复进行上肢运动。在疼痛诊所就诊的患者中,约85%的人抱怨非关节肌肉骨骼损伤。肌筋膜疼痛综合征是一种常见的疼痛性肌肉骨骼疾病,其特征是肌肉中离散位置存在触发点。这是一个表现为上斜方肌筋膜疼痛症状的病例;在临床检查中,超声检查结果被诊断为肩袖损伤,延误了她的康复。这也突出了当患者出现涉及上背部的肌筋膜疼痛时,对同侧肩关节进行临床检查的重要性。
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引用次数: 0
A case report on botox for neurogenic thoracic outlet syndrome – An alternative to surgery 肉毒杆菌毒素治疗神经性胸廓出口综合征的病例报告-替代手术
Pub Date : 2022-09-01 DOI: 10.4103/ijpn.ijpn_88_21
M. Chandra, Sudheer Dara, R. Varma
Thoracic outlet syndrome (TOS) remains one of the underdiagnosed conditions due to the unavailability of specific tests. The pain of TOS may mimic shoulder pain and or cervical radicular pain. Understanding the pathology and type of TOS is the key to successful management. Although surgery remains the final permanent solution in a conformed case of TOS, conservative therapies do provide great relief from pain. Botox remains one of the modalities in managing TOS pain by relieving the spasm of the scalene group of muscles and thereby alleviating the compression symptoms.
胸廓出口综合征(TOS)仍然是诊断不足的疾病之一,因为无法进行特定的测试。TOS的疼痛可能类似于肩部疼痛和/或颈神经根疼痛。了解TOS的病理学和类型是成功管理的关键。尽管手术仍然是TOS的最终永久解决方案,但保守治疗确实能极大地缓解疼痛。肉毒杆菌毒素仍然是通过缓解斜角肌群痉挛从而缓解压迫症状来治疗TOS疼痛的方式之一。
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引用次数: 0
Ideal radiocontrast pattern during celiac plexus alcohol neurolysis 乳糜丛酒精神经松解术的理想放射线造影剂
Pub Date : 2022-09-01 DOI: 10.4103/ijpn.ijpn_91_22
A. Chakravarty
{"title":"Ideal radiocontrast pattern during celiac plexus alcohol neurolysis","authors":"A. Chakravarty","doi":"10.4103/ijpn.ijpn_91_22","DOIUrl":"https://doi.org/10.4103/ijpn.ijpn_91_22","url":null,"abstract":"","PeriodicalId":32328,"journal":{"name":"Indian Journal of Pain","volume":"36 1","pages":"168 - 168"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48540259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From the desk of new editor-in-chief 来自新任主编的办公桌
Pub Date : 2022-05-01 DOI: 10.4103/ijpn.ijpn_75_22
Samarjit Dey
{"title":"From the desk of new editor-in-chief","authors":"Samarjit Dey","doi":"10.4103/ijpn.ijpn_75_22","DOIUrl":"https://doi.org/10.4103/ijpn.ijpn_75_22","url":null,"abstract":"","PeriodicalId":32328,"journal":{"name":"Indian Journal of Pain","volume":"36 1","pages":"69 - 69"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42594441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Block: Component of a multimodal approach to taming the stress response in pheochromocytoma resection 阻滞:在嗜铬细胞瘤切除术中控制应激反应的多模式方法的组成部分
Pub Date : 2022-05-01 DOI: 10.4103/ijpn.ijpn_98_21
Bhavna Hooda, Shalendra Singh, D. Dwivedi, R. Goyal
{"title":"Block: Component of a multimodal approach to taming the stress response in pheochromocytoma resection","authors":"Bhavna Hooda, Shalendra Singh, D. Dwivedi, R. Goyal","doi":"10.4103/ijpn.ijpn_98_21","DOIUrl":"https://doi.org/10.4103/ijpn.ijpn_98_21","url":null,"abstract":"","PeriodicalId":32328,"journal":{"name":"Indian Journal of Pain","volume":"36 1","pages":"114 - 115"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48698229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Indian Journal of Pain
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