Jianwen Jia, Zeping Jin, Mirzat Turhon, Yixin Lin, Xinjian Yang, Yang Wang, Yunpeng Liu
Objectives
There remains a conspicuous absence of systematic analysis concerning the risk factors for the development of ischemic complications in the interventional treatment of IAs. Our study aimed to identify the risk factors for ischemic complications after the interventional treatment of IAs and to make an individualized prediction of the occurrence of ischemic complications, providing important reference guidance for clinicians.
Methods
This study encompassed a sample of 473 patients diagnosed with intracranial aneurysms (IA) and treated at our center between February 2022 and April 2024. Ischemic complications were identified via clinical symptomatology and corroborated with diagnostic subtraction angiography (DSA), computed tomography (CT), or magnetic resonance imaging (MRI). We used a machine learning (ML) approach to screen potential variables for ischemic complications and identify correlations between them, and subsequently constructed a logistic regression model to quantify these correlations.
Results
Patients were categorized based on the occurrence or absence of ischemic complications. A total of five potential factors were screened using LASSO regression, XGBoost, and Randomforest algorithms: hypertension, history of alcohol consumption, multiple IAs, rupture status, and antiplatelet agent. Multivariate analysis further disclosed that hypertension, history of alcohol consumption, ruptured aneurysms, and antiplatelet agent were independent risk factors for postoperative ischemic complications. The predictive model, derived from the multivariate regression analysis results, demonstrated robust reliability.
Conclusions
Hypertension, history of alcohol consumption, ruptured aneurysms, and antiplatelet agent as independent risk factors for ischemic complications following the interventional treatment of IAs. Accordingly, we constructed the first risk prediction model regarding ischemic complications of all IAs based on these factors, aiming to enhance prognostic judgment and treatment strategy planning.
{"title":"Risk Factors and Predictive Model for Ischemic Complications in Endovascular Treatment of Intracranial Aneurysms: Insights From a Large Patient Cohort","authors":"Jianwen Jia, Zeping Jin, Mirzat Turhon, Yixin Lin, Xinjian Yang, Yang Wang, Yunpeng Liu","doi":"10.1002/agm2.70021","DOIUrl":"https://doi.org/10.1002/agm2.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>There remains a conspicuous absence of systematic analysis concerning the risk factors for the development of ischemic complications in the interventional treatment of IAs. Our study aimed to identify the risk factors for ischemic complications after the interventional treatment of IAs and to make an individualized prediction of the occurrence of ischemic complications, providing important reference guidance for clinicians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study encompassed a sample of 473 patients diagnosed with intracranial aneurysms (IA) and treated at our center between February 2022 and April 2024. Ischemic complications were identified via clinical symptomatology and corroborated with diagnostic subtraction angiography (DSA), computed tomography (CT), or magnetic resonance imaging (MRI). We used a machine learning (ML) approach to screen potential variables for ischemic complications and identify correlations between them, and subsequently constructed a logistic regression model to quantify these correlations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients were categorized based on the occurrence or absence of ischemic complications. A total of five potential factors were screened using LASSO regression, XGBoost, and Randomforest algorithms: hypertension, history of alcohol consumption, multiple IAs, rupture status, and antiplatelet agent. Multivariate analysis further disclosed that hypertension, history of alcohol consumption, ruptured aneurysms, and antiplatelet agent were independent risk factors for postoperative ischemic complications. The predictive model, derived from the multivariate regression analysis results, demonstrated robust reliability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Hypertension, history of alcohol consumption, ruptured aneurysms, and antiplatelet agent as independent risk factors for ischemic complications following the interventional treatment of IAs. Accordingly, we constructed the first risk prediction model regarding ischemic complications of all IAs based on these factors, aiming to enhance prognostic judgment and treatment strategy planning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"126-136"},"PeriodicalIF":2.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p>The world is experiencing rapid aging according to a report from the United Nations. The demography will shift drastically as the fertility rate falls and people are living longer. In 2021, one in 10 people globally were aged 65 or above. In 2050, this age group is projected to rise to one in six people worldwide [<span>1</span>].</p><p>This demographic shift increases the demand for hospitalization and emergency department (ED) services [<span>2</span>]. In the United States, the older population accounts for over 20% of annual ED visits [<span>3</span>]. This also means an increase in the complexity of acute care cases, with older patients experiencing more geriatric syndromes such as delirium, cognitive impairment, and falls [<span>4</span>]. Furthermore, older people visiting EDs often present with multiple comorbidities, polypharmacy, complex physiologic changes, and multifaceted social and physical needs [<span>4</span>]. These demands have put extra stress on the healthcare system.</p><p>To address this growing need, acute outreach services to long-term aged care facilities (or nursing homes) have been developed in recent years to help reduce hospitalizations and ED presentations from older people dwelling in these facilities [<span>5, 6</span>]. In Australia, these services have been found to be safe, accounting for no unexpected deaths and only 5.3% of older patients presenting to hospital for further investigation or treatment [<span>5</span>]. In one Australian study, ED presentation has been reduced by 10%, and during long-term follow-up, the hospitalization rate is reduced by 36% [<span>5, 7</span>]. Moreover, the cost-benefit analysis shows that the ratio is 1:5, meaning that one dollar spent on acute outreach service will save five dollars if a patient is to be hospitalized. However, the caveat is that adherence to safe inclusion and exclusion criteria is essential, and the experience factor plays a paramount role [<span>5, 7</span>].</p><p>During the COVID pandemic, the use of telemedicine has been accelerated, including for nursing home patients. The efficacy and safety of its use for the treatment of acute illnesses other than COVID in the nursing home setting are less clear in the literature. The first paper of its kind revealed that the safety outcome is comparable to face-to-face [<span>8</span>]. Importantly, the condition under which this is carried out needs to be considered, as the study was undertaken by an experienced team and in a single-center urban setting [<span>8</span>]. Furthermore, the use of telemedicine by geriatricians is accompanied by experienced frontline face-to-face nursing staff and is limited to the weekend service. Hence, the generalization to a rural setting, where recruitment of well-trained nursing staff is more difficult, is unclear. The implication will be of immense importance if telemedicine for acute illnesses is found to be equally safe and efficacious in a rural setting compared with an u
根据联合国的一份报告，世界正在经历快速老龄化。随着生育率的下降和人们寿命的延长，人口结构将发生巨大变化。2021年，全球有十分之一的人年龄在65岁或以上。到2050年，这一年龄组预计将上升到全球人口的六分之一。这种人口结构的转变增加了对住院和急诊服务的需求[10]。在美国，老年人口占每年ED就诊人数的20%以上。这也意味着急性护理病例的复杂性增加，老年患者会出现更多的老年综合征，如谵妄、认知障碍和跌倒。此外，访问急诊科的老年人经常出现多种合并症，多种药物，复杂的生理变化，以及多方面的社会和身体需求[10]。这些需求给医疗系统带来了额外的压力。为了满足这一日益增长的需求，近年来发展了长期老年护理设施（或养老院）的急性外展服务，以帮助减少居住在这些设施中的老年人的住院和急诊科表现[5,6]。在澳大利亚，这些服务被认为是安全的，没有意外死亡，只有5.3%的老年患者到医院接受进一步的调查或治疗。在澳大利亚的一项研究中，ED的表现减少了10%，在长期随访中，住院率减少了36%[5,7]。此外，成本效益分析显示，这一比例为1:5，这意味着，如果病人住院，在急性外诊服务上花费1美元将节省5美元。然而，需要注意的是，遵守安全的纳入和排除标准是必不可少的，体验因素起着至关重要的作用[5,7]。在2019冠状病毒病大流行期间，远程医疗的使用加快了，包括对养老院患者的使用。在疗养院环境中使用它治疗COVID以外的急性疾病的有效性和安全性在文献中不太清楚。这类的第一篇论文揭示了安全结果与面对面的bbb相当。重要的是，需要考虑进行这项研究的条件，因为这项研究是由一个经验丰富的团队在单一中心的城市环境中进行的。此外，老年病医生使用远程医疗是由经验丰富的一线面对面护理人员陪同，仅限于周末服务。因此，推广到农村环境，在那里招聘训练有素的护理人员更困难，是不清楚的。如果发现在农村环境中治疗急性病的远程医疗与在城市环境中一样安全有效，因为农村距离较远，而且老年医生等人力资源相对缺乏，使其成为一种有吸引力的创新（如果可行的话），那么这种影响将具有极大的重要性。在老年人居住的养老院治疗体弱多病的老年人有明显的优势。例如，与转移到一个新的医院环境相比，他们生活在一个更熟悉的环境中可能会减少谵妄的发生。更少的转院也可能意味着对医院和急诊科资源的压力更小。然而，也存在挑战。患有多种合并症的老年、体弱患者病情恶化和医疗并发症的风险更高。进一步开展护理点调查也是有益的，特别是在农村地区。这些可能包括即时血液检查、超声波检查和x光检查。在养老院，治疗选择可能有限，因为由于距离因素，一些需要每天多次注射或输液的药物是不可能的。外展服务的经验是无价的，成熟服务的路径可能需要更加谨慎，并修改现有的城市包容和排除标准，以适应当地农村的需要。还有一个额外的技术挑战，Wi-Fi服务可能不能很好地工作，软件和硬件可能不像在城市地区那样容易获得。必须仔细定义将患者纳入这些服务的标准，因为像诊断相关组（DRG）这样的广泛分类可能会忽略患者个体需求的细微差别。例如，接受慢性阻塞性肺疾病（COPD）加重DRG患者的风险可能因个体而异。较严重的病例（氧合不良，呼吸和心率加快）可能不太适合远程医疗或急性外联服务，特别是在风险可能高于城市环境的农村环境中，后者拥有更有经验的工作人员，如果患者病情恶化，更容易转移到医院。 针对老年人口的急性疾病开发远程医疗的旅程仍处于早期阶段，特别是在农村地区。前面有许多挑战，需要精心规划和收集数据来指导我们前进。不应为了效率而牺牲医疗保健的安全和质量。换句话说，真正的效率或疗效应该包括良好的安全性和护理质量。Daniel Kam Yin Chan发表意见，整理并撰写了这篇社论。作者声明无利益冲突。
{"title":"The Development of Acute Outreach Services in Aged Care Facilities (Nursing Homes): Using Telemedicine in Rural Areas","authors":"Daniel Kam Yin Chan","doi":"10.1002/agm2.70013","DOIUrl":"https://doi.org/10.1002/agm2.70013","url":null,"abstract":"<p>The world is experiencing rapid aging according to a report from the United Nations. The demography will shift drastically as the fertility rate falls and people are living longer. In 2021, one in 10 people globally were aged 65 or above. In 2050, this age group is projected to rise to one in six people worldwide [<span>1</span>].</p><p>This demographic shift increases the demand for hospitalization and emergency department (ED) services [<span>2</span>]. In the United States, the older population accounts for over 20% of annual ED visits [<span>3</span>]. This also means an increase in the complexity of acute care cases, with older patients experiencing more geriatric syndromes such as delirium, cognitive impairment, and falls [<span>4</span>]. Furthermore, older people visiting EDs often present with multiple comorbidities, polypharmacy, complex physiologic changes, and multifaceted social and physical needs [<span>4</span>]. These demands have put extra stress on the healthcare system.</p><p>To address this growing need, acute outreach services to long-term aged care facilities (or nursing homes) have been developed in recent years to help reduce hospitalizations and ED presentations from older people dwelling in these facilities [<span>5, 6</span>]. In Australia, these services have been found to be safe, accounting for no unexpected deaths and only 5.3% of older patients presenting to hospital for further investigation or treatment [<span>5</span>]. In one Australian study, ED presentation has been reduced by 10%, and during long-term follow-up, the hospitalization rate is reduced by 36% [<span>5, 7</span>]. Moreover, the cost-benefit analysis shows that the ratio is 1:5, meaning that one dollar spent on acute outreach service will save five dollars if a patient is to be hospitalized. However, the caveat is that adherence to safe inclusion and exclusion criteria is essential, and the experience factor plays a paramount role [<span>5, 7</span>].</p><p>During the COVID pandemic, the use of telemedicine has been accelerated, including for nursing home patients. The efficacy and safety of its use for the treatment of acute illnesses other than COVID in the nursing home setting are less clear in the literature. The first paper of its kind revealed that the safety outcome is comparable to face-to-face [<span>8</span>]. Importantly, the condition under which this is carried out needs to be considered, as the study was undertaken by an experienced team and in a single-center urban setting [<span>8</span>]. Furthermore, the use of telemedicine by geriatricians is accompanied by experienced frontline face-to-face nursing staff and is limited to the weekend service. Hence, the generalization to a rural setting, where recruitment of well-trained nursing staff is more difficult, is unclear. The implication will be of immense importance if telemedicine for acute illnesses is found to be equally safe and efficacious in a rural setting compared with an u","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"89-90"},"PeriodicalIF":2.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vinícius Pierdoná, Patrícia Lavandoski, Rafael Moura Maurmann, Guilherme Antônio Borges, Jose Carlos Merino Mombach, Fátima Theresinha Costa Rodrigues Guma, Florencia María Barbé-Tuana
Purpose
Premature cellular senescence is a pivotal process in aging and age-related diseases, triggered by various stressors. However, this is not a homogeneous phenotype, but a heterogeneous cellular state composed of multiple senescence programs with different compositions. Therefore, understanding the complex dynamics of senescence programs requires a systemic approach. We introduce PseudoCell, a multivalued logical regulatory network designed to explore the molecular intricacies of premature senescence.
Methods
PseudoCell integrates key senescence signaling pathways and molecular mechanisms, offering a versatile platform for investigating diverse premature senescence programs initiated by different stimuli.
Results
Validation through simulation of classical senescence programs, including oxidative stress-induced senescence and oncogene-induced senescence, demonstrates its ability to replicate molecular signatures consistent with empirical data. Additionally, we explore the role of CCL11, a novel senescence-associated molecule, through simulations that reveal potential pathways and mechanisms underlying CCL11-mediated senescence induction.
Conclusions
In conclusion, PseudoCell provides a systematic approach to dissecting premature senescence programs and uncovering novel regulatory mechanisms.
{"title":"PseudoCell: A Multivalued Logical Regulatory Network to Investigate Premature Senescence Dynamics and Heterogeneity","authors":"Vinícius Pierdoná, Patrícia Lavandoski, Rafael Moura Maurmann, Guilherme Antônio Borges, Jose Carlos Merino Mombach, Fátima Theresinha Costa Rodrigues Guma, Florencia María Barbé-Tuana","doi":"10.1002/agm2.70020","DOIUrl":"https://doi.org/10.1002/agm2.70020","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Premature cellular senescence is a pivotal process in aging and age-related diseases, triggered by various stressors. However, this is not a homogeneous phenotype, but a heterogeneous cellular state composed of multiple senescence programs with different compositions. Therefore, understanding the complex dynamics of senescence programs requires a systemic approach. We introduce PseudoCell, a multivalued logical regulatory network designed to explore the molecular intricacies of premature senescence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PseudoCell integrates key senescence signaling pathways and molecular mechanisms, offering a versatile platform for investigating diverse premature senescence programs initiated by different stimuli.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Validation through simulation of classical senescence programs, including oxidative stress-induced senescence and oncogene-induced senescence, demonstrates its ability to replicate molecular signatures consistent with empirical data. Additionally, we explore the role of CCL11, a novel senescence-associated molecule, through simulations that reveal potential pathways and mechanisms underlying CCL11-mediated senescence induction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In conclusion, PseudoCell provides a systematic approach to dissecting premature senescence programs and uncovering novel regulatory mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"145-155"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiyuan Zhang, Xue Yang, Nina An, Meng Lv, Lanyu Yang, Rui Liu, Song Hu, Weiguo Chen, Wenjing Feng, Yongjun Mao
Objectives
Sarcopenia as an age-related syndrome is marked by a progressive loss of muscle strength and mass or reduced physical function. It is insidious in onset and presents a high prevalence. This study aimed to explore risk factors for sarcopenia in the elderly population and construct predictive models.
Methods
Patients (n = 335) aged 60–93 years and received an examination by a dual-energy X-ray absorptiometry (DXA) or a body composition analyzer (InBody) between January 2020 and May 2024 were included. Clinical data and laboratory test results were collected from these subjects. LASSO and logistic regression models were constructed to identify and evaluate significant risk factors for sarcopenia. A nomogram and a decision tree model were established for the prediction of sarcopenia probability in the elderly. Random forest was employed to rank the importance of variables in predicting sarcopenia.
Results
The potential risk factors for sarcopenia in this study were body mass index, prealbumin, albumin/globulin ratio, serum creatinine, and phosphorus. A nomogram and a decision tree model were constructed based on the factors, showing a high discriminative ability and a high classification accuracy, respectively. Both models were effective in predicting sarcopenia in the elderly, and the nomogram showed a notably reliable predictive performance.
Conclusions
This study identified risk factors and developed predictive models for sarcopenia in older adults, contributing to timely intervention and treatment of the disease. The nomogram provided an intuitive way to measure the probability of sarcopenia in the elderly population, and the decision tree model made the assessment of sarcopenia simple and rapid. Both models are helpful for clinical staff in early screening and identifying sarcopenia.
{"title":"Risk Factors and Predictive Models for Sarcopenia in Older Adults","authors":"Shiyuan Zhang, Xue Yang, Nina An, Meng Lv, Lanyu Yang, Rui Liu, Song Hu, Weiguo Chen, Wenjing Feng, Yongjun Mao","doi":"10.1002/agm2.70012","DOIUrl":"https://doi.org/10.1002/agm2.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Sarcopenia as an age-related syndrome is marked by a progressive loss of muscle strength and mass or reduced physical function. It is insidious in onset and presents a high prevalence. This study aimed to explore risk factors for sarcopenia in the elderly population and construct predictive models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients (<i>n</i> = 335) aged 60–93 years and received an examination by a dual-energy X-ray absorptiometry (DXA) or a body composition analyzer (InBody) between January 2020 and May 2024 were included. Clinical data and laboratory test results were collected from these subjects. LASSO and logistic regression models were constructed to identify and evaluate significant risk factors for sarcopenia. A nomogram and a decision tree model were established for the prediction of sarcopenia probability in the elderly. Random forest was employed to rank the importance of variables in predicting sarcopenia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The potential risk factors for sarcopenia in this study were body mass index, prealbumin, albumin/globulin ratio, serum creatinine, and phosphorus. A nomogram and a decision tree model were constructed based on the factors, showing a high discriminative ability and a high classification accuracy, respectively. Both models were effective in predicting sarcopenia in the elderly, and the nomogram showed a notably reliable predictive performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study identified risk factors and developed predictive models for sarcopenia in older adults, contributing to timely intervention and treatment of the disease. The nomogram provided an intuitive way to measure the probability of sarcopenia in the elderly population, and the decision tree model made the assessment of sarcopenia simple and rapid. Both models are helpful for clinical staff in early screening and identifying sarcopenia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 3","pages":"192-199"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinxin Ma, Fang Liu, Lei Qiu, Juan Chen, Wei Du, Jing He, Aizhen Sheng, Yinhong Liu
Objectives
Cerebral small vascular disease (CSVD) is not rare in neurologically asymptomatic individuals. Glucose control and insulin resistance (IR) may be its risk factors. We aimed to explore the relationship between CSVD markers, glucose control, and IR in neurologically asymptomatic, nondiabetic individuals.
Methods
A total of 412 participants from the annual physical examinations population in our hospital who underwent brain magnetic resonance imaging from May 2019 to June 2021 were enrolled. We collected clinical data and blood test indices and calculated the triglyceride-glucose (TyG) index. CSVD markers were assessed, including lacunes, white matter hyperintensities (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and the total CSVD score. Correlations between CSVD markers, clinical variables, and blood test parameters were analyzed.
Results
The median age of our group was 70.32 ± 10.27 years (45–103 years). The prevalence of asymptomatic CSVD was 43.7%. Lacunes were present in 8.3%, periventricular WMH (PVWMH) in 65.3%, deep WMH (DWMH) in 64.1%, EPVS in 87.4%, and CMBs in 31.3% of individuals. Glycated hemoglobin A1c (HbA1c) varied between PVWMH subgroups (p = 0.043). Fasting blood glucose (FBG) was higher in individuals with deep CMBs than in those without deep CMBs (p = 0.012). FBG was an independent risk factor for deep CMBs after controlling for multiple variables. However, the TyG index was not associated with CSVD markers.
Conclusions
The prevalence of neurologically asymptomatic CSVD is common in the nondiabetic population. It may be beneficial for middle-aged and elderly people to pay attention to their blood glucose levels.
{"title":"Correlation Between Blood Glucose Level and Cerebral Small Vessel Disease Markers in Neurologically Asymptomatic, Nondiabetic Individuals","authors":"Xinxin Ma, Fang Liu, Lei Qiu, Juan Chen, Wei Du, Jing He, Aizhen Sheng, Yinhong Liu","doi":"10.1002/agm2.70017","DOIUrl":"https://doi.org/10.1002/agm2.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Cerebral small vascular disease (CSVD) is not rare in neurologically asymptomatic individuals. Glucose control and insulin resistance (IR) may be its risk factors. We aimed to explore the relationship between CSVD markers, glucose control, and IR in neurologically asymptomatic, nondiabetic individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 412 participants from the annual physical examinations population in our hospital who underwent brain magnetic resonance imaging from May 2019 to June 2021 were enrolled. We collected clinical data and blood test indices and calculated the triglyceride-glucose (TyG) index. CSVD markers were assessed, including lacunes, white matter hyperintensities (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and the total CSVD score. Correlations between CSVD markers, clinical variables, and blood test parameters were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median age of our group was 70.32 ± 10.27 years (45–103 years). The prevalence of asymptomatic CSVD was 43.7%. Lacunes were present in 8.3%, periventricular WMH (PVWMH) in 65.3%, deep WMH (DWMH) in 64.1%, EPVS in 87.4%, and CMBs in 31.3% of individuals. Glycated hemoglobin A1c (HbA1c) varied between PVWMH subgroups (<i>p</i> = 0.043). Fasting blood glucose (FBG) was higher in individuals with deep CMBs than in those without deep CMBs (<i>p</i> = 0.012). FBG was an independent risk factor for deep CMBs after controlling for multiple variables. However, the TyG index was not associated with CSVD markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prevalence of neurologically asymptomatic CSVD is common in the nondiabetic population. It may be beneficial for middle-aged and elderly people to pay attention to their blood glucose levels.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"117-125"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation, oxidative stress, and mitochondrial dysfunction. Recent scientific research underscores that skeletal muscle function is regulated by multiple factors. These include not only physical activity, environmental exposures, and genetic tendencies, but also nutritional deficiencies. Currently, pharmacological interventions for sarcopenia remain a matter of ongoing debate; the recommended strategies for promoting muscle health center on nutritional support therapy and physical exercise. This review offers an insightful examination of the molecular pathways and Pathophysiology contributing to skeletal muscle atrophy and highlights recent progress in employing nonpharmacological approaches (particularly, nutritional supplementation and physical exercise) for its prevention and management. To provide new scientific evidence and effective strategies for the prevention and treatment of sarcopenia, help to bolster the preservation of skeletal muscle function, and improve the quality of life and health of the elderly.
{"title":"Frontiers in Nondrug Treatment of Sarcopenia: A Review of Pathological Mechanisms and the Latest Treatment Strategies","authors":"Qi-Fei Kuang, Yu-Qing Ni, You-Shuo Liu","doi":"10.1002/agm2.70011","DOIUrl":"https://doi.org/10.1002/agm2.70011","url":null,"abstract":"<p>Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation, oxidative stress, and mitochondrial dysfunction. Recent scientific research underscores that skeletal muscle function is regulated by multiple factors. These include not only physical activity, environmental exposures, and genetic tendencies, but also nutritional deficiencies. Currently, pharmacological interventions for sarcopenia remain a matter of ongoing debate; the recommended strategies for promoting muscle health center on nutritional support therapy and physical exercise. This review offers an insightful examination of the molecular pathways and Pathophysiology contributing to skeletal muscle atrophy and highlights recent progress in employing nonpharmacological approaches (particularly, nutritional supplementation and physical exercise) for its prevention and management. To provide new scientific evidence and effective strategies for the prevention and treatment of sarcopenia, help to bolster the preservation of skeletal muscle function, and improve the quality of life and health of the elderly.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 3","pages":"200-209"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gianella Grajeda-León, Victoria Azurin-Gonzales, Zulema Mamani-Condori, Alvaro M. Ñaña-Cordova, Marina A. Bustamante-Ordoñez, Fiorella Neyra-Cordova, José F. Parodi, Fernando M. Runzer Colmenares
Objective
To identify the factors contributing to anxiety among adults aged 65 and older receiving care at the Geriatric Service of the Naval Medical Center.
Methods
An analytical study was conducted through secondary analysis of a database from a study carried out between 2010 and 2015 at the Naval Medical Center of Peru (CEMENA). The data from 1686 participants were analyzed, with anxiety as the dependent variable, measured using the Hamilton Anxiety Rating Scale with a cutoff point of 14. The analysis was performed using STATA software. Bivariate analysis was conducted using the chi-squared and Student t-tests, while Poisson regression was employed for multivariate analysis to determine the frequencies and associations between anxiety and the various variables.
Results
In the multivariate analysis, anxiety was found to be significantly associated with gait speed (PR 1.11; 95% CI 1.03–1.20), depressive symptoms (PR 1.97; 95% CI 1.81–2.16), polypharmacy (PR 1.14; 95% CI 1.04–1.06), and education level (PR 0.83; 95% CI 0.76–0.90). Additionally, marital status was found to be associated with the likelihood of anxiety: being married (PR 0.64; 95% CI 0.53–0.77), widowed (PR 0.54; 95% CI 0.44–0.66), or divorced (PR 0.63; 95% CI 0.49–0.83) were all linked to a lower probability of anxiety compared to being single.
Conclusion
Factors such as depressive symptoms, polypharmacy, slow gait speed, education level, and marital status were found to be associated with anxiety in older adults.
目的探讨海军医疗中心老年服务部65岁及以上老年人焦虑的影响因素。方法通过对秘鲁海军医疗中心（CEMENA） 2010年至2015年开展的一项研究的数据库进行二次分析，进行分析性研究。研究人员分析了1686名参与者的数据，以焦虑为因变量，使用汉密尔顿焦虑评定量表（Hamilton anxiety Rating Scale）进行测量，分界点为14。使用STATA软件进行分析。双变量分析采用卡方检验和学生t检验，多变量分析采用泊松回归，确定焦虑与各变量之间的频率和相关性。结果在多变量分析中，焦虑与步态速度显著相关(PR为1.11；95% CI 1.03-1.20)，抑郁症状(PR 1.97；95% CI 1.81-2.16)，多药(PR 1.14；95% CI 1.04-1.06)，教育程度(PR 0.83；95% ci 0.76-0.90)。此外，婚姻状况被发现与焦虑的可能性有关：已婚(PR = 0.64；95% CI 0.53-0.77)，丧偶(PR 0.54；95% CI 0.44-0.66)或离婚(PR 0.63；95% CI 0.49-0.83)与单身相比，焦虑的可能性都较低。结论抑郁症状、多药、慢步、文化程度、婚姻状况等因素与老年人焦虑有关。
{"title":"Factors Associated With Anxiety Symptoms in Older Adults Attending an Outpatient Geriatric Service: A Cross-Sectional Study","authors":"Gianella Grajeda-León, Victoria Azurin-Gonzales, Zulema Mamani-Condori, Alvaro M. Ñaña-Cordova, Marina A. Bustamante-Ordoñez, Fiorella Neyra-Cordova, José F. Parodi, Fernando M. Runzer Colmenares","doi":"10.1002/agm2.70018","DOIUrl":"https://doi.org/10.1002/agm2.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify the factors contributing to anxiety among adults aged 65 and older receiving care at the Geriatric Service of the Naval Medical Center.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An analytical study was conducted through secondary analysis of a database from a study carried out between 2010 and 2015 at the Naval Medical Center of Peru (CEMENA). The data from 1686 participants were analyzed, with anxiety as the dependent variable, measured using the Hamilton Anxiety Rating Scale with a cutoff point of 14. The analysis was performed using STATA software. Bivariate analysis was conducted using the chi-squared and Student <i>t</i>-tests, while Poisson regression was employed for multivariate analysis to determine the frequencies and associations between anxiety and the various variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the multivariate analysis, anxiety was found to be significantly associated with gait speed (PR 1.11; 95% CI 1.03–1.20), depressive symptoms (PR 1.97; 95% CI 1.81–2.16), polypharmacy (PR 1.14; 95% CI 1.04–1.06), and education level (PR 0.83; 95% CI 0.76–0.90). Additionally, marital status was found to be associated with the likelihood of anxiety: being married (PR 0.64; 95% CI 0.53–0.77), widowed (PR 0.54; 95% CI 0.44–0.66), or divorced (PR 0.63; 95% CI 0.49–0.83) were all linked to a lower probability of anxiety compared to being single.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Factors such as depressive symptoms, polypharmacy, slow gait speed, education level, and marital status were found to be associated with anxiety in older adults.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"99-106"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teguh Santoso, Astrid Feinisa Khairani, Muhammad Hasan Bashari, Julia Ramadhanti, Enny Rohmawati, Monika Pury Oktora, Hesti Lina Wiraswati
Objectives
This research aimed to investigate the potential of Pogostemon cablin Benth's ethanolic extract (PCEE) as an antiaging agent.
Methods
We treated 3T3-L1 cells induced by doxorubicin with PCEE and assessed them with antiaging markers such as GLB-1 gene and telomere length with polymerase chain reaction (PCR), or reactive oxygen species (ROS) accumulation with 2,7-dichlorofluorescein diacetate (DCFHDA).
Results
This study demonstrates that PCEE can inhibit ROS accumulation, decrease the expression level of the senescence-associated β-galactosidase (SA-β-gal) gene, GLB-1, and maintain telomere length in doxorubicin-induced 3T3-L1 cells.
Conclusion
These studies reveal that PCEE is a promising antiaging agent. An in vivo approach should be conducted for further research.
{"title":"Patchouli Ethanol Extract Pogostemon cablin Benth. Against Aging Profiles in Doxorubicin-Induced 3T3-L1 Fibroblast Cell Lines","authors":"Teguh Santoso, Astrid Feinisa Khairani, Muhammad Hasan Bashari, Julia Ramadhanti, Enny Rohmawati, Monika Pury Oktora, Hesti Lina Wiraswati","doi":"10.1002/agm2.70014","DOIUrl":"https://doi.org/10.1002/agm2.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This research aimed to investigate the potential of \u0000 <i>Pogostemon cablin</i>\u0000 Benth's ethanolic extract (PCEE) as an antiaging agent.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We treated 3T3-L1 cells induced by doxorubicin with PCEE and assessed them with antiaging markers such as <i>GLB-1</i> gene and telomere length with polymerase chain reaction (PCR), or reactive oxygen species (ROS) accumulation with 2,7-dichlorofluorescein diacetate (DCFHDA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study demonstrates that PCEE can inhibit ROS accumulation, decrease the expression level of the senescence-associated β-galactosidase (SA-β-gal) <i>gene, GLB-1,</i> and maintain telomere length in doxorubicin-induced 3T3-L1 cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These studies reveal that PCEE is a promising antiaging agent. An in vivo approach should be conducted for further research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"156-163"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linlin Wang, Jun Xu, Xinyu Liu, Feifei Ma, Xingquan Zhao, Anxin Wang, Ruijun Ji, Yongjun Wang, CNSR III investigators
Objectives
To compare the discrimination and calibration of six risk scoring systems in the assessment of patients with stroke-associated pneumonia (SAP) after acute ischemic stroke.
Methods
The validation cohort was derived from the Third China National Stroke Registry. SAP was diagnosed according to the criteria for hospital-acquired pneumonia of the Centers for Disease Control and Prevention. The area under the receiver operating characteristic curve (AUROC) and Hosmer-Lemeshow goodness-of-fit test were used to assess discrimination and calibration.
Results
A total of 12,071 patients were included in the study and 606 (5.02%) patients were diagnosed with in-hospital SAP after ischemic stroke. The AUROC of the six clinical scores ranged from 0.660 to 0.752. In the pairwise comparison, the AIS-APS score (0.752, 95% CI = 0.730–0.773, p < 0.001) showed significantly better discrimination than the other risk models, except the PASS score. The AIS-APS score had the largest Cox and Snell R2 for in-hospital SAP after ischemic stroke. In the subgroup analysis, among patients over 61 years of age, all TOAST subtypes except small vessel disease, length of hospital stay longer than 8 days, male and female sex, different groups stratified by admission NIHSS score and time from onset to arrival, the AIS-APS score showed better discrimination than other risk models with regard to SAP after AIS.
Conclusions
Our study compared the discrimination and calibration of the Kwon Pneumonia Score, A2DS2 score, PANTHERIS score, AIS-APS score, ISAN score, and PASS score in SAP identification; of these, the AIS-APS score showed the best performance.
目的比较6种风险评分系统对急性缺血性脑卒中后卒中相关性肺炎（SAP）患者的区分和校准。方法验证队列来自第三个中国国家卒中登记中心。SAP是根据疾病控制和预防中心的医院获得性肺炎的标准诊断的。采用受试者工作特征曲线下面积（AUROC）和Hosmer-Lemeshow拟合优度检验评估鉴别和校准。结果共纳入12071例患者，其中606例（5.02%）诊断为缺血性脑卒中后住院SAP。6项临床评分的AUROC范围为0.660 ~ 0.752。两两比较，AIS-APS评分（0.752,95% CI = 0.730-0.773, p < 0.001）比除PASS评分外的其他风险模型具有更好的辨别能力。缺血性脑卒中后住院SAP的AIS-APS评分Cox和Snell r2最大。在亚组分析中，在年龄大于61岁、除小血管疾病外所有TOAST亚型、住院时间大于8天、男女、按入院NIHSS评分和发病至到达时间分层的不同组中，AIS- aps评分对AIS后SAP的鉴别性优于其他风险模型。结论本研究比较了Kwon肺炎评分、A2DS2评分、PANTHERIS评分、AIS-APS评分、ISAN评分和PASS评分在SAP鉴定中的鉴别和校准；其中，AIS-APS评分表现最佳。
{"title":"Comparison of Clinical Scores for Predicting Stroke-Associated Pneumonia After Acute Ischemic Stroke","authors":"Linlin Wang, Jun Xu, Xinyu Liu, Feifei Ma, Xingquan Zhao, Anxin Wang, Ruijun Ji, Yongjun Wang, CNSR III investigators","doi":"10.1002/agm2.70003","DOIUrl":"https://doi.org/10.1002/agm2.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare the discrimination and calibration of six risk scoring systems in the assessment of patients with stroke-associated pneumonia (SAP) after acute ischemic stroke.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The validation cohort was derived from the Third China National Stroke Registry. SAP was diagnosed according to the criteria for hospital-acquired pneumonia of the Centers for Disease Control and Prevention. The area under the receiver operating characteristic curve (AUROC) and Hosmer-Lemeshow goodness-of-fit test were used to assess discrimination and calibration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 12,071 patients were included in the study and 606 (5.02%) patients were diagnosed with in-hospital SAP after ischemic stroke. The AUROC of the six clinical scores ranged from 0.660 to 0.752. In the pairwise comparison, the AIS-APS score (0.752, 95% CI = 0.730–0.773, <i>p</i> < 0.001) showed significantly better discrimination than the other risk models, except the PASS score. The AIS-APS score had the largest Cox and Snell <i>R</i>\u0000 <sup>2</sup> for in-hospital SAP after ischemic stroke. In the subgroup analysis, among patients over 61 years of age, all TOAST subtypes except small vessel disease, length of hospital stay longer than 8 days, male and female sex, different groups stratified by admission NIHSS score and time from onset to arrival, the AIS-APS score showed better discrimination than other risk models with regard to SAP after AIS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study compared the discrimination and calibration of the Kwon Pneumonia Score, A2DS2 score, PANTHERIS score, AIS-APS score, ISAN score, and PASS score in SAP identification; of these, the AIS-APS score showed the best performance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"137-144"},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
High-density lipoprotein (HDL), as a crucial component of lipid metabolism, have roles in regulating Alzheimer's disease (AD) core pathology amyloid β (Aβ) and phosphorylated tau (p-tau) through its apolipoproteins, which are associated with brain structures, cognition, and risk of dementia. The pool of HDL apolipoproteins—in the brain and in the periphery—has its own distinct origin, composition, and regulatory mechanisms. It remains unclear whether these apolipoproteins in the periphery and CNS play distinct roles in the pathogenesis of AD. Specifically, this review focus on the distinct associations of apolipoprotein AI and apolipoprotein E—the major components of HDL in the blood and CSF—with pathological proteins, brain integrity, cognition, and dementia progression in AD. We summarize and examine the current state of knowledge on the values of these apolipoproteins in AD pathogenesis and clinical potential.
{"title":"HDL-Apolipoprotein in Alzheimer's Disease Revisited: From Periphery to CNS","authors":"Yihong Huang, Jingyi Tang, Guohua Chen, Qiangqiang Wu, Yongfei Wang, Jianjun Chen, Simei Chen, Jun Liu, Xiaoyun Huang","doi":"10.1002/agm2.70008","DOIUrl":"https://doi.org/10.1002/agm2.70008","url":null,"abstract":"<p>High-density lipoprotein (HDL), as a crucial component of lipid metabolism, have roles in regulating Alzheimer's disease (AD) core pathology amyloid β (Aβ) and phosphorylated tau (p-tau) through its apolipoproteins, which are associated with brain structures, cognition, and risk of dementia. The pool of HDL apolipoproteins—in the brain and in the periphery—has its own distinct origin, composition, and regulatory mechanisms. It remains unclear whether these apolipoproteins in the periphery and CNS play distinct roles in the pathogenesis of AD. Specifically, this review focus on the distinct associations of apolipoprotein AI and apolipoprotein E—the major components of HDL in the blood and CSF—with pathological proteins, brain integrity, cognition, and dementia progression in AD. We summarize and examine the current state of knowledge on the values of these apolipoproteins in AD pathogenesis and clinical potential.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"164-177"},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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