Pub Date : 2022-08-31DOI: 10.31718/mep.2022.26.3-4.07
V.H. Kravchenko, A. Kravchenko, Y. Yemchenko, M. Dudchenko
The problem of antibiotic resistance is currently one of the most urgent challenges for public health at the global level. An assessment by international experts shows that the resistance of microorganisms to antimicrobial agents is the cause of more than 700.000 deaths annually. Hence, only in the countries of the European Union, more than 25 thousand people die every year from infections caused by antibiotic-resistant bacteria. Despite the widespread use of systemic antibiotics in all fields of medicine, topical treatment of pathological processes continues to successfully serve in dermatology, gynecology, pediatrics, surgery, dentistry, and other areas of healthcare. Worldwide, one can observe a significantly increased interest in the development of topical antiseptic (non-antibiotic by origin) agents and their introduction into clinical practice, both for separate use and in combination with specific medications of systemic action (iodine derivatives, chlorhexidine bigluconate, cidipol, cimesol, etc.). We analyzed the current crisis situation in medicine and its causes related to the progressive polyresistance of the microbiome to antibiotics. The paper provides an overview of modern antibacterial, antibiotic and antiseptic agents on the domestic pharmaceutical market. We draw the attention of scientists and the creative medical community to the insufficient number of domestic innovative developments of antibacterial drugs and the importance of a demanding attitude to antibiotic treatment in connection with polyresistance of microbial flora. The study emphasizes that the development of new non-toxic medicinal products and a wider introduction of already known topical antibacterial, antiseptic, and anti-inflammatory agents with proven effectiveness and a scientifically based application scheme are extremely relevant and necessary under conditions of antibiotic resistance of the microbiome.
{"title":"TOPICAL ANTIBACTERIAL AGENTS UNDER CONDITIONS OF ANTIBIOTIC RESISTANCE OF THE MICROBIOME (AN ANALYTICAL REVIEW OF THE PROBLEM AND PROSPECTS FOR THE DEVELOPMENT OF NEW TOPICAL ANTIBACTERIAL (ANTISEPTIC) AGENTS)","authors":"V.H. Kravchenko, A. Kravchenko, Y. Yemchenko, M. Dudchenko","doi":"10.31718/mep.2022.26.3-4.07","DOIUrl":"https://doi.org/10.31718/mep.2022.26.3-4.07","url":null,"abstract":"The problem of antibiotic resistance is currently one of the most urgent challenges for public health at the global level. An assessment by international experts shows that the resistance of microorganisms to antimicrobial agents is the cause of more than 700.000 deaths annually. Hence, only in the countries of the European Union, more than 25 thousand people die every year from infections caused by antibiotic-resistant bacteria. Despite the widespread use of systemic antibiotics in all fields of medicine, topical treatment of pathological processes continues to successfully serve in dermatology, gynecology, pediatrics, surgery, dentistry, and other areas of healthcare. Worldwide, one can observe a significantly increased interest in the development of topical antiseptic (non-antibiotic by origin) agents and their introduction into clinical practice, both for separate use and in combination with specific medications of systemic action (iodine derivatives, chlorhexidine bigluconate, cidipol, cimesol, etc.). We analyzed the current crisis situation in medicine and its causes related to the progressive polyresistance of the microbiome to antibiotics. The paper provides an overview of modern antibacterial, antibiotic and antiseptic agents on the domestic pharmaceutical market. We draw the attention of scientists and the creative medical community to the insufficient number of domestic innovative developments of antibacterial drugs and the importance of a demanding attitude to antibiotic treatment in connection with polyresistance of microbial flora. The study emphasizes that the development of new non-toxic medicinal products and a wider introduction of already known topical antibacterial, antiseptic, and anti-inflammatory agents with proven effectiveness and a scientifically based application scheme are extremely relevant and necessary under conditions of antibiotic resistance of the microbiome.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44339318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.31718/mep.2022.26.3-4.09
O. Sherstyuk, Y. Sarychev, S. M. Suprunenko, S. A. Sukhomlin, G. L. Pustovoit
We conducted an analytical review of the literature on the problem of bladder decompensation in patients with benign prostatic hyperplasia. Benign prostatic hyperplasia is one of the most common diseases in aging men. As is known, with the development of benign prostatic hyperplasia due to infravesicular obstruction, the resistance to urine flow increases. As a result of a prolonged overload, the bladder is restructured, and it goes through three successive stages: compensation, subcompensation, and decompensation. Irreversible changes develop in the epithelial, muscular, and nerve tissues of the bladder. With benign prostatic hyperplasia due to intravesical hypertension, persistent microcirculation disorders occur in the walls of the bladder, which leads to the appearance of chronic detrusor ischemia, and can be a predictor of its fibrotic changes and decompensation. There is a correlation between the pathology of the vascular system and the development of symptoms of the lower urinary tract against the background of benign prostatic hyperplasia. Improvement of lower urinary tract perfusion can be considered a therapeutic strategy for the treatment of bladder dysfunction.
{"title":"DECOMPENSATED URINARY BLADDER DUE TO BENIGN PROSTATIC HYPERPLASIA (LITERATURE REVIEW)","authors":"O. Sherstyuk, Y. Sarychev, S. M. Suprunenko, S. A. Sukhomlin, G. L. Pustovoit","doi":"10.31718/mep.2022.26.3-4.09","DOIUrl":"https://doi.org/10.31718/mep.2022.26.3-4.09","url":null,"abstract":"We conducted an analytical review of the literature on the problem of bladder decompensation in patients with benign prostatic hyperplasia. Benign prostatic hyperplasia is one of the most common diseases in aging men. As is known, with the development of benign prostatic hyperplasia due to infravesicular obstruction, the resistance to urine flow increases. As a result of a prolonged overload, the bladder is restructured, and it goes through three successive stages: compensation, subcompensation, and decompensation. Irreversible changes develop in the epithelial, muscular, and nerve tissues of the bladder. With benign prostatic hyperplasia due to intravesical hypertension, persistent microcirculation disorders occur in the walls of the bladder, which leads to the appearance of chronic detrusor ischemia, and can be a predictor of its fibrotic changes and decompensation. There is a correlation between the pathology of the vascular system and the development of symptoms of the lower urinary tract against the background of benign prostatic hyperplasia. Improvement of lower urinary tract perfusion can be considered a therapeutic strategy for the treatment of bladder dysfunction.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46440026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.31718/mep.2022.26.3-4.05
H. Morokhovets, Y. Lysanets, O. Bieliaieva, S. Stetsenko, O. Shlykova
This paper analyzes the experience of introduction of distance learning in Ukraine, explores the efficiency of online learning in comparison with the classroom form of education, and identifies the role of motivation in the process of distance learning and the factors influencing the effectiveness of online learning. The aim of this research is to determine, theoretically substantiate and experimentally test the effectiveness of distance learning at a medical university. The authors analyzed the results of a survey of 315 medical and dental students of Poltava State Medical University at the second (Master's) and third (PhD) levels of higher education. Our research relies on the assertion that online learning influences not only the level of students’ motivation to continue their studies, but also the attitude toward their future profession. Therefore, upon receiving online training, students’ learning motives and perception of the attractiveness of the profession were used to measure the effectiveness of online mode of education. Distance learning aims to individualize the process of acquiring knowledge remotely using modern information and communication technologies. At the same time, it is necessary to monitor the learning outcomes and examine their dependence on the growing popularity of online learning in the world. We developed a questionnaire based on Donald Kirkpatrick’s model and applied the method of studying the attractiveness factors of the profession. 85.49% of respondents demonstrated their general impression of the organization of distance learning as positive (271 respondents). 74.13% of respondents were satisfied with the organization of distance learning at the university. To the question “How clearly do you understand how to apply the knowledge acquired through distance learning?” according to the scale from 1 to 5 (1 – not clear at all, 5 – very clear) respondents distributed their votes as follows – 1.58%, 7.26%, 29.97%, 43.53% and 17.66% respectively. The results of the survey on this issue correlate with the results of the test control conducted within the survey (r = 0.31). Experimental testing showed differences between the general impression of the organization of distance learning among students and the level of knowledge they acquired during distance learning. The level at which students determined the complexity of work during distance learning did not correlate with the results of test control of respondents (r=-0.04745, р=0.4028), and the age of respondents (r=0.1379, р=0.0242). The level of technical skills in working with software and web resources depended on the age of respondents (r=0.2432, р<0.0001) and did not correlate with the level at which students determined the complexity of work during distance learning (r=0.0818, р=0.1826), and the level general impression of studying the discipline (r=-0.0972, р=0.1130). The presence of previous experience of distance learning did not correlate with the performance i
{"title":"A STUDY OF THE EFFECTIVENESS OF DISTANCE LEARNING AT A MEDICAL UNIVERSITY IN UKRAINE","authors":"H. Morokhovets, Y. Lysanets, O. Bieliaieva, S. Stetsenko, O. Shlykova","doi":"10.31718/mep.2022.26.3-4.05","DOIUrl":"https://doi.org/10.31718/mep.2022.26.3-4.05","url":null,"abstract":"This paper analyzes the experience of introduction of distance learning in Ukraine, explores the efficiency of online learning in comparison with the classroom form of education, and identifies the role of motivation in the process of distance learning and the factors influencing the effectiveness of online learning. The aim of this research is to determine, theoretically substantiate and experimentally test the effectiveness of distance learning at a medical university. The authors analyzed the results of a survey of 315 medical and dental students of Poltava State Medical University at the second (Master's) and third (PhD) levels of higher education. Our research relies on the assertion that online learning influences not only the level of students’ motivation to continue their studies, but also the attitude toward their future profession. Therefore, upon receiving online training, students’ learning motives and perception of the attractiveness of the profession were used to measure the effectiveness of online mode of education. Distance learning aims to individualize the process of acquiring knowledge remotely using modern information and communication technologies. At the same time, it is necessary to monitor the learning outcomes and examine their dependence on the growing popularity of online learning in the world. We developed a questionnaire based on Donald Kirkpatrick’s model and applied the method of studying the attractiveness factors of the profession. 85.49% of respondents demonstrated their general impression of the organization of distance learning as positive (271 respondents). 74.13% of respondents were satisfied with the organization of distance learning at the university. To the question “How clearly do you understand how to apply the knowledge acquired through distance learning?” according to the scale from 1 to 5 (1 – not clear at all, 5 – very clear) respondents distributed their votes as follows – 1.58%, 7.26%, 29.97%, 43.53% and 17.66% respectively. The results of the survey on this issue correlate with the results of the test control conducted within the survey (r = 0.31). Experimental testing showed differences between the general impression of the organization of distance learning among students and the level of knowledge they acquired during distance learning. The level at which students determined the complexity of work during distance learning did not correlate with the results of test control of respondents (r=-0.04745, р=0.4028), and the age of respondents (r=0.1379, р=0.0242). The level of technical skills in working with software and web resources depended on the age of respondents (r=0.2432, р<0.0001) and did not correlate with the level at which students determined the complexity of work during distance learning (r=0.0818, р=0.1826), and the level general impression of studying the discipline (r=-0.0972, р=0.1130). The presence of previous experience of distance learning did not correlate with the performance i","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42562884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.31718/mep.2022.26.3-4.08
V.H. Kravchenko, Y. Yemchenko, A. Kravchenko, A. Dashchuk, M. Dudchenko, V.I. Kamieniev
We conducted an epidemiological analysis of the incidence of psoriasis in the world and Ukraine and examined the reasons for its permanent spread. The data on the incidence of psoriasis in certain regions of Ukraine were analyzed, testifying to the significant prevalence of this dermatosis, despite the lack of strict registration of diseases by region. The treatment of psoriatic disease, especially its complicated forms, is currently characterized by significant difficulties and does not provide a long-term remission. Therefore, the treatment of such patients must be carried out at specialized dermatovenerological institutions, which appropriate personnel, material conditions and special medical equipment (bacteriological, biochemical laboratories, X-ray office, highly qualified doctors, PUVA-therapy installations, solariums, etc.). On the basis of the obtained data, we outlined the main tasks of the dermatovenerological branch of our country in overcoming this difficult situation. In order to carry out decisive actions to improve the work in the fight against psoriatic disease and its consequences, it is necessary to establish accounting and reporting at dermatological institutions of municipal and private structures regarding morbidity. It is necessary to create a clear plan of measures in order to detect, treat and prevent the development of complications of dermatosis as early as possible. With the participation of the Ukrainian Association of Dermatovenereologists and Cosmetologists (UALDVC), an algorithm and protocols for the treatment of patients with various clinical types and forms of the disease should be developed, taking into account the latest national and international scientific achievements. Only the joint efforts of the professional medical association of dermatologists and a significant part of the medical community (pediatricians, cardiologists, endocrinologists, immunologists) under the leadership of the National Health Service and the Ministry of Healthcare of Ukraine can overcome the problem, because the epidemiological and therapeutic issues of psoriatic disease are not exclusively dermatological problems.
{"title":"EPIDEMIOLOGICAL AND THERAPEUTIC ISSUES OF PSORIATIC DISEASE","authors":"V.H. Kravchenko, Y. Yemchenko, A. Kravchenko, A. Dashchuk, M. Dudchenko, V.I. Kamieniev","doi":"10.31718/mep.2022.26.3-4.08","DOIUrl":"https://doi.org/10.31718/mep.2022.26.3-4.08","url":null,"abstract":"We conducted an epidemiological analysis of the incidence of psoriasis in the world and Ukraine and examined the reasons for its permanent spread. The data on the incidence of psoriasis in certain regions of Ukraine were analyzed, testifying to the significant prevalence of this dermatosis, despite the lack of strict registration of diseases by region. The treatment of psoriatic disease, especially its complicated forms, is currently characterized by significant difficulties and does not provide a long-term remission. Therefore, the treatment of such patients must be carried out at specialized dermatovenerological institutions, which appropriate personnel, material conditions and special medical equipment (bacteriological, biochemical laboratories, X-ray office, highly qualified doctors, PUVA-therapy installations, solariums, etc.). On the basis of the obtained data, we outlined the main tasks of the dermatovenerological branch of our country in overcoming this difficult situation. In order to carry out decisive actions to improve the work in the fight against psoriatic disease and its consequences, it is necessary to establish accounting and reporting at dermatological institutions of municipal and private structures regarding morbidity. It is necessary to create a clear plan of measures in order to detect, treat and prevent the development of complications of dermatosis as early as possible. With the participation of the Ukrainian Association of Dermatovenereologists and Cosmetologists (UALDVC), an algorithm and protocols for the treatment of patients with various clinical types and forms of the disease should be developed, taking into account the latest national and international scientific achievements. Only the joint efforts of the professional medical association of dermatologists and a significant part of the medical community (pediatricians, cardiologists, endocrinologists, immunologists) under the leadership of the National Health Service and the Ministry of Healthcare of Ukraine can overcome the problem, because the epidemiological and therapeutic issues of psoriatic disease are not exclusively dermatological problems.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43897968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.31718/mep.2022.26.3-4.02
O. Vovk, I. A. Golovanova
Breast cancer is the most common form of cancer in women, its share in the structure of all oncological morbidity in the European region is 28%. Breast cancer is the leading cause of cancer-related death in women. We analyzed the statistical data of the Ministry of Healthcare of Ukraine for 2012–2021, data of the National Cancer Registry of Ukraine, and data of the European Union of WHO as well as form No. 7 “Report on morbidity of malignant neoplasms”, Poltava. The analysis of dynamics from 2012-2021 was carried out. Data entry and statistical analysis were performed using IBM Statistical Package for the Social Science (IBM SPSS) version 25.0. The comparative examination of the incidence of malignant neoplasms of the breast and cervix in the female population of the Poltava region with the indicators for Ukraine demonstrates that neoplasms of the breast in women of the Poltava region occur 21.2% more often than in Ukraine as a whole, at the same time, cervical cancer among women of the Poltava region is registered 33.7% more often than in Ukraine. Over the period of 10 years, the mortality of the female population from malignant neoplasms of the breast and cervix has shown slight fluctuations. When compared with 2012, the mortality of women from cervical cancer tends to decrease. Hence, in 2020, the rate decreased by 13.6% (from 9.2 per 100.000 people in 2012 to 7.95 per 100.000 people in 2020). However, in 2021, this indicator increased to 9.3 per 100.000 people. The prevalence of breast neoplasms among the female population of the Poltava region indicates a 41.4% increase over the past 10 years (601.7 per 100.000 people in 2012 to 850.7 per 100.000 people in 2021). Over the past 10 years, the prevalence of cervical cancer tended to increase (+ 26.1%). In 2021, compared to the previous year, there was a slight reduction in the registration of this pathology, and there was also a drop in the growth rate (241.3 per 100.000 people in 2012 to 304.3 per 100.000 people in 2021).
{"title":"DYNAMICS OF INDICATIONS OF INCIDENCE OF MALIGNANT NEUTRALS OF THE MAMMARY GLAND AND CERVIX AMONG THE FEMALE POPULATION OF POLTAVA REGION","authors":"O. Vovk, I. A. Golovanova","doi":"10.31718/mep.2022.26.3-4.02","DOIUrl":"https://doi.org/10.31718/mep.2022.26.3-4.02","url":null,"abstract":"Breast cancer is the most common form of cancer in women, its share in the structure of all oncological morbidity in the European region is 28%. Breast cancer is the leading cause of cancer-related death in women. We analyzed the statistical data of the Ministry of Healthcare of Ukraine for 2012–2021, data of the National Cancer Registry of Ukraine, and data of the European Union of WHO as well as form No. 7 “Report on morbidity of malignant neoplasms”, Poltava. The analysis of dynamics from 2012-2021 was carried out. Data entry and statistical analysis were performed using IBM Statistical Package for the Social Science (IBM SPSS) version 25.0. The comparative examination of the incidence of malignant neoplasms of the breast and cervix in the female population of the Poltava region with the indicators for Ukraine demonstrates that neoplasms of the breast in women of the Poltava region occur 21.2% more often than in Ukraine as a whole, at the same time, cervical cancer among women of the Poltava region is registered 33.7% more often than in Ukraine. Over the period of 10 years, the mortality of the female population from malignant neoplasms of the breast and cervix has shown slight fluctuations. When compared with 2012, the mortality of women from cervical cancer tends to decrease. Hence, in 2020, the rate decreased by 13.6% (from 9.2 per 100.000 people in 2012 to 7.95 per 100.000 people in 2020). However, in 2021, this indicator increased to 9.3 per 100.000 people. The prevalence of breast neoplasms among the female population of the Poltava region indicates a 41.4% increase over the past 10 years (601.7 per 100.000 people in 2012 to 850.7 per 100.000 people in 2021). Over the past 10 years, the prevalence of cervical cancer tended to increase (+ 26.1%). In 2021, compared to the previous year, there was a slight reduction in the registration of this pathology, and there was also a drop in the growth rate (241.3 per 100.000 people in 2012 to 304.3 per 100.000 people in 2021).","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45490673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.31718/mep.2022.26.3-4.01
H. Morokhovets, I. Kaidashev
Digital epidemiology resources are actively used for the timely response of the health care system to the emergence and spread of diseases. Analytical methods applicable to time series of data are used for detailed analysis of seasonal fluctuations of infectious diseases. Together with the Google Trends (GT) tool, such methods allow modeling the dynamics of diseases in real-time and for future periods. Given that the COVID-19 pandemic is still at an early stage of development, new methods of epidemiological surveillance of the disease will be able to ensure a timely response of the health care system to it. The aim of this research is to study the use of GT resources to build a mathematical model for the prognosis of the COVID-19 incidence in Ukraine in real time and for future periods. Materials and methods. In the course of the study, we used the GT tool to search Google queries “ковід, ковид, COVID-19” (KKC). Data on morbidity in Ukraine were obtained using the web resource: https://index.minfin.com.ua/ua/reference/coronavirus/ukraine/. Excel, Eviews, and StatPlus software packages were used to analyze time series, construct periodograms, correlograms, and mathematical models. The mathematical model of morbidity dynamics was built based on statistical exponential smoothing. Results. As Cyrillic equivalents of the term COVID-19, Ukrainians use the queries “кові(и)д”. Correlograms of KKC requests and actual incidence show seasonal fluctuations of the same frequency, and singular spectral analysis revealed statistically significant peaks. Based on statistical exponential smoothing, a prognostic model for the incidence of COVID-19 for 2022-2024 was built, which is reliable according to the criteria of accuracy and the results of the Dickey-Fuller test. Conclusions. The GT tool is a reliable source of data for studying the dynamics of the spread of COVID-19. Together with the use of additive time series models, it allows for a real-time reliable prognosis of the development of the disease. The presented approach to modeling the dynamics of the spread of COVID-19 can be used to track outbreaks of the disease and respond promptly to them both on a national and local scale.
{"title":"A MATHEMATICAL MODEL FOR PROGNOSIS OF THE COVID-19 INCIDENCE IN UKRAINE USING GOOGLE TRENDS RESOURCES IN REAL-TIME AND FOR THE FUTURE PERIOD","authors":"H. Morokhovets, I. Kaidashev","doi":"10.31718/mep.2022.26.3-4.01","DOIUrl":"https://doi.org/10.31718/mep.2022.26.3-4.01","url":null,"abstract":"Digital epidemiology resources are actively used for the timely response of the health care system to the emergence and spread of diseases. Analytical methods applicable to time series of data are used for detailed analysis of seasonal fluctuations of infectious diseases. Together with the Google Trends (GT) tool, such methods allow modeling the dynamics of diseases in real-time and for future periods. Given that the COVID-19 pandemic is still at an early stage of development, new methods of epidemiological surveillance of the disease will be able to ensure a timely response of the health care system to it. The aim of this research is to study the use of GT resources to build a mathematical model for the prognosis of the COVID-19 incidence in Ukraine in real time and for future periods. Materials and methods. In the course of the study, we used the GT tool to search Google queries “ковід, ковид, COVID-19” (KKC). Data on morbidity in Ukraine were obtained using the web resource: https://index.minfin.com.ua/ua/reference/coronavirus/ukraine/. Excel, Eviews, and StatPlus software packages were used to analyze time series, construct periodograms, correlograms, and mathematical models. The mathematical model of morbidity dynamics was built based on statistical exponential smoothing. Results. As Cyrillic equivalents of the term COVID-19, Ukrainians use the queries “кові(и)д”. Correlograms of KKC requests and actual incidence show seasonal fluctuations of the same frequency, and singular spectral analysis revealed statistically significant peaks. Based on statistical exponential smoothing, a prognostic model for the incidence of COVID-19 for 2022-2024 was built, which is reliable according to the criteria of accuracy and the results of the Dickey-Fuller test. Conclusions. The GT tool is a reliable source of data for studying the dynamics of the spread of COVID-19. Together with the use of additive time series models, it allows for a real-time reliable prognosis of the development of the disease. The presented approach to modeling the dynamics of the spread of COVID-19 can be used to track outbreaks of the disease and respond promptly to them both on a national and local scale.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43497281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-15DOI: 10.31718/mep.2022.26.1-2.06
M. Rud, V. Shepitko, Y. Stetsuk, O. Akimov
The development of the inflammatory process in the liver, including under the influence of hepatitis B and C viruses, is controlled by cells of the immune system, namely, sinusoidal endothelial cells, Ito cells and Kupffer cells. Macrophages play one of the key roles in creating the line of defense. The way in which specific populations of macrophages contribute to liver disease and regeneration is a matter of constant debate. Therefore, identifying the characteristics of these populations of human macrophages is of undeniable value in studying their role in the development of liver pathology. The flavonoid quercetin has capillary-stabilizing properties due to its antioxidant and membrane-stabilizing action. The aim of our study was to determine the changes in immunocompetent liver cells, both qualitative and quantitative, caused by inhibition of central testosterone synthesis in male rats due to the introduction of triptorelin acetate on the 270th day, and the potential effect of quercetin on morphology and liver antigen-presenting cells count against the background of previous administration of triptorelin acetate solution. The experiments were performed on 30 adult male white rats. Rats were divided into 3 groups: control (10), experimental I (10), and experimental II (10). Animals from experimental group I were injected triptorelin acetate subcutaneously at a dose of 0.3 mg of active substance per kg of body weight. In experimental group II, animals received triptorelin acetate in the same dosage and quercetin 100 mg per kg body weight 3 times a week, whereas the control group was administered saline. We conducted biochemical studies in 10% liver tissue homogenate. The main production of superoxide anionic radical (SAR) and superoxide dismutase activity were determined. Peroxynitrite and superoxide anion radical are powerful oxidants that can damage biological polymers (DNA, proteins and biological membranes) and lead to the development of oxidative-nitrosative stress.
{"title":"THE EFFECT OF QUERCETIN ON MORPHOLOGICAL AND BIOCHEMICAL CHANGES IN RAT LIVER UNDER 270TH DAY CENTRAL DEPRIVATION OF LUTEINIZING HORMONE SYNTHESIS","authors":"M. Rud, V. Shepitko, Y. Stetsuk, O. Akimov","doi":"10.31718/mep.2022.26.1-2.06","DOIUrl":"https://doi.org/10.31718/mep.2022.26.1-2.06","url":null,"abstract":"The development of the inflammatory process in the liver, including under the influence of hepatitis B and C viruses, is controlled by cells of the immune system, namely, sinusoidal endothelial cells, Ito cells and Kupffer cells. Macrophages play one of the key roles in creating the line of defense. The way in which specific populations of macrophages contribute to liver disease and regeneration is a matter of constant debate. Therefore, identifying the characteristics of these populations of human macrophages is of undeniable value in studying their role in the development of liver pathology. The flavonoid quercetin has capillary-stabilizing properties due to its antioxidant and membrane-stabilizing action. The aim of our study was to determine the changes in immunocompetent liver cells, both qualitative and quantitative, caused by inhibition of central testosterone synthesis in male rats due to the introduction of triptorelin acetate on the 270th day, and the potential effect of quercetin on morphology and liver antigen-presenting cells count against the background of previous administration of triptorelin acetate solution. The experiments were performed on 30 adult male white rats. Rats were divided into 3 groups: control (10), experimental I (10), and experimental II (10). Animals from experimental group I were injected triptorelin acetate subcutaneously at a dose of 0.3 mg of active substance per kg of body weight. In experimental group II, animals received triptorelin acetate in the same dosage and quercetin 100 mg per kg body weight 3 times a week, whereas the control group was administered saline. We conducted biochemical studies in 10% liver tissue homogenate. The main production of superoxide anionic radical (SAR) and superoxide dismutase activity were determined. Peroxynitrite and superoxide anion radical are powerful oxidants that can damage biological polymers (DNA, proteins and biological membranes) and lead to the development of oxidative-nitrosative stress.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43421371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-15DOI: 10.31718/mep.2022.26.1-2.08
Дмитро Михайлович Король, Дмитро Данилович Кіндій, П.Д. Кіндій, О.Д. Оджубейська, Катерина Дмитрівна Тончева
The conducted analysis of the scientific literature has shown that the photogrammetric method of images acquisition has long been used in various fields of science and industry. Its advantages include the simplicity and affordability of technical implementation, high accuracy of the obtained data, complete contactless application and the opportunity for the digital processing of an enormous amount of information over a short period of time, acquisition of a virtual model of high accuracy. The testing of photogrammetry in medical practice has resulted in the indication of promising areas of its application and improvement. They have been specified in terms of the dental field, being directed to the acquisition of three-dimensional models of the head, jaws, alveolar processes, periodontal tissues, dentitions and individual teeth as well as to the reproduction of central occlusion, jaw articulation correlation and to three-dimensional implant and denture positioning. Numerous in vitro and in vivo studies have proven the competitiveness of photogrammetry as compared to 3-D scanning methods. however, some problems associated with its application remain unresolved. On the one hand, photogrammetry experts still lack some understanding of special requests of dental diagnostics, while dentists are still unaware of photogrammetry functional opportunities. Moreover, certain procedural requirements as for the angle, lighting, distance, etc. sufficiently restrict its technical capacity. In any case, most researchers point to the need for in-depth scientific studies of the actual practical photogrammetry opportunities, while further prospects for the introduction of this method are associated with the technical improvement of the equipment adapted to the peculiarities of dental practice.
{"title":"ФОТОГРАММЕТРІЯ У СТОМАТОЛОГІЧНІЙ ПРАКТИЦІ (ОГЛЯД ЛІТЕРАТУРИ)","authors":"Дмитро Михайлович Король, Дмитро Данилович Кіндій, П.Д. Кіндій, О.Д. Оджубейська, Катерина Дмитрівна Тончева","doi":"10.31718/mep.2022.26.1-2.08","DOIUrl":"https://doi.org/10.31718/mep.2022.26.1-2.08","url":null,"abstract":"The conducted analysis of the scientific literature has shown that the photogrammetric method of images acquisition has long been used in various fields of science and industry. Its advantages include the simplicity and affordability of technical implementation, high accuracy of the obtained data, complete contactless application and the opportunity for the digital processing of an enormous amount of information over a short period of time, acquisition of a virtual model of high accuracy. The testing of photogrammetry in medical practice has resulted in the indication of promising areas of its application and improvement. They have been specified in terms of the dental field, being directed to the acquisition of three-dimensional models of the head, jaws, alveolar processes, periodontal tissues, dentitions and individual teeth as well as to the reproduction of central occlusion, jaw articulation correlation and to three-dimensional implant and denture positioning. Numerous in vitro and in vivo studies have proven the competitiveness of photogrammetry as compared to 3-D scanning methods. however, some problems associated with its application remain unresolved. On the one hand, photogrammetry experts still lack some understanding of special requests of dental diagnostics, while dentists are still unaware of photogrammetry functional opportunities. Moreover, certain procedural requirements as for the angle, lighting, distance, etc. sufficiently restrict its technical capacity. In any case, most researchers point to the need for in-depth scientific studies of the actual practical photogrammetry opportunities, while further prospects for the introduction of this method are associated with the technical improvement of the equipment adapted to the peculiarities of dental practice.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41866627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-15DOI: 10.31718/mep.2022.26.1-2.05
Р. В. Луценко, Антонина Григорьевна Сидоренко, Наталія Власенко, О. А. Луценко
Derivatives of 2-oxoindoline demonstrate significant biological and pharmacological activity, including diuretic, anti-inflammatory, antitumor, antiviral, antibacterial, analgesic, sedative, anticonvulsant and other effects. The aim of this research is to establish the average effective dose of 2-hydroxy-n-naphthalene-1-yl-2-(2-oxo-1,2-dihydro-indol-3-ylidene)-acetamide (compound 18) as a potential anxiolytic, as well as its therapeutic index. Materials and methods of research. The experiments were performed on 36 albino adult male Wistar rats. The average effective dose (ED50) of compound 18 for anxiolytic activity was investigated in the «punishable behavior» test. Rats were divided into 6 groups of 6 animals each. The dose range for the intraperitoneal route of administration was (1, 3, 6; 12, 24, 48 mg/kg). Results and discussion. The «punishable behavior» model, Vogel variant, determined the average effective dose (ED50) and dose-response relationship for 2-hydroxy-n-naphthalene-1-yl-2-(2-oxo-1,2-dihydro-indol-3-ylidene)-acetamide (compound 18) with a single intraperitoneal injection. Analysis of the results shows that the maximum dose that did not cause the effect was 1.0 mg/kg, the minimum effective dose ED16 was 4.5 mg/kg, and the maximum effective dose ED100 was 48 mg/kg. Conclusion. Experimentally determined ED50 of compound 18 in rats when administered intraperitoneally in the «punishable behavior» test, variant Vogel, was 11.9±2.85 mg/kg. The ED50 confidence margins were (4.92÷18.9) mg/kg. According to the therapeutic index, substance 18 exceeds diazepam by 14.8 times.
{"title":"ВСТАНОВЛЕННЯ СЕРЕДНЬОЇ ЕФЕКТИВНОЇ ДОЗИ 2-ГІДРОКСИ-N- НАФТАЛЕН-1-ІЛ-2-(2-OКСО-1,2-ДИГІДРО-ІНДОЛ-3-ІЛІДЕН)-АЦЕТАМІДУ НА МОДЕЛІ «ПОВЕДІНКА, ЩО КАРАЄТЬСЯ»","authors":"Р. В. Луценко, Антонина Григорьевна Сидоренко, Наталія Власенко, О. А. Луценко","doi":"10.31718/mep.2022.26.1-2.05","DOIUrl":"https://doi.org/10.31718/mep.2022.26.1-2.05","url":null,"abstract":"Derivatives of 2-oxoindoline demonstrate significant biological and pharmacological activity, including diuretic, anti-inflammatory, antitumor, antiviral, antibacterial, analgesic, sedative, anticonvulsant and other effects. The aim of this research is to establish the average effective dose of 2-hydroxy-n-naphthalene-1-yl-2-(2-oxo-1,2-dihydro-indol-3-ylidene)-acetamide (compound 18) as a potential anxiolytic, as well as its therapeutic index. Materials and methods of research. The experiments were performed on 36 albino adult male Wistar rats. The average effective dose (ED50) of compound 18 for anxiolytic activity was investigated in the «punishable behavior» test. Rats were divided into 6 groups of 6 animals each. The dose range for the intraperitoneal route of administration was (1, 3, 6; 12, 24, 48 mg/kg). Results and discussion. The «punishable behavior» model, Vogel variant, determined the average effective dose (ED50) and dose-response relationship for 2-hydroxy-n-naphthalene-1-yl-2-(2-oxo-1,2-dihydro-indol-3-ylidene)-acetamide (compound 18) with a single intraperitoneal injection. Analysis of the results shows that the maximum dose that did not cause the effect was 1.0 mg/kg, the minimum effective dose ED16 was 4.5 mg/kg, and the maximum effective dose ED100 was 48 mg/kg. Conclusion. Experimentally determined ED50 of compound 18 in rats when administered intraperitoneally in the «punishable behavior» test, variant Vogel, was 11.9±2.85 mg/kg. The ED50 confidence margins were (4.92÷18.9) mg/kg. According to the therapeutic index, substance 18 exceeds diazepam by 14.8 times.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43021505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-15DOI: 10.31718/mep.2022.26.1-2.04
Б. С. Кононов, С. М. Білаш
Neurological diseases are among the most common in Ukraine, especially given the development of technology in the food industry and the accelerated pace of life, which contributes to an increased number of food additives in nutrition products. The cerebellum is easily affected by adverse effects. Our research aimed to conduct a comparative analysis of immunomorphological changes of astrocytes with neurons in the cerebellar gray matter of rats at different periods of consuming food additives, namely monosodium glutamate (food additive E621), ponceau 4R (food additive E124) and sunset yellow (food additive E110), using glial acid fibrillar protein and NeuN-immunoreactivity reaction. White rats were used in this study. We applied the immunohistochemical marker GFAP to establish protoplasmic astrocytes, and paraffin sections for the Neun-immunoreactivity reaction. Student's T-criterion was used to compare quantitative values in dual series. The difference was considered reliable at values of p<0.05. As a result of the study, histological specimens demonstrated GFAP-positive cells with large perikaryon and numerical processes, which we identified as protoplasmic astrocytes, and NeuN-positive piriform structures, from whose narrowed apex 2-3 dendrites radiated to the molecular layer, and the latter in turn gave numerous branches. We identified these cells as piriform neurons or Purkinje cells. Experimental studies have shown that in both gray and white matter of the cerebellum, there are compensatory and adaptive processes aimed at partial restoration of structural components of the cerebellum, and GFAP-positive structures play a decisive role in this process as a fibrillar framework. Furthermore, the morphometric study found that in the dynamics of the experiment, the average number of NeuN-positive Purkinje cells of the ganglion layer of the cerebellar cortex of rats in different experimental groups (from 1 to 5) significantly increased at p˂0.05 as compared to the control group of animals.
{"title":"ПОРІВНЯЛЬНИЙ ІМУНО-МОРФОЛОГІЧНИЙ АНАЛІЗ АСТРОЦИТІВ ТА НЕЙРОЦИТІВ СІРОЇ РЕЧОВИНИ МОЗОЧКА ЩУРІВ ПІД ВПЛИВОМ КОМПЛЕКСУ ХАРЧОВИХ ДОБАВОК","authors":"Б. С. Кононов, С. М. Білаш","doi":"10.31718/mep.2022.26.1-2.04","DOIUrl":"https://doi.org/10.31718/mep.2022.26.1-2.04","url":null,"abstract":"Neurological diseases are among the most common in Ukraine, especially given the development of technology in the food industry and the accelerated pace of life, which contributes to an increased number of food additives in nutrition products. The cerebellum is easily affected by adverse effects. Our research aimed to conduct a comparative analysis of immunomorphological changes of astrocytes with neurons in the cerebellar gray matter of rats at different periods of consuming food additives, namely monosodium glutamate (food additive E621), ponceau 4R (food additive E124) and sunset yellow (food additive E110), using glial acid fibrillar protein and NeuN-immunoreactivity reaction. White rats were used in this study. We applied the immunohistochemical marker GFAP to establish protoplasmic astrocytes, and paraffin sections for the Neun-immunoreactivity reaction. Student's T-criterion was used to compare quantitative values in dual series. The difference was considered reliable at values of p<0.05. As a result of the study, histological specimens demonstrated GFAP-positive cells with large perikaryon and numerical processes, which we identified as protoplasmic astrocytes, and NeuN-positive piriform structures, from whose narrowed apex 2-3 dendrites radiated to the molecular layer, and the latter in turn gave numerous branches. We identified these cells as piriform neurons or Purkinje cells. Experimental studies have shown that in both gray and white matter of the cerebellum, there are compensatory and adaptive processes aimed at partial restoration of structural components of the cerebellum, and GFAP-positive structures play a decisive role in this process as a fibrillar framework. Furthermore, the morphometric study found that in the dynamics of the experiment, the average number of NeuN-positive Purkinje cells of the ganglion layer of the cerebellar cortex of rats in different experimental groups (from 1 to 5) significantly increased at p˂0.05 as compared to the control group of animals.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44297176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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