Pub Date : 2020-12-30DOI: 10.31718/mep.2020.24.5-6.04
M. O. Matokhniuk, I. Pashkova, V. Zhebel
Chronic heart failure (CHF) is one of the prognostic complications of essential hypertension (EH), which is the most common non-communicable disease in the world. The aim of the study is to improve the effectiveness of diagnosis of EH progression based on cluster analysis, which is based on anthropometric, laboratory and systemic and intracardiac hemodynamics in men 40-60 years. The study included 50 men with asymptomatic EH aged 50.62 ± 0.73 years and 50 men with EH complicated by CHF aged 51.86 ± 0.81 years. All participants underwent standard cardio-graphic examinations, the plasma concentration of cardiotrophin-1 (CT-1) in the blood was determined by enzyme-linked immunosorbent assay (ELISA) and rs8046707 of the CT-1 gene in venous blood samples using the PLR method. The phenotypic portrait of the patient was distinguished by cluster analysis.
{"title":"ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE","authors":"M. O. Matokhniuk, I. Pashkova, V. Zhebel","doi":"10.31718/mep.2020.24.5-6.04","DOIUrl":"https://doi.org/10.31718/mep.2020.24.5-6.04","url":null,"abstract":"Chronic heart failure (CHF) is one of the prognostic complications of essential hypertension (EH), which is the most common non-communicable disease in the world. The aim of the study is to improve the effectiveness of diagnosis of EH progression based on cluster analysis, which is based on anthropometric, laboratory and systemic and intracardiac hemodynamics in men 40-60 years. The study included 50 men with asymptomatic EH aged 50.62 ± 0.73 years and 50 men with EH complicated by CHF aged 51.86 ± 0.81 years. All participants underwent standard cardio-graphic examinations, the plasma concentration of cardiotrophin-1 (CT-1) in the blood was determined by enzyme-linked immunosorbent assay (ELISA) and rs8046707 of the CT-1 gene in venous blood samples using the PLR method. The phenotypic portrait of the patient was distinguished by cluster analysis.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41353082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.31718/mep.2020.24.5-6.02
Y. Yemchenko, K. Ishcheikin, I. Kaidashev
Psoriasis is one of the most common chronic recurrent systemic autoimmune multifactorial diseases, in which the skin, joints, internal organs and systems of the body are involved in the pathological process. Despite the significant prevalence of psoriasis and a large number of studies on this problem, there is still no single view on the pathogenesis of this dermatosis. To objectively understand the pathogenesis of psoriasis, it is necessary to take into account the insufficiently studied comorbidity of this pathology. Recently, an indisputable link between psoriasis and obesity has been proven. The scientific literature widely covers the issue of identical pathogenetic mechanisms of inflammatory processes in psoriasis and obesity. Given the current data on the role of systemic inflammation underlying the development of both psoriasis and obesity, the study of molecular mechanisms of its development and taking into account the role of proinflammatory nuclear transcription factors, thiazolidinediones are the pathogenetically justified drugs of choice for treatment of these diseases. In this study, we determined the effectiveness of using 15 mg of pioglitazone once a day for 6 months in the treatment of patients with extensive psoriasis vulgaris of moderate severity and concomitant grade І-ІІ alimentary obesity by clinical and immunological examination of systemic inflammation. Analyzing the results of the study, it was found that long-term use of pioglitazone, even in small doses, led to a decrease in systemic inflammation and contributed to a milder course of psoriasis in recurrence of the disease.
{"title":"APPLICATION OF PIOGLITAZONE IN THE COMPREHENSIVE TREATMENT OF PSORIATIC PATIENTS WITH CONCOMITANT ALIMENTARY OBESITY","authors":"Y. Yemchenko, K. Ishcheikin, I. Kaidashev","doi":"10.31718/mep.2020.24.5-6.02","DOIUrl":"https://doi.org/10.31718/mep.2020.24.5-6.02","url":null,"abstract":"Psoriasis is one of the most common chronic recurrent systemic autoimmune multifactorial diseases, in which the skin, joints, internal organs and systems of the body are involved in the pathological process. Despite the significant prevalence of psoriasis and a large number of studies on this problem, there is still no single view on the pathogenesis of this dermatosis. To objectively understand the pathogenesis of psoriasis, it is necessary to take into account the insufficiently studied comorbidity of this pathology. Recently, an indisputable link between psoriasis and obesity has been proven. The scientific literature widely covers the issue of identical pathogenetic mechanisms of inflammatory processes in psoriasis and obesity. Given the current data on the role of systemic inflammation underlying the development of both psoriasis and obesity, the study of molecular mechanisms of its development and taking into account the role of proinflammatory nuclear transcription factors, thiazolidinediones are the pathogenetically justified drugs of choice for treatment of these diseases. In this study, we determined the effectiveness of using 15 mg of pioglitazone once a day for 6 months in the treatment of patients with extensive psoriasis vulgaris of moderate severity and concomitant grade І-ІІ alimentary obesity by clinical and immunological examination of systemic inflammation. Analyzing the results of the study, it was found that long-term use of pioglitazone, even in small doses, led to a decrease in systemic inflammation and contributed to a milder course of psoriasis in recurrence of the disease.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46065651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.31718/mep.2020.24.5-6.05
G. Nevoit
The article presents the results of determining the clinical and diagnostic potential of using the electro-рhotonic emission analysis from human fingers during an objective structured clinical examination. The aim of the study is to assess the clinical and diagnostic capabilities of electro-рhotonic emission analysis in the reflection of systemic information energy processes of the human body to increase the effectiveness of measures to prevent and treat NCDs by improving their diagnosis and prevention through the introduction of modern science-intensive technologies and scientific magnetoelectrochemical concept of metabolism. The results of the оpen, non-randomized, controlled study of 56 functional respondents who do not systematically engage in sports are presented. The electro-рhotonic emission analysis was performed on a certified measuring device Bio-Well GDV Camera 2.0 (Bio-Well, Russia-USA). Different levels of functional status and different degrees of health were established as a result of the study. The method of electrophoton emission analysis allows us to calculate the parameters of the state of metabolism of substances at the tissue level and indirectly assess the general functional state of patients based on data processing regarding the intensity and nature of localization of photon emission from the fingers of the respondent. The method for the electro-рhotonic emission analysis is recommended by the authors for possible use in clinical medicine in order to objectively assess the energy status of the patient.
本文介绍了在客观结构化的临床检查中使用人类手指的电子-光子发射分析来确定临床和诊断潜力的结果。本研究的目的是评估电子发射分析在反映人体系统信息能量过程中的临床和诊断能力，通过引入现代科学密集型技术和科学代谢的磁电化学概念。本文介绍了对56名没有系统参与体育运动的功能性受访者进行的非随机对照研究的结果。在经过认证的测量设备Bio-Well GDV Camera 2.0（Bio-Well，俄罗斯-美国）上进行电子-光子发射分析。研究结果确定了不同水平的功能状态和不同程度的健康状况。电子光子发射分析方法使我们能够在组织水平上计算物质代谢状态的参数，并基于与受访者手指光子发射的强度和定位性质有关的数据处理来间接评估患者的一般功能状态。作者建议在临床医学中使用电子-光子发射分析方法，以客观评估患者的能量状态。
{"title":"POSSIBILITIES OF ELECTRO-PHOTONIC EMISSION ANALYSIS IN THE REPRESENTATION OF SYSTEM INFORMATION ENERGY PROCESSES OF THE HUMAN ORGANISM","authors":"G. Nevoit","doi":"10.31718/mep.2020.24.5-6.05","DOIUrl":"https://doi.org/10.31718/mep.2020.24.5-6.05","url":null,"abstract":"The article presents the results of determining the clinical and diagnostic potential of using the electro-рhotonic emission analysis from human fingers during an objective structured clinical examination. The aim of the study is to assess the clinical and diagnostic capabilities of electro-рhotonic emission analysis in the reflection of systemic information energy processes of the human body to increase the effectiveness of measures to prevent and treat NCDs by improving their diagnosis and prevention through the introduction of modern science-intensive technologies and scientific magnetoelectrochemical concept of metabolism. The results of the оpen, non-randomized, controlled study of 56 functional respondents who do not systematically engage in sports are presented. The electro-рhotonic emission analysis was performed on a certified measuring device Bio-Well GDV Camera 2.0 (Bio-Well, Russia-USA). Different levels of functional status and different degrees of health were established as a result of the study. The method of electrophoton emission analysis allows us to calculate the parameters of the state of metabolism of substances at the tissue level and indirectly assess the general functional state of patients based on data processing regarding the intensity and nature of localization of photon emission from the fingers of the respondent. The method for the electro-рhotonic emission analysis is recommended by the authors for possible use in clinical medicine in order to objectively assess the energy status of the patient.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44315483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.31718/mep.2020.24.5-6.01
I. Kaidashev, H. Morokhovets, V. Rodinkova, O. Bilous, L. Dubuske, Jean Bousquet
У статті представлено літературний огляд проблеми використання інноваційних інструментів веб-спостереження, зокрема Google Trends (GT), з метою визначення точного початку сезону спор цвілі. Алергія на цвіль є значним пусковим механізмом розвитку поширених респіраторних розладів – алергічного риніту та астми, хронічного обструктивного захворювання легень тощо. Метою дослідження було вивчення сезонності запитів GT в Україні з кількістю спор Alternaria. Спори роду Alternaria – найпоширеніша складова повітря у всіх регіонах світу, що утворюють інфекційний посівний матеріал численних видів рослин, а також спричиняють важку інгаляційну алергію. Точне визначення настання сезону спор цвілі є вирішальним для підтвердження діагнозу алергії на цвіль та розробки персоналізованого лікування для пацієнтів з алергічним ринітом та астмою. Найбільш комплексним підходом є розвиток загальноєвропейської мережі моніторингу, яка поєднує всі ці стратегії. GT може бути корисним інструментом для диференціації сезонів спор Alternaria, особливо коли вони співпадають з сезоном цвітіння амброзії. Чотири терміни "нежить", "сльози", "задишка" та "кашель" (кирилицею) слід використовувати в Україні для пояснення впливу спор Alternaria. Поєднання запитів GT з кількістю спор може бути використано в масштабних епідеміологічних дослідженнях. Розвиток загальноєвропейської сигнальної мережі моніторингу алергічних захворювань зумовлює проблему перекладу пошукових термінів різними європейськими мовами. Отримані результати можна використовувати як ефективний інструмент запобігання або мінімізації впливу алергену на пацієнтів під час сезону Alternaria.
{"title":"PATTERNS IN GOOGLE TRENDS TERMS REPORTING RHINITIS AND ALTERNARIA SEASON IN UKRAINE","authors":"I. Kaidashev, H. Morokhovets, V. Rodinkova, O. Bilous, L. Dubuske, Jean Bousquet","doi":"10.31718/mep.2020.24.5-6.01","DOIUrl":"https://doi.org/10.31718/mep.2020.24.5-6.01","url":null,"abstract":"У статті представлено літературний огляд проблеми використання інноваційних інструментів веб-спостереження, зокрема Google Trends (GT), з метою визначення точного початку сезону спор цвілі. Алергія на цвіль є значним пусковим механізмом розвитку поширених респіраторних розладів – алергічного риніту та астми, хронічного обструктивного захворювання легень тощо. Метою дослідження було вивчення сезонності запитів GT в Україні з кількістю спор Alternaria. Спори роду Alternaria – найпоширеніша складова повітря у всіх регіонах світу, що утворюють інфекційний посівний матеріал численних видів рослин, а також спричиняють важку інгаляційну алергію. Точне визначення настання сезону спор цвілі є вирішальним для підтвердження діагнозу алергії на цвіль та розробки персоналізованого лікування для пацієнтів з алергічним ринітом та астмою. Найбільш комплексним підходом є розвиток загальноєвропейської мережі моніторингу, яка поєднує всі ці стратегії. GT може бути корисним інструментом для диференціації сезонів спор Alternaria, особливо коли вони співпадають з сезоном цвітіння амброзії. Чотири терміни \"нежить\", \"сльози\", \"задишка\" та \"кашель\" (кирилицею) слід використовувати в Україні для пояснення впливу спор Alternaria. Поєднання запитів GT з кількістю спор може бути використано в масштабних епідеміологічних дослідженнях. Розвиток загальноєвропейської сигнальної мережі моніторингу алергічних захворювань зумовлює проблему перекладу пошукових термінів різними європейськими мовами. Отримані результати можна використовувати як ефективний інструмент запобігання або мінімізації впливу алергену на пацієнтів під час сезону Alternaria.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48894037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.31718/mep.2020.24.5-6.03
М.О. Матохнюк, Ю.П. Пашкова, В. М. Жебель
Метою дослідження є удосконалення ефективності діагностики прогресування ессенціальної гіпертензії (ЕГ) на основі кластерного аналізу, який базується на антропометричних, лабораторних та показниках системної та внутрішньосерцевої гемодинаміки у чоловіків 40-60 років. У дослідження були залучені 50 чоловіків з асимптомною ЕГ у віці- 50,62±0,73 років та 50 чоловіків з ЕГ, що ускладнена хронічною серцевою недостатністю (ХСН), у віці- 51,86±0,81 років. Усім учасникам дослідження виконували стандартне ехокардіографічне обстеження, визначали плазмові концентрації кардіотрофіна-1 (КТ-1) в сироватці крові за допомогою імуноферментного аналізу (ІФА) та поліморфізму (rs8046707) гена КТ-1 у зразках венозної крові методом полімеразної ланцюгової реакції (ПЛР). За допомогою кластерного аналізу виділено фенотиповий портрет пацієнта.
{"title":"ФЕНОТИПОВИЙ ПОРТРЕТ ЕСЕНЦІАЛЬНОЇ ГІПЕРТЕНЗІЇ, ЯК ІНСТРУМЕНТ ПІДВИЩЕННЯ ЕФЕКТИВНОСТІ ЇЇ ДІАГНОСТИКИ ТА ПРОГРЕСУВАННЯ У ЧОЛОВІКІВ НОСІЇВ ПОЛІМОРФНИХ ВАРІАНТІВ ГЕНА КАРДІОТРОФІНА-1","authors":"М.О. Матохнюк, Ю.П. Пашкова, В. М. Жебель","doi":"10.31718/mep.2020.24.5-6.03","DOIUrl":"https://doi.org/10.31718/mep.2020.24.5-6.03","url":null,"abstract":"Метою дослідження є удосконалення ефективності діагностики прогресування ессенціальної гіпертензії (ЕГ) на основі кластерного аналізу, який базується на антропометричних, лабораторних та показниках системної та внутрішньосерцевої гемодинаміки у чоловіків 40-60 років. У дослідження були залучені 50 чоловіків з асимптомною ЕГ у віці- 50,62±0,73 років та 50 чоловіків з ЕГ, що ускладнена хронічною серцевою недостатністю (ХСН), у віці- 51,86±0,81 років. Усім учасникам дослідження виконували стандартне ехокардіографічне обстеження, визначали плазмові концентрації кардіотрофіна-1 (КТ-1) в сироватці крові за допомогою імуноферментного аналізу (ІФА) та поліморфізму (rs8046707) гена КТ-1 у зразках венозної крові методом полімеразної ланцюгової реакції (ПЛР). За допомогою кластерного аналізу виділено фенотиповий портрет пацієнта.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49143234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.31718/mep.2020.24.5-6.06
Ігор Леонідович Колісник
Вплив фторид-іона як хімічного агента впливає на метаболізм, зміна якого проявляється в функціональних і структурних змінах. До кінцевих стабільних метаболітів NO відносяться нітрит і нітрат-аніони (NO2, NO3), визначення концентрації яких є непрямим методом оцінки інтенсивності синтезу NO. Концентрація NO є головним фактором його чисельних біоефектів (регуляторного, захисного, пошкоджуючого). При низьких концентраціях NO переважають прямі ефекти, спрямовані на підтримку гомеостазу, наприклад, судинної, дихальної та нервової систем; при високих концентраціях NO – переважають непрямі ефекти, зумовлені, перш за все, утворенням пероксинітриту. Відомо, що при підвищенні в організмі швидкості вільнорадикальних реакцій NO може вступати у реакцію з супероксидним аніон-радикалом з утворенням пероксинітриту – високо реакційної сполуки з деструктивними властивостями по відношенню до білків і ліпідів. Пероральне введення щурам фториду натрію (ФН) у дозах 1/10 і 1/100 ДЛ50 призводить, протягом перших 30 діб, до підвищення у плазмі крові вмісту нітрит- і нітрат-аніонів, що опосередковано свідчить про надлишкову продукцію оксиду азоту, який у початкові терміни інтоксикації може виконувати компенсаторну роль, але у подальшому викликати патологічні реакції, пов’язані з активацією оксидативного стресу. Зниження нітрит- і нітрат-аніонів наприкінці тривалої дії ФН опосередковано свідчить про зменшення генерації оксиду азоту, що може бути пов’язано, зокрема, з підвищенням концентрації пероксинітриту в результаті використання оксиду азоту у реакції з супероксидним аніон-радикалом і дефіцитом антиоксидантних ферментів.
{"title":"ІНТЕНСИВНІСТЬ СИНТЕЗУ ОКСИДУ АЗОТУ У КРОВІ ЩУРІВ ПІД ВПЛИВОМ ФТОРИДУ НАТРІЮ","authors":"Ігор Леонідович Колісник","doi":"10.31718/mep.2020.24.5-6.06","DOIUrl":"https://doi.org/10.31718/mep.2020.24.5-6.06","url":null,"abstract":"Вплив фторид-іона як хімічного агента впливає на метаболізм, зміна якого проявляється в функціональних і структурних змінах. До кінцевих стабільних метаболітів NO відносяться нітрит і нітрат-аніони (NO2, NO3), визначення концентрації яких є непрямим методом оцінки інтенсивності синтезу NO. Концентрація NO є головним фактором його чисельних біоефектів (регуляторного, захисного, пошкоджуючого). При низьких концентраціях NO переважають прямі ефекти, спрямовані на підтримку гомеостазу, наприклад, судинної, дихальної та нервової систем; при високих концентраціях NO – переважають непрямі ефекти, зумовлені, перш за все, утворенням пероксинітриту. Відомо, що при підвищенні в організмі швидкості вільнорадикальних реакцій NO може вступати у реакцію з супероксидним аніон-радикалом з утворенням пероксинітриту – високо реакційної сполуки з деструктивними властивостями по відношенню до білків і ліпідів. Пероральне введення щурам фториду натрію (ФН) у дозах 1/10 і 1/100 ДЛ50 призводить, протягом перших 30 діб, до підвищення у плазмі крові вмісту нітрит- і нітрат-аніонів, що опосередковано свідчить про надлишкову продукцію оксиду азоту, який у початкові терміни інтоксикації може виконувати компенсаторну роль, але у подальшому викликати патологічні реакції, пов’язані з активацією оксидативного стресу. Зниження нітрит- і нітрат-аніонів наприкінці тривалої дії ФН опосередковано свідчить про зменшення генерації оксиду азоту, що може бути пов’язано, зокрема, з підвищенням концентрації пероксинітриту в результаті використання оксиду азоту у реакції з супероксидним аніон-радикалом і дефіцитом антиоксидантних ферментів.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42887295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.31718/mep.2020.24.5-6.08
Y. Lysanets, O. Bieliaieva, T. Purdenko, L. Ostrovska, H. Morokhovets
The article considers the communicative status of hedging in different genres of the English academic discourse. As a linguistic phenomenon, hedging is associated with the choice of a particular communication strategy, usually aimed at reducing the categorical nature of expressions. Hedging allows authors to limit the degree of reliability or validity of the judgment, to take off responsibility for accuracy of information in a statement, and to avoid critical interpretation. The English language training of researchers and teaching staff at medical universities has become a priority task in higher medical education. Therefore, the aim of the study was to examine and systematize the most common challenges in dealing with hedging linguistic constructions in the English academic discourse. The ability to understand and use hedging phrases correctly is an essential prerequisite of successful communication, intercultural reciprocal understanding and international cooperation in the context of rapid development of integration in Ukraine, which renders the present research relevant. The most commonly used hedging constructions, their significance and contextual role in professional communication have been analyzed. The authors have studied the linguistic features of hedging markers, and the functions of hedging constructions depending on the addresser’s intentions. The material of the research is the corpus of research articles and case reports obtained by the method of continuous sampling from the electronic database of medical publications “PubMed”. The analysis of hedging strategies is important to eliminate possible mistakes and avoid misunderstanding in medical communication. The study of the functional implementation of hedging on the basis of certain academic genres of the English medical discourse specifies the "doctor – patient" communicative situation, motivates the communicative behavior of narrative figures, and optimizes international professional communication. The authors believe that paying due attention to this linguistic phenomenon within the framework of the training PhDs and academic staff will promote scientific cooperation, thus contributing to the development of higher medical education in Ukraine.
{"title":"HEDGING STRATEGIES IN THE ENGLISH ACADEMIC DISCOURSE","authors":"Y. Lysanets, O. Bieliaieva, T. Purdenko, L. Ostrovska, H. Morokhovets","doi":"10.31718/mep.2020.24.5-6.08","DOIUrl":"https://doi.org/10.31718/mep.2020.24.5-6.08","url":null,"abstract":"The article considers the communicative status of hedging in different genres of the English academic discourse. As a linguistic phenomenon, hedging is associated with the choice of a particular communication strategy, usually aimed at reducing the categorical nature of expressions. Hedging allows authors to limit the degree of reliability or validity of the judgment, to take off responsibility for accuracy of information in a statement, and to avoid critical interpretation. The English language training of researchers and teaching staff at medical universities has become a priority task in higher medical education. Therefore, the aim of the study was to examine and systematize the most common challenges in dealing with hedging linguistic constructions in the English academic discourse. The ability to understand and use hedging phrases correctly is an essential prerequisite of successful communication, intercultural reciprocal understanding and international cooperation in the context of rapid development of integration in Ukraine, which renders the present research relevant. The most commonly used hedging constructions, their significance and contextual role in professional communication have been analyzed. The authors have studied the linguistic features of hedging markers, and the functions of hedging constructions depending on the addresser’s intentions. The material of the research is the corpus of research articles and case reports obtained by the method of continuous sampling from the electronic database of medical publications “PubMed”. The analysis of hedging strategies is important to eliminate possible mistakes and avoid misunderstanding in medical communication. The study of the functional implementation of hedging on the basis of certain academic genres of the English medical discourse specifies the \"doctor – patient\" communicative situation, motivates the communicative behavior of narrative figures, and optimizes international professional communication. The authors believe that paying due attention to this linguistic phenomenon within the framework of the training PhDs and academic staff will promote scientific cooperation, thus contributing to the development of higher medical education in Ukraine.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47402059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-29DOI: 10.31718/mep.2020.24.1-2.09
A. V. Lavrenko, Y. Avramenko, O. Borzykh, I. Kaidashev
Aims: Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) has various mechanisms and represents different clinical syndromes from anaphylaxis to severe bronchospasm. The prevalence of aspirin hypersensitivity among patients with asthma and nasal polyps reaches 25.6%. Respiratory reactions associated with aspirin or other NSAIDs are not immunological. The basis of these reactions is non-allergic hypersensitivity of the cross-reactive type. Desensitization followed by long-term aspirin therapy is an effective method of treating hypersensitivity to aspirin or other NSAIDs. Using aspirin 600-1200 mg/day can significantly alleviate the symptoms of asthma, allergic rhinitis. Methods: We successfully applied aspirin desensitization for method of patients with hypersensitivity to NSAIDs. According to the method, an hour before the desensitization, daily montelukast 10 mg was taken orally, then aspirin every 3 hours. Results: Three patients underwent desensitization of aspirin. The dose was selected individualy depending on the clinical manifestations of drug-induced adverse reactions (AR). ARs during desensitization were treated by iv dexamethasone administration. Subsequent doses did not cause AR. Doses of aspirin were increased to a maximum of 1250 mg daily, and were continued for the long-term use. Conclusion: It is possible to conclude that the initial dose of aspirin should be 16-40mg; it is possible to increase the dose if the initial dosage is well tolerated; symptoms of moderate intolerance are treated by 4-8 mg iv dexamethasone; prior to desensitization, we recommended to use montelukast 10 mg, it is safe to practice desensitization of aspirin according to a personalized technique by a specialist in an intensive care unit.
{"title":"ENGLISH VERSION: PERSONALIZED DESENSITIZATION WITH ACETYLSALICYLIC ACID IN PATIENTS WITH HYPERSENSITIVITY TO NON-STEROIDAL ANTI-INFLAMMATORY DRUGS","authors":"A. V. Lavrenko, Y. Avramenko, O. Borzykh, I. Kaidashev","doi":"10.31718/mep.2020.24.1-2.09","DOIUrl":"https://doi.org/10.31718/mep.2020.24.1-2.09","url":null,"abstract":"Aims: Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) has various mechanisms and represents different clinical syndromes from anaphylaxis to severe bronchospasm. The prevalence of aspirin hypersensitivity among patients with asthma and nasal polyps reaches 25.6%. Respiratory reactions associated with aspirin or other NSAIDs are not immunological. The basis of these reactions is non-allergic hypersensitivity of the cross-reactive type. Desensitization followed by long-term aspirin therapy is an effective method of treating hypersensitivity to aspirin or other NSAIDs. Using aspirin 600-1200 mg/day can significantly alleviate the symptoms of asthma, allergic rhinitis. Methods: We successfully applied aspirin desensitization for method of patients with hypersensitivity to NSAIDs. According to the method, an hour before the desensitization, daily montelukast 10 mg was taken orally, then aspirin every 3 hours. Results: Three patients underwent desensitization of aspirin. The dose was selected individualy depending on the clinical manifestations of drug-induced adverse reactions (AR). ARs during desensitization were treated by iv dexamethasone administration. Subsequent doses did not cause AR. Doses of aspirin were increased to a maximum of 1250 mg daily, and were continued for the long-term use. Conclusion: It is possible to conclude that the initial dose of aspirin should be 16-40mg; it is possible to increase the dose if the initial dosage is well tolerated; symptoms of moderate intolerance are treated by 4-8 mg iv dexamethasone; prior to desensitization, we recommended to use montelukast 10 mg, it is safe to practice desensitization of aspirin according to a personalized technique by a specialist in an intensive care unit.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48366447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-19DOI: 10.31718/MEP.2019.23.3-4.11
H. Morokhovets, Y. Lysanets, L. Ostrovska, T. Purdenko
In the contemporary academic setting, the quality of publications and the publication activity of a scientist, educational or research institution are evaluated using a set of scientific metric indicators. There are the following parameters: total citations, total number of links, the Hirsch index, impact factor, g-index, and-10 index. The aim of the paper is to cover the methods of working with the world scientific and metric databases of literature, as well as to explain the essence and algorithms for calculating the major scientific and metric indicators. We used the bibliosemantic research method in order to analyze the relevant scientific literature. The article describes the principles of mastering the tools of international databases Scopus, Web of Science, Google Scholar, Mendeley bibliographic manager, ORCID system. The paper focuses on the essence of scientific and metric indicators, calculated by these resources, as well as their scope and possibilities. The authors analyze the positive aspects of using the scientific metrics to determine the influence of a particular author or institution, as well as a number of subjective disadvantages of their widespread adoption in higher education. The modern tools for working with scientific information play a key role in the research activities of scientists, institutions of higher education, research institutions. The quality of publications is determined by a number of scientific metrics, calculated by authoritative scientific literature databases, such as Scopus and Web of Science. The h-indices are calculated in terms of publications in these bases, and serve as qualitative indicators for scientific activity evaluation. Scopus and Web of Science, in addition to their own built-in tools for searching, visualizing, analyzing and tracking data, integrated with the registers of scientists, bibliographic managers, plugins that allow to automate the processes of citation, lists of literature, preparation of publications according to the requirements of a specific edition, work with full-text versions of articles in different formats.
在当代学术环境中，出版物的质量和科学家、教育或研究机构的出版活动是用一套科学度量指标来评估的。参数有:总引用数、总链接数、赫希指数、影响因子、g指数和10指数。本文的目的是涵盖与世界科学和度量文献数据库的工作方法，以及解释计算主要科学和度量指标的本质和算法。运用文献语义学研究方法对相关科学文献进行分析。本文阐述了掌握国际数据库Scopus、Web of Science、谷歌Scholar、Mendeley bibliographic manager、ORCID系统等工具的原则。本文着重讨论了利用这些资源计算的科学指标和计量指标的本质，以及它们的范围和可能性。作者分析了使用科学指标来确定特定作者或机构的影响力的积极方面，以及在高等教育中广泛采用这些指标的一些主观缺点。处理科学信息的现代工具在科学家、高等教育机构、研究机构的研究活动中起着关键作用。出版物的质量是由一些科学指标决定的，这些指标是由权威的科学文献数据库计算出来的，比如Scopus和Web of Science。h指数是根据这些基地的出版物计算的，作为科学活动评价的定性指标。Scopus和Web of Science，除了它们自己内置的搜索、可视化、分析和跟踪数据的工具外，还集成了科学家注册、书目管理器、允许自动引用过程的插件、文献列表、根据特定版本的要求准备出版物，以及不同格式的文章全文版本。
{"title":"MASTERING THE TOOLS OF CITATION DATABASES IN HIGHER MEDICAL EDUCATION","authors":"H. Morokhovets, Y. Lysanets, L. Ostrovska, T. Purdenko","doi":"10.31718/MEP.2019.23.3-4.11","DOIUrl":"https://doi.org/10.31718/MEP.2019.23.3-4.11","url":null,"abstract":"In the contemporary academic setting, the quality of publications and the publication activity of a scientist, educational or research institution are evaluated using a set of scientific metric indicators. There are the following parameters: total citations, total number of links, the Hirsch index, impact factor, g-index, and-10 index. The aim of the paper is to cover the methods of working with the world scientific and metric databases of literature, as well as to explain the essence and algorithms for calculating the major scientific and metric indicators. We used the bibliosemantic research method in order to analyze the relevant scientific literature. The article describes the principles of mastering the tools of international databases Scopus, Web of Science, Google Scholar, Mendeley bibliographic manager, ORCID system. The paper focuses on the essence of scientific and metric indicators, calculated by these resources, as well as their scope and possibilities. The authors analyze the positive aspects of using the scientific metrics to determine the influence of a particular author or institution, as well as a number of subjective disadvantages of their widespread adoption in higher education. The modern tools for working with scientific information play a key role in the research activities of scientists, institutions of higher education, research institutions. The quality of publications is determined by a number of scientific metrics, calculated by authoritative scientific literature databases, such as Scopus and Web of Science. The h-indices are calculated in terms of publications in these bases, and serve as qualitative indicators for scientific activity evaluation. Scopus and Web of Science, in addition to their own built-in tools for searching, visualizing, analyzing and tracking data, integrated with the registers of scientists, bibliographic managers, plugins that allow to automate the processes of citation, lists of literature, preparation of publications according to the requirements of a specific edition, work with full-text versions of articles in different formats.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47466484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-19DOI: 10.31718/MEP.2019.23.3-4.02
D. Avetikov, I. Yatsenko, V. N. Нavryliev, V. V. Aipert
Today, odontogenic sinusitis (OS) occurs in up to 40% of cases among all maxillary sinusitis. At the same time there is an increase in the incidence of OS. This is facilitated by factors such as late medical treatment, improved diagnostic capabilities, an increase in number of dental and especially implantation interventions with the lifting of mucous floor of maxillary sinus. The aim of work was to develop an optimal, sparing surgical option that should lead to a lasting recovery of patients with odontogenic sinusitis. For 5 years, under supervision and treatment, there were 58 patients with hypertension from the age of 20 to 65 years. In 42 of them, the cause of development of exhaust gas was a complication of the tooth extraction operation, which led to perforation of the lower wall of the sinus. In one case out of 42 observed patients with odontogenic sinusitis (OS), the patient did not need to undergo radical surgery on the maxillary sinus lesions. All patients managed to achieve a sustained recovery with minimal surgical intervention, both in bone structures, and in the mucous membrane of the maxillary sinus (MS), nasal cavity and oral cavity. The authors of the article believe that at in case of OS, there is no evidence for radical surgery on MS, and surgical intervention should be organ-preserving. An exception can be made only for cases of OS that is complicated by inflammatory osteomyelitis, orbital and intracranial complications. Patients with OS should be treated in maxillo-facial departments with obligatory consultation of the otorhinolaryngologist, who knows the features of pathological process in MS better than the maxillofacial surgeon. In addition, in OS one should use a set of conservative measures that will help to ensure the compete treatment of the inflamed sinus. Having the opportunity to choose the optimal sparing variant of intervention, one can achieve optimal and steady recovery of patients with OS.
{"title":"MINIMALLY INVASIVE METHODOLOGY FOR SURGICAL TREATMENT OF ODONTOGENIC SINUSITIS","authors":"D. Avetikov, I. Yatsenko, V. N. Нavryliev, V. V. Aipert","doi":"10.31718/MEP.2019.23.3-4.02","DOIUrl":"https://doi.org/10.31718/MEP.2019.23.3-4.02","url":null,"abstract":"Today, odontogenic sinusitis (OS) occurs in up to 40% of cases among all maxillary sinusitis. At the same time there is an increase in the incidence of OS. This is facilitated by factors such as late medical treatment, improved diagnostic capabilities, an increase in number of dental and especially implantation interventions with the lifting of mucous floor of maxillary sinus. The aim of work was to develop an optimal, sparing surgical option that should lead to a lasting recovery of patients with odontogenic sinusitis. For 5 years, under supervision and treatment, there were 58 patients with hypertension from the age of 20 to 65 years. In 42 of them, the cause of development of exhaust gas was a complication of the tooth extraction operation, which led to perforation of the lower wall of the sinus. In one case out of 42 observed patients with odontogenic sinusitis (OS), the patient did not need to undergo radical surgery on the maxillary sinus lesions. All patients managed to achieve a sustained recovery with minimal surgical intervention, both in bone structures, and in the mucous membrane of the maxillary sinus (MS), nasal cavity and oral cavity. The authors of the article believe that at in case of OS, there is no evidence for radical surgery on MS, and surgical intervention should be organ-preserving. An exception can be made only for cases of OS that is complicated by inflammatory osteomyelitis, orbital and intracranial complications. Patients with OS should be treated in maxillo-facial departments with obligatory consultation of the otorhinolaryngologist, who knows the features of pathological process in MS better than the maxillofacial surgeon. In addition, in OS one should use a set of conservative measures that will help to ensure the compete treatment of the inflamed sinus. Having the opportunity to choose the optimal sparing variant of intervention, one can achieve optimal and steady recovery of patients with OS.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69749375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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