Pub Date : 2018-12-26DOI: 10.31718/MEP.2018.22.5-6.05
Yu. Bahmut, O. S. Ivanov, G. V. Tsapko
The hematopoietic system is a population of many cells that perform certain functions in the body. The pharmaceutical industry creates new drugs from the group of nonsteroidal anti-inflammatory drugs, but the “gold” standard remains the drug Diclofenac Sodium. In some conditions, a person is forced to take the drug for a long time, and sometimes all life. The mechanism of the drug effect on the bone marrow cells under the condition of long-term administration remains unclear. In the process of analyzing the literature, it has been established that the use of the drug has a toxic effect on the blood cells and blood-forming organs. Gradually, the toxic effect is reduced, but the long-term effect of the drug on the rat organism contributes to the inhibition of the development of erythrocyte and myelocytic sprouts of the bone marrow. A period of up to 10 days is optimal for use, and then it is worthwhile to look for a drug that is safer for the body.
{"title":"EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW","authors":"Yu. Bahmut, O. S. Ivanov, G. V. Tsapko","doi":"10.31718/MEP.2018.22.5-6.05","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.5-6.05","url":null,"abstract":"The hematopoietic system is a population of many cells that perform certain functions in the body. The pharmaceutical industry creates new drugs from the group of nonsteroidal anti-inflammatory drugs, but the “gold” standard remains the drug Diclofenac Sodium. In some conditions, a person is forced to take the drug for a long time, and sometimes all life. The mechanism of the drug effect on the bone marrow cells under the condition of long-term administration remains unclear. In the process of analyzing the literature, it has been established that the use of the drug has a toxic effect on the blood cells and blood-forming organs. Gradually, the toxic effect is reduced, but the long-term effect of the drug on the rat organism contributes to the inhibition of the development of erythrocyte and myelocytic sprouts of the bone marrow. A period of up to 10 days is optimal for use, and then it is worthwhile to look for a drug that is safer for the body.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49327719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-26DOI: 10.31718/MEP.2018.22.5-6.07
V. Prymachenko
The article analyzes current scientific literature about the most widespread and the most urgent medical problem of the present day, i.e., obesity. With the growth of the body mass index (BMI) and the occurrence of pathological (morbid) obesity in the human body, pathological modifications are detected in all systems and organs of the body. Obesity is an important independent health problem that is included into the WHO international diseases classification as a chronic disease and requires the study of pathological processes in all organs and systems of the human body.
{"title":"ENGLISH VERSION: OBESITY AS A TOPICAL MEDICAL PROBLEM OF THE 21ST CENTURY: A MODERN VIEW ON THE DISEASE OF THE HUMANITY","authors":"V. Prymachenko","doi":"10.31718/MEP.2018.22.5-6.07","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.5-6.07","url":null,"abstract":"The article analyzes current scientific literature about the most widespread and the most urgent medical problem of the present day, i.e., obesity. With the growth of the body mass index (BMI) and the occurrence of pathological (morbid) obesity in the human body, pathological modifications are detected in all systems and organs of the body. Obesity is an important independent health problem that is included into the WHO international diseases classification as a chronic disease and requires the study of pathological processes in all organs and systems of the human body.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47771025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-26DOI: 10.31718/mep.2018.22.5-6.01
N. Horbal, K. E. Ishcheykin, G. Potemkina, I. Gaiduchok, I. Kril, V. Chopyak
This article presents the results of the investigation of IFN-α synthesis dynamics on local and general levels in patients with the recurrent simple herpesvirus infection. The influence of different types of antiviral therapy to IFN-α level is estimated as well. The normalization of IFN-α level was noted in the group of patients with simple herpesvirus infection after applying of antiviral therapy and three months after the treatment, especially in the group of patients with mild course of HSV 1/2 infection, that proves the antiviral defence stabilization. Moreover, the clinical efficacy of the proposed treatment was established for patients with the recurrent HSV 1/2 infection: in the group of patients with the mild course of HSV 1/2 infection it was 73.5% after the treatment and 85.8% in the remote period; in the group of patients with the mild and severe course of HSV 1/2 infection it was 64.0% after the treatment and 70.4% in the remote period.
{"title":"THE IFN-Α SYNTHESIS MONITORING ON LOCAL AND GENERAL LEVELS IN PATIENTS WITH HERPES SIMPLEX VIRUS INFECTION","authors":"N. Horbal, K. E. Ishcheykin, G. Potemkina, I. Gaiduchok, I. Kril, V. Chopyak","doi":"10.31718/mep.2018.22.5-6.01","DOIUrl":"https://doi.org/10.31718/mep.2018.22.5-6.01","url":null,"abstract":"This article presents the results of the investigation of IFN-α synthesis dynamics on local and general levels in patients with the recurrent simple herpesvirus infection. The influence of different types of antiviral therapy to IFN-α level is estimated as well. The normalization of IFN-α level was noted in the group of patients with simple herpesvirus infection after applying of antiviral therapy and three months after the treatment, especially in the group of patients with mild course of HSV 1/2 infection, that proves the antiviral defence stabilization. Moreover, the clinical efficacy of the proposed treatment was established for patients with the recurrent HSV 1/2 infection: in the group of patients with the mild course of HSV 1/2 infection it was 73.5% after the treatment and 85.8% in the remote period; in the group of patients with the mild and severe course of HSV 1/2 infection it was 64.0% after the treatment and 70.4% in the remote period.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44477744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-26DOI: 10.31718/MEP.2018.22.5-6.02
I. Y. Bahmut, O. Halmyz, S. Hramatiuk, A. Titkova
Taking into account the importance of platelets in the mechanisms of inflammation and the autoimmune process, the aim of this study was to experimentally answer a simple question: whether platelets in people with autoimmune euthyroidism, hyperthyroidism and hypothyroidism exhibit the characteristics of high activity. The study included 35 patients with autoimmune thyroid gland disease, positive for both TRO-Ab and Tg-Ab, and with elevated TTH, and 50 patients with elevated T4 and / or T3 concentrations and depressed levels of TTH, presence of TSHR antibodies, and / or anti-microsomal antibodies. As a result of this study, it was found that ADP-induced aggregation, that is, its parameters depend on the concentration of the aggregation inductor. According to the results of our study, we hypothesized that PMPs can interact with circulating autoantibodies and C1q involved in the formation of immune complexes, which can be a pathophysiological cause of the immune response.
{"title":"PATHOGENETIC ROLE OF THROMBOCYTES IN THE DEVELOPMENT OF AUTOIMMUNE PATHOLOGY OF THE THYROID GLAND","authors":"I. Y. Bahmut, O. Halmyz, S. Hramatiuk, A. Titkova","doi":"10.31718/MEP.2018.22.5-6.02","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.5-6.02","url":null,"abstract":"Taking into account the importance of platelets in the mechanisms of inflammation and the autoimmune process, the aim of this study was to experimentally answer a simple question: whether platelets in people with autoimmune euthyroidism, hyperthyroidism and hypothyroidism exhibit the characteristics of high activity. The study included 35 patients with autoimmune thyroid gland disease, positive for both TRO-Ab and Tg-Ab, and with elevated TTH, and 50 patients with elevated T4 and / or T3 concentrations and depressed levels of TTH, presence of TSHR antibodies, and / or anti-microsomal antibodies. As a result of this study, it was found that ADP-induced aggregation, that is, its parameters depend on the concentration of the aggregation inductor. According to the results of our study, we hypothesized that PMPs can interact with circulating autoantibodies and C1q involved in the formation of immune complexes, which can be a pathophysiological cause of the immune response.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48736827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-30DOI: 10.31718/mep.2018.22.3-4.05
H. Morokhovets, Y. Lysanets
Higher medical education is a prerequisite of the present, requiring re-consideration of teaching methods and forms, as well as principles and approaches in accordance with the latest advances in science and technology. The priority direction in the transformation of higher medical education is training the competent specialists, capable of responding to the challenges of time, ready for self-improvement and continuous development. Training of specialists at the third educational and scientific level of higher education today requires forms and methods of training, aimed at the practical use of the knowledge gained.
{"title":"METHODS OF EFFECTIVE TEACHING BIOINFORMATICS IN MEDICAL ACADEMIC SETTING","authors":"H. Morokhovets, Y. Lysanets","doi":"10.31718/mep.2018.22.3-4.05","DOIUrl":"https://doi.org/10.31718/mep.2018.22.3-4.05","url":null,"abstract":"Higher medical education is a prerequisite of the present, requiring re-consideration of teaching methods and forms, as well as principles and approaches in accordance with the latest advances in science and technology. The priority direction in the transformation of higher medical education is training the competent specialists, capable of responding to the challenges of time, ready for self-improvement and continuous development. Training of specialists at the third educational and scientific level of higher education today requires forms and methods of training, aimed at the practical use of the knowledge gained.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41539786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-30DOI: 10.31718/MEP.2018.22.3-4.04
V. M. Nedoborenko, O. Shlykova, O. Izmailova, K. Ishcheikin, I. Kaidashev
Prerequisites and objective: Abdominal obesity is a common metabolic disease characterized by excessive accumulation of white adipose tissue, with excessive production of inflammatory mediators that activate transcriptional nuclear factors, in particular the nuclear factor kB. Hepcidin is the main hormone in the systemic regulation of iron. Its expression increases with elevated level of pro-inflammatory cytokines, as a result of which the concentration of iron in the blood plasma decreases, which reliably results in the activation of NF-kB. Therefore, the aim of the research was to determine the level of expression of ІКβα in subcutaneous adipose tissue in iron deficiency anemia concurrent with obesity. Methods: The study included 40 female women. Hemogram parameters, parameters of iron metabolism (serum iron, ferritin, hepcidin, total iron binding ability of serum, saturation of transferrin by iron) in serum and level of expression of the IkBα gene in subcutaneous adipose tissue were evaluated. Research results. The examined women had an average age of 40.3 ± 7.59 years. In the distribution of patients due to the cause and degree of severity of IDA, there was no reliable difference between the groups. The control group consisted of 10 obese women without IDA. Expression of IkBα by subcutaneous adipose tissue in female patients with IDA with and without obesity compared with the control group did not display a significant difference between the groups (p <0.05). In the course of correlation analysis, the expression of IkBα by subcutaneous adipose tissue to BMI, iron and hemogram rates did not have a correlated significance. Conclusion. Subcutaneous adipose tissue in women with iron deficiency anemia with and without obesity compared with obese women has no difference in expression of IkBα.
{"title":"SUBCUTANEOUS ADIPOSE TISSUE IN FEMALE PATIENTS WITH IRON DEFICIENCY ANEMIA AND OBESE WOMEN DOES NOT DIFFER IN THE EXPRESSION OF IKBΑ*","authors":"V. M. Nedoborenko, O. Shlykova, O. Izmailova, K. Ishcheikin, I. Kaidashev","doi":"10.31718/MEP.2018.22.3-4.04","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.3-4.04","url":null,"abstract":"Prerequisites and objective: Abdominal obesity is a common metabolic disease characterized by excessive accumulation of white adipose tissue, with excessive production of inflammatory mediators that activate transcriptional nuclear factors, in particular the nuclear factor kB. Hepcidin is the main hormone in the systemic regulation of iron. Its expression increases with elevated level of pro-inflammatory cytokines, as a result of which the concentration of iron in the blood plasma decreases, which reliably results in the activation of NF-kB. Therefore, the aim of the research was to determine the level of expression of ІКβα in subcutaneous adipose tissue in iron deficiency anemia concurrent with obesity. Methods: The study included 40 female women. Hemogram parameters, parameters of iron metabolism (serum iron, ferritin, hepcidin, total iron binding ability of serum, saturation of transferrin by iron) in serum and level of expression of the IkBα gene in subcutaneous adipose tissue were evaluated. Research results. The examined women had an average age of 40.3 ± 7.59 years. In the distribution of patients due to the cause and degree of severity of IDA, there was no reliable difference between the groups. The control group consisted of 10 obese women without IDA. Expression of IkBα by subcutaneous adipose tissue in female patients with IDA with and without obesity compared with the control group did not display a significant difference between the groups (p <0.05). In the course of correlation analysis, the expression of IkBα by subcutaneous adipose tissue to BMI, iron and hemogram rates did not have a correlated significance. Conclusion. Subcutaneous adipose tissue in women with iron deficiency anemia with and without obesity compared with obese women has no difference in expression of IkBα.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43254800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-30DOI: 10.31718/mep.2018.22.3-4.06
I. Bagmut, I. Kolisnyk, A. Titkova, Y. Rezunenko, O. Boiagina
The study was performed at the Department of Clinical Pathophysiology, Topographical Anatomy and Operative Surgery at Kharkiv Medical Academy of Postgraduate Education as a part of research project "Radiotoxins' pathochemical mechanisms and methods of early diagnostics and correction", state registration No. 0117U000589. We studied the subtoxic effect of small doses of sodium fluoride on the activity of microsomal hepatocytes on 30 Wistar rats' populations in subacute experiment. The intensity of lipid peroxidation (LPO) in liver of rats which were administered sodium fluoride orally for a long time at doses of 1/10 and 1/100 LD50, was evaluated by the content of its molecular products - diene conjugates (DC), and MDA-reagents Schiff bases. We found that oral administration of sodium fluoride to rats at doses of 1/10 and 1/100 LD50 promotes a statistically significant increase (r≤0,002) relative to the control group of animals in DC content during the entire period of observation. At a dose 1/10 LD50 we observed the most significant increase in this indicator on the 10th day of the experiment - at 265%, and at a dose 1/100 LD50 – on the 20th day an average of 234%. In rats’ liver by the action of subtoxical dose of sodium fluoride at a dose of 1/10 LD50, starting from the 20th day, we detected a gradual increase (r≤0.001) of TBA-reagents relative to control - for 27, 41, 78, 133%. Secondary end products and lipid peroxidation, which are defined under the long-term of sodium fluoride, somehow contribute to the disruption of the microstructure of hepatocytes membranes, their permeability, reduce their division, regeneration and inhibition of mitochondrial respiratory chain enzymes and microsomal monooxygenase system.
{"title":"THE DEVELOPMENT OF MEMBRANOUS PATHOLOGY OF HEPATOCYTES THE INFLUENCE OF INTOXICATION","authors":"I. Bagmut, I. Kolisnyk, A. Titkova, Y. Rezunenko, O. Boiagina","doi":"10.31718/mep.2018.22.3-4.06","DOIUrl":"https://doi.org/10.31718/mep.2018.22.3-4.06","url":null,"abstract":"The study was performed at the Department of Clinical Pathophysiology, Topographical Anatomy and Operative Surgery at Kharkiv Medical Academy of Postgraduate Education as a part of research project \"Radiotoxins' pathochemical mechanisms and methods of early diagnostics and correction\", state registration No. 0117U000589. \u0000We studied the subtoxic effect of small doses of sodium fluoride on the activity of microsomal hepatocytes on 30 Wistar rats' populations in subacute experiment. The intensity of lipid peroxidation (LPO) in liver of rats which were administered sodium fluoride orally for a long time at doses of 1/10 and 1/100 LD50, was evaluated by the content of its molecular products - diene conjugates (DC), and MDA-reagents Schiff bases. We found that oral administration of sodium fluoride to rats at doses of 1/10 and 1/100 LD50 promotes a statistically significant increase (r≤0,002) relative to the control group of animals in DC content during the entire period of observation. At a dose 1/10 LD50 we observed the most significant increase in this indicator on the 10th day of the experiment - at 265%, and at a dose 1/100 LD50 – on the 20th day an average of 234%. In rats’ liver by the action of subtoxical dose of sodium fluoride at a dose of 1/10 LD50, starting from the 20th day, we detected a gradual increase (r≤0.001) of TBA-reagents relative to control - for 27, 41, 78, 133%. Secondary end products and lipid peroxidation, which are defined under the long-term of sodium fluoride, somehow contribute to the disruption of the microstructure of hepatocytes membranes, their permeability, reduce their division, regeneration and inhibition of mitochondrial respiratory chain enzymes and microsomal monooxygenase system.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46009816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-30DOI: 10.31718/MEP.2018.22.3-4.07
Оксана Анатоліївна Шликова, Ольга Віталіївна Ізмайлова, Юлія Валеріївна Лисанець
Одним із найважливіших питань сучасної медицини є пошук методів регуляції програмованої загибелі клітин із метою розробки нових підходів до лікування, у тому числі раку та лейкемій. Гуморальна регуляція процесів апоптозу за допомогою цитокінів, гормонів, ростових факторів, пептидів посідає важливе місце серед механізмів регуляції апоптозу. Досліджено вплив природних пептидних комплексів тимусу та нирок на процеси апоптозу клітин HPB-ALL (гострий Т-клітинний лейкоз) та BJAB (лімфома Беркіта). Показано, що природні пептидні комплекси тимуса та нирок мають незначний стимулюючий вплив на апоптоз пухлинних В-клітин лінії BJAB у низьких концентраціях, а при збільшенні дози пептидів не впливають на процеси апоптозу; вірогідно підсилюють процеси елімінації трансформованих Т-клітин шляхом активації в них процесів апоптозу. При дії природного пептидного комплексу тимусу цей ефект має дозозалежний характер – зростає при збільшенні дози.
{"title":"ПРИРОДНІ ПЕПТИДНІ КОМПЛЕКСИ ТИМУСА ТА НИРОК ПІДСИЛЮЮТЬ АПОПТОЗ ТРАНСФОРМОВАНИХ Т-КЛІТИН, АЛЕ НЕ ВПЛИВАЮТЬ НА ПРОЦЕСИ АПОПТОЗУ В-КЛІТИН","authors":"Оксана Анатоліївна Шликова, Ольга Віталіївна Ізмайлова, Юлія Валеріївна Лисанець","doi":"10.31718/MEP.2018.22.3-4.07","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.3-4.07","url":null,"abstract":"Одним із найважливіших питань сучасної медицини є пошук методів регуляції програмованої загибелі клітин із метою розробки нових підходів до лікування, у тому числі раку та лейкемій. Гуморальна регуляція процесів апоптозу за допомогою цитокінів, гормонів, ростових факторів, пептидів посідає важливе місце серед механізмів регуляції апоптозу. Досліджено вплив природних пептидних комплексів тимусу та нирок на процеси апоптозу клітин HPB-ALL (гострий Т-клітинний лейкоз) та BJAB (лімфома Беркіта). Показано, що природні пептидні комплекси тимуса та нирок мають незначний стимулюючий вплив на апоптоз пухлинних В-клітин лінії BJAB у низьких концентраціях, а при збільшенні дози пептидів не впливають на процеси апоптозу; вірогідно підсилюють процеси елімінації трансформованих Т-клітин шляхом активації в них процесів апоптозу. При дії природного пептидного комплексу тимусу цей ефект має дозозалежний характер – зростає при збільшенні дози.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46037765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-30DOI: 10.31718/MEP.2018.22.3-4.03
A. V. Lavrenko, I. Kaidashev
This article is a part of research project of Ukrainian Medical Stomatological Academy “The Study of the Prevalence of Hypersensitivity to β-Lactam Antibiotics among the Ukrainian Population”, state registration No. 0116U004377. Allergic reactions to β-lactam antibiotics are the most common cause of adverse drug reactions, mediated by specific immunological mechanisms. The aim of this research was to determine the prevalence of hypersensitivity to β-lactam antibiotics among the population, by examining anamnestic data and conducting allergological examination to increase the safety of antibiotic therapy and improve the pharmacoeconomic profile of treatment.
{"title":"THE STUDY OF PREVALENCE OF HYPERSENSITIVITY TO Β-LACTAM ANTIBIOTICS AMONG THE POPULATION OF UKRAINE","authors":"A. V. Lavrenko, I. Kaidashev","doi":"10.31718/MEP.2018.22.3-4.03","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.3-4.03","url":null,"abstract":"This article is a part of research project of Ukrainian Medical Stomatological Academy “The Study of the Prevalence of Hypersensitivity to β-Lactam Antibiotics among the Ukrainian Population”, state registration No. 0116U004377. \u0000Allergic reactions to β-lactam antibiotics are the most common cause of adverse drug reactions, mediated by specific immunological mechanisms. The aim of this research was to determine the prevalence of hypersensitivity to β-lactam antibiotics among the population, by examining anamnestic data and conducting allergological examination to increase the safety of antibiotic therapy and improve the pharmacoeconomic profile of treatment.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49615169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-30DOI: 10.31718/mep.2018.22.3-4.02
Анна Владимировна Лавренко, Игорь Петрович Кайдашев
Данная работа является фрагментом НИР Украинской медицинской стоматологической академии «Изучение распространенности гиперчувствительности к β-лактамным антибиотикам среди населения Украины», номер госрегистрации 0116U004377.
这份工作是乌克兰牙科保健学院nar的一部分，该研究所编号为0116U004377。
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