Pub Date : 2019-04-12DOI: 10.31718/MEP.2019.23.1-2.07
A. Skrypnikov, L. V. Zhyvotovska, L. Herasymenko, D. Boiko, L. Bodnar
The reduced ability or difficulty to express verbally, to name one’s own emotional states or feelings of other people, is commonly called alexithymia. Currently, studies are being conducted in which they ascertain whether alexithymia is a specific property of a person or whether it can only predispose to psychosomatic diseases, being their predictor. Some researchers believe that alexithymia itself is not a disease and is a series of characteristics characteristic of certain individuals. Alexithymia is clearly expressed in the personality structure of patients with cardiovascular diseases and represents a separate factor in this structure. In general, studies show that patients with alexithymia are hypersensitive to both internal somatic unpleasant sensations and external pain stimuli, but they cannot describe the differences between different types of pain. Alexithymia can be considered as one of the premorbid personality factors that reduce the compensatory psychological defense capabilities in lucid alcoholism. Alexithymia is found in many drug addicts. Instead of simply getting rid of painful, intolerable, or overwhelming feelings, people who abuse chemicals can use them to control affects, especially when these affects are hard to grasp, distinguish, and give them a name. At the same time, the differences in the manifestations of alexithymia in alcohol and drug addiction, including its influence on the development of addictive behavior, are not well understood. The study of alexithymia is a topical issue of modern psychiatry and narcology, which allows us to apply a personified approach to the patient and to improve modern therapeutic and rehabilitation measures.
{"title":"ALEXITHYMIA IN HEALTHY PEOPLE AND ITS ROLE IN DEVELOPMENT OF DIFFERENT DISORDERS","authors":"A. Skrypnikov, L. V. Zhyvotovska, L. Herasymenko, D. Boiko, L. Bodnar","doi":"10.31718/MEP.2019.23.1-2.07","DOIUrl":"https://doi.org/10.31718/MEP.2019.23.1-2.07","url":null,"abstract":"The reduced ability or difficulty to express verbally, to name one’s own emotional states or feelings of other people, is commonly called alexithymia. Currently, studies are being conducted in which they ascertain whether alexithymia is a specific property of a person or whether it can only predispose to psychosomatic diseases, being their predictor. Some researchers believe that alexithymia itself is not a disease and is a series of characteristics characteristic of certain individuals. Alexithymia is clearly expressed in the personality structure of patients with cardiovascular diseases and represents a separate factor in this structure. In general, studies show that patients with alexithymia are hypersensitive to both internal somatic unpleasant sensations and external pain stimuli, but they cannot describe the differences between different types of pain. Alexithymia can be considered as one of the premorbid personality factors that reduce the compensatory psychological defense capabilities in lucid alcoholism. Alexithymia is found in many drug addicts. Instead of simply getting rid of painful, intolerable, or overwhelming feelings, people who abuse chemicals can use them to control affects, especially when these affects are hard to grasp, distinguish, and give them a name. At the same time, the differences in the manifestations of alexithymia in alcohol and drug addiction, including its influence on the development of addictive behavior, are not well understood. The study of alexithymia is a topical issue of modern psychiatry and narcology, which allows us to apply a personified approach to the patient and to improve modern therapeutic and rehabilitation measures.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46770723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-12DOI: 10.31718/MEP.2019.23.1-2.03
R. Kozak, D. Korol, Руслан Васильович Козак, Дмитро Михайлович Король
The basic conditions that ensure good functional qualities and durability of prosthetic structures from the point of view of biomechanics, undoubtedly include an optimal way of fixing a partial removable prosthesis, which consists in the correct choice of the clamping system that ensures reliable fixation of the prosthesis in the given position and at the same time causing a minimum of harm supporting teeth, as well as the most rational distribution of occlusal loads transmitted to the supporting tissues, since it is these factors that determine the durability functioning dentures. The purpose of biomechanical studies is to analyze the stress-strain state of the supporting teeth of partial removable prostheses replacing the included and terminal defects of the dentition when fixing the prosthesis on the supporting teeth with the help of holding and supporting-retaining clamps. The studies were performed on a model of the mandible with overall dimensions of the cross section corresponding to some average dimensions. The first volumetric finite element model was developed to study the stress-strain state of periodontal ligaments of supporting teeth and supporting gingival tissues when the incomplete and bilaterial end defects of the dentition were replaced (1 class 1 subclass by Kennedy) of the mandible by a removable denture with fixation by retaining clamps on the canines and the first premolars. The second volumetric finite element model is designed to study the stress-strain state of periodontal ligaments of supporting teeth and supporting gum tissues when the included and two-sided end defects of the dentition of the lower jaw are replaced by a removable clasp prosthesis with fixation of support-retaining clamps on canines and first premolars with support arms of clamps from the distal sides of premolars. As a result of the studies performed, the following conclusions can be drawn: In both considered variants fixation of removable clasp prostheses loaded with maximum values of equivalent stresses in the periodontium of the supporting teeth is localized at the apex of the alveolar ridge, which indicates the transfer of the "clutching" supporting teeth of the clasp prosthesis. The maximum values f equivalent stresses in the periodontitis of the supporting teeth during fixation of the removable clasp prosthesis by the support-retaining clamps on the canines and the first premolars exceed the corresponding values of the equivalent stresses for the case of fixing the prosthesis with retention clamps by 30-140%! With an increase in gum compliance, the values of equivalent stresses in the periodontitis of the supporting teeth during fixation of the removable clasp prosthesis by the retaining clasps vary insignificantly within 25%, and an increase in the corresponding equivalent stresses with the use of support-holding clasps may be 65%. In order to ensure the maximum sparing regimen of periodontal tissues of supporting teeth and as a result - the pos
{"title":"MATHEMATICAL SUBSTANTIATION OF THE USE OF DIFFERENT TYPES OF CLAMMERS DURING THE RESTORATION OF THE DENTITION WITH DOUBLE-SIDED DISTAL DEFECTS AND THE DEFECT INCLUDED IN THE FRONTAL AREA BY REMOVABLE PROSTHETICS","authors":"R. Kozak, D. Korol, Руслан Васильович Козак, Дмитро Михайлович Король","doi":"10.31718/MEP.2019.23.1-2.03","DOIUrl":"https://doi.org/10.31718/MEP.2019.23.1-2.03","url":null,"abstract":"The basic conditions that ensure good functional qualities and durability of prosthetic structures from the point of view of biomechanics, undoubtedly include an optimal way of fixing a partial removable prosthesis, which consists in the correct choice of the clamping system that ensures reliable fixation of the prosthesis in the given position and at the same time causing a minimum of harm supporting teeth, as well as the most rational distribution of occlusal loads transmitted to the supporting tissues, since it is these factors that determine the durability functioning dentures. The purpose of biomechanical studies is to analyze the stress-strain state of the supporting teeth of partial removable prostheses replacing the included and terminal defects of the dentition when fixing the prosthesis on the supporting teeth with the help of holding and supporting-retaining clamps. The studies were performed on a model of the mandible with overall dimensions of the cross section corresponding to some average dimensions. The first volumetric finite element model was developed to study the stress-strain state of periodontal ligaments of supporting teeth and supporting gingival tissues when the incomplete and bilaterial end defects of the dentition were replaced (1 class 1 subclass by Kennedy) of the mandible by a removable denture with fixation by retaining clamps on the canines and the first premolars. The second volumetric finite element model is designed to study the stress-strain state of periodontal ligaments of supporting teeth and supporting gum tissues when the included and two-sided end defects of the dentition of the lower jaw are replaced by a removable clasp prosthesis with fixation of support-retaining clamps on canines and first premolars with support arms of clamps from the distal sides of premolars. As a result of the studies performed, the following conclusions can be drawn: In both considered variants fixation of removable clasp prostheses loaded with maximum values of equivalent stresses in the periodontium of the supporting teeth is localized at the apex of the alveolar ridge, which indicates the transfer of the \"clutching\" supporting teeth of the clasp prosthesis. The maximum values f equivalent stresses in the periodontitis of the supporting teeth during fixation of the removable clasp prosthesis by the support-retaining clamps on the canines and the first premolars exceed the corresponding values of the equivalent stresses for the case of fixing the prosthesis with retention clamps by 30-140%! With an increase in gum compliance, the values of equivalent stresses in the periodontitis of the supporting teeth during fixation of the removable clasp prosthesis by the retaining clasps vary insignificantly within 25%, and an increase in the corresponding equivalent stresses with the use of support-holding clasps may be 65%. In order to ensure the maximum sparing regimen of periodontal tissues of supporting teeth and as a result - the pos","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43160113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-12DOI: 10.31718/MEP.2019.23.1-2.04
M. Skrypnyk, T. Petrushanko, T. Kryvoruchko, K. Neporada
Obesity prevalence has significantly increased especially in young adults, which is caused by a particular lifestyle, food quality and dietary behavior. Obesity leads to development of huge array of comorbid conditions such as arterial hypertonia, heart stroke, arthritis and other diseases. We conducted standard clinical examination of oral cavity of 154 young patients (18-21 years old) – all of them were students of Ukrainian Medical Stomatological Academy. It has been determined that the majority of patients with BMI >30 kg/cm2 have aggravated family heredity, in 66,2% cases one parent of obese students had obesity and 32,43% patients have both parents with obesity that is significantly higher compared with persons with normal BMI and overweight. There was a high prevalence of periodontal diseases about 74% and carious lesions of teeth - 97.4% among young people despite the age and contingent of examined patients - medical students. In patients with BMI >30 kg/cm2 prevalence of generalized forms of gingivitis and periodontitis was by three times higher compared with individuals with normal BMI. The values of oral hygienic indexes were poor in all examined groups, but their values were slightly lower in patients with normal BMI than in those with overweight and obesity. The prevalence of inflammatory changes in gums was higher in persons with obesity: all of them had a mild degree of lesions in periodontal tissues. Inflammatory processes in the gums were the most intense in patients with the second degree of obesity. According to the results of the study, the presence of the first and the second degree of obesity should be considered as a risk factor triggering periodontal tissues diseases. For persons with BMI >30 kg/cm2 with periodontal disease measures for the secondary prevention of inflammatory and inflammatory dystrophic periodontal diseases should be carried out and in persons without periodontal disease on the background of obesity measures primary prevention should be done.
{"title":"CONDITIONS OF THE ORAL CAVITY STATUS IN YOUTH WITH ALIMENTARY-CONSTITUTIONAL FORM OF OBESITY","authors":"M. Skrypnyk, T. Petrushanko, T. Kryvoruchko, K. Neporada","doi":"10.31718/MEP.2019.23.1-2.04","DOIUrl":"https://doi.org/10.31718/MEP.2019.23.1-2.04","url":null,"abstract":"Obesity prevalence has significantly increased especially in young adults, which is caused by a particular lifestyle, food quality and dietary behavior. Obesity leads to development of huge array of comorbid conditions such as arterial hypertonia, heart stroke, arthritis and other diseases. We conducted standard clinical examination of oral cavity of 154 young patients (18-21 years old) – all of them were students of Ukrainian Medical Stomatological Academy. It has been determined that the majority of patients with BMI >30 kg/cm2 have aggravated family heredity, in 66,2% cases one parent of obese students had obesity and 32,43% patients have both parents with obesity that is significantly higher compared with persons with normal BMI and overweight. There was a high prevalence of periodontal diseases about 74% and carious lesions of teeth - 97.4% among young people despite the age and contingent of examined patients - medical students. In patients with BMI >30 kg/cm2 prevalence of generalized forms of gingivitis and periodontitis was by three times higher compared with individuals with normal BMI. The values of oral hygienic indexes were poor in all examined groups, but their values were slightly lower in patients with normal BMI than in those with overweight and obesity. The prevalence of inflammatory changes in gums was higher in persons with obesity: all of them had a mild degree of lesions in periodontal tissues. Inflammatory processes in the gums were the most intense in patients with the second degree of obesity. According to the results of the study, the presence of the first and the second degree of obesity should be considered as a risk factor triggering periodontal tissues diseases. For persons with BMI >30 kg/cm2 with periodontal disease measures for the secondary prevention of inflammatory and inflammatory dystrophic periodontal diseases should be carried out and in persons without periodontal disease on the background of obesity measures primary prevention should be done.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42961328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-12DOI: 10.31718/MEP.2019.23.1-2.05
M. A. Shundryk, I. Marchenko, I. Tkachenko, Y. Vodoriz, V. Boyko
Scientific researches suggest posture problems as a factor affecting the occurrence of occlusion anomalies as well as their complications. The surface of the tongue may reflect disorders in digestion, cardiac activity, nervous and endocrine systems. In the literature, there is data that the tongue can help in the diagnosis of many diseases, because its general appearance is in a significant relation with its anatomical features. Receptors of its mucous membrane are closely related to the central nervous, cardiovascular, endocrine and locomotor systems. Aim. The purpose of the study was to determine the correspondence between the location of the tongue median line and the degree of distortion of the vertebral column at different levels in children with scoliosis. Materials and methods. Totally 56 children (30 girls, 26 boys) aged 11-14 years were examined, with a duration of musculoskeletal disorders 1-3 years. For each participant, the oral cavity examination was performed, the position of the middle line of the tongue was determined. X-ray images of vertebral column of patients from investigated groups were analyzed. Results. In the group with 1 year duration of the disease 25.02% patients had distorted median line of the tongue, in the group with 2 years of duration of the disease - 65,52% participants had the deviation of the medial line of the tongue, in the group with 3 years of duration of the disease 86.66% of patients had the deviation of the median line of the tongue. Conclusions. This research allows us to recommend paying attention not only to the size, color, state of the papillae of the tongue, but also to the position of the middle line, whose distortion may indicate the deviation of the vertebral column in different portions. Further research is needed to detect the mechanisms of influence of the spine and the influence of skeletal muscles on muscles of the maxillofacial area, which are involved in the formation of occlusion and function of the organs of the oral cavity.
{"title":"THE CORRESPONDENCE OF THE TONGUE CENTRAL LINE DEVIATION WITH THE PATHOLOGY OF SPINAL CURVATURE","authors":"M. A. Shundryk, I. Marchenko, I. Tkachenko, Y. Vodoriz, V. Boyko","doi":"10.31718/MEP.2019.23.1-2.05","DOIUrl":"https://doi.org/10.31718/MEP.2019.23.1-2.05","url":null,"abstract":"Scientific researches suggest posture problems as a factor affecting the occurrence of occlusion anomalies as well as their complications. The surface of the tongue may reflect disorders in digestion, cardiac activity, nervous and endocrine systems. In the literature, there is data that the tongue can help in the diagnosis of many diseases, because its general appearance is in a significant relation with its anatomical features. Receptors of its mucous membrane are closely related to the central nervous, cardiovascular, endocrine and locomotor systems. Aim. The purpose of the study was to determine the correspondence between the location of the tongue median line and the degree of distortion of the vertebral column at different levels in children with scoliosis. Materials and methods. Totally 56 children (30 girls, 26 boys) aged 11-14 years were examined, with a duration of musculoskeletal disorders 1-3 years. For each participant, the oral cavity examination was performed, the position of the middle line of the tongue was determined. X-ray images of vertebral column of patients from investigated groups were analyzed. Results. In the group with 1 year duration of the disease 25.02% patients had distorted median line of the tongue, in the group with 2 years of duration of the disease - 65,52% participants had the deviation of the medial line of the tongue, in the group with 3 years of duration of the disease 86.66% of patients had the deviation of the median line of the tongue. Conclusions. This research allows us to recommend paying attention not only to the size, color, state of the papillae of the tongue, but also to the position of the middle line, whose distortion may indicate the deviation of the vertebral column in different portions. Further research is needed to detect the mechanisms of influence of the spine and the influence of skeletal muscles on muscles of the maxillofacial area, which are involved in the formation of occlusion and function of the organs of the oral cavity.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42140612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-12DOI: 10.31718/MEP.2019.23.1-2.01
A. Z. Aikian, V. Shynkevych, I. Kaidashev, Артем Завенович Айкян, Вікторія Ігорівна Шинкевич, Ігор Петрович Кайдашев
Tumor-associated macrophages (TAM) of the M2-type dominate in tumors and produce molecules, favorable for their growth, stimulating tumor growth. However, changing the M2-type for M1 can slow down or arrest this growth. For realization of the M1 / M2 modulation direction in the treatment of carcinoma / breast cancer (BC), a substantiated diagnosis and confirmation of the TAM negative prognosis is necessary. Therefore, the aim of the study was to evaluate the relation of tumor associated macrophages to the postoperative prognosis / survival of patients with 5 molecular-biological types of breast carcinoma. Materials of the study were intraoperative tissues of tumors and ipsilateral lymph nodes in radically removed mammary glands. Pathomorphological study of lymph nodes was conducted to clarify the diagnosis in relation to N0/1. The density of TAM infiltration was determined by immunohistochemical staining of CD68 and CD163 in 30 samples of five molecular biological types of breast cancer (three clinical cases of each type). Immunohistochemical (IHC) studies for the determination of TAM and M2-like macrophages were conducted using streptavidin-peroxidase method. The quantitative representation of CD68 + and CD163 + Mph is very different from patient to patient and also within one sample, which depends, in particular, on the morphological characteristics of breast cancer, studied by the biopsy. The density of infiltration by CD163 + macrophages of the BC focus negatively correlated with postoperative survival, which did not reach statistical significance, but is included in the general concept of a negative prognosis of infiltration by M2-like macrophages. Further research is needed to confirm the negative significance of the ТАМ infiltration density in the BC primary focus for postoperative prognosis. Promising is the development of differential diagnosis and approach to the treatment of breast cancer, taking into account the levels of its infiltration by subpopulations of TAM.
{"title":"ANALYSIS OF ASSOCIATION BETWEEN THE DENSITY OF INFILTRATION IN PRIMARY CARCINOMA OF THE MAMMARY GLAND BY TUMOR-ASSOCIATED MACROPHAGES AND POSTOPERATIVE PROGNOSIS","authors":"A. Z. Aikian, V. Shynkevych, I. Kaidashev, Артем Завенович Айкян, Вікторія Ігорівна Шинкевич, Ігор Петрович Кайдашев","doi":"10.31718/MEP.2019.23.1-2.01","DOIUrl":"https://doi.org/10.31718/MEP.2019.23.1-2.01","url":null,"abstract":"Tumor-associated macrophages (TAM) of the M2-type dominate in tumors and produce molecules, favorable for their growth, stimulating tumor growth. However, changing the M2-type for M1 can slow down or arrest this growth. For realization of the M1 / M2 modulation direction in the treatment of carcinoma / breast cancer (BC), a substantiated diagnosis and confirmation of the TAM negative prognosis is necessary. Therefore, the aim of the study was to evaluate the relation of tumor associated macrophages to the postoperative prognosis / survival of patients with 5 molecular-biological types of breast carcinoma. Materials of the study were intraoperative tissues of tumors and ipsilateral lymph nodes in radically removed mammary glands. Pathomorphological study of lymph nodes was conducted to clarify the diagnosis in relation to N0/1. The density of TAM infiltration was determined by immunohistochemical staining of CD68 and CD163 in 30 samples of five molecular biological types of breast cancer (three clinical cases of each type). Immunohistochemical (IHC) studies for the determination of TAM and M2-like macrophages were conducted using streptavidin-peroxidase method. The quantitative representation of CD68 + and CD163 + Mph is very different from patient to patient and also within one sample, which depends, in particular, on the morphological characteristics of breast cancer, studied by the biopsy. The density of infiltration by CD163 + macrophages of the BC focus negatively correlated with postoperative survival, which did not reach statistical significance, but is included in the general concept of a negative prognosis of infiltration by M2-like macrophages. Further research is needed to confirm the negative significance of the ТАМ infiltration density in the BC primary focus for postoperative prognosis. Promising is the development of differential diagnosis and approach to the treatment of breast cancer, taking into account the levels of its infiltration by subpopulations of TAM.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44537264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-12DOI: 10.31718/MEP.2019.23.1-2.02
I. Delva
Post-stroke fatigue (PSF) is a common and often debilitating sequela of strokes that affects more than one third of stroke patients. Recent investigations revealed etiologic and pathogenetic heterogeneity of PSF depending on the time after acute cerebrovascular event (ACE). PSF that occur during acute stroke is associated predominantly with biological factors, including stroke-inducing immune and inflammatory reactions. In particular, we found significant associations between clinical features of PSF and certain regularities of C-reactive protein (CRP) and interleukin (IL)-1β levels in blood serum during the first 3 months after ACE occurrence. Given that there is not a clearly defined etiology for PSF, there are no rationally informed interventions. Іf dysregulation of the immune response isan important contributing factor to PSF, interventions that lessen inflammation would be appropriate treatment strategies. Іt would be reasonable to consider ASA, albeit at a higher dose than is normally used for secondary stroke prevention, as a treatment for PSF. Thus, it is advisable to study effects of ASA at the anti-inflammatory dose (300 mg a day) on markers of system inflammation an don PSF clinical course during the first 3 months after ACE occurrence. Objective: to study effectiveness of ASA at the anti-inflammatory dose (300 mg a day) on PSF clinical course and ASA effects on markers of system inflammation during the first 3 months after acute cerebrovascular event (ACE) occurrence. We recruited in the study 39 in hospital patients with ischemic strokes and transient ischemic attacks (TIA) who needed to take acetylsalicylic acid (ASA). All patients had been diagnosed with PSF within the first 3 days after ACE onset. PSF was diagnosed by use of questionnaire – Fatigue Assessment Scale (FAS). We formed two groups of patients. The first group (control PSF group) consisted of 24 patients who used ASA according to «Unified clinical protocol for medical care. Ischemic stroke (emergency, primary, secondary (specialized) medical aid, medical rehabilitation)» - after excluding hemorrhagic stroke by neuroimaging it was started ASA intake in the doses of 150-300 mg a day enterally during hospital stay with subsequent intake of 75-150 mg a day (prophylactic dose) continuously after hospital discharge. The second group (ASA PSF group) had 15 patients who started to use ASA just after excluding hemorrhagic stroke in the dosage of 300 mg a day for 3 months with subsequent dose reduction to 75-150 mg a day (prophylactic dosage) continuously. Diagnosis of PSF presence/absence, measurement of PSF severity and simultaneous measurement of systemic inflammatory markers in blood serum were carried out at the certain time points after ACE onset: at the first 3 days, at 1 month and at 3 months. Concentrations of СRP, IL-1β andIL-6 in blood serum were measured by enzyme-linked immunosorbent assay. The use of ASA in the dose of 300 mg a day during 3 months in patients who h
{"title":"EFFECTIVENESS OF ACETYLSALICYLIC ACID IN CORRECTION OF POST-STROKE FATIGUE DURING ACUTE CEREBROVASCULAR EVENTS","authors":"I. Delva","doi":"10.31718/MEP.2019.23.1-2.02","DOIUrl":"https://doi.org/10.31718/MEP.2019.23.1-2.02","url":null,"abstract":"Post-stroke fatigue (PSF) is a common and often debilitating sequela of strokes that affects more than one third of stroke patients. Recent investigations revealed etiologic and pathogenetic heterogeneity of PSF depending on the time after acute cerebrovascular event (ACE). PSF that occur during acute stroke is associated predominantly with biological factors, including stroke-inducing immune and inflammatory reactions. In particular, we found significant associations between clinical features of PSF and certain regularities of C-reactive protein (CRP) and interleukin (IL)-1β levels in blood serum during the first 3 months after ACE occurrence. Given that there is not a clearly defined etiology for PSF, there are no rationally informed interventions. Іf dysregulation of the immune response isan important contributing factor to PSF, interventions that lessen inflammation would be appropriate treatment strategies. Іt would be reasonable to consider ASA, albeit at a higher dose than is normally used for secondary stroke prevention, as a treatment for PSF. Thus, it is advisable to study effects of ASA at the anti-inflammatory dose (300 mg a day) on markers of system inflammation an don PSF clinical course during the first 3 months after ACE occurrence. Objective: to study effectiveness of ASA at the anti-inflammatory dose (300 mg a day) on PSF clinical course and ASA effects on markers of system inflammation during the first 3 months after acute cerebrovascular event (ACE) occurrence. We recruited in the study 39 in hospital patients with ischemic strokes and transient ischemic attacks (TIA) who needed to take acetylsalicylic acid (ASA). All patients had been diagnosed with PSF within the first 3 days after ACE onset. PSF was diagnosed by use of questionnaire – Fatigue Assessment Scale (FAS). We formed two groups of patients. The first group (control PSF group) consisted of 24 patients who used ASA according to «Unified clinical protocol for medical care. Ischemic stroke (emergency, primary, secondary (specialized) medical aid, medical rehabilitation)» - after excluding hemorrhagic stroke by neuroimaging it was started ASA intake in the doses of 150-300 mg a day enterally during hospital stay with subsequent intake of 75-150 mg a day (prophylactic dose) continuously after hospital discharge. The second group (ASA PSF group) had 15 patients who started to use ASA just after excluding hemorrhagic stroke in the dosage of 300 mg a day for 3 months with subsequent dose reduction to 75-150 mg a day (prophylactic dosage) continuously. Diagnosis of PSF presence/absence, measurement of PSF severity and simultaneous measurement of systemic inflammatory markers in blood serum were carried out at the certain time points after ACE onset: at the first 3 days, at 1 month and at 3 months. Concentrations of СRP, IL-1β andIL-6 in blood serum were measured by enzyme-linked immunosorbent assay. The use of ASA in the dose of 300 mg a day during 3 months in patients who h","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48084443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-05DOI: 10.31718/MEP.2018.22.5-6.08
I. Kolesnyk
To assess and substantiate the structural and metabolic mechanisms underlying the formation of intoxication, we studied the state of the pool of free plasma amino acids under the influence of sodium fluoride in the context of chronic fluoride intoxication in white rats of the Wistar population, which were orally administered sodium fluoride for 1.5 months at a dose of 20 mg / kg of body mass. Evaluation of the state of protein metabolism was conducted according to the spectrum of free plasma amino acids by ion exchange chromatography on ionites. Our studies have shown a decrease in plasma concentrations of free amino acids such as alanine, a-aminobutyric acid, threonine, serine, proline, valine, lysine, and an increase in taurine, aspartic, glutamic acid, glycine, and cysteine. The dynamics of cystine, methionine, leucine, isoleucine, cystianine, tyrosine, phenylalanine, ornithine, histidine, arginine, ammonia were not disrupted as compared with the control observation group. The decrease in the protein synthesizing function and the prevalence of catabolic processes over anabolic processes was also confirmed by the inhibition of the incorporation processes of 3H-thymidine, 3H-uridine and 14C-leucine in hepatocytes and splenocytes, which once again indicates a slowdown of synthetic processes.
{"title":"PECULIARITIES OF METABOLISM OF FREE PLASMA AMINO ACIDS IN THE BLOOD OF RATS UNDER THE EXPOSURE TO SODIUM FLUORIDE","authors":"I. Kolesnyk","doi":"10.31718/MEP.2018.22.5-6.08","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.5-6.08","url":null,"abstract":"To assess and substantiate the structural and metabolic mechanisms underlying the formation of intoxication, we studied the state of the pool of free plasma amino acids under the influence of sodium fluoride in the context of chronic fluoride intoxication in white rats of the Wistar population, which were orally administered sodium fluoride for 1.5 months at a dose of 20 mg / kg of body mass. Evaluation of the state of protein metabolism was conducted according to the spectrum of free plasma amino acids by ion exchange chromatography on ionites. Our studies have shown a decrease in plasma concentrations of free amino acids such as alanine, a-aminobutyric acid, threonine, serine, proline, valine, lysine, and an increase in taurine, aspartic, glutamic acid, glycine, and cysteine. The dynamics of cystine, methionine, leucine, isoleucine, cystianine, tyrosine, phenylalanine, ornithine, histidine, arginine, ammonia were not disrupted as compared with the control observation group. The decrease in the protein synthesizing function and the prevalence of catabolic processes over anabolic processes was also confirmed by the inhibition of the incorporation processes of 3H-thymidine, 3H-uridine and 14C-leucine in hepatocytes and splenocytes, which once again indicates a slowdown of synthetic processes.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47247770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-26DOI: 10.31718/mep.2018.22.5-6.06
В. І. Примаченко
У статті проаналізовано сучасну наукову літературу щодо найпоширенішої і найактуальнішої медичної проблеми сьогодення - ожиріння. Зі зростанням індексу маси тіла (ІМТ) і виникненням патологічного (морбідного) ожиріння в організмі людини виявляються патологічні модифікації в усіх системах і органах організму. Ожиріння є важливою самостійною медичною проблемою, яка включена в міжнародну класифікацію захворювань ВООЗ як хронічна хвороба і вимагає вивчення патологічних процесів в усіх органах і системах організму людини.
{"title":"ОЖИРІННЯ ЯК АКТУАЛЬНА МЕДИЧНА ПРОБЛЕМА ХХІ СТОЛІТТЯ: СУЧАСНИЙ ПОГЛЯД НА ХВОРОБУ ЛЮДСТВА","authors":"В. І. Примаченко","doi":"10.31718/mep.2018.22.5-6.06","DOIUrl":"https://doi.org/10.31718/mep.2018.22.5-6.06","url":null,"abstract":"У статті проаналізовано сучасну наукову літературу щодо найпоширенішої і найактуальнішої медичної проблеми сьогодення - ожиріння. Зі зростанням індексу маси тіла (ІМТ) і виникненням патологічного (морбідного) ожиріння в організмі людини виявляються патологічні модифікації в усіх системах і органах організму. Ожиріння є важливою самостійною медичною проблемою, яка включена в міжнародну класифікацію захворювань ВООЗ як хронічна хвороба і вимагає вивчення патологічних процесів в усіх органах і системах організму людини.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47759264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-26DOI: 10.31718/MEP.2018.22.5-6.04
T. Popova
The article introduces findings of the study on surfactant-induced effects on the growth and maturation of rat pups, prenatally exposed to Laprol-604. The adverse influence of Laprol-604 exposure on rat fetuses was identified in the immediate postnatal period (0-3 days) and later. Laprol-604 induced neonatal mortality within the period of three days, reduced litter size, resulted in low-birth-weight of progeny and a decrease in body weight gain in rat pups. Somatic growth retardation produced by Laprol-604 persisted during postnatal period and was accompanied by a delay in integumental morphogenesis of rat pups. Closer examination revealed an impact of Laprol-604 on delayed opening of the external auditory canal, resulting in an altered sequence of craniofacial development, such as the time of eyelid opening, incisor eruption. Maternal Laprol-604 exposure adversely affected the release and erection of the pinna. In summary, Laprol-604 had dosage-dependent developmental toxicity effect on progeny of female rats exposed to Laprol-604 during gestational period.
{"title":"EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604","authors":"T. Popova","doi":"10.31718/MEP.2018.22.5-6.04","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.5-6.04","url":null,"abstract":"The article introduces findings of the study on surfactant-induced effects on the growth and maturation of rat pups, prenatally exposed to Laprol-604. The adverse influence of Laprol-604 exposure on rat fetuses was identified in the immediate postnatal period (0-3 days) and later. Laprol-604 induced neonatal mortality within the period of three days, reduced litter size, resulted in low-birth-weight of progeny and a decrease in body weight gain in rat pups. Somatic growth retardation produced by Laprol-604 persisted during postnatal period and was accompanied by a delay in integumental morphogenesis of rat pups. Closer examination revealed an impact of Laprol-604 on delayed opening of the external auditory canal, resulting in an altered sequence of craniofacial development, such as the time of eyelid opening, incisor eruption. Maternal Laprol-604 exposure adversely affected the release and erection of the pinna. In summary, Laprol-604 had dosage-dependent developmental toxicity effect on progeny of female rats exposed to Laprol-604 during gestational period.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48537939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-26DOI: 10.31718/mep.2018.22.5-6.03
D. Avetikov, O. P. Bukhanchenko, V. V. Aipert, K. Lokes
Despite the possibility of modern surgery and dermatological cosmetology, the problem of differential diagnosis of patients with keloid scars remains relevant and significant at present. As clinical practice shows, not just the presents and the size of functional or aesthetic defect in scar tissue changes are important, but also the degree of their negative influence on the process of physical, psychological and social adaptation of the patient. The aim of our study was to optimize and improve the effectiveness of treatment of facial keloid scarring by identifying the type of scarred skin of the head and neck, and using ultrasound examination. The ultrasound method of investigation was performed on 50 patients with keloid scars of the head and neck. Clinical study of the general characteristics of the scar was supplemented by an additional analysis of the structural features of the cicatricial tissues by ultrasound examination. For the purpose of comparison, intact skin was used. Analysis of ultrasonography allowed to determine the color echogenic pattern of keloid scars, which differed substantially from the dermis of intact skin. Among the echogenic signs of postoperative keloid scarring, one should point out an increase in the depth of cicatrix of the tissue in comparison with the thickness of the intact derma, an average of 8-11%, an average thickness of the epidermis is 18-26%, a clear boundary between intact skin and keloid scar is traced, which is a clear differential sign of this type of scar. Only in 7% of cases, we have visualized the border with the hypodermis in the peripheral edges of the scar, which indicates the infiltration character of the growth of the keloid and again proves its similarity with the tumor. Today, there is no universal method for differential diagnosis of various types of scars of the head and neck. Therefore, it is necessary to develop an informative and economically expedient method of diagnostics. Ultrasonography of scarring is a non-invasive survey method that can objectively, informatively and safely evaluate numerous anatomical structures, determine the type and depth of scar formation.
{"title":"ULTRASOUND STUDY OF PATIENTS WITH KELOID SCARS OF THE MAXILLOFACIAL AREA","authors":"D. Avetikov, O. P. Bukhanchenko, V. V. Aipert, K. Lokes","doi":"10.31718/mep.2018.22.5-6.03","DOIUrl":"https://doi.org/10.31718/mep.2018.22.5-6.03","url":null,"abstract":"Despite the possibility of modern surgery and dermatological cosmetology, the problem of differential diagnosis of patients with keloid scars remains relevant and significant at present. As clinical practice shows, not just the presents and the size of functional or aesthetic defect in scar tissue changes are important, but also the degree of their negative influence on the process of physical, psychological and social adaptation of the patient. The aim of our study was to optimize and improve the effectiveness of treatment of facial keloid scarring by identifying the type of scarred skin of the head and neck, and using ultrasound examination. The ultrasound method of investigation was performed on 50 patients with keloid scars of the head and neck. Clinical study of the general characteristics of the scar was supplemented by an additional analysis of the structural features of the cicatricial tissues by ultrasound examination. For the purpose of comparison, intact skin was used. Analysis of ultrasonography allowed to determine the color echogenic pattern of keloid scars, which differed substantially from the dermis of intact skin. Among the echogenic signs of postoperative keloid scarring, one should point out an increase in the depth of cicatrix of the tissue in comparison with the thickness of the intact derma, an average of 8-11%, an average thickness of the epidermis is 18-26%, a clear boundary between intact skin and keloid scar is traced, which is a clear differential sign of this type of scar. Only in 7% of cases, we have visualized the border with the hypodermis in the peripheral edges of the scar, which indicates the infiltration character of the growth of the keloid and again proves its similarity with the tumor. Today, there is no universal method for differential diagnosis of various types of scars of the head and neck. Therefore, it is necessary to develop an informative and economically expedient method of diagnostics. Ultrasonography of scarring is a non-invasive survey method that can objectively, informatively and safely evaluate numerous anatomical structures, determine the type and depth of scar formation.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46652552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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