Pub Date : 2022-10-17DOI: 10.32007/jfacmedbagdad.6431947
A. Abdulameer, Khalil I. Abid Mohammed, Mohammed H. Alosami
Abstract: Background: Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology characterized by joint inflammation and the presence of autoantibodies, mostly Anti-cyclic citrullinated peptide antibody (ACCP) which are released when the body loses its ability to distinguish between self and foreign molecules. Serum amyloid A2 (SAA2) is an acute phase protein produced in response to inflammatory conditions including RA. Objectives: To investigate the prognostic ability of SAA2 in comparison with ACCP and the prediction of disease activity and response to treatment by Methotrexate and Etanercept in Iraqi RA patients. Patients and methods: A case control study, on a total of 150 individuals; 100 patients and 50 healthy controls. The study was carried out between November 2021 to February 2022 in Baghdad Teaching Hospital. The patients were recruited according to the American College of Rheumatology 2010 criteria. The biomarkers’ levels were measured by enzyme-linked immunosorbent assay. Results: The levels of ACCP and SAA2 in RA patients were significantly higher compared to healthy controls (p<0.001), and were higher among patients with active disease than those with inactive disease, with the levels being higher in both categories than the healthy controls (p<0.00). Highly significant ACCP levels were found in patients without treatment than those who have received treatment (methotrexate or etanercept) (p<0.00). SAA2 level in patients without treatment were not significantly different from those of patients who have received methotrexate (p>0.05) but significantly from those who have received etanercept (p≤0.02). A significant positive correlation was found between ACCP and SAA2 (r=0.553, p<0.001), with the sensitivity being (72%, 97%) and the specificity being (98%, 84%) respectively. Conclusion: ACCP and SAA2 have promising prognostic ability and disease activity prediction of RA with response to treatment (Methotrexate, Etanercept).
{"title":"A Comparative Study of Serum Amyloid A2 with Anti-cyclic Citrullinated Peptide antibody in the prognosis of a Group of Rheumatoid Arthritis Patients in Iraq","authors":"A. Abdulameer, Khalil I. Abid Mohammed, Mohammed H. Alosami","doi":"10.32007/jfacmedbagdad.6431947","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6431947","url":null,"abstract":"Abstract: \u0000Background: Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology characterized by joint inflammation and the presence of autoantibodies, mostly Anti-cyclic citrullinated peptide antibody (ACCP) which are released when the body loses its ability to distinguish between self and foreign molecules. Serum amyloid A2 (SAA2) is an acute phase protein produced in response to inflammatory conditions including RA.\u0000Objectives: To investigate the prognostic ability of SAA2 in comparison with ACCP and the prediction of disease activity and response to treatment by Methotrexate and Etanercept in Iraqi RA patients. \u0000Patients and methods: A case control study, on a total of 150 individuals; 100 patients and 50 healthy controls. The study was carried out between November 2021 to February 2022 in Baghdad Teaching Hospital. The patients were recruited according to the American College of Rheumatology 2010 criteria. The biomarkers’ levels were measured by enzyme-linked immunosorbent assay.\u0000Results: The levels of ACCP and SAA2 in RA patients were significantly higher compared to healthy controls (p<0.001), and were higher among patients with active disease than those with inactive disease, with the levels being higher in both categories than the healthy controls (p<0.00). Highly significant ACCP levels were found in patients without treatment than those who have received treatment (methotrexate or etanercept) (p<0.00). SAA2 level in patients without treatment were not significantly different from those of patients who have received methotrexate (p>0.05) but significantly from those who have received etanercept (p≤0.02). A significant positive correlation was found between ACCP and SAA2 (r=0.553, p<0.001), with the sensitivity being (72%, 97%) and the specificity being (98%, 84%) respectively.\u0000Conclusion: ACCP and SAA2 have promising prognostic ability and disease activity prediction of RA with response to treatment (Methotrexate, Etanercept).\u0000 ","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47225850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.32007/jfacmedbagdad.6431949
Ameen Abdulhasan Al Alwany
Background: Echocardiography has an important role to follow up patients with Iatrogenic atrial septaldefect (IASD) and after Catheter ablation during electro-physiological study.Objectives: evaluating the impact of non-invasive Transthoracic Echocardiography (TTE) parameters(LAVI, LVEF, ASD size and E/e`) post radiofrequency ablation of left atrial arrhythmia.Patients and methods: for the evaluation of the atrial septal defect, a transthoracic echocardiography(TTE) was used in patients who underwent left atrial arrhythmia ablation, enrolled in prospective studyin the Iraqi center for cardiac diseases, in cooperation with university of Baghdad /college of medicineResults: The outcomes of the present study were assessed according to Transthoracic Echocardiographicparameters with a median period of follow up of six months post-radiofrequency procedure for eachpatient. The mean of age was (36.28±10.34 years), females were 24 (51.1%) while males were 23(48.9%), with no structured heart diseases and normal LV function with mean EF (64.68± ,5.23%) andthe mean LA diameter (35.75±,2.92mm). Iatrogenic atrial septal defects (IASDs) were detected by TTEin all patients with range from (2-5) mm with mean of (3.47±0.92). Also we noticed that patients withsmaller ASD size had higher LVEF than those who had larger ASD size with (P=0.007), while there wasno significant association between ASD size with left atrial volume index (LAVI) and E/e`.Conclusions: Non-invasive Transthoracic Echocardiography (TTE) study that was used post atrialseptostomy for monitoring the closure of residual atrial septal defect is useful and applicable. And maybe used in daily practise post atrial septostomy procedure and recommended rather than the use ofinvasive Transoesophageal Echocardiography (TEE).
{"title":"Focus Assessment of Transthoracic Echocardiography post septostomy Procedure in Patients Undergoing Ablation of Left Atrial Supraventricular Tachycardia","authors":"Ameen Abdulhasan Al Alwany","doi":"10.32007/jfacmedbagdad.6431949","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6431949","url":null,"abstract":"Background: Echocardiography has an important role to follow up patients with Iatrogenic atrial septaldefect (IASD) and after Catheter ablation during electro-physiological study.Objectives: evaluating the impact of non-invasive Transthoracic Echocardiography (TTE) parameters(LAVI, LVEF, ASD size and E/e`) post radiofrequency ablation of left atrial arrhythmia.Patients and methods: for the evaluation of the atrial septal defect, a transthoracic echocardiography(TTE) was used in patients who underwent left atrial arrhythmia ablation, enrolled in prospective studyin the Iraqi center for cardiac diseases, in cooperation with university of Baghdad /college of medicineResults: The outcomes of the present study were assessed according to Transthoracic Echocardiographicparameters with a median period of follow up of six months post-radiofrequency procedure for eachpatient. The mean of age was (36.28±10.34 years), females were 24 (51.1%) while males were 23(48.9%), with no structured heart diseases and normal LV function with mean EF (64.68± ,5.23%) andthe mean LA diameter (35.75±,2.92mm). Iatrogenic atrial septal defects (IASDs) were detected by TTEin all patients with range from (2-5) mm with mean of (3.47±0.92). Also we noticed that patients withsmaller ASD size had higher LVEF than those who had larger ASD size with (P=0.007), while there wasno significant association between ASD size with left atrial volume index (LAVI) and E/e`.Conclusions: Non-invasive Transthoracic Echocardiography (TTE) study that was used post atrialseptostomy for monitoring the closure of residual atrial septal defect is useful and applicable. And maybe used in daily practise post atrial septostomy procedure and recommended rather than the use ofinvasive Transoesophageal Echocardiography (TEE).","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42359516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.32007/jfacmedbagdad.6431938
Fatima Sinan, Huda I. Al-Qadhi, Baraa A. Al Kareem
Background: Infertility is recognized as the incapability of infertile couples to become pregnant following one year of unsafe intercourse, with male factors accounting for roughly half of the documented instances. Several reasons for male infertility factors have been reported; however, the actual cause in the majority of cases remains unknown. Objective: To study prospectively the outcome of N-acetylcysteine on semen parameters in males with oligoasthenoteratozoospermia. Patient and methods: A total 45 patients with idiopathic oligoasthenoteratozoospermia have received N-acetyl cysteine (NAC) for 12 weeks, their seminal fluid parameters were measured at the baseline and after 12 weeks. Results: The results showed that after 3 months of NAC treatment, the motility was statistically significantly higher than pre-NAC baseline, with no statistically significant differences in both count and morphology. Conclusion: These results confirmed that NAC has a positive effect in improving motility in infertile men and thus resulting in better spermatogenesis and sperm function.
{"title":"N-acetyl cysteine’s effect on semen parameters in a sample of Iraqi men with oligoasthenoteratozoospermia","authors":"Fatima Sinan, Huda I. Al-Qadhi, Baraa A. Al Kareem","doi":"10.32007/jfacmedbagdad.6431938","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6431938","url":null,"abstract":"Background: Infertility is recognized as the incapability of infertile couples to become pregnant following one year of unsafe intercourse, with male factors accounting for roughly half of the documented instances. Several reasons for male infertility factors have been reported; however, the actual cause in the majority of cases remains unknown.\u0000Objective: To study prospectively the outcome of N-acetylcysteine on semen parameters in males with oligoasthenoteratozoospermia.\u0000Patient and methods: A total 45 patients with idiopathic oligoasthenoteratozoospermia have received N-acetyl cysteine (NAC) for 12 weeks, their seminal fluid parameters were measured at the baseline and after 12 weeks.\u0000Results: The results showed that after 3 months of NAC treatment, the motility was statistically significantly higher than pre-NAC baseline, with no statistically significant differences in both count and morphology.\u0000Conclusion: These results confirmed that NAC has a positive effect in improving motility in infertile men and thus resulting in better spermatogenesis and sperm function.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47460298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.32007/jfacmedbagdad.6431970
M. Jabarah
Background: Colorectal cancer is the third most prevalent cancer worldwide as 1.80 million new cases of the cancer were diagnosed and 862,000 patients died in 2018. Depending on the stage, upfront surgery is the main form of treatment, followed by adjuvant chemotherapy. Moreover, many drugs are approved by the U.S. Food and Drug Administration to treat Colorectal cancer including Capecitabine. However, during cancer treatment, the measurement of patient-reported symptoms experience and quality of life can provide additional information to evaluate and compare the efficacy and toxicity profiles of the treatments. Despite the importance of patients' quality of life during treatment while they are on anti-cancer treatment, there was no published data in the literature evaluating this vital parameter concerning Iraqi patients receiving anti-cancer drugs, in general, or those on Capecitabine, in particular. Therefore, the aim of current study was to evaluate quality of life of Iraqi patients with colorectal cancer treated with Capecitabine. Methods: A cross-sectional, open-label prospective study was conducted at Al-Amal and Oncology Teaching Hospitals in Baghdad during the period from November 2021 to June 2022. A convenient sampling method was adopted to enrol patients in the current study. Quality of life assessment was performed using the European Organization for Research and Treatment of Cancer quality of life questionnaire (QLQ-C30). Microsoft Excel 2019 and the Statistical Package for the Social Sciences (SPSS, Version 25) were used for data entry and analysis. The descriptive analysis focused on frequencies and percentages. Continuous variables were presented as mean (± Standard Deviation). Categorical data were presented as proportions and the Chi-squared test was used for the difference between two proportions. The level of significance was considered at P≤0.05. Results: A total of 102 patients were enrolled in the current study. Generalized fatigue was the most common adverse event as it presented in 63.7% of participants. Also, only 6.9% of participants had abnormal renal function tests. In addition, some capecitabine-treated patients had good quality of life, others did not. Conclusion: The quality of life of capecitabine-treated colorectal cancer patients seems to be sensitive to their sociodemographic characteristics and adverse effects profile of the drug.
背景:结直肠癌是全球第三大流行癌症，2018年新诊断出180万例癌症病例，86.2万例患者死亡。根据不同的阶段，术前手术是主要的治疗方式，其次是辅助化疗。此外，许多药物被美国食品和药物管理局批准用于治疗结直肠癌，包括卡培他滨。然而，在癌症治疗期间，对患者报告的症状经历和生活质量的测量可以提供额外的信息来评估和比较治疗的疗效和毒性概况。尽管患者在接受抗癌治疗期间的生活质量很重要，但文献中没有发表的数据来评估接受抗癌药物的伊拉克患者的这一重要参数，特别是那些服用卡培他滨的患者。因此，本研究的目的是评估伊拉克结直肠癌患者卡培他滨治疗后的生活质量。方法:于2021年11月至2022年6月期间在巴格达的Al-Amal和肿瘤教学医院进行了一项横断面、开放标签的前瞻性研究。本研究采用方便的抽样方法纳入患者。生活质量评估采用欧洲癌症研究与治疗组织生活质量问卷(QLQ-C30)进行。使用Microsoft Excel 2019和社会科学统计软件包(SPSS, Version 25)进行数据输入和分析。描述性分析侧重于频率和百分比。连续变量以平均值(±标准差)表示。分类资料以比例表示，两个比例之间的差异采用卡方检验。P≤0.05认为差异有显著性。结果:本研究共纳入102例患者。全身性疲劳是最常见的不良事件，出现在63.7%的参与者中。此外，只有6.9%的参与者肾功能检查异常。此外，一些卡培他滨治疗的患者有良好的生活质量，而另一些则没有。结论:卡培他滨治疗的结直肠癌患者的生活质量似乎与他们的社会人口学特征和药物的不良反应特征有关。
{"title":"Quality of life in capecitabine-treated patients with colorectal cancer is affected by their sociodemographic characteristics and their experience of the drug-related adverse effects","authors":"M. Jabarah","doi":"10.32007/jfacmedbagdad.6431970","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6431970","url":null,"abstract":"Background: Colorectal cancer is the third most prevalent cancer worldwide as 1.80 million new cases of the cancer were diagnosed and 862,000 patients died in 2018. Depending on the stage, upfront surgery is the main form of treatment, followed by adjuvant chemotherapy. Moreover, many drugs are approved by the U.S. Food and Drug Administration to treat Colorectal cancer including Capecitabine. However, during cancer treatment, the measurement of patient-reported symptoms experience and quality of life can provide additional information to evaluate and compare the efficacy and toxicity profiles of the treatments. Despite the importance of patients' quality of life during treatment while they are on anti-cancer treatment, there was no published data in the literature evaluating this vital parameter concerning Iraqi patients receiving anti-cancer drugs, in general, or those on Capecitabine, in particular. Therefore, the aim of current study was to evaluate quality of life of Iraqi patients with colorectal cancer treated with Capecitabine. Methods: A cross-sectional, open-label prospective study was conducted at Al-Amal and Oncology Teaching Hospitals in Baghdad during the period from November 2021 to June 2022. A convenient sampling method was adopted to enrol patients in the current study. Quality of life assessment was performed using the European Organization for Research and Treatment of Cancer quality of life questionnaire (QLQ-C30). Microsoft Excel 2019 and the Statistical Package for the Social Sciences (SPSS, Version 25) were used for data entry and analysis. The descriptive analysis focused on frequencies and percentages. Continuous variables were presented as mean (± Standard Deviation). Categorical data were presented as proportions and the Chi-squared test was used for the difference between two proportions. The level of significance was considered at P≤0.05.\u0000Results: A total of 102 patients were enrolled in the current study. Generalized fatigue was the most common adverse event as it presented in 63.7% of participants. Also, only 6.9% of participants had abnormal renal function tests. In addition, some capecitabine-treated patients had good quality of life, others did not.\u0000Conclusion: The quality of life of capecitabine-treated colorectal cancer patients seems to be sensitive to their sociodemographic characteristics and adverse effects profile of the drug.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69419714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.32007/jfacmedbagdad.6431935
Nada Abdul Wahhab Mousa, Muna A, Khaleefah, H. J. Al-Badri
Background: Hypertension is a chronic illness that affects one billion people both in high and low-income countries and is the most common risk factor for death throughout the world. It is also responsible for stroke, ischemic heart disease, heart, and kidney failure in addition to its huge effect on the economy. Like many developing countries, Iraq is undergoing a transitional epidemiological period with increasing burden of hypertension and its contributing risk factors e.g. unhealthy diet, physical inactivity, obesity, hyperglycemias, hypercholesterolemia, and smoking. In spite of the availability of a screening program for the early detection of hypertension in primary health care centres (PHCCs) little data on hypertension control is available. Objectives: Assessing blood pressure control rate among Iraqi adults 18 years and older, and identifying the related determinants. Patients and Methods: The study is derived from the second round of Non-Communicable Diseases Risk Factors STEPS survey Iraq 2016. A cross-sectional survey was performed on households from all Iraqi governorates excluding three governorates suffering instability. A Multi-stage cluster sampling technique for a sample of 4120 Iraqi adults was used. Interviews were held from the first week of November for 20 days using Arabic and Kurdish translated versions of STEPS questionnaire. A total of 4071 residents participated. Results: the prevalence of hypertension/ high blood pressure was 35.6%. Only 7.9% were under medication and controlled with an evident sex-based difference in favour of women (9.3% vs. 6.6% respectively). Uncontrolled blood pressure increased with age (t=7.4 p=<0.001), and declined with years of education (t= -3.3 p=0.01). It was significant among subjects with hyper-triglycerides (X²= 4.07 p= 0.044), consumption of salty processed food (X²= 7.35 p= 0.007). Blood pressure was not controlled among those reported being currently on medication (X²= 22.4 p= < 0.001). Conclusions: Blood pressure control rate is low among Iraqi adults on medical and lifestyle management. Further assessment and strengthening of clinical practice on hypertension management is recommended.
{"title":"Hypertension Control among Adult Iraqis","authors":"Nada Abdul Wahhab Mousa, Muna A, Khaleefah, H. J. Al-Badri","doi":"10.32007/jfacmedbagdad.6431935","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6431935","url":null,"abstract":"Background: Hypertension is a chronic illness that affects one billion people both in high and low-income countries and is the most common risk factor for death throughout the world. It is also responsible for stroke, ischemic heart disease, heart, and kidney failure in addition to its huge effect on the economy. Like many developing countries, Iraq is undergoing a transitional epidemiological period with increasing burden of hypertension and its contributing risk factors e.g. unhealthy diet, physical inactivity, obesity, hyperglycemias, hypercholesterolemia, and smoking. In spite of the availability of a screening program for the early detection of hypertension in primary health care centres (PHCCs) little data on hypertension control is available.\u0000Objectives: Assessing blood pressure control rate among Iraqi adults 18 years and older, and identifying the related determinants.\u0000Patients and Methods: The study is derived from the second round of Non-Communicable Diseases Risk Factors STEPS survey Iraq 2016. A cross-sectional survey was performed on households from all Iraqi governorates excluding three governorates suffering instability. A Multi-stage cluster sampling technique for a sample of 4120 Iraqi adults was used. Interviews were held from the first week of November for 20 days using Arabic and Kurdish translated versions of STEPS questionnaire. A total of 4071 residents participated.\u0000Results: the prevalence of hypertension/ high blood pressure was 35.6%. Only 7.9% were under medication and controlled with an evident sex-based difference in favour of women (9.3% vs. 6.6% respectively). Uncontrolled blood pressure increased with age (t=7.4 p=<0.001), and declined with years of education (t= -3.3 p=0.01). It was significant among subjects with hyper-triglycerides (X²= 4.07 p= 0.044), consumption of salty processed food (X²= 7.35 p= 0.007). Blood pressure was not controlled among those reported being currently on medication (X²= 22.4 p= < 0.001).\u0000Conclusions: Blood pressure control rate is low among Iraqi adults on medical and lifestyle management. Further assessment and strengthening of clinical practice on hypertension management is recommended.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45858038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-24DOI: 10.32007/jfacmedbagdad.6421907
Janan Alrefaee, Aishah E Albalawi, S. Alanazi, Norah A Althobaiti, H. Daghash, Tharaa Abu Hasb, Mohammad S. Abusuliman
Background: On March 2020, the first case of coronavirus disease-19 was registered in the Kingdom of Saudi Arabia and subsequently the first mortality case. The predicting factors for patients' outcomes are essential to triage patients with COVID-19. This may provide low-cost facilities that help in the fight against the existing global pandemic. Objectives: This study aimed to predict hospitalization and death outcomes of COVID-19 patients using the simplest facilities. Method: The electronic medical records of 280 COVID-19 patients between March 2020 and May 2021 were retrieved from a multi-centre of healthcare facilities across Kingdom of Saudi Arabian cites. All demographic and clinical information were examined to determine predictors and outcomes. Results: Of the 280 COVID -19 patients enrolled in our study, 14.3% were aged ≥ 66 years and 62.5% were female. The elderly (≥ 66 years, P= 0.000) and male patients (P= 0.001) were significantly hospitalized by COVID -19 than others. Patients with symptoms were hospitalized significantly more than patients without symptoms (P= 0.001). Patients with chronic conditions were hospitalized more frequently (P= 0.001). Hospitalization status also did not differ by smoking. Fever occurred significantly more frequently in patients with one or more chronic diseases (P = 0.000). Elderly (≥ 66 years, P= 0.000) and male patients of COVID -19 (P= 0.022) had significant evidence of association with death outcome than others. Hospitalization status was associated with death (P = 0.000). Conclusion: This study reported that male gender and advanced age COVID-19 patients are independent predictors for both hospital admission and death outcomes more than others. The COVID-19 patients who complain from symptoms are at risk for hospitalization as well. Additionally, having chronic clinical conditions are predictor factor for hospital admission outcome. Finally, the hospitalized patients of COVID-19 infection are at risk for death outcome.
{"title":"The predicting factors of clinical outcomes in patients with COVID-19 in the Kingdom of Saudi Arabia [KSA]: A multi-center cohort study","authors":"Janan Alrefaee, Aishah E Albalawi, S. Alanazi, Norah A Althobaiti, H. Daghash, Tharaa Abu Hasb, Mohammad S. Abusuliman","doi":"10.32007/jfacmedbagdad.6421907","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6421907","url":null,"abstract":"Background: On March 2020, the first case of coronavirus disease-19 was registered in the Kingdom of Saudi Arabia and subsequently the first mortality case. The predicting factors for patients' outcomes are essential to triage patients with COVID-19. This may provide low-cost facilities that help in the fight against the existing global pandemic. \u0000Objectives: This study aimed to predict hospitalization and death outcomes of COVID-19 patients using the simplest facilities.\u0000Method: The electronic medical records of 280 COVID-19 patients between March 2020 and May 2021 were retrieved from a multi-centre of healthcare facilities across Kingdom of Saudi Arabian cites. All demographic and clinical information were examined to determine predictors and outcomes.\u0000Results: Of the 280 COVID -19 patients enrolled in our study, 14.3% were aged ≥ 66 years and 62.5% were female. The elderly (≥ 66 years, P= 0.000) and male patients (P= 0.001) were significantly hospitalized by COVID -19 than others. Patients with symptoms were hospitalized significantly more than patients without symptoms (P= 0.001). Patients with chronic conditions were hospitalized more frequently (P= 0.001). Hospitalization status also did not differ by smoking. Fever occurred significantly more frequently in patients with one or more chronic diseases (P = 0.000). Elderly (≥ 66 years, P= 0.000) and male patients of COVID -19 (P= 0.022) had significant evidence of association with death outcome than others. Hospitalization status was associated with death (P = 0.000).\u0000Conclusion: This study reported that male gender and advanced age COVID-19 patients are independent predictors for both hospital admission and death outcomes more than others. The COVID-19 patients who complain from symptoms are at risk for hospitalization as well. Additionally, having chronic clinical conditions are predictor factor for hospital admission outcome. Finally, the hospitalized patients of COVID-19 infection are at risk for death outcome.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45966302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-24DOI: 10.32007/jfacmedbagdad.6421942
E. Abed, Dr Manal K Rasheed, Dr Khalaf G.Hussein
Background: Type 2 diabetes negatively affects the biochemical parameters of bone turnover more than obesity and is associated with an increased risk of osteoporosis and fragility fractures. Obesity and type 2 diabetes (T2DM) are linked to increased fracturing risk; however, the effect of obesity on diabetes-related bone deficit is unknown. Objective: The goal of this research is to compare the indications, bone density, and bone turnover in T2DM men and a control group, and to investigate the effect of body mass index on bone turnover levels. Subjects, Material and Method: This case-control study was conducted on 120 men whose ages were from 40 - 69 years. They were grouped into two categories: T2DM (n=80) and healthy control (n=40). Serum samples from both groups were analyzed for blood glucose, Calcium and Albumin, by using (Cobas c111), PTH by (Cobas e 411), P1NP and CTX-1 levels in the serum using ELISA kits. Participants underwent (DEXA) measuring Bone Mass Density (BMD) at the lumbar spine. Results: The control (obese and non-obese) participants had statistically significant higher levels of CTX-1 and P1NP than the patients (obese and non-obese) (P-value = 0.000). There was no significant differences in Spine BMD, T-score (p-value = 0.27 and 0.37 respectively). Conclusion: Men with T2DM had a low bone turnover level and deteriorated bone quality compared to controls. The obese healthy controls can maintain healthy bone metabolism if T2DM is prevented.
{"title":"Assessment of Total Procollagen Type 1 Intact N-terminal Propeptide, C-telopeptide of type 1 collagen, Bone Mineral Density and its Relationship to Body Mass Index in Men with Type 2 Diabetes","authors":"E. Abed, Dr Manal K Rasheed, Dr Khalaf G.Hussein","doi":"10.32007/jfacmedbagdad.6421942","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6421942","url":null,"abstract":"Background: Type 2 diabetes negatively affects the biochemical parameters of bone turnover more than obesity and is associated with an increased risk of osteoporosis and fragility fractures. Obesity and type 2 diabetes (T2DM) are linked to increased fracturing risk; however, the effect of obesity on diabetes-related bone deficit is unknown.\u0000Objective: The goal of this research is to compare the indications, bone density, and bone turnover in T2DM men and a control group, and to investigate the effect of body mass index on bone turnover levels.\u0000Subjects, Material and Method: This case-control study was conducted on 120 men whose ages were from 40 - 69 years. They were grouped into two categories: T2DM (n=80) and healthy control (n=40). Serum samples from both groups were analyzed for blood glucose, Calcium and Albumin, by using (Cobas c111), PTH by (Cobas e 411), P1NP and CTX-1 levels in the serum using ELISA kits. Participants underwent (DEXA) measuring Bone Mass Density (BMD) at the lumbar spine.\u0000Results: The control (obese and non-obese) participants had statistically significant higher levels of CTX-1 and P1NP than the patients (obese and non-obese) (P-value = 0.000). There was no significant differences in Spine BMD, T-score (p-value = 0.27 and 0.37 respectively).\u0000Conclusion: Men with T2DM had a low bone turnover level and deteriorated bone quality compared to controls. The obese healthy controls can maintain healthy bone metabolism if T2DM is prevented.\u0000 ","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47610049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-24DOI: 10.32007/jfacmedbagdad.6421921
Nawras Sabah najim, Abdulnasir H. Ameer, Azad A. Mohammed
Abstract: Background: The most frequent movement issue seen in clinical practice is tremors. It is known as repetitive, involuntary oscillations. The diagnostic process for tremor patients can be time-consuming and complicated, as the identification of “Essential Tremor” and its distinction from other types of tremor. Objectives: This study aimed to describe the electrophysiological findings of essential, enhanced physiological, and physiological tremors, using surface electromyography and an accelerometer. Patients and Methods: The study included 24 patients with essential tremors, 10 patients with enhanced physiological tremors, and 10 patients with physiological tremors. We assessed the frequency, amplitude, and muscular contraction pattern of tremors during rest, posture, and a 1 kg load. Results: The tremor frequency of essential tremor patients was about 4.2-10.1 Hertz, while enhanced physiological tremor and physiological tremor were increased to 6.1–12.7 Hertz and 5.1-10.2 Hertz, respectively. The essential tremor group muscle contraction pattern was predominantly synchronous, as do all enhanced physiological, and physiological tremor patients, but with more fine low amplitude muscle bursts. By varying the tremor frequency and the weight load effect, tremor analysis could discriminate essential from enhanced physiological, and physiological tremors. Conclusions: The tremor analysis using surface electromyography and an accelerometer is sufficient to differentiate between essential tremors, enhanced physiological tremors, and physiological tremors.
{"title":"The Electrophysiological Perspectives of Essential, Enhanced Physiological, and Physiological Tremors","authors":"Nawras Sabah najim, Abdulnasir H. Ameer, Azad A. Mohammed","doi":"10.32007/jfacmedbagdad.6421921","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6421921","url":null,"abstract":"Abstract: \u0000Background: The most frequent movement issue seen in clinical practice is tremors. It is known as repetitive, involuntary oscillations. The diagnostic process for tremor patients can be time-consuming and complicated, as the identification of “Essential Tremor” and its distinction from other types of tremor.\u0000Objectives: This study aimed to describe the electrophysiological findings of essential, enhanced physiological, and physiological tremors, using surface electromyography and an accelerometer.\u0000Patients and Methods: The study included 24 patients with essential tremors, 10 patients with enhanced physiological tremors, and 10 patients with physiological tremors. We assessed the frequency, amplitude, and muscular contraction pattern of tremors during rest, posture, and a 1 kg load.\u0000 Results: The tremor frequency of essential tremor patients was about 4.2-10.1 Hertz, while enhanced physiological tremor and physiological tremor were increased to 6.1–12.7 Hertz and 5.1-10.2 Hertz, respectively. The essential tremor group muscle contraction pattern was predominantly synchronous, as do all enhanced physiological, and physiological tremor patients, but with more fine low amplitude muscle bursts. By varying the tremor frequency and the weight load effect, tremor analysis could discriminate essential from enhanced physiological, and physiological tremors.\u0000Conclusions: The tremor analysis using surface electromyography and an accelerometer is sufficient to differentiate between essential tremors, enhanced physiological tremors, and physiological tremors.\u0000 ","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48935721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-24DOI: 10.32007/jfacmedbagdad.6421925
Rand Salih, Hanan L. Al-Omary
Background: Multiple sclerosis (MS) prevalence in Iraq is 11.73/100,000 it causes disability in younger adults. Expanded Disability Status Scale (EDSS) can monitor MS disability while Visually Evoked Potentials (VEP) serves as a marker of myelination. Objectives: To explore the relationship between EDSS and VEPs in multiple sclerosis patients. Patients and Methods: A cross-sectional study was conducted in Ghazi Al- Hariri Hospital from first of Nov 2021 till the end of Jan 2022. Fifty patients with multiple sclerosis were compared to 50 healthy individuals. EDSS Data were collected using a structured questionnaire, P100 latency were measured using VEP. The Correlation was used to investigate the relationship between P100- latencies and EDSS. P value ≤0.05 was considered significant. Results: The average age of MS cases was 33.5±8.01 years, and the mean EDSS was 2.8±2.86. A significant difference in the latency period was reported. The study showed a significant positive correlation between EDSS and P100 latency period. Conclusions: Using non-invasive procedures like VEPs can help to monitor and detect deterioration and improvement in MS patients.
{"title":"Expanded disability status scale in Multiple Sclerosis: Relationship to visual evoked potential","authors":"Rand Salih, Hanan L. Al-Omary","doi":"10.32007/jfacmedbagdad.6421925","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6421925","url":null,"abstract":"Background: Multiple sclerosis (MS) prevalence in Iraq is 11.73/100,000 it causes disability in younger adults. Expanded Disability Status Scale (EDSS) can monitor MS disability while Visually Evoked Potentials (VEP) serves as a marker of myelination.\u0000Objectives: To explore the relationship between EDSS and VEPs in multiple sclerosis patients.\u0000Patients and Methods: A cross-sectional study was conducted in Ghazi Al- Hariri Hospital from first of Nov 2021 till the end of Jan 2022. Fifty patients with multiple sclerosis were compared to 50 healthy individuals. EDSS Data were collected using a structured questionnaire, P100 latency were measured using VEP. The Correlation was used to investigate the relationship between P100- latencies and EDSS. P value ≤0.05 was considered significant.\u0000Results: The average age of MS cases was 33.5±8.01 years, and the mean EDSS was 2.8±2.86. A significant difference in the latency period was reported. The study showed a significant positive correlation between EDSS and P100 latency period.\u0000Conclusions: Using non-invasive procedures like VEPs can help to monitor and detect deterioration and improvement in MS patients.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45474597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-24DOI: 10.32007/jfacmedbagdad.6421889
W. Hussen, Ahmed Noureldin Abdulkadir, Akeel S. Yuser
Background: Traumatic haemothorax is a collection of blood within the pleural cavity due to a penetrating or blunt injury leading to blood accumulation inside the pleural space with its respiratory and hemodynamic consequences. Objectives: Is to retrospectively study eighty victims of traumatic haemothorax regarding their age, gender, types of injury, and their sequel, as well as the methods of investigation, treatment modality (conservative or operative) and their outcome. Patients and methods: The data of 80 patients with traumatic haemothorax admitted to Ibn AL-Nnafees teaching hospital from (1st of August 2018 to 30th. of September 2019), was collected. The data was analyzed according to age, gender, clinical features, associated findings, mechanism of injury, imaging, procedure performed, operative finding, post-operative outcome, morbidity, mortality and follow up. Result: Seventy-four (92.5%) of our patients were males, and 32 (40%) were between 21-30 year of age. Fifty-four patients (67.5%) were injured by bullet, stab or shell injury. The remaining 26 patients (32.5%) were affected by blunt injury. Sixty patients (75%) were treated successfully with tube thoracostomy only. Eight patients (10%) required emergency thoracotomy after the insertion of chest tube, ten patients (12.5%) needed elective thoracotomy for (clotted haemothorax, foreign body extraction or empyema), and the remaining two patients (2.5%) presented with minimal haemothorax and didn’t need any intervention. Sixty-two of our patients (77.5%) were discharged well within 7 days. Those with air leak or who needed thoracotomy (elective or emergency) had longer hospitalization periods. Only one patient with empyema needed to stay more than 30 days. Sixty-nine (86.3%) of our patients were discharged well, while complication occurred in three patients (3.8%) with air leak, two (2.5%) ended with empyema and four patients (5%) with clotted haemothorax. Two patients (2.5%) died due to sever uncontrolled bleeding. Conclusion: Most of the patients with traumatic haemothorax were simply managed by tube thoracostomy only. In haemodynamically unstable patients, no time should be wasted for investigations and a resuscitative thoracotomy can save the patient’s life. Rapid assessment and early intervention will save the life of patient with traumatic haemothorax.
背景：外伤性血胸是指由于穿透性或钝性损伤导致胸膜腔内血液积聚，从而导致呼吸和血液动力学后果。目的：回顾性研究80例创伤性血胸患者的年龄、性别、损伤类型及其后遗症，以及调查方法、治疗方式（保守治疗或手术治疗）及其结果。患者和方法：收集自2018年8月1日至2019年9月30日在Ibn AL Nnafees教学医院入院的80名创伤性血胸患者的数据。根据年龄、性别、临床特征、相关发现、损伤机制、影像学、手术方法、手术发现、术后结果、发病率、死亡率和随访对数据进行分析。结果：74例（92.5%）患者为男性，32例（40%）患者年龄在21-30岁之间。54名患者（67.5%）因子弹、刺伤或炮弹受伤。其余26名患者（32.5%）受钝性损伤影响。60例（75%）患者仅通过胸腔造口术成功治疗。8名患者（10%）在插入胸管后需要紧急开胸，10名患者（12.5%）需要选择性开胸治疗（血胸凝结、异物提取或脓胸），其余2名患者（2.5%）出现最小血胸，不需要任何干预。我们的62名患者（77.5%）在7天内出院。那些有空气泄漏或需要开胸手术（选择性或紧急）的患者住院时间更长。只有一名脓胸患者需要住院30天以上。69例（86.3%）患者出院良好，3例（3.8%）患者出现并发症，2例（2.5%）患者出现脓胸，4例（5%）患者出现血胸。两名患者（2.5%）因严重未控制的出血而死亡。结论：大多数外伤性血胸患者仅采用管式胸腔造口术治疗。对于血流动力学不稳定的患者，不应浪费时间进行调查，复苏性开胸手术可以挽救患者的生命。快速评估和早期干预将挽救创伤性血胸患者的生命。
{"title":"Traumatic Haemothorax: Diagnostic approaches and surgical management","authors":"W. Hussen, Ahmed Noureldin Abdulkadir, Akeel S. Yuser","doi":"10.32007/jfacmedbagdad.6421889","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6421889","url":null,"abstract":"Background: Traumatic haemothorax is a collection of blood within the pleural cavity due to a penetrating or blunt injury leading to blood accumulation inside the pleural space with its respiratory and hemodynamic consequences.\u0000Objectives: Is to retrospectively study eighty victims of traumatic haemothorax regarding their age, gender, types of injury, and their sequel, as well as the methods of investigation, treatment modality (conservative or operative) and their outcome. \u0000Patients and methods: The data of 80 patients with traumatic haemothorax admitted to Ibn AL-Nnafees teaching hospital from (1st of August 2018 to 30th. of September 2019), was collected. The data was analyzed according to age, gender, clinical features, associated findings, mechanism of injury, imaging, procedure performed, operative finding, post-operative outcome, morbidity, mortality and follow up.\u0000Result: Seventy-four (92.5%) of our patients were males, and 32 (40%) were between 21-30 year of age. Fifty-four patients (67.5%) were injured by bullet, stab or shell injury. The remaining 26 patients (32.5%) were affected by blunt injury. Sixty patients (75%) were treated successfully with tube thoracostomy only. Eight patients (10%) required emergency thoracotomy after the insertion of chest tube, ten patients (12.5%) needed elective thoracotomy for (clotted haemothorax, foreign body extraction or empyema), and the remaining two patients (2.5%) presented with minimal haemothorax and didn’t need any intervention. Sixty-two of our patients (77.5%) were discharged well within 7 days. Those with air leak or who needed thoracotomy (elective or emergency) had longer hospitalization periods. Only one patient with empyema needed to stay more than 30 days. Sixty-nine (86.3%) of our patients were discharged well, while complication occurred in three patients (3.8%) with air leak, two (2.5%) ended with empyema and four patients (5%) with clotted haemothorax. Two patients (2.5%) died due to sever uncontrolled bleeding.\u0000Conclusion: Most of the patients with traumatic haemothorax were simply managed by tube thoracostomy only. In haemodynamically unstable patients, no time should be wasted for investigations and a resuscitative thoracotomy can save the patient’s life. Rapid assessment and early intervention will save the life of patient with traumatic haemothorax.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45550039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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