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Management of Rhegmatogenous Retinal Detachment: Tips and Tricks for The Beginners 孔源性视网膜脱离的处理:初学者的提示和技巧
Pub Date : 2019-02-28 DOI: 10.35479/IJRETINA.2019.VOL002.ISS001.69
L. Gopal
Lingam Gopal, National University Health system, Singapore, gopal_lingam@nuhs.edu.sg INTRODUCTION In the portfolio of a vitreo retinal surgical practice, management of retinal detachments occupies the premium position. The following serves as an introduction with a philosophical slant rather than as a detailed listing of the dos and don’ts. It is primarily addressed to the vitreo retinal trainee. Hence, I would like to offer an advance apology to the trained and experienced retinal surgeons who may browse through this article.
Lingam Gopal,国立大学卫生系统,新加坡,gopal_lingam@nuhs.edu.sg简介在玻璃体视网膜手术实践的投资组合中,视网膜脱离的管理占据着重要的地位。以下是带有哲学倾向的介绍,而不是详细列出该做和不该做的事情。它主要是针对玻璃体视网膜受训者的。因此,我想提前向可能浏览这篇文章的受过训练和经验丰富的视网膜外科医生道歉。
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引用次数: 0
Usher Syndrome in Two Siblings, A Case Report 两个兄弟姐妹的Usher综合征一例报告
Pub Date : 2019-02-28 DOI: 10.35479/IJRETINA.2019.VOL002.ISS001.66
Teddy Kristiyan, N. Dewi, Safaruddin Refa
Introduction: Usher Syndrome is a rare genetic disorder involving abnormalities in the retina and hearing, where the patients will experience blindness and hearing loss due to mutations of the gene. Blindness caused by Usher Syndrome has not been prevented until now, but the emphasis is more on focusing early diagnosis, especially patients with Retinitis Pigmentosa. Methods: This Case represent of two siblings with Retinitis Pigmentose (RP) and profound bilateral sensorineural deafness. Diagnosis based on patients decreases of vision since teenagers and worst at night, visual acuity and visual field examination in both patients, Ophthalmoscopic findings, and sensorineural deafness diagnosed by Ear, Nose, and Throat (ENT) department. Electroretinogram (ERG) was not carried out in the two patients because of the limitations of diagnostic facilities. Result: In both eyes of both siblings, ophthalmoscopic evaluation disclosed numerous bone spiculae at peripheral area. Humphrey perimetry showed a tunnel vision. The hearing test also showed a sensorineural hearing loss (SNHL). Conclusion: two affected member of the family were found to exhibit an usher syndrome, this pedigree supports the genetic cotransmission of the traits.
简介:Usher综合征是一种罕见的遗传性疾病,涉及视网膜和听力异常,患者会因基因突变而失明和听力丧失。Usher综合征致盲至今仍未得到预防,但更强调的是早期诊断,尤其是色素性视网膜炎患者。方法:本病例为双侧重度感音神经性耳聋合并色素性视网膜炎的兄弟姐妹。诊断依据:患者从青少年开始视力下降,夜间最严重,两例患者的视力和视野检查,眼科检查结果,耳鼻喉科诊断的感音神经性耳聋。由于诊断设备的限制,两例患者未进行视网膜电图(ERG)检查。结果:兄弟姐妹双眼镜检查均发现周围有大量骨刺。汉弗莱的视野检查显示视野狭窄。听力测试还显示感音神经性听力损失(SNHL)。结论:两名受影响的家庭成员被发现表现出usher综合征,该家系支持该性状的遗传共传。
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引用次数: 1
Surgical Technique of Late Spontaneous IOL-Capsular Bag Complex Dislocation with Low Corneal Endothelial Cell Density: A Case Report 角膜内皮细胞密度低的晚期自发性iol - capsule - Bag Complex脱位1例手术技术
Pub Date : 2019-02-28 DOI: 10.35479/IJRETINA.2019.VOL002.ISS001.54
F. S. Wardhana, D. H. Sakti, S. Supanji, M. B. Sasongko, T. W. Widayanti, A. N. Agni
Introduction: IOL-capsular bag complex dislocation is a rare but serious complication of phacoemulsification surgery. Technique to repair this complication should be based on various clinical parameters including quality of corneal endothelial cells and the type of dislocated IOL. Case Presentation: We present a case of a 67-year-old male with left eye spontaneous one-piece foldable IOL-capsular bag complex dislocation to vitreous cavity 4 years after phacoemulsification surgery.  Visual acuity of the left eye was 1/60, pupil was round with 3 mm diameter and IOP was 15 mmHg. Noncontact specular microscopy examination showed that the corneal endothelial cell density was 1100 cells/mm2. It was managed with 23-gauge posterior vitrectomy, IOL evacuation to anterior chamber, releasing the capsular bag and repositioning the IOL into posterior chamber by sutured scleral fixation. Result: Follow-up at 6thmonth, best corrected visual acuity of the left eye achieved 6/6, IOL at central position and the last corneal endothelial cell density was 1076 cells/mm2. Conclusions: Late spontaneous IOL-capsular bag complex dislocation with low corneal endothelial cell density can be safely managed with proper surgical technique. Vitrectomy and sutured scleral fixation of the previously dislocated IOL were effective in managing such case. Longer follow-up should be done to assure the stability of IOL position and the quality of corneal endothelial cells.
摘要人工晶状体囊袋复杂性脱位是超声乳化手术中一种罕见但严重的并发症。该并发症的修复技术应基于各种临床参数,包括角膜内皮细胞的质量和脱位的人工晶体的类型。病例介绍:我们报告一例67岁男性患者,在超声乳化术4年后左眼自发性单件折叠iol -囊袋复合脱位至玻璃体腔。左眼视力1/60,瞳孔圆形,直径3mm, IOP 15mmhg。非接触镜检查显示角膜内皮细胞密度为1100个细胞/mm2。术后行23号玻璃体切除术,将人工晶状体移至前房,释放囊袋,巩膜缝合固定将人工晶状体重新定位至后房。结果:随访6个月,左眼最佳矫正视力达到6/6,人工晶状体位于中心位置,最后角膜内皮细胞密度为1076细胞/mm2。结论:角膜内皮细胞密度低的晚期自发性iol - capsule - bag complex脱位可通过适当的手术技术安全治疗。玻璃体切除术和巩膜缝合固定先前脱位的人工晶状体是有效的治疗方法。为保证人工晶状体位置的稳定性和角膜内皮细胞的质量,应进行较长时间的随访。
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引用次数: 0
The Characteristics of Patient with Macular Hole After Pars Plana Vitrectomy (PPV) and Internal Limiting Membran (ILM) Peeling in Cicendo Eye Hospital National Eye Center, Bandung 万隆Cicendo眼科医院国家眼科中心玻璃体切除(PPV)及内限定膜(ILM)剥离术后黄斑裂孔的特点
Pub Date : 2019-02-28 DOI: 10.35479/IJRETINA.2019.VOL002.ISS001.61
Rani Pitta Omas
Introduction : Macular hole (MH) can cause severe visual disturbance, but remarkable progress has been achieved in surgical treatment for eyes with this condition. Vitrectomy with internal limiting membrane (ILM) peeling allows a very high success rate for MH closure (approaching 90%). To compare characteristics patients with closed and unclosed macular hole after pars plana vitrectomy (PPV) surgery and internal limiting membran (ILM) peeling. Method : This was retrospective study which data was obtain from patient’s medical records who underwent PPV and ILM peeling since July 1st to December 31th 2018. Results :  27 eyes from 25 patients had MH surgery. 20 eyes (74%)  had closed MH and 7 (26%) eyes unclosed MH after surgery. HFF value before surgery was 1,34 ± 0,90 and MHI was 1,09 ± 0,81 in closed MH. Meanwhile in unclosed MH, HFF value before surgery 0,53 ± 0,12 and MHI was 0,75 ±0,10. MHI ≥0,5 and HFF value ≥ 0,9 had a good prognostic factor. Conclusion : Despite of good prognostic factor from OCT measurement and achieve anatomical success,  foveal microstructure also important in  visual recovery after MH surgery.
黄斑裂孔(MH)可引起严重的视力障碍,但手术治疗黄斑裂孔已取得显著进展。玻璃体切除术配合内限制膜(ILM)剥离,使得MH闭合成功率非常高(接近90%)。目的比较玻璃体切除(PPV)和内限制膜(ILM)剥脱术后黄斑裂孔闭合与未闭合患者的特征。方法:采用回顾性研究方法,收集2018年7月1日至12月31日行PPV和ILM剥离的患者病历资料。结果:25例患者27眼行MH手术。术后闭合MH 20眼(74%),未闭合MH 7眼(26%)。封闭MH组术前HFF值为1.34±0.90,MHI值为1.09±0.81,未封闭MH组术前HFF值为0.53±0.12,MHI值为0.75±0.10。MHI≥0,5和HFF值≥0,9为预后良好因素。结论:尽管OCT测量具有良好的预后因素和解剖成功,但中央凹微结构对MH术后视力恢复也很重要。
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引用次数: 1
The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy 胞胆碱对非增殖性糖尿病视网膜病变患者视网膜电图异常的影响
Pub Date : 2019-02-27 DOI: 10.35479/ijretina.2019.vol002.iss001.53
Anna Nur Utami, Elvioza Elvioza, M. Sidik
Introduction : to determine the effect of citicoline 1000 mg oral supplementation given for 4 weeks on electroretinography abnormalities in patients with NPDR (non-proliferative diabetic retinopathy). Methods : prospective, double blind, randomized clinical trial. Thirty-eight patients who matched the inclusion and exclusion criteria were randomized into two groups: the placebo (P-NPDR) and citicoline (C-NPDR).  In the end, there were 18 eyes in citicoline group and 16 eyes in placebo group. The primary outcome was P50 and N95 amplitude in PERG within group and intergroup which were taken at the baseline and 4 weeks after treatment. Results : at the end of treatment, the N95 amplitude in C-NPDR showed improvement, 4.85 (1.9-10.3) µV, before treatment to 5.7 (1.9-17.1) µV, after treatment with P = 0.04. Median P50 amplitude improved in both groups, with C-NPDR: 3.1 µV to 3.8 µV (p = 0.89), and P-NPDR: 3.5 µV, to 4.5 µV (p = 0.10). Delta ∆N95 amplitude is higher in C-NPDR, while delta ∆P50 amplitude is higher in P-NPDR, with P values 0.35 and 0.45. Conclusion : Oral citicoline may induce a significant improvement in mean N95 amplitude before and after the treatment. P-NPDR showed positive trend in P50 amplitude while in C-NPDR showed positive trend in N95 amplitude, but these values were not statistically significant (P = 0.45; P= 0.35).
前言:探讨胞胆碱1000mg口服4周对非增殖性糖尿病视网膜病变(NPDR)患者视网膜电异常的影响。方法:前瞻性、双盲、随机临床试验。38例符合纳入和排除标准的患者随机分为两组:安慰剂组(P-NPDR)和胞胆碱组(C-NPDR)。胞胆碱组18只眼,安慰剂组16只眼。主要观察指标为组内、组间PERG P50、N95振幅,分别于治疗前和治疗后4周测定。结果:治疗结束时,C-NPDR的N95振幅有所改善,治疗前为4.85(1.9 ~ 10.3)µV,治疗前为5.7(1.9 ~ 17.1)µV,治疗后P = 0.04。两组的中位P50振幅均有所改善,C-NPDR: 3.1µV至3.8µV (p = 0.89), p - npdr: 3.5µV至4.5µV (p = 0.10)。δ∆N95振幅在C-NPDR中较高,δ∆P50振幅在P- npdr中较高,P值分别为0.35和0.45。结论:口服胞胆碱可显著改善治疗前后N95平均振幅。P- npdr在P50振幅上呈阳性趋势,C-NPDR在N95振幅上呈阳性趋势,但差异无统计学意义(P = 0.45;P = 0.35)。
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引用次数: 0
THE EFFECT OF MANGOSTEEN (GARCINIA MANGOSTANA) PERICARP EXTRACT ON RETINOBLASTOMA CELL CULTURE PROLIFERATION 山竹果皮提取物对视网膜母细胞瘤细胞增殖的影响
Pub Date : 2019-02-27 DOI: 10.35479/ijretina.2019.vol002.iss001.59
Fariz Nufiarwan, Lely Retno Wulandari
Introduction: To determine the effect of mangosteen (Garcinia mangostana) pericarp extracts  on retinoblastoma cell culture proliferation. Methods: This study is a true experimental in vitro design with pre and post-test control group design. Research using retinoblastoma cell culture exposed by mangosteen pericarp extract (Garcinia mangostana) at a dose of 10 µg/ml, 20 µg/ml, and 40 µg/ml. Result: This study used retinoblastoma cell line cultures were obtained from the American Type Culture Collection (ATCC) 10801 University Boulevard Manassas, VA 20110 USA. The samples were divided into 4 groups: control group and 3 groups treated with doses of 10 µg/ml, 20 µg/ml and 40 µg/ml and then incubated for 48 hours, and then examined using MTT Cell Proliferation Assay. Group 1 (10 µg/ml) obtained a decrease of 151.8%, group 2 (20 µg/ml) of 134.6% and group 3 (40 µg/ml) of 134.36%. Conclusion: Mangosteen pericarp extract (Garcinia mangostana) can reduce retinoblastoma  culture cell proliferation.
前言:测定山竹果皮提取物对视网膜母细胞瘤细胞培养增殖的影响。方法:采用真正的体外实验设计,采用试验前后对照组设计。山竹果皮提取物(Garcinia mangostana)剂量分别为10µg/ml、20µg/ml和40µg/ml,对视网膜母细胞瘤细胞培养的研究。结果:本研究使用的视网膜母细胞瘤细胞系培养物来自美国类型培养库(ATCC) 10801 University Boulevard Manassas, VA 20110 USA。将样品分为4组:对照组和3组,分别以10µg/ml、20µg/ml和40µg/ml剂量处理,孵育48 h,然后采用MTT细胞增殖试验检测。1组(10µg/ml)减少151.8%,2组(20µg/ml)减少134.6%,3组(40µg/ml)减少134.36%。结论:山竹果皮提取物具有抑制视网膜母细胞瘤培养细胞增殖的作用。
{"title":"THE EFFECT OF MANGOSTEEN (GARCINIA MANGOSTANA) PERICARP EXTRACT ON RETINOBLASTOMA CELL CULTURE PROLIFERATION","authors":"Fariz Nufiarwan, Lely Retno Wulandari","doi":"10.35479/ijretina.2019.vol002.iss001.59","DOIUrl":"https://doi.org/10.35479/ijretina.2019.vol002.iss001.59","url":null,"abstract":"Introduction: To determine the effect of mangosteen (Garcinia mangostana) pericarp extracts  on retinoblastoma cell culture proliferation. \u0000Methods: This study is a true experimental in vitro design with pre and post-test control group design. Research using retinoblastoma cell culture exposed by mangosteen pericarp extract (Garcinia mangostana) at a dose of 10 µg/ml, 20 µg/ml, and 40 µg/ml. \u0000Result: This study used retinoblastoma cell line cultures were obtained from the American Type Culture Collection (ATCC) 10801 University Boulevard Manassas, VA 20110 USA. The samples were divided into 4 groups: control group and 3 groups treated with doses of 10 µg/ml, 20 µg/ml and 40 µg/ml and then incubated for 48 hours, and then examined using MTT Cell Proliferation Assay. Group 1 (10 µg/ml) obtained a decrease of 151.8%, group 2 (20 µg/ml) of 134.6% and group 3 (40 µg/ml) of 134.36%. \u0000Conclusion: Mangosteen pericarp extract (Garcinia mangostana) can reduce retinoblastoma  culture cell proliferation.","PeriodicalId":33128,"journal":{"name":"IJRETINA International Journal of Retina","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82693306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profile of Patients with Floaters in Saiful Anwar Hospital Malang 玛琅安华医院飞蚊症患者分析
Pub Date : 2018-08-24 DOI: 10.35479/IJRETINA.2018.VOL001.ISS002.31
Fenti Kusumawardhani Hidayah, N. Dewi, Safaruddin Refa
Introduction: To report the profile of patients with floaters as a subjective complain in Saiful Anwar Hospital from July 2012 until June 2013. Methods: an observasional descriptive study was conducted, collecting data on gender, age, subjective complain (floaters, flashes and subjective vision reduction), best corrected visual acuity and diagnose from patient’s medical record. Result: 169 patients (215 eyes) were included in this study. Female patients contributed a higher percentage than male with mean of age was 49 years old. The subjective complain was floaters (67%), floater with blurred vision (22%), floater with flashes (6%) and patients with floaters, flashes, and blurred vision was 5%. Myopia was the most common refraction problem. Diagnose recorded from this study were posterior vitreous detachment (PVD) (34%), no abnormalities (13%), PDR (10%), RRD (9%), peripheral retinal degeneration (14%) retinal break (6%), corpus vitreous degeneration (3%), vitreous haemorhage (3%), posterior uveitis (2%) and others (6%). Conclusion: The most common cause of floaters is PVD. Even it is usually a save condition but there are some condition with floater as a subjective complain which is threatening vision, so accurate eye examination from anterior to posterior segment were needed.
前言:报告2012年7月至2013年6月Saiful Anwar医院以飞蚊症为主诉的患者概况。方法:采用观察性描述性研究,收集患者的性别、年龄、主观主诉(飞蚊、闪光、主观视力下降)、最佳矫正视力和诊断资料。结果:169例患者(215只眼)纳入本研究。女性患者的比例高于男性,平均年龄为49岁。主观主诉为飞蚊症(67%)、飞蚊症伴视力模糊(22%)、飞蚊症伴闪光(6%)、飞蚊症伴闪光伴视力模糊(5%)。近视是最常见的屈光问题。本研究记录的诊断为玻璃体后脱离(PVD)(34%)、无异常(13%)、PDR(10%)、RRD(9%)、周围性视网膜变性(14%)、视网膜破裂(6%)、玻璃体变性(3%)、玻璃体出血(3%)、后葡萄膜炎(2%)和其他(6%)。结论:飞蚊最常见的原因是PVD。虽然这通常是一种不常见的情况,但也有一些情况以漂浮物为主诉,威胁视力,因此需要从前到后段进行准确的眼科检查。
{"title":"Profile of Patients with Floaters in Saiful Anwar Hospital Malang","authors":"Fenti Kusumawardhani Hidayah, N. Dewi, Safaruddin Refa","doi":"10.35479/IJRETINA.2018.VOL001.ISS002.31","DOIUrl":"https://doi.org/10.35479/IJRETINA.2018.VOL001.ISS002.31","url":null,"abstract":"Introduction: To report the profile of patients with floaters as a subjective complain in Saiful Anwar Hospital from July 2012 until June 2013. \u0000Methods: an observasional descriptive study was conducted, collecting data on gender, age, subjective complain (floaters, flashes and subjective vision reduction), best corrected visual acuity and diagnose from patient’s medical record. \u0000Result: 169 patients (215 eyes) were included in this study. Female patients contributed a higher percentage than male with mean of age was 49 years old. The subjective complain was floaters (67%), floater with blurred vision (22%), floater with flashes (6%) and patients with floaters, flashes, and blurred vision was 5%. Myopia was the most common refraction problem. Diagnose recorded from this study were posterior vitreous detachment (PVD) (34%), no abnormalities (13%), PDR (10%), RRD (9%), peripheral retinal degeneration (14%) retinal break (6%), corpus vitreous degeneration (3%), vitreous haemorhage (3%), posterior uveitis (2%) and others (6%). \u0000Conclusion: The most common cause of floaters is PVD. Even it is usually a save condition but there are some condition with floater as a subjective complain which is threatening vision, so accurate eye examination from anterior to posterior segment were needed.","PeriodicalId":33128,"journal":{"name":"IJRETINA International Journal of Retina","volume":"49 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90649879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Outcome of Vitrectomy Surgery in Dropped Nucleus at Jakarta Eye Center 雅加达眼科中心玻璃体切除掉核的疗效
Pub Date : 2018-08-24 DOI: 10.35479/ijretina.2018.vol001.iss002.28
Referano Agustiawan, Elvioza Elvioza, Soedarman Sjamsoe, Waldensius Girsang
Introduction: To report management and outcome of dropped nucleus in Jakarta Eye Center Methods: Retrospective review of the records of 19 consecutive patients who underwent pars plana vitrectomy for retain lens fragments at Jakarta Eye Center from January 2010 to September 2012.  Result: The mean age of the patient was 57 years (range 48-79). There were 10 males (53%) and 9 females (47%). 10 patients (53%) had vitrectomy within 1 day of phacoemulsification, 6(32%) within 1 week and 3(15%) after more than 1 week. Eight patients (42%) achieved a final visual acuity of 0.5 or better, only 3 patients (15%) had final visual acuity 1-meter finger counting or worse. 74% patient achieved final acuity better than pre-op (14 patients). Early vitrectomy group has 3 patients (30%) with complication, intermediate vitrectomy group has 33% complication and late vitrectomy has 33 % complication. Posterior chamber IOL were implanted in 12 patients (63%), 2 patients had scleral fixation IOL, anterior chamber IOL in 2 patients, and only 3 patients (16%) were left aphakic. Conclusion: Surgical management in cases of nucleus drop in JEC showed good result with very limited complications.  In most cases, vitrectomy was performed immediately after cataract surgery. Early vitrectomy has no significant differences in complications and visual outcome than 1 week vitrectomy and late vitrectomy after cataract surgery.  
方法:回顾性分析2010年1月至2012年9月在雅加达眼科中心连续行玻璃体切割术治疗晶状体残留碎片的19例患者的记录。结果:患者平均年龄57岁(48 ~ 79岁)。男性10例(53%),女性9例(47%)。10例(53%)在超声乳化术后1天内行玻璃体切除术,6例(32%)在1周内行,3例(15%)在1周以上行玻璃体切除术。8例(42%)患者最终视力达到0.5及以上,仅有3例(15%)患者最终视力低于1米指数。74%患者的最终视力优于术前(14例)。早期玻璃体切除术组并发症3例(30%),中期玻璃体切除术组并发症33%,晚期玻璃体切除术组并发症33%。后房型人工晶状体12例(63%),巩膜固定型人工晶状体2例,前房型人工晶状体2例,无晶状体3例(16%)。结论:手术治疗JEC核下降效果良好,并发症极少。在大多数情况下,白内障手术后立即进行玻璃体切除术。白内障术后早期玻璃体切除术与术后1周玻璃体切除术和晚期玻璃体切除术相比,并发症和视力无显著差异。
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引用次数: 0
Polypoidal Choroidal Vasculopathy 息肉样脉络膜血管病
Pub Date : 2018-08-24 DOI: 10.35479/IJRETINA.2018.VOL001.ISS002.46
Mirza Metita, Yorihisa Kitagawa, H. Shimada, H. Nakashizuka
Introduction: to report a case of PCV that has been successfully treated with intravitreal injection of  t-PA,  ranibizumab, and pneumatic displacement. Method: A 65 years old man presented with blurred vision of his right eye. No systemic abnormalities were found. Initial visual acuity RE was  6/18. Funduscopy examination showed submacular hemorrhage in posterior pole. OCTA,  FA and ICG confirmed the diagnosis of PCV. We performed anterior chamber paracentesis and intravitreal injection of 0,05 ml t-PA,  0,05 ml ranibizumab, and 0,3 ml 100% C3F8 at a  time in retrobulbar anesthesia. The patient was instructed to maintain face down positioning for 2 days. Results: We evaluated the visual acuity, central retinal thickness (CRT), and central pigment epithelial detachment  (PED) thickness for 2 years. The visual acuity was increasing  gradually from 6/18 to 6/6 in the first year. The  hemorrhage was displaced completely, the CRT and central PED thickness  were decreased. In the second year the patient  had recurrence of PCV with serous retinal detachment and treated  with intravitreal aflibercept. Conclusion: Combined treatment of intravitreal t-PA, ranibizumab, and C3F8 can be used as a beneficial  therapy for PCV.
简介:报告一例PCV已成功治疗的玻璃体内注射t-PA,雷尼单抗和气动置换。方法:65岁男性,右眼视力模糊。未发现全身性异常。初始视力RE为6/18。眼底镜检查显示后极黄斑下出血。OCTA、FA和ICG证实PCV的诊断。我们在球后麻醉下进行前房穿刺和玻璃体内注射0.05 ml t-PA、0.05 ml雷尼单抗和0.3 ml 100% C3F8。嘱患者保持面朝下体位2天。结果:我们对视力、视网膜中央厚度(CRT)和中央色素上皮脱离(PED)厚度进行了为期2年的评估。第一年视力由6/18逐渐提高到6/6。出血完全移位,CRT和中央PED厚度减少。在第二年,患者复发的PCV,浆液性视网膜脱离和治疗玻璃体内阿伯西普。结论:玻璃体内注射t-PA、雷尼单抗、C3F8联合治疗可作为治疗PCV的有效方法。
{"title":"Polypoidal Choroidal Vasculopathy","authors":"Mirza Metita, Yorihisa Kitagawa, H. Shimada, H. Nakashizuka","doi":"10.35479/IJRETINA.2018.VOL001.ISS002.46","DOIUrl":"https://doi.org/10.35479/IJRETINA.2018.VOL001.ISS002.46","url":null,"abstract":"Introduction: to report a case of PCV that has been successfully treated with intravitreal injection of  t-PA,  ranibizumab, and pneumatic displacement. \u0000Method: A 65 years old man presented with blurred vision of his right eye. No systemic abnormalities were found. Initial visual acuity RE was  6/18. Funduscopy examination showed submacular hemorrhage in posterior pole. OCTA,  FA and ICG confirmed the diagnosis of PCV. We performed anterior chamber paracentesis and intravitreal injection of 0,05 ml t-PA,  0,05 ml ranibizumab, and 0,3 ml 100% C3F8 at a  time in retrobulbar anesthesia. The patient was instructed to maintain face down positioning for 2 days. \u0000Results: We evaluated the visual acuity, central retinal thickness (CRT), and central pigment epithelial detachment  (PED) thickness for 2 years. The visual acuity was increasing  gradually from 6/18 to 6/6 in the first year. The  hemorrhage was displaced completely, the CRT and central PED thickness  were decreased. In the second year the patient  had recurrence of PCV with serous retinal detachment and treated  with intravitreal aflibercept. \u0000Conclusion: Combined treatment of intravitreal t-PA, ranibizumab, and C3F8 can be used as a beneficial  therapy for PCV.","PeriodicalId":33128,"journal":{"name":"IJRETINA International Journal of Retina","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75929735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-VEGF Therapy In Central Retinal Vein Occlusions 抗vegf治疗视网膜中央静脉阻塞
Pub Date : 2018-08-23 DOI: 10.35479/IJRETINA.2018.VOL001.ISS002.42
Meidina Rahmah, Ramzi Amin, Ak Ansyori
Introduction: Central retinal vein occlusion (CRVO) is the second most common retinal vascular disease after diabetic retinopathy and is estimated to affect more than 16 million adults worldwide. Treating the underlying cause of occlusion of the central retinal vein, reducing the risk factors, and early and proper management are the keys toward a better prognosis in patients with CRVO. Repeated frequent treatment of CRVO with macular edema with intravitreal anti-vascular endothelial growth factor (anti-VEGF) is an effective treatment to improve visual outcome. In this case report we assess the 3-month efficacy of anti-VEGF therapy in CRVO. Method: In this case, a 52-year-old man presented with an acute loss of vision over the last week in his left eye. His baseline visual acuity was 1/60 and his central retinal thickness (CRT) on Optical Coherence Tomography (OCT) was 523 μm. Fundus examination revealed a hemorrhage in all four quadrants, hard exudates, swelling of the optic nerve, and macular edema. Laboratory test confirms hyperlipidemia and we consult this patient to Internal Medicine Department. This patient got 3 monthly injections of 1,25 mg Bevacizumab. Results: By 3 months, the OCT appeared fairly normal and the visual acuity improved to 6/60 Conclusion: Anti-VEGF therapy is effective for treating macular edema secondary to CRVO
视网膜中央静脉阻塞(CRVO)是仅次于糖尿病视网膜病变的第二大常见视网膜血管疾病,据估计全世界有超过1600万成年人受到影响。治疗视网膜中央静脉阻塞的根本原因,减少危险因素,早期妥善处理是CRVO患者获得更好预后的关键。玻璃体内抗血管内皮生长因子(anti-VEGF)反复频繁治疗CRVO伴黄斑水肿是改善视力的有效治疗方法。在本病例报告中,我们评估了抗vegf治疗在CRVO中3个月的疗效。方法:在这个病例中,一名52岁的男性在过去的一周里出现了左眼的急性视力丧失。基线视力为1/60,光学相干断层扫描(OCT)视网膜中央厚度为523 μm。眼底检查发现四个象限出血,硬渗出物,视神经肿胀,黄斑水肿。实验室检查证实为高脂血症,我们将患者转至内科。该患者每月注射125 mg贝伐单抗3次。结果:3个月时OCT基本正常,视力达到6/60。结论:抗vegf治疗CRVO继发性黄斑水肿有效
{"title":"Anti-VEGF Therapy In Central Retinal Vein Occlusions","authors":"Meidina Rahmah, Ramzi Amin, Ak Ansyori","doi":"10.35479/IJRETINA.2018.VOL001.ISS002.42","DOIUrl":"https://doi.org/10.35479/IJRETINA.2018.VOL001.ISS002.42","url":null,"abstract":"Introduction: Central retinal vein occlusion (CRVO) is the second most common retinal vascular disease after diabetic retinopathy and is estimated to affect more than 16 million adults worldwide. Treating the underlying cause of occlusion of the central retinal vein, reducing the risk factors, and early and proper management are the keys toward a better prognosis in patients with CRVO. Repeated frequent treatment of CRVO with macular edema with intravitreal anti-vascular endothelial growth factor (anti-VEGF) is an effective treatment to improve visual outcome. In this case report we assess the 3-month efficacy of anti-VEGF therapy in CRVO. \u0000Method: In this case, a 52-year-old man presented with an acute loss of vision over the last week in his left eye. His baseline visual acuity was 1/60 and his central retinal thickness (CRT) on Optical Coherence Tomography (OCT) was 523 μm. Fundus examination revealed a hemorrhage in all four quadrants, hard exudates, swelling of the optic nerve, and macular edema. Laboratory test confirms hyperlipidemia and we consult this patient to Internal Medicine Department. This patient got 3 monthly injections of 1,25 mg Bevacizumab. \u0000Results: By 3 months, the OCT appeared fairly normal and the visual acuity improved to 6/60 \u0000Conclusion: Anti-VEGF therapy is effective for treating macular edema secondary to CRVO","PeriodicalId":33128,"journal":{"name":"IJRETINA International Journal of Retina","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80770205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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IJRETINA International Journal of Retina
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