In the present study, the effects of magnetic field strength, nanoparticle magnetization, natural convection, tumour blood retention capacity and tumour rigidity on magnetic hyperthermia cancer therapy in malignant liver tissues in a solenoidal magnetic field are considered. The liver tissue region is modelled as a thermoporoelastic healthy liver tissue surrounding a cancerous region. This is achieved by using the Navier–Cauchy equations to describe the deformation of the tissues, Darcy’s law to describe the fluid flow, continuity equation to describe the conservation of mass and the energy equation to describe the temperature distribution within our system. A finite element/finite difference scheme for this system of equations is constructed and implemented via MATLAB R2024a, and the results are simulated graphically. It was found that an increase in magnetic field strength or nanoparticle magnetization significantly increases the tissue temperature and the chance of tissue death within our system. Moreover, it also significantly increases the deformation of the tissues and interstitial blood pressure. Although the blood retention and rigidity of the tumour significantly affect the local blood pressure and the deformation, they have a negligible effect of the temperature and tissue cell death. The major implication of these findings is that the effectiveness of this therapy is not significantly impacted by tumour blood retention capacity or tumour rigidity, but is greatly affected by the magnetic field strength and nanoparticle magnetization.
扫码关注我们
求助内容:
应助结果提醒方式:
