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A Study on the Dielectric Behaviour of Plant Cell Suspensions using Wideband Electrical Impedance Spectroscopy (WB-EIS) 利用宽带电阻抗谱研究植物细胞悬浮液的介电行为
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278940
Kian Kadan-Jamal, Aakash Jog, M. Sophocleous, Dayananda Desagani, Orian Teig-Sussholz, J. Georgiou, A. Avni, Y. Shacham-Diamand
This paper presents the dielectric behaviour of suspensions of tomato cells (MSK8) and tobacco cells (BY2) in Murashige and Skoog, and Phosphate Buffer solutions. The behaviour of various concentrations of such suspensions is studied over a wide range of frequencies (1 kHz to 20 GHz). A distinct trend is observed in the relation between cell concentration and the capacitance of the first dispersion (i.e. at low frequencies), whilst the capacitance of the second dispersion (at medium frequencies) shows a clear relationship with the medium used. As the concentration of the cells increases, the capacitance observed increases for both cell types in both media. Furthermore, the capacitance observed for the MSK8 cells is higher than that for the BY2 cells in both media; furthermore, the normalized impedance magnitude of the MSK8 cell suspensions at low frequencies is higher than that of the equivalent normalized impedance magnitude for BY2 cells. Finally, the capacitance corresponding to the second dispersion is higher in Phosphate Buffer solution compared to that in Murashige and Skoog solution.
本文研究了番茄细胞悬浮液(MSK8)和烟草细胞悬浮液(BY2)在Murashige和Skoog以及磷酸盐缓冲液中的介电行为。在广泛的频率范围内(1khz至20ghz)研究了不同浓度的这种悬浮液的行为。在电池浓度和第一次色散(即低频)的电容之间的关系中观察到明显的趋势,而第二次色散(中频)的电容与所使用的介质有明确的关系。随着细胞浓度的增加,在两种介质中观察到的两种细胞类型的电容都增加。此外,在两种培养基中,MSK8细胞的电容均高于BY2细胞;此外,MSK8细胞悬浮液在低频时的归一化阻抗值高于BY2细胞的等效归一化阻抗值。最后,与Murashige和Skoog溶液相比,磷酸盐缓冲溶液中第二次色散对应的电容更高。
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引用次数: 0
Monitoring Fibrin Polymerization Effects on Whole Blood Coagulation Using a Microfluidic Dielectric Sensor 用微流体介质传感器监测纤维蛋白聚合对全血凝固的影响
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278794
S. Pourang, Debnath Maji, U. Sekhon, A. Gupta, M. Suster, P. Mohseni
This paper reports on the use of a microfluidic dielectric sensor, termed ClotChip, for monitoring the fibrin polymerization effects on whole blood coagulation. The ClotChip sensor readout captures the temporal variation in the normalized real part of the blood dielectric permittivity at 1MHz as it undergoes coagulation. A new readout parameter, Smax, is identified in the ClotChip readout curve, which represents the maximum permittivity slope after a permittivity peak is reached. Experiments based on ex vivo treatment of whole blood samples with H-Gly-Pro-Arg-Pro-OH (GPRP) – a fibrin-polymerization inhibitor – demonstrate that Smax decreases with increasing GPRP concentrations corresponding to higher levels of fibrin inhibition. Furthermore, Smax is shown to exhibit a strong positive correlation (Pearson’s r = 0.883, p < 0.001, n = 12) with the α-angle readout parameter of rotational thromboelastometry – a clinical, viscoelastometry-based, comprehensive assay of blood coagulation. This work shows the ClotChip potential as a point-of-care platform for rapid assessment of fibrin-polymerization defects and their impact on the overall hemostatic status.
本文报道了一种称为ClotChip的微流体介质传感器,用于监测纤维蛋白聚合对全血凝固的影响。ClotChip传感器读数捕捉血液介电常数在1MHz的归一化实部的时间变化,因为它经历凝固。在ClotChip读出曲线中确定了一个新的读出参数Smax,它表示达到介电常数峰值后的最大介电常数斜率。用纤维蛋白聚合抑制剂H-Gly-Pro-Arg-Pro-OH (GPRP)对全血样本进行体外处理的实验表明,Smax随着GPRP浓度的增加而降低,对应于更高水平的纤维蛋白抑制。此外,Smax显示出很强的正相关(Pearson’s r = 0.883, p < 0.001, n = 12)与旋转血栓弹性测量的α-角度读数参数-一种基于粘弹性测量的临床综合血液凝固分析。这项工作显示了ClotChip作为快速评估纤维蛋白聚合缺陷及其对整体止血状态影响的即时护理平台的潜力。
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引用次数: 4
CMOS Chip for Solid-State Tactile Force Sensor 用于固态触觉力传感器的CMOS芯片
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278689
Sheng-Kai Yeh, Chao-Chun Ning, C. Yeh, S. Tseng, Y. Juang, W. Fang
This study presents a simple approach to design and implement a solid-state micro tactile force sensor using the standard CMOS process (Fig. 1). By using the inductive sensing mechanism with the magnetic force contact interface and the CMOS on-chip analog circuit, the normal force is detected by the inductance change of the sensing coil and readout by characterizing the frequency variation of the LC tank oscillator. The proposed micro tactile force sensor has two major merits: (1) the fabrication process of the proposed tactile sensor is straightforward, and the fragile suspended structure is not required to detect the tactile load. Therefore, the process issues and the design concerns of the unwanted deformation induced by the residual stress of the CMOS thin films can be avoided. (2) Taking the advantages of the standard CMOS process (TSMC 1P6M CMOS process), the sensing component and the processing circuitry are monolithically integrated for direct signal processing with a better signal-to-noise ratio (SNR). The measurement results verify the feasibility and functionality of the proposed micro tactile sensor. For future perspectives, the proposed device can be exploited to the applications required compact tactile force sensing system. Moreover, more processing circuit components can be incorporated monolithically to provide more versatilities.
本研究提出了一种采用标准CMOS工艺设计和实现固态微触觉力传感器的简单方法(图1)。通过具有磁力接触界面的感应传感机构和CMOS片上模拟电路,通过传感线圈的电感变化来检测法向力,并通过表征LC槽振荡器的频率变化来读出法向力。所提出的微触觉力传感器有两个主要优点:(1)所提出的触觉传感器制作工艺简单,不需要脆弱的悬吊结构来检测触觉载荷。因此,可以避免CMOS薄膜的残余应力引起的不必要的变形的工艺问题和设计问题。(2)利用标准CMOS工艺(台积电1P6M CMOS工艺),将传感元件与处理电路单片集成,直接进行信号处理,信噪比更高。测量结果验证了微触觉传感器的可行性和功能性。从未来的角度来看,该装置可以用于紧凑的触觉力传感系统的应用。此外,更多的处理电路元件可以单片集成,以提供更多的通用性。
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引用次数: 2
Enhanced non-contact ultrasonic testing using an air-coupled optical microphone 使用空气耦合光学麦克风的增强非接触式超声检测
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278623
G. Kaniak, W. Rohringer, M. Brauns, Nils Panzer, F. Lücking, B. Fischer, S. Brand, C. Große
In this paper three case studies of the application of a compact non-contact, non-destructive setup are presented. The herein employed method is based on the air-coupled detection of acoustic waves in the frequency range up to 2 MHz.
本文介绍了紧凑型非接触、非破坏性装置的三个应用实例。本文采用的方法是基于空气耦合检测频率范围达2mhz的声波。
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引用次数: 4
Adaptive TOA Estimation with Imperfect LOS and NLOS Knowledge in UWB Positioning Systems 超宽带定位系统中不完全LOS和NLOS知识的自适应TOA估计
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278589
I. Sobrón, I. Landa, I. Eizmendi, M. Vélez
In recent years, localization based on Ultra-Wide Band (UWB) systems has been widely used due to its good positioning performance. However, the system reliability can severely degrade in non-line-of-sight (NLOS) conditions since time of arrival (TOA) estimation is highly conditioned by the presence or absence of line of sight (LOS). This manuscript evaluates an adaptive TOA estimation scheme based on prior knowledge of LOS/NLOS for TDOA-based UWB positioning. Assuming previous identification of LOS/NLOS channels, two correlation-based approaches have been employed for TOA estimation. The adaptive scheme has been assessed in terms of horizontal position error for several LOS and NLOS scenarios. Additionally, the robustness of the adaptive proposal has been studied when employing noisy LOS/NLOS estimates. Simulation results show that the proposed flexible solution outperforms traditional positioning schemes in different channel conditions despite errors in the LOS/NLOS estimates.
近年来,基于超宽带(UWB)系统的定位由于其良好的定位性能得到了广泛的应用。然而,在非视距(NLOS)条件下,系统可靠性会严重下降,因为到达时间(TOA)的估计高度取决于视距(LOS)的存在与否。本文评估了一种基于LOS/NLOS先验知识的超宽带定位自适应TOA估计方案。假设之前已经识别了LOS/NLOS信道,我们采用了两种基于相关的方法来估计TOA。在几种目视和非目视情况下,对自适应方案的水平位置误差进行了评估。此外,还研究了采用噪声LOS/NLOS估计时自适应方案的鲁棒性。仿真结果表明,尽管LOS/NLOS估计存在误差,但该方法在不同信道条件下仍优于传统定位方案。
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引用次数: 2
A Highly Stable Ca2+ Ion-Selective Flexible Sensor Based on Treated PEDOT:PSS Transducing Layer 基于处理PEDOT:PSS转导层的高稳定性Ca2+离子选择性柔性传感器
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278751
Chani Park, H. Yoon, Md. Abu Zahed, Jaeyeong Park
In this work, a highly conductive treated PEDOT:PSS (poly(3,4-ethylenedioxythiophene) : poly(styrene sulfonate)) layer was utilized for the transduction layer of an ion-selective flexible electrode (ISFE) and well-deposited on the carbon paste and polyethylene terephthalate (PET) substrate. The PEDOT:PSS was also treated by a co-solvent of ethylene glycol (EG) using bath-sonication to enhance electrical and electrochemical characteristics and finally coated with Ca2+ selective membrane cocktail. Electrochemical properties exhibited that EG treated PEDOT:PSS drop-casted ISFE achieves improved charge transport with remarkable electric conductivity enhancement. The fabricated Ca2+-ISFE was demonstrated a near-Nernst response of 31.9 mV/decade between 10-4 and 10-1 M with the rapid response (< 20 seconds). Moreover, the EG-treated PEDOT:PSS based ISFE proved significant potential stability with a negligible potential drift of 0.34 mV/min, compared to pristine PEDOT:PSS based ISFE (0.56 mV/min). Based on these analyses, it can be expected that the EG-treated PEDOT:PSS will pave the way for other bio-chemical compounds monitoring.
在这项工作中,利用高导电性处理的PEDOT:PSS(聚(3,4-乙烯二氧噻吩):聚(苯乙烯磺酸盐))层作为离子选择柔性电极(ISFE)的传导层,并将其良好地沉积在碳糊和聚对苯二甲酸乙二醇酯(PET)衬底上。PEDOT:PSS还通过乙二醇(EG)的共溶剂进行浴声处理,以增强电学和电化学特性,最后涂覆Ca2+选择性膜混合物。电化学性能表明,经EG处理的PEDOT:PSS滴铸ISFE的电荷输运得到改善,电导率显著提高。制备的Ca2+-ISFE在10-4 ~ 10-1 M范围内具有31.9 mV/ 10年的近能态响应,响应速度快(< 20秒)。此外,与原始的PEDOT:PSS ISFE (0.56 mV/min)相比,经eg处理的PEDOT:PSS ISFE具有显著的电位稳定性,其电位漂移可忽略不计,为0.34 mV/min。基于这些分析,可以预期egg处理的PEDOT:PSS将为其他生化化合物的监测铺平道路。
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引用次数: 0
All optical readout scheme for photoluminescence based magnetic field sensors 基于光致发光的磁场传感器的全光学读出方案
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278923
L. Horsthemke, C. Bischoff, P. Glösekötter, B. Burchard, R. Staacke, J. Meijer
An improvement on a concept for all optical mag- netometry using nitrogen vacancies in diamond is presented. The concept is based on the fluorescence attenuation of optically pumped nitrogen vacancies by magnetic fields up to ≈ 50 mT. The attenuation is registered by modulating the pumping power to generate a constant signal at a photodetector. A sensitivity of $2.6mu {text{T}}/sqrt {{text{Hz}}} $ at a sampling frequency of 500 Hz is achieved.
提出了一种利用金刚石中氮空位进行全光磁测量的改进方法。该概念是基于高达≈50 mT的磁场对光泵浦氮空位的荧光衰减。衰减通过调制泵浦功率在光电探测器上产生恒定信号来记录。在500hz的采样频率下,灵敏度达到$2.6mu {text{T}}/sqrt {{text{Hz}}} $。
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引用次数: 0
Preliminary Assessment of Human Biological Responses to Low-level Ozone 人类对低水平臭氧生物反应的初步评估
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278620
Tahmid Latif, Laura Gonzalez, J. Dieffenderfer, Yuwei Liao, M. Hernandez, V. Misra, E. Lobaton, A. Bozkurt
Multi-modal wearable sensors monitoring physiology and environment simultaneously would offer a great promise to manage respiratory health, especially for asthmatic patients. In this study, we present a preliminary investigation of the correlation between ozone exposure, heart rate, heart rate variability, and lung function. As the first step, we tested the effect of low-level ozone exposure in a sample size of four healthy individuals. Test subjects underwent controlled exposure from 0.06 to 0.08 ppm of ozone and filtered air on two separate exposure days. Our results indicate an increment in mean heart rate in three out of four test subjects when exposed to ozone. We have also observed that changes in mean heart rate has a positive correlation with changes in lung function and a negative correlation with changes in neutrophil count. These results provide a baseline understanding of healthy subjects as a control group.
同时监测生理和环境的多模态可穿戴传感器将为管理呼吸健康,特别是哮喘患者提供巨大的希望。在这项研究中,我们提出了臭氧暴露,心率,心率变异性和肺功能之间的相关性的初步调查。作为第一步,我们在四个健康个体的样本中测试了低水平臭氧暴露的影响。测试对象在两个单独的暴露日中受控暴露于0.06至0.08 ppm的臭氧和过滤空气中。我们的结果表明,当暴露于臭氧中时,四分之三的测试对象的平均心率会增加。我们还观察到平均心率的变化与肺功能的变化呈正相关,与中性粒细胞计数的变化呈负相关。这些结果为健康受试者作为对照组提供了一个基本的认识。
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引用次数: 0
A Miniature Non-Invasive Wireless Tail-Cuff-Based Heart Rate Sensor With Motion Artifacts Suppression for Real-Time Monitoring of Laboratory Mice 一种用于实验室小鼠实时监测的微型无创无线尾袖运动伪影抑制心率传感器
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278812
Weijie Luo, D. Young
This paper presents the design, implementation, and characterization results of miniature, non-invasive, tail-cuff-based heart rate (HR) sensors for real-time laboratory mice monitoring. 3D-printed lightweight tail-cuffs incorporating MEMS piezo-resistive pressure sensors are developed to minimize animal stress. A tail-cuff design employing two pressure sensors is proposed to suppress differential motion artifacts. The prototype tail-cuff sensors have demonstrated the capability of detecting blood pressure (BP) pulse waveform from a laboratory mouse tail, from which HR and heart rate variability (HRV) can be obtained. Compared to a tail-cuff design employing one pressure sensor, the two-sensor tail-cuff design exhibits a maximum HR error of 4.9%, which is 16 times lower than that obtained from the one-sensor tail-cuff design. Further, a miniature wireless transmitter module is demonstrated to be suitable for BP pulse waveform telemetry.
本文介绍了用于实验室小鼠实时监测的微型、非侵入性、基于尾袖的心率(HR)传感器的设计、实现和表征结果。采用MEMS压阻压力传感器的3d打印轻型尾袖口开发,以最大限度地减少动物压力。提出了一种采用两个压力传感器的尾袖设计来抑制差分运动伪影。尾袖传感器的原型已经证明能够检测实验室小鼠尾部的血压(BP)脉冲波形,从而可以获得HR和心率变异性(HRV)。与单传感器尾袖设计相比,双传感器尾袖设计的最大HR误差为4.9%,比单传感器尾袖设计的HR误差低16倍。此外,还演示了一种适用于BP脉冲波形遥测的微型无线发射机模块。
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引用次数: 2
Temperature sensing by Laser Reduced Graphene Oxide at different Laser Power Levels 激光还原氧化石墨烯在不同激光功率下的温度传感
Pub Date : 2020-10-25 DOI: 10.1109/SENSORS47125.2020.9278645
F. J. Romero, Inmaculada Ortiz-Gómez, A. Salinas, D. Morales, N. Rodríguez, A. Rivadeneyra
Laser reduced graphene oxide (LrGO) has been considered as temperature sensor and its thermal sensitivity has been studied as a function of the reduction laser power level. To do so, LrGO squares of 1 cm2 on a flexible substrate have been fabricated. We found that for the lower tested power (50 mW), both the nominal resistance (about 500 Ω) and temperature sensitivity (around -0.41 Ω/°C) are about 1.5 times higher than the values obtained with an increase in power of 10 mW. The sensor also presented a very linear response (higher than 0.99) and low variation with relative humidity (5 Ω in the RH range from 20% to 90%).
将激光还原氧化石墨烯(LrGO)作为温度传感器,研究了其热敏度随激光还原功率的变化规律。为此,在柔性衬底上制作了1平方厘米的lgo正方形。我们发现,对于较低的测试功率(50 mW),标称电阻(约500 Ω)和温度灵敏度(约-0.41 Ω/°C)都比功率增加10 mW时获得的值高约1.5倍。该传感器还呈现出非常线性的响应(高于0.99)和相对湿度的低变化(5 Ω在RH范围从20%到90%)。
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引用次数: 1
期刊
2020 IEEE Sensors
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