Humoral hypercalcemia of malignancy (HHM) in neoplastic syndrome has been most commonly reported in squamous cell carcinoma. Gallbladder carcinoma with HHM is uncommon. In this report, we describe a male case of gallbladder carcinoma with marked hypercalcemia and a high level of serum parathyroid hormone-related peptide (PTHrP). An immunohistochemical examination using PTHrP was also positive.
{"title":"Humoral hypercalcemia of malignancy (HHM) をきたしたPTHrP産生胆嚢癌の1例","authors":"佳孝 井本, 直樹 六車, 哲夫 木村, 雅子 梶, 弘志 宮本, 誠介 岡村, 進 伊東, 雅彦 中園, 満良 廣川, 壽昭 佐野","doi":"10.11405/NISSHOSHI.104.401","DOIUrl":"https://doi.org/10.11405/NISSHOSHI.104.401","url":null,"abstract":"Humoral hypercalcemia of malignancy (HHM) in neoplastic syndrome has been most commonly reported in squamous cell carcinoma. Gallbladder carcinoma with HHM is uncommon. In this report, we describe a male case of gallbladder carcinoma with marked hypercalcemia and a high level of serum parathyroid hormone-related peptide (PTHrP). An immunohistochemical examination using PTHrP was also positive.","PeriodicalId":341053,"journal":{"name":"The Japanese journal of gastro-enterology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125726994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thirty patients with intraductal papillary-mucinous tumor (IPMT) of the pancreas underwent multidetector-row CT (MD-CT) in addition to endoscopic retrograde pancreatography (ERP), and, in 27 cases magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasonography (EUS). The usefulness of MD-CT was investigated by comparing various imaging methods of the communication from the main pancreatic duct (MPD) to patulous/bulging papilla in addition to the indices for benign or malignant disease, the degree of dilation of the MPD, localization and size of cystic lesions, and presence or absence of neoplastic lesions, such as thickened walls and septa, intramural nodule, solid mass. With MD-CT, dilation of the MPD and localization and size of cystic lesions were accurately assessed, even in patients with obstruction of the main pancreatic duct in whom ERP was difficult to perform regardless of the presence or absence of massive amount of mucus. MD-CT with reconstructive imaging, such as MPR imaging and CPR imaging, allowed us to assess communication with the MPD and patulous/bulging papilla easier than MRCP. In our study, MD-CT was useful in the evaluation of thickened walls and septa that are predictive factors of malignancy in IPMT.
{"title":"膵IPMTにおけるMD-CTの有用性の検討-ERP, EUS, MRCPとの比較-","authors":"俊二 有川, 政史 内田, 正治 品川, 淳 魚住, 尚文 早渕, 義信 岡部, 偉哉 菅, 克司 柳, 壽文 木下, 嘉紀 内藤","doi":"10.11405/NISSHOSHI.104.373","DOIUrl":"https://doi.org/10.11405/NISSHOSHI.104.373","url":null,"abstract":"Thirty patients with intraductal papillary-mucinous tumor (IPMT) of the pancreas underwent multidetector-row CT (MD-CT) in addition to endoscopic retrograde pancreatography (ERP), and, in 27 cases magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasonography (EUS). The usefulness of MD-CT was investigated by comparing various imaging methods of the communication from the main pancreatic duct (MPD) to patulous/bulging papilla in addition to the indices for benign or malignant disease, the degree of dilation of the MPD, localization and size of cystic lesions, and presence or absence of neoplastic lesions, such as thickened walls and septa, intramural nodule, solid mass. With MD-CT, dilation of the MPD and localization and size of cystic lesions were accurately assessed, even in patients with obstruction of the main pancreatic duct in whom ERP was difficult to perform regardless of the presence or absence of massive amount of mucus. MD-CT with reconstructive imaging, such as MPR imaging and CPR imaging, allowed us to assess communication with the MPD and patulous/bulging papilla easier than MRCP. In our study, MD-CT was useful in the evaluation of thickened walls and septa that are predictive factors of malignancy in IPMT.","PeriodicalId":341053,"journal":{"name":"The Japanese journal of gastro-enterology","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128726582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-12-05DOI: 10.11405/NISSHOSHI.103.1384
M. Miyagawa, H. Kanemasa, T. Nitan, M. Matsumoto, K. Tokita, Y. Kajita, A. Yanagisawa, Yusuke Nakamura, T. Sonoyama, H. Yamagishi, S. Mitsufuji, T. Okanoue
: A 69-year-old man was referred to our hospital for epigastralgia. He was found to have elevation of serum amylase and CA19-9. Ultrasonography, abdominal CT, MRCP, ERCP and EUS showed the cystic lesion and a possibility of an other tumor. There was a stenosis of the main pancreatic duct (MPD) at the pancreas head and dilatation of the MPD from the body to the tail. Intraductal papillary mucinous neoplasm (IPMN) of the branch pancreatic duct was diagnosed, and there was a likelihood of ductal carcinoma of the pancreas. We therefore performed pancreatoduodenectomy. Pathological finding showed invasive carcinoma from an intraductal papillary mucinous neoplasm with invasive ductal carcinoma of the pancreas.
{"title":"膵管内乳頭粘液性腫瘍(IPMN)の微小浸潤癌に通常型膵管癌を合併した1例","authors":"M. Miyagawa, H. Kanemasa, T. Nitan, M. Matsumoto, K. Tokita, Y. Kajita, A. Yanagisawa, Yusuke Nakamura, T. Sonoyama, H. Yamagishi, S. Mitsufuji, T. Okanoue","doi":"10.11405/NISSHOSHI.103.1384","DOIUrl":"https://doi.org/10.11405/NISSHOSHI.103.1384","url":null,"abstract":": A 69-year-old man was referred to our hospital for epigastralgia. He was found to have elevation of serum amylase and CA19-9. Ultrasonography, abdominal CT, MRCP, ERCP and EUS showed the cystic lesion and a possibility of an other tumor. There was a stenosis of the main pancreatic duct (MPD) at the pancreas head and dilatation of the MPD from the body to the tail. Intraductal papillary mucinous neoplasm (IPMN) of the branch pancreatic duct was diagnosed, and there was a likelihood of ductal carcinoma of the pancreas. We therefore performed pancreatoduodenectomy. Pathological finding showed invasive carcinoma from an intraductal papillary mucinous neoplasm with invasive ductal carcinoma of the pancreas.","PeriodicalId":341053,"journal":{"name":"The Japanese journal of gastro-enterology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121937406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-12-01DOI: 10.11405/NISSHOSHI.103.1355
K. Koganei, H. Kimura, A. Sugita, K. Arai, T. Fukushima, H. Shimada
Clinical aspects, treatment and outcome of five patients with ulcerative colitis recto- or anovaginal fistula and were studied retrospectively. All patients had total colitis (relapse and remission type) and more than a 5 year history of ulcerative colitis. They all had anorectal complications, such as periproctal abscess, stenosis of fistula. Four patients had total colectomy with an ileal pouch anal canal anastomosis for intractability or dysplasia. One was treated conservatively. Complete closure of fistula was obtained in two patients;in one patient rectum was resected below the fistula and in one patient defect of the vaginal posterior wall was reconstructed by using a gluteal fold flap following colectomy. Recto- or anovaginal fistula complicating ulcerative colitis is rare but may occur in the patients with severe rectal inflammation and they can be managed by restorative proctocolectomy with an ileal pouch anal or anal canal anastomosis.
{"title":"直腸(肛門)膣瘻を合併した潰瘍性大腸炎の治療経験","authors":"K. Koganei, H. Kimura, A. Sugita, K. Arai, T. Fukushima, H. Shimada","doi":"10.11405/NISSHOSHI.103.1355","DOIUrl":"https://doi.org/10.11405/NISSHOSHI.103.1355","url":null,"abstract":"Clinical aspects, treatment and outcome of five patients with ulcerative colitis recto- or anovaginal fistula and were studied retrospectively. All patients had total colitis (relapse and remission type) and more than a 5 year history of ulcerative colitis. They all had anorectal complications, such as periproctal abscess, stenosis of fistula. Four patients had total colectomy with an ileal pouch anal canal anastomosis for intractability or dysplasia. One was treated conservatively. Complete closure of fistula was obtained in two patients;in one patient rectum was resected below the fistula and in one patient defect of the vaginal posterior wall was reconstructed by using a gluteal fold flap following colectomy. Recto- or anovaginal fistula complicating ulcerative colitis is rare but may occur in the patients with severe rectal inflammation and they can be managed by restorative proctocolectomy with an ileal pouch anal or anal canal anastomosis.","PeriodicalId":341053,"journal":{"name":"The Japanese journal of gastro-enterology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122038013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: We report a case of hemostatic treatment by transcatheter arterial embolization (TAE) of the left gastric artery and a branch of the left bronchial artery for oozing hemorrhage in the lower esophagus, because of incomplete endoscopic hemostasis. A 52-year-old woman with systemic lupus erythematosus was previously admitted three times to our hospital for endoscopic treatment of hemorrhage in the lower esophageal lesions. The procedure of TAE for esophageal hemorrhage seems to be a useful treatment for cases of incomplete endoscopic hemostasis.
{"title":"食道の動脈性出血に対して経カテーテル的動脈塞栓術(TAE)により止血しえた1例","authors":"準一 古山, 大島 孝二郎, 森園 竜太郎, 信吾 本城, 明宏 市川, 岡澤 林太郎, 慎一 宮崎, 敬司 草間, 仁志 水尾, 政英 内沢, 達美 腰山, 彩恵 河上","doi":"10.11405/NISSHOSHI.103.1245","DOIUrl":"https://doi.org/10.11405/NISSHOSHI.103.1245","url":null,"abstract":": We report a case of hemostatic treatment by transcatheter arterial embolization (TAE) of the left gastric artery and a branch of the left bronchial artery for oozing hemorrhage in the lower esophagus, because of incomplete endoscopic hemostasis. A 52-year-old woman with systemic lupus erythematosus was previously admitted three times to our hospital for endoscopic treatment of hemorrhage in the lower esophageal lesions. The procedure of TAE for esophageal hemorrhage seems to be a useful treatment for cases of incomplete endoscopic hemostasis.","PeriodicalId":341053,"journal":{"name":"The Japanese journal of gastro-enterology","volume":"3 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131971404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: A 23-year-old woman had lower abdominal pain, diarrhea and bloody stool was admitted and given a diagnosis of influenza B. Her home doctor had started treatment by neuraminidase inhibitor (oseltamivir) the previous day. Colonoscopic examination revealed an area of hemorrhage and erosion in the left transverse colon. After halting oseltamivir treatment these symptoms disappeared and her colonoscopic findings improved. A drug-induced lymphocyte stimulation test was positive for oseltamivir. This case is the first reported case of acute hemorrhagic colitis induced by oseltamivir.
{"title":"リン酸オセルタミビル(タミフル®)が誘因と考えられた急性出血性腸炎の1例","authors":"諭 米田, 洋三 小林, 剛洋 布居, 幸祐 竹田, 篤史 松森, 稔 安藤, 裕久 辻之上, 公男 西村, 博志 福井","doi":"10.11405/NISSHOSHI.103.1270","DOIUrl":"https://doi.org/10.11405/NISSHOSHI.103.1270","url":null,"abstract":": A 23-year-old woman had lower abdominal pain, diarrhea and bloody stool was admitted and given a diagnosis of influenza B. Her home doctor had started treatment by neuraminidase inhibitor (oseltamivir) the previous day. Colonoscopic examination revealed an area of hemorrhage and erosion in the left transverse colon. After halting oseltamivir treatment these symptoms disappeared and her colonoscopic findings improved. A drug-induced lymphocyte stimulation test was positive for oseltamivir. This case is the first reported case of acute hemorrhagic colitis induced by oseltamivir.","PeriodicalId":341053,"journal":{"name":"The Japanese journal of gastro-enterology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122134060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We encountered a solid pseudopapillary tumor (SPT) without any cyst component in an elderly man. A literature survey of SPT without cystic component suggested that the size and vascularity of a tumor were related to lack of cystic component. The prognosis of this disease was comparatively good, but elderly or middle aged case and cases without capsule seem to have high malignant potential.
{"title":"高年男性に発症した嚢胞成分を認めないsolid-pseudopapillary tumor (SPT) の1例","authors":"英樹 宮田, 健一 桑原, 杉山 真一郎, 知博 飯星, 正浩 芹川, 賢惣 小林, 野間 文次郎, 雅英 岩佐, 民人 佐々木, 義昭 村上, 一彰 茶山","doi":"10.11405/NISSHOSHI.103.1288","DOIUrl":"https://doi.org/10.11405/NISSHOSHI.103.1288","url":null,"abstract":"We encountered a solid pseudopapillary tumor (SPT) without any cyst component in an elderly man. A literature survey of SPT without cystic component suggested that the size and vascularity of a tumor were related to lack of cystic component. The prognosis of this disease was comparatively good, but elderly or middle aged case and cases without capsule seem to have high malignant potential.","PeriodicalId":341053,"journal":{"name":"The Japanese journal of gastro-enterology","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134269550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-08-05DOI: 10.11405/NISSHOSHI.103.955
T. Aoki, S. Kino, Hirotaka Yamazaki, M. Obara, S. Kasai, H. Yamasaki, A. Ito
A 72-year-old woman with multilocular liver cysts was admitted. This lesions seemed to be an alveolar hydatid disease. Two methods of Western blotting were used for serologic diagnosis. One method recognizes antigens of crude extracts of Echinococcus multilocularis (EM). The other method recognizes a purified antigen (Em18) of EM. Her serum only reacted with the former method and never reacted with Em18 antigen. Eighteen months after first admission, she had an operation. The resected specimen was diagnosed with simple cysts. Western blotting using Em18 antigen could greatly facilitate the differential diagnosis of simple liver cyst and alveolar hydatid disease.
{"title":"単純性肝胞の1例：Em18-WBによる鑑別診断の有用性","authors":"T. Aoki, S. Kino, Hirotaka Yamazaki, M. Obara, S. Kasai, H. Yamasaki, A. Ito","doi":"10.11405/NISSHOSHI.103.955","DOIUrl":"https://doi.org/10.11405/NISSHOSHI.103.955","url":null,"abstract":"A 72-year-old woman with multilocular liver cysts was admitted. This lesions seemed to be an alveolar hydatid disease. Two methods of Western blotting were used for serologic diagnosis. One method recognizes antigens of crude extracts of Echinococcus multilocularis (EM). The other method recognizes a purified antigen (Em18) of EM. Her serum only reacted with the former method and never reacted with Em18 antigen. Eighteen months after first admission, she had an operation. The resected specimen was diagnosed with simple cysts. Western blotting using Em18 antigen could greatly facilitate the differential diagnosis of simple liver cyst and alveolar hydatid disease.","PeriodicalId":341053,"journal":{"name":"The Japanese journal of gastro-enterology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123562563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"胃食道逆流症(GERD)の新しい考え方-とくにNERD(非びらん性胃食道逆流症)とBarrettの病態について-","authors":"洋人 三輪","doi":"10.11405/NISSHOSHI.103.901","DOIUrl":"https://doi.org/10.11405/NISSHOSHI.103.901","url":null,"abstract":"GERDは「胃食道逆流により症状や合併症が引きおこされる疾患」と定義される比較的新しい概念である．この中には内視鏡で食道炎がないのに症状がある「非びらん性胃食道逆流症NERD」，内視鏡的にびらんなどの粘膜障害が認められる「逆流性食道炎」，食道の円柱上皮化生をきたした「バレット食道」の三つのタイプの疾患が含まれる．これまでこのGERDの三つの疾患の病態は基本的に同様で，その逆流の程度が異なるだけと考えられていた．すなわちNERDは逆流性食道炎の軽症型であり，バレット食道は逆流性食道炎の重症型であるとの考えである．しかし，最近の研究から三つの疾患は食道内への酸逆流をその主な原因とするものの，その病態は基本的に異なっており互いの移行はむしろ少ないのではないかとの新しい考えが提唱され注目されている．","PeriodicalId":341053,"journal":{"name":"The Japanese journal of gastro-enterology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125520554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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