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carboplatin (CBDCA), etoposide (VP-16) による化学療法と放射線療法の併用が奏効した原発性食道小細胞癌の1例 carboplatin (CBDCA), etoposide (VP-16)联合化疗和放疗奏效的原发性食道小细胞癌1例
Pub Date : 2009-09-01 DOI: 10.11405/NISSHOSHI.106.1334
亮一 会澤, 一樹 高倉, 恭仁 久保, 海 吉澤, 拓也 北原, 宏三 安部, 美佳 松岡, 良夫 相澤, 久雄 田尻
: A 78-year-old man was admitted to hour hospital because of dysphagia, and primary small cell carcinoma of the esophagus was diagnosed. Carboplatin (CBDCA) + etoposide (VP-16) combination chemotherapy and radiation therapy was performed. After this therapy, endoscopic examination and computed tomographic scan showed the disappearance of the primary esophageal tumor. Endoscopic examination with biopsy confirmed the disappearance of malignant cells. Severe adverse reactions were not observed during this therapy. This patient is alive without recurrence for 6 years and 3 months. This case seems to provide suggestions on deciding on the operative indications for small cell carcinoma of esophagus.
例78岁男性因吞咽困难入院,诊断为原发性食道小细胞癌。采用卡铂(CBDCA) +依托泊苷(VP-16)联合化疗和放疗。经此治疗后,内镜检查及电脑断层扫描显示原发食道肿瘤消失。内镜检查和活检证实恶性细胞消失。治疗过程中未见严重不良反应。该患者存活6年零3个月无复发。本病例对食管小细胞癌手术指征的确定提供了建议。
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引用次数: 2
肝性脳症・食後腹痛・胆管障害をきたした肝動静脈瘻の1例 肝性脑病、饭后腹痛、胆管障碍引起的肝功能静脉瘘1例
Pub Date : 2009-07-01 DOI: 10.11405/NISSHOSHI.106.1039
Akira Kawano, H. Shigematsu, T. Maruyama, H. Nomura, S. Shimoda
: A 60-year-old woman with hepatic encephalopathy was admitted to our hospital. Ultrasonography, computed tomography and hepatic arteriography revealed diffuse hepatic arteriovenous fistulae (HAVF). Overt portosystemic shunt could not be identified. Right heart catheterization showed increased cardiac output. However the patient had never shown any signs of heart failure. Other than that, marked hepatopetal arterial flow from some branches of the superior mesenteric artery was detected and mesenteric arterial flow remarkably decreased. Extensive HAVF can lead to significant complications, including high output heart failure, pulmonary hypertension, portal hypertension, hepatic encephalopathy, biliary ischemia, cirrhosis, postprandial abdominal pain, and reduced liver function. Embolization or ligation of the hepatic artery provides temporal improvement of clinical symptoms, but long-term results are unsatisfactory because of the development of collateral circulation and the risk of refractory intrahepatic cholangitis, subsequently leading to liver failure. Liver transplantation offers another therapeutic option and can be a successful curative treatment.
我们收治了一位60岁的肝性脑病妇女。超声、ct及肝动脉造影显示弥漫性肝动静脉瘘(HAVF)。未发现明显的门静脉系统分流。右心导管检查显示心输出量增加。然而,患者从未表现出任何心力衰竭的迹象。此外,肠系膜上动脉部分分支可见明显的肝壁动脉血流,肠系膜动脉血流明显减少。广泛的HAVF可导致严重的并发症,包括高输出量心力衰竭、肺动脉高压、门脉高压、肝性脑病、胆道缺血、肝硬化、餐后腹痛和肝功能下降。肝动脉栓塞或结扎可以暂时改善临床症状,但长期效果不理想,因为侧枝循环的发展和难治性肝内胆管炎的风险,随后导致肝衰竭。肝移植提供了另一种治疗选择,可以成功治愈。
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引用次数: 0
食道癌に対する内視鏡治療(EMR/ESD)や内視鏡外科手術による低侵襲治療の展開 开展内窥镜治疗食道癌(EMR/ESD)和内窥镜外科手术微创治疗
Pub Date : 2009-06-01 DOI: 10.11405/NISSHOSHI.106.764
晴洋 井上, 進英 工藤
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引用次数: 0
18F-fluorodeoxyglucose-positoron emission tomography/computed tomography (FDG-PET/CT) で発見されたS状結腸癌術後胃転移の1例 18f - florodeoxyglucose -positoron emission tomography/computed tomography (FDG-PET/CT)中发现的一例乙状结肠癌术后胃转移
Pub Date : 2009-05-01 DOI: 10.11405/NISSHOSHI.106.653
S. Shirakawa, K. Kaneda, H. Fujiwara, Tohru Nishimura, Hiroyoshi Sendo, T. Wada, T. Kizaki
: We report a rare case of a 73-year-old man with gastric metastasis from colorectal cancer. Tumors of the stomach and the right side abdominal wall were diagnosed by FDG/PET-CT. Upper gastrointestinal endoscopy revealed a submucosal tumor with central depression in the fornix of the stomach. Since sigmoidectomy had been performed for cancer 39 months ago, we suspected metastasis. Proximal gastrectomy and resection of the tumor of the abdominal wall were performed. Histological findings showed moderately differentiated adenocarcinoma in the submucosal tumor. Immunohistochemical studies revealed focal positive staining for CK20 and diffuse for CDX2. These findings were similar to those of his primary sigmoid colon cancer and therefore metastasis was diagnosed.
我们报告一例73岁男性结直肠癌胃转移的罕见病例。经FDG/PET-CT诊断为胃及右侧腹壁肿瘤。上消化道内窥镜检查显示胃穹窿处有一粘膜下肿瘤,呈中央凹陷。由于39个月前曾行乙状结肠切除术,我们怀疑有转移。行胃近端切除术及腹壁肿瘤切除术。组织学表现为黏膜下肿瘤为中分化腺癌。免疫组化研究显示CK20呈局灶性阳性,CDX2呈弥漫性阳性。这些发现与他的原发性乙状结肠癌相似,因此被诊断为转移。
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引用次数: 2
ペグインターフェロン·リバビリン併用療法中に脾摘後劇症型感染症(OPSI)を発症したC型慢性肝炎の1例 一例C型慢性肝炎病例,患者在结肠干扰素-利巴韦林联合治疗期间,出现脾摘后激性感染(OPSI)。
Pub Date : 2009-03-05 DOI: 10.11405/NISSHOSHI.106.411
修祐 岡村, 輝文 酒井, 浩史 吉貝, 博明 住江, 成田 高三郎, 卓 辛島, 泰彦 前山, 浩一 檜垣, 達也 井出, 通夫 佐田
: A 61-year-old woman with a past history of splenectomy was admitted to our hospital because of high fever and loss of consciousness during interferon therapy for the treatment of chronic hepatitis type C. She died of multiple organ failure, and disseminated intravascular coagulation shortly after admission. The results of blood culture and the autopsy revealed sepsis due to streptcoccus pneumonia. The neutropenia and immunosuppression by interferon therapy induced overwhelming postsplenectomy infection (OPSI), a potentially rapidly fatal septicemia. When we perform treatment with immunosuppression such as interferon therapy or anticancer drug therapy to splenectomised patients, it is necessary to carry out pnemococcus vaccination. Splenectomy is performed for patients with thrombocytopenia of chronic hepatitis type C before interferon therapy. To avoid OPSI, partial splenic arterial embolization was discussed.
例61岁女性,既往脾切除术,因干扰素治疗慢性丙型肝炎时出现高热、意识丧失,入院后不久因多器官功能衰竭死亡,并发弥散性血管内凝血。血液培养和尸检结果显示是肺炎链球菌引起的败血症。中性粒细胞减少和干扰素治疗的免疫抑制诱导压倒性脾切除术后感染(OPSI),一种潜在的迅速致命的败血症。当我们对脾切除术患者进行免疫抑制治疗,如干扰素治疗或抗癌药物治疗时,有必要进行肺炎球菌疫苗接种。慢性丙型肝炎伴血小板减少患者在干扰素治疗前行脾切除术。为了避免OPSI,我们讨论了部分脾动脉栓塞。
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引用次数: 4
経頸静脈的肝内門脈大循環短絡術(TIPS)による難治性腹水50例の治療成績 经颈静脉肝内门静脉大循环短路术(TIPS)对50例难治性腹水的治疗成绩
Pub Date : 2009-03-01 DOI: 10.11405/NISSHOSHI.106.356
秀典 金沢, 義之 楢原, 健二 福田, 千紗 近藤, 滉智 張本, 洋子 松下, 秀子 城所, 玲樹 片倉, 正則 厚川, 保彦 滝, 祐 木村, 祐二 長田, 雄久 中塚, 長逸 坂本
: In this prospective cohort study, we evaluated the use of transjugular intrahepatic portosystemic shunt (TIPS) in 50 patients with refractory ascites and a Child-Pugh score of 9.8. The mean duration of follow-up was 592 days. Ascites improved in 96% at 1 year and in 93% at 2 years. The cumulative survival rate was 71%, 52% and 18% at 1, 2 and 5 years. The Child-Pugh score and the performance status score improved significantly after TIPS. Thirty six patients required shunt revision during follow-up, due to shunt stenosis. Hepatic encephalopathy which was able to be controlled medically occurred in 26 patients. Our results suggest that although shunt revision may be needed, TIPS can control refractory ascites in most survival cases and improve QOL. However, the 5-year survival rate is still low in our TIPS-treated patients with refractory ascites.
在这项前瞻性队列研究中,我们评估了50例Child-Pugh评分为9.8分的难治性腹水患者使用经颈静脉肝内门系统分流术(TIPS)。平均随访时间为592天。1年后腹水改善96%,2年后腹水改善93%。1年、2年和5年的累计生存率分别为71%、52%和18%。TIPS治疗后Child-Pugh评分和表现状态评分均有显著提高。由于分流管狭窄,36例患者在随访期间需要进行分流管翻修。肝性脑病经医学控制的有26例。我们的研究结果表明,虽然可能需要分流修正,TIPS可以控制难治性腹水在大多数生存病例和改善生活质量。然而,我们的tips治疗的难治性腹水患者的5年生存率仍然很低。
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引用次数: 1
全胃幽門輪温存膵頭十二指腸切除術(PpPD)4年後に繰り返す膵炎に対して膵管チューブ抜去が奏功した1例 全胃幽门轮保留胰头十二指肠切除术(PpPD)对4年后反复胰腺炎胰导管拔除奏效1例
Pub Date : 2009-02-05 DOI: 10.11405/NISSHOSHI.106.228
弘章 新後閑, 雄生 浮田, 知子 南部, 繁文 大牟田, 琢郎 遠藤, 容 前谷
A 54-year-old man had repeated pancreatitis since three years after pylorus-preserving pancreatoduodenectomy (PpPD) and reconstruction by the modified Child method. Since abdominal pain appeared after meals, a pancreatic duct tube was removed endoscopically, which resulted in an improvement. It has been postulated that a pancreatic duct tube, used at the anastomosis between the pancreas and gastrointestinal tract, is spontaneously dislodged or creates a spatial gap with the wall of the main pancreatic duct enough to let the pancreatic juice outflow. However, endoscopic removal of the tube remained in place was significantly effective. We here discussed this case with reference of previous published reports.
一位54岁的男性患者在采用改良Child法行保留幽门的胰十二指肠切除术(PpPD)和重建术后3年反复出现胰腺炎。由于饭后出现腹痛,内镜下切除胰管,情况有所改善。据推测,用于胰腺和胃肠道吻合的胰管自发移位或与主胰管壁产生空间间隙,足以使胰液流出。然而,内窥镜切除导管仍然有效。我们在此参考先前发表的报告讨论了这个案例。
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引用次数: 0
C型肝炎,脂肪性肝疾患に関する消化器内科医,一般内科医の意識調査 消化器官内科医生和一般内科医生关于C型肝炎和脂肪性肝病的意识调查
Pub Date : 2008-12-05 DOI: 10.11405/NISSHOSHI.105.1737
T. Okanoue, T. Shima, M. Mizuno, M. Matsumoto, A. Umemura
: A questionnaire survey including hepatic function test values was performed to elucidate the medical treatment of hepatic diseases by gastroenterologists and general internists. Serum ALT level was considered to be an index of destruction of hepatic cells in 94 and 80% of gastroenterologists and general internists, respectively. Serum gamma-GTP values were used as an index of bile stasis and destruction of the bile duct cells by 93% and 70% of the gastroenterologists, respectively and in 61% and 49% of the internists, respectively. In addition, for hepatitis C, gastroenterologists considered the mean serum ALT values (standard values for drug therapy introduction) as > or =62IU/L, while general internists considered it as > or =79IU/L. In the case of fatty liver, the mean serum ALT values considered by gastroenterologists and general internists were > or =93IU/L and > or =90IU/L, respectively. These survey results suggest that there is a need for research-based clarification of hepatic function test values regulating therapy and unification of guidelines for standard values in medical treatment.
:通过问卷调查,包括肝功能测试值,以阐明胃肠科医生和普通内科医生对肝病的医学治疗。94%的胃肠病学家和80%的内科医生认为血清ALT水平是肝细胞破坏的指标。血清γ - gtp值分别被93%和70%的胃肠病学家以及61%和49%的内科医生用作胆汁淤积和胆管细胞破坏的指标。此外,对于丙型肝炎,胃肠病学家认为血清ALT平均值(药物治疗引入的标准值)>或=62IU/L,而普通内科医生认为>或=79IU/L。在脂肪肝的情况下,胃肠病学家和普通内科医生考虑的平均血清ALT值分别>或=93IU/L和>或=90IU/L。这些调查结果表明,有必要以研究为基础澄清肝功能检测值,规范治疗,统一医疗标准值指南。
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引用次数: 0
IFN-β併用多剤化学療法(DAC-Tam療法)が奏効した直腸肛門部悪性黒色腫の1例 IFN-β联合多药化疗(DAC-Tam疗法)奏效的直肠肛门部恶性黑色素瘤1例
Pub Date : 2008-11-01 DOI: 10.11405/NISSHOSHI.105.1627
紀子 川野, 充生 田代, 雅史 田口, 康之 木原, 一郎 芳川, 和孝 宿輪, 雅弘 山崎, 久米 恵一郎, 眞 大槻
: A 73-year-old man, who was diagnosed as having advanced anorectal malignant melanoma (Stage IV), was treated with combination chemotherapy using dacarbazine, nimustine, cisplatin, and tamoxifen plus interferon-beta. After the first course of chemotherapy, rectal tumor was decreased in size with less anal pain and liver tumor was disappeared. Twenty-four months after the first treatment, the patient is survived. DAC-Tam IFN-beta therapy may improve the management of patients who have advanced MM of the anorectum.
例73岁男性,诊断为晚期肛门直肠恶性黑色素瘤(IV期),采用达卡巴嗪、尼莫司汀、顺铂、他莫昔芬加干扰素联合化疗。第一疗程化疗后,直肠肿瘤体积减小,肛门疼痛减轻,肝脏肿瘤消失。第一次治疗24个月后,患者存活了下来。DAC-Tam ifn - β治疗可改善晚期肛肠MM患者的管理。
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引用次数: 0
18F-fluorodeoxyglucose-positron emission tomography(FDG-PET)にて特徴的な画像を呈した結核性腹膜炎の1例 1 8f - orodeoxyglucose-positron emission tomography(FDG-PET)中呈现特征性图像的结核性腹膜炎1例
Pub Date : 2008-10-05 DOI: 10.11405/NISSHOSHI.105.1515
Shunsuke Yamamoto, Tsutomu Nishida, S. Tsutsui, Katsumi Yamamoto, Takayuki Yakushijin, Takumi Igura, Yoshihiro Kamada, Akira Wada, K. Watabe, Norio Hayashi
A 40's-year-old woman who had abdominal pain with fever was referred to our hospital for further examinations. Abdominal computed tomography showed no focal lesion, and no causative lesion was found after a gynecological examination, upper gastrointestinal endoscopy and colonoscopy. Tuberculin test and QuantiFERON-TB were positive, and thus tuberculous peritonitis was suspected. The level of adenosine deaminase (ADA) in ascites was high, and (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed that FDG accumulated diffusely along the peritoneum. These findings supported the findings of tuberculous peritonitis. Final diagnosis of tuberculous peritonitis was done from laparoscopic biopsy. Combination of QuantiFERON-TB, ADA and FDG-PET was useful in diagnosing tuberculous peritonitis.
一名40岁女性因腹痛伴发烧被转介至我院作进一步检查。腹部ct未见局灶性病变,经妇科检查、上消化道内窥镜检查、结肠镜检查均未发现病因性病变。结核菌素试验及QuantiFERON-TB阳性,怀疑结核性腹膜炎。腹水中腺苷脱氨酶(ADA)水平高,(18)氟脱氧葡萄糖正电子发射断层扫描(FDG- pet)显示FDG沿腹膜弥漫性积聚。这些发现支持结核性腹膜炎的发现。结核性腹膜炎的最终诊断是腹腔镜活检。QuantiFERON-TB联合ADA和FDG-PET对结核性腹膜炎的诊断有一定的价值。
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引用次数: 1
期刊
The Japanese journal of gastro-enterology
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