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Assessing BDNF correlations with non-invasive indicators of neurological decline in different age groups 评估不同年龄组BDNF与非侵入性神经衰退指标的相关性
Pub Date : 2022-12-01 DOI: 10.29052/2412-3188.v9.i2.2022.106-115
S. Batool, F. Mirza
Background: Health is the prime concern of the modern world, and with the increasing life span, both the physical and mental health of human being decline, eventually affecting the cognitive abilities of a person, which may be due to normal aging processes or neuropathological reasons. A cross-sectional study investigated the relationship between BDNF level, neurological disturbance, and aging. Methodology: Cognitive assessment is done through verbal fluency test (FAS, DSST, and 6CIT) and BDNF level in blood found through HPLC utilizing the ALIZA kit method. Results: Descriptive statistics were applied for continuous variables. Hence, one-way ANOVA was performed to show the relationship between cognitive parameters and aging. Conclusion: Our study reports that verbal fluency disturbs as lifetime increases, although sex, education, obesity, or lifestyle does not affect cognition.
背景:健康是现代社会最关心的问题,随着人类寿命的延长,人类的身心健康状况都在下降,最终影响到一个人的认知能力,这可能是由于正常的衰老过程或神经病理原因。一项横断面研究探讨了BDNF水平、神经障碍和衰老之间的关系。方法:通过语言流畅性测试(FAS, DSST和6CIT)和HPLC检测血液BDNF水平进行认知评估,采用elisa试剂盒方法。结果:连续变量采用描述性统计。因此,我们采用单因素方差分析来显示认知参数与衰老之间的关系。结论:我们的研究表明,尽管性别、教育、肥胖或生活方式不会影响认知,但随着寿命的增长,语言流畅性会受到干扰。
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引用次数: 0
The University Students' Concerns about Terrorism, Resilience, and Coping Strategies 大学生对恐怖主义的担忧、心理弹性与应对策略
Pub Date : 2022-12-01 DOI: 10.29052/2412-3188.v9.i2.2022.95-105
S. Ali
Background: Current research inspects the concerns of students of the university about terrorism and their capacity to bounce back, and the coping strategies they are using to deal with it. A cross-sectional study research design is employed in the current study. Methodology: The sample is comprised of 387 students collected from faculties of Karachi University (1) Faculties of Social Sciences, Islamic Studies, Education, Law, and Administrative Sciences and (2)    Faculties of Science, Engineering, Pharmacy, and Medicine.  A consent form, demographic sheet, Students' concerns about terrorism scale, Brief resilience scale, and COPE inventory were administered to students.   Results: Demonstrated significant positive relationship among Anti-Terrorism, Peace, and Female emancipation. Further linear regression analysis shows that peace scores explain a 21.8% variance and female Emancipation score explains an 18.4% variance in the Anti-terrorism score. Multivariate analysis of variance shows a significant difference between gender in scores of Anti-terrorism, peace, female emancipation, and coping strategies (self-destruction, substance use, and positive reframing).    Conclusion: Participants' resilience was found to be in the normal range. A significant positive relationship was found between Anti-Terrorism, Peace, and Female emancipation.  Those who had anti-terrorist views were in favor of peace and Female emancipation.
背景:目前的研究考察了该大学学生对恐怖主义的担忧及其反弹能力,以及他们应对恐怖主义的应对策略。本研究采用了横断面研究设计。方法:样本由387名学生组成,他们来自卡拉奇大学(1)社会科学、伊斯兰研究、教育、法律和行政科学学院和(2)科学、工程、药学和医学学院。对学生进行了同意书、人口统计表、学生对恐怖主义的担忧量表、简要恢复力量表和COPE清单。结果:表明反恐怖主义、和平与女性解放之间存在显著的积极关系。进一步的线性回归分析表明,和平得分解释了21.8%的方差,女性解放得分解释了反恐得分18.4%的方差。多元方差分析显示,在反恐、和平、女性解放和应对策略(自我毁灭、物质使用和积极重塑)方面,性别之间存在显著差异。结论:参与者的恢复力在正常范围内。反恐、和平与女性解放之间存在着显著的正相关关系。那些持反恐怖主义观点的人赞成和平和妇女解放。
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引用次数: 0
The Be aware and grateful for little things: The Relative Contribution of Mindfulness and Gratitude in Predicting Satisfaction 对小事的感知和感恩:正念和感恩在预测满意度中的相对贡献
Pub Date : 2022-12-01 DOI: 10.29052/2412-3188.v9.i2.2022.85-94
Aisha Rais Ahmed, Saima Masoom
Background: Indeed, both Mindfulness and Gratitude go hand in hand. As one goes into a state of mindfulness and opens their heart to gratitude, one may experience more positive feelings toward life and make choices of all types of events with an open-eyed sense in a nonjudgmental way. That may be leading to being overly focused on life circumstances in a constructive way and enhancing people's life satisfaction. The present study aims to recognize the different influences of gratitude and mindfulness in contributing to life satisfaction; and investigate the levels of mindfulness, gratitude, and life satisfaction among university students. Methodology: In the study, 256 young adults were drafted from 4 educational institutes in Karachi. However, the random sampling method was used to recruit them. The mean age of the sample was 20 years, with the range of 18-25. The research tools included Mindful Attention Awareness Scale1, Gratitude Questionnaire-Six Item Form (GQ-6)2, and Satisfaction with Life Scale3 by using a brief demographic sheet and consent form, through which data was obtained.   Results: Descriptive statistics and regression analysis was used to clarify the pattern of the result, and the findings were highly significant at p< .001. The outcomes demonstrated that the level of mindfulness comes in the low range (49.6%) of the study sample, while the range of gratitude was moderate (52.5%) to high levels (42.3%) correspondingly. Almost half of the participants reported a moderate level (49.3%) of life satisfaction. Further, the results showed that mindfulness and gratitude are the highest contributors to Life Satisfaction. As gratitude pointed out, 42% and mindfulness predicted 23% to expect contentment. Conclusion: The study proposed a theoretical paradigm that mindfulness impacts satisfaction cognitively, while gratitude influences satisfaction emotionally. Thus, the benefits of both constructs are evident and improve people's lives.
背景:的确,正念和感恩是相辅相成的。当一个人进入一种正念的状态,敞开心扉去感恩,他可能会对生活有更积极的感受,并以一种不加评判的方式睁大眼睛去选择所有类型的事件。这可能会导致人们以一种建设性的方式过度关注生活环境,提高人们的生活满意度。本研究旨在认识感恩和正念对生活满意度的不同影响;调查大学生的正念、感恩和生活满意度。方法:在研究中,从卡拉奇的4所教育机构征集了256名年轻人。然而,我们采用随机抽样的方法来招募他们。样本的平均年龄为20岁,年龄范围为18-25岁。研究工具包括正念注意意识量表1、感恩问卷-六题表(GQ-6)2和生活满意度量表3,采用简单的人口统计表和同意表,通过这些工具获得数据。结果:采用描述性统计和回归分析澄清了结果的模式,发现p< .001具有高度显著性。结果表明,研究样本的正念水平处于较低的范围(49.6%),而感恩的范围相应处于中等(52.5%)到较高的水平(42.3%)。几乎一半的参与者报告了中等水平(49.3%)的生活满意度。此外,结果显示,正念和感恩是生活满意度的最高贡献者。正如感恩所指出的,42%的人期望满足,而正念预测23%的人期望满足。结论:本研究提出了正念影响认知满意度,感恩影响情感满意度的理论范式。因此,这两种结构的好处是显而易见的,并改善了人们的生活。
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引用次数: 0
Investigating the impact of eye movement desensitization and reprocessing (EMDR) in reducing birth trauma symptoms 眼动脱敏和再加工(EMDR)对减少出生创伤症状的影响
Pub Date : 2022-12-01 DOI: 10.29052/2412-3188.v9.i2.2022.67-75
Silvia Wetherell
Background: Childbirth-related traumatic experiences are an overlooked area of psychological suffering, often leading to Post-Traumatic Stress Disorder, Perinatal Mood and Anxiety Disorders, and difficulties in bonding between mother and baby. This study aimed to evaluate the effectiveness of Eye Movement Desensitization and Reprocessing as a brief psychological intervention in reducing Birth Trauma symptoms. Methodology: Using a prospective experimental longitudinal design, 12 women residing in Singapore with Birth Trauma symptoms received three 90-minute eye-movement and desensitization (EMDR) sessions over two weeks on average. Participants were assessed through two trauma self-report questionnaires and underwent a brief Autonomic Nervous System (ANS) assessment. Results: Post-treatment assessment showed significant differences in mean trauma scores with a 76% reduction on the Modified Perinatal PTSD Questionnaire (z = -3.061, p = .002) and 70% reduction on the Impact of Event Scale Revised (z = -3.061, p = 0.002). Skin conductance response changes from baseline to stressor reduced by 4% but were not statistically significant (z = -.863, p = 0.39). Conclusion: Brief EMDR has shown promise as an effective treatment for Birth Trauma. Larger controlled randomized studies are required to evaluate the effectiveness of EMDR when compared to a placebo control group.
背景:分娩相关的创伤经历是一个被忽视的心理痛苦领域,通常会导致创伤后应激障碍、围产期情绪和焦虑障碍,以及母婴之间的联系困难。本研究旨在评估眼动脱敏和再处理作为一种简短的心理干预措施在减少出生创伤症状方面的有效性。方法:采用前瞻性实验纵向设计,12名居住在新加坡的有出生创伤症状的女性平均在两周内接受了三次90分钟的眼动和脱敏(EMDR)治疗。参与者通过两份创伤自我报告问卷进行评估,并接受了简短的自主神经系统(ANS)评估。结果:治疗后评估显示,平均创伤评分存在显著差异,改良围产期创伤后应激障碍问卷降低了76%(z=-3.061,p=.002),事件影响量表修订版降低了70%(z=3.061,p=0.002)。从基线到压力源的皮肤电导反应变化降低了4%,但无统计学意义(z=-0.863,p=0.39)。结论:简易EMDR有望成为治疗出生创伤的有效方法。与安慰剂对照组相比,需要进行更大规模的对照随机研究来评估EMDR的有效性。
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引用次数: 0
The 6-AF Evaluation of Neuroprotective Activity against Cd- Induced Oxidative Stress and Degenerative Brain Disease including PD in Mice 6-AF对镉诱导的氧化应激和包括PD在内的退行性脑疾病小鼠神经保护活性的评估
Pub Date : 2022-12-01 DOI: 10.29052/2412-3188.v9.i2.2022.76-84
Waqar Ahmad Khan, S. Shah, S. Khan
Background: The neurotoxicity caused by Cadmium (Cd) has been researched internationally. Since it has a wide range of unfavorable effects on people, it is believed to be one of the primary tissue-inducing target agents. Using adult male albino mice, the therapeutic potential of 6-AF to reduce memory impairment, neurodegeneration, and neuroinflammation caused by Cadmium Chloride (CdCl2) was evaluated in the current study for the first time. Methodology: The male adult mice were distributed into 4 sub-groups; Control, Cd treated (1 mg/kg thrice weeks), Cd (1 mg/kg 3 weeks) + 6-AF (30 mg/kg 3 a week for last 2 weeks) and 6-AF treated (30 mg/kg thrice a week for the last two weeks). After the initial seven-day Cdcl2 dosing cycle, the 6-Aminoflavone was administered interpretively intravenously for the following around 14 days (three per week). After receiving Cdcl2 injections for 30 days, behavior tests were conducted. Western blot analysis was performed after the hippocampus was extracted, and the results were then used to develop the X-rays. Results: Our results demonstrate that 6-AF significantly enhanced behavior as assessed by the Y-maze and Morris Water Maze (MWM) and that this enhancement was followed by an inhibition of phospho C-Jun N Terminal Kinase (p-JNK) and its downstream signaling, including tumor necrosis factor-alpha (TNF-alpha), Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-KB), and Poly (ADP-ribose In addition, 6-AF also reduced the expression of NRF-2 proteins in adult mice exposed to oxidative stress caused by cadmium chloride. Conclusion: 6-AF is an effective neuroprotective drug in disorders causing neurodegeneration.
背景:镉(Cd)引起的神经毒性已在国际上得到广泛研究。由于它对人体有广泛的不良影响,因此被认为是主要的组织诱导靶点之一。本研究首次利用成年雄性白化小鼠,对6-AF减轻氯化镉(CdCl2)引起的记忆障碍、神经退行性变和神经炎症的治疗潜力进行了评价。方法:将雄性成年小鼠分为4个亚组;对照:Cd处理(1 mg/kg 3周)、Cd (1 mg/kg 3周)+ 6-AF (30 mg/kg 3周,最后2周)和6-AF处理(30 mg/kg 3周,最后2周)。在最初的7天Cdcl2给药周期后,6-氨基黄酮在接下来的14天左右(每周3次)进行解释性静脉注射。注射Cdcl2 30天后,进行行为测试。提取海马后进行Western blot分析,结果用于显影x光片。结果:我们的研究结果表明,通过y迷宫和Morris水迷宫(MWM)评估,6-AF显著增强了行为,并且这种增强随后抑制了磷酸C-Jun N末端激酶(p-JNK)及其下游信号传导,包括肿瘤坏死因子- α (tnf - α),活化B细胞的核因子kappa轻链增强子(NF-KB)和聚adp核糖。6-AF还能降低氯化镉引起氧化应激的成年小鼠NRF-2蛋白的表达。结论:6-AF是治疗神经退行性疾病的有效神经保护药物。
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引用次数: 0
Psychophysiology of Wellbeing; A must to introduce in undergraduate programs 幸福心理生理学;在本科课程中必须介绍
Pub Date : 2022-12-01 DOI: 10.29052/2412-3188.v9.i2.2022.64-66
S. Noushad
The psychophysiology of wellbeing is an important field of study that explores the relationship between mental and physical health. This interdisciplinary field integrates knowledge from psychology, neuroscience, biology, and physiology to understand how positive emotions, attitudes, and behaviors can impact physical health outcomes. Introducing the psychophysiology of wellbeing in undergraduate programs can provide students with valuable knowledge and skills to promote their own wellbeing and mental health, increase awareness of the connection between mental and physical health, and potentially open up new prospects of collaborations and wellbeing overall.
幸福的心理生理学是探索身心健康之间关系的一个重要研究领域。这个跨学科领域融合了心理学、神经科学、生物学和生理学的知识,以了解积极的情绪、态度和行为如何影响身体健康结果。在本科生项目中引入幸福感的心理生理学可以为学生提供宝贵的知识和技能,以促进他们自己的幸福感和心理健康,提高人们对身心健康之间联系的认识,并有可能开辟合作和整体幸福感的新前景。
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引用次数: 0
Assessment of Burnout Syndrome and Physical Activity of the University Teachers – A cross-sectional Observational Study 高校教师倦怠综合征和体育活动的评估——一项横断面观察研究
Pub Date : 2022-06-01 DOI: 10.29052/2412-3188.v9.i1.2022.17-27
Qazi Noor Ul Wahab, Z. Din, M. Jahanzeb, Saleem Ullah, M. Abbas
Background: Burnout and physical activity (PA) are two critical determinants of health. The burnout and PA of the university teachers in Pakistan are not well, established. The main objective of the present study is to determine the prevalence of burnout syndrome and the level of physical activity in university teachers. Methodology: The sample of university teachers (n=505) was drawn from 14 public/private universities in Peshawar using a partly convenient, non-probabilistic method based on an exhaustive and up-to-date database of all universities in Peshawar. Data were collected on these parameters: socio-demographics, anthropometrics (body weight, height, and body mass index: BMI), Burnout using Maslach Burnout Inventory (MBI-ES), and PA level. The global Physical Activity Questionnaire developed by WHO (GPAQ-WHO) was used.   Results: The sample consisted predominantly of males (78%) with a mean (SD) age of 37.5 ± 7.9 (Range: 28 – 60). The results demonstrated that 19% of university teachers suffered from burnout syndrome, with most of those with job experience <10 years. The mean PA for all the respondents was 955.1 MET minutes/week, with significant differences in PA levels of male and female teachers from public vs. private universities (p, for all trends < 0.05). The proportion of physically active university teachers was 63.6% (95%CI 56.6 to 68.2), with a higher proportion of university teachers without Burnout Syndrome being physically active than those with Burnout Syndrome (73.5% (95%CI 68.1 to 79.3) vs. 21.6% (95%CI 16.5 to 24.6). Only a small number of university teachers could achieve the recommended levels of PA with differences between genders and university types. Conclusion: Work-related burnout is seen in teachers with poor physical activity, and females are mostly affected. Public sector universities showed a greater burnout rate. The public sector needs to revitalize the staff and train them to manage their workload efficiently.
背景:倦怠和体育活动是健康的两个关键决定因素。巴基斯坦大学教师的倦怠和PA状况并不明显。本研究的主要目的是确定大学教师职业倦怠综合征的患病率和体育活动水平。方法:大学教师样本(n=505)来自白沙瓦的14所公立/私立大学,采用部分方便的非概率方法,基于白沙瓦所有大学的详尽和最新数据库。收集了以下参数的数据:社会人口统计、人体测量(体重、身高和体重指数:BMI)、使用Maslach倦怠量表(MBI-ES)的倦怠和PA水平。采用世界卫生组织编制的全球体力活动问卷(GPAQ-WHO)。结果:样本主要由男性(78%)组成,平均(SD)年龄为37.5±7.9(范围:28-60)。结果表明,19%的大学教师患有倦怠综合征,其中大多数教师的工作经验<10年。所有受访者的平均PA为955.1 MET分钟/周,公立大学和私立大学的男女教师的PA水平存在显著差异(p,所有趋势均<0.05)。体育活动的大学教师比例为63.6%(95%CI 56.6至68.2),没有倦怠综合症的大学教师体育活动的比例高于有倦怠综合症的教师(73.5%(95%CI 68.1至79.3)和21.6%(95%CI 16.5至24.6)。只有少数大学教师能够达到推荐的PA水平,但性别和大学类型之间存在差异。结论:体育活动能力差的教师存在与工作相关的倦怠,女性受影响最大。公立大学的倦怠率更高。公共部门需要振兴工作人员,培训他们有效地管理工作量。
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引用次数: 0
Review of Heart Rate Variability Biofeedback: Intervention to relieve Stress. 心率变异性生物反馈:缓解压力的干预研究综述。
Pub Date : 2022-06-01 DOI: 10.29052/2412-3188.v9.i1.2022.51-55
S. Batool, Basit Ansari
Depression is prevailing and captivating millions of individuals across the globe. There are numerous stressors and triggers that can induce depressive symptoms or anxiety in individuals of all ages. This exponential growth in depressed and distressed members of society may lead to a massive loss of productive individuals. It is a general practice to prescribe drugs to treat such psychological concerns, but acquiring these medications frequently may affect the body's metabolism. Alternative interventions that can replace or minimize the use of drugs are needed. Heart rate variability biofeedback (HRVB) is a practical approach to treating stress and depression. This article intends to represent an overview of HRVB, its effectiveness, and its side effects so that it can be compared to the medications prescribed.
抑郁症在全球范围内盛行并吸引着数百万人。在所有年龄段的个体中,有许多压力源和触发因素可以诱发抑郁症状或焦虑。社会中抑郁和痛苦成员的指数级增长可能导致大量有生产力的人的流失。一般的做法是开药来治疗这种心理问题,但频繁服用这些药物可能会影响身体的新陈代谢。需要替代或尽量减少药物使用的其他干预措施。心率变异性生物反馈(HRVB)是一种治疗压力和抑郁的实用方法。本文旨在概述HRVB,其有效性和副作用,以便与处方药物进行比较。
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引用次数: 0
Don't assume that your equipment is doing what you think it is 不要以为你的设备在做你认为的事情
Pub Date : 2022-06-01 DOI: 10.29052/2412-3188.v9.i1.2022.01-05
R. Sherman
A perennial problem encountered by both novices and experienced people using psychophysiological recording equipment and then using the displays as the basis for biofeedback and neurofeedback is that the equipment is frequently not doing what the users think it is. Hardware and software are frequently glitchy and setting the devices incorrectly makes matters worse. The key question to answer is whether the device reliably produces a display clearly related to the physiological signal produced by the person being recorded. The editorial emphasizes the need to view a raw signal so relationships between the physiology being recorded and the display can be accurately assessed. Seven key questions users of psychophysiological recording and biofeedback/neurofeedback equipment need to answer are delineated. They include: (1) Are the sensors mounted optimally for location and orientation, (2) Are the sensors mounted well enough to pick up a good signal, (3) Is the device’s bandwidth set appropriately, (4) Is there noise in the signal, (5) Does the display accurately reflect changes in the signal, (6) Does the display change when the physiological signal does, and (7) Is the display set so users can accurately assess the signal? Users are encouraged to get the training they need to do a great job when performing recordings.
无论是新手还是有经验的人,在使用心理生理记录设备,然后将显示器用作生物反馈和神经反馈的基础时,都会遇到一个长期存在的问题,那就是设备经常没有按照用户的想法进行操作。硬件和软件经常出现故障,设备设置错误会使情况变得更糟。要回答的关键问题是,该设备是否可靠地产生与被记录者产生的生理信号清楚相关的显示。社论强调需要查看原始信号,以便准确评估被记录的生理学和显示之间的关系。描述了心理生理记录和生物反馈/神经反馈设备用户需要回答的七个关键问题。它们包括:(1)传感器的安装是否适合位置和方向,(2)传感器安装是否足够好,能够接收到良好的信号,(3)设备的带宽设置是否适当,(4)信号中是否存在噪声,(5)显示器是否准确地反映了信号的变化,(6)当生理信号发生变化时,显示器是否发生变化,以及(7)是否设置了显示器,以便用户能够准确地评估信号?鼓励用户在进行录音时接受出色工作所需的培训。
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引用次数: 0
Approaches used for the Quantification of Pain in Physical Therapy Practices-A Systematic Review 物理治疗实践中疼痛量化的方法——系统综述
Pub Date : 2022-06-01 DOI: 10.29052/2412-3188.v9.i1.2022.39-50
Shahrukh Abbasi, Shahzaib Naseer, S. Farooqui
Background: This study aimed to determine the most common pain intensity assessment tool that has been used in different physical therapy management-based studies as a primary outcome measure for the quantification of pain. Methodology: The electronic databases including PubMed, Google Scholar, PEDro, and Cochrane Library were searched to identify relevant studies from January 2015 to September 2021 by using keywords like 'pain,' 'pain intensity,' 'Visual Analogue Scale,' and 'Numeric Pain Rating Scale.' Randomized controlled trials or quasi-experimental studies in which pain management is considered an outcome measure published in the English language were included. In contrast, Non-RCTs were excluded that were based on pain management strategies other than physical therapy or conducted in inpatient department or based on approaches of telerehab. Results: The findings revealed that n=1,292 participants were given different physical therapy interventions in which n=792 (61.3%) were evaluated for their pain on VAS, followed by n=453 (35%) on NPRS and n=169 (13%) on PPT of the total population. Conclusion: VAS was the most frequently used tool to determine the patient's perception of pain, followed by NPRS and McGill Pain Questionnaire.
背景:本研究旨在确定在不同的基于物理治疗管理的研究中使用的最常见的疼痛强度评估工具,作为量化疼痛的主要结果指标。方法:检索PubMed、Google Scholar、PEDro和Cochrane Library等电子数据库,使用“疼痛”、“疼痛强度”、“视觉模拟量表”和“数字疼痛评定量表”等关键词,确定2015年1月至2021年9月的相关研究包括以英语发表的随机对照试验或准实验研究,其中疼痛管理被视为一种结果衡量标准。相反,基于物理治疗以外的疼痛管理策略、在住院部进行或基于远程康复方法的非随机对照试验被排除在外。结果:研究结果显示,1292名参与者接受了不同的物理治疗干预,其中792名(61.3%)在VAS上评估了他们的疼痛,其次是453名(35%)在NPRS上和169名(13%)在PPT上。结论:VAS是确定患者疼痛感知的最常用工具,其次是NPRS和McGill疼痛问卷。
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引用次数: 0
期刊
Annals of Psychophysiology
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